Strain Gene Zyg FClass FTerms similarity score p-value rank description GOBP GOMF GOCC
YCR013C_d YCR013C het 1 0 1 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant Unknown Unknown Unknown
YBR193C MED8 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.185203342456693 2.80620685154464e-27 2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter TBP-class protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription corepressor activity|structural molecule activity core mediator complex
YBL020W RFT1 het FT MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.179316191617503 1.19830983926008e-25 3 Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein glycolipid translocation molecular_function|glycolipid-translocating activity integral to membrane|endoplasmic reticulum membrane
YAR008W SEN34 het FT RNA PROCESSING|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION 0.15898405860172 1.9387089594826e-20 4 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease tRNA-type intron splice site recognition and cleavage tRNA-intron endonuclease activity mitochondrial outer membrane|mitochondrion|tRNA-intron endonuclease complex
YMR270C RRN9 het FT NUCLEUS 0.158673712066121 2.39222423924435e-20 5 Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I transcription of nuclear large rRNA transcript from RNA polymerase I promoter TBP-class protein binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity nucleolus|RNA polymerase I upstream activating factor complex
YKL083W_d YKL083W het 0.144008883497032 5.15075670984746e-17 6 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14 Unknown Unknown Unknown
YOR335C ALA1 het FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.143219095507324 7.63644382988919e-17 7 Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog alanyl-tRNA aminoacylation|mitochondrial alanyl-tRNA aminoacylation alanine-tRNA ligase activity mitochondrion|cytoplasm
YIL147C SLN1 het FT SIGNALING|PROTEIN PHOSPHORYLATION|PLASMA MEMBRANE 0.133137611478645 9.68959978445428e-15 8 Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators negative regulation of protein kinase activity|protein autophosphorylation|peptidyl-histidine phosphorylation|osmosensory signaling pathway via two-component system osmosensor activity|protein histidine kinase activity|histidine phosphotransfer kinase activity plasma membrane|integral to plasma membrane
YBL041W PRE7 het FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.131644856779101 2.08303943150358e-14 9 Beta 6 subunit of the 20S proteasome proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YDL007W RPT2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS 0.126570093189293 1.84997656769364e-13 10 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle positive regulation of protein catabolic process|proteasome regulatory particle assembly|peptide catabolic process|ubiquitin-dependent protein catabolic process ATPase activity proteasome regulatory particle, base subcomplex|nucleus
YDR324C UTP4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.126342839862607 2.04390252459297e-13 11 Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|nucleolus|t-UTP complex|90S preribosome
YHR197W RIX1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.122358289295394 1.14012801664292e-12 12 Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene ribosomal large subunit assembly|ribosomal subunit export from nucleus|rRNA processing molecular_function nucleoplasm|nucleus
YER172C BRR2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS 0.1216672728213 1.5275355581532e-12 13 RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) ATP-dependent RNA helicase activity U4/U6 x U5 tri-snRNP complex|U5 snRNP
YGL142C GPI10 het FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.118674828113399 5.31968146936529e-12 14 Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog GPI anchor biosynthetic process dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity integral to membrane
YMR288W HSH155 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS 0.117633799804339 8.38726463233962e-12 15 U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155 spliceosomal complex assembly|mRNA splicing, via spliceosome mRNA binding U2 snRNP|U2-type prespliceosome
YML046W PRP39 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS 0.11616009793499 1.48230536040974e-11 16 U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats mRNA 5'-splice site recognition pre-mRNA 5'-splice site binding commitment complex|U1 snRNP|U2-type prespliceosome
YDR373W FRQ1 het FT SIGNALING|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE 0.114570419208325 2.80168180076991e-11 17 N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily regulation of signal transduction enzyme activator activity|calcium ion binding Golgi membrane
YER018C SPC25 het FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE 0.114551232740878 2.82314264908975e-11 18 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering microtubule nucleation|chromosome segregation structural constituent of cytoskeleton Ndc80 complex|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region
YOR218C_d YOR218C het 0.113969655509843 3.55571675097652e-11 19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W Unknown Unknown Unknown
YER147C SCC4 het FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.112847697794646 5.53094667923516e-11 20 Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX double-strand break repair|establishment of protein localization to chromatin|rDNA condensation|mitotic chromosome condensation|mitotic sister chromatid cohesion molecular_function nuclear chromatin|SMC loading complex
YBL004W UTP20 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.1105514474855 1.34795319524537e-10 21 Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleoplasm|small-subunit processome|preribosome, small subunit precursor|nucleolus|90S preribosome|cytoplasm
YDR023W SES1 het FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION 0.110465995798058 1.39290377149759e-10 22 Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p seryl-tRNA aminoacylation serine-tRNA ligase activity cytoplasm
YDL060W TSR1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.109507980243237 2.0086290689047e-10 23 Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress rRNA processing|ribosome biogenesis ribonucleoprotein complex binding nucleolus|cytoplasm|90S preribosome
YFL037W TUB2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION|NUCLEUS|CYTOSKELETON 0.10811973244016 3.41571368321093e-10 24 Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation structural constituent of cytoskeleton tubulin complex|kinetochore microtubule|cytoplasmic microtubule|nuclear microtubule|spindle pole body|polar microtubule
YIL150C MCM10 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME 0.106481446009929 6.25507272235904e-10 25 Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|double-strand break repair via break-induced replication|DNA replication initiation|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette double-stranded DNA binding|protein binding|DNA replication origin binding|single-stranded DNA binding replication fork protection complex|replication fork|nucleus
YGL018C JAC1 het FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.105177195143651 1.0107963846802e-09 26 Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix iron-sulfur cluster assembly|aerobic respiration chaperone binding mitochondrion
YGR198W YPP1 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|PLASMA MEMBRANE|CYTOSKELETON 0.102253572457 3.03072132001305e-09 27 Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene receptor-mediated endocytosis|response to pheromone|protein targeting to vacuole molecular_function endosome|cytosol|ribosome|plasma membrane|actin cortical patch|cytoplasm
YKL088W CAB3 het FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM 0.102189359710281 2.96971897003939e-09 28 Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC response to salt stress|coenzyme A biosynthetic process phosphopantothenoylcysteine decarboxylase activity|purine nucleotide binding phosphopantothenoylcysteine decarboxylase complex|cytoplasm
YKL042W SPC42 het FT CELL CYCLE|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON 0.0992489510115866 8.5428681859289e-09 29 Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane microtubule nucleation|spindle pole body duplication associated with nuclear envelope structural constituent of cytoskeleton central plaque of spindle pole body|intermediate layer of spindle pole body
YKL173W SNU114 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEOTIDE METABOLISM|NUCLEUS 0.0986716276660607 1.01622647287953e-08 30 GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2 assembly of spliceosomal tri-snRNP|spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step GTP binding|GTPase activity|U5 snRNA binding U4/U6 x U5 tri-snRNP complex|U5 snRNP
YER126C NSA2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0984959819572986 1.0794261695116e-08 31 Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleus|preribosome, large subunit precursor
YDR498C SEC20 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0954322362747778 3.06962921476041e-08 32 Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p retrograde vesicle-mediated transport, Golgi to ER|vesicle fusion with endoplasmic reticulum SNAP receptor activity SNARE complex|integral to membrane|endoplasmic reticulum|peroxisome
YNL161W CBK1 het FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH 0.0954250126343506 3.06254274519562e-08 33 Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress regulation of fungal-type cell wall organization|establishment or maintenance of cell polarity|protein phosphorylation|establishment or maintenance of actin cytoskeleton polarity|budding cell apical bud growth|Unknown protein serine/threonine kinase activity incipient cellular bud site|cellular bud|cellular bud neck|cellular bud tip|cytoplasm|cell cortex|nucleus|mating projection tip
YDR397C NCB2 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0941969274659926 4.57592394256578e-08 34 Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter transcription coactivator activity|transcription corepressor activity nucleus|negative cofactor 2 complex
YKR018C YKR018C hom FT NUCLEUS|MITOCHONDRION 0.0940569878382774 4.79120988045811e-08 35 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YMR043W MCM1 het FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|NUCLEUS|CHROMOSOME 0.0931512258841296 6.44153568597417e-08 36 Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes regulation of mating type switching|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|DNA replication initiation|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of mating-type specific transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter DNA replication origin binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II repressing transcription factor binding nuclear chromatin
YKL021C MAK11 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|ENDOMEMBRANE SYSTEM|NUCLEUS 0.0908485956682573 1.35023639155712e-07 37 Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats ribosomal large subunit assembly|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function membrane
YDL031W DBP10 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0887059539941342 2.64602856559986e-07 38 Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ATP-dependent RNA helicase activity nucleolus|preribosome, large subunit precursor
YDL139C SCM3 het FT PROTEIN LOCALIZATION|CELL CYCLE|PROTEOLYSIS|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0847941750950558 8.68799629007057e-07 39 Nonhistone component of centromeric chromatin; binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation; homolog of mammalian HJURP G2/M transition of mitotic cell cycle|chromosome segregation|protein localization to chromosome, centromeric region|Unknown centromere-specific nucleosome binding nucleus|condensed nuclear chromosome, centromeric region|cytoplasm
YGL011C SCL1 het FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION 0.0845884782479992 9.23548323116452e-07 40 Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function mitochondrion|proteasome core complex, alpha-subunit complex|nucleus|proteasome storage granule|nuclear outer membrane-endoplasmic reticulum membrane network
YLR105C SEN2 het FT RNA PROCESSING|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION 0.082643125831571 1.67605287756392e-06 41 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease tRNA-type intron splice site recognition and cleavage tRNA-intron endonuclease activity mitochondrial outer membrane|mitochondrion|tRNA-intron endonuclease complex
YOL022C TSR4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS 0.0823152401864378 1.79768054747808e-06 42 Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2 maturation of SSU-rRNA molecular_function cytoplasm
YPL247C_p YPL247C hom FT NUCLEUS 0.0819063729941683 2.0298880385851e-06 43 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest biological_process molecular_function nucleus|cytoplasm
YMR308C PSE1 het FT PROTEIN LOCALIZATION|CELL CYCLE|RNA LOCALIZATION|NUCLEUS 0.0817487487628687 2.11660257523085e-06 44 Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p mRNA export from nucleus|regulation of protein desumoylation|protein import into nucleus|regulation of mitosis protein transporter activity|nuclear localization sequence binding integral to membrane|nucleus|cytoplasm
YLR314C CDC3 het FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0812914738735485 2.44655460070726e-06 45 Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells septin ring disassembly|maintenance of cell polarity|cell cycle cytokinesis|septin ring assembly structural molecule activity|GTP binding|1-phosphatidylinositol binding mating projection base|septin filament array|cellular bud neck septin ring|septin complex|prospore membrane|ascospore wall
YMR186W HSC82 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION 0.0811690202553599 2.49888913034226e-06 46 Cytoplasmic chaperone of the Hsp90 family; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication protein folding|proteasome assembly|protein refolding|telomere maintenance|'de novo' protein folding|box C/D snoRNP assembly|response to stress unfolded protein binding|ATPase activity, coupled|ATPase activity mitochondrion|plasma membrane|cytoplasm
YIL083C CAB2 het FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.0810716839654905 2.56925150332982e-06 47 Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity) coenzyme A biosynthetic process phosphopantothenate--cysteine ligase activity nucleus|cytoplasm
YNL151C RPC31 het FT NUCLEUS 0.0805320667570563 3.05670686290627e-06 48 RNA polymerase III subunit C31 transcription initiation from RNA polymerase III promoter|tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YLR438C-A LSM3 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0795034124265928 4.00165638235098e-06 49 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex
YDR478W SNM1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.079269619144186 4.2719459067681e-06 50 Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP mRNA cleavage|rRNA processing ribonuclease MRP activity|RNA binding ribonuclease MRP complex
YDR407C TRS120 het FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|GOLGI APPARATUS 0.078957918798707 4.65960632487564e-06 51 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic regulation of Rab GTPase activity|early endosome to Golgi transport|intra-Golgi vesicle-mediated transport Rab guanyl-nucleotide exchange factor activity trans-Golgi network|TRAPP complex|early endosome
YGR036C CAX4 hom FT LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0778724953179215 6.2896896102052e-06 52 Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation lipid biosynthetic process|protein N-linked glycosylation dolichyldiphosphatase activity integral to endoplasmic reticulum membrane|integral to membrane
YKL125W RRN3 het FT NUCLEUS 0.0777803281734981 6.45081031758581e-06 53 Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript core RNA polymerase I binding transcription factor activity|RNA polymerase I transcription factor binding transcription factor activity|RNA polymerase I transcription factor binding|RNA polymerase I core binding nucleolus
YDL102W POL3 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.077623649364644 6.73380318368297e-06 54 Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) lagging strand elongation|RNA-dependent DNA replication|base-excision repair|postreplication repair|DNA replication, removal of RNA primer|nucleotide-excision repair|mismatch repair|maintenance of fidelity involved in DNA-dependent DNA replication|DNA replication|leading strand elongation single-stranded DNA specific 3'-5' exodeoxyribonuclease activity|DNA-directed DNA polymerase activity delta DNA polymerase complex|replication fork
YKL157W APE2 hom FT PROTEOLYSIS|MITOCHONDRION 0.0775391419830376 6.89132919167933e-06 55 Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication peptide catabolic process metalloaminopeptidase activity mitochondrion|extracellular region|cell wall-bounded periplasmic space
YGL213C SKI8 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEUS|CHROMOSOME 0.0765766852550483 8.95281810268367e-06 56 Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay|protein-DNA complex assembly|reciprocal meiotic recombination molecular_function Ski complex|nuclear chromosome
YKL196C YKT6 het FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|MITOCHONDRION|GOLGI APPARATUS|PLASMA MEMBRANE 0.0762660740974726 9.73549773728418e-06 57 Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus intra-Golgi vesicle-mediated transport|vacuole fusion, non-autophagic|vesicle fusion palmitoyltransferase activity|SNAP receptor activity SNARE complex|endosome|mitochondrion|Golgi apparatus|fungal-type vacuole|membrane
YHR167W THP2 hom FT TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION|NUCLEUS 0.0760596196676392 1.02914159488208e-05 58 Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance mRNA export from nucleus|transcription elongation from RNA polymerase II promoter|DNA recombination nucleic acid binding THO complex part of transcription export complex|nucleoplasmic THO complex
YDR082W STN1 het FT NUCLEUS|CHROMOSOME 0.0759206856402557 1.07798916863226e-05 59 Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping telomere capping|negative regulation of telomere maintenance via telomerase single-stranded telomeric DNA binding nuclear telomere cap complex
YLR223C IFH1 het FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0755162383221975 1.19031039340025e-05 60 Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|chromatin silencing at telomere transcription coactivator activity nuclear chromatin|nucleolus|nucleus|CURI complex
YDR416W SYF1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|NUCLEUS 0.0749074135621071 1.39944617753495e-05 61 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans generation of catalytic spliceosome for first transesterification step first spliceosomal transesterification activity|second spliceosomal transesterification activity U2-type post-mRNA release spliceosomal complex|Prp19 complex|U2-type prespliceosome|U2-type catalytic step 1 spliceosome|U2-type catalytic step 2 spliceosome
YFR039C_p YFR039C hom 0.0745919414482917 1.52115649095846e-05 62 Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces biological_process molecular_function cellular_component
YDR418W RPL12B hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0744767465847946 1.5680632039191e-05 63 Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YLR061W RPL22A hom FT TRANSLATION|RIBOSOME 0.0732613288973883 2.17916380249944e-05 64 Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YER012W PRE1 het FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0718754248669375 3.07749934188073e-05 65 Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process endopeptidase activator activity proteasome storage granule|nucleus|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YDR327W_d YDR327W het 0.0716020198674338 3.29927627929512e-05 66 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1 Unknown Unknown Unknown
YDR021W FAL1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0711844446479557 3.66750814193072e-05 67 Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ATP-dependent RNA helicase activity nucleolus|FAl1-SGD1 complex
YDR240C SNU56 het FT RNA PROCESSING|NUCLEUS 0.0707800920498005 4.0610039476084e-05 68 Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex mRNA splicing, via spliceosome mRNA binding commitment complex|U1 snRNP|U2-type prespliceosome
YHR166C CDC23 het FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|CHROMOSOME|UBIQUITIN LIGASE COMPLEX 0.0706315658423154 4.21535108658478e-05 69 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity|cyclin binding anaphase-promoting complex
YDR177W UBC1 het FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS 0.0700012782479904 4.93440740252199e-05 70 Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress spore germination|vesicle organization|endocytosis|ER-associated protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination ubiquitin-protein ligase activity proteasome complex
YJL069C UTP18 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0696721027394792 5.35470382321855e-05 71 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YHR112C YHR112C hom FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.069664490456475 5.36481319280296e-05 72 Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway sulfur compound metabolic process cystathionine beta-lyase activity nucleus|cytoplasm
YFR004W RPN11 het FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION|NUCLEUS|MITOCHONDRION 0.0693457742552564 5.99994547111142e-05 73 Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress protein deubiquitination|proteasomal ubiquitin-dependent protein catabolic process|peroxisome fission|mitochondrial fission metallopeptidase activity|ubiquitin-specific protease activity cytosol|mitochondrion|proteasome storage granule|nucleus|proteasome regulatory particle, lid subcomplex
YLR219W MSC3 hom FT CELL CYCLE|PLASMA MEMBRANE 0.0693222063263815 5.83852256329178e-05 74 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress reciprocal meiotic recombination molecular_function cellular_component
YGL138C_p YGL138C hom 0.0691187208673221 6.13862759611153e-05 75 Putative protein of unknown function; has no significant sequence similarity to any known protein biological_process molecular_function cellular_component
YKR009C FOX2 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS 0.0684841914784558 7.18879321009248e-05 76 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities fatty acid beta-oxidation enoyl-CoA hydratase activity|3-hydroxyacyl-CoA dehydrogenase activity peroxisome
YKL141W SDH3 het FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.067564648042539 8.96185279264861e-05 77 Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle|protein import into mitochondrial inner membrane succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II|mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YGL137W SEC27 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0671027877435757 0.000100133514188528 78 Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP retrograde vesicle-mediated transport, Golgi to ER|late endosome to vacuole transport via multivesicular body sorting pathway|ER to Golgi vesicle-mediated transport ubiquitin binding COPI vesicle coat
YNR017W TIM23 het FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0669371720120931 0.000104427974995776 79 Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel protein import into mitochondrial matrix mitochondrion targeting sequence binding|protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane presequence translocase complex
YMR296C LCB1 het FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0669249853467783 0.000104483573771492 80 Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine sphingolipid biosynthetic process serine C-palmitoyltransferase activity SPOTS complex|serine C-palmitoyltransferase complex
YAL034W-A MTW1 het FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.0661084578898868 0.000126850324745533 81 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly chromosome segregation|protein localization to kinetochore molecular_function nuclear MIS12/MIND type complex|spindle pole
YBR138C_p YBR138C hom 0.0659882496060341 0.000130501287564034 82 Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene biological_process molecular_function cytoplasm
YCL017C NFS1 het FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|COFACTOR METABOLISM|NUCLEUS|MITOCHONDRION 0.0659785907152046 0.000130798903328849 83 Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria cellular iron ion homeostasis|iron-sulfur cluster assembly|mitochondrial tRNA thio-modification|tRNA thio-modification|tRNA wobble uridine modification cysteine desulfurase activity mitochondrion|nucleus
YLL061W MMP1 hom FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.0656484013954567 0.000141365959740644 84 High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p S-methylmethionine transport S-methylmethionine transmembrane transporter activity integral to membrane|plasma membrane
YER134C YER134C hom FT NUCLEUS 0.0649150095572323 0.000167780125437742 85 Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene biological_process acid phosphatase activity nucleus|cytoplasm
YGR178C PBP1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|NUCLEUS|MITOCHONDRION 0.0646486351629895 0.00017847407684085 86 Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress positive regulation of translation|mRNA polyadenylation|stress granule assembly molecular_function mitochondrion|nucleus|polysome|cytoplasmic stress granule|cytoplasm
YFR029W PTR3 het FT PLASMA MEMBRANE 0.0645623506288557 0.000182073261100725 87 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes response to amino acid stimulus molecular_function extrinsic to plasma membrane
YLR397C AFG2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS 0.0643047175807532 0.000193230015571099 88 ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; may be involved in degradation of aberrant mRNAs ribosomal large subunit biogenesis|response to drug ATPase activity intracellular|preribosome, large subunit precursor
YFL045C SEC53 het FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM 0.0635432529568259 0.000235596619056157 89 Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen protein targeting to ER phosphomannomutase activity cytosol
YOR256C TRE2 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT 0.0634123308996409 0.000237039717576887 90 Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway molecular_function cellular_component
YOR362C PRE10 het FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION 0.0633714355732048 0.000239255223312652 91 Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process mRNA binding mitochondrion|proteasome core complex, alpha-subunit complex|nucleus|proteasome storage granule|nuclear outer membrane-endoplasmic reticulum membrane network
YBR089W_d YBR089W het 0.0629115036823242 0.00026554623335355 92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30 Unknown Unknown Unknown
YER072W VTC1 hom FT MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM 0.0629057339300715 0.00026589261919177 93 Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic mRNA binding integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex|intrinsic to vacuolar membrane
YGR047C TFC4 het FT NUCLEUS 0.0628994835428384 0.000266268337580059 94 One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending transcription factor TFIIIC complex
YER038C KRE29 het FT RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0623659615004472 0.000300236918731755 95 Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance DNA repair molecular_function Smc5-Smc6 complex|nucleus|cytoplasm
YDL105W NSE4 het FT RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0623575761710068 0.000303315115832321 96 Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair DNA repair molecular_function Smc5-Smc6 complex|nucleus
YGR223C HSV2 hom FT MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS 0.0619845921554393 0.000326959897362372 97 Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization piecemeal microautophagy of nucleus phosphatidylinositol binding endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YDR468C TLG1 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|GOLGI APPARATUS 0.0618656809344217 0.000335736943327028 98 Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p endocytosis|vesicle fusion SNAP receptor activity trans-Golgi network|SNARE complex|endosome
YLR018C POM34 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0616806066426133 0.000350550662895011 99 Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication nuclear pore organization|protein import into nucleus|spindle pole body duplication associated with nuclear envelope structural constituent of nuclear pore nuclear pore transmembrane ring|integral to membrane|integral to nuclear outer membrane|nuclear pore
YNL310C ZIM17 het FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0612035910376579 0.000388773016731954 100 Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix protein folding|protein stabilization|protein import into mitochondrial matrix|response to unfolded protein|mitochondrion organization chaperone binding mitochondrion|mitochondrial matrix
YMR234W RNH1 hom FT CELL WALL ORG/BIOGENESIS|NUCLEUS 0.0609812844916125 0.000408269072548024 101 Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201) fungal-type cell wall organization|RNA catabolic process ribonuclease H activity intracellular|nucleus
YOR063W RPL3 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0607369933617617 0.000430743845630912 102 Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YBR236C ABD1 het FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS|RNA POL II, HOLOENZYME 0.0602481364233458 0.000479227021247497 103 Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA 7-methylguanosine mRNA capping|transcription from RNA polymerase II promoter mRNA (guanine-N7-)-methyltransferase activity nucleus|DNA-directed RNA polymerase II, holoenzyme
YDR254W CHL4 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE 0.0601845552202758 0.000485894076058139 104 Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15 kinetochore assembly|chromosome segregation|establishment of meiotic sister chromatid cohesion|protein localization to chromosome, centromeric region|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion structural molecule activity condensed nuclear chromosome outer kinetochore
YOL127W RPL25 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0598786217968296 0.000519200076735548 105 Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23 cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YMR049C ERB1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0590801570322044 0.000616411702074114 106 Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 ribosomal large subunit biogenesis|rRNA processing molecular_function PeBoW complex|nucleolus|nucleus|preribosome, large subunit precursor
YFR041C ERJ5 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0589697892191774 0.000635852936218915 107 Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response protein folding molecular_function endoplasmic reticulum
YPL150W_p YPL150W hom FT PROTEIN PHOSPHORYLATION 0.0587098536305782 0.000667019242752753 108 Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study protein phosphorylation protein kinase activity cellular_component
YML077W BET5 het FT VESICLE-MEDIATED TRANSPORT|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.0584376825261716 0.000706648858237834 109 Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi ER to Golgi vesicle-mediated transport Rab guanyl-nucleotide exchange factor activity TRAPP complex
YHR070W TRM5 het FT RNA PROCESSING|NUCLEUS|MITOCHONDRION 0.0583810019584546 0.00072177293487054 110 tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya tRNA methylation tRNA (guanine) methyltransferase activity nucleus|mitochondrial matrix|cytoplasm
YDR499W LCD1 het FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0577285035784538 0.000820413946059279 111 Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress establishment of protein localization|telomere maintenance via telomerase|DNA damage checkpoint damaged DNA binding nuclear chromosome
YDL003W MCD1 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CHROMOSOME 0.0576156174773656 0.000840017431599394 112 Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase double-strand break repair|apoptotic process|response to DNA damage stimulus|mitotic chromosome condensation|establishment of mitotic sister chromatid cohesion chromatin binding condensed nuclear chromosome|mitochondrion|nucleus|nuclear mitotic cohesin complex
YGR245C SDA1 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CYTOSKELETON ORGANIZATION|NUCLEUS 0.0575457288423836 0.000852370832083436 113 Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis ribosomal large subunit biogenesis|ribosomal large subunit export from nucleus|traversing start control point of mitotic cell cycle|actin cytoskeleton organization molecular_function nucleus
YGL139W FLC3 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.0573280690116733 0.000899885861133225 114 Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER FAD transport|transmembrane transport FAD transmembrane transporter activity mitochondrion|integral to membrane|endoplasmic reticulum
YDR263C DIN7 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION 0.057216151682574 0.000922671637699657 115 Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination DNA repair nuclease activity mitochondrion
YMR278W PGM3 hom FT CARBOHYDRATE METABOLISM|NUCLEUS 0.0570085613830947 0.000953092366624857 116 Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential biological_process phosphoglucomutase activity nucleus|cytoplasm
YDR434W GPI17 het FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0570085599851817 0.00095309264251259 117 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog attachment of GPI anchor to protein GPI-anchor transamidase activity integral to membrane|endoplasmic reticulum|GPI-anchor transamidase complex
YKL203C TOR2 het FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION|MITOCHONDRION|PLASMA MEMBRANE 0.0569583397566594 0.000963051803499297 118 PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication G1 phase of mitotic cell cycle|regulation of cell cycle|actin filament reorganization involved in cell cycle|positive regulation of endocytosis|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity|Rho protein signal transduction|ribosome biogenesis|signal transduction|TOR signaling cascade|cytoskeleton organization|negative regulation of autophagy protein binding|protein serine/threonine kinase activity TORC1 complex|TORC2 complex|mitochondrion|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|plasma membrane|cytoplasm
YBR109C CMD1 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0569307944201351 0.000968555138661886 119 Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin karyogamy involved in conjugation with cellular fusion|phosphatidylinositol biosynthetic process|NLS-bearing substrate import into nucleus|microautophagy|cell budding|vacuole fusion, non-autophagic|receptor-mediated endocytosis|cytoskeleton organization|spindle pole body organization|transcription factor import into nucleus calcium-dependent protein binding|protein binding|calcium ion binding incipient cellular bud site|central plaque of spindle pole body|mating projection tip|cellular bud neck|cellular bud tip
YOR310C NOP58 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0566569661252971 0.00103201487511586 120 Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function box C/D snoRNP complex|small-subunit processome|nucleolus|90S preribosome
YOL119C MCH4 hom 0.0559936438022304 0.00117407329599987 121 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport transport monocarboxylic acid transmembrane transporter activity|transporter activity fungal-type vacuole membrane|integral to membrane
YMR218C TRS130 het FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|GOLGI APPARATUS 0.055804597707323 0.00123047650912736 122 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy regulation of Rab GTPase activity|early endosome to Golgi transport|intra-Golgi vesicle-mediated transport Rab guanyl-nucleotide exchange factor activity TRAPP complex|trans-Golgi network|early endosome
YLR071C RGR1 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0555673470932872 0.001280294323259 123 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding core mediator complex
YPL216W_p YPL216W hom FT CHROMATIN ORGANIZATION|NUCLEUS 0.0554309365597023 0.00131611322762124 124 Putative protein of unknown function; YPL216W is not an essential gene biological_process molecular_function cellular_component
YHR122W CIA2 het FT CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS 0.0553913539218554 0.00132667861011618 125 Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B establishment of mitotic sister chromatid cohesion molecular_function nucleus|cytoplasm
YFR050C PRE4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0550523681163478 0.00142744900050127 126 Beta 7 subunit of the 20S proteasome proteasome assembly|proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YBR276C PPS1 hom FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0548918716528237 0.00146689378388919 127 Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle inactivation of MAPK activity|protein dephosphorylation|regulation of S phase of mitotic cell cycle protein tyrosine/serine/threonine phosphatase activity cellular_component
YGR048W UFD1 het FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0546965059436086 0.00153281903468095 128 Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP) retrograde protein transport, ER to cytosol|proteasomal ubiquitin-dependent protein catabolic process|ER-associated protein catabolic process|ER-associated misfolded protein catabolic process|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process ubiquitin binding|polyubiquitin binding nucleus|Cdc48p-Npl4p-Ufd1p AAA ATPase complex
YIL117C PRM5 hom 0.0544336497259413 0.0016074059518987 129 Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling biological_process molecular_function integral to membrane
YJR115W_p YJR115W hom 0.0544057425438823 0.0016241791555584 130 Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication biological_process molecular_function cellular_component
YHR118C ORC6 het FT GENE SILENCING|NUCLEUS|CHROMOSOME 0.0541249709404065 0.00170893205615361 131 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p DNA replication initiation|pre-replicative complex assembly|chromatin silencing at silent mating-type cassette DNA replication origin binding pre-replicative complex|DNA replication preinitiation complex|nuclear origin of replication recognition complex
YMR160W YMR160W hom 0.0539377664938168 0.00177334286364601 132 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress biological_process molecular_function fungal-type vacuole membrane
YHR186C KOG1 het FT SIGNALING|RESPONSE TO NUTRIENT LEVELS|MITOCHONDRION|PLASMA MEMBRANE 0.0537407584132287 0.00184352975631527 133 Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors TOR signaling cascade|regulation of cell growth|cellular response to starvation ubiquitin binding TORC1 complex|fungal-type vacuole membrane|mitochondrion|plasma membrane
YCL044C MGR1 hom FT PROTEOLYSIS|MITOCHONDRION 0.0536891366023713 0.00188589524280766 134 Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA misfolded or incompletely synthesized protein catabolic process misfolded protein binding mitochondrion|i-AAA complex
YJR107W_p YJR107W hom FT LIPID METABOLISM 0.0533800101685311 0.00197870213626191 135 Putative lipase biological_process lipase activity cellular_component
YJL167W ERG20 het FT LIPID METABOLISM|ENDOPLASMIC RETICULUM 0.0533273795711569 0.00201786417245878 136 Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis farnesyl diphosphate biosynthetic process|ergosterol biosynthetic process|isoprenoid biosynthetic process dimethylallyltranstransferase activity|geranyltranstransferase activity endoplasmic reticulum|cytoplasm
YGL150C INO80 het FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0529197433024732 0.0021643587561181 137 ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription nucleosome positioning|histone exchange|transcription from RNA polymerase II promoter|DNA repair|nucleosome mobilization|chromatin remodeling|chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter ATPase activity|ATP-dependent 3'-5' DNA helicase activity Ino80 complex
YAR003W SWD1 hom FT CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.052891888616781 0.00217609106597924 138 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 histone H3-K4 methylation|telomere maintenance|regulation of transcription, DNA-dependent|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YJL143W TIM17 het FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0528820796453677 0.00218023642913016 139 Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex protein import into mitochondrial matrix|mitochondrial genome maintenance protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane presequence translocase complex
YJL132W_p YJL132W hom 0.0528669158317431 0.00218665903889763 140 Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene biological_process molecular_function membrane
YDR318W MCM21 hom FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE 0.0527262687353503 0.00224706123586952 141 Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function COMA complex|condensed nuclear chromosome kinetochore
YLL051C FRE6 hom FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.0526375919259053 0.00228939034224522 142 Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels intracellular sequestering of iron ion|copper ion import ferric-chelate reductase activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YMR086W SEG1 hom 0.0525290625963981 0.00233432839471067 143 Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes biological_process molecular_function eisosome|ribosome|cytoplasm
YKR033C_d YKR033C hom 0.0522256990046518 0.00247464289695137 144 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80 Unknown Unknown Unknown
YOL134C_d YOL134C het 0.0517257953907389 0.00272278016033894 145 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit Unknown Unknown Unknown
YJR151W-A_p YJR151W-A hom 0.0512504668685872 0.00299681535810396 146 Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational guilt by association analysis biological_process molecular_function cellular_component
YLR026C SED5 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.051125176169211 0.00305524153110326 147 cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|cis-Golgi network
YNL227C JJJ1 hom FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION|RIBOSOME 0.0511223681013465 0.00305247596885767 148 Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|endocytosis|regulation of cell size|rRNA processing ATPase activator activity cytosol|mitochondrion|cytosolic large ribosomal subunit|nucleolus|cytoplasm
YGR253C PUP2 het FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION 0.050977958764724 0.00315905678370294 149 Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YKR029C SET3 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.0507179037940538 0.00329341678128151 150 Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation methylated histone residue binding Rpd3L-Expanded complex|Set3 complex
YGR266W YGR266W hom FT MITOCHONDRION|PLASMA MEMBRANE 0.0505666818363059 0.00338786017537431 151 Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrial outer membrane|mitochondrion|plasma membrane
YGL217C_d YGL217C hom 0.0505196751408102 0.00341771575095978 152 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W Unknown Unknown Unknown
YOR096W RPS7A hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS|RIBOSOME 0.0504422754526077 0.00346739698485924 153 Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication cytoplasmic translation|ribosome biogenesis structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YPL096W PNG1 hom FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS|MITOCHONDRION 0.050432092711374 0.00347398174720355 154 Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p misfolded or incompletely synthesized protein catabolic process|protein deglycosylation peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity cytosol|mitochondrion|nucleus
YPL244C HUT1 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0499232733404156 0.00383362427082931 155 Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 UDP-galactose transport|UDP-glucose transport UDP-galactose transmembrane transporter activity integral to membrane
YPR148C YPR148C hom 0.0497141512683873 0.00396794977840142 156 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function ribosome|cytoplasm
YHL015W RPS20 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0495285085220182 0.00410565062631556 157 Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10 cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YNL091W NST1 hom 0.0494578819932934 0.0041591662087719 158 Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1 response to salt stress molecular_function cytoplasm
YDR355C_d YDR355C het 0.0491358351640419 0.00445861528242919 159 Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W Unknown Unknown Unknown
YBL023C MCM2 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0488653939457207 0.00463363583731486 160 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|pre-replicative complex assembly|double-strand break repair via break-induced replication chromatin binding|DNA replication origin binding|DNA helicase activity|single-stranded DNA binding replication fork protection complex|nucleus|DNA replication preinitiation complex|pre-replicative complex|cytoplasm|MCM complex
YPL038W-A_p YPL038W-A hom 0.0487860952329509 0.00470072622114417 161 Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YDR105C TMS1 hom 0.0486877910740484 0.00478511575942594 162 Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance biological_process molecular_function fungal-type vacuole membrane|integral to membrane|membrane
YPL107W_p YPL107W hom FT MITOCHONDRION 0.0486118437934893 0.00485124871384499 163 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene biological_process molecular_function mitochondrion
YER168C CCA1 het FT RNA PROCESSING|NUCLEUS|MITOCHONDRION 0.0485902220773667 0.00487022691726189 164 ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites tRNA 3'-terminal CCA addition tRNA adenylyltransferase activity mitochondrion|nucleus|mitochondrial matrix|cytoplasm
YGL048C RPT6 het FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS 0.0480461084594176 0.0053704680370562 165 ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|nucleotide-excision repair|proteasome regulatory particle assembly|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of sequence-specific DNA binding transcription factor activity|chromatin remodeling ATPase activity|protein domain specific binding proteasome regulatory particle, base subcomplex|proteasome storage granule|nucleus
YNL163C RIA1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM 0.0479895498596175 0.00543197270582801 166 Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes mature ribosome assembly GTPase activity cytoplasm
YLR005W SSL1 het FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME 0.0478333456567686 0.00559965303318585 167 Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p phosphorylation of RNA polymerase II C-terminal domain|translational initiation|nucleotide-excision repair|transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YKL129C MYO3 hom FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON 0.0476127290474638 0.00583086765495756 168 One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization bipolar cellular bud site selection|fungal-type cell wall organization|endocytosis|exocytosis|actin cortical patch localization|response to osmotic stress microfilament motor activity actin cortical patch
YIL142W CCT2 het 0.047317995336133 0.00611234398645112 169 Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo protein folding unfolded protein binding chaperonin-containing T-complex|cytoplasm
YLR282C_d YLR282C hom 0.0472307008401013 0.00623035698297041 170 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Unknown Unknown Unknown
YMR107W SPG4 hom 0.0471122930474566 0.00633802665633144 171 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources biological_process molecular_function cellular_component
YNL049C SFB2 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.046999689294226 0.00649658056039283 172 Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p cargo loading into COPII-coated vesicle signal sequence binding COPII vesicle coat
YPL067C_p YPL067C hom 0.0469766134570038 0.00649095965651607 173 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene biological_process molecular_function cytoplasm
YBR155W CNS1 het 0.046767614230926 0.00673303369361153 174 TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion protein folding Hsp70 protein binding|Hsp90 protein binding cytoplasm
YBL035C POL12 het FT ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME 0.0466002856707936 0.00693265596541635 175 B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation telomere capping|lagging strand elongation|DNA replication initiation DNA-directed DNA polymerase activity nuclear envelope|alpha DNA polymerase:primase complex|nucleus
YOL139C CDC33 het FT CELL CYCLE|TRANSLATION|NUCLEUS|RIBOSOME 0.0465604527573404 0.00698095269794158 176 mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth regulation of cell cycle|translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay phosphatidylinositol-3-phosphate binding|translation initiation factor activity ribosome|nucleus|eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule|cytoplasm
YER094C PUP3 het FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0464995638880344 0.0070553633162313 177 Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process endopeptidase activator activity proteasome storage granule|nucleus|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YPR181C SEC23 het FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.0464410064538091 0.00712759546301768 178 GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p regulation of COPII vesicle coating GTPase activator activity COPII vesicle coat
YJL060W BNA3 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION 0.0460136210783652 0.00767519688574915 179 Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate kynurenic acid biosynthetic process arylformamidase activity|kynurenine-oxoglutarate transaminase activity mitochondrion|cytoplasm
YCR072C RSA4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.0459233892048851 0.00779551867421697 180 WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus ribosomal large subunit assembly molecular_function ribosome|nucleolus
YBL091C MAP2 hom FT PROTEOLYSIS 0.0458495451391971 0.00789524170851189 181 Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p protein initiator methionine removal involved in protein maturation metalloaminopeptidase activity cytoplasm
YJL176C SWI3 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|RSC COMPLEX 0.0457192628825728 0.00807397024252098 182 Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter histone binding|DNA binding SWI/SNF complex|nucleus
YOR027W STI1 hom 0.0455743727367436 0.0082769835609857 183 Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop protein folding Hsp70 protein binding|Hsp90 protein binding|mRNA binding|ATPase inhibitor activity cytoplasm
YDR262W_p YDR262W hom 0.0455416858649281 0.00832340925155708 184 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment biological_process molecular_function fungal-type vacuole
YDR053W_d YDR053W het 0.0454031264630888 0.00852280350588044 185 Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex Unknown Unknown Unknown
YBL088C TEL1 hom FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|MITOCHONDRION|CHROMOSOME 0.0452219765635367 0.00883029543377035 186 Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585) double-strand break repair|histone phosphorylation|telomere maintenance|response to DNA damage stimulus|phosphorylation|DNA damage induced protein phosphorylation protein kinase activity|telomeric DNA binding mitochondrion|nucleus
YML069W POB3 het FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.045142399916397 0.00890960945996481 187 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress DNA replication-independent nucleosome organization|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|regulation of transcription by chromatin organization|DNA-dependent DNA replication chromatin binding|nucleosome binding|histone binding nuclear chromatin|FACT complex|replication fork protection complex|alpha DNA polymerase:primase complex
YDR217C RAD9 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0450069632278975 0.0091166613852432 188 DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of cell cycle|intra-S DNA damage checkpoint|nucleotide-excision repair|DNA damage checkpoint|positive regulation of transcription from RNA polymerase II promoter double-stranded DNA binding|histone binding chromatin|nucleus
YGR065C VHT1 het FT PLASMA MEMBRANE 0.0447754669023892 0.00952328871193515 189 High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin biotin transport biotin transporter activity integral to membrane|plasma membrane
YBR267W REI1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION|RIBOSOME 0.0446516468962173 0.00968040994429359 190 Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network ribosomal large subunit biogenesis|nucleocytoplasmic transport|mitotic cell cycle|budding cell bud growth sequence-specific DNA binding cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YOL152W FRE7 hom FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|PLASMA MEMBRANE 0.0446005359209707 0.0097640086484532 191 Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels iron ion transport|copper ion import ferric-chelate reductase activity integral to membrane|plasma membrane
YPL154C PEP4 hom FT MEMBRANE ORGANIZATION|PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS|MITOCHONDRION 0.044521910916401 0.00989386606017952 192 Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates microautophagy|proteolysis involved in cellular protein catabolic process|cellular response to starvation peptidase activity fungal-type vacuole lumen|mitochondrion|fungal-type vacuole
YDL243C AAD4 hom FT OXIDATION-REDUCTION PROCESS 0.0444504594142838 0.0100577792117525 193 Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YER112W LSM4 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0441186444155078 0.0105959759311915 194 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|cytoplasmic mRNA processing body assembly U6 snRNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|cytoplasmic mRNA processing body|U4/U6 x U5 tri-snRNP complex
YBR042C CST26 hom FT LIPID METABOLISM 0.0440444163742226 0.0107160457918819 195 Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication phospholipid biosynthetic process transferase activity, transferring acyl groups lipid particle
YGR064W_d YGR064W hom FF 0.0439309566075473 0.0109201203018144 196 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C Unknown Unknown Unknown
YLR376C PSY3 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.0437794969176024 0.0111979207509294 197 Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C recombinational repair|error-free translesion synthesis molecular_function nucleus|Shu complex|cytoplasm
YDR301W CFT1 het FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS|MITOCHONDRION 0.0435537300595273 0.0116236601939021 198 RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF mRNA cleavage|termination of RNA polymerase II transcription|mRNA polyadenylation RNA binding mRNA cleavage factor complex|mitochondrion|mRNA cleavage and polyadenylation specificity factor complex
YNL038W GPI15 het FT LIPID METABOLISM|ENDOPLASMIC RETICULUM 0.0433368007447028 0.0120589751933827 199 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein GPI anchor biosynthetic process phosphatidylinositol N-acetylglucosaminyltransferase activity glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane
YPR168W NUT2 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0432991552649931 0.012120890348817 200 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter molecular_function core mediator complex
YER022W SRB4 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0432490039972423 0.0122210371595798 201 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination transcription initiation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter activating transcription factor binding|structural molecule activity|core RNA polymerase II recruiting transcription factor activity core mediator complex
YHR026W VMA16 hom FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS 0.0432071192982781 0.0123442338838696 202 Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YDR271C_d YDR271C hom 0.0429241493804331 0.0128876680522442 203 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W Unknown Unknown Unknown
YJL156C SSY5 het FT PROTEOLYSIS|PLASMA MEMBRANE 0.0427841153891599 0.0131984815016746 204 Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p protein processing|response to amino acid stimulus serine-type endopeptidase activity extrinsic to plasma membrane
YAL046C AIM1 hom 0.0427282688791429 0.0133187561105865 205 Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function cellular_component
YPR026W ATH1 hom FT CARBOHYDRATE METABOLISM 0.0426827310732123 0.0134037099348823 206 Acid trehalase required for utilization of extracellular trehalose trehalose catabolic process|response to stress alpha,alpha-trehalase activity fungal-type cell wall|cell wall-bounded periplasmic space|fungal-type vacuole
YOL128C YGK3 hom FT PROTEOLYSIS|PROTEIN PHOSPHORYLATION 0.0426657204339627 0.0135381021085343 207 Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation proteolysis|protein phosphorylation|response to stress protein serine/threonine kinase activity|protein kinase activity cellular_component
YOR332W VMA4 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS 0.0424868868294996 0.0139351117596432 208 Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane|integral to membrane
YOR371C GPB1 hom FT SIGNALING|PROTEOLYSIS|PLASMA MEMBRANE 0.0424414353118543 0.0139376449801985 209 Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication positive regulation of Ras protein signal transduction|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of phosphorylation|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|invasive growth in response to glucose limitation|negative regulation of Ras protein signal transduction|protein polyubiquitination cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding plasma membrane|cytoplasm
YDR427W RPN9 het FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS 0.0423754262668948 0.0140869401794871 210 Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress proteasome assembly|ubiquitin-dependent protein catabolic process structural molecule activity proteasome storage granule|proteasome regulatory particle, lid subcomplex
YOL061W PRS5 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 0.0423604689452267 0.0141209651335314 211 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YHR019C DED81 het FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION 0.0423167686503855 0.0142641914768414 212 Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA asparaginyl-tRNA aminoacylation asparagine-tRNA ligase activity cytosol
YLR294C_d YLR294C hom 0.0422616187781871 0.0143476578886515 213 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14 Unknown Unknown Unknown
YMR251W-A HOR7 hom FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.0422486024050469 0.0144214987005135 214 Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication plasma membrane organization molecular_function endoplasmic reticulum|plasma membrane
YBL074C AAR2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS 0.0420507132453038 0.0148420799391625 215 Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron assembly of spliceosomal tri-snRNP molecular_function U5 snRNP
YHR147C MRPL6 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0419537050267406 0.0151652235852408 216 Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YOR117W RPT5 het FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS 0.0419399160907799 0.015229082205041 217 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process ATPase activity proteasome regulatory particle, base subcomplex
YHL006C SHU1 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.0419395385242395 0.0151086968432039 218 Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function recombinational repair|maintenance of rDNA molecular_function nucleolus|Shu complex
YNL329C PEX6 hom FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION 0.0418316709847827 0.0153714033024319 219 AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol protein import into peroxisome matrix, receptor recycling|replicative cell aging ATPase activity|protein heterodimerization activity cytosol|peroxisome
YPR007C REC8 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0417924173709445 0.0154679963609626 220 Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p synaptonemal complex assembly|protein localization to chromosome, centromeric region|reciprocal meiotic recombination|meiotic sister chromatid cohesion molecular_function condensed nuclear chromosome|condensed nuclear chromosome, centromeric region
YOL151W GRE2 hom FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS 0.0417520589953231 0.0155678642739164 221 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress ergosterol metabolic process|filamentous growth methylglyoxal reductase (NADPH-dependent) activity|3-methylbutanol:NAD(P) oxidoreductase activity nucleus|cytoplasm
YJR108W ABM1 hom FT CYTOSKELETON ORGANIZATION 0.0414940743073771 0.0162197566926162 222 Protein of unknown function, required for normal microtubule organization microtubule cytoskeleton organization molecular_function cellular_component
YOR274W MOD5 hom FT RNA PROCESSING|NUCLEUS|MITOCHONDRION 0.0412731880444124 0.0167968375366367 223 Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis tRNA modification tRNA dimethylallyltransferase activity cytosol|mitochondrion|nucleolus|nucleus
YLR093C NYV1 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION 0.0411870566870299 0.017026697834914 224 v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane vesicle-mediated transport|vacuole fusion, non-autophagic|vesicle fusion SNAP receptor activity SNARE complex|fungal-type vacuole membrane
YGL235W_p YGL235W hom 0.0411704769256278 0.0170712598311778 225 Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 biological_process molecular_function cellular_component
YPL242C IQG1 het FT CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0410879336775564 0.0172946397078428 226 Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress actin filament organization|response to osmotic stress|cytokinesis cytoskeletal protein binding cellular bud neck contractile ring
YMR130W_p YMR130W hom 0.0410591285379954 0.0173731935796319 227 Putative protein of unknown function; YMR130W is not an essential gene biological_process molecular_function cellular_component
YIL074C SER33 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 0.0410306430681707 0.0174511830688565 228 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication serine family amino acid biosynthetic process phosphoglycerate dehydrogenase activity cytoplasm
YLR429W CRN1 hom FT CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.0409894796037501 0.0175644252663104 229 Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly microtubule-based process|actin filament organization|actin cortical patch localization|Unknown|negative regulation of Arp2/3 complex-mediated actin nucleation microtubule binding|actin filament binding|protein binding, bridging Arp2/3 protein complex|actin cortical patch
YBR274W CHK1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0408411801121661 0.0179777583923938 230 Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase protein phosphorylation|replication fork protection|DNA damage checkpoint protein serine/threonine kinase activity nucleus
YPR103W PRE2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0407853022213899 0.0181356934365018 231 Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome proteasomal ubiquitin-dependent protein catabolic process|proteasome core complex assembly|proteasomal ubiquitin-independent protein catabolic process endopeptidase activity nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YOR028C CIN5 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0407344790422679 0.0182803949776283 232 Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication hyperosmotic salinity response|response to drug|hyperosmotic response|regulation of transcription from RNA polymerase II promoter repressing transcription factor binding|sequence-specific DNA binding nucleus|cytoplasm
YFR027W ECO1 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0406654308765716 0.0184786041442975 233 Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress double-strand break repair|regulation of DNA replication|mitotic chromosome condensation|internal peptidyl-lysine acetylation|establishment of mitotic sister chromatid cohesion|DNA repair|chromosome organization|DNA replication|regulation of mitosis|telomere organization|tRNA gene clustering acetyltransferase activity|chromatin binding nuclear chromatin|nuclear replication fork
YPR094W RDS3 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS 0.0404243834978016 0.0191853654001209 234 Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance spliceosomal complex assembly|response to xenobiotic stimulus|mRNA splicing, via spliceosome molecular_function U2 snRNP
YOR379C_d YOR379C hom 0.0403321186070917 0.0195529597774561 235 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W Unknown Unknown Unknown
YLR355C ILV5 het FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0403217344808686 0.0194934359674559 236 Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids mitochondrial genome maintenance|branched-chain amino acid biosynthetic process double-stranded DNA binding|ketol-acid reductoisomerase activity mitochondrial nucleoid|mitochondrion
YHR123W EPT1 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.0401410185621253 0.0200463069684509 237 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolaminephosphotransferase activity|diacylglycerol cholinephosphotransferase activity integral to membrane|Golgi apparatus
YDR445C_d YDR445C hom 0.0401315041205646 0.0200757901919314 238 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR131C RRB1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0401210951545004 0.0201080886785496 239 Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p ribosome biogenesis molecular_function nucleolus
YNL318C HXT14 hom FT MITOCHONDRION|PLASMA MEMBRANE 0.0400954897984825 0.0201877337445268 240 Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies hexose transport galactose transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YGL007C-A_p YGL007C-A hom 0.0400674268972844 0.0202753388556419 241 Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding biological_process molecular_function cellular_component
YIL132C CSM2 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS 0.0400110165911293 0.0204524407009417 242 Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis meiotic chromosome segregation|recombinational repair|maintenance of rDNA|error-free translesion synthesis molecular_function nucleus|Shu complex|cytoplasm
YMR246W FAA4 hom FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM 0.0399640938895731 0.0206007818912962 243 Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process long-chain fatty acid-CoA ligase activity lipid particle|cytoplasm
YNL247W YNL247W het FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION 0.039810431922116 0.0210931512296173 244 Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments cysteinyl-tRNA aminoacylation cysteine-tRNA ligase activity ribosome|cytoplasm
YFR008W FAR7 hom FT CELL CYCLE|SIGNALING 0.0397702588109513 0.0213008348662618 245 Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress re-entry into mitotic cell cycle after pheromone arrest molecular_function cellular_component
YLL059C_d YLL059C hom 0.0395937046732454 0.0218050032508645 246 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR206W NOC2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION 0.039588226755463 0.0219218289128782 247 Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors ribosomal subunit export from nucleus|ribosome assembly molecular_function mitochondrion|nucleus|Noc2p-Noc3p complex|Noc1p-Noc2p complex
YAR002W NUP60 hom FT PROTEIN LOCALIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0394196372148737 0.0223917795197752 248 FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153 double-strand break repair|poly(A)+ mRNA export from nucleus|protein export from nucleus|regulation of protein desumoylation|intracellular mRNA localization|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|chromosome organization|nucleocytoplasmic transport|chromatin silencing at silent mating-type cassette nucleocytoplasmic transporter activity|phospholipid binding|structural constituent of nuclear pore nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YLR035C MLH2 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS 0.0393940127312863 0.0224793074130877 249 Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p mismatch repair|reciprocal meiotic recombination molecular_function nucleus
YBR149W ARA1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM 0.0393666487051807 0.0225731053122584 250 NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product cellular carbohydrate metabolic process alditol:NADP+ 1-oxidoreductase activity|D-arabinose 1-dehydrogenase [NAD(P)+] activity cytosol
YBL092W RPL32 het FF|FT TRANSLATION|RIBOSOME 0.0393142894852178 0.022895758611076 251 Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPL204W HRR25 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION|NUCLEUS|SITE OF POLARIZED GROWTH|P 0.039290404529569 0.0228362493646993 252 Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) ribosomal small subunit biogenesis|DNA repair|mitosis|ER to Golgi vesicle-mediated transport|protein phosphorylation|attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation|tRNA wobble uridine modification protein serine/threonine kinase activity|protein kinase activity chromosome, centromeric region|plasma membrane|nucleus|spindle pole body|monopolin complex|cellular bud neck|cellular bud tip
YLR010C TEN1 het FT NUCLEUS|CHROMOSOME 0.0388446073826479 0.0244287877387445 253 Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p negative regulation of telomere maintenance|telomere capping|telomere maintenance via telomerase single-stranded telomeric DNA binding nuclear telomere cap complex
YCL022C_d YCL022C hom 0.0388266314215976 0.0244949734030711 254 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W Unknown Unknown Unknown
YOL164W-A_p YOL164W-A hom 0.038809248215426 0.0245804960085596 255 Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YBR115C LYS2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 0.0387663475592835 0.0247180675287962 256 Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p lysine biosynthetic process via aminoadipic acid L-aminoadipate-semialdehyde dehydrogenase activity cytoplasm
YBR010W HHT1 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0386867340918613 0.0250153896447553 257 Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint DNA binding replication fork protection complex|nucleus|nuclear nucleosome
YOR266W PNT1 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0386746431047352 0.0250608139448998 258 Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine protein insertion into mitochondrial membrane from inner side molecular_function mitochondrion|integral to mitochondrial inner membrane
YJL001W PRE3 het FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0386725017853266 0.025068866045202 259 Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process endopeptidase activity nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YEL061C CIN8 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.0386334977026519 0.0252159271464588 260 Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation mitotic anaphase B|microtubule depolymerization|spindle pole body separation|mitotic spindle organization in nucleus|mitotic sister chromatid segregation plus-end-directed microtubule motor activity|minus-end-directed microtubule motor activity spindle microtubule|kinesin complex|mitochondrion|condensed nuclear chromosome kinetochore|kinetochore microtubule|astral microtubule
YAL008W FUN14 hom FT MITOCHONDRION 0.0386243357982409 0.025250579272731 261 Mitochondrial protein of unknown function biological_process molecular_function mitochondrial outer membrane|mitochondrion
YOR166C SWT1 hom FT NUCLEUS 0.0385438548661646 0.0255567484570212 262 RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain nuclear mRNA surveillance of mRNP export|transcription, DNA-dependent endoribonuclease activity nucleus|cytoplasm
YOL109W ZEO1 hom FT CELL WALL ORG/BIOGENESIS|MITOCHONDRION|PLASMA MEMBRANE 0.0384980253249976 0.0257325257061453 263 Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria fungal-type cell wall organization|response to stress molecular_function mitochondrial outer membrane|mitochondrion|extrinsic to plasma membrane|plasma membrane
YLR024C UBR2 hom 0.0383422060738855 0.0263380038818461 264 Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex protein monoubiquitination ubiquitin-protein ligase activity cytoplasm
YBR152W SPP381 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS 0.038337029769204 0.0263583272446928 265 mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step molecular_function U4/U6 x U5 tri-snRNP complex
YPR054W SMK1 hom FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION|MITOCHONDRION 0.0383171503599563 0.0264365043228877 266 Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p ascospore wall assembly|protein phosphorylation|negative regulation of sporulation resulting in formation of a cellular spore MAP kinase activity mitochondrion
YOL062C APM4 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE 0.0382193164382228 0.0268468820890364 267 Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport intracellular protein transport|vesicle-mediated transport molecular_function AP-2 adaptor complex
YHL003C LAG1 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0381636235218952 0.0271385307761836 268 Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress replicative cell aging|ceramide biosynthetic process sphingosine N-acyltransferase activity integral to membrane|endoplasmic reticulum
YLR410W VIP1 hom FT CYTOSKELETON 0.0380229642610997 0.0276170286308726 269 Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1 inositol phosphate biosynthetic process inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 4-kinase activity|inositol hexakisphosphate 6-kinase activity cytoplasm
YLR017W MEU1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.0379614581046349 0.0278695076876296 270 Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression L-methionine salvage from methylthioadenosine|glutamate biosynthetic process S-methyl-5-thioadenosine phosphorylase activity|mRNA binding cytoplasm
YDL220C CDC13 het FT CELL CYCLE|CELL DIVISION|NUCLEUS|CHROMOSOME 0.0379036832190195 0.0281084793941637 271 Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation telomere capping|telomere maintenance via telomerase|negative regulation of telomerase activity|telomere maintenance|regulation of telomere maintenance via telomerase single-stranded telomeric DNA binding|telomerase inhibitor activity nuclear telomere cap complex
YPL231W FAS2 het FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.0378386950975047 0.0283793945026253 272 Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities fatty acid biosynthetic process holo-[acyl-carrier-protein] synthase activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|fatty acid synthase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity cytosol|fatty acid synthase complex|mitochondrion|cytoplasm
YGR093W_p YGR093W hom FT NUCLEUS 0.0378208753666786 0.0284540710360539 273 Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus biological_process molecular_function nucleus
YML122C_d YML122C hom FF 0.0375331860994374 0.0299767715672929 274 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL118W RHO3 het FT VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE 0.0374175298421668 0.0301901856424129 275 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p positive regulation of formin-nucleated actin cable assembly|establishment or maintenance of actin cytoskeleton polarity|positive regulation of exocytosis GTP binding|GTPase activity cytosol|plasma membrane|cellular bud
YCR057C PWP2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION|NUCLEUS 0.0373368363241558 0.030672532450232 276 Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|establishment of cell polarity|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytokinesis snoRNA binding small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|cytoplasm|90S preribosome
YJL068C YJL068C hom 0.0372478792904343 0.03094715436189 277 Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D formaldehyde catabolic process S-formylglutathione hydrolase activity cytosol
YAR035C-A_p YAR035C-A hom 0.0371706761598092 0.0312969856120329 278 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis biological_process molecular_function cellular_component
YOR331C_d YOR331C hom 0.0371657065875196 0.0313196200017663 279 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W Unknown Unknown Unknown
YBL071C-B_p YBL071C-B hom 0.0371191764308209 0.0315575825202076 280 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YCR063W BUD31 hom FT CELL CYCLE|RNA PROCESSING|CELL DIVISION|NUCLEUS 0.0370610725643017 0.0317994553240425 281 Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis RNA splicing|mRNA splicing, via spliceosome|cellular bud site selection molecular_function U2 snRNP|nucleus
YGR247W CPD1 hom FT NUCLEOTIDE METABOLISM|GOLGI APPARATUS 0.0370447011344318 0.0318750992791482 282 Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress cyclic nucleotide metabolic process 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity clathrin-coated vesicle
YOL031C SIL1 hom FT PROTEIN LOCALIZATION|ENDOPLASMIC RETICULUM 0.0369466666236739 0.0323828892037645 283 Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein SRP-dependent cotranslational protein targeting to membrane, translocation adenyl-nucleotide exchange factor activity endoplasmic reticulum
YNL258C DSL1 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0369067489783321 0.0325445350688707 284 Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p; similar to the fly and human ZW10 gene retrograde vesicle-mediated transport, Golgi to ER|ER-dependent peroxisome organization molecular_function Dsl1p complex|endoplasmic reticulum|peroxisome|nucleus
YGL116W CDC20 het FF|FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0368531327902436 0.0327717580893525 285 Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress spindle checkpoint|activation of mitotic anaphase-promoting complex activity|meiotic anaphase I|positive regulation of protein catabolic process|activation of anaphase-promoting complex activity involved in meiotic cell cycle|positive regulation of mitotic metaphase/anaphase transition|cyclin catabolic process anaphase-promoting complex binding|ubiquitin-protein ligase activator activity mitotic checkpoint complex|anaphase-promoting complex
YKL053W_d YKL053W hom 0.0368135025920725 0.032986041028698 286 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1 Unknown Unknown Unknown
YJL033W HCA4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.036678054181962 0.0336894760654228 287 DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis rRNA processing RNA-dependent ATPase activity|ATP-dependent RNA helicase activity nucleolus
YMR277W FCP1 het FF|FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0365719831336835 0.034153490192845 288 Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) dephosphorylation of RNA polymerase II C-terminal domain|regulation of transcription from RNA polymerase II promoter protein serine/threonine phosphatase activity nucleus
YDL088C ASM4 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0365564358225067 0.0342030669499543 289 FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication nuclear pore organization|mRNA export from nucleus in response to heat stress|mitotic cell cycle spindle assembly checkpoint nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding nuclear pore central transport channel|integral to membrane|nuclear pore
YMR142C RPL13B hom FT TRANSLATION|RIBOSOME 0.0365002622949248 0.0344799849990778 290 Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPL109C_p YPL109C hom FT MITOCHONDRION 0.0364744346962699 0.0346079481758605 291 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YMR314W PRE5 het FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION 0.036442447528887 0.0349025197534484 292 Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YGL112C TAF6 het FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE 0.0362545861530347 0.0357136981536543 293 Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4 histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter chromatin binding|RNA polymerase II activating transcription factor binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YDR532C KRE28 hom FT ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.0361978066749744 0.0360041225402673 294 Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components biological_process molecular_function chromosome, centromeric region|condensed nuclear chromosome kinetochore|spindle pole body
YBL026W LSM2 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0360068674415316 0.0369955773820136 295 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|cytoplasmic mRNA processing body|U4/U6 x U5 tri-snRNP complex
YIR001C SGN1 hom 0.0360046887480306 0.03700702304658 296 Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation mRNA metabolic process poly(A) RNA binding cytoplasm
YNL262W POL2 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0359460628541671 0.0373444976032234 297 Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p DNA replication involved in S phase|double-strand break repair via nonhomologous end joining|DNA synthesis involved in DNA repair|DNA-dependent DNA replication|mitotic cell cycle DNA replication checkpoint|mitotic sister chromatid cohesion|chromatin silencing at telomere double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity replication fork|epsilon DNA polymerase complex
YJL031C BET4 het FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN PRENYLATION 0.0357409225187472 0.0387051365639558 298 Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p protein targeting to membrane|protein geranylgeranylation|ER to Golgi vesicle-mediated transport Rab geranylgeranyltransferase activity Rab-protein geranylgeranyltransferase complex
YER068W MOT2 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.035729972992029 0.0384745829812728 299 Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|protein polyubiquitination|protein ubiquitination ubiquitin-protein ligase activity|sequence-specific DNA binding CCR4-NOT core complex|cytoplasm
YOR056C NOB1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|ENDOPLASMIC RETICULUM 0.0356734170645195 0.0387827707938881 300 Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress proteasome assembly|ribosomal small subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA endoribonuclease activity|SSU rRNA binding preribosome, small subunit precursor|nucleus|cytoplasm
YLR281C_p YLR281C hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION 0.0355424132056376 0.0395047056053466 301 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene biological_process molecular_function mitochondrion
YIL063C YRB2 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0355107704542405 0.0396807819314465 302 Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential protein export from nucleus|regulation of chromatin silencing at telomere|ribosomal small subunit export from nucleus molecular_function integral to membrane|nucleus|nuclear pore
YLR210W CLB4 hom FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS|CYTOSKELETON 0.0355014042323668 0.0397625632727563 303 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity nucleus|spindle pole body|cytoplasm
YLR305C STT4 het FT LIPID METABOLISM|SIGNALING|MITOCHONDRION|PLASMA MEMBRANE 0.0354537994910086 0.0399994757603661 304 Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization phosphatidylinositol phosphorylation 1-phosphatidylinositol 4-kinase activity mitochondrion|plasma membrane
YDL097C RPN6 het FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS 0.0353929713141058 0.0404316920551598 305 Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress proteasome assembly|ubiquitin-dependent protein catabolic process structural molecule activity proteasome storage granule|proteasome regulatory particle, lid subcomplex
YLR456W_p YLR456W hom FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM|NUCLEUS 0.0353466184681544 0.0408150855487789 306 Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YLR142W PUT1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.0353375835441502 0.0406862949664487 307 Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source glutamate biosynthetic process|proline catabolic process to glutamate proline dehydrogenase activity mitochondrion
YER021W RPN3 het FT PROTEOLYSIS 0.0353157120730066 0.0407809495157666 308 Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control ubiquitin-dependent protein catabolic process molecular_function proteasome regulatory particle, lid subcomplex
YFL017W-A SMX2 het FT RNA PROCESSING|NUCLEUS 0.0352739972525143 0.0410195537484409 309 Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G mRNA splicing, via spliceosome molecular_function U1 snRNP|U2-type prespliceosome|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YER060W FCY21 hom 0.0352692957549048 0.0410465197898357 310 Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function transmembrane transport nucleobase transmembrane transporter activity integral to membrane
YLR310C CDC25 het FT CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEUS|PLASMA MEMBRANE 0.035209224686172 0.041513832047085 311 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 regulation of cell cycle|replicative cell aging|Ras protein signal transduction|traversing start control point of mitotic cell cycle Ras guanyl-nucleotide exchange factor activity cytosol|nucleus|plasma membrane|cytoplasm
YDR152W GIR2 hom FT TRANSLATION 0.0350869267651028 0.0421962161896268 312 Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein cytoplasmic translation molecular_function polysome|cytoplasm
YNL108C_p YNL108C hom FT NUCLEUS 0.0350535546421931 0.0423001818308725 313 Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YPL190C NAB3 het FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS 0.0349437885988213 0.0429503574582068 314 RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing nuclear mRNA surveillance|mRNA 3'-end processing|antisense RNA transcript catabolic process|CUT catabolic process|termination of RNA polymerase II transcription, exosome-dependent|tRNA 3'-end processing|snRNA 3'-end processing|snoRNA 3'-end processing RNA binding|transcription regulatory region RNA binding Nrd1 complex|nucleus
YGL163C RAD54 hom FF|FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS 0.0349267520103576 0.0430520231401691 315 DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|DNA translocase activity nucleus
YMR068W AVO2 hom FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE 0.0348921422757472 0.0432591825170201 316 Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity molecular_function TORC2 complex|cytoplasm
YML078W CPR3 hom FT MITOCHONDRION 0.0348843537569518 0.0433059172002498 317 Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria protein folding|apoptotic process peptidyl-prolyl cis-trans isomerase activity mitochondrion
YNL072W RNH201 hom FT NUCLEUS 0.0347553121094914 0.0440864532231083 318 Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome DNA replication, removal of RNA primer ribonuclease H activity ribonuclease H2 complex|nucleus
YOR247W SRL1 hom FT CELL WALL ORG/BIOGENESIS|SITE OF POLARIZED GROWTH 0.0346989734789206 0.0444309337174716 319 Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication fungal-type cell wall organization|nucleobase-containing compound metabolic process molecular_function fungal-type cell wall|fungal-type vacuole|cytoplasm|cellular bud tip
YJL173C RFA3 het FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0346142880296263 0.0449530091179947 320 Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress establishment of protein localization|telomere maintenance via telomerase|telomere maintenance via recombination|nucleotide-excision repair|DNA repair|mitotic recombination|heteroduplex formation|DNA unwinding involved in replication|reciprocal meiotic recombination|double-strand break repair via homologous recombination|DNA replication|protein ubiquitination double-stranded DNA binding|sequence-specific DNA binding condensed nuclear chromosome|chromosome, telomeric region|DNA replication factor A complex
YFR032C-A RPL29 hom FT TRANSLATION|RIBOSOME 0.034587195798355 0.0451211172849279 321 Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit|cytoplasm
YMR123W PKR1 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0345571479163806 0.0461185711853158 322 V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress vacuolar proton-transporting V-type ATPase complex assembly molecular_function integral to endoplasmic reticulum membrane
YER058W PET117 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0344532404312035 0.0459601200924889 323 Protein required for assembly of cytochrome c oxidase mitochondrial respiratory chain complex IV assembly molecular_function mitochondrion
YDR381W YRA1 het FT RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|NUCLEUS 0.0344502191672981 0.0459791936241834 324 RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member mRNA export from nucleus|transcription-coupled nucleotide-excision repair RNA binding transcription export complex
YOL135C MED7 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0344014271366792 0.0462881464213464 325 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter molecular_function core mediator complex
YDL121C_p YDL121C hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0343596810556968 0.0469476306825616 326 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein biological_process molecular_function endoplasmic reticulum
YOR229W WTM2 hom FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS 0.0343472512094374 0.0466332353005309 327 Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter during meiosis|cellular protein complex localization|negative regulation of chromatin silencing at telomere|response to DNA damage stimulus|positive regulation of transcription from RNA polymerase II promoter protein binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription corepressor activity nucleus
YDR119W_p VBA4 hom 0.0342977459531129 0.0472139813709343 328 Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YHR006W STP2 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|PLASMA MEMBRANE 0.0342958247534283 0.0469628104415937 329 Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YDL195W SEC31 het FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH 0.0342706220150739 0.0471250402842486 330 Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance COPII-coated vesicle budding structural molecule activity COPII vesicle coat|mating projection tip
YDR270W CCC2 hom FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0342680782303219 0.0471414407553849 331 Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism cellular iron ion homeostasis|copper ion export|transmembrane transport copper ion binding|cation-transporting ATPase activity integral to membrane|trans-Golgi network transport vesicle membrane
YLR136C TIS11 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|NUCLEUS 0.0342311354113581 0.04738016254473 332 mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress cellular iron ion homeostasis|nuclear-transcribed mRNA catabolic process mRNA binding nucleus|cytoplasm
YGL097W SRM1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION|RNA LOCALIZATION|NUCLEUS|CHROMOSOME 0.0341098274248437 0.0482714388665717 333 Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p ribosomal subunit export from nucleus|rRNA export from nucleus signal transducer activity nuclear chromatin|integral to membrane|nucleus
YJL216C IMA5 hom FT CARBOHYDRATE METABOLISM 0.0340750555203645 0.0483999833281767 334 Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose disaccharide catabolic process oligo-1,6-glucosidase activity cellular_component
YPL237W SUI3 het FT TRANSLATION|RIBOSOME 0.0340295584029586 0.0487007061110345 335 Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding translational initiation translation initiation factor activity multi-eIF complex|ribosome|eukaryotic translation initiation factor 2 complex
YOR031W CRS5 hom 0.0338602571180576 0.0498335473660108 336 Copper-binding metallothionein, required for wild-type copper resistance response to metal ion copper ion binding cytoplasm
YJR110W YMR1 hom FT LIPID METABOLISM 0.0337319417283849 0.0507067823717924 337 Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family phosphatidylinositol dephosphorylation mRNA binding|phosphatidylinositol-3-phosphatase activity cytoplasm
YGL006W PMC1 hom FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS 0.0336560456110044 0.0513334270502251 338 Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a cellular calcium ion homeostasis|calcium ion transport|transmembrane transport calcium-transporting ATPase activity fungal-type vacuole membrane|integral to membrane
YJR048W CYC1 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0336392242664672 0.0513457033327101 339 Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c electron carrier activity mitochondrion|mitochondrial intermembrane space
YPR020W ATP20 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION 0.0336287264016457 0.0514184673713909 340 Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex protein oligomerization|cristae formation|protein complex assembly|ATP synthesis coupled proton transport structural molecule activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YMR285C NGL2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0334231766617568 0.0528960333874789 341 Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication rRNA processing endoribonuclease activity intracellular
YBL040C ERD2 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0333541403635991 0.0535306391077782 342 HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins protein retention in ER lumen|ER to Golgi vesicle-mediated transport HDEL sequence binding integral to endoplasmic reticulum membrane|integral to membrane
YCR047C BUD23 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION|NUCLEUS 0.0332936828645999 0.0537864741864398 343 Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA (guanine-N7)-methylation|cellular bud site selection|ribosomal small subunit export from nucleus S-adenosylmethionine-dependent methyltransferase activity|rRNA (guanine) methyltransferase activity nucleolus|nucleus|cytoplasm
YLR315W NKP2 hom FT CELL CYCLE|CELL DIVISION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.0331986355514982 0.0549084714423517 344 Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2 biological_process molecular_function spindle pole body|kinetochore
YKR072C SIS2 hom FF|FT CELL CYCLE|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.0331327599906479 0.0551007904492374 345 Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis regulation of mitotic cell cycle|response to salt stress|coenzyme A biosynthetic process phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity phosphopantothenoylcysteine decarboxylase complex|nucleus|cytoplasm
YHR114W BZZ1 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0330448243163336 0.055603665343245 346 SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins response to salt stress|actin filament organization|endocytosis molecular_function mating projection tip|cytoplasm|actin cortical patch
YOL122C SMF1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0329112788567394 0.0565997261250193 347 Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins copper ion transport|cellular copper ion homeostasis|manganese ion transport|cadmium ion transport|cellular manganese ion homeostasis|cellular cadmium ion homeostasis|iron ion transport solute:hydrogen symporter activity|inorganic cation transmembrane transporter activity integral to membrane|plasma membrane
YBR062C_p YBR062C hom 0.0328993053031551 0.0568374989974603 348 Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway. biological_process molecular_function cellular_component
YGR189C CRH1 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 0.0327937941664087 0.0574882274882808 349 Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress fungal-type cell wall organization|cell wall chitin metabolic process transferase activity, transferring glycosyl groups incipient cellular bud site|fungal-type cell wall
YNL228W_d YNL228W hom 0.032736877428708 0.0579228222493127 350 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Unknown Unknown Unknown
YGR083C GCD2 het FT TRANSLATION 0.032719163648457 0.058058633593704 351 Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression regulation of translational initiation enzyme regulator activity|guanyl-nucleotide exchange factor activity|translation initiation factor activity eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YLR403W SFP1 hom FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|NUCLEUS 0.0326984968452034 0.0582174199312704 352 Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of cell size|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding transcription factor activity nucleus|cytoplasm
YGR263C SAY1 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0326911559826419 0.0582739076764405 353 Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum response to toxin|sterol metabolic process|sterol deacetylation steryl deacetylase activity integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YKL059C MPE1 het FT RNA PROCESSING|NUCLEUS 0.0326745631597077 0.0584017567349935 354 Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif mRNA cleavage|mRNA polyadenylation RNA binding mRNA cleavage and polyadenylation specificity factor complex
YBR121C GRS1 het FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0326457629664275 0.058624217477803 355 Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication mitochondrial glycyl-tRNA aminoacylation|glycyl-tRNA aminoacylation|DNA-dependent transcription, termination glycine-tRNA ligase activity mitochondrion|cytoplasm
YKL188C PXA2 hom FT NUCLEOTIDE METABOLISM 0.0325148972458105 0.0596439387680101 356 Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder fatty acid transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|integral to peroxisomal membrane
YLR038C COX12 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0324924209184431 0.0598205483860342 357 Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV mitochondrial respiratory chain complex IV assembly cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YJR062C NTA1 hom FT PROTEOLYSIS|MITOCHONDRION 0.032382544834341 0.0606901600350336 358 Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation cellular protein modification process|protein catabolic process protein-N-terminal asparagine amidohydrolase activity mitochondrion
YHR138C YHR138C hom FT MEMBRANE ORGANIZATION 0.0323549891208977 0.0609098837348904 359 Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress vacuole fusion, non-autophagic endopeptidase inhibitor activity cellular_component
YBR180W DTR1 hom FT CELL WALL ORG/BIOGENESIS 0.0323140472601766 0.0612375619976502 360 Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation ascospore wall assembly|amine transport|transmembrane transport amine transmembrane transporter activity integral to membrane|prospore membrane
YLL036C PRP19 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION 0.0322145444808932 0.0620400190782553 361 Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain generation of catalytic spliceosome for first transesterification step ubiquitin-protein ligase activity|first spliceosomal transesterification activity mitochondrion|nucleus|Prp19 complex|cytoplasm|U2-type catalytic step 1 spliceosome
YDL164C CDC9 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|NUCLEUS|MITOCHONDRION|CHROMOSOME 0.0321431773086079 0.0626209118851131 362 DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination lagging strand elongation|base-excision repair|mitotic cell cycle|DNA ligation|DNA recombination|nucleotide-excision repair DNA ligase (ATP) activity mitochondrion|nucleus|replication fork
YMR058W FET3 hom FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0321014866743965 0.0629623279781778 363 Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress iron assimilation by reduction and transport|high-affinity iron ion transport|response to copper ion ferroxidase activity|iron ion transmembrane transporter activity integral to membrane|high affinity iron permease complex|plasma membrane
YAL025C MAK16 het FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0320796288599425 0.0631419413495697 364 Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus|preribosome, large subunit precursor
YML101C CUE4 hom FT ENDOPLASMIC RETICULUM 0.0320689314857037 0.0632299996054806 365 Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication biological_process molecular_function endoplasmic reticulum|cytoplasm
YJR059W PTK2 hom FF|FT CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|NUCLEUS|PLASMA MEMBRANE 0.0320314729169381 0.0635391496057479 366 Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake protein phosphorylation|cellular ion homeostasis|polyamine transport|G1/S transition of mitotic cell cycle|regulation of cell size protein kinase activity nucleus|plasma membrane|cytoplasm
YIL071C PCI8 hom FT NUCLEUS 0.0319850457346203 0.0639240498404559 367 Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain cullin deneddylation molecular_function signalosome
YGL071W AFT1 hom FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION|NUCLEUS 0.0318542309498576 0.0651390666291812 368 Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|meiotic chromosome segregation|positive regulation of iron ion transport|establishment of mitotic sister chromatid cohesion|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus|cytoplasm
YIL078W THS1 het FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION 0.0318022742982378 0.0654580468899097 369 Threonyl-tRNA synthetase, essential cytoplasmic protein cytoplasmic translation|threonyl-tRNA aminoacylation threonine-tRNA ligase activity mitochondrion|cytoplasm
YGR164W_d YGR164W hom 0.0317679209249232 0.0657497344309282 370 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR202W MCM7 het FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0317376132448965 0.0660079591844337 371 Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex S phase of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter|DNA replication initiation|DNA strand elongation involved in DNA replication|DNA unwinding involved in replication|pre-replicative complex assembly|double-strand break repair via break-induced replication|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere DNA replication origin binding|single-stranded DNA-dependent ATPase activity|transcription cofactor activity|single-stranded DNA binding|ATP-dependent 3'-5' DNA helicase activity|ATP binding|four-way junction helicase activity|DNA helicase activity|chromatin binding replication fork protection complex|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YER067W RGI1 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS|PLASMA MEMBRANE 0.0317303926096638 0.0660696028472676 372 Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress energy reserve metabolic process molecular_function cell periphery|nucleus|cytoplasm
YOL077W-A ATP19 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION 0.0315313118564861 0.0677879473851114 373 Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YOL121C RPS19A hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME 0.0314324412651479 0.0686548979457517 374 Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit biogenesis|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YML098W TAF13 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0314214419401826 0.0687519064547243 375 TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly nucleus|transcription factor TFIID complex
YMR194C-A_d YMR194C-A hom 0.03138290310609 0.0690926882727057 376 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR218C SPR28 hom FT CELL CYCLE|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0312978063366874 0.0706049796481997 377 Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation sexual sporulation resulting in formation of a cellular spore structural molecule activity spindle microtubule|meiotic spindle|septin complex|prospore membrane|ascospore wall
YPR131C NAT3 hom FT MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION 0.03122867201482 0.0704703943247707 378 Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization peptide alpha-N-acetyltransferase activity NatB complex|cytoplasm
YPL261C_d YPL261C hom 0.0311876761528241 0.0708403652436353 379 Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W Unknown Unknown Unknown
YGR264C MES1 het FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION 0.0311870386030178 0.0708461314182742 380 Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs methionyl-tRNA aminoacylation methionine-tRNA ligase activity methionyl glutamyl tRNA synthetase complex|cytoplasm
YDR196C CAB5 het FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.0311440334414509 0.0712359709190262 381 Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies coenzyme A biosynthetic process dephospho-CoA kinase activity nuclear envelope|mitochondrion|endoplasmic reticulum
YPR175W DPB2 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.031006119895432 0.0724980210813355 382 Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate DNA-dependent DNA replication double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity nucleus|epsilon DNA polymerase complex|cytoplasm
YLR034C SMF3 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0310061160319356 0.0724980566909025 383 Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress cellular iron ion homeostasis|iron ion transport metal ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YER156C_p YER156C hom FT NUCLEUS 0.0308288794098524 0.0741467582591415 384 Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1 biological_process molecular_function nucleus|cytoplasm
YPR106W ISR1 hom FT PROTEIN PHOSPHORYLATION 0.0308274353999697 0.074160315572173 385 Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C biological_process protein kinase activity cellular_component
YKR086W PRP16 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS 0.0308266401057588 0.0741677831812367 386 DEAH-box RNA helicase involved in second catalytic step of splicing; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step generation of catalytic spliceosome for second transesterification step second spliceosomal transesterification activity|RNA-dependent ATPase activity U2-type catalytic step 2 spliceosome
YDR202C RAV2 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS 0.0307226765227932 0.0751492763119135 387 Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme vacuolar acidification|regulation of protein complex assembly molecular_function RAVE complex
YOL069W NUF2 het FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.0306935736955434 0.075687683802597 388 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering microtubule nucleation|chromosome segregation structural constituent of cytoskeleton spindle microtubule|Ndc80 complex|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region|spindle pole body
YNL173C MDG1 hom FT SIGNALING|PLASMA MEMBRANE 0.0306214388715515 0.0761151964446767 389 Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations pheromone-dependent signal transduction involved in conjugation with cellular fusion molecular_function membrane raft|plasma membrane
YLL060C GTT2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION 0.0305532371600076 0.0767716059113997 390 Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress glutathione metabolic process glutathione transferase activity mitochondrion
YLR264W RPS28B hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME 0.0305354707026912 0.076943354928913 391 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YPL055C LGE1 hom FT CHROMATIN ORGANIZATION|NUCLEUS 0.0305165952683988 0.0771261672829076 392 Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division histone methylation|protein monoubiquitination|regulation of cell size|histone ubiquitination|premeiotic DNA replication molecular_function nucleus
YOR173W DCS2 hom 0.0305150205299249 0.0771414349160154 393 Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance deadenylation-dependent decapping of nuclear-transcribed mRNA m7G(5')pppN diphosphatase activity cytoplasmic mRNA processing body|cytoplasm
YLR044C PDC1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS 0.0304855665265114 0.0774274555670716 394 Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism L-phenylalanine catabolic process|pyruvate metabolic process|glucose catabolic process to ethanol|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway pyruvate decarboxylase activity cytosol|nucleus|cytoplasm
YGL013C PDR1 hom FF|FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RSC COMPLEX 0.0304716537782789 0.077562858855977 395 Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Unknown|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YOR333C_d YOR333C hom 0.0304298833865792 0.0779705402862955 396 Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth Unknown Unknown Unknown
YOL149W DCP1 het FT RNA PROCESSING 0.0304293629511931 0.0779756307444587 397 Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA mRNA binding|enzyme activator activity|m7G(5')pppN diphosphatase activity cytoplasmic mRNA processing body
YML092C PRE8 het FF|FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION 0.0303371601450542 0.0790158026731454 398 Alpha 2 subunit of the 20S proteasome proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YOR288C MPD1 hom FT ENDOPLASMIC RETICULUM 0.0302746567103867 0.0795008695102435 399 Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation protein folding protein disulfide oxidoreductase activity|protein disulfide isomerase activity fungal-type vacuole
YNL275W BOR1 hom FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT|PLASMA MEMBRANE 0.0302597470561444 0.0796491349803278 400 Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1 borate transport|protein targeting to vacuole borate efflux transmembrane transporter activity integral to membrane|plasma membrane|fungal-type vacuole
YDL094C_d YDL094C hom 0.0302566640375411 0.0796798213323585 401 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential Unknown Unknown Unknown
YMR081C ISF1 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.0302182872339509 0.0800626035427399 402 Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant aerobic respiration molecular_function cellular_component
YLR220W CCC1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0301915492245804 0.0803301785733555 403 Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress manganese ion transport|cellular calcium ion homeostasis|cellular iron ion homeostasis|cellular manganese ion homeostasis|ferrous iron transport manganese ion transmembrane transporter activity|ferrous iron transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|Golgi apparatus
YDL143W CCT4 het FF 0.0301778965561409 0.0804670845827473 404 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo protein folding unfolded protein binding chaperonin-containing T-complex
YLR343W GAS2 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PLASMA MEMBRANE 0.0301564511823504 0.0812268421117599 405 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p ascospore wall assembly 1,3-beta-glucanosyltransferase activity integral to membrane|cytoplasm
YDR531W CAB1 het FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.0301274706694413 0.0809743873082378 406 Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element coenzyme A biosynthetic process pantothenate kinase activity nucleus|cytoplasm
YER063W THO1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION|NUCLEUS 0.0300973714710502 0.0815056627169815 407 Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation poly(A)+ mRNA export from nucleus|transcription, DNA-dependent|ribonucleoprotein complex assembly chromatin binding|double-stranded DNA binding|RNA binding nucleus
YDR228C PCF11 het FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS 0.0300468650679613 0.0821101006185292 408 mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping mRNA cleavage|termination of RNA polymerase II transcription|mRNA polyadenylation mRNA binding|RNA polymerase II core binding mRNA cleavage factor complex
YGL157W ARI1 hom FT OXIDATION-REDUCTION PROCESS|NUCLEUS 0.0300232109665628 0.0820315086475152 409 NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily biological_process oxidoreductase activity|carbonyl reductase (NADPH) activity nucleus|cytoplasm
YKL043W PHD1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0300056335066468 0.0822108291854202 410 Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication pseudohyphal growth|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YER068C-A_d YER068C-A hom 0.0299949830840905 0.0824568383632921 411 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR174C CBP4 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0299381782278491 0.0829478225131901 412 Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex mitochondrial respiratory chain complex III assembly molecular_function mitochondrion|integral to mitochondrial membrane
YIL084C SDS3 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0298817239965202 0.0836683376367314 413 Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|chromatin silencing|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation histone deacetylase activity Rpd3L-Expanded complex|Rpd3L complex
YGL148W ARO2 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0298224593079666 0.0842372874727441 414 Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress aromatic amino acid family biosynthetic process chorismate synthase activity|riboflavin reductase (NADPH) activity cytoplasm
YHR096C HXT5 hom FT PLASMA MEMBRANE 0.0297761305027513 0.08458144013815 415 Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication glucose transport|hexose transport mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YOL028C YAP7 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0297612096785605 0.0847374564943649 416 Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nucleus
YLR143W DPH6 hom 0.0297603525229343 0.0847464262188883 417 Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene biological_process molecular_function cytoplasm
YKR062W TFA2 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0297423569541975 0.085167612753254 418 TFIIE small subunit, involved in RNA polymerase II transcription initiation transcription from RNA polymerase II promoter single-stranded DNA binding|RNA polymerase II core binding|TFIIH-class transcription factor binding transcription factor TFIIE complex
YNL002C RLP7 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS 0.0297340483386827 0.0851616709973635 419 Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA binding nucleolus|preribosome, large subunit precursor
YGR026W_p YGR026W hom FT PLASMA MEMBRANE 0.0296571717778262 0.0858317843508784 420 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function integral to membrane
YOL038W PRE6 het FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION 0.0296541634123342 0.0858635970104809 421 Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YBR047W_p FMP23 hom FT MITOCHONDRION 0.0296540064372566 0.0858652572412938 422 Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YLL030C_d RRT7 hom 0.0296117807174747 0.0863127956607333 423 Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL063C SYO1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.0295877823159004 0.0867559883512671 424 Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus ribosomal large subunit biogenesis molecular_function nucleus|cytoplasm
YOR334W MRS2 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION 0.0294670848300853 0.0878606874272226 425 Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns mitochondrial magnesium ion transport magnesium ion transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YGR275W RTT102 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|RSC COMPLEX 0.0294394740335748 0.0881585826775402 426 Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress chromosome segregation|nucleosome disassembly|chromatin remodeling|transcription elongation from RNA polymerase II promoter molecular_function RSC complex|SWI/SNF complex|nucleus
YPL256C CLN2 hom FT CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0294312488705594 0.0882474818615733 427 G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) regulation of cyclin-dependent protein kinase activity|re-entry into mitotic cell cycle after pheromone arrest cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YML047W-A_d YML047W-A hom 0.0294142387194677 0.0886693000632088 428 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YML036W CGI121 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|CHROMOSOME 0.0293124116917796 0.0896834766405587 429 Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification telomere maintenance|positive regulation of transcription from RNA polymerase II promoter molecular_function EKC/KEOPS complex
YHR133C NSG1 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0292377187457532 0.0903601199908323 430 Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; forms foci at the nuclear periphery upon DNA replication stress sterol biosynthetic process unfolded protein binding integral to membrane|endoplasmic reticulum
YPL136W_d YPL136W hom 0.0292202811513379 0.0905524553713544 431 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C Unknown Unknown Unknown
YNL181W_p YNL181W het FT OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0292052066608369 0.0908152879380986 432 Putative oxidoreductase; required for cell viability biological_process oxidoreductase activity|oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor nuclear envelope|endoplasmic reticulum
YAL005C SSA1 hom FT PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION|NUCLEUS 0.0291201142779361 0.091663673935034 433 ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils cytoplasmic translation|protein folding|protein refolding|protein targeting to mitochondrion|SRP-dependent cotranslational protein targeting to membrane, translocation|protein import into nucleus, translocation|response to stress unfolded protein binding|ATPase activity fungal-type vacuole membrane|fungal-type cell wall|plasma membrane|nucleus|polysome|chaperonin-containing T-complex|cytoplasm
YDL235C YPD1 het FT SIGNALING|NUCLEUS 0.0291034549864051 0.0918495446267235 434 Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus osmosensory signaling pathway via two-component system protein histidine kinase binding|transferase activity, transferring phosphorus-containing groups nucleus|cytoplasm
YDR370C DXO1 hom 0.0290942969809293 0.0919518509954933 435 Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p biological_process molecular_function cytoplasm
YGL073W HSF1 het FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION|NUCLEUS|MITOCHONDRION 0.0290493234199369 0.0924555907540791 436 Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated spindle pole body duplication|negative regulation of TOR signaling cascade|response to heat|regulation of transcription from RNA polymerase II promoter|response to stress sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity mitochondrion|nucleus
YIR006C PAN1 het FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON 0.0289828326519386 0.0932043961419961 437 Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates the Arp2/3 complex in vitro; previously thought to be a subunit of poly(A) ribonuclease bipolar cellular bud site selection|endocytosis|axial cellular bud site selection|cytokinesis|actin cortical patch assembly protein binding, bridging nucleus|plasma membrane|mating projection tip|cytoplasm|actin cortical patch
YPL071C_p YPL071C hom FT NUCLEUS 0.0288502089325647 0.0947125022202748 438 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YLR121C YPS3 hom FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS|PLASMA MEMBRANE 0.0288446024821572 0.0947766830199406 439 Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization|cellular protein metabolic process aspartic-type endopeptidase activity anchored to plasma membrane|plasma membrane
YNL006W LST8 het FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE 0.0288438156214175 0.0947856935296616 440 Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat transport|TOR signaling cascade|fungal-type cell wall organization|signal transduction|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity|mitochondria-nucleus signaling pathway protein kinase activator activity|protein binding TORC1 complex|TORC2 complex|endosome membrane|extrinsic to internal side of plasma membrane|Golgi membrane
YBL047C EDE1 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0288354265542021 0.0948818011797673 441 Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death endoplasmic reticulum unfolded protein response|endocytosis ubiquitin binding cellular bud neck|mating projection tip|actin cortical patch|cellular bud tip
YBR159W IFA38 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0288105358094569 0.0951674163131422 442 Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides fatty acid elongation ketoreductase activity integral to membrane|endoplasmic reticulum
YGR287C IMA1 hom FT CARBOHYDRATE METABOLISM|MITOCHONDRION 0.0287716458084136 0.0956150469879826 443 Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family disaccharide catabolic process oligo-1,6-glucosidase activity mitochondrion|ribosome
YDR473C PRP3 het FT RNA PROCESSING|NUCLEUS 0.0287636749815852 0.0961036764034578 444 Splicing factor, component of the U4/U6-U5 snRNP complex mRNA splicing, via spliceosome molecular_function U4/U6 x U5 tri-snRNP complex
YHR175W-A_p YHR175W-A hom 0.0286719455640447 0.0967703137186743 445 Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YAL042C-A_d YAL042C-A hom 0.0286628614515885 0.0968761273084664 446 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene Unknown Unknown Unknown
YHL042W_p YHL042W hom 0.0286377692510718 0.0971688869877673 447 Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function cellular_component
YKL027W YKL027W hom FT MITOCHONDRION 0.028611659390781 0.0975242211260605 448 Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion
YJR018W_d YJR018W hom 0.0284524757731975 0.099352718283653 449 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL013C MAD3 hom FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS 0.0284375458648783 0.0995303697099881 450 Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover distributive segregation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint molecular_function mitotic checkpoint complex
YDL214C PRR2 hom FT TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0284227909481336 0.100060457573792 451 Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation protein kinase activity|receptor signaling protein serine/threonine kinase activity nucleus
YLR211C_p YLR211C hom 0.0283888526979616 0.100111531981904 452 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron biological_process molecular_function cytoplasm
YJL057C IKS1 hom FT PROTEIN PHOSPHORYLATION 0.0283158120958076 0.100988353071608 453 Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p protein phosphorylation protein kinase activity cellular_component
YHL005C_d YHL005C hom 0.0282679387504426 0.101617358533609 454 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W Unknown Unknown Unknown
YOL066C RIB2 het FT RNA PROCESSING 0.0281573484889452 0.103065743349007 455 Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs riboflavin biosynthetic process|tRNA pseudouridine synthesis pseudouridine synthase activity|2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity cytoplasm
YLR140W_d YLR140W het 0.028044385779217 0.104300414087011 456 Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I Unknown Unknown Unknown
YOL085C_d YOL085C hom 0.0280301429730359 0.104476564572959 457 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A Unknown Unknown Unknown
YKL054C DEF1 hom FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS|CHROMOSOME 0.0280189895132742 0.105081428034059 458 RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis transcription-coupled nucleotide-excision repair|telomere maintenance|response to DNA damage stimulus|ubiquitin-dependent protein catabolic process molecular_function nucleus
YFR011C AIM13 hom FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0280126053206557 0.104693788990323 459 Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial crista junction|cytoplasm|mitochondrial intermembrane space
YBR060C ORC2 het FT CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0279677740327912 0.105614623884927 460 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p histone H3-K4 methylation|DNA replication initiation|pre-replicative complex assembly|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere chromatin binding|DNA replication origin binding DNA replication preinitiation complex|pre-replicative complex|nuclear origin of replication recognition complex
YKL068W NUP100 hom FT PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0279646427409651 0.105289692759488 461 FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; homologous to Nup116p positive regulation of transcription, DNA-dependent|mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|protein import into nucleus|protein targeting to nuclear inner membrane|mRNA export from nucleus in response to heat stress nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore
YJR076C CDC11 het FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0278633023274406 0.106766670340801 462 Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells maintenance of cell polarity|cell cycle cytokinesis|positive regulation of protein kinase activity structural molecule activity|GTP binding|1-phosphatidylinositol binding spindle microtubule|septin complex|prospore membrane|ascospore wall|mating projection base|meiotic spindle|cellular bud neck septin ring|septin filament array|cytoplasmic microtubule|mating projection tip
YKL036C_d YKL036C het 0.0278120479242578 0.107203495207955 463 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W Unknown Unknown Unknown
YLR154C RNH203 hom FT NUCLEUS 0.0277586400336344 0.10809009316967 464 Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome RNA catabolic process|DNA replication, removal of RNA primer ribonuclease H activity ribonuclease H2 complex|nucleus|cytoplasm
YOR009W TIR4 hom FT CELL WALL ORG/BIOGENESIS 0.027756588111231 0.107905843458405 465 Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock biological_process molecular_function fungal-type cell wall
YMR252C_p YMR252C hom FT MITOCHONDRION 0.0277558535967578 0.107967711037955 466 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene biological_process molecular_function mitochondrion
YNL214W PEX17 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION 0.0277361401630182 0.108165715073677 467 Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis protein import into peroxisome matrix, docking protein binding peroxisomal membrane
YOR314W_d YOR314W hom 0.0276682403067475 0.109032203135887 468 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR040W GLO4 hom FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|MITOCHONDRION 0.0276330348704834 0.109483624167739 469 Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate hydroxyacylglutathione hydrolase activity mitochondrion|mitochondrial matrix
YLR440C SEC39 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0275947847921324 0.109975757682158 470 Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope retrograde vesicle-mediated transport, Golgi to ER|vesicle-mediated transport|ER-dependent peroxisome organization molecular_function Dsl1p complex|nuclear envelope|endoplasmic reticulum|peroxisome|endoplasmic reticulum membrane
YGL144C ROG1 hom FT LIPID METABOLISM 0.0274881583456749 0.111356863075192 471 Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication cellular lipid metabolic process lipase activity cellular_component
YKR011C YKR011C hom FT NUCLEUS 0.0274168656125122 0.112287907071372 472 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YPL130W SPO19 hom FT CELL CYCLE|MEMBRANE ORGANIZATION 0.0274006461907593 0.112500578160548 473 Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation meiosis|spore membrane bending pathway molecular_function fungal-type cell wall|prospore membrane
YKR034W DAL80 hom FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.027399476776147 0.112515923930989 474 Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YPR006C ICL2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION 0.0273713730218196 0.113046365846653 475 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol threonine catabolic process|propionate metabolic process methylisocitrate lyase activity mitochondrion|mitochondrial matrix
YGL132W_d YGL132W hom 0.0273478004025035 0.11319570127927 476 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C Unknown Unknown Unknown
YAL065C_p YAL065C hom 0.0273350881746279 0.11336341910544 477 Putative protein of unknown function; has homology to FLO1; possible pseudogene biological_process molecular_function cellular_component
YER155C BEM2 hom FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0272820800079376 0.11406488843621 478 Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence negative regulation of Rho protein signal transduction|fungal-type cell wall organization|establishment of cell polarity|actin cytoskeleton organization Rho GTPase activator activity cell cortex|incipient cellular bud site|mitochondrion|plasma membrane|mating projection tip|cytoplasm|cellular bud tip
YMR241W YHM2 hom FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION 0.0272612420718726 0.11434157517897 479 Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome tricarboxylic acid transport|mitochondrial citrate transport|alpha-ketoglutarate transport|mitochondrial genome maintenance tricarboxylate secondary active transmembrane transporter activity|DNA binding mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YLR272C YCS4 het FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0272306696091602 0.114748472578867 480 Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation maintenance of rDNA|meiotic chromosome condensation|mitotic chromosome condensation|tRNA gene clustering|mitotic sister chromatid segregation|chromatin silencing at silent mating-type cassette molecular_function nucleolus|nuclear condensin complex
YKL047W_p ANR2 hom 0.0272188551382027 0.114906019383951 481 Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YPR068C HOS1 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS 0.02720926239972 0.115034064307345 482 Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex peptidyl-lysine deacetylation|histone H4 deacetylation|positive regulation of transcription from RNA polymerase II promoter histone deacetylase activity|protein deacetylase activity histone deacetylase complex
YKL029C MAE1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.0270917073684192 0.116885187994014 483 Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids pyruvate metabolic process|cellular amino acid metabolic process malic enzyme activity mitochondrion
YML068W ITT1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION 0.0270386242884384 0.117330557719582 484 Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins regulation of translational termination molecular_function cellular_component
YOL133W HRT1 het FT CELL CYCLE|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0269946113157795 0.11792869380362 485 RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF G2/M transition of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle ubiquitin-protein ligase activity SCF ubiquitin ligase complex|nucleus|cytoplasm
YOR151C RPB2 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION|RNA POL II, HOLOENZYME 0.0269559129813873 0.118456577167708 486 RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity mitochondrion|DNA-directed RNA polymerase II, core complex
YDL172C_d YDL172C hom 0.0268611092030307 0.119757620998171 487 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL200W CSM4 hom FT CELL CYCLE|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|CHROMOSOME 0.0268435642949147 0.119999621570215 488 Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements meiotic telomere clustering|meiotic chromosome segregation|synapsis|regulation of reciprocal meiotic recombination molecular_function nuclear chromosome, telomeric region|endoplasmic reticulum membrane
YPL151C PRP46 het FT CELL CYCLE|RNA PROCESSING|NUCLEUS 0.0268047137614093 0.120592213144089 489 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs mRNA splicing, via spliceosome molecular_function Prp19 complex|spliceosomal complex
YCR004C YCP4 hom FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.0267833783420627 0.120832688662337 490 Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process electron carrier activity mitochondrion|membrane raft|plasma membrane|cytoplasm
YDL229W SSB1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS 0.0267496588835014 0.121301391597388 491 Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication cytoplasmic translation|cellular response to glucose starvation|translational termination|ribosomal subunit export from nucleus|regulation of translational fidelity|rRNA processing|'de novo' cotranslational protein folding unfolded protein binding|ATPase activity|calmodulin binding plasma membrane|polysome|cytoplasm
YJL089W SIP4 hom FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.0266045592689952 0.12333452355601 492 C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YMR155W_p YMR155W hom 0.0265907972284277 0.123528729583433 493 Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen biological_process molecular_function integral to membrane
YLR228C ECM22 hom FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|NUCLEUS 0.0265886945355963 0.123726455120817 494 Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|membrane|perinuclear region of cytoplasm
YOL097C WRS1 het FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION 0.0265644192319371 0.123901635333967 495 Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA tryptophanyl-tRNA aminoacylation tryptophan-tRNA ligase activity cytoplasm
YOR340C RPA43 het FF|FT NUCLEUS 0.0265306386223495 0.124380473478279 496 RNA polymerase I subunit A43 transcription of nuclear large rRNA transcript from RNA polymerase I promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase I complex
YFL044C OTU1 hom FT PROTEOLYSIS|NUCLEUS 0.0265061882495795 0.124784175675482 497 Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress protein deubiquitination|regulation of transcription, DNA-dependent ubiquitin-specific protease activity nucleus|cytoplasm
YOL006C TOP1 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0264489052312111 0.125545008322043 498 Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination nuclear migration|chromatin assembly or disassembly|DNA topological change|DNA strand elongation involved in DNA replication|regulation of mitotic recombination|chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|mitotic chromosome condensation|transcription elongation from RNA polymerase II promoter DNA topoisomerase type I activity replication fork protection complex|nucleolus|nucleus
YER163C GCG1 hom FT NUCLEUS 0.0264337745771486 0.12604394208449 499 Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle biological_process molecular_function nucleus|cytoplasm
YHL014C YLF2 hom FT MITOCHONDRION 0.0264080571250168 0.126130184899739 500 Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process GTP binding mitochondrion
YPR119W CLB2 hom FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0263956324912561 0.126308596657162 501 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity nucleus|spindle pole body|cellular bud neck|spindle|cytoplasm
YPR048W TAH18 het FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM|MITOCHONDRION 0.0262779369948435 0.128008405318114 502 Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance oxidation-reduction process|iron-sulfur cluster assembly oxidoreductase activity, acting on NADH or NADPH mitochondrion
YMR007W_d YMR007W hom 0.0262734505406014 0.128073550672172 503 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL096C RPS7B hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS|RIBOSOME 0.0262631242384338 0.128223591170906 504 Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|ribosome biogenesis structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit
YMR157C AIM36 hom FT MITOCHONDRION 0.0262581870246937 0.128295376813311 505 Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YPL087W YDC1 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.0262014930797135 0.129121929924242 506 Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication ceramide catabolic process|ceramide biosynthetic process dihydroceramidase activity integral to membrane|endoplasmic reticulum
YNL336W COS1 hom 0.0261937027200718 0.129235829622898 507 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function integral to membrane|fungal-type vacuole
YGR176W_d YGR176W hom 0.0261652925180298 0.129766281379576 508 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCR054C CTR86 het FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0261213105797707 0.1303552981503 509 Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function cytoplasm
YCR010C ADY2 hom FT CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION|PLASMA MEMBRANE 0.0261194024043666 0.130383391934899 510 Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication nitrogen utilization|ammonium transport|acetate transport|transmembrane transport acetate transmembrane transporter activity|ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YBR001C NTH2 hom FF|FT CARBOHYDRATE METABOLISM|MITOCHONDRION 0.0261193651424165 0.130326616277862 511 Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication trehalose catabolic process alpha,alpha-trehalase activity mitochondrion|cytoplasm
YKL060C FBA1 het FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0261110152479027 0.130449582567487 512 Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress gluconeogenesis|glycolysis fructose-bisphosphate aldolase activity cytosol|mitochondrion|cytoplasm
YDL217C TIM22 het FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0260746776286941 0.130985763433874 513 Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported protein import into mitochondrial inner membrane mitochondrion targeting sequence binding|protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YGR147C NAT2 het FT MITOCHONDRION 0.0260626443492051 0.131163696897824 514 Protein with an apparent role in acetylation of N-terminal methionine residues N-terminal peptidyl-methionine acetylation molecular_function mitochondrion
YFR003C YPI1 het FT CELL CYCLE|LIPID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS 0.0260255125362788 0.131713937925869 515 Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance negative regulation of phosphoprotein phosphatase activity|glycogen metabolic process|cellular ion homeostasis|Unknown|positive regulation of phosphoprotein phosphatase activity|negative regulation of protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint protein serine/threonine phosphatase inhibitor activity|protein phosphatase type 1 activator activity nucleus
YPR082C DIB1 het FT CELL CYCLE|RNA PROCESSING|CELL DIVISION|NUCLEUS 0.0259683277162195 0.132564831535699 516 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein mRNA splicing, via spliceosome molecular_function U4/U6 x U5 tri-snRNP complex|U5 snRNP
YFR043C IRC6 hom 0.025953528433776 0.132785732203342 517 Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YIL037C PRM2 hom 0.0258776744698784 0.133922437138142 518 Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion karyogamy involved in conjugation with cellular fusion molecular_function integral to membrane
YBL049W MOH1 hom 0.0258554196704667 0.134257358540808 519 Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase biological_process molecular_function cellular_component
YER113C TMN3 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0258398685946199 0.134491776915434 520 Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|invasive growth in response to glucose limitation molecular_function COPI-coated vesicle|integral to membrane|Golgi apparatus
YML111W BUL2 hom FT UBIQUITIN LIGASE COMPLEX 0.0258174270307123 0.13483062056782 521 Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication protein polyubiquitination|protein monoubiquitination ubiquitin-ubiquitin ligase activity ubiquitin ligase complex|cytoplasm
YLR341W SPO77 hom FT CELL WALL ORG/BIOGENESIS 0.0257427747798729 0.135962537071801 522 Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis ascospore wall assembly|ascospore formation molecular_function intracellular
YOL097W-A_p YOL097W-A hom 0.0257325328072429 0.136118401659015 523 Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YLR322W_d VPS65 hom 0.0256756521609989 0.138281473265482 524 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth Unknown Unknown Unknown
YLR084C RAX2 hom FT CELL CYCLE|CELL DIVISION|MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0256493888673159 0.137447449635875 525 N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p cellular bud site selection molecular_function mitochondrion|cellular bud scar|cellular bud neck|membrane
YDR037W KRS1 het FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION 0.0256453025888129 0.137451483655957 526 Lysyl-tRNA synthetase lysyl-tRNA aminoacylation lysine-tRNA ligase activity cytoplasm
YBR228W SLX1 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0255959874678579 0.138386012891421 527 Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p DNA-dependent DNA replication 5'-flap endonuclease activity Slx1-Slx4 complex|nucleus
YOR232W MGE1 het FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0255869941184905 0.138524682787514 528 Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE protein refolding|protein import into mitochondrial matrix adenyl-nucleotide exchange factor activity mitochondrion|presequence translocase-associated import motor|mitochondrial matrix
YBR157C ICS2 hom 0.0254561938713087 0.14037604040986 529 Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization biological_process molecular_function cellular_component
YER145C FTR1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0253530462507866 0.14199125116275 530 High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress iron assimilation by reduction and transport|high-affinity iron ion transport|transmembrane transport iron ion transmembrane transporter activity high affinity iron permease complex|integral to membrane|plasma membrane
YFR001W LOC1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION|NUCLEUS 0.0253286691706186 0.14237505351667 531 Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; relocalizes from nucleus to cytoplasm upon DNA replication stress endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|intracellular mRNA localization mRNA binding nucleolus|preribosome, large subunit precursor
YOR290C SNF2 hom FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|RSC COMPLEX 0.0253221366685892 0.142478038945999 532 Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p cellular alcohol catabolic process|ATP-dependent chromatin remodeling|double-strand break repair|strand invasion|positive regulation of mating type switching|sucrose catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|nucleosome mobilization|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter histone acetyl-lysine binding|RNA polymerase II activating transcription factor binding|DNA-dependent ATPase activity|nucleosomal DNA binding SWI/SNF complex|nucleus
YAR023C_p YAR023C hom 0.0253112812748226 0.142649301530175 533 Putative integral membrane protein, member of DUP240 gene family biological_process molecular_function cellular_component
YGL231C EMC4 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0252439810902017 0.143714605368076 534 Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YGR269W_d YGR269W hom 0.0251481662473204 0.145241779528204 535 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C Unknown Unknown Unknown
YER087C-B SBH1 hom FT PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0251399443577953 0.145373403207057 536 Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p posttranslational protein targeting to membrane, translocation|SRP-dependent cotranslational protein targeting to membrane, translocation ARF guanyl-nucleotide exchange factor activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity Sec61 translocon complex
YIL101C XBP1 hom FT NUCLEUS 0.0251298675840503 0.145534846105844 537 Transcriptional repressor; binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress response to stress sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YDL022W GPD1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.0251065694767831 0.146149250608831 538 NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity NADH oxidation|intracellular accumulation of glycerol glycerol-3-phosphate dehydrogenase [NAD+] activity cytosol|peroxisome|nucleus
YMR226C YMR226C hom FT OXIDATION-REDUCTION PROCESS|NUCLEUS 0.0250999662069991 0.146014712414346 539 NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments metabolic process oxidoreductase activity|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|carbonyl reductase (NADPH) activity integral to membrane|ribosome|nucleus|cytoplasm
YNR038W DBP6 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0250875864743673 0.146213740043701 540 Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ATP-dependent RNA helicase activity nucleolus|preribosome, large subunit precursor
YHR193C EGD2 hom FT PROTEIN LOCALIZATION|NUCLEUS 0.0250827456627255 0.146351796648978 541 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes 'de novo' cotranslational protein folding unfolded protein binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding nascent polypeptide-associated complex
YLR412W BER1 hom FT CYTOSKELETON 0.025062798324345 0.146612880092744 542 Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene biological_process molecular_function cytoplasm
YPR004C AIM45 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0249787650039328 0.14797218976865 543 Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response biological_process molecular_function mitochondrion
YOR352W TFB6 hom FT NUCLEUS 0.02497122620531 0.148094605094514 544 Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus biological_process molecular_function nucleus|holo TFIIH complex|cytoplasm
YJR051W OSM1 hom FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.0249684575832779 0.148200059798617 545 Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication cellular response to anoxia fumarate reductase (NADH) activity mitochondrion
YNR059W MNT4 hom FT CARBOHYDRATE METABOLISM 0.0249588654290477 0.148355990865894 546 Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation protein O-linked glycosylation alpha-1,3-mannosyltransferase activity cellular_component
YDR067C_p OCA6 hom 0.0249256832833731 0.148835778318417 547 Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT biological_process molecular_function cytoplasm
YBR177C EHT1 hom FT KETONE METABOLISM|LIPID METABOLISM|MITOCHONDRION 0.0248991709489555 0.149268546237584 548 Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process|cellular lipid metabolic process short-chain carboxylesterase activity|alcohol O-butanoyltransferase activity|serine hydrolase activity mitochondrial outer membrane|mitochondrion|lipid particle
YPL193W RSA1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.0248962093854693 0.149316948172246 549 Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly ribosomal large subunit assembly molecular_function nucleoplasm
YDR251W PAM1 hom FT OXIDATION-REDUCTION PROCESS|SITE OF POLARIZED GROWTH 0.0248839965543784 0.149516673508066 550 Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype pseudohyphal growth molecular_function cellular bud|cellular bud neck
YLR180W SAM1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM 0.0248452654776367 0.150151418839239 551 S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication methionine metabolic process|S-adenosylmethionine biosynthetic process methionine adenosyltransferase activity cytoplasm
YIR043C YIR043C hom 0.0248443624421155 0.150166242728167 552 Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family biological_process molecular_function cellular_component
YBL039W-B_p YBL039W-B hom 0.0248394803837544 0.15024640406713 553 Putative protein of unknown function biological_process molecular_function cellular_component
YIL077C_p YIL077C hom FT MITOCHONDRION 0.0248218627411528 0.15053594955786 554 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) biological_process molecular_function mitochondrion
YJR024C MDE1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0247997111545193 0.150900613474521 555 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant L-methionine salvage from methylthioadenosine methylthioribulose 1-phosphate dehydratase activity cytoplasm
YBL030C PET9 het FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0247638160422893 0.151676083687793 556 Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication heme transport|transmembrane transport|aerobic respiration|anaerobic respiration|ATP transport|ADP transport|apoptotic process|mitochondrial transport ATP:ADP antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YKL109W HAP4 hom FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS 0.0247484886860735 0.151746424820231 557 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex regulation of cellular respiration|carbon catabolite activation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity CCAAT-binding factor complex
YLR390W-A CCW14 hom FT CELL WALL ORG/BIOGENESIS|MITOCHONDRION 0.0247173397493601 0.152507245072043 558 Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall fungal-type cell wall organization structural constituent of cell wall mitochondrion|fungal-type cell wall
YLR222C UTP13 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0247130728282723 0.152333336263639 559 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) snoRNA binding small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YLR393W ATP10 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0247095914793852 0.152391122262169 560 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6 mitochondrial proton-transporting ATP synthase complex assembly unfolded protein binding integral to mitochondrial membrane|mitochondrion|mitochondrial inner membrane
YGR192C TDH3 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.024654523759647 0.153307396525818 561 Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YDR024W_d FYV1 hom 0.0246368306564696 0.153848224857155 562 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin Unknown Unknown Unknown
YPR110C RPC40 het FT NUCLEUS 0.0246198794955831 0.153885986436017 563 RNA polymerase subunit AC40, common to RNA polymerase I and III tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex
YHR136C SPL2 hom 0.0245477020188956 0.155096741134414 564 Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm response to temperature stimulus enzyme inhibitor activity cytoplasm
YOR324C FRT1 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0245292678912811 0.155407123930424 565 Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication response to stress molecular_function endoplasmic reticulum
YDR025W RPS11A hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0245269757804113 0.155754161174832 566 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YIR010W DSN1 het FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.0245238594657083 0.155498277125258 567 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation chromosome segregation molecular_function nuclear MIS12/MIND type complex|kinetochore|spindle pole
YPR046W MCM16 hom FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE 0.0245037164213298 0.155838123372789 568 Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome kinetochore
YLL054C_p YLL054C hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0245034771198158 0.155842164165913 569 Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene biological_process sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity cellular_component
YHR080C YHR080C hom FT MITOCHONDRION 0.0245027487466255 0.155916152431112 570 Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication biological_process molecular_function mitochondrion|ribosome
YER133W GLC7 het FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CELL DIVISION|CARBOHYDRATE METABOLISM 0.0244764648058282 0.156484149321278 571 Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest replication fork processing|glycogen metabolic process|chromosome segregation|regulation of cell shape during vegetative growth phase|termination of RNA polymerase II transcription, poly(A)-coupled|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|rRNA processing|regulation of cell cycle|ascospore formation|protein localization to kinetochore|cell budding|DNA damage checkpoint|meiosis|termination of RNA polymerase II transcription, exosome-dependent|DNA replication checkpoint|response to heat|cellular ion homeostasis|histone dephosphorylation|regulation of carbohydrate metabolic process protein serine/threonine phosphatase activity protein phosphatase type 1 complex|mating projection base|condensed nuclear chromosome kinetochore|mRNA cleavage and polyadenylation specificity factor complex|nucleolus|spindle pole body|cellular bud neck
YPL192C PRM3 hom FT MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON 0.0244622223691178 0.156539971362983 572 Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body karyogamy involved in conjugation with cellular fusion|nuclear membrane fusion involved in karyogamy molecular_function nuclear envelope|spindle pole body|extrinsic to nuclear outer membrane
YKL062W MSN4 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS 0.0244162235685681 0.15732081209009 573 Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cellular response to acidity|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|replicative cell aging|age-dependent response to oxidative stress involved in chronological cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YBR168W PEX32 hom FT PEROXISOME ORGANIZATION 0.0244018511937995 0.158372842005868 574 Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p peroxisome organization molecular_function integral to membrane|integral to peroxisomal membrane
YJL020C BBC1 hom FT CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.0243950784130191 0.157928759968559 575 Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches actin cytoskeleton organization myosin I binding actin cortical patch
YKR082W NUP133 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0243327494815159 0.158745334879215 576 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133 poly(A)+ mRNA export from nucleus|double-strand break repair|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|tRNA export from nucleus|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore outer ring
YJL098W SAP185 hom FT CELL CYCLE|RNA PROCESSING|MITOCHONDRION 0.0243245453715957 0.158885866720045 577 Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication tRNA wobble uridine modification|G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity mitochondrion|cytoplasm
YHR121W LSM12 hom FT NUCLEUS 0.0242375666763409 0.160381556298422 578 Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress RNA metabolic process RNA binding ribosome|nucleus|cytoplasmic stress granule|cytoplasm
YOR258W HNT3 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.0242339245102302 0.160444418404692 579 DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress response to DNA damage stimulus DNA 5'-adenosine monophosphate hydrolase activity nucleus|cytoplasm
YDL026W_d YDL026W hom 0.0241667583571921 0.161794700955772 580 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR311W TFB1 het FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME 0.0240556345977209 0.163544428047568 581 Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators phosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase I promoter|nucleotide-excision repair|transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YOL040C RPS15 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME 0.0239912689915021 0.164674600769686 582 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YCR102C_p YCR102C hom FT OXIDATION-REDUCTION PROCESS 0.0239880478634588 0.165488827927539 583 Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family response to copper ion molecular_function cellular_component
YKL017C HCS1 hom FT NUCLEUS|CHROMOSOME 0.0238400992504704 0.167352038941814 584 Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities lagging strand elongation ATP-dependent 5'-3' DNA helicase activity DNA helicase A complex|alpha DNA polymerase:primase complex
YPR145W ASN1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0237968580549493 0.168123884478785 585 Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication asparagine biosynthetic process asparagine synthase (glutamine-hydrolyzing) activity cytoplasm
YNL217W_p YNL217W hom 0.0237648001586539 0.168697832867291 586 Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate biological_process phosphatase activity fungal-type vacuole
YDR145W TAF12 het FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE 0.0237628934973783 0.168732015014847 587 Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter TBP-class protein binding|chromatin binding|RNA polymerase II activating transcription factor binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YMR029C FAR8 hom FT CELL CYCLE|SIGNALING|ENDOPLASMIC RETICULUM 0.0237613936833727 0.168758906956284 588 Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p re-entry into mitotic cell cycle after pheromone arrest molecular_function cellular_component
YNR036C MRPS12 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0237509494515916 0.169327957293021 589 Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins mitochondrial translation structural constituent of ribosome mitochondrion|ribosome|mitochondrial small ribosomal subunit
YPL014W_p YPL014W hom FT NUCLEUS 0.0237454313702218 0.169045313364597 590 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus biological_process molecular_function nucleus|cytoplasm
YLR359W ADE13 het FT NUCLEOTIDE METABOLISM 0.0236866928601412 0.170102377309551 591 Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity cellular_component
YLR436C ECM30 hom FT CELL WALL ORG/BIOGENESIS 0.023667840703828 0.170442690087312 592 Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm fungal-type cell wall organization molecular_function cytoplasm
YBR181C RPS6B hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0235898608736939 0.171855773684966 593 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|cytoplasm
YNL325C FIG4 hom FT LIPID METABOLISM 0.023553613683394 0.172515589870962 594 Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity fungal-type vacuole membrane|PAS complex|extrinsic to membrane
YDR074W TPS2 hom FT CARBOHYDRATE METABOLISM|MITOCHONDRION 0.023549561633287 0.172653490855966 595 Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress trehalose biosynthetic process|response to stress trehalose-phosphatase activity mitochondrion|alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YBL071W-A KTI11 hom FT RNA PROCESSING|NUCLEUS 0.0235326556685375 0.173026109019942 596 Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs peptidyl-diphthamide biosynthetic process from peptidyl-histidine|tRNA wobble uridine modification electron carrier activity|iron ion binding|zinc ion binding nucleus|cytoplasm
YFL040W_p YFL040W hom 0.0235285144823746 0.1740665353225 597 Putative transporter, member of the sugar porter family; YFL040W is not an essential gene transmembrane transport substrate-specific transmembrane transporter activity integral to membrane|membrane
YLR090W XDJ1 hom FT NUCLEUS|MITOCHONDRION 0.0235098252413225 0.173315204877802 598 Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies protein folding chaperone binding mitochondrion|integral to mitochondrial outer membrane|nucleus
YLR375W STP3 hom FT NUCLEUS 0.0234932343245366 0.173618891625658 599 Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids biological_process sequence-specific DNA binding nucleus
YOR224C RPB8 het FF|FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0234814054837048 0.174221154605175 600 RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YIL129C TAO3 het FT CELL DIVISION|MITOCHONDRION|SITE OF POLARIZED GROWTH 0.023434251629253 0.174701752563645 601 Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p cell morphogenesis|cell budding|budding cell apical bud growth molecular_function incipient cellular bud site|mitochondrion|cellular bud|mating projection tip
YCR037C PHO87 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS 0.0234322230096172 0.174739085350555 602 Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication phosphate ion transport|transmembrane transport inorganic phosphate transmembrane transporter activity integral to membrane|membrane
YPR195C_d YPR195C hom 0.0234244810841928 0.174881615092457 603 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YML052W SUR7 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|MITOCHONDRION|PLASMA MEMBRANE 0.0233839293805349 0.175629593872251 604 Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants endocytosis|ascospore formation molecular_function cell cortex|eisosome|mitochondrion|membrane raft|integral to membrane|plasma membrane|actin cortical patch
YLR120C YPS1 hom FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS|PLASMA MEMBRANE 0.023371870551778 0.175852479185614 605 Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization|protein processing aspartic-type endopeptidase activity fungal-type cell wall
YOR132W VPS17 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM 0.0233430343770705 0.176386317772479 606 Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes retrograde transport, endosome to Golgi protein transporter activity|phosphatidylinositol-3-phosphate binding endosome|retromer complex, outer shell|retromer complex
YJL010C NOP9 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.023334990107204 0.176535454984313 607 Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit export from nucleus RNA binding preribosome, small subunit precursor|nucleolus|nucleus|90S preribosome
YHR007C-A_p YHR007C-A hom 0.0233269173313222 0.176685215104814 608 Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YJR040W GEF1 hom FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE 0.0233230789365679 0.176756455329491 609 Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism cellular copper ion homeostasis|cellular iron ion homeostasis voltage-gated chloride channel activity endosome|integral to membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|fungal-type vacuole|Golgi medial cisterna
YOR050C_d YOR050C hom 0.0233073868158462 0.177047922060784 610 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable Unknown Unknown Unknown
YJR093C FIP1 het FT RNA PROCESSING|NUCLEUS 0.023284423040118 0.177475097977584 611 Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p mRNA cleavage|mRNA polyadenylation RNA binding|protein binding, bridging mRNA cleavage and polyadenylation specificity factor complex
YMR300C ADE4 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM 0.0232502022278438 0.178501781483106 612 Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway 'de novo' IMP biosynthetic process amidophosphoribosyltransferase activity cytoplasm
YDR008C_d YDR008C hom FF 0.0232350163648573 0.17930569324021 613 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL094C LYS12 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.0231935235252049 0.179173556027913 614 Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate lysine biosynthetic process homoisocitrate dehydrogenase activity mitochondrion
YHR162W MPC2 hom 0.0231468502455092 0.180245241894764 615 Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium mitochondrial pyruvate transport pyruvate transmembrane transporter activity mitochondrion|integral to mitochondrial inner membrane
YNL207W RIO2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0231417055889538 0.180147165457368 616 Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleocytoplasmic transporter activity|protein kinase activity cytosol|nucleus|cytoplasm
YMR082C_d YMR082C hom 0.0231399187068422 0.180505880447594 617 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLL016W SDC25 hom FT SIGNALING 0.02308798920779 0.181160586656572 618 Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication Ras protein signal transduction Ras guanyl-nucleotide exchange factor activity cellular_component
YMR294W JNM1 hom FF|FT CELL CYCLE|CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.0230807311756027 0.181297841520514 619 Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B nuclear migration|establishment of mitotic spindle orientation structural constituent of cytoskeleton dynactin complex|cell cortex|spindle pole body|astral microtubule
YBL089W AVT5 hom 0.0230696940760642 0.181506709239928 620 Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication transport transporter activity integral to membrane
YBR040W FIG1 hom FT SITE OF POLARIZED GROWTH 0.023008395973165 0.182669973008927 621 Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating cell morphogenesis involved in conjugation with cellular fusion|cytogamy molecular_function fungal-type cell wall|integral to membrane|mating projection tip
YMR158W-B_d YMR158W-B hom 0.0229435978906499 0.183905653383015 622 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C Unknown Unknown Unknown
YGR146C-A_p YGR146C-A hom 0.0229202815950505 0.184351798700153 623 Putative protein of unknown function biological_process molecular_function cellular_component
YDR409W SIZ1 hom FT CHROMOSOME SEGREGATION|NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON 0.0229175483096228 0.184404151108223 624 SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring protein sumoylation|chromosome segregation SUMO ligase activity nuclear chromatin|septin ring
YOL100W PKH2 hom FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0228922777883159 0.184888695056419 625 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p regulation of nuclear-transcribed mRNA poly(A) tail shortening|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly protein kinase activity cell cortex|eisosome|nucleus
YGR260W TNA1 hom FT MITOCHONDRION|PLASMA MEMBRANE 0.0228918420151527 0.184897058942392 626 High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) nicotinamide mononucleotide transport nicotinamide mononucleotide transmembrane transporter activity mitochondrion|integral to membrane|integral to plasma membrane
YOL029C_p YOL029C hom 0.0228858912228773 0.185011301753202 627 Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens biological_process molecular_function cellular_component
YHL025W SNF6 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|NUCLEUS|RSC COMPLEX 0.0227886183926441 0.186886144144574 628 Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions sucrose catabolic process|nucleotide-excision repair|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex|nucleus
YKR051W_p YKR051W hom 0.0227733518035475 0.187181662315208 629 Putative protein of unknown function biological_process molecular_function integral to membrane
YOR022C_p YOR022C hom FT LIPID METABOLISM|MITOCHONDRION 0.0227209047439267 0.188199517491395 630 Putative carboxylic ester hydrolase; similar to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process phospholipase activity mitochondrion
YBL052C SAS3 hom FT CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.0226854859027304 0.189087130402465 631 Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal histone acetylation|chromatin modification|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette histone acetyltransferase activity NuA3 histone acetyltransferase complex
YGL162W SUT1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0226839327264064 0.188919493068175 632 Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding nucleus
YIL057C RGI2 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.0226622315782124 0.189343035288817 633 Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose energy reserve metabolic process molecular_function cytoplasm
YPR201W ARR3 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0226484303734329 0.189612757653923 634 Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite arsenite transport|antimonite transport antiporter activity|arsenite transmembrane transporter activity|antimonite transmembrane transporter activity integral to membrane|plasma membrane
YGR037C ACB1 hom FF|FT KETONE METABOLISM|LIPID METABOLISM|NUCLEUS 0.0224964909029603 0.192600898490882 635 Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress long-chain fatty acid transport|chronological cell aging|fatty acid metabolic process long-chain fatty acid transporter activity|fatty-acyl-CoA binding extracellular region|nucleus|cytoplasm
YBR167C POP7 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0224635857609004 0.193252565288559 636 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing ribonuclease MRP activity|ribonuclease P activity nucleolar ribonuclease P complex|ribonuclease MRP complex
YOR381W FRE3 hom FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|PLASMA MEMBRANE 0.0224548223532396 0.193426392048697 637 Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels cellular iron ion homeostasis|siderophore transport ferric-chelate reductase activity integral to membrane|plasma membrane
YBR067C TIP1 hom FT CELL WALL ORG/BIOGENESIS 0.0224503250682663 0.193515642595055 638 Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins fungal-type cell wall organization structural constituent of cell wall|lipase activity fungal-type cell wall
YBL008W HIR1 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.0224266807786216 0.194318060606512 639 Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter nucleosome binding|transcription corepressor activity|DNA binding chromosome, centromeric region|HIR complex|nucleus
YBL034C STU1 het FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|CHROMOSOME|CYTOSKELETON 0.0224258858223087 0.194001178431109 640 Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles microtubule nucleation structural constituent of cytoskeleton spindle pole body
YNL201C PSY2 hom FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0224222318276355 0.194140342963625 641 Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3 Unknown|response to DNA damage stimulus|protein dephosphorylation|signal transduction involved in meiotic recombination checkpoint protein serine/threonine phosphatase activity condensed nuclear chromosome|nucleus
YEL028W_d YEL028W hom 0.0224064149502148 0.194455172440319 642 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCR060W TAH1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEUS 0.0223919323637751 0.194677216369495 643 Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II protein folding|box C/D snoRNP assembly chaperone binding R2TP complex|nucleus|cytoplasm
YGR186W TFG1 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0223793657656286 0.194927863945591 644 TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74 transcription initiation from RNA polymerase II promoter|transcriptional start site selection at RNA polymerase II promoter|dephosphorylation of RNA polymerase II C-terminal domain|promoter clearance from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|regulation of protein serine/threonine phosphatase activity core RNA polymerase II binding transcription factor activity|protein phosphatase activator activity|core RNA polymerase II recruiting transcription factor activity transcription factor TFIIF complex
YBR034C HMT1 hom FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION|NUCLEUS 0.0223502150389427 0.195510201719247 645 Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region. mRNA export from nucleus|negative regulation of DNA-dependent transcription, termination|positive regulation of transcription elongation from RNA polymerase II promoter|peptidyl-arginine methylation protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity nucleus
YOR298W MUM3 hom FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS 0.0223454314536788 0.195672533127598 646 Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases ascospore wall assembly|phospholipid biosynthetic process transferase activity, transferring acyl groups cellular_component
YNL082W PMS1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS 0.0223252091651929 0.196010753618673 647 ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL mismatch repair|meiotic mismatch repair double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding nucleus|MutLalpha complex|cytoplasm
YIR023W DAL81 hom FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.0222982730798081 0.196550992732029 648 Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process|urea catabolic process RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YJL088W ARG3 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0222955908464412 0.196604848120532 649 Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine arginine biosynthetic process|ornithine metabolic process ornithine carbamoyltransferase activity cytosol
YCR100C_p YCR100C hom 0.022274328480204 0.197032148138309 650 Putative protein of unknown function biological_process molecular_function integral to membrane
YMR158C-A_p YMR158C-A hom 0.0222535914573088 0.197449544827659 651 Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene biological_process molecular_function cellular_component
YHR076W PTC7 hom FT ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION 0.0222149149310597 0.198229757056001 652 Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope biological_process protein serine/threonine phosphatase activity nuclear envelope|mitochondrion
YBR110W ALG1 het FT LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.022152883606251 0.199485802161389 653 Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog oligosaccharide-lipid intermediate biosynthetic process|protein N-linked glycosylation beta-1,4-mannosyltransferase activity integral to membrane|endoplasmic reticulum
YEL040W UTR2 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0221228018554991 0.200164092478011 654 Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck cell wall chitin metabolic process|fungal-type cell wall organization transferase activity, transferring glycosyl groups cellular bud neck septin ring|fungal-type cell wall
YOL090W MSH2 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0220983124171722 0.200797078343136 655 Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP mismatch repair|mitotic recombination|meiotic gene conversion|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination|chromatin silencing at silent mating-type cassette loop DNA binding|single base insertion or deletion binding|ATP binding|Y-form DNA binding|double-strand/single-strand DNA junction binding|DNA insertion or deletion binding|guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity MutSbeta complex|nuclear chromosome|MutSalpha complex|nucleus
YLR441C RPS1A hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0220865440700009 0.200835502858012 656 Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YJR074W MOG1 hom FT PROTEIN LOCALIZATION|RNA LOCALIZATION|NUCLEUS 0.0220392444155568 0.201869141209445 657 Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p protein import into nucleus Ran GTPase binding nucleus
YGR268C HUA1 hom 0.0220218278779603 0.202158582366808 658 Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly biological_process molecular_function cytoplasm
YHR081W LRP1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION|NUCLEUS 0.0219903675239127 0.203411109438238 659 Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination U5 snRNA 3'-end processing|nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear retention of pre-mRNA at the site of transcription|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) double-stranded RNA binding|double-stranded DNA binding nuclear exosome (RNase complex)
YKR090W PXL1 hom FT SIGNALING|SITE OF POLARIZED GROWTH 0.0219878950068985 0.202854849770989 660 Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress maintenance of cell polarity|regulation of Rho protein signal transduction Rho GDP-dissociation inhibitor activity incipient cellular bud site|cellular bud|mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YIL159W BNR1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH 0.021984790256559 0.202918643113875 661 Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 barbed-end actin filament capping|actin filament bundle assembly|formin-nucleated actin cable assembly profilin binding cellular bud neck
YER101C AST2 hom FT PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS 0.0219347707710071 0.203948407942824 662 Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication protein targeting to membrane molecular_function cytoplasm
YGL200C EMP24 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.0219133250629198 0.204728794765877 663 Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles protein retention in ER lumen|vesicle organization|ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum|ER to Golgi transport vesicle
YLR406C RPL31B hom FT TRANSLATION|RIBOSOME 0.0219076917140305 0.204710057679365 664 Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication cytoplasmic translation|regulation of translational fidelity structural constituent of ribosome cytosolic large ribosomal subunit
YMR225C MRPL44 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0218688439226604 0.205311461590872 665 Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YGR086C PIL1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|MITOCHONDRION 0.0218242439735493 0.20630497889089 666 Primary protein component of eisosomes; eisosomes are large immobile cell cortex structures associated with endocytosis; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress eisosome assembly|endocytosis|negative regulation of protein kinase activity|response to heat|protein localization lipid binding mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YMR239C RNT1 het FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|NUCLEUS 0.0217937624649782 0.20687183579151 667 Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes U5 snRNA 3'-end processing|mRNA cleavage|chromatin organization|termination of RNA polymerase II transcription, exosome-dependent|U4 snRNA 3'-end processing|U1 snRNA 3'-end processing|rRNA transcription|rRNA processing ribonuclease III activity nucleoplasm|nucleolus
YCL030C HIS4 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 0.0217435950523099 0.207919219980379 668 Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis histidine biosynthetic process phosphoribosyl-ATP diphosphatase activity|phosphoribosyl-AMP cyclohydrolase activity|histidinol dehydrogenase activity intracellular
YNL278W CAF120 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|SITE OF POLARIZED GROWTH 0.021679402080008 0.209265025666804 669 Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter molecular_function CCR4-NOT complex
YKR067W GPT2 hom FT LIPID METABOLISM|ENDOPLASMIC RETICULUM 0.0216125589217374 0.21067308351569 670 Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen phospholipid biosynthetic process glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity integral to membrane|lipid particle|endoplasmic reticulum|cytoplasm
YER038W-A_d YER038W-A hom 0.0216087507093499 0.211162192102219 671 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria Unknown Unknown Unknown
YMR301C ATM1 het FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION 0.0216009679627864 0.210986006046104 672 Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol cellular iron ion homeostasis ATPase activity, coupled to transmembrane movement of substances|ATPase activity mitochondrion|integral to membrane|mitochondrial inner membrane
YBR163W EXO5 hom FT MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0215996383320199 0.210946045320202 673 Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 mitochondrial genome maintenance single-stranded DNA specific 5'-3' exodeoxyribonuclease activity mitochondrion
YNR011C PRP2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS 0.0215834588819749 0.211288214593244 674 RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16 generation of catalytic spliceosome for first transesterification step RNA-dependent ATPase activity U2-type catalytic step 1 spliceosome
YML005W TRM12 hom FT RNA PROCESSING 0.0215735703147044 0.211497539241786 675 S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA wybutosine biosynthetic process|tRNA methylation S-adenosylmethionine-dependent methyltransferase activity|transferase activity, transferring alkyl or aryl (other than methyl) groups cytoplasm
YKL126W YPK1 hom FF|FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0215185307396303 0.212870076950649 676 Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication eisosome assembly|protein autophosphorylation|negative regulation of phospholipid translocation|protein phosphorylation protein serine/threonine kinase activity cytosol|plasma membrane|cellular bud neck
YLR327C TMA10 hom FT NUCLEUS|MITOCHONDRION 0.0215109272106657 0.214333961899568 677 Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress biological_process molecular_function ribosome|nucleus|cytoplasm
YOR318C_d YOR318C hom 0.0215095879960885 0.212923785318741 678 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo Unknown Unknown Unknown
YHR134W WSS1 hom FT RESPONSE TO DNA DAMAGE|ENDOMEMBRANE SYSTEM|NUCLEUS 0.0214643479048158 0.213819571527991 679 Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response protein sumoylation|response to UV-B|response to UV-C|response to DNA damage stimulus molecular_function nuclear envelope
YNL196C_p SLZ1 hom 0.021435589577323 0.214502362497186 680 Sporulation-specific protein with a leucine zipper motif biological_process molecular_function cellular_component
YLL049W LDB18 hom FT CELL CYCLE|CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.0214161243019675 0.214850618755218 681 Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24 establishment of mitotic spindle orientation molecular_function dynactin complex|cell cortex|spindle pole body|astral microtubule
YMR202W ERG2 hom FF|FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0213004549195108 0.217818901716549 682 C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis ergosterol biosynthetic process C-8 sterol isomerase activity endoplasmic reticulum
YKR066C CCP1 hom FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION 0.0212799498444911 0.217781430306697 683 Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress cellular response to oxidative stress cytochrome-c peroxidase activity mitochondrion|mitochondrial intermembrane space
YHL020C OPI1 hom FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|SIGNALING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0212512343525141 0.218403109501369 684 Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance endoplasmic reticulum unfolded protein response|negative regulation of transcription from RNA polymerase II promoter|phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter transcription corepressor activity nuclear membrane|nucleoplasm|nuclear envelope|endoplasmic reticulum|nucleus
YBR091C TIM12 het FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0212300617286652 0.218862304176679 685 Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins protein import into mitochondrial inner membrane phospholipid binding|protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YJL129C TRK1 hom FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS 0.021212644993793 0.219240559901766 686 Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication cellular potassium ion homeostasis potassium ion transmembrane transporter activity membrane raft|integral to membrane|plasma membrane
YHL047C ARN2 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM|PLASMA MEMBRANE 0.0211980015043758 0.219558949301151 687 Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C cellular iron ion homeostasis|siderophore transport|siderophore metabolic process siderophore transmembrane transporter activity endosome|integral to membrane|cytoplasmic membrane-bounded vesicle|plasma membrane
YDR248C_p YDR248C hom FT KETONE METABOLISM|CARBOHYDRATE METABOLISM 0.0211795869692847 0.219959802230402 688 Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1 biological_process molecular_function cytoplasm
YPR060C ARO7 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.0211539086977475 0.220519650174046 689 Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis aromatic amino acid family biosynthetic process chorismate mutase activity nucleus|cytoplasm
YJL212C OPT1 hom FT PROTEIN LOCALIZATION|PLASMA MEMBRANE 0.0210934101356784 0.221842700590938 690 Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family oligopeptide transport|sulfur compound metabolic process oligopeptide transporter activity|proton-dependent oligopeptide secondary active transmembrane transporter activity integral to membrane|integral to plasma membrane
YBR285W_p YBR285W hom 0.0210769786367729 0.222203022528945 691 Putative protein of unknown function; YBR285W is not an essential gene biological_process molecular_function cellular_component
YPR028W YOP1 hom FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.0210344428108282 0.223137724598772 692 Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress vesicle-mediated transport|endoplasmic reticulum organization|endoplasmic reticulum inheritance|nuclear pore complex assembly protein binding integral to membrane|endoplasmic reticulum|endoplasmic reticulum tubular network
YJL185C ATG36 hom 0.0210279537489987 0.223280565125858 693 Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene peroxisome degradation molecular_function peroxisome
YPL007C TFC8 het FT NUCLEUS 0.020975917186593 0.22442838541892 694 One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter|transcription from RNA polymerase III promoter RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending transcription factor TFIIIC complex
YKR043C SHB17 hom FT CARBOHYDRATE METABOLISM|NUCLEUS 0.0209759141562344 0.224428452384961 695 Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus ribose phosphate biosynthetic process sedoheptulose-bisphosphatase activity nucleus|cytoplasm
YKR098C UBP11 hom FT PROTEOLYSIS 0.0209651373424751 0.224666692898959 696 Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins biological_process ubiquitin-specific protease activity cellular_component
YGL118C_d YGL118C hom 0.0208993094316034 0.226125857112327 697 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER144C UBP5 hom FT PROTEOLYSIS|SITE OF POLARIZED GROWTH 0.0208990619424975 0.226131355766898 698 Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck protein deubiquitination ubiquitin-specific protease activity incipient cellular bud site|cellular bud neck
YBR105C VID24 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM 0.020826588773774 0.227745652982022 699 GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles negative regulation of gluconeogenesis|vesicle fusion with vacuole|vacuolar protein catabolic process|proteasomal ubiquitin-dependent protein catabolic process|vesicle-mediated transport|protein targeting to vacuole molecular_function cytoplasmic membrane-bounded vesicle|GID complex|extrinsic to membrane
YKR081C RPF2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.020750380531185 0.229660420534753 700 Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles ribosomal large subunit assembly|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 7S RNA binding|5S rRNA binding|rRNA binding nucleolus|preribosome, large subunit precursor
YBR119W MUD1 hom FT RNA PROCESSING|NUCLEUS 0.0206408575204477 0.23192013464147 701 U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing mRNA splicing, via spliceosome U1 snRNA binding|RNA binding U1 snRNP|U2-type prespliceosome
YJL126W NIT2 hom 0.0206280589380583 0.232209781458571 702 Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member biological_process hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds cellular_component
YOR123C LEO1 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|RNA POL II, HOLOENZYME 0.0205598194073509 0.233967720844036 703 Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay chromatin organization|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription-coupled nucleotide-excision repair|histone H3-K4 trimethylation|transcription elongation from RNA polymerase II promoter RNA binding|RNA polymerase II transcription factor binding transcription factor activity nucleus|Cdc73/Paf1 complex
YOL005C RPB11 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0205581233533744 0.233866770960017 704 RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit termination of RNA polymerase II transcription|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity DNA-directed RNA polymerase II, core complex
YJL005W CYR1 het FT SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE 0.0205499356358345 0.233983367653674 705 Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation adenylate cyclase-modulating G-protein coupled receptor signaling pathway|Ras protein signal transduction adenylate cyclase activity mitochondrion|plasma membrane
YLR446W_p YLR446W hom FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.0204368066650269 0.236638542715222 706 Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene biological_process molecular_function cellular_component
YDR127W ARO1 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 0.0204269230265169 0.238128147376259 707 Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids aromatic amino acid family biosynthetic process shikimate kinase activity|shikimate 3-dehydrogenase (NADP+) activity|3-phosphoshikimate 1-carboxyvinyltransferase activity|3-dehydroquinate dehydratase activity|3-dehydroquinate synthase activity cytoplasm
YJL100W LSB6 hom FT LIPID METABOLISM|PLASMA MEMBRANE 0.0203863416369084 0.237728377014209 708 Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization phosphatidylinositol phosphorylation 1-phosphatidylinositol 4-kinase activity fungal-type vacuole membrane|plasma membrane|cytoplasm
YLR390W ECM19 hom FT CELL WALL ORG/BIOGENESIS|MITOCHONDRION 0.0203756528706105 0.238114525005685 709 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies fungal-type cell wall organization molecular_function mitochondrion
YIL008W URM1 hom FT RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS 0.0203612627095542 0.238306206172226 710 Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|invasive growth in response to glucose limitation|tRNA wobble uridine modification protein tag cytosol|nucleus|cytoplasm
YER086W ILV1 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION 0.0203423761332685 0.238742014612762 711 Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation threonine catabolic process|isoleucine biosynthetic process L-threonine ammonia-lyase activity mitochondrion
YPR069C SPE3 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.0203111649344155 0.239463445687899 712 Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells spermidine biosynthetic process|pantothenate biosynthetic process spermidine synthase activity nucleus|cytoplasm
YPL079W RPL21B hom FT TRANSLATION|RIBOSOME 0.0203074457699499 0.239549514648046 713 Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNL069C RPL16B hom FT TRANSLATION|RIBOSOME 0.020306867251945 0.239562904679768 714 Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YNL001W DOM34 hom FT CELL CYCLE|TRANSLATION|CELL DIVISION 0.0202952208900273 0.240042928418067 715 Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|nonfunctional rRNA decay ribosome binding|endoribonuclease activity cytoplasm
YBL104C SEA4 hom 0.0202709208893336 0.240395932614441 716 Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites biological_process molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane|cytoplasm
YBR224W_d YBR224W hom 0.0202707591071311 0.240399686392133 717 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1 Unknown Unknown Unknown
YLR444C_d YLR444C hom 0.0202452605202655 0.240991837545105 718 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL133W MRS3 hom FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION 0.0201543793708798 0.243110709652465 719 Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication mitochondrial iron ion transport|RNA splicing iron ion transmembrane transporter activity mitochondrion|integral to membrane
YHR203C RPS4B hom FT TRANSLATION|RIBOSOME 0.0201510102812115 0.2431895099808 720 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YLR108C YLR108C hom FT NUCLEUS 0.0201503283807298 0.243205461274006 721 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication biological_process molecular_function nucleus
YOR131C YOR131C hom FT NUCLEUS 0.0201123985078287 0.244093890026498 722 Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YML020W_p YML020W hom 0.0200955305721365 0.244489717440728 723 Putative protein of unknown function biological_process molecular_function cellular_component
YLR050C_p YLR050C hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0200738464935198 0.24499922309426 724 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene biological_process molecular_function integral to membrane|endoplasmic reticulum
YBL005W PDR3 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.020054197149664 0.245461561827697 725 Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YDR162C NBP2 hom FF|FT PROTEIN PHOSPHORYLATION|NUCLEUS 0.0199653959407631 0.248194074098857 726 Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM) negative regulation of protein kinase activity|response to heat|hyperosmotic response molecular_function nucleus|cytoplasm
YBR061C TRM7 hom FT RNA PROCESSING|TRANSLATION 0.0198708937394065 0.249874691049902 727 2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively cytoplasmic translation|tRNA methylation tRNA methyltransferase activity cytoplasm
YER146W LSM5 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0198659049897882 0.249923004642453 728 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex
YOL159C-A YOL159C-A hom FT NUCLEUS 0.0198134492123572 0.25160038681625 729 Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species biological_process molecular_function nucleus|cytoplasm
YIR033W MGA2 hom FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0198104461776833 0.251247788145304 730 ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette molecular_function integral to endoplasmic reticulum membrane|nucleus
YEL045C_d YEL045C hom 0.0197599592500538 0.252458056473741 731 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress Unknown Unknown Unknown
YDR392W SPT3 hom FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.0197434916805949 0.252853692629039 732 Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters conjugation with cellular fusion|histone acetylation|pseudohyphal growth|ascospore formation|chromatin modification|invasive growth in response to glucose limitation|transcription from RNA polymerase II promoter transcription cofactor activity SLIK (SAGA-like) complex|SAGA complex
YHL035C VMR1 hom FT NUCLEOTIDE METABOLISM|MITOCHONDRION 0.0196791362574939 0.254403982580678 733 Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions transport|response to drug|response to metal ion|drug transport ATPase activity, coupled to transmembrane movement of substances fungal-type vacuole membrane|mitochondrion|integral to membrane|ribosome
YPR124W CTR1 hom FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0196707879866917 0.254605571561403 734 High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress copper ion import copper uptake transmembrane transporter activity integral to membrane|plasma membrane
YBL069W AST1 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|GOLGI APPARATUS|PLASMA MEMBRANE 0.0196562046625772 0.254957987243053 735 Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication protein targeting to membrane|protein transport into membrane raft molecular_function late endosome|membrane raft|Golgi apparatus|plasma membrane
YDL013W SLX5 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0196496656423823 0.255116117044054 736 Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination SUMO binding|ubiquitin-protein ligase activity ubiquitin ligase complex|nucleus
YPR193C HPA2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION 0.0196423914866313 0.255362973806015 737 Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity protein homotetramerization|histone acetylation histone acetyltransferase activity|protein homodimerization activity cytoplasm
YBR197C YBR197C hom FT NUCLEUS 0.019631531373221 0.255555005424979 738 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YAR007C RFA1 het FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0196312412056267 0.256058710714862 739 Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination establishment of protein localization|telomere maintenance via telomerase|telomere maintenance via recombination|nucleotide-excision repair|DNA repair|mitotic recombination|heteroduplex formation|DNA unwinding involved in replication|reciprocal meiotic recombination|DNA replication|double-strand break repair via homologous recombination|protein ubiquitination double-stranded DNA binding|single-stranded DNA binding|sequence-specific DNA binding condensed nuclear chromosome|chromosome, telomeric region|DNA replication factor A complex|cytoplasm
YML091C RPM2 het FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION|NUCLEUS|MITOCHONDRION 0.0195426981871428 0.257712536714633 740 Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus cytoplasmic translation|tRNA 5'-leader removal|mRNA processing|mitochondrion organization|RNA processing|positive regulation of transcription from RNA polymerase II promoter ribonuclease P activity mitochondrion|nucleus|mitochondrial matrix|cytoplasmic mRNA processing body|mitochondrial ribonuclease P complex
YHR091C MSR1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0194896012585413 0.259008139228383 741 Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 arginyl-tRNA aminoacylation|mitochondrial arginyl-tRNA aminoacylation|mitochondrial translation arginine-tRNA ligase activity mitochondrion
YIR032C DAL3 hom FT PLASMA MEMBRANE 0.0194817689323279 0.259199634598819 742 Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression allantoin catabolic process ureidoglycolate hydrolase activity membrane
YLR009W RLP24 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.0194600315854112 0.260158310135764 743 Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp ribosomal large subunit biogenesis molecular_function nucleolus|preribosome, large subunit precursor
YGL186C TPN1 hom FF|FT PLASMA MEMBRANE 0.0193760027853149 0.262008635746383 744 Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p vitamin transport vitamin transporter activity integral to membrane|plasma membrane
YHR066W SSF1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.0193129166152063 0.263636745158751 745 Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication conjugation with cellular fusion|ribosomal large subunit assembly|regulation of cell size rRNA binding nucleolus
YNL119W NCS2 hom FT RNA PROCESSING 0.0192977170575663 0.26436957669216 746 Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae tRNA wobble position uridine thiolation|pseudohyphal growth|protein urmylation|invasive growth in response to glucose limitation molecular_function cytosol|cytoplasm
YOR118W RTC5 hom 0.0192723695341132 0.264355686020734 747 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity biological_process molecular_function cytoplasm
YBR289W SNF5 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|CHROMOSOME|RSC COMPLEX 0.0192434084527448 0.265074321558767 748 Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions sucrose catabolic process|double-strand break repair via homologous recombination|chromatin remodeling|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding SWI/SNF complex|nucleus
YDR265W PEX10 hom FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION 0.019164105350788 0.26704901724618 749 Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders protein import into peroxisome matrix|protein ubiquitination ubiquitin-protein ligase activity|protein binding peroxisomal membrane
YER128W VFA1 hom FT VACUOLAR TRANSPORT 0.0190989204271535 0.268679715947116 750 Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology vacuolar transport molecular_function endosome|cytoplasm
YHR190W ERG9 het FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.0190949536597945 0.268779170732192 751 Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway ergosterol biosynthetic process squalene synthase activity|farnesyl-diphosphate farnesyltransferase activity mitochondrial outer membrane|integral to membrane|endoplasmic reticulum
YDL122W UBP1 hom FT PROTEOLYSIS|ENDOPLASMIC RETICULUM 0.0190426811214643 0.270879152726916 752 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains protein deubiquitination ubiquitin-specific protease activity endoplasmic reticulum|cytoplasm
YNL230C ELA1 hom FT PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0189689126779937 0.271952430706451 753 Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity elongin complex|Cul3-RING ubiquitin ligase complex
YPL034W_p YPL034W hom 0.0189418883443862 0.272636130697429 754 Putative protein of unknown function; YPL034W is not essential gene biological_process molecular_function cellular_component
YPR161C SGV1 het FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0188678831204757 0.274514433394175 755 Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins phosphorylation of RNA polymerase II C-terminal domain|protein phosphorylation|transcription, DNA-dependent|positive regulation of histone H3-K4 methylation RNA polymerase II carboxy-terminal domain kinase activity|cyclin-dependent protein kinase activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YOL087C DUF1 hom 0.0188636984559053 0.274620906271355 756 Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid biological_process ubiquitin binding cytoplasm
YFR021W ATG18 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|VACUOLAR PROTEIN PROCESSING 0.0188383055684152 0.275267596914739 757 Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood piecemeal microautophagy of nucleus|peroxisome degradation|vacuolar protein processing|macroautophagy|late endosome to vacuole transport|CVT pathway ubiquitin binding|phosphatidylinositol binding cytosol|endosome|fungal-type vacuole membrane|PAS complex|pre-autophagosomal structure
YMR216C SKY1 hom FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS 0.0188220844140862 0.275681250815189 758 SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 cellular cation homeostasis|cellular ion homeostasis|response to drug|protein phosphorylation|positive regulation of protein import into nucleus|regulation of cell size|mRNA splice site selection protein serine/threonine kinase activity|protein kinase activity cytoplasm
YKR100C SKG1 hom FT CELL WALL ORG/BIOGENESIS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0188128074590183 0.275989618181272 759 Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell fungal-type cell wall organization molecular_function incipient cellular bud site|cellular bud|cellular bud tip
YMR299C DYN3 hom FT CYTOSKELETON 0.0188104032500863 0.275979393331476 760 Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration nuclear migration along microtubule motor activity cytoplasmic dynein complex|cytoplasmic microtubule
YOR006C TSR3 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0188043738021713 0.276133371067532 761 Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress maturation of SSU-rRNA molecular_function nucleus|cytoplasm
YKR024C DBP7 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0188043079712044 0.276493347756682 762 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ATP-dependent RNA helicase activity nucleolus
YOR282W_d YOR282W het 0.0187877179522431 0.277276317245761 763 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C Unknown Unknown Unknown
YDR285W ZIP1 hom FT CELL CYCLE|NUCLEUS|CHROMOSOME 0.018769722956016 0.277019406371665 764 Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate synapsis|reciprocal meiotic recombination chromatin binding|SUMO polymer binding transverse filament
YNL112W DBP2 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION 0.0187514656322581 0.277845509756197 765 ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|rRNA processing RNA helicase activity mitochondrion|nucleus|cytoplasm
YJR007W SUI2 het FF|FT TRANSLATION|RIBOSOME 0.0187128684966512 0.278692483102057 766 Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress translational initiation translation initiation factor activity ribosome|multi-eIF complex|eukaryotic translation initiation factor 2 complex|cytoplasm
YBL065W_d YBL065W hom 0.0186606193840158 0.282273058867724 767 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene Unknown Unknown Unknown
YBL091C-A SCS22 hom FT LIPID METABOLISM 0.0186279474742955 0.28066481539209 768 Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication phospholipid biosynthetic process|chromatin silencing at telomere molecular_function cellular_component
YER186C_p YER186C hom 0.0185709764239538 0.282138817021425 769 Putative protein of unknown function biological_process molecular_function cellular_component
YKR047W_d YKR047W hom 0.0185623180811196 0.282363291259853 770 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 Unknown Unknown Unknown
YDL089W NUR1 hom FT ENDOMEMBRANE SYSTEM|NUCLEUS 0.0184911963106219 0.284499145983892 771 Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate maintenance of rDNA molecular_function nuclear periphery
YLR073C RFU1 hom 0.018484634415802 0.284382714653477 772 Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes regulation of ubiquitin homeostasis enzyme inhibitor activity endosome
YJL086C_d YJL086C het FF 0.0184649165329911 0.28518428777699 773 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 Unknown Unknown Unknown
YPL205C_d YPL205C hom 0.0184461795087952 0.285385974322744 774 Hypothetical protein; deletion of locus affects telomere length Unknown Unknown Unknown
YKR077W MSA2 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS 0.0184261545486116 0.28590935644933 775 Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation regulation of transcription involved in G1 phase of mitotic cell cycle molecular_function nucleus|cytoplasm
YEL027W VMA3 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT 0.0184091024500725 0.286571190958023 776 Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis cellular copper ion homeostasis|cellular iron ion homeostasis|endocytosis|vacuole organization|proton transport|vacuolar acidification|protein targeting to vacuole hydrogen ion transmembrane transporter activity vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YLR425W TUS1 hom FT SIGNALING|CELL WALL ORG/BIOGENESIS|SITE OF POLARIZED GROWTH 0.0183920646035028 0.286801838376709 777 Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate fungal-type cell wall organization|signal transduction Rho guanyl-nucleotide exchange factor activity incipient cellular bud site|cellular bud neck
YDR538W PAD1 hom FT KETONE METABOLISM|MITOCHONDRION 0.0183623504445055 0.287581293408983 778 Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX cinnamic acid catabolic process|aromatic compound catabolic process mRNA binding|carboxy-lyase activity mitochondrion
YOL108C INO4 hom FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|NUCLEUS 0.0183136506031811 0.288861863362938 779 Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YGL008C PMA1 het FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION|PLASMA MEMBRANE 0.0182834314758198 0.289658408306506 780 Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+] proton transport|regulation of pH|transmembrane transport hydrogen-exporting ATPase activity, phosphorylative mechanism mitochondrion|integral to membrane|membrane raft|plasma membrane
YLR015W BRE2 hom FT CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.018240226785512 0.290799804851423 781 Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L histone H3-K4 methylation|telomere maintenance|histone H3-K4 trimethylation|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YGR180C RNR4 hom FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.0182358116755368 0.291276558195327 782 Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress cofactor biosynthetic process|deoxyribonucleotide biosynthetic process ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ribonucleoside-diphosphate reductase complex|nucleus|cytoplasm
YOL063C CRT10 hom FT TRANSCRIPTION FROM RNA POL II 0.0182221097320256 0.291279326160459 783 Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YLL027W ISA1 hom FT KETONE METABOLISM|COFACTOR METABOLISM|MITOCHONDRION 0.0182048867880267 0.2918796115156 784 Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins biotin biosynthetic process|iron-sulfur cluster assembly iron-sulfur cluster binding|iron ion binding mitochondrial matrix
YER013W PRP22 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS 0.0181951070215098 0.292066979734337 785 DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes spliceosomal complex disassembly|generation of catalytic spliceosome for second transesterification step second spliceosomal transesterification activity|ATP-dependent RNA helicase activity U2-type post-spliceosomal complex|U2-type catalytic step 2 spliceosome
YKL019W RAM2 het FT PROTEIN PRENYLATION 0.0181121438527522 0.294201295242105 786 Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor protein farnesylation|protein geranylgeranylation|peptide pheromone maturation protein geranylgeranyltransferase activity|protein farnesyltransferase activity|CAAX-protein geranylgeranyltransferase activity CAAX-protein geranylgeranyltransferase complex|protein farnesyltransferase complex
YAL023C PMT2 hom FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0180534116771724 0.295769923440113 787 Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication ER-associated misfolded protein catabolic process|protein O-linked glycosylation|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YMR243C ZRC1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION 0.0180372717865668 0.296201968723621 788 Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication cobalt ion transport|cellular zinc ion homeostasis|zinc ion transport|glutathione metabolic process zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity integral to membrane|fungal-type vacuole
YMR273C ZDS1 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CELL WALL ORG/BIOGENESIS|RNA LOCALIZATION|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|SITE OF POLARIZED GROWTH|NUCLEAR PORE 0.0180315433895037 0.296355412414326 789 Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication mRNA export from nucleus|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|chromatin silencing|establishment of cell polarity|regulation of protein localization|cell aging protein phosphatase type 2A regulator activity incipient cellular bud site|nuclear pore|cellular bud neck|cellular bud tip|cytoplasm
YOR319W HSH49 het FF|FT RNA PROCESSING|NUCLEUS 0.0180080627610981 0.296984931689679 790 U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) mRNA splicing, via spliceosome RNA binding U2 snRNP|U2-type prespliceosome
YCR033W SNT1 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|NUCLEUS|CHROMOSOME 0.017994737182884 0.297630882507614 791 Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation|positive regulation of stress-activated MAPK cascade molecular_function Rpd3L-Expanded complex|Set3 complex
YNL283C WSC2 hom FF|FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0179928877439354 0.297392251388534 792 Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response fungal-type cell wall organization|response to heat|Rho protein signal transduction transmembrane signaling receptor activity site of polarized growth|cellular bud|mating projection tip|cytoplasm
YPR115W RGC1 hom FT CELL CYCLE 0.0179368089765518 0.298900724772304 793 Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication positive regulation of glycerol transport molecular_function cytoplasm
YBR200W-A_p YBR200W-A hom 0.01788021255598 0.300428289719822 794 Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YKR026C GCN3 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION 0.0178545025746042 0.301123929581848 795 Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression regulation of translational initiation enzyme regulator activity|guanyl-nucleotide exchange factor activity|translation initiation factor activity eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YMR135C GID8 hom FT KETONE METABOLISM|CELL CYCLE|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS 0.0178134768571445 0.302236189449105 796 Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|traversing start control point of mitotic cell cycle molecular_function nucleus|GID complex|cytoplasm
YER117W RPL23B hom FT TRANSLATION|RIBOSOME 0.0177903446819224 0.303225258077989 797 Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YHR098C SFB3 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH 0.0177364545157914 0.304331735165107 798 Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p cargo loading into COPII-coated vesicle signal sequence binding COPII vesicle coat|mating projection tip
YBR221C PDB1 hom FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.0177135156290814 0.30495769234813 799 E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria acetyl-CoA biosynthetic process from pyruvate pyruvate dehydrogenase (acetyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YPL182C_d YPL182C hom 0.0176804623278199 0.305861152870455 800 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W Unknown Unknown Unknown
YBL013W FMT1 hom FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION 0.0175470258804874 0.309526448983059 801 Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate translational initiation|methionyl-tRNA aminoacylation methionyl-tRNA formyltransferase activity mitochondrion
YER178W PDA1 hom FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.0175449806428509 0.309582853318643 802 E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose acetyl-CoA biosynthetic process from pyruvate pyruvate dehydrogenase (acetyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YIR025W MND2 hom FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CHROMOSOME SEGREGATION|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0175425300579293 0.309650445412549 803 Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|reciprocal meiotic recombination|regulation of mitotic metaphase/anaphase transition|protein ubiquitination|mitotic sister chromatid segregation molecular_function nucleus|anaphase-promoting complex
YJL195C_d YJL195C het FF 0.0175398562509559 0.309724205538126 804 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6 Unknown Unknown Unknown
YER182W_p FMP10 hom FT MITOCHONDRION 0.0175363671617599 0.309820473631831 805 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YPR101W SNT309 hom FT RNA PROCESSING|NUCLEUS 0.0175187646755344 0.310306448221877 806 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p mRNA splicing, via spliceosome first spliceosomal transesterification activity Prp19 complex|U2-type catalytic step 1 spliceosome
YNR051C BRE5 hom FT VESICLE-MEDIATED TRANSPORT 0.0175121231199221 0.310489940863746 807 Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown molecular_function cytoplasm
YBL075C SSA3 hom FT PROTEIN LOCALIZATION 0.0174412892380945 0.312451389055815 808 ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress unfolded protein binding|ATPase activity cytosol
YPL022W RAD1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS 0.017427843248369 0.312824638970298 809 Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein mitotic recombination|meiotic mismatch repair|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair via single-strand annealing, removal of nonhomologous ends|removal of nonhomologous ends single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity nucleotide-excision repair factor 1 complex|nucleus
YDR525W-A SNA2 hom 0.0173806676760104 0.314136515576678 810 Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function fungal-type vacuole membrane|integral to membrane|cytoplasm
YDL130W RPP1B hom FT TRANSLATION|RIBOSOME 0.0173319222012597 0.31592915366553 811 Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component cytoplasmic translation|translational elongation structural constituent of ribosome cytosolic large ribosomal subunit
YMR247C RKR1 hom FT CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING|NUCLEUS 0.0172373597484256 0.318143828229304 812 RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice chromatin modification|chromatin silencing at telomere|ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity|ribosome binding ribosome|nucleus
YPR164W MMS1 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0172199357920631 0.318633326000819 813 Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay replication fork processing|negative regulation of transposition, RNA-mediated|recombinational repair|nonfunctional rRNA decay molecular_function Cul8-RING ubiquitin ligase complex
YKL182W FAS1 het FF|FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.0171919902238818 0.319635996567499 814 Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities fatty acid biosynthetic process palmitoyltransferase activity|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|fatty acid synthase activity|3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity cytosol|fatty acid synthase complex|mitochondrion|lipid particle|cytoplasm
YMR146C TIF34 het FT TRANSLATION 0.017149898129604 0.320678053002272 815 eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation translation reinitiation|translational initiation translation initiation factor activity multi-eIF complex|eukaryotic translation initiation factor 3 complex
YDR174W HMO1 hom FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.0171356950745146 0.321367901121619 816 Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase regulation of transcription from RNA polymerase I promoter|regulation of transcription by chromatin organization|regulation of ribosomal protein gene transcription from RNA polymerase II promoter double-stranded DNA binding|four-way junction DNA binding|DNA binding, bending nuclear chromatin|nucleolus|cytoplasm
YKL211C TRP3 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0170666044001222 0.324119214271478 817 Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p tryptophan biosynthetic process indole-3-glycerol-phosphate synthase activity|anthranilate synthase activity anthranilate synthase complex|cytoplasm
YJR142W_p YJR142W hom 0.017038799384933 0.323751242953115 818 Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member biological_process molecular_function cellular_component
YGR228W_d YGR228W hom 0.0170062237755775 0.324677298649901 819 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Unknown Unknown Unknown
YKL038W RGT1 hom FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|NUCLEUS 0.0169793651943465 0.32544212634464 820 Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication glucose transport|regulation of glucose import|negative regulation of transcription from RNA polymerase II promoter|glucose metabolic process|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription nucleus
YCR066W RAD18 hom FF|FT RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0169637058250854 0.325960727092456 821 E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA protein monoubiquitination|error-free translesion synthesis|error-free postreplication DNA repair|error-prone translesion synthesis ubiquitin-protein ligase activity|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding nuclear chromatin|nucleus
YMR001C CDC5 het FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0169594186288759 0.326516323773947 822 Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate synaptonemal complex disassembly|spindle assembly involved in meiosis|protein phosphorylation|resolution of meiotic recombination intermediates|positive regulation of spindle pole body separation protein kinase activity nucleus|cellular bud neck|spindle pole
YIR021W MRS1 hom FT RNA PROCESSING|MITOCHONDRION 0.0169514640274587 0.326598798534501 823 Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA Group I intron splicing endodeoxyribonuclease activity|RNA binding mitochondrion
YER044C-A MEI4 hom FT CELL CYCLE|NUCLEUS|CHROMOSOME 0.0169159571622957 0.327252382868136 824 Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores meiotic DNA double-strand break formation molecular_function condensed nuclear chromosome
YML081W TDA9 hom FT NUCLEUS 0.0169088953990762 0.327454395094729 825 DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication biological_process sequence-specific DNA binding nucleus
YBR226C_d YBR226C hom 0.0169031393697934 0.327619114703872 826 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W Unknown Unknown Unknown
YDR316W OMS1 hom FT MITOCHONDRION 0.0168514734526008 0.329172161336548 827 Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations biological_process S-adenosylmethionine-dependent methyltransferase activity mitochondrial envelope|mitochondrion
YML085C TUB1 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION|NUCLEUS|CYTOSKELETON 0.0168480185707655 0.329415651573632 828 Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation structural constituent of cytoskeleton tubulin complex|cytoplasmic microtubule|kinetochore microtubule|nuclear microtubule|spindle pole body|polar microtubule
YGR072W UPF3 hom FT NUCLEUS 0.0168322487662314 0.330085218406418 829 Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|translational frameshifting|protein ubiquitination molecular_function nucleolus|nucleus|polysome|cytoplasm
YMR021C MAC1 hom FF|FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS|NUCLEUS 0.0167768553043514 0.331246493625679 830 Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport cellular copper ion homeostasis|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter core promoter proximal region DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YIL143C SSL2 het FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|RNA LOCALIZATION|NUCLEUS|RNA POL II, HOLOENZYME 0.0167511842542134 0.331987030958111 831 Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3 poly(A)+ mRNA export from nucleus|promoter clearance from RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|nucleotide-excision repair, DNA incision|transcription from RNA polymerase II promoter|phosphorylation of RNA polymerase II C-terminal domain|regulation of transposition, RNA-mediated|regulation of mitotic recombination ATP-dependent DNA helicase activity|core RNA polymerase binding transcription factor activity core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YDR041W RSM10 het FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.01674902856499 0.332049265138723 832 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YJR044C VPS55 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT 0.0167393965142328 0.332543785638792 833 Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP) late endosome to vacuole transport via multivesicular body sorting pathway molecular_function Vps55/Vps68 complex|late endosome|integral to membrane
YCR020W-B HTL1 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|RSC COMPLEX 0.0167303862239007 0.333237382238476 834 Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance regulation of cell cycle|nucleosome disassembly|response to DNA damage stimulus|chromatin remodeling|transcription elongation from RNA polymerase II promoter chromatin binding RSC complex
YDR241W_d BUD26 hom 0.0167125037037854 0.333104873566118 835 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay Unknown Unknown Unknown
YPR165W RHO1 het FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|CYTOSKELETON ORGANIZATION|MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0166111074301566 0.336046671463122 836 GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process|regulation of fungal-type cell wall organization|positive regulation of endocytosis|budding cell bud growth|small GTPase mediated signal transduction|regulation of protein localization|positive regulation of protein kinase C signaling cascade|actin cytoskeleton organization|regulation of vacuole fusion, non-autophagic|actin cytoskeleton reorganization|regulation of exocyst localization|regulation of cell size GTPase activity|signal transducer activity incipient cellular bud site|mitochondrion|Golgi apparatus|peroxisome|cellular bud neck|cellular bud tip|mitochondrial outer membrane|1,3-beta-D-glucan synthase complex|plasma membrane|mating projection tip
YAL038W CDC19 het FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.0166065826745821 0.336683177562872 837 Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication pyruvate metabolic process|glycolysis pyruvate kinase activity cytosol|plasma membrane
YKL055C OAR1 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.016553572903316 0.337723323036262 838 Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p fatty acid metabolic process|aerobic respiration 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity mitochondrion
YNL324W_d YNL324W hom 0.016553209901099 0.337733918548758 839 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR089W NNF2 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0165375191221402 0.338192113847958 840 Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation biological_process molecular_function integral to membrane
YNL189W SRP1 het FT PROTEIN LOCALIZATION|NUCLEUS 0.0165325296187529 0.338554058230082 841 Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation protein targeting to membrane|protein import into nucleus protein transporter activity integral to membrane|nuclear exosome (RNase complex)|nucleus|cytoplasm
YER180C-A SLO1 hom FT PROTEIN LOCALIZATION 0.0164451428271884 0.340897730735003 842 Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO intracellular protein transport small GTPase regulator activity cytoplasm
YLR284C ECI1 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS 0.0163847216876528 0.342818851843585 843 Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced fatty acid beta-oxidation dodecenoyl-CoA delta-isomerase activity peroxisome
YLR190W MMR1 hom FT CELL CYCLE|CELL DIVISION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|SITE OF POLARIZED GROWTH 0.01638226114681 0.342747381367246 844 Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p mitochondrion inheritance molecular_function mitochondrial outer membrane|incipient cellular bud site|mitochondrion|cellular bud|cellular bud neck
YBR218C PYC2 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM 0.0163720579438606 0.343048109829847 845 Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication NADPH regeneration|gluconeogenesis pyruvate carboxylase activity cytosol
YGL014W PUF4 hom FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|TRANSLATION|GENE SILENCING 0.0163533257397585 0.343600660048326 846 Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of translation|protein localization|negative regulation of chromatin silencing involved in replicative cell aging mRNA binding cytoplasm
YKR071C DRE2 het FT COFACTOR METABOLISM|MITOCHONDRION 0.0163422338262284 0.343928109667727 847 Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress iron-sulfur cluster assembly electron carrier activity cytosol|cytoplasm|mitochondrial intermembrane space
YHR111W UBA4 hom FT RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS 0.0163139773311891 0.344979066627737 848 Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|tRNA thio-modification|Unknown|invasive growth in response to glucose limitation URM1 activating enzyme activity|sulfurtransferase activity|thiosulfate sulfurtransferase activity|protein adenylyltransferase activity cytoplasm
YER162C RAD4 hom FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS 0.0162474473408545 0.346734464211063 849 Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair damaged DNA binding cytosol|nucleotide-excision repair factor 2 complex|nucleus
YGL113W SLD3 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0162320561391659 0.347191524636845 850 Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress DNA unwinding involved in replication|double-strand break repair via break-induced replication|DNA replication initiation chromatin binding nuclear chromatin|DNA replication preinitiation complex
YDR170C SEC7 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS|GOLGI APPARATUS 0.0162164560182558 0.347655180025063 851 Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|autophagic vacuole assembly ARF guanyl-nucleotide exchange factor activity trans-Golgi network|cytosol|late endosome|integral to membrane|Golgi-associated vesicle
YPL025C_d YPL025C hom 0.0161864777904407 0.34854727544168 852 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER090W TRP2 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0160873476964349 0.3528755610981 853 Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p tryptophan biosynthetic process anthranilate synthase activity anthranilate synthase complex|cytoplasm
YER167W BCK2 hom FT CELL CYCLE|NUCLEUS 0.0160666737345714 0.352198724715903 854 Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations regulation of cell cycle|positive regulation of gene expression|G1/S transition of mitotic cell cycle molecular_function nucleus|cytoplasm
YMR054W STV1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0160620053318099 0.352266873634129 855 Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|late endosome|integral to membrane|Golgi apparatus
YDL140C RPO21 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION|RNA POL II, HOLOENZYME 0.0160320673030928 0.353165241973861 856 RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity mitochondrion|DNA-directed RNA polymerase II, core complex
YIL068C SEC6 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH 0.0159893198939599 0.354522257095464 857 Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p exocyst localization|Golgi to plasma membrane transport|exocytosis|vesicle fusion|negative regulation of SNARE complex assembly|vesicle docking involved in exocytosis protein homodimerization activity mating projection tip|cellular bud neck|cellular bud tip|exocyst
YNL127W FAR11 hom FT CELL CYCLE|SIGNALING 0.0159658343600079 0.355157874289587 858 Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 re-entry into mitotic cell cycle after pheromone arrest molecular_function cellular_component
YMR156C TPP1 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.0159206135627844 0.35652241761545 859 DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase DNA repair polynucleotide 3'-phosphatase activity cellular_component
YGR062C COX18 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0159187909878801 0.356577483190658 860 Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC protein insertion into mitochondrial membrane from inner side membrane insertase activity integral to membrane|integral to mitochondrial inner membrane
YBR081C SPT7 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION|HISTONE ACETYLTRANSFERASE 0.015914088034187 0.356719598584553 861 Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex conjugation with cellular fusion|histone acetylation|protein complex assembly|chromatin modification structural molecule activity SLIK (SAGA-like) complex|mitochondrion|SAGA complex
YER135C_d YER135C hom 0.0158451069893167 0.358808187733241 862 Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Unknown Unknown Unknown
YLR331C_d JIP3 hom 0.0157560140165001 0.361588663794589 863 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 Unknown Unknown Unknown
YNL197C WHI3 hom FT PROTEIN LOCALIZATION|CELL CYCLE 0.0157346817520154 0.362239153464638 864 RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci;; Tpk1 (PKA) mediated phosphorylation of Whi3 affects G1/S transition by modulating Cln3 transcription; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; WHI3 has a paralog, WHI4, that arose from the whole genome duplication pseudohyphal growth|invasive growth in response to glucose limitation|regulation of cell size|cytoplasmic sequestering of protein RNA binding cytoplasm
YDR413C_d YDR413C het 0.0157077888925729 0.363131825981622 865 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing Unknown Unknown Unknown
YBL067C UBP13 hom FT PROTEOLYSIS 0.0156925390790762 0.363454824399529 866 Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication biological_process ubiquitin-specific protease activity cellular_component
YDR176W NGG1 hom FF|FT CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.0156829771418323 0.363747292299396 867 Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex histone acetylation|chromatin modification histone acetyltransferase activity|transcription cofactor activity SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YOR116C RPO31 het FF|FT NUCLEUS 0.0156791115728378 0.363865568966461 868 RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YFR012W DCV1 hom 0.0156583095633208 0.364502470722458 869 Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YNL195C_p YNL195C hom FT MITOCHONDRION 0.0155983122443257 0.366343325422298 870 Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YPR062W FCY1 hom FT NUCLEUS 0.0155768327218937 0.367003772737682 871 Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) cytosine metabolic process|pyrimidine-containing compound salvage|cytidine metabolic process cytosine deaminase activity nucleus|cytoplasm
YKL012W PRP40 het FT RNA PROCESSING|NUCLEUS 0.0155548991226361 0.367678946873216 872 U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex mRNA splicing, via spliceosome RNA binding U1 snRNP|nucleus|U2-type prespliceosome
YPR143W RRP15 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0154780994458206 0.37004913255287 873 Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus|nucleus|preribosome, large subunit precursor
YPR169W JIP5 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.0154593614055922 0.370628861279069 874 Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein ribosomal large subunit biogenesis molecular_function nucleolus|nucleus
YFR034C PHO4 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.015422899396574 0.372043930587671 875 Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability cellular response to phosphate starvation|positive regulation of phosphate metabolic process|phosphate-containing compound metabolic process|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YHR171W ATG7 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|MITOCHONDRION 0.0154135959192355 0.37204714917895 876 Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation C-terminal protein lipidation|protein modification by small protein conjugation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway APG8 activating enzyme activity|APG12 activating enzyme activity cytosol|mitochondrion|membrane|pre-autophagosomal structure
YDL145C COP1 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.015353973582122 0.373899902821009 877 Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport ubiquitin binding COPI vesicle coat
YDR493W MZM1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0153046264707399 0.375437663465386 878 Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog mitochondrial respiratory chain complex III assembly molecular_function mitochondrion|mitochondrial matrix
YBR288C APM3 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0152810929817417 0.376172390067327 879 Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway Golgi to vacuole transport|vesicle-mediated transport molecular_function AP-3 adaptor complex
YNL235C_d YNL235C hom 0.0152445966990154 0.377313574342013 880 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex Unknown Unknown Unknown
YOL051W GAL11 hom FF|FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0151578807157562 0.380389023193195 881 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|TFIIE-class binding transcription factor activity|RNA polymerase II activating transcription factor binding|TFIIE-class transcription factor binding|TFIIH-class transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex
YDL173W PAR32 hom 0.0151540711176333 0.38015336883204 882 Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene biological_process molecular_function cytoplasm
YNR030W ALG12 hom FT LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0151527803575022 0.380976450903226 883 Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation dolichol-linked oligosaccharide biosynthetic process|protein glycosylation alpha-1,6-mannosyltransferase activity integral to membrane|endoplasmic reticulum
YER161C SPT2 hom FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION|NUCLEUS 0.0151370990227215 0.380687242614803 884 Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins negative regulation of transcription from RNA polymerase II promoter|chromatin organization|RNA polyadenylation|transcription elongation from RNA polymerase II promoter DNA binding|DNA secondary structure binding nucleus
YDL067C COX9 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0150334082265382 0.383958924416868 885 Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YDR005C MAF1 hom FT NUCLEUS 0.0150282557675904 0.384121943625788 886 Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions negative regulation of transcription from RNA polymerase III promoter RNA polymerase III core binding nucleolus|nucleus|cytoplasm
YNL216W RAP1 het FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0149923042681485 0.385260594874569 887 Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain) negative regulation of chromatin silencing|establishment of protein localization to chromatin|establishment of chromatin silencing at telomere|regulation of transcription by chromatin organization|protection from non-homologous end joining at telomere|negative regulation of transcription from RNA polymerase II promoter|telomere maintenance via telomere lengthening|telomere maintenance|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|establishment of protein localization to telomere|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere core promoter proximal region sequence-specific DNA binding|DNA binding, bending|sequence-specific DNA binding|TFIID-class transcription factor binding|TBP-class protein binding RNA polymerase II transcription factor activity|telomeric DNA binding|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|G-quadruplex DNA binding|nucleosomal DNA binding nuclear chromosome|nuclear nucleosome|nuclear chromosome, telomeric region|nuclear telomere cap complex
YNL055C POR1 hom FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION 0.0149393578914266 0.386941255351457 888 Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication DNA transport|mitochondrion organization|apoptotic process|ion transport|cell redox homeostasis voltage-gated anion channel activity mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YNL307C MCK1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION 0.0148936909926441 0.388394430509484 889 Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family meiosis|double-strand break repair via nonhomologous end joining|ascospore formation|protein phosphorylation|response to stress|mitotic sister chromatid segregation protein serine/threonine/tyrosine kinase activity|protein serine/threonine kinase activity|protein kinase activity cellular_component
YDL196W_d YDL196W het FF 0.0147358448927669 0.393654508572403 890 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Unknown Unknown Unknown
YDL126C CDC48 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION|SITE OF POLARIZED GROWTH|UBIQUITI 0.0147119522764898 0.394351467087792 891 AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP proteasomal ubiquitin-dependent protein catabolic process|mitotic spindle disassembly|ER-associated protein catabolic process|mitochondria-associated protein catabolic process|macroautophagy|sister chromatid biorientation|ER-associated misfolded protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|retrograde protein transport, ER to cytosol|piecemeal microautophagy of nucleus|endoplasmic reticulum membrane fusion|ribophagy|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process ubiquitin binding|ATPase activity mitochondrion|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytosol|Doa10p ubiquitin ligase complex|nucleus|endoplasmic reticulum membrane|mating projection tip
YNL267W PIK1 het FF|FT LIPID METABOLISM|SIGNALING|NUCLEUS|GOLGI APPARATUS 0.0146075105009312 0.398351576574348 892 Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton phosphatidylinositol phosphorylation 1-phosphatidylinositol 4-kinase activity trans-Golgi network|nucleus
YGR106C VOA1 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.014590661670293 0.398473039040995 893 Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval protein complex assembly molecular_function fungal-type vacuole membrane|endoplasmic reticulum membrane
YMR242W-A_p YMR242W-A hom 0.0145801577929647 0.398460866632437 894 Putative protein of unknown function biological_process molecular_function cellular_component
YDR159W SAC3 hom FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0145792099413801 0.399054722958127 895 Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP) ribosomal small subunit biogenesis|actin filament-based process|mRNA export from nucleus|mRNA 3'-end processing|mitosis|protein export from nucleus|transcription-coupled nucleotide-excision repair|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery protein binding transcription export complex 2|nuclear pore
YDR290W_d YDR290W hom 0.0145693076234127 0.39881201568866 896 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103 Unknown Unknown Unknown
YDR213W UPC2 hom FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|NUCLEUS 0.0144875093456582 0.401465280161131 897 Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication cellular response to hypoxia|positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|membrane|cytoplasm|perinuclear region of cytoplasm
YNL268W LYP1 hom FT MITOCHONDRION|PLASMA MEMBRANE 0.0143354643113553 0.406425166801815 898 Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids basic amino acid transport basic amino acid transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YKL037W AIM26 hom FF|FT MITOCHONDRION 0.0142832687373495 0.408136241048065 899 Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT mitochondrion degradation molecular_function mitochondrion|integral to membrane
YNR052C POP2 hom FF|FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS|SITE OF POLARIZED GROWTH 0.0141632842276662 0.412085798481105 900 RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter 3'-5'-exoribonuclease activity CCR4-NOT core complex|mating projection tip|cytoplasmic mRNA processing body|cytoplasm
YDR108W TRS85 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|GOLGI APPARATUS 0.0141449987513058 0.412689688840452 901 Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role meiosis|vesicle organization|piecemeal microautophagy of nucleus|ER to Golgi vesicle-mediated transport|peroxisome degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway molecular_function TRAPP complex|pre-autophagosomal structure
YAL044C GCV3 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION 0.0139969773635642 0.417597462544722 902 H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF glycine catabolic process|one-carbon metabolic process|protein lipoylation glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YKR020W VPS51 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL DIVISION|VACUOLAR TRANSPORT|GOLGI APPARATUS 0.0139477973600643 0.419374366231984 903 Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p vesicle organization|retrograde transport, endosome to Golgi|budding cell apical bud growth|regulation of cell size|protein targeting to vacuole protein binding Golgi apparatus|GARP complex
YOL020W TAT2 hom FT PLASMA MEMBRANE 0.0138857231714659 0.421447219412699 904 High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance aromatic amino acid transport|tryptophan transport high-affinity tryptophan transmembrane transporter activity|aromatic amino acid transmembrane transporter activity integral to membrane|plasma membrane
YHL033C RPL8A hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0138341382771104 0.423036041685362 905 Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNL178W RPS3 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME 0.013746195616644 0.42599035093841 906 Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3 cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome|DNA-(apurinic or apyrimidinic site) lyase activity preribosome, small subunit precursor|cytosolic small ribosomal subunit|90S preribosome
YMR102C_p YMR102C hom 0.0137276215280978 0.426615856728333 907 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene biological_process molecular_function cellular_component
YPR055W SEC8 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0137143003386894 0.427064793954266 908 Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress Golgi inheritance|endoplasmic reticulum inheritance|Golgi to plasma membrane transport|exocytosis|vesicle fusion|vesicle docking involved in exocytosis molecular_function incipient cellular bud site|cellular bud neck|mating projection tip|exocyst|cellular bud tip
YDR269C_d YDR269C hom 0.0136376680571889 0.429652716768396 909 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL153W RRD1 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION|NUCLEUS|CHROMOSOME 0.0135675944353377 0.432027100338767 910 Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress DNA repair|mitotic spindle organization in nucleus|G1/S transition of mitotic cell cycle|response to osmotic stress|regulation of transcription from RNA polymerase II promoter in response to stress peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity nuclear chromatin|nucleus|cytoplasm
YBR069C TAT1 hom FF|FT PLASMA MEMBRANE 0.0135650427532468 0.43314520759181 911 Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress amino acid transport|tyrosine transport|tryptophan transport|transmembrane transport amino acid transmembrane transporter activity|low-affinity tryptophan transmembrane transporter activity integral to membrane|plasma membrane
YPL269W KAR9 hom FT NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0135288204231437 0.433549972534803 912 Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase nuclear migration along microtubule|establishment of spindle localization molecular_function cell cortex|spindle pole body|mating projection tip
YOL104C NDJ1 hom FT CELL CYCLE|NUCLEUS|CHROMOSOME 0.0134668824191425 0.435452911640526 913 Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement meiotic telomere clustering|synapsis|attachment of telomeric heterochromatin to nuclear envelope|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination telomeric DNA binding nuclear chromosome, telomeric region
YMR290W-A_d YMR290W-A het FF 0.0134653675323559 0.435504561202691 914 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase Unknown Unknown Unknown
YDR200C VPS64 hom FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0133480536374847 0.439515055949573 915 Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole molecular_function endoplasmic reticulum membrane|cytoplasm
YIL154C IMP2' hom FF|FT RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS 0.0133131664821473 0.441393965583636 916 Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat DNA repair|cellular carbohydrate metabolic process transcription coactivator activity cytoplasm
YOL003C PFA4 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0132675744789983 0.442278530526085 917 Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases protein palmitoylation palmitoyltransferase activity integral to membrane|endoplasmic reticulum
YNL149C PGA2 het FT PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0132579219963545 0.442882856265796 918 Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect protein transport molecular_function nuclear envelope|endoplasmic reticulum
YLR076C_d YLR076C het 0.0132530392672834 0.444073823530825 919 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 Unknown Unknown Unknown
YGL035C MIG1 hom FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|ENDOMEMBRANE SYSTEM|NUCLEUS 0.0131314180992303 0.446976389684555 920 Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus|nuclear envelope lumen|cytoplasm
YNL131W TOM22 het FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.013047597541847 0.449882538439288 921 Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes protein import into mitochondrial matrix|protein import into mitochondrial outer membrane protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YPL186C UIP4 hom FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.0129231439638565 0.454217160553 922 Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope biological_process molecular_function mitochondrial outer membrane|nuclear envelope|endoplasmic reticulum
YFL039C ACT1 het FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MEMBRANE ORGANIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPON 0.0129228718226003 0.454226664738264 923 Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions ascospore wall assembly|vacuole inheritance|protein secretion|DNA repair|budding cell isotropic bud growth|mitochondrion inheritance|fungal-type cell wall organization|vesicle transport along actin filament|establishment of cell polarity|chronological cell aging|cytokinesis|actin filament reorganization involved in cell cycle|histone acetylation|endocytosis|exocytosis|establishment of mitotic spindle orientation|regulation of transcription from RNA polymerase II promoter|actomyosin contractile ring contraction|cellular response to oxidative stress structural constituent of cytoskeleton cellular bud neck contractile ring|actin filament|histone acetyltransferase complex|Swr1 complex|actin filament bundle|NuA4 histone acetyltransferase complex|Ino80 complex|actin cortical patch
YHR007C ERG11 het FF|FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOPLASMIC RETICULUM 0.0128625980634722 0.456334407630923 924 Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p ergosterol biosynthetic process sterol 14-demethylase activity endoplasmic reticulum
YFL025C BST1 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0127888010881578 0.459660157050351 925 GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules protein retention in ER lumen|vesicle organization|ER-associated protein catabolic process|ER to Golgi vesicle-mediated transport|GPI anchor metabolic process phosphatidylinositol deacylase activity integral to membrane|endoplasmic reticulum
YJL207C LAA1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0127363762292857 0.461301357395651 926 AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene protein localization|retrograde transport, endosome to Golgi molecular_function AP-1 adaptor complex|ribosome|clathrin-coated vesicle
YNL323W LEM3 hom FF|FT MEMBRANE ORGANIZATION|SIGNALING|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.012712247233878 0.463223385164718 927 Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane phospholipid translocation|cell surface receptor signaling pathway phospholipid-translocating ATPase activity integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YGL040C HEM2 het FT COFACTOR METABOLISM|NUCLEUS 0.0126849135970078 0.462579821001364 928 Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus heme biosynthetic process porphobilinogen synthase activity nucleus|cytoplasm
YJR090C GRR1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON|UBIQUITIN LIGASE COMPLEX 0.012599266173654 0.465607172532814 929 F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|cell cycle arrest in response to pheromone|G1/S transition of mitotic cell cycle|response to DNA damage stimulus|protein ubiquitination ubiquitin-protein ligase activity|protein binding, bridging cellular bud neck contractile ring|SCF ubiquitin ligase complex|nucleus|cytoplasm
YJR139C HOM6 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS 0.0125739382802227 0.46716981277651 930 Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process homoserine dehydrogenase activity nucleus|cytoplasm
YCR008W SAT4 hom FT PROTEIN LOCALIZATION|CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS 0.0125173308051191 0.46851358461455 931 Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p cellular cation homeostasis|protein phosphorylation|cellular protein localization|G1/S transition of mitotic cell cycle|protein dephosphorylation protein kinase activity cellular_component
YER151C UBP3 hom FT VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS 0.0121196305843224 0.482762447214891 932 Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|regulation of response to osmotic stress ubiquitin-specific protease activity|mRNA binding cytoplasm
YPL061W ALD6 hom FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|MITOCHONDRION 0.0119933449772999 0.487335765315029 933 Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress response to salt stress|NADPH regeneration|acetate biosynthetic process aldehyde dehydrogenase [NAD(P)+] activity cytosol|mitochondrion
YBR035C PDX3 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM 0.0118923041870596 0.491011636463321 934 Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism fatty acid metabolic process pyridoxamine-phosphate oxidase activity cellular_component
YJR063W RPA12 hom FF|FT NUCLEUS 0.0117622420112153 0.495765140428332 935 RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex termination of RNA polymerase I transcription|transcription of nuclear large rRNA transcript from RNA polymerase I promoter molecular_function DNA-directed RNA polymerase I complex
YGR261C APL6 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0116802954767027 0.498772677419857 936 Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools vesicle-mediated transport|Golgi to vacuole transport molecular_function AP-3 adaptor complex
YJL024C APS3 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0116788177958223 0.498826998930177 937 Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress Golgi to vacuole transport|vesicle-mediated transport molecular_function AP-3 adaptor complex
YDR007W TRP1 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0116247854979353 0.500815454690345 938 Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) tryptophan biosynthetic process phosphoribosylanthranilate isomerase activity cytoplasm
YML062C MFT1 hom FT TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION|NUCLEUS 0.0116153860058476 0.501736734635704 939 Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance mRNA export from nucleus|DNA recombination|transcription elongation from RNA polymerase II promoter protein complex scaffold|nucleic acid binding THO complex part of transcription export complex|nucleoplasmic THO complex
YNL079C TPM1 hom FF|FT VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0115539968008245 0.503426908020146 940 Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication vacuole inheritance|exocytosis|intracellular mRNA localization|filamentous growth|budding cell apical bud growth|mitochondrion inheritance|budding cell isotropic bud growth|actin polymerization or depolymerization|actin filament organization|pseudohyphal growth|vesicle-mediated transport|establishment of cell polarity|actin filament bundle assembly actin lateral binding cellular bud neck contractile ring|actin filament bundle
YIL038C NOT3 hom FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS 0.0115378082211614 0.504025126309792 941 Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of transcription elongation from RNA polymerase II promoter|protein ubiquitination ubiquitin-protein ligase activity CCR4-NOT core complex|cytoplasm
YNL271C BNI1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON 0.011482405752669 0.506202110371809 942 Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 barbed-end actin filament capping|actin nucleation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly|establishment of mitotic spindle orientation|formin-nucleated actin cable assembly profilin binding incipient cellular bud site|actin filament|polarisome|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YER177W BMH1 hom FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS 0.0114055938475647 0.508924858733999 943 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress glycogen metabolic process|pseudohyphal growth|signal transduction involved in filamentous growth|ascospore formation|fungal-type cell wall chitin biosynthetic process|Ras protein signal transduction|DNA damage checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle DNA replication origin binding|phosphoserine binding plasma membrane|nucleus
YCR093W CDC39 het FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|NUCLEUS 0.0113379376016178 0.512072060759543 944 Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor response to pheromone involved in conjugation with cellular fusion|regulation of cell cycle|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter molecular_function CCR4-NOT core complex|nucleus|cytoplasm
YER031C YPT31 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS 0.0112964561696839 0.513050947924934 945 Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication early endosome to Golgi transport|vesicle-mediated transport|exocytosis GTPase activity mitochondrial outer membrane|endosome|Golgi apparatus
YOR035C SHE4 hom FF|FT CYTOSKELETON ORGANIZATION|RNA LOCALIZATION 0.0112256808583215 0.516196102569627 946 Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization mating type switching|intracellular mRNA localization|actin cytoskeleton organization myosin binding cytoplasm
YGL188C-A_p YGL188C-A hom 0.011152922093406 0.51835755848727 947 Putative protein of unknown function biological_process molecular_function cellular_component
YLR055C SPT8 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.0111355974134952 0.519007613942027 948 Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters histone acetylation|negative regulation of transcription from RNA polymerase II promoter|chromatin modification|positive regulation of transcription from RNA polymerase II promoter TBP-class protein binding|transcription cofactor activity nucleus|SAGA complex
YHL019C APM2 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0107769902511715 0.532557123517939 949 Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YGR285C ZUO1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS|MITOCHONDRION|RIBOSOME 0.0107092468493795 0.535136670890037 950 Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p protein folding|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity unfolded protein binding mitochondrion|ribosome|nucleolus|polysome|cytoplasm
YER095W RAD51 hom FF|FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0106124573202314 0.538833135199276 951 Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein strand invasion|telomere maintenance via recombination|heteroduplex formation|meiotic joint molecule formation|reciprocal meiotic recombination|double-strand break repair via single-strand annealing recombinase activity|single-stranded DNA binding|DNA-dependent ATPase activity condensed nuclear chromosome|nuclear chromosome
YOR008C SLG1 hom FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON 0.0105939634434343 0.539722332114291 952 Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response positive regulation of endocytosis|Rho protein signal transduction|actin cytoskeleton organization|fungal-type cell wall organization|response to heat|peroxisome degradation|establishment of cell polarity|response to osmotic stress transmembrane signaling receptor activity plasma membrane|mating projection tip|cellular bud neck
YMR124W_p YMR124W hom 0.0105725597757714 0.54054178733094 953 Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization biological_process molecular_function cytoplasm
YOR349W CIN1 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS 0.0105062321018806 0.542904628505896 954 Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl protein folding|tubulin complex assembly|tubulin complex biogenesis beta-tubulin binding cellular_component
YJL014W CCT3 het FF 0.010367019705699 0.548502242340586 955 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo protein folding unfolded protein binding chaperonin-containing T-complex
YDL190C UFD2 hom FT PROTEOLYSIS|NUCLEUS 0.0103634725117435 0.548579406730338 956 Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 ER-associated protein catabolic process|protein ubiquitination|ubiquitin-dependent protein catabolic process|response to stress ubiquitin-ubiquitin ligase activity nucleus|cytoplasm
YBR241C_p YBR241C hom 0.0102752779988611 0.551809368891721 957 Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene transport|transmembrane transport substrate-specific transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|membrane
YCR077C PAT1 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|TRANSLATION|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|RIBOSOME 0.0102148048569861 0.554270959551438 958 Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|chromosome segregation|regulation of translational initiation|formation of translation preinitiation complex|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly molecular_function cytosolic small ribosomal subunit|cytoplasmic mRNA processing body
YGL025C PGD1 hom FF|FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0101380413100124 0.557428545022133 959 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex
YMR168C CEP3 het FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION|NUCLEUS|CHROMOSOME|KINETOCHORE 0.0101050544566423 0.558418149578536 960 Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain septin ring assembly|mitotic cell cycle spindle assembly checkpoint sequence-specific DNA binding|DNA binding, bending|centromeric DNA binding condensed nuclear chromosome kinetochore|CBF3 complex
YIL005W EPS1 hom FT PROTEIN LOCALIZATION|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0098984289388353 0.566491516629081 961 ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family protein retention in ER lumen|ER-associated protein catabolic process unfolded protein binding|protein disulfide isomerase activity|chaperone binding endoplasmic reticulum membrane
YNR016C ACC1 het FF|FT PROTEIN LOCALIZATION|KETONE METABOLISM|LIPID METABOLISM|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.00981422776614206 0.569797436797195 962 Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; nuclear envelope organization|protein import into nucleus|fatty acid biosynthetic process biotin carboxylase activity|acetyl-CoA carboxylase activity mitochondrion|endoplasmic reticulum membrane
YLR372W SUR4 hom FF|FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM|ENDOPLASMIC RETICULUM 0.00981195880037873 0.569886648434061 963 Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis post-Golgi vesicle-mediated transport|fatty acid elongation|fatty acid biosynthetic process|sphingolipid biosynthetic process fatty acid elongase activity integral to membrane|endoplasmic reticulum
YPL051W ARL3 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.00974176025263541 0.572650013096532 964 GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor intracellular protein transport|Golgi to plasma membrane protein transport|protein localization to organelle GTPase activity Golgi apparatus|nuclear outer membrane-endoplasmic reticulum membrane network
YHR062C RPP1 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0096214251286662 0.579280687114736 965 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing ribonuclease MRP activity|ribonuclease P activity nucleolar ribonuclease P complex|ribonuclease MRP complex
YPL145C KES1 hom FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.00957680737678995 0.579168286136742 966 One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication post-Golgi vesicle-mediated transport|positive regulation of phosphatase activity|maintenance of cell polarity|endocytosis|exocytosis|sterol transport phosphatidic acid binding|lipid binding|phosphatidylinositol-4,5-bisphosphate binding|oxysterol binding|sterol transporter activity|phosphatidylinositol-4-phosphate binding Golgi membrane|extrinsic to membrane|cytoplasm
YDL152W_d YDL152W het FF 0.00944496244483833 0.584403173921807 967 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome Unknown Unknown Unknown
YPR137W RRP9 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.00937522688562295 0.587348144014421 968 Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein rRNA modification|rRNA processing snoRNA binding box C/D snoRNP complex|small-subunit processome|nucleolus|90S preribosome
YPL251W_d YPL251W het 0.00911004178095647 0.597799129978772 969 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C Unknown Unknown Unknown
YDR435C PPM1 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS 0.00906054168898447 0.599953999059133 970 Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits cellular protein complex assembly|C-terminal protein methylation protein C-terminal leucine carboxyl O-methyltransferase activity cellular_component
YEL039C CYC7 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.00906014450531658 0.599969986757588 971 Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c electron carrier activity mitochondrion|mitochondrial intermembrane space
YLR059C REX2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.00889572827032653 0.606443601787448 972 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease U5 snRNA 3'-end processing|U4 snRNA 3'-end processing|mitochondrial genome maintenance|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 3'-5'-exoribonuclease activity|3'-5' exonuclease activity mitochondrion
YDR323C PEP7 hom FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT 0.00887749371577258 0.607181676375282 973 Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport phosphatidylinositol-3-phosphate binding external side of endosome membrane|cytoplasm
YDR361C BCP1 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.00884437610701391 0.608683559399705 974 Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport protein export from nucleus|ribosomal large subunit export from nucleus molecular_function nucleus|cytoplasm
YJR054W KCH1 hom 0.00868255062952626 0.61509724255974 975 Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate biological_process molecular_function integral to membrane|fungal-type vacuole
YDL077C VAM6 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION 0.0086825106886788 0.615098868978603 976 Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle-mediated transport|vacuole organization|vacuole fusion, non-autophagic Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding fungal-type vacuole membrane|HOPS complex|fungal-type vacuole
YCR035C RRP43 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.00859087590962112 0.618835265541302 977 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing molecular_function nucleoplasm|nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|cytoplasm
YGL155W CDC43 het FT SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS|PROTEIN PRENYLATION 0.00851704417989309 0.621852931019292 978 Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis cellular calcium ion homeostasis|protein geranylgeranylation|establishment of cell polarity|small GTPase mediated signal transduction protein geranylgeranyltransferase activity|CAAX-protein geranylgeranyltransferase activity CAAX-protein geranylgeranyltransferase complex|intracellular
YDR354W TRP4 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.00849017009907799 0.62357558466529 979 Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis tryptophan biosynthetic process anthranilate phosphoribosyltransferase activity nucleus|cytoplasm
YOR187W TUF1 hom FT TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.00825233145075569 0.6327243698946 980 Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans mitochondrial translational elongation|mitochondrial translation GTPase activity|translation elongation factor activity mitochondrion|mitochondrial matrix
YJR073C OPI3 hom FF|FT LIPID METABOLISM|MITOCHONDRION 0.00800610358253891 0.643156212791596 981 Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis phosphatidylcholine biosynthetic process phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|phosphatidyl-N-methylethanolamine N-methyltransferase activity mitochondrion|integral to membrane
YML075C HMG1 hom FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.00798560621196296 0.64400655821041 982 HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress ergosterol biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway hydroxymethylglutaryl-CoA reductase (NADPH) activity nuclear envelope|integral to membrane|endoplasmic reticulum membrane
YMR138W CIN4 hom FT SIGNALING 0.0077486210698173 0.653630171707462 983 GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog protein folding|tubulin complex assembly|tubulin complex biogenesis GTP binding cytoplasm
YBR192W RIM2 het FF|FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION 0.00770210839959375 0.655574718690152 984 Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family pyrimidine nucleotide transport|mitochondrial genome maintenance|transmembrane transport pyrimidine nucleotide transmembrane transporter activity|transporter activity mitochondrion|integral to membrane
YPL254W HFI1 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.00769362290444539 0.655929722642717 985 Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions histone acetylation|chromatin modification|transcription from RNA polymerase II promoter transcription coactivator activity|transcription cofactor activity SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YBL006C LDB7 hom FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|NUCLEUS|RSC COMPLEX 0.00750490810260413 0.663891901667149 986 Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions ATP-dependent chromatin remodeling|cell wall mannoprotein biosynthetic process|nucleosome disassembly|transcription elongation from RNA polymerase II promoter DNA translocase activity RSC complex
YDR455C_d YDR455C hom FF 0.00748084163623368 0.664856981383406 987 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W Unknown Unknown Unknown
YLL031C GPI13 het FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00730039396673729 0.672465151747827 988 ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein GPI anchor biosynthetic process mannose-ethanolamine phosphotransferase activity|transferase activity, transferring phosphorus-containing groups integral to membrane|endoplasmic reticulum
YJL008C CCT8 het 0.00711125508165766 0.680475898894685 989 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo protein folding unfolded protein binding chaperonin-containing T-complex|cytoplasm
YGR143W SKN1 hom FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 0.00708366061559619 0.681647673861299 990 Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process|sphingolipid biosynthetic process glucosidase activity integral to membrane
YGL063W PUS2 hom FT RNA PROCESSING|MITOCHONDRION 0.00708131318742991 0.681747390836635 991 Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion
YER127W LCP5 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.00696267027785108 0.68679445651327 992 Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus rRNA modification|rRNA processing RNA binding small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex
YIL106W MOB1 het FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON 0.00684223629197974 0.691932027273561 993 Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress regulation of exit from mitosis|protein phosphorylation kinase regulator activity spindle pole body|cellular bud neck
YCR098C GIT1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.00644061490638541 0.709166237693712 994 Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability transmembrane transport|glycerophosphodiester transport glycerophosphodiester transmembrane transporter activity integral to membrane|plasma membrane
YLR406C-A_p YLR406C-A hom 0.00640554849709806 0.710678233311065 995 Putative protein of unknown function biological_process molecular_function cellular_component
YJL154C VPS35 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM 0.00634254080664264 0.713397860899306 996 Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p protein retention in Golgi apparatus|retrograde transport, endosome to Golgi protein transporter activity endosome|retromer complex, inner shell|retromer complex
YPR074C TKL1 hom FF|FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS 0.00624859939252537 0.717459454163374 997 Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication pentose-phosphate shunt transketolase activity cytoplasm
YNL041C COG6 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.00598235773689493 0.729130098537792 998 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YJL034W KAR2 het FT PROTEIN LOCALIZATION|PROTEOLYSIS|ENDOPLASMIC RETICULUM 0.00594356985261609 0.730702141007025 999 ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p karyogamy involved in conjugation with cellular fusion|posttranslational protein targeting to membrane, translocation|ER-associated protein catabolic process|SRP-dependent cotranslational protein targeting to membrane, translocation|response to unfolded protein unfolded protein binding|ATPase activity endoplasmic reticulum|luminal surveillance complex
YLR399C BDF1 hom FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0059117663184443 0.732125995510346 1000 Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p DNA repair|snRNA transcription|regulation of chromatin silencing at telomere|regulation of transcription by chromatin organization|regulation of chromatin silencing at silent mating-type cassette|Unknown|chromatin remodeling|negative regulation of heterochromatin assembly histone acetyl-lysine binding|chromatin binding|core promoter binding|TFIID-class transcription factor binding nuclear chromatin|Swr1 complex
YBR268W MRPL37 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.00580626537252305 0.736727508048282 1001 Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YIL093C RSM25 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.00579766109440103 0.737065454833169 1002 Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YLR340W RPP0 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.00572847485059271 0.740650085433362 1003 Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10 translational elongation|cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome|LSU rRNA binding cytosolic large ribosomal subunit|preribosome, large subunit precursor|90S preribosome|cytoplasm
YPL074W YTA6 hom 0.00552523550374706 0.748994420788578 1004 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress biological_process ATPase activity cell cortex
YFR038W IRC5 hom FT NUCLEUS 0.00534818103817653 0.756779797219924 1005 Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci mitotic recombination molecular_function cellular_component
YBL038W MRPL16 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.00528880242964821 0.759396351498333 1006 Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome|peptidyltransferase activity mitochondrion|mitochondrial large ribosomal subunit
YFL048C EMP47 hom FT VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.00503833980156625 0.770463135091396 1007 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport ER to Golgi vesicle-mediated transport glycoprotein binding fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YNL145W MFA2 hom FT SIGNALING|PLASMA MEMBRANE 0.00499695948956233 0.772560387788974 1008 Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1 pheromone-dependent signal transduction involved in conjugation with cellular fusion mating pheromone activity extracellular region
YOR157C PUP1 het FF|FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.00496371047076924 0.774098209392525 1009 Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process endopeptidase activity proteasome storage granule|nucleus|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YNL070W TOM7 hom FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.00468390174776633 0.786203769614887 1010 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex protein import into mitochondrial matrix|protein import into mitochondrial outer membrane protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YKL133C_p YKL133C hom 0.00444938844127067 0.796667200489016 1011 Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype) biological_process molecular_function cellular_component
YML060W OGG1 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION 0.00424469128642091 0.805830333498198 1012 Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance DNA repair|base-excision repair, AP site formation oxidized purine nucleobase lesion DNA N-glycosylase activity mitochondrion
YDR429C TIF35 het FF|FT TRANSLATION 0.00422049303161808 0.806915342414848 1013 eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation translation reinitiation|translational initiation translation initiation factor activity eukaryotic translation initiation factor 3 complex
YDR187C_d YDR187C het FF 0.00400749809751707 0.816481477191772 1014 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W Unknown Unknown Unknown
YKL020C SPT23 hom FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0038699053585712 0.822753785313171 1015 ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette DNA binding integral to endoplasmic reticulum membrane|nucleus
YGR184C UBR1 hom FT PROTEOLYSIS 0.00359871036808551 0.83518383317382 1016 E3 ubiquitin ligase (N-recognin); forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; plays a major role in targeting cytosolic misfolded proteins for degradation; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS) regulation of dipeptide transport|ubiquitin-dependent protein catabolic process via the N-end rule pathway|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination ubiquitin-protein ligase activity proteasome regulatory particle, base subcomplex|cytoplasm
YDR071C PAA1 hom FT CHROMATIN ORGANIZATION 0.0035606862270413 0.836636327758153 1017 Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication chromatin organization diamine N-acetyltransferase activity|aralkylamine N-acetyltransferase activity cytoplasm
YIL048W NEO1 het FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.00354610347421106 0.837296014922588 1018 Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus retrograde vesicle-mediated transport, Golgi to ER|vacuole organization|endocytosis phospholipid-translocating ATPase activity|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism endosome|COPI-coated vesicle|integral to membrane|Golgi apparatus|Golgi membrane
YGL007W_d BRP1 hom FF 0.00351471533734257 0.838716322911157 1019 Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Unknown Unknown Unknown
YJR049C UTR1 hom FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM|NUCLEUS 0.00330236660070629 0.848338639267022 1020 ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication cellular iron ion homeostasis|NADP biosynthetic process NAD+ kinase activity|NADH kinase activity nucleus|cytoplasm
YMR260C TIF11 het FT TRANSLATION|RIBOSOME 0.00326050709485327 0.850238166444912 1021 Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 translational initiation double-stranded RNA binding|translation initiation factor activity ribosome
YLR289W GUF1 hom FT TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION|RIBOSOME 0.00288827669858196 0.867166455569323 1022 Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor positive regulation of translation ribosome binding|GTPase activity mitochondrion|mitochondrial ribosome|mitochondrial matrix
YBR020W GAL1 hom FT CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS 0.00287778565378223 0.86764448860043 1023 Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication galactose catabolic process via UDP-galactose|carbohydrate phosphorylation|positive regulation of transcription by galactose galactokinase activity cytoplasm
YBR246W RRT2 hom FT VESICLE-MEDIATED TRANSPORT 0.00252687564100992 0.883678015602117 1024 Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription peptidyl-diphthamide biosynthetic process from peptidyl-histidine|endocytic recycling molecular_function endosome|cytoplasm
YDR136C_d VPS61 hom FF 0.00249319666702803 0.885302617292759 1025 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YEL009C GCN4 hom FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.00244916397715573 0.887214398142105 1026 Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels nitrogen catabolite activation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription initiation from RNA polymerase II promoter|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels chromatin binding|TFIID-class binding transcription factor activity|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding transcription factor activity nucleus
YNR075W COS10 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0024008056902796 0.88944326119299 1027 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins endocytosis molecular_function nuclear envelope|integral to membrane|endoplasmic reticulum|cytoplasm
YDR529C QCR7 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0023591095425588 0.891335247970939 1028 Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration|mitochondrial respiratory chain complex III assembly ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YGL026C TRP5 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.0023582339864731 0.891375327605596 1029 Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis tryptophan biosynthetic process tryptophan synthase activity nucleus|cytoplasm
YDR283C GCN2 hom FF|FT KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION|RIBOSOME 0.00228215586506396 0.89490570988288 1030 Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control cellular amino acid biosynthetic process|protein phosphorylation|regulation of translational initiation|DNA damage checkpoint protein homodimerization activity|protein kinase activity|eukaryotic translation initiation factor 2alpha kinase activity cytosolic ribosome
YFR037C RSC8 het FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|RSC COMPLEX 0.00214615957813006 0.90109122037808 1031 Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters ATP-dependent chromatin remodeling|double-strand break repair via nonhomologous end joining|nucleosome disassembly|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|G1/S transition of mitotic cell cycle DNA translocase activity|DNA binding RSC complex|nucleus
YDR035W ARO3 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS|MITOCHONDRION 0.00213004566287495 0.9019174982733 1032 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan aromatic amino acid family biosynthetic process 3-deoxy-7-phosphoheptulonate synthase activity mitochondrion|nucleus|cytoplasm
YNL221C POP1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.00196832435672124 0.909290413255247 1033 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing ribonuclease MRP activity|ribonuclease P activity nucleolar ribonuclease P complex|ribonuclease MRP complex
YLR163C MAS1 het FF|FT PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.00189827555514907 0.912570432071786 1034 Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins protein processing involved in protein targeting to mitochondrion metalloendopeptidase activity mitochondrion|mitochondrial processing peptidase complex
YML007C-A_p YML007C-A hom FF|FT MITOCHONDRION 0.00188025206808928 0.913294189151449 1035 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria biological_process molecular_function mitochondrion
YEL012W UBC8 hom FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS 0.00187822458535079 0.913387316203086 1036 Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination ubiquitin-protein ligase activity cytoplasm
YBR171W SEC66 hom FF|FT PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00187725671254309 0.913470351168125 1037 Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation|filamentous growth protein transporter activity integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YPL149W ATG5 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.00183111416544589 0.915551540682298 1038 Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation C-terminal protein lipidation|mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy|CVT pathway Atg8 ligase activity cytosol|Atg12-Atg5-Atg16 complex|pre-autophagosomal structure|autophagic vacuole
YGL084C GUP1 hom FF|FT LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.00180057637246114 0.916954763957554 1039 Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport GPI anchor biosynthetic process|glycerol transport|glycerol catabolic process O-acyltransferase activity integral to membrane|endoplasmic reticulum|plasma membrane|membrane
YHR170W NMD3 het FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS|RIBOSOME 0.00179059483945418 0.91756084184333 1040 Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex ribosomal large subunit export from nucleus ribosomal large subunit binding cytosol|cytosolic large ribosomal subunit
YFR009W GCN20 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEOTIDE METABOLISM|RIBOSOME 0.00177919469255043 0.91799839817228 1041 Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA regulation of translational elongation ATPase activity cytosol|cytosolic ribosome
YLR110C CCW12 hom FF|FT CELL WALL ORG/BIOGENESIS|SITE OF POLARIZED GROWTH 0.00175628893275598 0.919026365728301 1042 Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication conjugation with cellular fusion|agglutination involved in conjugation with cellular fusion|fungal-type cell wall organization molecular_function fungal-type cell wall|mating projection tip|cellular bud tip
YGL072C_d YGL072C hom FF 0.00173571708091128 0.919935925904406 1043 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 Unknown Unknown Unknown
YBR015C MNN2 hom FF|FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0016584653129856 0.923488154542564 1044 Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment protein glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YJL120W_d YJL120W hom FF 0.00164059428400492 0.924310128842656 1045 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YFR036W CDC26 hom FF|FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.00163480567145592 0.924576392249325 1046 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YDL066W IDP1 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.00162531742180825 0.925012849055505 1047 Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes isocitrate metabolic process|glutamate biosynthetic process isocitrate dehydrogenase (NADP+) activity mitochondrial nucleoid|mitochondrion
YOR273C TPO4 hom FF|FT PLASMA MEMBRANE 0.0016037075085492 0.926006982970266 1048 Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane spermidine transport|spermine transport spermidine transmembrane transporter activity|spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|plasma membrane
YGL054C ERV14 hom FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.00158781978732204 0.926857865620009 1049 COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication ascospore formation|ER to Golgi vesicle-mediated transport|axial cellular bud site selection molecular_function integral to membrane|ER to Golgi transport vesicle|endoplasmic reticulum membrane
YHR142W CHS7 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00158770672443376 0.926808530948719 1050 Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress protein folding|ER to Golgi vesicle-mediated transport|fungal-type cell wall chitin biosynthetic process unfolded protein binding integral to membrane|endoplasmic reticulum membrane
YBL105C PKC1 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.00157462956573884 0.927398889171916 1051 Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) intracellular protein kinase cascade|regulation of nuclear-transcribed mRNA poly(A) tail shortening|fungal-type cell wall organization|signal transduction|actin filament organization|peroxisome degradation|protein phosphorylation|cytoplasmic mRNA processing body assembly protein kinase C activity site of polarized growth|cytoskeleton|nucleus|plasma membrane|cytoplasm
YKL195W MIA40 het FF|FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.00156978666002128 0.92762156583996 1052 Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p protein import into mitochondrial intermembrane space molecular_function mitochondrion|mitochondrial inner membrane|mitochondrial outer membrane translocase complex|mitochondrial intermembrane space
YKL165C MCD4 het FF|FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.00156907814473307 0.927600298725264 1053 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes GPI anchor biosynthetic process|ATP transport mannose-ethanolamine phosphotransferase activity integral to membrane|fungal-type cell wall|endoplasmic reticulum|fungal-type vacuole
YHL011C PRS3 hom FF|FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 0.001562724816986 0.92789265046598 1054 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process|regulation of cell size ribose phosphate diphosphokinase activity cytoplasm
YOR277C_d YOR277C hom 0.00155797844568986 0.928111063606332 1055 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 Unknown Unknown Unknown
YLR111W_d YLR111W hom FF 0.00155509216939236 0.928243883649236 1056 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR203W_d YDR203W hom FF 0.0015484085019751 0.92857271070401 1057 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR264W CUE1 hom FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|UBIQUITIN LIGASE COMPLEX 0.00152423263943179 0.929664095031687 1058 Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication ER-associated protein catabolic process|establishment of protein localization to endoplasmic reticulum membrane ubiquitin-protein ligase activator activity Doa10p ubiquitin ligase complex|mitochondrion|integral to endoplasmic reticulum membrane
YMR154C RIM13 hom FF|FT ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS 0.0015159852705098 0.930158226012945 1059 Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB protein processing cysteine-type endopeptidase activity cellular_component
YOR244W ESA1 het FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.0015147610556533 0.93010003957081 1060 Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy DNA repair|histone acetylation|regulation of cell cycle|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|chromatin silencing at rDNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter H4 histone acetyltransferase activity|histone acetyltransferase activity Piccolo NuA4 histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YLR321C SFH1 het FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|RSC COMPLEX 0.00150379829275105 0.930614965494773 1061 Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog ATP-dependent chromatin remodeling|double-strand break repair|chromosome segregation|regulation of DNA replication involved in S phase|chromatin remodeling at centromere|nucleosome disassembly|G2/M transition of mitotic cell cycle|transcription elongation from RNA polymerase II promoter DNA translocase activity RSC complex
YMR071C TVP18 hom FF|FT VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.00150172952147614 0.930730797095157 1062 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments vesicle-mediated transport molecular_function integral to membrane|integral to Golgi membrane|clathrin-coated vesicle
YNL099C OCA1 hom FF|FT RESPONSE TO OXIDATIVE STRESS 0.00148555255845246 0.931444538039394 1063 Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA cellular response to oxidative stress protein tyrosine phosphatase activity cytoplasm
YLR417W VPS36 hom FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.00148516759122199 0.931492847698589 1064 Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome negative regulation of transcription from RNA polymerase II promoter by glucose|protein retention in Golgi apparatus|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole ubiquitin binding ESCRT II complex
YER107C GLE2 hom FF|FT PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.00146691762231538 0.932302426573869 1065 RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 poly(A)+ mRNA export from nucleus|Unknown|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear pore distribution|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery molecular_function integral to membrane|nuclear pore|cytoplasm
YBL106C SRO77 hom FF|FT VESICLE-MEDIATED TRANSPORT|PLASMA MEMBRANE 0.00146637232871413 0.932327531209352 1066 Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication exocytosis|Golgi to plasma membrane transport molecular_function plasma membrane
YGR122W YGR122W hom FF|FT TRANSCRIPTION FROM RNA POL II 0.0014414152130418 0.933476597222267 1067 Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function cytoplasm
YBR006W UGA2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS 0.00143966815784518 0.933566924009919 1068 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm cellular response to oxidative stress|gamma-aminobutyric acid catabolic process|glutamate decarboxylation to succinate succinate-semialdehyde dehydrogenase [NAD(P)+] activity cytoplasm
YLR418C CDC73 hom FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|CHROMOSOME|RNA POL II, HOLOENZYME 0.00142061700738871 0.934434286239652 1069 Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress transcription elongation from RNA polymerase I promoter|negative regulation of DNA recombination|mRNA 3'-end processing|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair|transcription elongation from RNA polymerase II promoter chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YMR242C RPL20A hom FF|FT TRANSLATION|RIBOSOME 0.0014135818829385 0.934767958568683 1070 Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YAL009W SPO7 hom FF|FT CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.00140970165098844 0.934946620535085 1071 Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation negative regulation of phospholipid biosynthetic process|nuclear envelope organization phosphoprotein phosphatase activity Nem1-Spo7 phosphatase complex|integral to membrane
YNL093W YPT53 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT|PLASMA MEMBRANE 0.00140835262075201 0.934999065484496 1072 Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication endocytosis|protein targeting to vacuole GTPase activity late endosome
YPL241C CIN2 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON 0.00140428568264852 0.935186356623884 1073 GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 protein folding|tubulin complex assembly|tubulin complex biogenesis GTPase activator activity cellular_component
YBR004C GPI18 het FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.00140395169347016 0.935201737694524 1074 Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria GPI anchor biosynthetic process mannosyltransferase activity|dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity integral to endoplasmic reticulum membrane|mitochondrion|mannosyltransferase complex|integral to membrane|endoplasmic reticulum
YGR056W RSC1 hom FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|RSC COMPLEX 0.00139773400360164 0.935488082898411 1075 Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook double-strand break repair|ATP-dependent chromatin remodeling|regulation of sporulation resulting in formation of a cellular spore|double-strand break repair via nonhomologous end joining|nucleosome disassembly|transcription elongation from RNA polymerase II promoter DNA-dependent ATPase activity RSC complex
YBL061C SKT5 hom FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON 0.00139435962313297 0.935643487785188 1076 Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication fungal-type cell wall chitin biosynthetic process|response to osmotic stress|cytokinesis enzyme activator activity incipient cellular bud site|cellular bud neck septin ring|cellular bud neck
YNL084C END3 hom FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON 0.00138809923209757 0.935931812489508 1077 EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p bipolar cellular bud site selection|ascospore wall assembly|endocytosis|actin filament organization|cytokinesis|actin cortical patch assembly protein binding, bridging mating projection tip|actin cortical patch
YGL020C GET1 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS 0.00138492796812943 0.936077869472039 1078 Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane protein anchor mitochondrion|integral to membrane|endoplasmic reticulum|GET complex
YIL002C INP51 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|CYTOSKELETON 0.00138336141772294 0.936159520195197 1079 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth phosphatidylinositol dephosphorylation phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity membrane|cytoplasm
YMR032W HOF1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.00138176707271406 0.936223451056145 1080 Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p cytokinesis after mitosis|barrier septum assembly involved in cell cycle cytokinesis|response to DNA damage stimulus|cytokinesis cytoskeletal protein binding cellular bud neck contractile ring|cellular bud neck septin ring
YMR211W DML1 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.00137755766536853 0.93641732733682 1081 Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family plasmid maintenance|mitochondrial genome maintenance molecular_function mitochondrion|cytoplasm
YDL160C DHH1 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|RNA LOCALIZATION 0.00137530690766053 0.936530439263973 1082 Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|cell morphogenesis involved in conjugation with cellular fusion|stress granule assembly|cytoplasmic mRNA processing body assembly protein binding|RNA helicase activity cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YDR011W SNQ2 hom FF|FT NUCLEOTIDE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE 0.00137199793385833 0.936673402428284 1083 Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species response to drug xenobiotic-transporting ATPase activity mitochondrion|integral to membrane|plasma membrane
YHR004C NEM1 hom FF|FT LIPID METABOLISM|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.00137171691903085 0.936761751898853 1084 Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard negative regulation of phospholipid biosynthetic process|nuclear envelope organization phosphoprotein phosphatase activity Nem1-Spo7 phosphatase complex|mitochondrion|integral to membrane
YFL023W BUD27 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RIBOSOME 0.00136712757019786 0.936982287514092 1085 Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP formation of translation preinitiation complex molecular_function cytosolic ribosome|cytoplasm
YFL002C SPB4 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.00136541846727513 0.936976453847792 1086 Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients ribosomal large subunit assembly|rRNA processing ATP-dependent RNA helicase activity nucleolus|90S preribosome
YBR021W FUR4 hom FF|FT PLASMA MEMBRANE 0.00135594294686615 0.937459493748103 1087 Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation uracil transport|transmembrane transport uracil:cation symporter activity integral to membrane|membrane raft|plasma membrane
YCR026C NPP1 hom FT NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS 0.00135285674052481 0.937555074559535 1088 Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication cellular response to phosphate starvation|phosphate-containing compound metabolic process|nucleoside triphosphate metabolic process nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity cellular_component
YPR198W SGE1 hom FF|FT PLASMA MEMBRANE 0.00135078369056965 0.937696970515917 1089 Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations response to drug|drug transport drug transmembrane transporter activity integral to membrane|integral to plasma membrane
YDR372C VPS74 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS 0.00134679682367535 0.93788048685824 1090 Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33 retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum unfolded protein response|protein localization to Golgi apparatus enzyme binding|phosphatidylinositol-4-phosphate binding cytosol|Golgi apparatus|nucleus|extrinsic to membrane|cytoplasm
YHR017W YSC83 hom FT MITOCHONDRION 0.00133094027302148 0.938592105355523 1091 Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 biological_process molecular_function mitochondrial outer membrane|mitochondrion
YNL294C RIM21 hom FF|FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.00133046839612522 0.938586412381338 1092 pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH fungal-type cell wall biogenesis|ascospore formation|invasive growth in response to glucose limitation molecular_function integral to membrane
YEL034W HYP2 het FF|FT KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION|RIBOSOME 0.00132493882425949 0.93886846114473 1093 Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication positive regulation of translational initiation|translational frameshifting|positive regulation of translational termination|positive regulation of translational elongation ribosome binding|RNA binding|translation elongation factor activity|translation initiation factor activity mitochondrion|cytosolic ribosome|cytoplasm
YPL161C BEM4 hom FF|FT SIGNALING|CYTOSKELETON ORGANIZATION|NUCLEUS 0.00132445474067449 0.938863454069688 1094 Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length establishment of cell polarity|Rho protein signal transduction|actin cytoskeleton organization molecular_function nucleus|cytoplasm
YMR001C-A_p YMR001C-A hom 0.00132110668164389 0.93901769822663 1095 Putative protein of unknown function biological_process molecular_function cellular_component
YDR172W SUP35 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEOTIDE METABOLISM 0.00131784703146919 0.93916787160911 1096 Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype translational termination|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay translation release factor activity cytosol|translation release factor complex
YDR076W RAD55 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS 0.00131154451139905 0.939458237347999 1097 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p DNA recombinase assembly|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|protein heterodimerization activity nucleus|Rhp55-Rhp57 complex
YML094C-A_d YML094C-A hom FF 0.00130917085812916 0.939567596895573 1098 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YDL119C_p YDL119C hom FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION 0.00130379252109305 0.939815393197261 1099 Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria transport transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YOR089C VPS21 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT|MITOCHONDRION 0.00130330793201849 0.939837719972253 1100 Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication endocytosis|vacuole inheritance|protein targeting to vacuole GTP binding|GTPase activity mitochondrial outer membrane|late endosome|mitochondrion
YNL170W_d YNL170W hom 0.00130102208764115 0.939943037744492 1101 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR004W RAD57 hom FF|FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS 0.00129665813963393 0.940144104775808 1102 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p DNA recombinase assembly|telomere maintenance via recombination|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|protein heterodimerization activity nucleus|Rhp55-Rhp57 complex
YOR207C RET1 het FF|FT NUCLEUS 0.00129630770042977 0.940160251277318 1103 Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YMR077C VPS20 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT 0.00128995593357223 0.940479504987317 1104 Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport protein binding ESCRT III complex|cytoplasm
YJR118C ILM1 hom FF|FT MITOCHONDRION ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00128811318562809 0.940537820897087 1105 Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth mitochondrial genome maintenance molecular_function integral to membrane|endoplasmic reticulum
YLR200W YKE2 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEUS 0.00128378495350884 0.940737253471299 1106 Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin protein folding|tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YDL147W RPN5 het FT PROTEOLYSIS|NUCLEUS 0.00128314695866672 0.940766650765872 1107 Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein cullin deneddylation|ubiquitin-dependent protein catabolic process molecular_function proteasome complex|signalosome|proteasome storage granule|proteasome regulatory particle, lid subcomplex
YOR198C BFR1 hom FT CELL CYCLE|ENDOMEMBRANE SYSTEM 0.00128142940849739 0.940845791819442 1108 Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity meiosis|mRNA metabolic process|regulation of mitosis RNA binding ribonucleoprotein complex|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YPL066W RGL1 hom FF|FT SITE OF POLARIZED GROWTH 0.00128038222650837 0.940894044021648 1109 Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source protein localization to bud neck molecular_function cellular bud neck|cytoplasm
YHR107C CDC12 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.00127413897399553 0.94126932952745 1110 Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells maintenance of cell polarity|cell cycle cytokinesis|positive regulation of protein kinase activity|septin ring assembly protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding septin filament array|cellular bud neck septin ring|septin complex|cytoplasm|mating projection
YBL046W PSY4 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS 0.00127053079006108 0.941347990518555 1111 Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2 Unknown|protein dephosphorylation protein phosphatase regulator activity nucleus|cytoplasm
YMR263W SAP30 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0012665669989657 0.941539346989984 1112 Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase II promoter histone deacetylase activity histone deacetylase complex|Rpd3L-Expanded complex|Rpd3L complex
YJL053W PEP8 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM 0.00126357265524051 0.941668627421889 1113 Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress protein retention in Golgi apparatus|retrograde transport, endosome to Golgi protein transporter activity endosome|retromer complex, inner shell|retromer complex
YER119C-A_d YER119C-A hom FF 0.00125677249389828 0.941981993900663 1114 Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2 Unknown Unknown Unknown
YBR023C CHS3 hom FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH 0.0012472426947734 0.942421163222074 1115 Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan ascospore wall assembly|fungal-type cell wall chitin biosynthetic process|cytokinesis chitin synthase activity incipient cellular bud site|integral to membrane|chitosome|prospore membrane|cellular bud neck|mating projection tip|cytoplasm
YCR017C CWH43 hom FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.00124624260005949 0.942467252399916 1116 Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion fungal-type cell wall organization|GPI anchor biosynthetic process molecular_function integral to membrane|integral to plasma membrane|cellular bud neck|cellular bud tip
YHR161C YAP1801 hom FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON 0.00124479893896673 0.942533783590919 1117 Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication endocytosis clathrin binding actin cortical patch
YBL031W SHE1 hom FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.001243365961274 0.942608366943023 1118 Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function mitotic spindle elongation molecular_function microtubule cytoskeleton|nuclear microtubule|cellular bud neck|astral microtubule|spindle
YDR432W NPL3 hom FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|NUCLEUS 0.00124105411049749 0.942783166884406 1119 RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress translational termination|mRNA export from nucleus|negative regulation of translation|mRNA splicing, via spliceosome|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter mRNA binding|RNA polymerase II core binding|eukaryotic initiation factor 4G binding|poly(A) RNA binding nucleus|cytoplasm
YDL006W PTC1 hom FF|FT RNA PROCESSING|SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS 0.00124064103712781 0.942819253625103 1120 Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation mitochondrion inheritance|inactivation of MAPK activity involved in osmosensory signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|tRNA splicing, via endonucleolytic cleavage and ligation|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YIL026C IRR1 het FF|FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0012381538760317 0.942882581949004 1121 Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability spore germination|fungal-type cell wall organization|cytogamy|mitotic sister chromatid cohesion chromatin binding nucleus|nuclear mitotic cohesin complex
YOR275C RIM20 hom FT ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS|NUCLEUS 0.00123691959513559 0.9428969105817 1122 Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation proteolysis|response to pH|protein processing|invasive growth in response to glucose limitation|sporulation resulting in formation of a cellular spore molecular_function nucleus|cytoplasm
YBR136W MEC1 het FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|MITOCHONDRION 0.00123447628021116 0.943009515467281 1123 Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres histone phosphorylation|telomere maintenance via recombination|telomere maintenance|nucleobase-containing compound metabolic process|reciprocal meiotic recombination|DNA recombination|DNA damage checkpoint|DNA replication|DNA damage induced protein phosphorylation protein kinase activity mitochondrion|nucleus
YMR245W_d YMR245W hom 0.00123308736556927 0.943073526787795 1124 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR535C_d YDR535C hom 0.00123162197810223 0.943141062932432 1125 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. Unknown Unknown Unknown
YDR439W LRS4 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME|KINETOCHORE 0.00123091315639574 0.943173730947724 1126 Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation rDNA condensation|chromatin silencing at rDNA|homologous chromosome segregation|protein localization to nucleolar rDNA repeats molecular_function nucleolus|nucleus|monopolin complex
YDL115C IWR1 hom FT PROTEIN LOCALIZATION|NUCLEUS|RNA POL II, HOLOENZYME 0.00123027620698492 0.94320308661033 1127 RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress cellular protein complex localization|nucleocytoplasmic transport protein binding nucleus|DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YDR079C-A TFB5 hom FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME 0.00122979817026502 0.943225118370919 1128 Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity core TFIIH complex|holo TFIIH complex|nucleus
YML115C VAN1 hom FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.00122678885008808 0.943363812942186 1129 Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant protein N-linked glycosylation alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YDR158W HOM2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS 0.00122632073742665 0.943486602022303 1130 Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis methionine biosynthetic process|threonine biosynthetic process|homoserine biosynthetic process aspartate-semialdehyde dehydrogenase activity nucleus|plasma membrane|cytoplasm
YMR237W BCH1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|GOLGI APPARATUS 0.00122571652283835 0.943413235139966 1131 Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process molecular_function ribosome|clathrin-coated vesicle|exomer complex
YHR179W OYE2 hom FT OXIDATION-REDUCTION PROCESS|NUCLEUS|MITOCHONDRION 0.00122566697473911 0.943415518754045 1132 Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress apoptotic process NADPH dehydrogenase activity mitochondrion|nucleus|cytoplasm
YOR188W MSB1 hom FT MITOCHONDRION|SITE OF POLARIZED GROWTH 0.00122561202296615 0.943418051417686 1133 Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress establishment of cell polarity molecular_function mitochondrion|cellular bud neck|cellular bud tip
YHR129C ARP1 hom FT CELL CYCLE|CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.00122091600613558 0.943634487509953 1134 Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin nuclear migration|establishment of mitotic spindle orientation structural constituent of cytoskeleton cell cortex|dynactin complex|spindle pole body|astral microtubule
YIL034C CAP2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.00121828646938972 0.943755682815326 1135 Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress barbed-end actin filament capping|filamentous growth actin filament binding actin filament|F-actin capping protein complex|mating projection tip|actin cortical patch
YDL041W_d YDL041W hom FF 0.00121785055848871 0.943775774067414 1136 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C Unknown Unknown Unknown
YHR012W VPS29 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM 0.00121774240587132 0.943780758856526 1137 Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval retrograde transport, endosome to Golgi protein transporter activity endosome|retromer complex, inner shell|retromer complex
YKR097W PCK1 hom FT CARBOHYDRATE METABOLISM 0.00121296889967437 0.944000773490141 1138 Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol gluconeogenesis phosphoenolpyruvate carboxykinase (ATP) activity cytosol
YKR073C_d YKR073C hom 0.00121200743021693 0.944045088886531 1139 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIR031C DAL7 hom FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM 0.00120449491977053 0.944432760360113 1140 Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin catabolic process malate synthase activity cellular_component
YER007W PAC2 hom FT CYTOSKELETON 0.00120398904532154 0.94442294841649 1141 Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl protein folding|tubulin complex assembly|tubulin complex biogenesis alpha-tubulin binding cellular_component
YDR369C XRS2 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS 0.00120236122023946 0.944489704994441 1142 Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling double-strand break repair via nonhomologous end joining|meiotic DNA double-strand break formation|base-excision repair|telomere maintenance|sporulation resulting in formation of a cellular spore|double-strand break repair via break-induced replication single-stranded telomeric DNA binding|protein binding, bridging|DNA binding|double-stranded telomeric DNA binding|telomeric DNA binding|G-quadruplex DNA binding nucleus|Mre11 complex
YBR279W PAF1 hom FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING|NUCLEUS|CHROMOSOME|RNA POL II, HOLOENZYME 0.00119849974363788 0.944667694226531 1143 Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1 negative regulation of DNA recombination|mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of transcription-coupled nucleotide-excision repair|rRNA processing|transcription elongation from RNA polymerase I promoter|regulation of chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin silencing at rDNA|Unknown|snoRNA 3'-end processing|transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YBR013C_p YBR013C hom 0.00119765207377655 0.94470676672434 1144 Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein biological_process molecular_function cellular_component
YBL079W NUP170 hom FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0011936846063018 0.944914261769863 1145 Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication nucleocytoplasmic transport|chromosome segregation|protein targeting to nuclear inner membrane|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore inner ring
YIL052C RPL34B hom FF|FT TRANSLATION|RIBOSOME 0.00118674000138727 0.945209759670277 1146 Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR212W TCP1 het 0.00116972368777267 0.945994171655093 1147 Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein protein folding unfolded protein binding plasma membrane|chaperonin-containing T-complex
YPR134W MSS18 hom FT RNA PROCESSING|MITOCHONDRION 0.00116931441374222 0.946021076523908 1148 Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions Group I intron splicing molecular_function mitochondrion
YCR065W HCM1 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|CHROMOSOME 0.00116797458291649 0.946082832733748 1149 Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role positive regulation of transcription involved in S-phase of mitotic cell cycle|cellular response to oxidative stress|mitochondrion organization|spindle pole body organization|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nuclear chromatin|nucleus|cytoplasm
YKR007W MEH1 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS 0.00116194098385747 0.946392901432505 1150 Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification microautophagy|vacuolar acidification molecular_function fungal-type vacuole membrane|EGO complex|late endosome membrane
YMR052W FAR3 hom FT CELL CYCLE|SIGNALING|ENDOPLASMIC RETICULUM 0.00116146755925391 0.94637477864087 1151 Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress re-entry into mitotic cell cycle after pheromone arrest molecular_function endoplasmic reticulum
YPL120W VPS30 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION 0.00116079396901084 0.946413810997893 1152 Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1 phosphatidylinositol biosynthetic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|retrograde transport, endosome to Golgi|macroautophagy|CVT pathway|late endosome to vacuole transport 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|extrinsic to membrane|cytoplasm
YDR080W VPS41 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING 0.00116058357293889 0.946415531078895 1153 Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole organization|vesicle-mediated transport|protein transport|vacuole fusion, non-autophagic|vacuolar protein processing Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding endosome|fungal-type vacuole membrane|HOPS complex
YPL229W_p YPL229W hom 0.00115891350312858 0.946492522943283 1154 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YJL192C SOP4 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00115772882433911 0.946547138106053 1155 ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum
YBR281C DUG2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS|NUCLEUS 0.00115583637441932 0.946634382917315 1156 Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) glutathione catabolic process peptidase activity|gamma-glutamyltransferase activity|omega peptidase activity nucleus|cytoplasm
YDR462W MRPL28 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.00115462632686837 0.94669016827983 1157 Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YLR171W_d YLR171W hom 0.00115370926167215 0.946780049841236 1158 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL181W CTI6 hom FT CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.00115332057574903 0.946758294248792 1159 Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription, DNA-dependent|regulation of DNA-dependent DNA replication initiation|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA methylated histone residue binding|transcription factor binding Rpd3L-Expanded complex|nucleus|Rpd3L complex
YPL115C BEM3 hom FT SIGNALING|SITE OF POLARIZED GROWTH 0.00115231947159713 0.946796519169119 1160 Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly negative regulation of Rho protein signal transduction|establishment of cell polarity Rho GTPase activator activity|phosphatidylinositol-3-phosphate binding cell cortex|incipient cellular bud site|mating projection tip|cytoplasm|cellular bud tip
YER003C PMI40 het FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEUS 0.00115226189952952 0.946799173374887 1161 Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation protein glycosylation|cell wall mannoprotein biosynthetic process|GDP-mannose biosynthetic process mannose-6-phosphate isomerase activity nucleus|cytoplasm
YBL098W BNA4 hom FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|MITOCHONDRION 0.00115082755145329 0.946865300336438 1162 Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease de novo NAD biosynthetic process from tryptophan kynurenine 3-monooxygenase activity mitochondrial outer membrane|mitochondrion
YPL049C DIG1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.00114951834287498 0.946925658379858 1163 MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown DNA binding|transcription factor binding nucleus
YHR036W BRL1 het FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.00114826459972657 0.946983459602909 1164 Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export mRNA export from nucleus|protein export from nucleus|nuclear envelope organization molecular_function nuclear envelope|endoplasmic reticulum
YML037C_p YML037C hom 0.00114672414114286 0.947062362689492 1165 Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene biological_process molecular_function clathrin-coated vesicle
YKL033W-A_p YKL033W-A hom 0.00114555715822236 0.947108281519562 1166 Putative protein of unknown function; similar to uncharacterized proteins from other fungi biological_process molecular_function cellular_component
YBR103W SIF2 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|GENE SILENCING|NUCLEUS|CHROMOSOME 0.00114497122073655 0.94713529532675 1167 WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus negative regulation of meiosis|negative regulation of chromatin silencing at telomere|regulation of transcription, DNA-dependent|histone deacetylation|positive regulation of stress-activated MAPK cascade molecular_function Rpd3L-Expanded complex|nucleus|Set3 complex
YHR202W_p YHR202W hom FT NUCLEOTIDE METABOLISM 0.00114468313310109 0.947148577216166 1168 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization biological_process molecular_function cytosol|fungal-type vacuole
YNL059C ARP5 hom FT CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.00114462953239586 0.947151048405549 1169 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes nucleosome mobilization|chromatin remodeling ATP-dependent 3'-5' DNA helicase activity nucleus|Ino80 complex
YOR136W IDH2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.00114288757977618 0.947231359095906 1170 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated glutamate biosynthetic process|isocitrate metabolic process|tricarboxylic acid cycle isocitrate dehydrogenase (NAD+) activity mitochondrial isocitrate dehydrogenase complex (NAD+)|mitochondrion|mitochondrial matrix
YNR064C YNR064C hom 0.00113770700291289 0.94747020670349 1171 Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides response to toxin epoxide hydrolase activity cellular_component
YDR527W RBA50 het FF|FT TRANSCRIPTION FROM RNA POL II 0.00113600606246666 0.947548628644385 1172 Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 transcription from RNA polymerase II promoter molecular_function cytoplasm
YHR198C AIM18 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION 0.00113466375162298 0.94761051630887 1173 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YHR204W MNL1 hom FT PROTEOLYSIS|ENDOPLASMIC RETICULUM 0.00113453279104636 0.947616554304452 1174 Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation ER-associated protein catabolic process carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity endoplasmic reticulum lumen
YKL101W HSL1 hom FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.00113386583101611 0.947647304839676 1175 Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p G2/M transition of mitotic cell cycle|regulation of cell cycle|cell shape checkpoint|protein autophosphorylation|protein phosphorylation|septin checkpoint protein kinase activity cellular bud neck|septin ring
YJL037W IRC18 hom 0.00113372911878211 0.947653608037166 1176 Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YBL012C_d YBL012C hom 0.00113350050833748 0.947664148262711 1177 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR423C ATG17 hom FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION 0.00113300616461055 0.947686940316428 1178 Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|activation of protein kinase activity|autophagic vacuole assembly protein kinase activator activity|protein complex scaffold pre-autophagosomal structure|Atg1p signaling complex
YDR524W-C_p YDR524W-C hom 0.00113209520104552 0.947767867345005 1179 Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin biological_process molecular_function cellular_component
YOR133W EFT1 hom FT TRANSLATION|NUCLEOTIDE METABOLISM|RIBOSOME 0.00113098849640058 0.947779966724944 1180 Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication translational elongation translation elongation factor activity ribosome
YLR338W_d OPI9 hom FF 0.00113000084386615 0.947825503593318 1181 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C Unknown Unknown Unknown
YPL157W TGS1 hom FT CELL CYCLE|RNA PROCESSING|NUCLEUS 0.00112802062555663 0.947916804373772 1182 Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs meiosis|RNA methylation|nucleologenesis|7-methylguanosine cap hypermethylation|regulation of telomere maintenance via telomerase RNA methyltransferase activity nucleolus
YGR240C PFK1 hom FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0011278488351159 0.947947990123713 1183 Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes proton transport|glycolysis 6-phosphofructokinase activity mitochondrion|6-phosphofructokinase complex|cytoplasm
YMR311C GLC8 hom FT SIGNALING|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION|NUCLEUS 0.00112767634455013 0.947932678008836 1184 Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress chromosome segregation|glycogen biosynthetic process enzyme activator activity nucleus|cytoplasm
YBR291C CTP1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION 0.00112742323460525 0.94794434806718 1185 Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family mitochondrial citrate transport|transmembrane transport tricarboxylate secondary active transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YKL098W MTC2 hom 0.00112663948755766 0.948019223640111 1186 Protein of unknown function; mtc2 is synthetically sick with cdc13-1 biological_process molecular_function cellular_component
YLR386W VAC14 hom FT PROTEIN LOCALIZATION|LIPID METABOLISM 0.00112387711133036 0.948107849198404 1187 Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p phosphatidylinositol biosynthetic process|positive regulation of kinase activity protein binding, bridging fungal-type vacuole membrane|PAS complex|extrinsic to vacuolar membrane
YPR173C VPS4 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM 0.00112255212729902 0.948168940807525 1188 AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport ATPase activity|protein homodimerization activity|ATP binding endosome|endoplasmic reticulum|membrane|cytoplasm
YPR047W MSF1 hom FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0011220188915325 0.948193527024537 1189 Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase phenylalanyl-tRNA aminoacylation|mitochondrial phenylalanyl-tRNA aminoacylation phenylalanine-tRNA ligase activity mitochondrion
YCR002C CDC10 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.00112142817752814 0.948220763482239 1190 Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress sporulation|maintenance of cell polarity|exit from mitosis|cell cycle cytokinesis|septin ring assembly protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding spindle microtubule|ascospore-type prospore|septin complex|prospore membrane|mating projection base|meiotic spindle|septin filament array|cellular bud neck septin ring|mating projection tip
YJR060W CBF1 hom FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CHROMOSOME|KINETOCHORE 0.00112041427900847 0.948267512141005 1191 Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress regulation of transcription from RNA polymerase II promoter in response to methionine|negative regulation of transcription from RNA polymerase II promoter|methionine biosynthetic process|chromosome segregation|Unknown|chromatin remodeling|negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II repressing transcription factor binding|centromeric DNA binding chromosome, centromeric region|mitochondrion|nucleus|kinetochore
YGL223C COG1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.00112019661933488 0.948331482561719 1192 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YCR045C RRT12 hom FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS 0.00111852092044728 0.94836250127368 1193 Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores ascospore wall assembly serine-type peptidase activity nuclear envelope|ascospore wall
YLR172C DPH5 hom 0.0011178481205629 0.948408892578809 1194 Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm peptidyl-diphthamide biosynthetic process from peptidyl-histidine diphthine synthase activity cytoplasm
YGR242W_d YGR242W hom 0.00111781008821147 0.948387586538305 1195 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C Unknown Unknown Unknown
YPR040W TIP41 hom FT SIGNALING|NUCLEUS 0.00111670347701517 0.948438610678611 1196 Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress signal transduction molecular_function nucleus|cytoplasm
YDR448W ADA2 hom FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.00111437264386844 0.948546082501379 1197 Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes chromatin silencing at rDNA|chromatin modification|regulation of transcription from RNA polymerase II promoter|positive regulation of histone acetylation|chromatin silencing at telomere chromatin binding|transcription coactivator activity|histone acetyltransferase activity|phosphatidylserine binding SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YHR154W RTT107 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.00111383725029897 0.948570768966422 1198 Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress negative regulation of transposition, RNA-mediated|double-strand break repair molecular_function Cul8-RING ubiquitin ligase complex|nucleus
YML017W PSP2 hom 0.00111201180156153 0.94865493896312 1199 Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing biological_process molecular_function cytoplasm
YOR357C SNX3 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.00111198572842173 0.948656141179114 1200 Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p protein localization|late endosome to Golgi transport phosphatidylinositol-3-phosphate binding cytosol|endosome
YJL121C RPE1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS 0.00111087560284131 0.948707328476203 1201 D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress pentose-phosphate shunt ribulose-phosphate 3-epimerase activity cytosol
YGL212W VAM7 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION 0.001109460574652 0.94882599478762 1202 Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle fusion SNAP receptor activity|phosphatidylinositol-3-phosphate binding SNARE complex|fungal-type vacuole membrane
YOR104W PIN2 hom 0.00110836349963926 0.948823160992831 1203 Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated biological_process molecular_function cellular_component
YNL225C CNM67 hom FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON 0.00110821114813715 0.948837805338156 1204 Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication microtubule nucleation|mitotic spindle organization structural constituent of cytoskeleton outer plaque of spindle pole body|spindle pole body
YFR013W IOC3 hom FT CHROMATIN ORGANIZATION|NUCLEUS 0.0011080824220078 0.948836121486826 1205 Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication chromatin remodeling nucleosome binding|ATPase activity|DNA binding ISW1 complex
YCR009C RVS161 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.00110733496809016 0.948885814639794 1206 Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress conjugation with cellular fusion|actin cytoskeleton reorganization|endocytosis|actin cortical patch localization|response to starvation|response to osmotic stress|lipid tube assembly|actin cytoskeleton organization cytoskeletal protein binding|lipid binding membrane raft|mating projection tip|mating projection|actin cortical patch
YDR326C YSP2 hom FT MITOCHONDRION 0.00110689810942478 0.94889073030718 1207 Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication apoptotic process molecular_function mitochondrion
YNL241C ZWF1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS 0.0011048871275087 0.948983457516683 1208 Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress NADPH regeneration|response to hydrogen peroxide|pentose-phosphate shunt, oxidative branch|carbon catabolite repression of transcription glucose-6-phosphate dehydrogenase activity cytoplasm
YDL223C HBT1 hom 0.00110469094184746 0.94906090256689 1209 Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis cell morphogenesis involved in conjugation with cellular fusion molecular_function plasma membrane|mating projection
YCR068W ATG15 hom FT LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.0011040825074179 0.949020559076019 1210 Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway membrane disassembly|autophagy|piecemeal microautophagy of nucleus|vacuolar protein processing|multivesicular body membrane disassembly lipase activity integral to membrane|vacuolar lumen
YCR025C_d YCR025C hom 0.00110380707004606 0.949033259699007 1211 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene Unknown Unknown Unknown
YNL097C PHO23 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.00110322542609515 0.949060079778637 1212 Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|chromatin modification|positive regulation of transcription from RNA polymerase II promoter methylated histone residue binding histone deacetylase complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YOR205C GEP3 hom FT MITOCHONDRION 0.00110249923313494 0.949101145518101 1213 Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1) maturation of SSU-rRNA molecular_function mitochondrion|mitochondrial inner membrane
YPR061C JID1 hom FT MITOCHONDRION 0.00110022309138518 0.949198520811323 1214 Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae biological_process molecular_function mitochondrion
YCR092C MSH3 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.00109997095666709 0.949210147096787 1215 Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability mismatch repair|mitotic recombination|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination DNA insertion or deletion binding|mismatched DNA binding|double-strand/single-strand DNA junction binding|loop DNA binding|Y-form DNA binding MutSbeta complex|nucleus|cytoplasm
YGL060W YBP2 hom FT CELL CYCLE|NUCLEUS|CHROMOSOME|KINETOCHORE 0.00109987695775735 0.949214481521113 1216 Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication G2/M transition of mitotic cell cycle molecular_function condensed nuclear chromosome kinetochore|centromere-specific nucleosome|cytoplasm
YPR059C_d YPR059C hom 0.0010961200875423 0.949425411818249 1217 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W Unknown Unknown Unknown
YKL181W PRS1 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 0.00109419937609637 0.949476285721946 1218 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YPL213W LEA1 hom FT RNA PROCESSING|NUCLEUS 0.00109330124302806 0.949517700863794 1219 Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein mRNA splicing, via spliceosome molecular_function U2 snRNP|U2-type prespliceosome|cytoplasm
YOR002W ALG6 hom FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00109267631270274 0.949546518030447 1220 Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation|aerobic respiration transferase activity, transferring hexosyl groups|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity integral to membrane|endoplasmic reticulum
YCR044C PER1 hom FF|FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00109234668256515 0.949576740849842 1221 Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 GPI anchor biosynthetic process|cellular manganese ion homeostasis molecular_function fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YJR033C RAV1 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM 0.00109071241943225 0.949637078698686 1222 Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate early endosome to late endosome transport|vacuolar acidification|regulation of protein complex assembly molecular_function RAVE complex|cytoplasm|extrinsic to membrane
YKL190W CNB1 hom FF|FT SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS 0.00109056717226527 0.949643776481831 1223 Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding calcineurin complex
YCR036W RBK1 hom FT CARBOHYDRATE METABOLISM|NUCLEUS 0.00109006078344291 0.949667127619267 1224 Putative ribokinase D-ribose metabolic process ribokinase activity|ATP binding nucleus|cytoplasm
YHR041C SRB2 hom FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|RNA POL II, HOLOENZYME 0.00108884840528213 0.949723034259944 1225 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding core mediator complex
YMR087W YMR087W hom FT RNA PROCESSING 0.00108882590166246 0.949724071976274 1226 Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain tRNA splicing, via endonucleolytic cleavage and ligation phosphatase activity cellular_component
YKL013C ARC19 het FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.00108563086705111 0.949871406453441 1227 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches mitochondrion inheritance|actin cortical patch assembly structural molecule activity Arp2/3 protein complex
YHR069C RRP4 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION|NUCLEUS 0.00108547919106549 0.949900795418774 1228 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2) nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|polyadenylation-dependent snoRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YOL072W THP1 hom FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.00108453675617743 0.949921860214353 1229 Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding mRNA export from nucleus|mRNA 3'-end processing|transcription-coupled nucleotide-excision repair|cellular bud site selection|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|transcription elongation from RNA polymerase II promoter double-stranded DNA binding|RNA binding nuclear envelope|nucleus|transcription export complex 2|nuclear pore
YGR271C-A EFG1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.00108440377105854 0.949927992695553 1230 Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus G1 phase of mitotic cell cycle|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus
YDR150W NUM1 hom FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|MITOCHONDRION|SITE OF POLARIZED GROWTH 0.00108362608692644 0.949963854912704 1231 Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex mitochondrion inheritance|nuclear migration along microtubule|mitochondrial fission|microtubule cytoskeleton organization tubulin binding cell cortex|mitochondrion|cellular bud tip
YML121W GTR1 hom FF|FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|GENE SILENCING|NUCLEUS 0.00108226888629938 0.950026441263998 1232 Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB phosphate ion transport|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|chromatin silencing at telomere GDP binding|GTP binding fungal-type vacuole membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YNL025C SSN8 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.00108215103230005 0.950031876032741 1233 Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter cyclin-dependent protein kinase regulator activity mediator complex
YOL023W IFM1 hom FT TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.00108044678054246 0.950110466872506 1234 Mitochondrial translation initiation factor 2 translational initiation|mitochondrial translational initiation|mitochondrial translation tRNA binding|GTPase activity|translation initiation factor activity mitochondrion
YCR043C_p YCR043C hom FT GOLGI APPARATUS|SITE OF POLARIZED GROWTH 0.00107953283070452 0.950152613477652 1235 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene biological_process molecular_function Golgi apparatus|mating projection tip
YLR087C CSF1 hom FF|FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.00107820822986588 0.950235942594013 1236 Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies fermentation molecular_function mitochondrion
YBR008C FLR1 hom FT PLASMA MEMBRANE 0.00107656350337232 0.950289544346453 1237 Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress drug transmembrane transport|transmembrane transport fluconazole transporter activity|drug transmembrane transporter activity integral to membrane|plasma membrane
YBR077C SLM4 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|SIGNALING 0.00107588730366825 0.950387349968724 1238 Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 signal transduction|microautophagy phosphatidylinositol-3,4-bisphosphate binding fungal-type vacuole membrane|EGO complex|late endosome membrane|cytoplasm
YLR303W MET17 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.00107025074598206 0.950580662744482 1239 Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis methionine metabolic process|cysteine biosynthetic process O-acetylhomoserine aminocarboxypropyltransferase activity|cysteine synthase activity plasma membrane|cytoplasm
YDL058W USO1 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|CYTOSKELETON 0.00106794002710886 0.950723954315726 1240 Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex Golgi vesicle docking|ER to Golgi vesicle-mediated transport|SNARE complex assembly molecular_function integral to membrane|ER to Golgi transport vesicle membrane|Golgi membrane
YMR070W MOT3 hom FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|NUCLEUS 0.00106665996741226 0.950746257622607 1241 Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion cellular hyperosmotic response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ergosterol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding nucleus
YJL080C SCP160 hom FT CELL CYCLE|SIGNALING|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.00106317796181978 0.95091414927288 1242 Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins meiotic telomere clustering|pheromone-dependent signal transduction involved in conjugation with cellular fusion|chromosome segregation|intracellular mRNA localization|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere G-protein alpha-subunit binding|RNA binding endoplasmic reticulum membrane|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YGL100W SEH1 hom FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE|NUCLEAR PORE 0.00106180552246734 0.950992040062867 1243 Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 nucleocytoplasmic transport structural constituent of nuclear pore fungal-type vacuole membrane|integral to membrane|nuclear pore|Seh1-associated complex|nuclear pore outer ring
YNL202W SPS19 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS 0.00106043039993302 0.951033549791492 1244 Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate fatty acid catabolic process|ascospore formation 2,4-dienoyl-CoA reductase (NADPH) activity peroxisomal matrix
YGR163W GTR2 hom FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION|NUCLEUS|CHROMOSOME 0.00105956243790886 0.951073578548555 1245 Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD microautophagy|positive regulation of transcription from RNA polymerase II promoter GTP binding nuclear chromatin|fungal-type vacuole membrane|integral to membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YLR453C RIF2 hom FT NUCLEUS|CHROMOSOME 0.00105745889853896 0.951177862107039 1246 Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation telomere capping|telomere maintenance via telomerase telomeric DNA binding nuclear telomere cap complex
YER097W_d YER097W hom 0.00105731227516743 0.951177352347126 1247 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR232W FUS2 hom FT SIGNALING|NUCLEUS|MITOCHONDRION|SITE OF POLARIZED GROWTH 0.00105719465824694 0.951182776668504 1248 Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating karyogamy involved in conjugation with cellular fusion|regulation of termination of mating projection growth|cytogamy molecular_function mitochondrion|nucleus|mating projection tip|cytoplasm
YOL115W PAP2 hom FT CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION|NUCLEUS 0.00105413478246939 0.951323894484593 1249 Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|base-excision repair|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U4 snRNA 3'-end processing|nuclear mRNA surveillance of mRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation|tRNA modification 5'-deoxyribose-5-phosphate lyase activity|polynucleotide adenylyltransferase activity nucleolus|nucleus|TRAMP complex
YPL084W BRO1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.00105398325673703 0.951330882710069 1250 Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes protein deubiquitination|vacuolar transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|response to nutrient|ubiquitin-dependent protein catabolic process ubiquitin-specific protease activity endosome|cytoplasm
YER120W SCS2 hom FT PROTEIN LOCALIZATION|LIPID METABOLISM|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH 0.00105126652799608 0.951456176340525 1251 Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication endoplasmic reticulum inheritance|regulation of intracellular lipid transport|negative regulation of transcription factor import into nucleus|phospholipid biosynthetic process|chromatin silencing at telomere phosphatidylinositol binding|FFAT motif binding nuclear membrane|integral to endoplasmic reticulum membrane|nuclear envelope|endoplasmic reticulum|cellular bud tip
YLR119W SRN2 hom FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT 0.00105058478698087 0.951487617947977 1252 Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole protein binding endosome|ESCRT I complex
YDR386W MUS81 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS 0.00104884929327751 0.951567658524545 1253 Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus crossover junction endodeoxyribonuclease activity|endonuclease activity Holliday junction resolvase complex|nucleus
YFR002W NIC96 het FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.00104740078263742 0.951634463881175 1254 Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) ribosomal large subunit export from nucleus|protein import into nucleus|nuclear pore organization structural constituent of nuclear pore integral to membrane|nuclear pore nuclear basket|nuclear pore linkers|nuclear pore
YDR289C RTT103 hom FT RNA PROCESSING|NUCLEUS|CHROMOSOME 0.00104672154434009 0.951665790490013 1255 Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition negative regulation of transposition, RNA-mediated|mRNA 3'-end processing RNA polymerase II core binding nuclear chromatin|site of double-strand break
YPR085C ASA1 het FT CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.00104618863474468 0.951690368441535 1256 Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 biological_process molecular_function ASTRA complex
YCR087W_d YCR087W hom 0.00104526163179844 0.951733122206873 1257 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene Unknown Unknown Unknown
YPR001W CIT3 hom FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.001044155173889 0.951784152692284 1258 Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate propionate catabolic process, 2-methylcitrate cycle|propionate metabolic process|tricarboxylic acid cycle 2-methylcitrate synthase activity|citrate (Si)-synthase activity mitochondrion
YPL227C ALG5 hom FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00104248200122647 0.951861320768609 1259 UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum protein N-linked glycosylation dolichyl-phosphate beta-glucosyltransferase activity endoplasmic reticulum membrane
YLR426W_p TDA5 hom FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.00104170003257317 0.951897385950043 1260 Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele response to drug molecular_function mitochondrion|integral to membrane
YPR027C_p YPR027C hom 0.00104144321983862 0.951909230433358 1261 Putative protein of unknown function biological_process molecular_function cellular_component
YMR073C IRC21 hom FF 0.00104077627259109 0.951997280942443 1262 Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study response to drug molecular_function cytoplasm
YMR166C_p YMR166C hom FT MITOCHONDRION 0.00103990781274866 0.952008657974726 1263 Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene transport transporter activity integral to membrane|mitochondrial inner membrane
YCR024C-A PMP1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.001038693080166 0.952036070538664 1264 Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication cation transport enzyme regulator activity plasma membrane|membrane
YCR106W RDS1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.00103846302015915 0.952046681267749 1265 Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide response to xenobiotic stimulus sequence-specific DNA binding|DNA binding nucleus
YOR115C TRS33 hom FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.00103789793767139 0.952072743796248 1266 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic ER to Golgi vesicle-mediated transport|protein complex assembly molecular_function trans-Golgi network|TRAPP complex|cis-Golgi network
YNL322C KRE1 hom FT CELL WALL ORG/BIOGENESIS|PLASMA MEMBRANE 0.00103725935627401 0.952102196276329 1267 Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor fungal-type cell wall organization structural constituent of cell wall fungal-type cell wall|integral to membrane
YER088C DOT6 hom FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING|NUCLEUS|CHROMOSOME 0.00103626896355696 0.952147875033158 1268 Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress chromatin silencing at rDNA|filamentous growth|regulation of transcription from RNA polymerase II promoter|unidimensional cell growth|chromatin silencing at telomere sequence-specific DNA binding Rpd3L-Expanded complex|nucleus|Rpd3L complex|cytoplasm
YKL073W LHS1 hom FT PROTEIN LOCALIZATION|NUCLEOTIDE METABOLISM|ENDOPLASMIC RETICULUM 0.00103528031909144 0.952193473314099 1269 Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway posttranslational protein targeting to membrane, translocation|response to unfolded protein unfolded protein binding|adenyl-nucleotide exchange factor activity|ATP binding endoplasmic reticulum lumen
YMR224C MRE11 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION 0.00103218761714264 0.95233611598823 1270 Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress DNA repair|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|base-excision repair|ascospore formation|meiotic DNA double-strand break processing|double-strand break repair via break-induced replication|regulation of transcription during meiosis 3'-5' exonuclease activity|protein complex scaffold|double-stranded telomeric DNA binding|adenylate kinase activity|telomeric DNA binding|single-stranded telomeric DNA binding|endodeoxyribonuclease activity|G-quadruplex DNA binding|endonuclease activity mitochondrion|nucleus|Mre11 complex
YPL135W ISU1 hom FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM|MITOCHONDRION 0.00103216443066472 0.952337185408793 1271 Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification ferrous iron binding mitochondrion|mitochondrial matrix
YCR079W PTC6 hom FT RESPONSE TO NUTRIENT LEVELS|MITOCHONDRION 0.00103195459953193 0.952346863369345 1272 Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase mitochondrion degradation|positive regulation of catalytic activity|macroautophagy|protein dephosphorylation protein serine/threonine phosphatase activity mitochondrion|mitochondrial matrix|mitochondrial intermembrane space
YDR226W ADK1 hom FT NUCLEOTIDE METABOLISM|MITOCHONDRION 0.00102962515986343 0.952454303689865 1273 Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress ADP biosynthetic process|DNA replication initiation|nucleotide metabolic process adenylate kinase activity mitochondrion|mitochondrial intermembrane space|cytoplasm
YBL072C RPS8A hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.00102766721197729 0.952544610430952 1274 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YJL036W SNX4 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT 0.00102742095444287 0.952555968649439 1275 Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p piecemeal microautophagy of nucleus|mitochondrion degradation|early endosome to Golgi transport|CVT pathway|protein targeting to vacuole phosphatidylinositol-3-phosphate binding cytosol|pre-autophagosomal structure|extrinsic to membrane|early endosome
YNL190W_p YNL190W hom 0.00102573497789741 0.952633731767218 1276 Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site cellular response to water deprivation molecular_function fungal-type cell wall
YLR422W_p YLR422W hom 0.00102386897570282 0.952719798821258 1277 Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein biological_process molecular_function cytoplasm
YHL004W MRP4 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0010237953118664 0.952723196486343 1278 Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome|tRNA binding mitochondrion|mitochondrial small ribosomal subunit
YIL004C BET1 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.00102375041861468 0.952725267139629 1279 Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|endoplasmic reticulum membrane|ER to Golgi transport vesicle
YOR322C LDB19 hom FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|GOLGI APPARATUS|PLASMA MEMBRANE 0.00102374882126041 0.952725340815894 1280 Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye ubiquitin-dependent endocytosis ubiquitin protein ligase binding cytosol|Golgi apparatus|plasma membrane|clathrin-coated vesicle|cytoplasm
YLR032W RAD5 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.00102361884288257 0.952731335931577 1281 DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress double-strand break repair|postreplication repair|protein polyubiquitination|free ubiquitin chain polymerization four-way junction helicase activity|four-way junction DNA binding|DNA-dependent ATPase activity|Y-form DNA binding nuclear chromatin
YML097C VPS9 hom FF|FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT 0.0010231821166558 0.952751479488066 1282 A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin vacuole inheritance|protein targeting to vacuole ubiquitin binding|guanyl-nucleotide exchange factor activity cytosol
YDR253C MET32 hom FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|NUCLEUS 0.00102293159230794 0.952784143525039 1283 Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication regulation of mitotic cell cycle|regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus|cytoplasm
YMR265C_p YMR265C hom 0.00102289702957811 0.952764628858106 1284 Putative protein of unknown function biological_process molecular_function cellular_component
YCL005W LDB16 hom FT MITOCHONDRION 0.00102286027130578 0.952766324299357 1285 Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria biological_process molecular_function mitochondrion|lipid particle
YPR042C PUF2 hom 0.00102035092003721 0.952903122079115 1286 Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay mRNA binding cytoplasm
YBR134W_d YBR134W hom 0.00101794948237759 0.952992831806432 1287 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR139C LOA1 hom FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM 0.00101679103870526 0.953060252284731 1288 Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA lipid particle organization|cellular triglyceride homeostasis|protein targeting to vacuole lysophosphatidic acid acyltransferase activity endoplasmic reticulum|lipid particle|cytoplasm
YNL175C NOP13 hom FT NUCLEUS 0.00101645501769199 0.953061763943127 1289 Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress biological_process RNA binding nucleolus|preribosome
YNL098C RAS2 hom FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS|PLASMA MEMBRANE 0.00101603506146899 0.953081134473922 1290 GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes pseudohyphal growth|ascospore formation|activation of adenylate cyclase activity|regulation of protein localization|replicative cell aging|positive regulation of transcription by galactose|Ras protein signal transduction GTP binding|GTPase activity plasma membrane
YML028W TSA1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|TRANSLATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS 0.00101516571653284 0.95312123320065 1291 Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress protein folding|cellular response to oxidative stress|replicative cell aging|DNA protection|DNA damage checkpoint|cell redox homeostasis|response to hydroperoxide unfolded protein binding|ribosome binding|peroxiredoxin activity|thioredoxin peroxidase activity cytosol|polysome|cytoplasm
YER039C-A_p YER039C-A hom 0.00101466761888429 0.953144208117899 1292 Putative protein of unknown function; YER039C-A is not an essential gene biological_process molecular_function integral to membrane
YCL051W LRE1 hom FT CELL WALL ORG/BIOGENESIS 0.00101455480588869 0.953149411659692 1293 Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway;
LRE1 has a paralog, HLR1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cellular_component
YDR310C SUM1 hom FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING|NUCLEUS 0.00101381033318687 0.953183750792727 1294 Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter during mitosis|DNA replication initiation|chromatin silencing at silent mating-type cassette DNA replication origin binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus
YBL062W_d YBL062W hom 0.0010127757326041 0.953231472346987 1295 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL180W TCO89 hom FT SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PLASMA MEMBRANE 0.00100820623127473 0.953442245258958 1296 Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin TOR signaling cascade|fungal-type cell wall organization|response to salt stress|regulation of cell growth|glycerol metabolic process molecular_function TORC1 complex|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|extrinsic to vacuolar membrane
YMR258C ROY1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|NUCLEUS 0.00100774546959646 0.953470429685006 1297 GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p endocytosis|protein targeting to vacuole|negative regulation of GTPase activity GTPase inhibitor activity nucleus|cytoplasm
YGL199C_d YGL199C hom 0.00100725385578469 0.95348617496071 1298 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W Unknown Unknown Unknown
YBR016W YBR016W hom FT PLASMA MEMBRANE 0.00100523670048683 0.953579219642785 1299 Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication biological_process molecular_function cellular bud membrane|plasma membrane|mating projection membrane
YFR019W FAB1 hom FT LIPID METABOLISM|MITOCHONDRION 0.00100436117991498 0.953647242682715 1300 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-phosphate 5-kinase activity|phosphatidylinositol-3-phosphate binding endosome membrane|mitochondrion|fungal-type vacuole membrane|PAS complex
YHL039W EFM1 hom 0.00100338966228769 0.953664417942149 1301 Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm peptidyl-lysine monomethylation protein-lysine N-methyltransferase activity cytoplasm
YNL316C PHA2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0010029102244837 0.953686533048081 1302 Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway L-phenylalanine biosynthetic process prephenate dehydratase activity cytoplasm
YBR140C IRA1 het FF|FT SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE 0.00100247377094463 0.953706665442795 1303 GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication negative regulation of cAMP biosynthetic process|negative regulation of Ras protein signal transduction|regulation of adenylate cyclase activity|positive regulation of Ras GTPase activity Ras GTPase activator activity mitochondrion|integral to membrane|membrane
YLR057W MNL2 hom FT PROTEOLYSIS|ENDOPLASMIC RETICULUM 0.000999714697720333 0.953833934542991 1304 Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene ER-associated protein catabolic process molecular_function endoplasmic reticulum
YLR313C SPH1 hom FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.000996394502334572 0.953987088355249 1305 Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p bipolar cellular bud site selection|pseudohyphal growth|invasive filamentous growth|mating projection assembly molecular_function incipient cellular bud site|cellular bud neck|cellular bud tip|mating projection
YGL172W NUP49 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.000996006235661778 0.954004998412588 1306 FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) poly(A)+ mRNA export from nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|tRNA export from nucleus nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|nuclear envelope|integral to membrane|nuclear pore
YKL058W TOA2 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.000995363535951707 0.954041491334377 1307 TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress transcription initiation from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly TBP-class protein binding|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|TBP-class protein binding RNA polymerase II transcription factor activity transcription factor TFIIA complex
YGR078C PAC10 hom FT PROTEIN COMPLEX ORG/BIOGENESIS 0.000995296689879754 0.954126804107289 1308 Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding tubulin complex assembly tubulin binding prefoldin complex|polysome|cytoplasm
YIL036W CST6 hom FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.000994521045944811 0.954073507810926 1309 Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication cellular response to carbon dioxide|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|DNA metabolic process sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YPL259C APM1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000993063698928941 0.954140733200237 1310 Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YOL081W IRA2 hom FT SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE 0.000992107543505604 0.954191663440843 1311 GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication negative regulation of cAMP biosynthetic process|negative regulation of Ras protein signal transduction|positive regulation of Ras GTPase activity|response to stress Ras GTPase activator activity mitochondrion|integral to membrane|cytoplasm
YIL157C COA1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000988772174186057 0.954338697155473 1312 Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly mitochondrial respiratory chain complex IV assembly molecular_function integral to mitochondrial membrane|mitochondrion|integral to mitochondrial inner membrane
YMR031W-A_d YMR031W-A hom 0.000987467925297568 0.954432832327401 1313 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C Unknown Unknown Unknown
YHR206W SKN7 hom FF|FT TRANSCRIPTION FROM RNA POL II|SIGNALING|RESPONSE TO OXIDATIVE STRESS|NUCLEUS 0.000987017778799718 0.954433205675081 1314 Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; SKN7 has a paralog, HMS2, that arose from the whole genome duplication response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|transcription, DNA-dependent|response to osmotic stress|regulation of cell size sequence-specific DNA binding|two-component response regulator activity|sequence-specific DNA binding transcription factor activity nucleus
YOR014W RTS1 hom FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CHROMOSOME SEGREGATION|NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON 0.000986918442684239 0.954430997267988 1315 B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A mitotic cell cycle spindle orientation checkpoint|cellular protein localization|meiotic sister chromatid cohesion, centromeric|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|spindle pole body|condensed nuclear chromosome, centromeric region|cellular bud neck|cytoplasm
YPL090C RPS6A hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.000985711398295505 0.954479889557575 1316 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YJL202C_d YJL202C het 0.000985374920995284 0.954495411211839 1317 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex Unknown Unknown Unknown
YHR195W NVJ1 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS 0.000985288231748126 0.954499410178374 1318 Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) microautophagy|cellular protein localization protein binding nuclear envelope
YHL044W_p YHL044W hom FT PLASMA MEMBRANE 0.00098472988974465 0.954525166468086 1319 Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern biological_process molecular_function plasma membrane
YIR009W MSL1 hom FT RNA PROCESSING|NUCLEUS 0.000984534183211186 0.954534194412279 1320 U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members mRNA splicing, via spliceosome U2 snRNA binding U2 snRNP|U2-type prespliceosome
YPR070W MED1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.000984528258304708 0.95453446772836 1321 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter molecular_function core mediator complex
YMR053C STB2 hom FT NUCLEUS|CHROMOSOME 0.000982787248449719 0.954635063960406 1322 Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p biological_process molecular_function Sin3-type complex
YPL062W_d YPL062W hom 0.000982247579438508 0.954666707348866 1323 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation Unknown Unknown Unknown
YCR099C_p YCR099C hom 0.000981296030268827 0.954683571282889 1324 Putative protein of unknown function biological_process molecular_function integral to membrane
YOR279C RFM1 hom FT GENE SILENCING|NUCLEUS 0.000981087538141015 0.954693189135682 1325 DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance chromatin silencing|chromatin silencing at silent mating-type cassette unfolded protein binding histone deacetylase complex|nucleus
YMR022W UBC7 hom FT CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000980733974885697 0.954709499211851 1326 Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly fungal-type cell wall organization|chromatin assembly or disassembly|ER-associated protein catabolic process ubiquitin-protein ligase activity endoplasmic reticulum membrane
YNL314W DAL82 hom FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.000978488194186042 0.954813098808584 1327 Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain allantoin catabolic process|nitrogen catabolite activation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YCR064C_d YCR064C hom FF 0.000977526127731391 0.954864203884121 1328 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 Unknown Unknown Unknown
YCR073W-A SOL2 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS 0.000977432264035031 0.954861809945165 1329 Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication tRNA export from nucleus molecular_function|6-phosphogluconolactonase activity cytosol|cytoplasm
YNR007C ATG3 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.000976674823111828 0.954896751572546 1330 E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly Atg8 ligase activity cytosol|cytoplasm
YMR253C_p YMR253C hom 0.000976591325835257 0.95490060340396 1331 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene biological_process molecular_function integral to membrane|cytoplasm
YGR233C PHO81 hom FT LIPID METABOLISM|NUCLEUS 0.000976327576437334 0.954912770492941 1332 Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress phosphate-containing compound metabolic process cyclin-dependent protein kinase inhibitor activity nucleus|cytoplasm
YKL032C IXR1 hom FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.000976002641763399 0.95494118821024 1333 Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b DNA repair|cellular response to hypoxia|negative regulation of transcription from RNA polymerase II promoter damaged DNA binding|sequence-specific DNA binding nuclear chromatin
YER184C_p YER184C hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.000975746469391111 0.954946289495076 1334 Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source biological_process sequence-specific DNA binding cellular_component
YJL092W SRS2 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.000975164556214433 0.954966422192916 1335 DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability DNA repair|double-strand break repair via nonhomologous end joining|DNA duplex unwinding DNA helicase activity nucleus
YDR276C PMP3 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.000974879944507523 0.955066805932188 1336 Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential regulation of membrane potential|cation transport molecular_function plasma membrane
YEL033W_p MTC7 hom 0.000972825695837552 0.955121180865413 1337 Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant biological_process molecular_function cellular_component
YPL173W MRPL40 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.000971502863627421 0.955135342368187 1338 Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YMR250W GAD1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS 0.000970711824231447 0.955171834640537 1339 Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress cellular response to oxidative stress|glutamate catabolic process calmodulin binding|glutamate decarboxylase activity cytoplasm
YCL061C MRC1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.000970209238226531 0.955195020014196 1340 S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres maintenance of DNA repeat elements|intra-S DNA damage checkpoint|DNA repair|DNA replication checkpoint|telomere maintenance|replication fork protection|DNA replication|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere molecular_function nuclear chromosome|replication fork protection complex|nucleus|nuclear replication fork
YBL008W-A_p YBL008W-A hom 0.000969729282119746 0.955257199513243 1341 Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YBR229C ROT2 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.000969076116653209 0.955247293489152 1342 Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations fungal-type cell wall biogenesis alpha-glucosidase activity glucosidase II complex|mitochondrion|endoplasmic reticulum|endoplasmic reticulum lumen
YGL190C CDC55 hom FT CELL CYCLE|SIGNALING|NUCLEUS|SITE OF POLARIZED GROWTH 0.000968592140791514 0.955269620454892 1343 Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion negative regulation of exit from mitosis|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|protein dephosphorylation protein phosphatase type 2A regulator activity nucleus|cellular bud neck|cytoplasm|cellular bud tip
YPR120C CLB5 hom FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS 0.000968405811826487 0.955278216265706 1344 B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase spindle assembly|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation|premeiotic DNA replication|positive regulation of DNA replication cyclin-dependent protein kinase regulator activity nucleus
YPR051W MAK3 hom FT NUCLEUS 0.000967918775854401 0.955300684450673 1345 Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatC complex
YNL257C SIP3 hom FT TRANSCRIPTION FROM RNA POL II 0.000967468584059344 0.955321452953371 1346 Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter transcription cofactor activity integral to membrane
YBR174C_d YBR174C hom 0.000967467178866106 0.955321517778589 1347 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective Unknown Unknown Unknown
YLR424W SPP382 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS|MITOCHONDRION 0.000966405392268633 0.955370500839163 1348 Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation spliceosomal complex disassembly|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step RNA binding|ATP-dependent RNA helicase activity mitochondrion|U2-type post-mRNA release spliceosomal complex|nucleus|spliceosomal complex|cytoplasm
YBR037C SCO1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION 0.00096525023699242 0.955423791438397 1349 Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication copper ion transport|response to redox state|protein complex assembly copper ion binding|thioredoxin peroxidase activity mitochondrion|mitochondrial inner membrane
YKL041W VPS24 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM 0.000964851783034096 0.955442173299283 1350 One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport molecular_function ESCRT III complex|cytoplasm
YBR074W_p YBR074W hom FT PROTEOLYSIS 0.000964818665625275 0.955450337943981 1351 Putative metalloprotease biological_process molecular_function cellular_component
YDR173C ARG82 hom FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.000963871355030279 0.955487403446896 1352 Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes protein stabilization|negative regulation of transcription from RNA polymerase II promoter|phosphatidylinositol phosphorylation|regulation of arginine metabolic process|inositol phosphate biosynthetic process|positive regulation of transcription from RNA polymerase II promoter inositol-1,4,5-trisphosphate 3-kinase activity|inositol-1,4,5-trisphosphate 6-kinase activity|phosphatidylinositol 3-kinase activity|protein binding, bridging|inositol tetrakisphosphate 6-kinase activity|inositol tetrakisphosphate 3-kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity nucleus
YOR068C VAM10 hom FT MEMBRANE ORGANIZATION 0.000963864835446294 0.955487704215759 1353 Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering vacuole fusion, non-autophagic molecular_function fungal-type vacuole membrane
YKL076C_d PSY1 hom 0.000963699406793403 0.955495335960642 1354 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C Unknown Unknown Unknown
YPL195W APL5 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000963169155003793 0.955519798173554 1355 Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function vesicle-mediated transport|Golgi to vacuole transport protein binding AP-3 adaptor complex
YOR327C SNC2 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000961519635268926 0.955595896068322 1356 Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion SNAP receptor activity SNARE complex|trans-Golgi network|endosome|transport vesicle membrane
YBR154C RPB5 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.00096082507214458 0.955694077809395 1357 RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YKR087C OMA1 hom FT PROTEOLYSIS|MITOCHONDRION 0.000960280993743863 0.955653039034972 1358 Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes misfolded or incompletely synthesized protein catabolic process metalloendopeptidase activity mitochondrion|mitochondrial inner membrane
YPR158W CUR1 hom FT NUCLEUS 0.000959816935587629 0.955674447757267 1359 Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication cellular response to stress|protein localization to nucleus chaperone binding nucleus
YGR243W FMP43 hom FT MITOCHONDRION 0.000959431659689357 0.955692221986363 1360 Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress mitochondrial pyruvate transport pyruvate transmembrane transporter activity mitochondrion|mitochondrial membrane
YIL075C RPN2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS 0.00095805086556598 0.955769105246856 1361 Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress proteasome assembly|ubiquitin-dependent protein catabolic process endopeptidase activity|protein binding, bridging proteasome regulatory particle, base subcomplex|nucleus|proteasome storage granule
YHR125W_d YHR125W hom 0.00095771240705767 0.95577153785754 1362 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR063C SPT4 hom FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.000953578762040756 0.955962240914905 1363 Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions 7-methylguanosine mRNA capping|chromosome segregation|chromatin organization|intracellular mRNA localization|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription, DNA-dependent|regulation of transcription-coupled nucleotide-excision repair|chromatin silencing|mRNA splicing, via spliceosome|Unknown core RNA polymerase I binding transcription factor activity|core RNA polymerase II binding transcription factor activity|rDNA binding DSIF complex|nuclear telomeric heterochromatin|rDNA heterochromatin|mating-type region heterochromatin|kinetochore
YLR020C YEH2 hom FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|PLASMA MEMBRANE 0.000952687667972765 0.956003351297796 1364 Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism cell wall mannoprotein biosynthetic process|sterol metabolic process sterol esterase activity integral to membrane|plasma membrane
YLR431C ATG23 hom FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.00095261175926122 0.956006853331002 1365 Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p protein localization to pre-autophagosomal structure|positive regulation of macroautophagy|CVT pathway molecular_function pre-autophagosomal structure|extrinsic to membrane
YBR056W-A_p YBR056W-A hom 0.000950266181981959 0.956115066487106 1366 Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B biological_process molecular_function cellular_component
YDR245W MNN10 hom FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.000950203187386109 0.956137585512346 1367 Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family N-glycan processing|cell wall mannoprotein biosynthetic process|substituted mannan metabolic process|barrier septum assembly alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YJL190C RPS22A hom FT TRANSLATION|RIBOSOME 0.000949421017922644 0.956154058310612 1368 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YPL094C SEC62 het FT PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000948685510376492 0.956187991192929 1369 Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation protein transporter activity integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YLR461W PAU4 hom 0.000947891717826225 0.95622461316211 1370 Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme biological_process molecular_function cellular_component
YPL102C_d YPL102C hom 0.000947610000138873 0.956237610353998 1371 Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4 Unknown Unknown Unknown
YOL126C MDH2 hom FT PROTEIN LOCALIZATION|KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|PEROXISOME ORGANIZATION 0.000946393797731622 0.956293720617444 1372 Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1 protein import into peroxisome matrix|gluconeogenesis|malate metabolic process L-malate dehydrogenase activity cytosol|cytoplasm
YOR210W RPB10 het FF|FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.000945236625371128 0.956347107693515 1373 RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase II, core complex
YNL136W EAF7 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.000944454927819657 0.956383172048552 1374 Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A DNA repair|histone acetylation|regulation of transcription from RNA polymerase II promoter molecular_function histone acetyltransferase complex|nucleus|NuA4 histone acetyltransferase complex
YPR032W SRO7 hom FT VESICLE-MEDIATED TRANSPORT|SIGNALING|PLASMA MEMBRANE 0.000943820321336727 0.95641245028382 1375 Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication establishment of cell polarity|exocytosis|Golgi to plasma membrane transport|small GTPase mediated signal transduction SNARE binding|Rab GTPase binding cytosol|plasma membrane
YGR227W DIE2 hom FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000940471907146761 0.95656693385459 1376 Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1 dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity integral to membrane|endoplasmic reticulum membrane
YCR049C_d YCR049C hom 0.000940322409011734 0.956573831189236 1377 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR170C APS1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000939296790420575 0.956621149824602 1378 Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YDR359C EAF1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.000938367173494104 0.956664039394034 1379 Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 DNA repair|cellular protein complex assembly|chromatin modification molecular_function histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YBL083C_d YBL083C hom 0.000938091523612266 0.956676757027314 1380 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3 Unknown Unknown Unknown
YDR232W HEM1 het FT COFACTOR METABOLISM|MITOCHONDRION 0.000938003826745522 0.956680803091911 1381 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p heme biosynthetic process 5-aminolevulinate synthase activity mitochondrion|mitochondrial matrix
YGL041C_d YGL041C hom 0.00093786192216623 0.956745452585006 1382 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YFL005W SEC4 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION|ENDOMEMBRANE SYSTEM|MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON 0.000937233266288571 0.956716354437204 1383 Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane bipolar cellular bud site selection|autophagy|exocytosis|Golgi to plasma membrane transport|small GTPase mediated signal transduction|ascospore-type prospore assembly|membrane addition at site of cytokinesis|vesicle fusion|cytokinesis GTP binding|GTPase activity mitochondrial outer membrane|vesicle|incipient cellular bud site|mitochondrion|transport vesicle|actin cap|plasma membrane
YER123W YCK3 hom FT VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION|ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE 0.000936943767211143 0.956761949049473 1384 Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway vesicle-mediated transport|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity fungal-type vacuole membrane|plasma membrane|nucleus|fungal-type vacuole
YCR061W_p YCR061W hom 0.000936850015902461 0.956734036491071 1385 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation regulation of cell size molecular_function integral to membrane|cytoplasm
YIL109C SEC24 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.000936400547652562 0.956767658512677 1386 Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p cargo loading into COPII-coated vesicle signal sequence binding COPII vesicle coat
YNL259C ATX1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS 0.000936242163225815 0.95678140653133 1387 Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake copper ion transport|cellular response to oxidative stress|cellular iron ion homeostasis copper chaperone activity cytosol
YBR187W_p GDT1 hom 0.000935599661636553 0.956823916194598 1388 Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis biological_process molecular_function integral to membrane|fungal-type vacuole
YNL005C MRP7 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.000935138810790847 0.95681942004277 1389 Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome|peptidyltransferase activity mitochondrion|mitochondrial large ribosomal subunit
YPR050C_d YPR050C hom 0.000934281636969284 0.956852534545095 1390 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W Unknown Unknown Unknown
YCL005W-A VMA9 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS 0.00093354301534251 0.956886612724849 1391 Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis cell wall mannoprotein biosynthetic process|vacuolar acidification|protein complex assembly|transmembrane transport ATPase activity, coupled to transmembrane movement of ions vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane
YNL121C TOM70 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000933473553459957 0.956889817528808 1392 Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication protein import into mitochondrial matrix|protein import into mitochondrial inner membrane mitochondrion targeting sequence binding|protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YOL002C IZH2 hom FT KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.000933293632139192 0.956898118668437 1393 Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc response to zinc ion|cellular zinc ion homeostasis|response to toxin|cellular lipid metabolic process protein binding|metal ion binding integral to membrane|plasma membrane|membrane
YKR014C YPT52 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.000933073587640537 0.956908271001928 1394 Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress endocytosis|protein targeting to vacuole GTPase activity late endosome
YCL016C DCC1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|CHROMOSOME 0.000932965565749912 0.956913254879405 1395 Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance maintenance of DNA trinucleotide repeats|response to DNA damage stimulus|mitotic sister chromatid cohesion molecular_function Ctf18 RFC-like complex
YDL151C_d BUD30 hom 0.000932955890121284 0.956965074684576 1396 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay Unknown Unknown Unknown
YOR194C TOA1 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.000932862344946151 0.956918017247532 1397 TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA transcription initiation from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly TBP-class protein binding|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly transcription factor TFIIA complex
YDR466W PKH3 hom FF|FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION 0.000932194901699048 0.956948811565729 1398 Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant MAPK cascade involved in cell wall biogenesis|protein phosphorylation protein kinase activity cellular_component
YPL096C-A ERI1 hom FT LIPID METABOLISM|SIGNALING|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000932187660534586 0.956968387659041 1399 Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein GPI anchor biosynthetic process|Ras protein signal transduction GTPase inhibitor activity glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane
YDL193W NUS1 het FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.000931713925486866 0.957028725435906 1400 Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY protein glycosylation prenyltransferase activity nuclear envelope|lipid particle|endoplasmic reticulum
YMR052C-A_d YMR052C-A hom 0.000931028499440691 0.957002626875628 1401 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR316W DIA1 hom 0.000930910250460628 0.957008082642044 1402 Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern pseudohyphal growth|invasive growth in response to glucose limitation molecular_function cytoplasm
YOL016C CMK2 hom FT SIGNALING|PROTEIN PHOSPHORYLATION 0.000930725817123892 0.957016592023514 1403 Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication signal transduction|protein phosphorylation protein kinase activity|calmodulin-dependent protein kinase activity cytoplasm
YOR097C_p YOR097C hom 0.000929150021111563 0.957095688470997 1404 Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene biological_process molecular_function cellular_component
YHR013C ARD1 hom FT CHROMATIN ORGANIZATION|RIBOSOME 0.000928780745212193 0.957106334008995 1405 Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress histone acetylation|N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity cytosolic ribosome|NatA complex
YMR268C PRP24 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS 0.000928749675252678 0.957107767523315 1406 Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling assembly of spliceosomal tri-snRNP|spliceosomal complex assembly U6 snRNA binding|snRNA binding U6 snRNP
YDR540C IRC4 hom FF|FT NUCLEUS 0.000927877643939997 0.95714800159991 1407 Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus mitotic recombination molecular_function nucleus|cytoplasm
YMR272C SCS7 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000927862309607554 0.957180635508291 1408 Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth inositolphosphoceramide metabolic process fatty acid alpha-hydroxylase activity integral to membrane|endoplasmic reticulum|membrane
YIL170W HXT12 hom 0.000927852102212482 0.957149180054446 1409 Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family hexose transport|biological_process hexose transmembrane transporter activity|molecular_function integral to membrane
YDR424C DYN2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON 0.000926696999313253 0.957202474756172 1410 Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex microtubule-based process|actin filament-based process|nuclear pore complex assembly molecular_function cytoplasmic dynein complex|cytoplasmic microtubule|peroxisome|nuclear pore
YKR055W RHO4 hom FT SIGNALING|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.00092622983015209 0.957224029289422 1411 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity positive regulation of formin-nucleated actin cable assembly|maintenance of cell polarity|regulation of formin-nucleated actin cable assembly GTPase activity incipient cellular bud site|plasma membrane|cellular bud neck
YNR006W VPS27 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT 0.000925631199409406 0.957302620542947 1412 Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole ubiquitin binding|phosphatidylinositol-3-phosphate binding endosome|ESCRT-0 complex
YLR455W YLR455W hom FT NUCLEUS 0.000924560207284176 0.957301063614323 1413 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YOR191W ULS1 hom FT CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION 0.000924385781615825 0.957309111420975 1414 Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress chromatin assembly or disassembly|mating type switching SUMO binding|DNA-dependent ATPase activity mitochondrion|nucleolus|nucleus
YPR018W RLF2 hom FT CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.000923334241348813 0.957357628413365 1415 Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription DNA replication-dependent nucleosome assembly histone binding chromosome, centromeric region|nucleus|CAF-1 complex
YLR460C_p YLR460C hom FT OXIDATION-REDUCTION PROCESS 0.000923304895588598 0.957358982398992 1416 Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine biological_process molecular_function cellular_component
YAL002W VPS8 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|GOLGI APPARATUS 0.000922630261068305 0.957409154717898 1417 Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole GTPase binding|protein anchor late endosome|membrane|CORVET complex
YMR315W YMR315W hom FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.000922610646580687 0.957391014427587 1418 Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress NADPH regeneration oxidoreductase activity nucleus|cytoplasm
YBR131W CCZ1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.000922139441852212 0.957412755431705 1419 Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway autophagy|autophagic vacuole fusion|vacuolar transport|vesicle docking|protein targeting to vacuole guanyl-nucleotide exchange factor activity Mon1-Ccz1 complex|membrane
YGR288W MAL13 hom FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|NUCLEUS 0.000921958836774041 0.957421088411972 1420 MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent sequence-specific DNA binding transcription factor activity nucleus
YKL057C NUP120 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.000921414369428785 0.957446209747278 1421 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160 double-strand break repair|protein export from nucleus|ribosomal large subunit export from nucleus|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore outer ring
YPL240C HSP82 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION 0.000919089601337025 0.957585098774225 1422 Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication proteasome assembly|positive regulation of telomere maintenance via telomerase|box C/D snoRNP assembly|response to stress|protein refolding|protein targeting to mitochondrion|response to osmotic stress|'de novo' protein folding unfolded protein binding|ATPase activity, coupled cytoplasm
YGL226W MTC3 hom FT MITOCHONDRION 0.000917684673068626 0.957618296413995 1423 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1 biological_process molecular_function mitochondrion
YMR209C_p YMR209C hom 0.000917507552595715 0.957626468729442 1424 Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity cellular_component
YMR134W ERG29 het FT LIPID METABOLISM|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.000916709641889083 0.957694828026842 1425 Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes cellular iron ion homeostasis|mitochondrion organization molecular_function nuclear envelope|endoplasmic reticulum|cytoplasm
YPL202C AFT2 hom FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|MITOCHONDRION 0.000916531810358134 0.957677795070194 1426 Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication cellular response to oxidative stress|cellular iron ion homeostasis|positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription mitochondrion|nucleus
YFR030W MET10 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.000916353273335323 0.9576797271325 1427 Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide sulfate assimilation sulfite reductase (NADPH) activity sulfite reductase complex (NADPH)
YNR058W BIO3 hom FT KETONE METABOLISM|COFACTOR METABOLISM 0.0009162658785659 0.957683759531672 1428 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis biotin biosynthetic process adenosylmethionine-8-amino-7-oxononanoate transaminase activity cytoplasm
YMR060C SAM37 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000916235624937375 0.957685155435906 1429 Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane|phospholipid transport molecular_function mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to membrane
YMR199W CLN1 hom FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS 0.000915703394341537 0.95771601256711 1430 G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) regulation of cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity nucleus|cytoplasm
YJL085W EXO70 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH 0.000914637444412912 0.957790368408317 1431 Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress Golgi to plasma membrane transport|exocytosis|exocyst localization|exocyst assembly|vesicle fusion|vesicle docking involved in exocytosis Rho GTPase binding|phosphatidylinositol-4,5-bisphosphate binding incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip|exocyst
YBR156C SLI15 hom FT CELL DIVISION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON 0.000914161977286214 0.957831175401797 1432 Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly chromosome segregation|protein phosphorylation|regulation of cytokinesis protein kinase activator activity spindle microtubule|spindle midzone|chromosome passenger complex|kinetochore microtubule
YLR192C HCR1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION 0.000912744380810029 0.957846242519274 1433 Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation initiation factor activity eukaryotic translation initiation factor 3 complex
YBR028C YPK3 hom FT PROTEIN PHOSPHORYLATION 0.000912677060063414 0.957868189141388 1434 An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner biological_process protein kinase activity cytoplasm
YIL105C SLM1 hom FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION|MITOCHONDRION|PLASMA MEMBRANE 0.000912189782744135 0.957871832004037 1435 Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol binding|sphingolipid binding eisosome|mitochondrion|membrane raft|plasma membrane|cytoplasm
YER139C RTR1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.000912023562144908 0.957892051892777 1436 CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication dephosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter CTD phosphatase activity nucleus|cytoplasm
YIL012W_d YIL012W hom 0.000911746366413343 0.957911112774959 1437 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR127W YPR127W hom FT OXIDATION-REDUCTION PROCESS|NUCLEUS 0.000911346214404605 0.957910754832363 1438 Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YOR076C SKI7 hom FT TRANSLATION|NUCLEOTIDE METABOLISM 0.000910167973340354 0.95796511986022 1439 Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay|nonfunctional rRNA decay protein binding, bridging Ski complex|cytoplasmic exosome (RNase complex)|cytoplasm
YEL036C ANP1 hom FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.000910111677932228 0.957967717382314 1440 Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol protein N-linked glycosylation alpha-1,6-mannosyltransferase activity|mannosyltransferase activity alpha-1,6-mannosyltransferase complex|Golgi cis cisterna
YIL027C EMC5 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000909936896164548 0.95798204237312 1441 Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YFR049W YMR31 hom FT TRANSLATION|MITOCHONDRION|RIBOSOME 0.000909411274718714 0.958000034670386 1442 Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 cytoplasmic translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YNL100W AIM37 hom FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000908695129554226 0.958033078378787 1443 Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YJL123C MTC1 hom FT GOLGI APPARATUS 0.00090810906562917 0.958060120052477 1444 Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 biological_process molecular_function COPI-coated vesicle|ribosome|Golgi apparatus|cytoplasm
YLR287C-A RPS30A hom FT TRANSLATION|RIBOSOME 0.000908092288615651 0.958060894164177 1445 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit|cytoplasmic stress granule
YPR038W_d IRC16 hom 0.000907385677751092 0.958093498080193 1446 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YNL071W LAT1 hom FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.000906989747245514 0.958111766843449 1447 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA acetyl-CoA biosynthetic process from pyruvate dihydrolipoyllysine-residue acetyltransferase activity mitochondrion|mitochondrial pyruvate dehydrogenase complex
YOR180C DCI1 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS 0.000906563091760695 0.958131453322973 1448 Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed fatty acid beta-oxidation dodecenoyl-CoA delta-isomerase activity peroxisomal matrix
YCR095C_p OCA4 hom 0.000904191911575816 0.958240863350767 1449 Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts biological_process molecular_function cytoplasm
YGL031C RPL24A hom FT TRANSLATION|RIBOSOME 0.000902643312612414 0.958312318596331 1450 Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YOR114W_p YOR114W hom 0.000902384805387562 0.958324246634636 1451 Putative protein of unknown function; null mutant is viable biological_process molecular_function cellular_component
YHR108W GGA2 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|GOLGI APPARATUS 0.000902255471422364 0.958330214364927 1452 Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to vacuole transport|Golgi to endosome transport ubiquitin binding|phosphatidylinositol-4-phosphate binding trans-Golgi network
YNL233W BNI4 hom FT PROTEIN LOCALIZATION|CELL DIVISION|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.000901678389228536 0.958356842130967 1453 Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p asymmetric protein localization|barrier septum assembly|chitin biosynthetic process protein binding incipient cellular bud site|cellular bud neck septin collar|cellular bud neck|septin ring
YNL199C GCR2 hom FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM|NUCLEUS 0.000900772490301571 0.958398642274853 1454 Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity nuclear envelope|nucleus
YNR060W FRE4 hom FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|PLASMA MEMBRANE 0.000900523737662643 0.95841631609188 1455 Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels siderophore transport ferric-chelate reductase activity integral to membrane|plasma membrane
YPR194C OPT2 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PLASMA MEMBRANE 0.000900412636121526 0.95842144180767 1456 Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles oligopeptide transport|vacuole fusion, non-autophagic oligopeptide transporter activity integral to membrane|integral to plasma membrane
YGR282C BGL2 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 0.000900330238926772 0.958419048755291 1457 Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance fungal-type cell wall organization 1,3-beta-glucanosyltransferase activity|glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall
YJR013W GPI14 het FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000899475067187275 0.958458508394147 1458 Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M fungal-type cell wall organization|GPI anchor biosynthetic process mannosyltransferase activity integral to membrane|endoplasmic reticulum membrane
YMR316C-A_p YMR316C-A hom 0.000899269999391167 0.958467970720529 1459 Protein of unknown function; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W biological_process molecular_function cellular_component
YHR152W SPO12 hom FT CELL CYCLE|NUCLEUS 0.000898399031576328 0.958508159356927 1460 Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis regulation of exit from mitosis|mitotic cell cycle|meiosis I molecular_function nucleolus|nucleus
YML128C MSC1 hom FT CELL CYCLE|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.000897676824182692 0.958541483894852 1461 Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated reciprocal meiotic recombination molecular_function mitochondrion|endoplasmic reticulum|plasma membrane
YDR479C PEX29 hom FT PEROXISOME ORGANIZATION 0.00089698632255142 0.958573345513703 1462 Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress peroxisome organization molecular_function integral to membrane|peroxisomal membrane
YNR056C BIO5 hom FT KETONE METABOLISM|COFACTOR METABOLISM|PLASMA MEMBRANE 0.000894948005912342 0.958673556910815 1463 Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis biotin biosynthetic process|vitamin transport transmembrane transporter activity integral to membrane|plasma membrane
YKL028W TFA1 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION|RNA POL II, HOLOENZYME 0.000894357230732437 0.9586946595489 1464 TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening transcriptional open complex formation at RNA polymerase II promoter|transcription from RNA polymerase II promoter single-stranded DNA binding|TFIIH-class transcription factor binding|RNA polymerase II core binding mitochondrion|transcription factor TFIIE complex
YKR074W AIM29 hom 0.00089413164454503 0.95873583775499 1465 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function cytoplasm
YBR068C BAP2 hom FT PLASMA MEMBRANE 0.000893983378797577 0.958711910255313 1466 High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication amino acid transport|transmembrane transport amino acid transmembrane transporter activity integral to membrane|plasma membrane
YMR152W YIM1 hom FT RESPONSE TO DNA DAMAGE|OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.000893589387085577 0.958730090295427 1467 Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress response to DNA damage stimulus molecular_function mitochondrion|lipid particle|cytoplasm
YDR049W VMS1 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.000890831111931378 0.958857366550105 1468 Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans ER-associated protein catabolic process|mitochondria-associated protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process molecular_function cytosol|mitochondrion|endoplasmic reticulum membrane|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytoplasm
YJR001W AVT1 hom FT VACUOLAR TRANSPORT 0.000890342203765288 0.958990334086706 1469 Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid transport|vacuolar transport transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YLR029C RPL15A het FT TRANSLATION|RIBOSOME 0.000889326181081127 0.958926809651762 1470 Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YBL011W SCT1 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000889186938881202 0.958933234820036 1471 Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed phospholipid biosynthetic process glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity integral to membrane|endoplasmic reticulum
YER114C BOI2 hom FT SIGNALING|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.000888103275471876 0.958983239290272 1472 Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction phospholipid binding site of polarized growth|cellular bud|cellular bud neck
YOL113W SKM1 hom FT CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS|PLASMA MEMBRANE 0.000888067749976918 0.958990988916509 1473 Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth negative regulation of gene expression|cytokinetic cell separation|protein phosphorylation|sterol import protein serine/threonine kinase activity|protein kinase activity plasma membrane|nucleus
YDR378C LSM6 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000887112802568512 0.959102249481896 1474 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasmic mRNA processing body
YBR255W MTC4 hom 0.000886647425149629 0.959050418174988 1475 Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1 biological_process molecular_function cytoplasm
YMR233W TRI1 hom FT NUCLEUS 0.000885792117976257 0.959089885679649 1476 Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication biological_process molecular_function nucleolus|nucleus|cytoplasm
YEL042W GDA1 hom FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000884308038851599 0.959158367629727 1477 Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate protein glycosylation guanosine-diphosphatase activity|uridine-diphosphatase activity Golgi apparatus
YNL204C SPS18 hom FT SIGNALING|NUCLEOTIDE METABOLISM 0.000882742603385031 0.959230604046374 1478 Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation sporulation resulting in formation of a cellular spore molecular_function cellular_component
YOR325W_d YOR325W hom 0.000882625586974499 0.959236003737015 1479 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1 Unknown Unknown Unknown
YDL117W CYK3 hom FT CELL CYCLE|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.000881946515614383 0.959267339338306 1480 SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants barrier septum assembly involved in cell cycle cytokinesis|cytokinesis molecular_function cellular bud neck contractile ring|cellular bud neck|cytoplasm
YMR159C ATG16 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.000881751243999911 0.959276350116441 1481 Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway protein binding, bridging|Atg8 ligase activity Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YPR092W_d YPR092W hom 0.000881111588929359 0.95933618901353 1482 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLL014W EMC6 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000881069019818508 0.959338151901762 1483 Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|integral to membrane|endoplasmic reticulum
YCR086W CSM1 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|KINETOCHORE 0.000880861006482258 0.959335615418224 1484 Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation meiotic chromosome segregation|rDNA condensation|protein localization to nucleolar rDNA repeats|homologous chromosome segregation molecular_function nuclear envelope|nucleolus|monopolin complex
YJL094C KHA1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION|GOLGI APPARATUS 0.000879512699708288 0.959422028183074 1485 Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies monovalent inorganic cation transport potassium:hydrogen antiporter activity mitochondrion|integral to membrane|Golgi apparatus
YDR353W TRR1 het FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS 0.000878414484832775 0.959430325149531 1486 Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication cellular response to oxidative stress|cell redox homeostasis ferrous iron binding|thioredoxin-disulfide reductase activity cytosol
YPR104C FHL1 het FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|NUCLEUS|CHROMOSOME 0.000877288429690744 0.959506438273229 1487 Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter RNA polymerase II transcription corepressor binding|RNA polymerase II transcription coactivator binding|sequence-specific DNA binding|DNA binding nuclear chromatin|nucleolus|nucleus|CURI complex
YNL226W_d YNL226W hom 0.000876502782478265 0.959518541497862 1488 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C Unknown Unknown Unknown
YLR428C_d YLR428C hom 0.000875728046223786 0.959554292185181 1489 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 Unknown Unknown Unknown
YAR015W ADE1 hom FT NUCLEOTIDE METABOLISM|NUCLEUS 0.000875534674998264 0.959569239761284 1490 N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process phosphoribosylaminoimidazolesuccinocarboxamide synthase activity nucleus|cytoplasm
YBR245C ISW1 hom FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.000875333014716932 0.95957252119157 1491 ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions termination of RNA polymerase I transcription|nucleosome positioning|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|regulation of transcriptional start site selection at RNA polymerase II promoter|heterochromatin maintenance involved in chromatin silencing|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter nucleosome binding|ATPase activity|rDNA binding|DNA binding ISW1 complex|nucleolar chromatin
YER098W UBP9 hom FT PROTEOLYSIS 0.000874854297947207 0.959594611941519 1492 Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication protein deubiquitination ubiquitin-specific protease activity cytoplasm
YPR077C_d YPR077C hom 0.000873661457336934 0.95964965661487 1493 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1 Unknown Unknown Unknown
YNL211C_p YNL211C hom FT MITOCHONDRION 0.000872717945730705 0.959693195919449 1494 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene biological_process molecular_function mitochondrion
YNR001C CIT1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.000872532864498147 0.95970173669564 1495 Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication glutamate biosynthetic process|tricarboxylic acid cycle|acetyl-CoA catabolic process|citrate metabolic process citrate (Si)-synthase activity mitochondrion
YGL047W ALG13 het FT LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.000872421849115102 0.959706859624301 1496 Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress dolichol-linked oligosaccharide biosynthetic process N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity cytosol|UDP-N-acetylglucosamine transferase complex|extrinsic to endoplasmic reticulum membrane|endoplasmic reticulum|nucleus|cytoplasm
YOR165W SEY1 hom FT MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000872406378222476 0.959707573546028 1497 Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3 cellular membrane organization|endoplasmic reticulum organization|endoplasmic reticulum membrane fusion|endoplasmic reticulum inheritance GTPase activity integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum|cytoplasm
YKR042W UTH1 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|GENE SILENCING|MITOCHONDRION 0.0008693561506819 0.959848330353919 1498 Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication mitochondrion degradation|fungal-type cell wall biogenesis|negative regulation of chromatin silencing involved in replicative cell aging molecular_function mitochondrial outer membrane|fungal-type cell wall
YKL025C PAN3 hom FT RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION 0.000869086726526975 0.959860763350192 1499 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes DNA repair|mRNA 3'-end processing|postreplication repair poly(A)-specific ribonuclease activity PAN complex|cytoplasm
YJR111C_p YJR111C hom FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.000868207571702197 0.95990133338351 1500 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria biological_process molecular_function mitochondrion
YLR051C FCF2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000867029237555275 0.959961675649599 1501 Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus|nucleus
YDL001W RMD1 hom FT CELL CYCLE 0.000866936018773972 0.959960011450931 1502 Cytoplasmic protein required for sporulation biological_process molecular_function cytoplasm
YOL052C-A DDR2 hom 0.000866789262317258 0.959966783802144 1503 Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication response to stress molecular_function fungal-type vacuole|cytoplasm
YPR052C NHP6A hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.000865776273761299 0.960013530132654 1504 High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress mismatch repair|DNA replication-independent nucleosome organization|RNA polymerase II transcriptional preinitiation complex assembly|RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling nucleosome binding|sequence-specific DNA binding|DNA binding, bending MutSalpha complex|nucleus
YPR089W_p YPR089W hom FT GOLGI APPARATUS 0.000865619362864091 0.960020771104009 1505 Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p biological_process molecular_function cellular_component
YCR031C RPS14A hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS|RIBOSOME 0.000865278914047308 0.960036481815966 1506 Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome|mRNA binding small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YML001W YPT7 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT|MITOCHONDRION 0.000865051940784869 0.96007672678162 1507 Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7 regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole inheritance|Golgi to vacuole transport|vesicle-mediated transport|endocytosis GTPase activity mitochondrial outer membrane|fungal-type vacuole
YBR277C_d YBR277C hom 0.000864878585491006 0.960054955821699 1508 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W Unknown Unknown Unknown
YHR151C MTC6 hom 0.000864825555548599 0.960057403001868 1509 Protein of unknown function; mtc6 is synthetically sick with cdc13-1 biological_process molecular_function cellular_component
YMR307W GAS1 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|GENE SILENCING|NUCLEUS|MITOCHONDRION|PLASMA MEMBRANE 0.00086450350821542 0.96007226457327 1510 Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery fungal-type cell wall organization|chromatin silencing|filamentous growth 1,3-beta-glucanosyltransferase activity mitochondrion|membrane raft|primary cell septum|nuclear periphery|integral to membrane|fungal-type cell wall|plasma membrane|cellular bud scar|ER to Golgi transport vesicle
YKL096W-A CWP2 hom FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS 0.000864380401361204 0.960077945609241 1511 Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored fungal-type cell wall organization|regulation of pH structural constituent of cell wall fungal-type cell wall
YDR348C PAL1 hom FT SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.000863697090600374 0.960109478520795 1512 Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cell cortex|cellular bud neck|mating projection tip
YBR024W SCO2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION 0.000863676201558876 0.960110442493569 1513 Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication copper ion transport thioredoxin peroxidase activity mitochondrial envelope|mitochondrion
YMR065W KAR5 hom FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.000863460707093801 0.960120386983764 1514 Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone karyogamy involved in conjugation with cellular fusion molecular_function mitochondrion|endoplasmic reticulum membrane
YDR451C YHP1 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS|CHROMOSOME 0.000862311350555784 0.960173426802611 1515 Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription nuclear chromatin|nucleus
YMR116C ASC1 hom FT SIGNALING|TRANSLATION|RIBOSOME 0.000861250223942944 0.960222395196027 1516 G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation negative regulation of translation|glucose mediated signaling pathway|G-protein coupled receptor signaling pathway|invasive growth in response to glucose limitation G-protein alpha-subunit binding|GDP-dissociation inhibitor activity|signal transducer activity cytosolic small ribosomal subunit|cytoplasm
YHR156C LIN1 hom FT NUCLEUS|CHROMOSOME 0.000859199133178699 0.960317048434662 1517 Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication biological_process protein binding chromatin|nucleus|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YPL207W TYW1 hom FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS|ENDOPLASMIC RETICULUM 0.000858413726721142 0.960353293329307 1518 Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron wybutosine biosynthetic process molecular_function endoplasmic reticulum
YER111C SWI4 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS|CHROMOSOME 0.000856067980923808 0.960461545166612 1519 DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription SBF transcription complex|nuclear chromatin
YGL143C MRF1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000855645184564377 0.96050461305145 1520 Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability translational termination|mitochondrial translational termination|mitochondrial translation translation release factor activity mitochondrion
YJL127C SPT10 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS 0.000855631918914942 0.960481668703543 1521 Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box DNA repair|negative regulation of transcription from RNA polymerase II promoter|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette histone acetyltransferase activity|sequence-specific DNA binding nucleus
YDR394W RPT3 het FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS 0.000855221832593509 0.960500593528637 1522 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process ATPase activity proteasome regulatory particle, base subcomplex
YOR177C MPC54 hom FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|NUCLEUS|CYTOSKELETON 0.000854715808207455 0.960523945771991 1523 Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate ascospore wall assembly|vesicle docking structural molecule activity spindle pole body
YIL136W OM45 hom FT MITOCHONDRION 0.000853602977683931 0.960575301299832 1524 Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YOR072W_d YOR072W hom FF 0.000853312599941428 0.960588701841847 1525 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Unknown Unknown Unknown
YMR320W_d YMR320W hom 0.000853311609682166 0.960588747540998 1526 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL315C ATP11 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000853302810308404 0.96058915362043 1527 Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase mitochondrion organization|mitochondrial proton-transporting ATP synthase complex assembly unfolded protein binding mitochondrion|mitochondrial matrix
YCR085W_d YCR085W hom 0.000853279288337982 0.960596110701038 1528 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR281W YOR1 hom FT NUCLEOTIDE METABOLISM|PLASMA MEMBRANE 0.000852396041879213 0.960630999835872 1529 Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR) transport|response to drug xenobiotic-transporting ATPase activity integral to membrane|plasma membrane
YHR073W OSH3 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOPLASMIC RETICULUM 0.000852084806539178 0.960645362977928 1530 Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability karyogamy involved in conjugation with cellular fusion|endocytosis|exocytosis|positive regulation of phosphatase activity|maintenance of cell polarity|pseudohyphal growth|sterol transport|invasive growth in response to glucose limitation lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity cortical endoplasmic reticulum|cytoplasm
YGR121W-A_p YGR121W-A hom 0.000851888197020504 0.960654436280767 1531 Putative protein of unknown function biological_process molecular_function cellular_component
YOR109W INP53 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|CYTOSKELETON 0.000851563209926037 0.960669434072037 1532 Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity membrane|actin cortical patch|cytoplasm
YCR050C_p YCR050C hom 0.000849568658211856 0.960767326810658 1533 Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein biological_process molecular_function cellular_component
YIR030C DCG1 hom 0.000848807523078917 0.960796606499453 1534 Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain nitrogen compound metabolic process molecular_function cellular_component
YPR041W TIF5 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.000848511960398026 0.960810246506095 1535 Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2 mature ribosome assembly|negative regulation of translational initiation|regulation of translational initiation translation initiation factor binding|GDP-dissociation inhibitor activity|GTPase activator activity|translation initiation factor activity cytosolic small ribosomal subunit|multi-eIF complex
YGR119C NUP57 het FT PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.000846163390018539 0.960936102546229 1536 FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) NLS-bearing substrate import into nucleus|protein import into nucleus|nuclear pore organization|protein targeting to nuclear inner membrane nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore
YPL158C AIM44 hom FT SITE OF POLARIZED GROWTH 0.000845332659335839 0.960968604617901 1537 Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular bud neck
YIR039C YPS6 hom FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS|PLASMA MEMBRANE 0.000845318002985834 0.960957646090276 1538 Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance fungal-type cell wall organization aspartic-type endopeptidase activity fungal-type cell wall
YOR386W PHR1 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION 0.000845193234338736 0.960963404129881 1539 DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p photoreactive repair mRNA binding|deoxyribodipyrimidine photo-lyase activity mitochondrion|nucleus
YHR158C KEL1 hom FT CELL CYCLE|MEMBRANE ORGANIZATION|SITE OF POLARIZED GROWTH 0.000844035367562889 0.961016839468135 1540 Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate negative regulation of exit from mitosis|regulation of cell shape|cell morphogenesis|cytogamy|plasma membrane fusion molecular_function mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YLR238W FAR10 hom FT CELL CYCLE|SIGNALING|ENDOPLASMIC RETICULUM 0.000843362831315295 0.961047876972361 1541 Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate re-entry into mitotic cell cycle after pheromone arrest molecular_function endoplasmic reticulum
YNL138W SRV2 hom FT SIGNALING|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.000843343890086762 0.961048751109684 1542 CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis cytoskeleton organization|Ras protein signal transduction cytoskeletal protein binding|adenylate cyclase binding mating projection tip|actin cortical patch
YIL029C_p YIL029C hom 0.000843338588309597 0.961048995786604 1543 Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W biological_process molecular_function integral to membrane
YGL238W CSE1 het FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|ENDOMEMBRANE SYSTEM|NUCLEUS 0.000841544115986033 0.961154980114604 1544 Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation protein export from nucleus importin-alpha export receptor activity nuclear envelope|integral to membrane
YJL165C HAL5 hom FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS 0.000841213869425025 0.961204978279906 1545 Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication cellular cation homeostasis|protein phosphorylation|cellular protein localization|protein dephosphorylation protein kinase activity cellular_component
YNL203C_d YNL203C hom 0.000840265522995115 0.961190818311483 1546 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR144W_p YMR144W hom FT NUCLEUS 0.000840242979508154 0.96119185870206 1547 Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene biological_process molecular_function nucleus
YNL068C FKH2 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0008400673123766 0.961199965809876 1548 Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|negative regulation of transcription involved in G1 phase of mitotic cell cycle|Unknown|chromatin remodeling|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity nucleus
YKR075C_p YKR075C hom FT NUCLEUS 0.00083905933619976 0.961246484387846 1549 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS biological_process molecular_function nucleus|cytoplasm
YDR524C-B_p YDR524C-B hom FT PLASMA MEMBRANE 0.000838755672540547 0.961260498635399 1550 Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication biological_process molecular_function cellular_component
YBL010C_p YBL010C hom FT NUCLEUS 0.00083848679473012 0.961272907506581 1551 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles biological_process molecular_function clathrin-coated vesicle
YKR035C_d OPI8 hom 0.000837933905917857 0.961327263455019 1552 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A Unknown Unknown Unknown
YDL130W-A STF1 hom FT NUCLEOTIDE METABOLISM|MITOCHONDRION 0.000837749884544948 0.96130691639883 1553 Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress negative regulation of ATPase activity molecular_function mitochondrion|mitochondrial proton-transporting ATP synthase complex
YIL130W ASG1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.000837741038658843 0.96130732464275 1554 Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance biological_process sequence-specific DNA binding nucleus
YGL124C MON1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT 0.000837572777036197 0.961315090037944 1555 Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate autophagy|vesicle docking|protein targeting to vacuole molecular_function cytosol|fungal-type vacuole membrane|Mon1-Ccz1 complex
YDL073W_p YDL073W hom 0.000837174641285196 0.961350749938715 1556 Putative protein of unknown function; YDL073W is not an essential gene biological_process molecular_function cellular_component
YPL272C_p YPL272C hom 0.000837098800101887 0.961365775530788 1557 Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene biological_process molecular_function cellular_component
YDR335W MSN5 hom FT PROTEIN LOCALIZATION|RNA LOCALIZATION|NUCLEUS 0.000837027750937727 0.961340243410511 1558 Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm tRNA re-export from nucleus|protein export from nucleus protein binding|importin-alpha export receptor activity integral to membrane|nucleus|cytoplasm
YBR296C-A_p YBR296C-A hom 0.000836967758154773 0.961343012125819 1559 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YGR090W UTP22 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000836891308732784 0.961363820126781 1560 Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing molecular_function small-subunit processome|nucleolus|nucleus|UTP-C complex|90S preribosome|CURI complex
YCL040W GLK1 hom FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.000836700816179742 0.961401417952433 1561 Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication glucose import|mannose metabolic process|glycolysis|glucose metabolic process glucokinase activity cytosol|plasma membrane
YJL139C YUR1 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000836608396813796 0.961359596951227 1562 Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication cell wall mannoprotein biosynthetic process|protein N-linked glycosylation mannosyltransferase activity Golgi apparatus
YPL177C CUP9 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.000836122007825731 0.961382044235042 1563 Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YGL127C SOH1 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|RNA POL II, HOLOENZYME 0.000836089070097377 0.961383564341568 1564 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits DNA repair|meiotic gene conversion|meiotic sister chromatid segregation|transcription from RNA polymerase II promoter molecular_function core mediator complex|nucleus
YDL116W NUP84 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.000835122475334543 0.96142817364334 1565 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107 double-strand break repair|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|maintenance of chromatin silencing at telomere|nuclear pore distribution|telomere tethering at nuclear periphery|response to DNA damage stimulus|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette structural constituent of nuclear pore integral to membrane|nuclear pore outer ring|nuclear pore
YKL078W DHR2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000833805883779604 0.961488935836462 1566 Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosome biogenesis RNA helicase activity nucleolus
YOR179C SYC1 hom FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS 0.000833565926626301 0.96150001015527 1567 Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication termination of RNA polymerase II transcription, exosome-dependent|termination of RNA polymerase II transcription, poly(A)-coupled RNA binding mRNA cleavage and polyadenylation specificity factor complex|nucleus
YBR286W APE3 hom FT PROTEOLYSIS 0.000833273184643198 0.96151352056918 1568 Vacuolar aminopeptidase Y, processed to mature form by Prb1p vacuolar protein catabolic process aminopeptidase activity fungal-type vacuole
YPL081W RPS9A hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS|RIBOSOME 0.000832942362808605 0.961528788429844 1569 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome|rRNA binding small-subunit processome|cytosolic small ribosomal subunit|90S preribosome|cytoplasm
YKL112W ABF1 het FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS 0.000832608187096166 0.961544211090676 1570 DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette DNA replication origin binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding, bending nucleotide-excision repair factor 4 complex|nucleus
YJR032W CPR7 hom 0.000832587389028996 0.961545170950065 1571 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity protein refolding|response to stress unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity cytosol
YGR270W YTA7 hom FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.000831855156024039 0.961578964545241 1572 Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter chromatin binding|histone binding extrinsic to endoplasmic reticulum membrane|nucleus
YLR430W SEN1 het FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000831529835845093 0.961593978556584 1573 Presumed helicase and subunit of the Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3' end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; has a separate role in coordinating DNA replication with transcription, by associating with moving replication forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, which is implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of ALS tRNA processing|mRNA 3'-end processing|termination of RNA polymerase II transcription|mRNA polyadenylation|snoRNA 3'-end processing|rRNA processing|snRNA processing ATP-dependent 5'-3' DNA helicase activity|DNA-dependent ATPase activity|RNA-dependent ATPase activity|ATP-dependent 5'-3' RNA helicase activity|protein domain specific binding Nrd1 complex|nucleus
YLR437C DIF1 hom FT NUCLEUS 0.000831180695736672 0.961610091908336 1574 Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein biological_process molecular_function cytoplasm
YGL175C SAE2 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS 0.000830995624781245 0.961647234749118 1575 Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents DNA double-strand break processing|DNA catabolic process, endonucleolytic|meiotic DNA double-strand break formation|meiotic DNA double-strand break processing|gene conversion at mating-type locus, DNA double-strand break processing double-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity nucleus|cytoplasm
YOR243C PUS7 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0008304458894301 0.961649719218367 1576 Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria snRNA pseudouridine synthesis|tRNA pseudouridine synthesis|enzyme-directed rRNA pseudouridine synthesis pseudouridine synthase activity nucleus
YGR166W TRS65 hom FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|GOLGI APPARATUS 0.000830074819397019 0.961661129901774 1577 Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response intra-Golgi vesicle-mediated transport|protein complex assembly Rab guanyl-nucleotide exchange factor activity TRAPP complex|trans-Golgi network
YPL134C ODC1 hom FT MITOCHONDRION 0.000828983886131696 0.961711478401881 1578 Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation mitochondrial transport dicarboxylic acid transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YMR083W ADH3 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.000828923282721494 0.961714275360949 1579 Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity mitochondrion|mitochondrial matrix
YKR084C HBS1 hom FT TRANSLATION|NUCLEOTIDE METABOLISM 0.000828822407804263 0.961718930925328 1580 GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nonfunctional rRNA decay ribosome binding|GTPase activity cytoplasm
YPL174C NIP100 hom FT CELL CYCLE|CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.000828313996728541 0.96177660894735 1581 Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) establishment of mitotic spindle orientation microtubule binding dynactin complex|cell cortex|spindle pole body|astral microtubule
YBR195C MSI1 hom FT CHROMATIN ORGANIZATION|NUCLEUS 0.000828289509357416 0.961743525197903 1582 Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase DNA replication-dependent nucleosome assembly histone binding nucleus|CAF-1 complex|cytoplasm
YOR262W GPN2 het FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION 0.000828179291089452 0.961748611984254 1583 Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion establishment of mitotic sister chromatid cohesion molecular_function cytoplasm
YER084W_p YER084W hom 0.000827622161400748 0.961780020054393 1584 Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YBR295W PCA1 hom FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|PLASMA MEMBRANE 0.000827331247984891 0.961810529717854 1585 Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function cadmium ion transport|cellular iron ion homeostasis|cellular metal ion homeostasis|transmembrane transport copper-transporting ATPase activity|cadmium-exporting ATPase activity|copper ion binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism integral to membrane|plasma membrane
YOL017W ESC8 hom FT GENE SILENCING|NUCLEUS 0.000826910701838056 0.961807159945057 1586 Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication chromatin silencing molecular_function nucleus
YML063W RPS1B hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.000826092369734328 0.961844927736705 1587 Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YOR184W SER1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.000825879620211832 0.961894548738446 1588 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress serine family amino acid biosynthetic process|L-serine biosynthetic process|purine nucleobase biosynthetic process O-phospho-L-serine:2-oxoglutarate aminotransferase activity cytoplasm
YKL145W RPT1 het FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS 0.000825530346936617 0.961870866350623 1589 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of protein catabolic process|proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process ATPase activity proteasome regulatory particle, base subcomplex
YMR179W SPT21 hom FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING|NUCLEUS 0.000825460965803923 0.961874068448463 1590 Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette molecular_function nucleus
YPR171W BSP1 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON 0.000825096174728132 0.961924985679337 1591 Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton actin cortical patch localization protein binding, bridging mating projection tip|membrane|cellular bud neck|actin cortical patch|cellular bud tip
YBR143C SUP45 het FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|CELL DIVISION 0.000824821057649416 0.961903601701239 1592 Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p translational termination|cytokinesis translation release factor activity, codon specific|translation release factor activity cytosol|translation release factor complex
YPL104W MSD1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000824546205755804 0.961916286772774 1593 Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene mitochondrial aspartyl-tRNA aminoacylation aspartate-tRNA ligase activity mitochondrion
YOR204W DED1 het FT TRANSLATION 0.000824332258749995 0.961926160944901 1594 ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility translational initiation RNA strand annealing activity|ATP-dependent RNA helicase activity cytoplasm
YBR099C_d YBR099C hom 0.000823765900126109 0.961952299794306 1595 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4 Unknown Unknown Unknown
YGR168C_p YGR168C hom 0.000823658334681164 0.961957264209898 1596 Putative protein of unknown function; YGR168C is not an essential gene biological_process molecular_function integral to membrane
YIL016W SNL1 hom FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.000822927110581824 0.961991012078688 1597 Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein protein folding|nuclear pore organization ribosome binding nuclear envelope|mitochondrion|cytosolic ribosome|endoplasmic reticulum membrane|membrane
YPL053C KTR6 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 0.000822502549534839 0.962010606691835 1598 Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication fungal-type cell wall organization|protein N-linked glycosylation mannosylphosphate transferase activity membrane
YOL124C TRM11 hom FT RNA PROCESSING 0.000822360525090351 0.962017161500009 1599 Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain tRNA methylation S-adenosylmethionine-dependent methyltransferase activity|RNA binding|tRNA (guanine-N2-)-methyltransferase activity cytoplasm|tRNA (m2G10) methyltransferase complex
YBL071C_d YBL071C hom 0.000821971458726758 0.962035117966981 1600 Dubious open reading frame, predicted protein contains a peroxisomal targeting signal Unknown Unknown Unknown
YOL050C_d YOL050C hom 0.000820782062376717 0.962090011950893 1601 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Unknown Unknown Unknown
YJR121W ATP2 hom FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION 0.000820771209056257 0.962090512862959 1602 Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|mitochondrial proton-transporting ATP synthase, catalytic core|integral to membrane
YDL203C ACK1 hom FT SIGNALING|CELL WALL ORG/BIOGENESIS|MITOCHONDRION 0.000820593421953332 0.962098718253048 1603 Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria fungal-type cell wall organization|positive regulation of signal transduction molecular_function mitochondrion
YKL186C MTR2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.000820458419381802 0.962104949015688 1604 mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA poly(A)+ mRNA export from nucleus|ribosomal large subunit export from nucleus protein binding integral to membrane|nuclear RNA export factor complex|nuclear pore
YBR252W DUT1 het FT NUCLEOTIDE METABOLISM|NUCLEUS 0.000819896872384166 0.962147795775402 1605 deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate pyrimidine deoxyribonucleoside triphosphate catabolic process|dUTP catabolic process|dITP catabolic process dITP diphosphatase activity|dUTP diphosphatase activity nucleus|cytoplasm
YFR032C_p RRT5 hom 0.00081923729311515 0.962161307661435 1606 Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation biological_process molecular_function cellular_component
YOR091W TMA46 hom FT TRANSLATION 0.000819078788349871 0.962168623146401 1607 Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p cytoplasmic translation molecular_function polysomal ribosome|ribosome|cytoplasm
YBR182C-A_p YBR182C-A hom 0.000818793226228644 0.962209985218657 1608 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YPR075C OPY2 hom FT CELL CYCLE|SIGNALING|PLASMA MEMBRANE 0.000817227747065701 0.962254054660029 1609 Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress cell cycle arrest in response to pheromone|osmosensory signaling pathway molecular_function integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YLR191W PEX13 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION 0.000816049987899074 0.962308412262251 1610 Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p protein import into peroxisome matrix, docking protein binding, bridging peroxisomal membrane
YIL044C AGE2 hom FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|GOLGI APPARATUS 0.00081587288069421 0.962322201138926 1611 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport ARF GTPase activator activity clathrin-coated vesicle
YJR097W JJJ3 hom FT NUCLEUS 0.000815602929220072 0.962329045590821 1612 Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 peptidyl-diphthamide biosynthetic process from peptidyl-histidine ferrous iron binding nucleus|cytoplasm
YGR156W PTI1 het FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS 0.00081326197908816 0.962437089074702 1613 Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 termination of RNA polymerase II transcription, exosome-dependent|mRNA cleavage|termination of RNA polymerase II transcription, poly(A)-coupled|mRNA polyadenylation|snoRNA 3'-end processing RNA binding mRNA cleavage and polyadenylation specificity factor complex|nucleus
YDR347W MRP1 hom FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.000812579784122326 0.962468575018684 1614 Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YIR027C DAL1 hom 0.000811983068493719 0.962496115807641 1615 Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression allantoin assimilation pathway allantoinase activity cellular_component
YCR051W_p YCR051W hom FT NUCLEUS 0.000810619195513494 0.962559064113835 1616 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YOL039W RPP2A hom FT TRANSLATION|RIBOSOME 0.000810477159538776 0.962571197376571 1617 Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm translational elongation|cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YMR153W NUP53 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.000809667561482296 0.962602986047718 1618 FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication positive regulation of transcription, DNA-dependent|NLS-bearing substrate import into nucleus|regulation of protein desumoylation|nuclear pore organization|protein import into nucleus|regulation of mitosis|mitotic cell cycle spindle assembly checkpoint nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YBR056W YBR056W hom FT CARBOHYDRATE METABOLISM 0.000809537229653239 0.962636866027307 1619 Putative glycoside hydrolase of the mitochondrial intermembrane space biological_process molecular_function cytoplasm
YOR121C_d YOR121C hom 0.000808881791693002 0.962667094825956 1620 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W Unknown Unknown Unknown
YLR412C-A_p YLR412C-A hom 0.00080861730984977 0.962651459732516 1621 Putative protein of unknown function biological_process molecular_function cellular_component
YNL140C_p YNL140C hom 0.000808573490988806 0.962653482166702 1622 Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C biological_process molecular_function cellular_component
YDR383C NKP1 hom FT CELL CYCLE|CELL DIVISION|NUCLEUS|CHROMOSOME|KINETOCHORE 0.000808524528664494 0.962655741994748 1623 Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4 biological_process molecular_function kinetochore
YOR185C GSP2 hom FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM|NUCLEUS 0.000807780192832702 0.96270677648716 1624 GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress nucleus organization GTPase activity integral to membrane|nucleus
YPL018W CTF19 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE 0.000807151483748962 0.962719114218759 1625 Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2 attachment of spindle microtubules to kinetochore|chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function COMA complex|condensed nuclear chromosome kinetochore|nucleus
YFR051C RET2 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000806819021374392 0.962734458894283 1626 Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER retrograde vesicle-mediated transport, Golgi to ER|Golgi inheritance|ER to Golgi vesicle-mediated transport|Golgi localization molecular_function COPI vesicle coat
YNL179C_d YNL179C hom 0.000806426919874552 0.962752556208873 1627 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YPR129W SCD6 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION 0.000805961945011869 0.962774016994199 1628 Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress stress granule assembly|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly mRNA binding|RNA binding|eukaryotic initiation factor 4G binding cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YLR451W LEU3 hom FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.000805787699144156 0.962787604777417 1629 Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YDR539W FDC1 hom FT KETONE METABOLISM|COFACTOR METABOLISM|PLASMA MEMBRANE 0.000804806534383232 0.962827344766757 1630 Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm cinnamic acid catabolic process molecular_function cytoplasm
YLR264C-A_p YLR264C-A hom 0.00080385631569008 0.962871202066514 1631 Putative protein of unknown function biological_process molecular_function cellular_component
YDL160C-A MHF2 hom FT RESPONSE TO DNA DAMAGE 0.000803549728462071 0.962885352609785 1632 Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2 response to DNA damage stimulus molecular_function cellular_component
YOR217W RFC1 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|NUCLEUS|CHROMOSOME 0.000802548481237273 0.962931565288698 1633 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon DNA repair|mismatch repair|mitotic cell cycle|leading strand elongation DNA clamp loader activity DNA replication factor C complex
YPL103C FMP30 hom FT LIPID METABOLISM|MITOCHONDRION 0.000802391729710052 0.962938800184441 1634 Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D N-acylphosphatidylethanolamine metabolic process|N-acylethanolamine metabolic process NAPE-specific phospholipase D activity mitochondrion|integral to mitochondrial inner membrane
YGL185C_p YGL185C hom FT OXIDATION-REDUCTION PROCESS 0.000801962031735663 0.962986237418495 1635 Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor cytoplasm
YOR336W KRE5 het FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOPLASMIC RETICULUM 0.00080158767610587 0.962975911475253 1636 Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects (1->6)-beta-D-glucan biosynthetic process UDP-glucose:glycoprotein glucosyltransferase activity endoplasmic reticulum
YBR257W POP4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000801144000531807 0.96299638946425 1637 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing ribonuclease MRP activity|ribonuclease P activity nucleolar ribonuclease P complex|ribonuclease MRP complex
YHR103W SBE22 hom FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS|GOLGI APPARATUS 0.000800690606069957 0.96301731605685 1638 Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth fungal-type cell wall organization molecular_function cytoplasm
YBR284W_p YBR284W hom FT NUCLEOTIDE METABOLISM 0.000799789284031092 0.963058916991529 1639 Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication biological_process AMP deaminase activity|molecular_function cellular_component
YOR225W_d YOR225W hom 0.000798702370688861 0.963109084112161 1640 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR048W RPS0B hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME 0.000798463530396879 0.963120107945015 1641 Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2 cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YIL097W FYV10 hom FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS 0.000798328714172501 0.963148312543829 1642 Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis ubiquitin-protein ligase activity nucleus|GID complex|cytoplasm
YKR079C TRZ1 het FT RNA PROCESSING|NUCLEUS|MITOCHONDRION 0.000797917045632334 0.96317279683376 1643 tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2 tRNA 3'-trailer cleavage, endonucleolytic 3'-tRNA processing endoribonuclease activity mitochondrion|nucleus|cytoplasm
YJR125C ENT3 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|CYTOSKELETON 0.000797051653063722 0.963185274228169 1644 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|actin filament organization|endocytosis|actin cortical patch assembly|Golgi to endosome transport protein binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding clathrin vesicle coat|actin cortical patch
YDR526C_d YDR526C het FF 0.000796343452523222 0.963234406267559 1645 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKR103W NFT1 hom FT NUCLEOTIDE METABOLISM 0.000795675903846228 0.963254249291932 1646 Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds. transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YDR194W-A_p YDR194W-A hom 0.000794492008824661 0.963330765049993 1647 Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YOL146W PSF3 het FT RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.000793786844887284 0.963335964898822 1648 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery double-strand break repair via break-induced replication|DNA-dependent DNA replication molecular_function replication fork protection complex|GINS complex|DNA replication preinitiation complex
YPL219W PCL8 hom FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS 0.000793432037021749 0.963352341509668 1649 Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation negative regulation of glycogen biosynthetic process cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YJL054W TIM54 het FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000793230542709765 0.963361641744236 1650 Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane protein import into mitochondrial inner membrane protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YFR035C_p YFR035C hom 0.000793024521616042 0.963371150923512 1651 Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein biological_process molecular_function cellular_component
YGR162W TIF4631 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION|RIBOSOME 0.000792914481436531 0.963376229977386 1652 Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication translational initiation|ribosomal large subunit biogenesis|stress granule assembly translation initiation factor activity mitochondrion|ribosome|eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YPR029C APL4 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000792291386484686 0.963404989798803 1653 Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YNL182C IPI3 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000792238501986051 0.963407430759202 1654 Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene ribosomal large subunit assembly|rRNA processing molecular_function nucleoplasm|nucleus
YDL204W RTN2 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000791924588118221 0.963421919914113 1655 Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network maintenance molecular_function endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YKL191W DPH2 hom 0.000791891395956973 0.963423451947696 1656 Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p peptidyl-diphthamide biosynthetic process from peptidyl-histidine molecular_function cytoplasm
YNL183C NPR1 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|GOLGI APPARATUS|PLASMA MEMBRANE 0.000791197937501331 0.963455459585251 1657 Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex regulation of transmembrane transporter activity|regulation of nitrogen utilization|protein phosphorylation|negative regulation of endocytosis protein serine/threonine kinase activity Golgi apparatus|plasma membrane|cytoplasm
YLR325C RPL38 hom FT TRANSLATION|RIBOSOME 0.000790925879916967 0.963468016835991 1658 Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR182W-A_p YDR182W-A hom 0.000790714921983518 0.963477753941348 1659 Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YBR111W-A SUS1 hom FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE|HISTONE ACETYLTRANSFERASE 0.000790383279453024 0.963525711951742 1660 Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP poly(A)+ mRNA export from nucleus|regulation of protein localization|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone deubiquitination|histone H3-K4 methylation|transcription elongation from RNA polymerase II promoter|histone H3-K79 methylation|positive regulation of transcription from RNA polymerase II promoter enzyme activator activity DUBm complex|nucleoplasm|transcription export complex 2|SAGA complex|nuclear pore
YDL150W RPC53 het FF|FT NUCLEUS 0.000790057867608788 0.963508081385903 1661 RNA polymerase III subunit C53 tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YNL308C KRI1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000790053221902733 0.963508295816431 1662 Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus
YHR087W RTC3 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000789834165922433 0.963523842668747 1663 Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress RNA metabolic process molecular_function nucleus|cytoplasm
YDR458C HEH2 hom FT ENDOMEMBRANE SYSTEM|NUCLEUS 0.000789808672515964 0.963546770394134 1664 Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle biological_process molecular_function nuclear envelope
YNR031C SSK2 hom FT SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH 0.000789640308439132 0.963527354555788 1665 MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress MAPK cascade involved in osmosensory signaling pathway|protein autophosphorylation|protein phosphorylation|response to osmotic stress|actin cytoskeleton organization|osmosensory signaling pathway via two-component system MAP kinase kinase kinase activity cytosol|cellular bud neck|cellular bud tip
YDR084C TVP23 hom FT VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000789399711548114 0.963538459733522 1666 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern vesicle-mediated transport molecular_function integral to membrane|integral to Golgi membrane|cytoplasm
YPL162C_p YPL162C hom 0.00078934556233089 0.963540959087996 1667 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YHR194W MDM31 hom FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|NUCLEUS|MITOCHONDRION 0.000789158272054133 0.963549603810203 1668 Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34 mitochondrion inheritance|cellular ion homeostasis|mitochondrion organization|Unknown molecular_function mitochondrial inner membrane|nucleus
YMR274C RCE1 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000789140587681242 0.963577584093514 1669 Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone CAAX-box protein processing|peptide pheromone maturation|protein processing metalloendopeptidase activity integral to endoplasmic reticulum membrane|integral to membrane
YBR027C_d YBR027C hom 0.000789133886171409 0.963550729385137 1670 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YML012W ERV25 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.000788658268833605 0.963572682386131 1671 Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport ER to Golgi vesicle-mediated transport molecular_function ER to Golgi transport vesicle
YPL265W DIP5 hom FT PLASMA MEMBRANE 0.000788282286099324 0.963590036586609 1672 Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress amino acid transport amino acid transmembrane transporter activity integral to membrane|plasma membrane
YLR253W_p YLR253W hom FT MITOCHONDRION 0.000788282158198002 0.963590042490141 1673 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene biological_process molecular_function mitochondrion
YMR086C-A_d YMR086C-A hom 0.000788045718308735 0.963600955833193 1674 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR073W RDH54 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS 0.000788043387889786 0.963601063398247 1675 DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p DNA geometric change|heteroduplex formation|meiotic sister chromatid segregation|reciprocal meiotic recombination|double-strand break repair via break-induced replication DNA-dependent ATPase activity|DNA translocase activity nucleus
YHL023C NPR3 hom FT CELL CYCLE|SIGNALING|RESPONSE TO NUTRIENT LEVELS 0.000787924685089404 0.963606542359523 1676 Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair meiosis|regulation of TOR signaling cascade|cellular response to amino acid starvation molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YHR160C PEX18 hom FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION 0.000787777156399433 0.963613351838836 1677 Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p protein import into peroxisome matrix protein binding cytosol|peroxisome
YNL101W AVT4 hom FT VACUOLAR TRANSPORT 0.000787386031392739 0.963631405002167 1678 Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid export from vacuole transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YKL110C KTI12 hom FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS 0.000786643430346446 0.963681925822331 1679 Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p regulation of transcription from RNA polymerase II promoter|cell growth|tRNA wobble uridine modification chromatin binding nucleus|cytoplasm
YIL013C PDR11 hom FT NUCLEOTIDE METABOLISM 0.000784801962567078 0.963777693369497 1680 ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth sterol transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YOR160W MTR10 het FT PROTEIN LOCALIZATION|RNA LOCALIZATION|NUCLEUS 0.000784602368596374 0.963759891109147 1681 Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress RNA localization|tRNA transport|RNA import into nucleus|protein import into nucleus|mRNA-binding (hnRNP) protein import into nucleus nuclear localization sequence binding integral to membrane|nucleus|cytoplasm
YDL040C NAT1 hom FT MITOCHONDRION|RIBOSOME 0.000783982935627492 0.963788482534554 1682 Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity mitochondrion|NatA complex|cytosolic ribosome
YIL066C RNR3 hom FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|MITOCHONDRION 0.000783865622394843 0.963793897415512 1683 Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits deoxyribonucleotide biosynthetic process ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor mitochondrion|ribonucleoside-diphosphate reductase complex|cytoplasm
YIL137C TMA108 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS 0.000783579813617253 0.963834062639383 1684 Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease ribosome biogenesis molecular_function ribosome|cytoplasm
YER106W MAM1 hom FT CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE 0.000782696083428895 0.963847880455919 1685 Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle meiotic chromosome segregation|meiotic sister chromatid cohesion involved in meiosis I molecular_function condensed nuclear chromosome kinetochore|monopolin complex
YPL203W TPK2 hom FT SIGNALING|PROTEIN PHOSPHORYLATION|NUCLEUS 0.000782176127921318 0.963871880375732 1686 cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase protein phosphorylation|Ras protein signal transduction|invasive growth in response to glucose limitation cAMP-dependent protein kinase activity|protein kinase activity nucleus|cAMP-dependent protein kinase complex
YIL030C SSM4 hom FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX 0.000782105182484044 0.963875155052315 1687 Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation ER-associated protein catabolic process ubiquitin-protein ligase activity nuclear envelope|integral to endoplasmic reticulum membrane|Doa10p ubiquitin ligase complex|integral to membrane|nuclear inner membrane
YHR104W GRE3 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS|NUCLEUS 0.000782020205828037 0.963879077378163 1688 Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress galactose catabolic process|cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process|response to stress D-xylose:NADP reductase activity|mRNA binding|glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity nucleus|cytoplasm
YOL041C NOP12 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000781621227302357 0.963913634338217 1689 Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA binding nucleolus|preribosome
YDL021W GPM2 hom FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.000781572546734055 0.963899740300705 1690 Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event biological_process phosphoglycerate mutase activity|molecular_function cytosol|cytoplasm
YBR182C SMP1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.000781255866443837 0.9639143575551 1691 Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress DNA binding, bending|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YNR005C_d YNR005C hom 0.000781191192213461 0.963917342774514 1692 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL258C THI21 hom 0.000781157645144595 0.963918891233206 1693 Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p thiamine biosynthetic process phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity cellular_component
YER169W RPH1 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS 0.000780990977391769 0.96392658425101 1694 JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|histone demethylation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific) nucleus
YMR062C ARG7 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|MITOCHONDRION 0.000780990263978168 0.963931992383628 1695 Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine fungal-type cell wall organization|ornithine biosynthetic process|arginine biosynthetic process acetyl-CoA:L-glutamate N-acetyltransferase activity|glutamate N-acetyltransferase activity mitochondrion|mitochondrial matrix
YDR058C TGL2 hom FT PROTEIN LOCALIZATION|LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.00078092737422056 0.963929520034734 1696 Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli triglyceride catabolic process triglyceride lipase activity mitochondrion
YLL002W RTT109 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS 0.000780189690788735 0.963990426479837 1697 Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p negative regulation of transposition, RNA-mediated|histone acetylation|double-strand break repair via nonhomologous end joining|response to DNA damage stimulus|regulation of transcription from RNA polymerase II promoter in response to stress H3 histone acetyltransferase activity nucleus
YCR075W-A_p YCR075W-A hom 0.000779438218744776 0.963998256344646 1698 Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication biological_process molecular_function cellular_component
YDR185C UPS3 hom FT MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000779028641159232 0.964017161638401 1699 Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations mitochondrion morphogenesis molecular_function extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YGR052W_p FMP48 hom FT PROTEIN PHOSPHORYLATION|MITOCHONDRION 0.000778010715063125 0.964064147187426 1700 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation protein phosphorylation protein kinase activity mitochondrion
YMR187C_p YMR187C hom 0.000777966320472754 0.96406619636084 1701 Putative protein of unknown function; YMR187C is not an essential gene biological_process molecular_function integral to membrane
YER188W_d YER188W hom 0.000777222090972966 0.964100548674025 1702 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p Unknown Unknown Unknown
YPR095C SYT1 hom FT VESICLE-MEDIATED TRANSPORT|SIGNALING|MITOCHONDRION|GOLGI APPARATUS 0.000776143244162267 0.964150346446795 1703 Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain vesicle-mediated transport|exocytosis|positive regulation of ARF protein signal transduction ARF guanyl-nucleotide exchange factor activity mitochondrion|Golgi apparatus part
YPR128C ANT1 hom FT KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|PEROXISOME ORGANIZATION 0.000775823845865133 0.964165089367296 1704 Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation ATP transport|fatty acid beta-oxidation|peroxisome organization adenine nucleotide transmembrane transporter activity integral to membrane|cytoplasm|integral to peroxisomal membrane
YNL010W_p YNL010W hom FT NUCLEUS 0.000775545679741154 0.964177929085839 1705 Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation biological_process molecular_function nucleus|cytoplasm
YER137C_p YER137C hom 0.000775379190659872 0.964185613969063 1706 Putative protein of unknown function biological_process molecular_function cellular_component
YPR012W_d YPR012W hom 0.000774922601673264 0.964217357290517 1707 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene Unknown Unknown Unknown
YPL226W NEW1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|NUCLEUS|MITOCHONDRION 0.000774654153324673 0.964219080630451 1708 ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction ribosomal small subunit biogenesis|poly(A)+ mRNA export from nucleus ATPase activity|ATP binding mitochondrion|polysome|cytoplasm
YOR011W AUS1 hom FT NUCLEOTIDE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE 0.000773057392131478 0.964303427234713 1709 Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen sterol import sterol-transporting ATPase activity mitochondrion|integral to membrane|plasma membrane
YJR075W HOC1 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|GOLGI APPARATUS 0.00077299095744532 0.964295851554009 1710 Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele cell wall mannoprotein biosynthetic process|substituted mannan metabolic process alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups alpha-1,6-mannosyltransferase complex
YGL087C MMS2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|NUCLEUS 0.000772809069750046 0.964304247269705 1711 Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress postreplication repair|response to DNA damage stimulus|protein polyubiquitination|free ubiquitin chain polymerization ubiquitin-protein ligase activity ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YIL072W HOP1 hom FT CELL CYCLE|NUCLEUS|CHROMOSOME 0.000772714941024117 0.96430859213923 1712 Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments synaptonemal complex assembly|meiotic recombination checkpoint|synapsis four-way junction DNA binding condensed nuclear chromosome|lateral element
YBR085C-A YBR085C-A hom FT NUCLEUS 0.000772543257109313 0.964316516866341 1713 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YDR536W STL1 hom FT PLASMA MEMBRANE 0.000772460921114706 0.964320317400036 1714 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock transport|glycerol transport|transmembrane transport solute:hydrogen symporter activity|transporter activity integral to membrane|plasma membrane|membrane
YPL048W CAM1 hom FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS 0.000772291397643165 0.964328142408758 1715 Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma ribosome biogenesis|positive regulation of transcription from RNA polymerase II promoter phospholipid binding|transcription coactivator activity|calcium ion binding nucleus
YMR056C AAC1 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.000772048694692543 0.964344659090066 1716 Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress heme biosynthetic process|mitochondrial transport|heme transport|aerobic respiration ATP:ADP antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YOL155C HPF1 hom FT CELL WALL ORG/BIOGENESIS 0.000770802285596594 0.964396878257826 1717 Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines fungal-type cell wall organization glucosidase activity fungal-type cell wall|extracellular region
YOR228C YOR228C hom FT MITOCHONDRION 0.00077076535030612 0.964398583155429 1718 Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion|integral to membrane
YLR037C PAU23 hom FT CELL WALL ORG/BIOGENESIS 0.000770362693269375 0.964443688380384 1719 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth biological_process molecular_function fungal-type cell wall
YNL032W SIW14 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION 0.000770097445558398 0.964429413026419 1720 Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm actin filament organization|endocytosis|protein dephosphorylation|response to stress protein tyrosine phosphatase activity cytoplasm
YGR210C_p YGR210C hom 0.000769142391749034 0.964473497527242 1721 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YLR449W FPR4 hom FT CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.000768288544146393 0.964518198481679 1722 Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones histone peptidyl-prolyl isomerization|negative regulation of histone H3-K36 methylation|regulation of transcription by chromatin organization|chromatin silencing at rDNA|nucleosome assembly peptidyl-prolyl cis-trans isomerase activity|macrolide binding chromatin|nucleus
YMR302C YME2 hom FT RNA PROCESSING|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000768007792473982 0.96455230788757 1723 Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases mitochondrial genome maintenance molecular_function mitochondrion|integral to mitochondrial inner membrane
YER091C-A_d YER091C-A hom 0.000767904113608472 0.964530655592575 1724 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR169W_d YLR169W hom 0.000767407847562424 0.964553562942302 1725 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBL090W MRP21 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.000767192049469537 0.964563524064872 1726 Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences mitochondrial translational initiation|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YDR261C EXG2 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PLASMA MEMBRANE 0.000765399773023271 0.964651522897667 1727 Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization glucan exo-1,3-beta-glucosidase activity fungal-type cell wall
YPL110C GDE1 hom FT LIPID METABOLISM|SIGNALING|CARBOHYDRATE METABOLISM 0.000765257151009889 0.96465283817196 1728 Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes glycerophospholipid catabolic process glycerophosphocholine phosphodiesterase activity ribosome|cytoplasm
YHR177W_p YHR177W hom 0.00076510478719396 0.964659871241092 1729 Putative protein of unknown function; overexpression causes a cell cycle delay or arrest biological_process molecular_function cellular_component
YNL075W IMP4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000765053340222179 0.964662246018867 1730 Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs rRNA processing snoRNA binding|single-stranded telomeric DNA binding|rRNA primary transcript binding small-subunit processome|Mpp10 complex|90S preribosome
YMR172C-A_d YMR172C-A hom 0.00076422601248538 0.96472674339557 1731 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YFL053W DAK2 hom FT CARBOHYDRATE METABOLISM 0.000763477824220081 0.964734971546847 1732 Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation response to stress|glycerol catabolic process glycerone kinase activity cellular_component
YPL184C MRN1 hom FT TRANSLATION 0.000763402839394331 0.964738432839884 1733 RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation biological_process molecular_function cytoplasm
YPL253C VIK1 hom FT CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS|CYTOSKELETON 0.000762667489533421 0.964772376560711 1734 Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p microtubule-based process|mitotic sister chromatid cohesion microtubule motor activity kinesin complex|spindle pole body
YMR262W_p YMR262W hom 0.000762627333654352 0.964774230156356 1735 Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene biological_process molecular_function cellular_component
YPR122W AXL1 hom FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|SITE OF POLARIZED GROWTH 0.000762036989622653 0.964801480462753 1736 Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells peptide pheromone maturation|axial cellular bud site selection metalloendopeptidase activity mating projection tip|cellular bud neck
YGL080W FMP37 hom FT MITOCHONDRION 0.000761969525961971 0.964804594590906 1737 Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia mitochondrial pyruvate transport pyruvate transmembrane transporter activity mitochondrion|integral to mitochondrial inner membrane
YAR047C_d YAR047C hom 0.000761788263590533 0.964812961679611 1738 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL141C FRK1 hom FT PROTEIN PHOSPHORYLATION 0.00076065664621384 0.964880906275953 1739 Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication protein phosphorylation protein kinase activity cytoplasm
YNL287W SEC21 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000760460845417285 0.96487423554963 1740 Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport molecular_function endosome|COPI vesicle coat
YNL095C_p YNL095C hom 0.000760233207706794 0.964884743369565 1741 Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YAR042W SWH1 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.00075969876668588 0.964909413339464 1742 Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction endocytosis|maintenance of cell polarity|exocytosis|sterol transport lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity nuclear envelope|endoplasmic reticulum|Golgi trans cisterna|early endosome
YKL039W PTM1 hom FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000759563812676634 0.964915642865368 1743 Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YPL201C YIG1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS 0.000759360204729867 0.964925041485923 1744 Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol glycerol biosynthetic process molecular_function cytosol|nucleus
YFL011W HXT10 hom FT MITOCHONDRION|PLASMA MEMBRANE 0.000759336358366185 0.964926142243493 1745 Putative hexose transporter, expressed at low levels and expression is repressed by glucose hexose transport|transmembrane transport galactose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YHR137W ARO9 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.000759221309236958 0.964936678628513 1746 Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism aromatic amino acid family metabolic process aromatic-amino-acid:2-oxoglutarate aminotransferase activity nucleus|cytoplasm
YGR265W_d YGR265W het 0.000759171029661757 0.964933773883655 1747 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase Unknown Unknown Unknown
YOL058W ARG1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.000759065298822537 0.96493865446383 1748 Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate argininosuccinate metabolic process|arginine biosynthetic process|citrulline metabolic process argininosuccinate synthase activity cytosol
YIL067C_p YIL067C hom 0.000759060804082681 0.964938861942948 1749 Uncharacterized protein of unknown function biological_process molecular_function integral to membrane|fungal-type vacuole
YOR220W RCN2 hom 0.000759046464324863 0.964944748342025 1750 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress biological_process molecular_function cytoplasm
YOR385W_p YOR385W hom 0.000758808462882176 0.964950510124734 1751 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene biological_process molecular_function cytoplasm
YMR011W HXT2 hom FT PLASMA MEMBRANE 0.000758362063117643 0.964971116154254 1752 High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose glucose transport pentose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YNL326C PFA3 hom FT MEMBRANE ORGANIZATION 0.000758171039170665 0.964979933919388 1753 Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions vacuole fusion, non-autophagic|protein palmitoylation palmitoyltransferase activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YNL081C SWS2 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.000757261055639607 0.965021939293073 1754 Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency regulation of sporulation resulting in formation of a cellular spore|mitochondrial translation structural constituent of ribosome mitochondrial small ribosomal subunit|cytoplasm
YOL114C_p YOL114C hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION 0.000757035701221189 0.965032341800238 1755 Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene biological_process molecular_function cellular_component
YER092W IES5 hom FT NUCLEUS 0.000756919996468785 0.965037682809503 1756 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions biological_process molecular_function nucleus
YPR170C_d YPR170C hom 0.000756863284532367 0.96504030067124 1757 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B Unknown Unknown Unknown
YLR432W IMD3 hom FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM 0.00075674578791281 0.965045724396685 1758 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed GTP biosynthetic process IMP dehydrogenase activity plasma membrane|cytoplasm
YNR032C-A HUB1 hom FT RNA PROCESSING 0.000756685524832286 0.965048506182902 1759 Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear cellular protein modification process|cell morphogenesis involved in conjugation with cellular fusion|mRNA splicing, via spliceosome protein tag mating projection
YIL124W AYR1 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.000756645333647923 0.965055569411132 1760 NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones phosphatidic acid biosynthetic process acylglycerone-phosphate reductase activity mitochondrial outer membrane|mitochondrion|integral to membrane|endoplasmic reticulum|lipid particle|cytoplasm
YPL183C RTT10 hom FT VESICLE-MEDIATED TRANSPORT 0.000756536421628855 0.965071012907697 1761 WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6 endocytic recycling molecular_function endosome|cytoplasm
YKR056W TRM2 hom FT RNA PROCESSING|RESPONSE TO DNA DAMAGE 0.000756302824447293 0.965071377533656 1762 tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair double-strand break repair|DNA repair|tRNA modification tRNA (m5U54) methyltransferase activity|double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity cellular_component
YHL026C_p YHL026C hom 0.000756158589106626 0.965078034555832 1763 Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) biological_process molecular_function cellular_component
YGR224W AZR1 hom FT PLASMA MEMBRANE 0.000756105141031398 0.965075297129457 1764 Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole azole transport azole transporter activity integral to membrane|plasma membrane
YML019W OST6 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000756029912819636 0.965078769722373 1765 Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p protein N-linked glycosylation via asparagine|protein complex assembly dolichyl-diphosphooligosaccharide-protein glycotransferase activity oligosaccharyltransferase complex|integral to membrane
YNL284C MRPL10 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.000755913776798142 0.965094537328492 1766 Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YDR246W-A_p YDR246W-A hom 0.000755840579821779 0.965087509484121 1767 Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YPL236C ENV7 hom FT PROTEIN PHOSPHORYLATION|VACUOLAR PROTEIN PROCESSING 0.000755803154915451 0.965094439237095 1768 Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16) vacuolar protein processing protein serine/threonine kinase activity fungal-type vacuole membrane
YCL028W RNQ1 hom FT NUCLEUS 0.000755732661494333 0.965092491081814 1769 [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate biological_process molecular_function cytosol
YJL197W UBP12 hom FT PROTEOLYSIS|NUCLEUS 0.000754563618490904 0.965146455144095 1770 Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm biological_process ubiquitin-specific protease activity nucleus|cytoplasm
YKR005C_p YKR005C hom 0.0007542728473255 0.965159877423868 1771 Putative protein of unknown function biological_process molecular_function cellular_component
YPL097W MSY1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000753727559394832 0.965185048471647 1772 Mitochondrial tyrosyl-tRNA synthetase mitochondrial tyrosyl-tRNA aminoacylation tyrosine-tRNA ligase activity mitochondrion
YPR091C NVJ2 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00075363933752257 0.965189120886631 1773 Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments biological_process lipid binding ribosome|nucleus-vacuole junction|endoplasmic reticulum
YGR134W CAF130 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.000753603222045368 0.965190788015539 1774 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter molecular_function CCR4-NOT core complex
YIL087C AIM19 hom FT MITOCHONDRION 0.000752568681619373 0.965238543568449 1775 Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth biological_process molecular_function mitochondrion
YML009C-A_d YML009C-A hom 0.000752053027731596 0.965262346780061 1776 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR088W GAA1 het FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000751341702497022 0.965295182470179 1777 Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER attachment of GPI anchor to protein GPI-anchor transamidase activity integral to membrane|GPI-anchor transamidase complex
YGL001C ERG26 het FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00075124004103624 0.965299875299111 1778 C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis ergosterol biosynthetic process C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity endoplasmic reticulum|endoplasmic reticulum membrane
YFR032C-B_p YFR032C-B hom 0.000750905544775833 0.965315316102132 1779 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YKL210W UBA1 het FT NUCLEUS 0.000750301983614954 0.965363839557116 1780 Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress protein ubiquitination ubiquitin activating enzyme activity nucleus|cytoplasm
YDR492W IZH1 hom FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000749898667798181 0.965361794993395 1781 Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process metal ion binding integral to membrane|endoplasmic reticulum|membrane
YER052C HOM3 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.00074951370703311 0.96540020591744 1782 Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process aspartate kinase activity cytoplasm
YCR090C_p YCR090C hom FT NUCLEUS 0.000749371479409028 0.9654119285446 1783 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene biological_process molecular_function nucleus|cytoplasm
YCR107W AAD3 hom FT OXIDATION-REDUCTION PROCESS 0.000748954405168923 0.965405383623061 1784 Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YER142C MAG1 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.000748890883954683 0.965408315864687 1785 3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress base-excision repair, AP site formation|DNA dealkylation involved in DNA repair alkylbase DNA N-glycosylase activity nucleus
YML009W-B_d YML009W-B hom 0.000748701013763795 0.965417080581498 1786 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Unknown Unknown Unknown
YBR203W COS111 hom FT SIGNALING|MITOCHONDRION 0.000748532949931512 0.965440297723054 1787 Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies signal transduction molecular_function mitochondrion
YIR008C PRI1 het FT NUCLEUS|CHROMOSOME 0.000748480460053253 0.965427261704723 1788 Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair lagging strand elongation|DNA replication, synthesis of RNA primer|DNA replication initiation|DNA replication single-stranded DNA binding|DNA primase activity alpha DNA polymerase:primase complex|nuclear replication fork
YDR160W SSY1 het FT PLASMA MEMBRANE 0.000748434218544092 0.965429396289806 1789 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes response to amino acid stimulus molecular_function integral to membrane|plasma membrane
YGL194C HOS2 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|NUCLEUS|CHROMOSOME 0.000747835526217162 0.965457032947149 1790 Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS negative regulation of meiosis|chromatin organization|regulation of transcription, DNA-dependent|positive regulation of stress-activated MAPK cascade|histone deacetylation NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity Rpd3L-Expanded complex|Set3 complex
YDR182W CDC1 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|ENDOPLASMIC RETICULUM 0.000747778902533461 0.965459646794963 1791 Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution DNA repair|cellular manganese ion homeostasis|dephosphorylation|actin cytoskeleton organization molecular_function integral to membrane|endoplasmic reticulum
YKL104C GFA1 het FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 0.000747300907769345 0.965497145521391 1792 Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication fungal-type cell wall chitin biosynthetic process glutamine-fructose-6-phosphate transaminase (isomerizing) activity cellular_component
YPL035C_d YPL035C hom 0.000747246190558717 0.965509962426552 1793 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene Unknown Unknown Unknown
YBR022W POA1 hom FT RNA PROCESSING 0.000747037749817628 0.965493859728763 1794 Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing tRNA splicing, via endonucleolytic cleavage and ligation phosphatase activity cellular_component
YGR158C MTR3 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000746960697498999 0.965497416605128 1795 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YGR031W IMO32 hom FT MITOCHONDRION 0.000746336540863781 0.965526228845587 1796 Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 biological_process molecular_function mitochondrion
YLR443W ECM7 hom FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS 0.000745979464576249 0.965542712176705 1797 Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency fungal-type cell wall organization|calcium ion transport molecular_function integral to membrane
YJL141C YAK1 hom FT PROTEIN PHOSPHORYLATION|NUCLEUS 0.000745398602899683 0.965569525905057 1798 Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose protein phosphorylation protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity nucleus|cytoplasm
YGR289C MAL11 hom FT CARBOHYDRATE METABOLISM|PLASMA MEMBRANE 0.000745192376502635 0.965599567502802 1799 Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization trehalose transport|maltose transport|disaccharide catabolic process trehalose transmembrane transporter activity|alpha-glucoside:hydrogen symporter activity|maltose:hydrogen symporter activity integral to membrane|plasma membrane
YLL032C YLL032C hom 0.000744265514547095 0.965642327916323 1800 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene biological_process molecular_function ribosome|cytoplasm
YNL120C_d YNL120C hom 0.000744141478061823 0.965627557416937 1801 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene Unknown Unknown Unknown
YFL018C LPD1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.000744077205529001 0.965630524376375 1802 Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes L-serine biosynthetic process|2-oxoglutarate metabolic process|leucine catabolic process|glycine catabolic process|isoleucine catabolic process|pyruvate metabolic process|valine catabolic process|hydrogen peroxide metabolic process glycine dehydrogenase (decarboxylating) activity|pyruvate dehydrogenase activity|oxoglutarate dehydrogenase (succinyl-transferring) activity|dihydrolipoyl dehydrogenase activity mitochondrial nucleoid|mitochondrion|glycine cleavage complex|mitochondrial oxoglutarate dehydrogenase complex
YIR022W SEC11 het FT PROTEIN LOCALIZATION|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000743261288930516 0.965668188896542 1803 18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum signal peptide processing|protein targeting to ER peptidase activity signal peptidase complex|endoplasmic reticulum
YCR075C ERS1 hom 0.000742413853522955 0.965707308475911 1804 Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains L-cystine transport|transmembrane transport L-cystine transmembrane transporter activity endosome|integral to membrane|fungal-type vacuole
YDL016C_d YDL016C het 0.000742391348629348 0.965708347355001 1805 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication Unknown Unknown Unknown
YNL292W PUS4 hom FT RNA PROCESSING|NUCLEUS|MITOCHONDRION 0.000742074113569365 0.965722991681496 1806 Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) tRNA modification pseudouridine synthase activity mitochondrion|nucleus
YBR002C RER2 het FF|FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000741833999987667 0.965759614630418 1807 Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting dolichol biosynthetic process|protein glycosylation|ER to Golgi vesicle-mediated transport dehydrodolichyl diphosphate synthase activity|prenyltransferase activity endoplasmic reticulum
YOR366W_d YOR366W hom 0.000741219104728628 0.965762460985017 1808 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C Unknown Unknown Unknown
YGR125W_p YGR125W hom 0.000741148048506408 0.965765741118152 1809 Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole biological_process molecular_function integral to membrane|fungal-type vacuole
YFL033C RIM15 hom FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS 0.000741042081800316 0.965801248912928 1810 Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|response to stress|regulation of meiosis protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YGR221C TOS2 hom FT CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.000740846096065001 0.965779680005364 1811 Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p budding cell bud growth molecular_function cellular bud neck|cellular bud tip
YOR192C THI72 hom 0.000740348326519207 0.965823046941913 1812 Transporter of thiamine or related compound; shares sequence similarity with Thi7p thiamine transport transporter activity integral to membrane|membrane
YPL209C IPL1 het FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.000740146945342563 0.965811954608378 1813 Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest spindle checkpoint|attachment of spindle microtubules to kinetochore|chromosome segregation|mitotic spindle disassembly|protein phosphorylation|meiotic sister chromatid segregation|homologous chromosome segregation|regulation of cytokinesis|mitotic cell cycle G2/M transition decatenation checkpoint protein kinase activity spindle microtubule|spindle midzone|chromosome passenger complex|condensed nuclear chromosome kinetochore|kinetochore microtubule|spindle
YFR033C QCR6 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.000740136906604613 0.965812418022856 1814 Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YJR065C ARP3 het FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.000740100735569048 0.965814087772841 1815 Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity mitochondrion inheritance|Arp2/3 complex-mediated actin nucleation|actin filament organization ATP binding Arp2/3 protein complex|plasma membrane
YKL053C-A MDM35 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|NUCLEUS|MITOCHONDRION 0.000739984294556722 0.965819462996752 1816 Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress mitochondrion organization|mitochondrial respiratory chain complex assembly molecular_function nucleus|cytoplasm|mitochondrial intermembrane space
YLR079W SIC1 hom FT CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.000739544780159675 0.965839752153281 1817 Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1 regulation of cyclin-dependent protein kinase activity|negative regulation of macroautophagy|G1/S transition of mitotic cell cycle cyclin-dependent protein kinase inhibitor activity nucleus|cytoplasm
YBR290W BSD2 hom FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM 0.000739341344107056 0.965849143311415 1818 Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification metal ion transport|ubiquitin-dependent protein catabolic process|protein targeting to vacuole protein binding fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YGL220W FRA2 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.000739301357339444 0.966014210233596 1819 Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel negative regulation of transcription from RNA polymerase II promoter in response to iron molecular_function cytosol|nucleus|cytoplasm
YAL013W DEP1 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.000739261717085228 0.965852819111286 1820 Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|regulation of DNA-dependent DNA replication initiation|Unknown molecular_function Rpd3L-Expanded complex|Rpd3L complex
YDR469W SDC1 hom FT CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS 0.000739097898466752 0.965860381426496 1821 Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30 histone H3-K4 methylation|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YMR267W PPA2 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.000738588825556175 0.965894050247054 1822 Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate aerobic respiration inorganic diphosphatase activity mitochondrion
YIR037W HYR1 hom FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS 0.000738282210663619 0.965918367670108 1823 Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor cellular response to oxidative stress phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity intracellular
YHL034C SBP1 hom FT TRANSLATION|NUCLEUS 0.000737992141288253 0.965911426280572 1824 Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11 negative regulation of translation|negative regulation of translation in response to stress RNA binding|eukaryotic initiation factor 4G binding nucleolus|cytoplasmic mRNA processing body|cytoplasm
YPL101W ELP4 hom FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS 0.000736818889029753 0.965965587049596 1825 Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification ATPase activity|tRNA binding Elongator holoenzyme complex|cytoplasm
YBR242W_p YBR242W hom FT NUCLEUS 0.000736655372600129 0.965973135460553 1826 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YJL052W TDH1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.000736571502543667 0.965987148036966 1827 Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress gluconeogenesis|glycolysis glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YBR025C OLA1 hom 0.000736536328727312 0.965978630886238 1828 P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress biological_process ATPase activity cytoplasm
YPR084W_p YPR084W hom 0.00073639157512118 0.966025884982433 1829 Putative protein of unknown function biological_process molecular_function cellular_component
YDR483W KRE2 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000736057558120551 0.966005798934053 1830 Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YPL166W ATG29 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS 0.000735883511763241 0.966018898348964 1831 Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy molecular_function pre-autophagosomal structure|cytoplasm
YOR135C_d IRC14 hom 0.000735793139094186 0.966012938806909 1832 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci Unknown Unknown Unknown
YNR012W URK1 hom FT NUCLEOTIDE METABOLISM|NUCLEUS 0.000735554268784759 0.966023965808885 1833 Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP pyrimidine-containing compound salvage uridine kinase activity nucleus|cytoplasm
YMR197C VTI1 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000734592334423304 0.96606837177892 1834 Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways Golgi to vacuole transport|vacuole fusion, non-autophagic|intra-Golgi vesicle-mediated transport|vesicle fusion SNAP receptor activity SNARE complex|integral to Golgi membrane
YDL167C NRP1 hom 0.000734192811312197 0.966086815075839 1835 Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis biological_process molecular_function cytoplasmic stress granule|cytoplasm
YDL059C RAD59 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.000733910381402928 0.966115010574523 1836 Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p DNA strand renaturation|telomere maintenance via recombination|double-strand break repair via break-induced replication|double-strand break repair via single-strand annealing protein binding nucleus
YGL003C CDH1 hom FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.000733757779243554 0.966116999815686 1837 Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p activation of mitotic anaphase-promoting complex activity|negative regulation of spindle pole body separation|positive regulation of mitotic metaphase/anaphase transition|Unknown|regulation of cell size anaphase-promoting complex binding|cyclin binding|ubiquitin-protein ligase activator activity nucleus|anaphase-promoting complex|cytoplasm
YOL068C HST1 hom FT CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.000732710969453101 0.966155221913576 1838 NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance chromatin silencing|negative regulation of mitotic recombination|histone deacetylation NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity Set3 complex
YCL063W VAC17 hom 0.000732257624936129 0.966176149881262 1839 Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p vacuole inheritance protein anchor fungal-type vacuole membrane
YBR196C-B_p YBR196C-B hom 0.000732247989088334 0.966176594705934 1840 Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YBR161W CSH1 hom FT LIPID METABOLISM 0.000732172766299859 0.966180067255146 1841 Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication glycosphingolipid biosynthetic process|sphingolipid biosynthetic process mannosyltransferase activity|transferase activity, transferring glycosyl groups integral to membrane|fungal-type vacuole
YHR132C ECM14 hom FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS 0.000731856974510986 0.96619464532485 1842 Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly fungal-type cell wall organization|proteolysis metalloendopeptidase activity fungal-type vacuole
YNR068C_p YNR068C hom 0.000731610202879066 0.96620603718702 1843 Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form biological_process molecular_function cellular_component
YBR107C IML3 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE 0.000730091311204954 0.966276154817272 1844 Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1 establishment of meiotic sister chromatid cohesion|ascospore formation|protein localization to chromosome, centromeric region|meiotic sister chromatid segregation|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome outer kinetochore
YBR151W APD1 hom FT NUCLEUS 0.000730035869188064 0.96627871422977 1845 Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus biological_process molecular_function nucleus|cytoplasm
YIL113W SDP1 hom FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION|NUCLEUS 0.000729972423332331 0.966281643130067 1846 Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock inactivation of MAPK activity involved in cell wall biogenesis|MAPK cascade involved in cell wall biogenesis MAP kinase tyrosine phosphatase activity nucleus|cytoplasm
YDR060W MAK21 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.000729762978606907 0.966291311892767 1847 Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein ribosomal large subunit assembly molecular_function Noc1p-Noc2p complex
YDR168W CDC37 het FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION 0.000729722746193869 0.966293169174074 1848 Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding regulation of stress-activated MAPK cascade|regulation of cell cycle|MAPK cascade involved in osmosensory signaling pathway|protein stabilization|spindle pole body duplication associated with nuclear envelope unfolded protein binding cytoplasm
YLR388W RPS29A hom FT TRANSLATION|RIBOSOME 0.000729643208707651 0.966296840927688 1849 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YGR129W SYF2 hom FT RNA PROCESSING|NUCLEUS 0.000729372012832915 0.966309360368615 1850 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest mRNA splicing, via spliceosome first spliceosomal transesterification activity|second spliceosomal transesterification activity U2-type post-mRNA release spliceosomal complex|Prp19 complex|U2-type prespliceosome|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YCR091W KIN82 hom FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION 0.000729272565570028 0.966313951237479 1851 Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p phospholipid translocation|protein phosphorylation|response to pheromone protein kinase activity cellular_component
YIR002C MPH1 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.000729158961112038 0.966344298811622 1852 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases negative regulation of strand invasion|recombinational repair|DNA replication, Okazaki fragment processing flap-structured DNA binding|3'-5' DNA helicase activity nucleus
YOL137W BSC6 hom FT GOLGI APPARATUS 0.000728950781006482 0.96632880606054 1853 Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression biological_process molecular_function COPI-coated vesicle|integral to membrane|clathrin-coated vesicle
YGR187C HGH1 hom 0.000728784830634096 0.966341483537051 1854 Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function cytoplasm
YGR196C FYV8 hom 0.000728601106074684 0.966344948424376 1855 Protein of unknown function, required for survival upon exposure to K1 killer toxin biological_process molecular_function cytoplasm
YBL032W HEK2 hom FT CHROMATIN ORGANIZATION|TRANSLATION|RNA LOCALIZATION|NUCLEUS|CHROMOSOME 0.000728356220182045 0.966356253324121 1856 RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K telomere maintenance via telomerase|intracellular mRNA localization|mRNA stabilization mRNA binding nuclear chromosome, telomeric region|cytoplasmic mRNA processing body|cytoplasm
YKL148C SDH1 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.000727848748395941 0.966379680247053 1857 Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits cellular respiration|mitochondrial electron transport, succinate to ubiquinone|tricarboxylic acid cycle succinate dehydrogenase (ubiquinone) activity|flavin adenine dinucleotide binding mitochondrial respiratory chain complex II|mitochondrion|mitochondrial membrane
YBR264C YPT10 hom FT PROTEIN LOCALIZATION|SIGNALING|PLASMA MEMBRANE 0.000724762314055815 0.966522162997864 1858 Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles Golgi organization GTPase activity|guanyl nucleotide binding cytoplasm
YEL013W VAC8 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.000724584623294889 0.966530365981028 1859 Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions piecemeal microautophagy of nucleus|vacuole inheritance|CVT vesicle assembly|vacuole fusion, non-autophagic|macroautophagy|nucleus-vacuole junction assembly protein anchor fungal-type vacuole membrane|nucleus-vacuole junction|Myo2p-Vac17p-Vac8p transport complex
YIL102C_p YIL102C hom 0.000723853403587561 0.966564122320053 1860 Putative protein of unknown function biological_process molecular_function cellular_component
YCL002C_p YCL002C hom 0.000723273812747978 0.966590878841788 1861 Putative protein of unknown function; YCL002C is not an essential gene biological_process molecular_function integral to membrane
YHR176W FMO1 hom FT OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000722499338345975 0.966626632124561 1862 Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins protein folding N,N-dimethylaniline monooxygenase activity endoplasmic reticulum membrane
YMR174C PAI3 hom 0.000722470141166916 0.966642901737328 1863 Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact vacuolar protein catabolic process endopeptidase inhibitor activity cytoplasm
YOL054W PSH1 hom FT PROTEOLYSIS|NUCLEUS|CHROMOSOME 0.000722217900870719 0.966639624583032 1864 E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity chromosome, centromeric region|nucleus
YIL025C_d YIL025C hom 0.000721907758708101 0.966653942193185 1865 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR363W ESC2 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS 0.000721588151747434 0.966668696753846 1866 Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member intra-S DNA damage checkpoint|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette|mitotic sister chromatid cohesion molecular_function nucleus
YBR072W HSP26 hom FT NUCLEUS 0.000720994498108124 0.966696102628509 1867 Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity protein folding|response to stress unfolded protein binding|mRNA binding nucleus|cytoplasm
YIL131C FKH1 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.000720925071422857 0.966699307696976 1868 Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication mRNA 3'-end processing|termination of RNA polymerase II transcription|donor selection|negative regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|cellular response to methylmercury|positive regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription elongation from RNA polymerase II promoter|Unknown|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle|chromatin remodeling RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|centromeric DNA binding nucleus
YDR260C SWM1 hom FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.000720807553174551 0.966704732903661 1869 Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation ascospore wall assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of mitotic metaphase/anaphase transition|protein ubiquitination molecular_function anaphase-promoting complex|nucleus
YOL077C BRX1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.000720804381335769 0.966704879330992 1870 Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif ribosomal large subunit assembly 5S rRNA binding|rRNA primary transcript binding nucleolus|preribosome, large subunit precursor
YIL098C FMC1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000719952970596297 0.966744184585641 1871 Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p mitochondrial proton-transporting ATP synthase complex assembly molecular_function mitochondrion|mitochondrial matrix
YCR082W AHC2 hom FT CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.000719933295102664 0.966745092902938 1872 Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex histone acetylation histone acetyltransferase activity Ada2/Gcn5/Ada3 transcription activator complex|nucleus|cytoplasm
YGL034C_d YGL034C hom 0.000719852295445029 0.966748832244899 1873 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL217W REE1 hom 0.000717296312646287 0.966866829337514 1874 Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle biological_process molecular_function cytoplasm
YHR095W_d YHR095W hom 0.000717277376019219 0.966867703550699 1875 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR102C EXO84 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|SITE OF POLARIZED GROWTH 0.000716368547386225 0.966909659853513 1876 Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate spliceosomal complex assembly|Golgi to plasma membrane transport|exocyst localization|exocytosis|exocyst assembly molecular_function incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip|exocyst
YNL191W DUG3 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.000716351723517884 0.966910436532497 1877 Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) glutathione catabolic process peptidase activity|omega peptidase activity|gamma-glutamyltransferase activity|carbon-nitrogen ligase activity, with glutamine as amido-N-donor cytoplasm
YDR222W_p YDR222W hom FT RESPONSE TO OXIDATIVE STRESS 0.000716068996701506 0.966923488706411 1878 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YDL071C_d YDL071C hom 0.000715868688387209 0.96695245165109 1879 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W Unknown Unknown Unknown
YPL128C TBF1 het FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|GENE SILENCING|NUCLEUS|CHROMOSOME 0.000715765833616842 0.966937484337028 1880 Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation telomere maintenance via telomere lengthening|negative regulation of chromatin silencing|snoRNA transcription from an RNA polymerase II promoter|negative regulation of telomere maintenance via telomerase RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|chromatin insulator sequence binding|telomeric DNA binding nuclear chromosome, telomeric region|nucleus
YHR205W SCH9 hom FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|CHROMOSOME 0.000715719925023228 0.966939603724315 1881 AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|regulation of protein localization|positive regulation of transcription from RNA polymerase III promoter|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase I promoter|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of cell size|regulation of response to osmotic stress protein serine/threonine kinase activity chromatin|fungal-type vacuole membrane|nucleus|cytoplasm
YHR010W RPL27A hom FT TRANSLATION|RIBOSOME 0.000714968663535789 0.966974286023254 1882 Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YKL193C SDS22 het FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS 0.000714380786893781 0.967011261533294 1883 Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function maintenance of protein location in nucleus|chromosome segregation protein serine/threonine phosphatase inhibitor activity|protein phosphatase type 1 activator activity protein phosphatase type 1 complex|nucleus|cytoplasm
YGR027C RPS25A hom FT TRANSLATION|RIBOSOME 0.000714226396113256 0.967008553168775 1884 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YLR081W GAL2 hom FT CARBOHYDRATE METABOLISM|PLASMA MEMBRANE 0.000714005750435249 0.967018739398217 1885 Galactose permease, required for utilization of galactose; also able to transport glucose galactose transport|galactose metabolic process galactose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YLR184W_d YLR184W hom 0.000713312784457368 0.967050730589825 1886 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR224C HTB1 het FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.000713078558554967 0.967061543781626 1887 Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|postreplication repair DNA binding replication fork protection complex|nuclear nucleosome
YML006C GIS4 hom FT SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.000712892772646353 0.967070120713775 1888 CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway cellular ion homeostasis|intracellular signal transduction molecular_function plasma membrane
YPL239W YAR1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS 0.000712318125774912 0.967096649699421 1889 Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock ribosomal small subunit biogenesis|cellular response to oxidative stress|response to osmotic stress molecular_function cytoplasm
YML088W UFO1 hom FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.000712301207622999 0.96709743073861 1890 F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|response to DNA damage stimulus ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex|nucleus|cytoplasm
YOR367W SCP1 hom FT CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.000711646388641035 0.967127660972925 1891 Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin actin filament organization|chronological cell aging actin filament binding|protein binding, bridging actin cortical patch
YJL019W MPS3 het FT CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON 0.000710511863717047 0.9671849283156 1892 Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p meiotic telomere clustering|synapsis|nuclear migration involved in conjugation with cellular fusion|spindle pole body duplication associated with nuclear envelope|telomere tethering at nuclear periphery|mitotic sister chromatid cohesion molecular_function nuclear envelope|nuclear periphery|integral to membrane|nuclear chromosome, telomeric region|half bridge of spindle pole body
YPR044C_d OPI11 hom 0.000710378051962178 0.967200887284205 1893 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YLL007C_p YLL007C hom 0.000710118455929294 0.967198199374175 1894 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene biological_process molecular_function cytoplasm
YNR062C_p YNR062C hom 0.000709533875713731 0.967225187118604 1895 Putative membrane protein of unknown function biological_process molecular_function integral to membrane
YDR405W MRP20 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.000709382624260764 0.967232169802966 1896 Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YML021C UNG1 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION 0.000709049816386264 0.967247534241671 1897 Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus DNA repair uracil DNA N-glycosylase activity mitochondrion|nucleus
YBR041W FAT1 hom FT KETONE METABOLISM|LIPID METABOLISM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.000708505949110649 0.967272642494105 1898 Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids very long-chain fatty acid metabolic process|long-chain fatty acid transport very long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity intrinsic to internal side of plasma membrane|integral to membrane|endoplasmic reticulum|lipid particle|peroxisome
YPR112C MRD1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000708450973624438 0.967275180501868 1899 Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|small-subunit processome assembly|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus|90S preribosome
YGR286C BIO2 hom FT KETONE METABOLISM|COFACTOR METABOLISM|MITOCHONDRION 0.000708073915630193 0.967321844203746 1900 Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant biotin biosynthetic process biotin synthase activity mitochondrion
YPR153W YPR153W hom 0.00070788852379307 0.96730114667666 1901 Putative protein of unknown function biological_process molecular_function integral to membrane
YIL024C_p YIL024C hom 0.000707414001308462 0.9673230536064 1902 Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p biological_process molecular_function cellular_component
YGL256W ADH4 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.000706742355792134 0.967368658459713 1903 Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency fermentation|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity mitochondrion
YLR176C RFX1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.000706700831589902 0.967355978033422 1904 Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus|cytoplasm
YNL094W APP1 hom FT CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.000706620885519413 0.967359668853389 1905 Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway actin cytoskeleton organization molecular_function actin cytoskeleton|actin cortical patch
YDR112W_d IRC2 hom 0.000706185411590662 0.967486889143072 1906 Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YGL160W AIM14 hom FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.000706149624384833 0.967386286299576 1907 NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p biological_process oxidoreductase activity, oxidizing metal ions integral to membrane|ribosome
YOR051C ETT1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEUS 0.000706004769990244 0.967388112695056 1908 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough translational termination molecular_function nucleus
YKR053C YSR3 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000705821268826656 0.96739658429289 1909 Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication phospholipid dephosphorylation|sphingolipid biosynthetic process sphingosine-1-phosphate phosphatase activity integral to membrane|endoplasmic reticulum
YLL021W SPA2 hom FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH 0.000705527770957919 0.967410134056081 1910 Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate regulation of initiation of mating projection growth|regulation of termination of mating projection growth|pseudohyphal growth|invasive filamentous growth|mating projection assembly cytoskeletal regulatory protein binding incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YER150W SPI1 hom 0.000705383648376751 0.967436215051558 1911 GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p response to acid molecular_function fungal-type cell wall
YDR457W TOM1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|PROTEOLYSIS|RNA LOCALIZATION|NUCLEUS 0.000705250255373583 0.967422945982126 1912 E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mitosis|nucleocytoplasmic transport|nucleus organization|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell size|protein ubiquitination ubiquitin-protein ligase activity integral to membrane|nucleolus|nucleus
YIL079C AIR1 hom FT RNA PROCESSING|NUCLEUS 0.000705152074151854 0.96742747866851 1913 Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent snRNA catabolic process polynucleotide adenylyltransferase activity nucleolus|TRAMP complex
YOR129C AFI1 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.000703806199768435 0.967489613125485 1914 Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p asymmetric protein localization|actin cortical patch localization|cellular bud site selection molecular_function nucleus|plasma membrane|cellular bud neck|cytoplasm
YLR434C_d YLR434C hom 0.000703696663796006 0.967494670038627 1915 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W Unknown Unknown Unknown
YBR018C GAL7 hom FT CARBOHYDRATE METABOLISM 0.000703547195965269 0.967501570475549 1916 Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism galactose catabolic process via UDP-galactose UDP-glucose:hexose-1-phosphate uridylyltransferase activity cytoplasm
YEL017C-A PMP2 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.000703108075238543 0.967565430320088 1917 Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication cation transport molecular_function membrane
YNL122C_p YNL122C hom FT TRANSLATION|MITOCHONDRION 0.000702794934013561 0.967550816017292 1918 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene biological_process molecular_function mitochondrion
YKL056C TMA19 hom FT TRANSLATION|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION|CYTOSKELETON 0.000702429533924141 0.967553169323911 1919 Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress cytoplasmic translation|cellular response to oxidative stress molecular_function cytosol|mitochondrion|ribosome|cytoplasm
YGR130C YGR130C hom 0.000702418709160923 0.967568177361835 1920 Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) biological_process molecular_function eisosome|membrane raft|cytoplasm
YDR481C PHO8 hom FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM 0.000701863157628452 0.967579317140941 1921 Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN nicotinamide nucleotide metabolic process|protein dephosphorylation nucleotide phosphatase activity|alkaline phosphatase activity fungal-type vacuole membrane
YGL192W IME4 hom FT CELL CYCLE|NUCLEUS 0.000701183100158451 0.967625196121001 1922 Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids meiosis|mRNA methylation mRNA (N6-adenosine)-methyltransferase activity cellular_component
YNL251C NRD1 het FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS 0.000701162633128135 0.967611658207991 1923 RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5, to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites mRNA 3'-end processing|nuclear mRNA surveillance|termination of RNA polymerase II transcription, exosome-dependent|antisense RNA transcript catabolic process|tRNA 3'-end processing|snRNA 3'-end processing|snoRNA 3'-end processing|CUT catabolic process RNA binding|transcription regulatory region RNA binding|protein domain specific binding Nrd1 complex|nucleus
YBR146W MRPS9 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.000701128165076522 0.967613249493565 1924 Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YKL063C_p YKL063C hom FT GOLGI APPARATUS 0.000700976873903234 0.967620234150451 1925 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi biological_process molecular_function Golgi apparatus
YLL053C_p YLL053C hom 0.000700924913872343 0.967622632988839 1926 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin biological_process molecular_function integral to membrane
YDR345C HXT3 hom FT PLASMA MEMBRANE 0.000700204305303167 0.967655901349867 1927 Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication hexose transport|transmembrane transport mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YER148W SPT15 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.000700031162614125 0.967668713809384 1928 TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability transposon integration|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|RNA polymerase II transcriptional preinitiation complex assembly|RNA polymerase III transcriptional preinitiation complex assembly RNA polymerase III regulatory region DNA binding|RNA polymerase I transcription factor recruiting transcription factor activity|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|RNA polymerase II activating transcription factor binding|DNA binding, bending|sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|TFIIIB-type transcription factor activity|chromatin binding|RNA polymerase I transcription factor binding transcription factor TFIIIB complex|RNA polymerase I upstream activating factor complex|nucleus|RNA polymerase I core factor complex|transcription factor TFIID complex
YBR223C TDP1 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.000700027703838975 0.967664054524431 1929 Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI DNA repair 3'-tyrosyl-DNA phosphodiesterase activity|5'-tyrosyl-DNA phosphodiesterase activity nucleus
YGR259C_d YGR259C hom 0.000699119533889052 0.967720422396876 1930 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W Unknown Unknown Unknown
YNL090W RHO2 hom FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE 0.000698624050410881 0.967728857229686 1931 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly microtubule-based process|fungal-type cell wall organization|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction GTPase activity membrane
YFL012W_p YFL012W hom 0.000698595277668343 0.967730185587987 1932 Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin biological_process molecular_function cellular_component
YJR010C-A SPC1 hom FT PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00069856327322836 0.967731663144967 1933 Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress signal peptide processing|protein targeting to ER molecular_function signal peptidase complex
YLR392C ART10 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION 0.000698445443701071 0.967737103011156 1934 Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene biological_process molecular_function cytoplasm
YHR058C MED6 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.000697340201855465 0.967807335263642 1935 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly core mediator complex
YER180C ISC10 hom FT CELL CYCLE 0.00069731630392707 0.967794032682678 1936 Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells sporulation resulting in formation of a cellular spore molecular_function cellular_component
YIL041W GVP36 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000697280576800397 0.967810086357111 1937 BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis vacuole organization|endocytosis|establishment or maintenance of actin cytoskeleton polarity molecular_function integral to Golgi membrane|cytoplasm
YCR053W THR4 hom FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|AMINO ACID METABOLISM|NUCLEUS 0.000697233829108533 0.967826653280688 1938 Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway endocytosis|threonine metabolic process threonine synthase activity nucleus|cytoplasm
YAR029W_p YAR029W hom 0.000696809914299289 0.967812611073923 1939 Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YGL178W MPT5 hom FT TRANSLATION 0.000696749127510258 0.967825010981384 1940 mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity negative regulation of translation|negative regulation of translational initiation|Unknown mRNA binding|protein binding, bridging cytoplasm
YNL193W_p YNL193W hom 0.000696317215767879 0.967835357717372 1941 Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis biological_process molecular_function cellular_component
YDL178W DLD2 hom FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.000696150457372815 0.967843056536086 1942 D-lactate dehydrogenase, located in the mitochondrial matrix lactate metabolic process actin binding|D-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial matrix
YHR181W SVP26 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.000696003660575775 0.967849833780142 1943 Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment protein retention in Golgi apparatus|fungal-type cell wall organization|protein glycosylation|ER to Golgi vesicle-mediated transport COPII adaptor activity integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum|integral to Golgi membrane|ER to Golgi transport vesicle
YBL077W_d YBL077W het 0.00069579544331887 0.967864236514101 1944 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C Unknown Unknown Unknown
YML117W NAB6 hom 0.000694236269446434 0.967964899009519 1945 Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP biological_process molecular_function cytoplasm
YGR043C NQM1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|NUCLEUS 0.000693355741942472 0.96797208201453 1946 Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift biological_process sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity nucleus
YPL106C SSE1 hom 0.000693260610083316 0.967976474044854 1947 ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication protein folding|protein refolding peptide binding|adenyl-nucleotide exchange factor activity|ATP binding polysome|cytoplasm
YNR061C YNR061C hom 0.000693163544754116 0.967980955340271 1948 Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress biological_process molecular_function integral to membrane|fungal-type vacuole
YLR458W_d YLR458W het 0.000693131827060882 0.967982419677494 1949 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis Unknown Unknown Unknown
YGL089C MF(ALPHA)2 hom FT SIGNALING 0.000692583052459888 0.968007755429718 1950 Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2 pheromone-dependent signal transduction involved in conjugation with cellular fusion mating pheromone activity extracellular region
YMR115W MGR3 hom FT PROTEOLYSIS|MITOCHONDRION 0.000692426229387896 0.968014995622218 1951 Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA misfolded or incompletely synthesized protein catabolic process misfolded protein binding mitochondrion|mitochondrial inner membrane|i-AAA complex
YMR295C YMR295C hom FT SITE OF POLARIZED GROWTH 0.000692320645474503 0.9680246361853 1952 Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function ribosome|cellular bud|mating projection tip
YOR055W_d YOR055W hom 0.00069136777959349 0.968063862099378 1953 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR147W MDM32 hom FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION 0.000690871096427892 0.968086792993638 1954 Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34 mitochondrion inheritance|cellular ion homeostasis|mitochondrion organization molecular_function mitochondrion|mitochondrial inner membrane
YDR141C DOP1 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS 0.000689912089292005 0.968131068559652 1955 Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies endoplasmic reticulum organization|cell morphogenesis|Golgi to endosome transport molecular_function trans-Golgi network|endosome|mitochondrion|cytoplasm
YBR133C HSL7 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH 0.000689375445552372 0.968155844440384 1956 Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress G2/M transition of mitotic cell cycle|regulation of cell cycle protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity cellular bud neck
YAR030C_d YAR030C hom 0.000689208798398777 0.968163538247378 1957 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 Unknown Unknown Unknown
YIL054W_p YIL054W hom 0.000689174739442619 0.968165110690052 1958 Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YDR003W-A_p YDR003W-A hom 0.000688871968582647 0.968179089098661 1959 Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YPL093W NOG1 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000688838309875846 0.968180643063727 1960 Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|rRNA processing GTP binding nucleolus|preribosome, large subunit precursor
YJL093C TOK1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.000688789104875661 0.968182914774853 1961 Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin cellular potassium ion homeostasis potassium channel activity integral to membrane|plasma membrane
YNL077W APJ1 hom FT NUCLEUS|MITOCHONDRION 0.000688417372214301 0.968200077047584 1962 Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress biological_process unfolded protein binding mitochondrion|nucleus|cytoplasm
YFR057W_p YFR057W hom 0.000687446893993932 0.968249614942492 1963 Putative protein of unknown function biological_process molecular_function cellular_component
YOR013W_d IRC11 hom 0.000686920896832504 0.968283355652971 1964 Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci Unknown Unknown Unknown
YOL106W_d YOL106W hom 0.000686341887164211 0.968310075737679 1965 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR259C TRM732 hom 0.0006863126771642 0.96829724756108 1966 Interacts with Trm7p for 2'-O-methylation of C32 of substrate tRNAs; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene biological_process molecular_function cytoplasm
YAL047C SPC72 hom FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CYTOSKELETON 0.000685816451092255 0.968320157619518 1967 Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization microtubule nucleation|nuclear migration along microtubule|mitotic cell cycle spindle orientation checkpoint|mitotic spindle elongation|mitotic sister chromatid segregation structural constituent of cytoskeleton outer plaque of spindle pole body
YCL010C SGF29 hom FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.000685144928124026 0.968351160930231 1968 Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation histone H3-K14 acetylation|cellular protein complex localization|histone H3-K18 acetylation|cellular protein localization|histone H3-K9 acetylation|positive regulation of transcription from RNA polymerase II promoter methylated histone residue binding|RNA polymerase II transcription factor recruiting transcription factor activity Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YNL123W NMA111 hom FT LIPID METABOLISM|PROTEOLYSIS|NUCLEUS 0.000683952053057409 0.968406234482796 1969 Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases apoptotic process|cellular lipid metabolic process|protein catabolic process|cellular response to heat serine-type peptidase activity nucleus
YOR021C SFM1 hom 0.000683593333420417 0.968422796150056 1970 SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism peptidyl-arginine methylation protein-arginine omega-N monomethyltransferase activity cellular_component
YDL165W CDC36 het FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|NUCLEUS 0.000683024856434779 0.968449042097339 1971 Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor response to pheromone involved in conjugation with cellular fusion|regulation of cell cycle|deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination ubiquitin-protein ligase activity CCR4-NOT core complex|nucleus|cytoplasm
YHR113W APE4 hom FT PROTEOLYSIS 0.000682755558140497 0.968461475310631 1972 Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family proteolysis aminopeptidase activity fungal-type vacuole lumen|ribosome|cytoplasm
YOR265W RBL2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.000681961477055283 0.968498137226894 1973 Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress tubulin complex assembly|tubulin complex biogenesis tubulin binding|beta-tubulin binding cytoplasm
YOR295W UAF30 hom FT CHROMATIN ORGANIZATION|NUCLEUS 0.000681414915893278 0.968537446588686 1974 Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication transcription of nuclear large rRNA transcript from RNA polymerase I promoter|chromatin organization RNA polymerase I upstream control element sequence-specific DNA binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity nucleolus|RNA polymerase I upstream activating factor complex
YNL031C HHT2 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.000681230234676643 0.968531898002831 1975 Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint DNA binding nuclear nucleosome
YER053C-A YER053C-A hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000680961947304424 0.968544284593739 1976 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress biological_process molecular_function endoplasmic reticulum
YPL138C SPP1 hom FT CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS 0.000680841272880347 0.96854985602774 1977 Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein histone H3-K4 methylation|regulation of transcription, DNA-dependent|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific)|chromatin binding|methylated histone residue binding Set1C/COMPASS complex
YDR385W EFT2 hom FT TRANSLATION|NUCLEOTIDE METABOLISM|RIBOSOME 0.000680764401177239 0.968553405128722 1978 Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication translational elongation|positive regulation of translational elongation translation elongation factor activity ribosome
YDR144C MKC7 hom FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS|PLASMA MEMBRANE 0.0006800199358437 0.968587776490546 1979 GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p proteolysis|fungal-type cell wall organization aspartic-type endopeptidase activity fungal-type cell wall
YAL020C ATS1 hom FT RNA PROCESSING|CELL DIVISION|CYTOSKELETON ORGANIZATION 0.000679457085597259 0.968613762869533 1980 Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle microtubule-based process|budding cell bud growth|microtubule cytoskeleton organization|tRNA wobble uridine modification molecular_function cytoplasm
YNL116W DMA2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION 0.000679102699849552 0.96863012461411 1981 Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint ubiquitin-protein ligase activity cytoplasm
YKR003W OSH6 hom FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.000678904168687253 0.96863929066617 1982 Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion sterol homeostasis|maintenance of cell polarity|endocytosis|sterol transport|exocytosis|sterol metabolic process phosphatidic acid binding|lipid binding|phosphatidylinositol-3,4-bisphosphate binding|oxysterol binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-4-phosphate binding cortical endoplasmic reticulum|extrinsic to membrane|cytoplasm
YJL025W RRN7 het FT NUCLEUS 0.000678877424199983 0.968659223928593 1983 Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p transcription initiation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter TBP-class protein binding|RNA polymerase I CORE element sequence-specific DNA binding|RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity nucleolus|RNA polymerase I core factor complex
YLR445W GMC2 hom FT CELL CYCLE 0.00067849852528968 0.968662689935364 1984 Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor meiosis|synaptonemal complex organization molecular_function cellular_component
YPR071W_p YPR071W hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000678362625535383 0.968664293375288 1985 Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C biological_process molecular_function integral to membrane
YPL117C IDI1 het FT LIPID METABOLISM|NUCLEUS 0.000678265111041451 0.968668795561845 1986 Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability farnesyl diphosphate biosynthetic process isopentenyl-diphosphate delta-isomerase activity nucleus|cytoplasm
YIL062C ARC15 het FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|MITOCHONDRION|CYTOSKELETON 0.000677368837483211 0.968710176029091 1987 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity mitochondrion inheritance|actin cortical patch assembly mRNA binding|structural molecule activity Arp2/3 protein complex|extrinsic to mitochondrial outer membrane
YLR404W FLD1 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000677021473545033 0.968726213657596 1988 Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy lipid particle organization molecular_function integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum
YDR328C SKP1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|ION HOMEOSTASIS|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|NUCLEUS|CHROMOSOME|UBIQUITIN LIGASE COMPLEX|KINETOCHORE 0.000676754755740337 0.968738527900895 1989 Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress kinetochore assembly|protein complex assembly|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein complex assembly|G1/S transition of mitotic cell cycle|septin ring assembly|regulation of exit from mitosis|G2/M transition of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein neddylation|vacuolar acidification|cytokinesis ubiquitin-protein ligase activity|DNA replication origin binding|protein binding RAVE complex|SCF ubiquitin ligase complex|nucleus|CBF3 complex|kinetochore|cytoplasm
YNL250W RAD50 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION 0.000676736098050066 0.96875336797279 1990 Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress base-excision repair|meiotic DNA double-strand break processing|telomere maintenance via recombination|meiosis|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|negative regulation of endodeoxyribonuclease activity double-stranded DNA binding|single-stranded telomeric DNA binding|ATPase activity|double-stranded telomeric DNA binding|G-quadruplex DNA binding|telomeric DNA binding|adenylate kinase activity mitochondrion|nucleus|Mre11 complex
YOR358W HAP5 hom FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS 0.00067658979620038 0.968746144013762 1991 Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration RNA polymerase II core promoter proximal region sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription CCAAT-binding factor complex
YPL232W SSO1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PLASMA MEMBRANE 0.000676422755557876 0.968753856213165 1992 Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p ascospore formation|ascospore-type prospore assembly|vesicle fusion phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|SNAP receptor activity SNARE complex|fungal-type vacuole membrane|plasma membrane|prospore membrane
YLR243W GPN3 het FT PROTEIN LOCALIZATION 0.000676219664094288 0.968763232868439 1993 Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p biological_process signal sequence binding cellular_component
YPR196W_p YPR196W hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.000676024876162602 0.968772226156873 1994 Putative maltose-responsive transcription factor regulation of transcription, DNA-dependent sequence-specific DNA binding cellular_component
YKR104W YKR104W hom FT NUCLEOTIDE METABOLISM 0.000675962364869491 0.968775112281534 1995 Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YMR305C SCW10 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOPLASMIC RETICULUM 0.000675670382489195 0.968788593011891 1996 Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p conjugation with cellular fusion glucosidase activity fungal-type cell wall|extracellular region|endoplasmic reticulum|cytoplasm
YBR292C_d YBR292C hom 0.000675444825181189 0.968799006924635 1997 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene Unknown Unknown Unknown
YDL025C RTK1 hom FT PROTEIN PHOSPHORYLATION 0.000675352763784834 0.968803257373011 1998 Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress biological_process protein serine/threonine kinase activity|protein kinase activity cellular_component
YHR046C INM1 hom FT LIPID METABOLISM|CARBOHYDRATE METABOLISM|NUCLEUS 0.000674487174405305 0.968843221430745 1999 Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate inositol phosphate dephosphorylation inositol monophosphate 1-phosphatase activity nucleus|cytoplasm
YLR194C YLR194C hom FT CELL WALL ORG/BIOGENESIS|PLASMA MEMBRANE 0.000673630237705062 0.96890598053548 2000 Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress fungal-type cell wall organization structural constituent of cell wall fungal-type cell wall|anchored to plasma membrane
YLR361C-A_p YLR361C-A hom 0.000673275482467216 0.968899165093418 2001 Putative protein of unknown function biological_process molecular_function cellular_component
YOR053W_d YOR053W hom 0.000672849607323126 0.968951267255067 2002 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C Unknown Unknown Unknown
YPR009W SUT2 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.000672615907396351 0.968948143941933 2003 Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|sequence-specific DNA binding nucleus
YLR092W SUL2 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.000672121383650078 0.968952449831273 2004 High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates sulfate transport sulfate transmembrane transporter activity integral to membrane|plasma membrane
YNL288W CAF40 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.00067199291070691 0.968958381435129 2005 Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter molecular_function CCR4-NOT core complex
YMR055C BUB2 hom FT CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON 0.00067197423532478 0.968959243678838 2006 Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint GTPase activator activity spindle pole body
YNL139C THO2 hom FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|NUCLEUS 0.000671902796655467 0.968962542007569 2007 Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|DNA recombination|transcription elongation from RNA polymerase II promoter DNA binding|nucleic acid binding THO complex part of transcription export complex|nucleus|nucleoplasmic THO complex
YNL332W THI12 hom 0.000671873638466752 0.968968513675066 2008 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 thiamine biosynthetic process molecular_function cellular_component
YBR063C_p YBR063C hom 0.000671079789554691 0.969000540345521 2009 Putative protein of unknown function; YBR063C is not an essential gene biological_process molecular_function cellular_component
YBR095C RXT2 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.000670906363154619 0.969031648287787 2010 Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth conjugation with cellular fusion|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|invasive growth in response to glucose limitation histone deacetylase activity Rpd3L-Expanded complex|nucleus|Rpd3L complex
YGR206W MVB12 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT 0.000669107717303975 0.96909159144729 2011 ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin negative regulation of protein complex assembly|protein targeting to vacuole|endosome transport via multivesicular body sorting pathway ubiquitin binding cytosol|endosome|ESCRT I complex
YHR110W ERP5 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000669085605327895 0.969092612365408 2012 Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport vesicle-mediated transport molecular_function integral to membrane
YJR066W TOR1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS|PLASMA MEMBRANE 0.000669016524647006 0.969095801846334 2013 PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication regulation of cell cycle|G1 phase of mitotic cell cycle|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell growth|response to DNA damage stimulus|mitochondria-nucleus signaling pathway|ribosome biogenesis|meiosis|signal transduction|TOR signaling cascade|fungal-type cell wall organization|negative regulation of autophagy protein binding|protein kinase activity TORC1 complex|fungal-type vacuole membrane|endosome membrane|extrinsic to internal side of plasma membrane|plasma membrane|nucleus|Golgi membrane|cytoplasm
YDR081C PDC2 het FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS 0.000668672194469458 0.969111699707047 2014 Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions positive regulation of thiamine biosynthetic process|Unknown|positive regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding nucleus
YAL029C MYO4 hom FT RNA LOCALIZATION|MITOCHONDRION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.000668476926699567 0.969120715302795 2015 Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization microfilament motor activity|actin filament binding mitochondrion|filamentous actin|myosin V complex|cellular bud|cellular bud tip
YGR283C YGR283C hom FT NUCLEUS 0.00066835167085017 0.969126498420559 2016 Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus biological_process S-adenosylmethionine-dependent methyltransferase activity ribosome|nucleolus
YMR079W SEC14 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000667628471238958 0.969159888897031 2017 Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs Golgi vesicle budding|phosphatidylinositol metabolic process|Golgi to plasma membrane protein transport|Golgi to vacuole transport|ascospore formation|Unknown|phospholipid transport phosphatidylinositol transporter activity|phosphatidylcholine transporter activity cytosol|Golgi apparatus|Golgi membrane|cytoplasm
YBR162W-A YSY6 hom FT PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00066722778152895 0.969178388958363 2018 Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion protein secretion molecular_function endoplasmic reticulum
YML018C YML018C hom 0.000667123496894098 0.969206174596746 2019 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YLR047C FRE8 hom FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.000667113824160412 0.969183650434932 2020 Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p cellular metal ion homeostasis oxidoreductase activity, oxidizing metal ions integral to membrane|membrane
YDL014W NOP1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000666790222391062 0.969198591320123 2021 Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin box C/D snoRNA 3'-end processing|rRNA processing|snoRNA processing|rRNA methylation rRNA methyltransferase activity small-subunit processome|box C/D snoRNP complex|ribosome|nucleolus|90S preribosome
YGL169W SUA5 het FT RNA PROCESSING|TRANSLATION|NUCLEUS|CHROMOSOME 0.00066628584740944 0.969244820591061 2022 Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family threonylcarbamoyladenosine metabolic process|telomere maintenance|regulation of translational fidelity single-stranded telomeric DNA binding cytoplasm
YMR178W YMR178W hom FT COFACTOR METABOLISM|NUCLEUS 0.000666164554883602 0.969227478789839 2023 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YBR232C_d YBR232C hom 0.000666026806508146 0.969233838726018 2024 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL184C STR3 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.000666011169606438 0.969234560692528 2025 Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p methionine biosynthetic process|transsulfuration cystathionine beta-lyase activity peroxisome
YFL015C_d YFL015C hom 0.000665425228046478 0.969261614035652 2026 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene Unknown Unknown Unknown
YDL081C RPP1A hom FT TRANSLATION|RIBOSOME 0.000665405877363527 0.9692625074712 2027 Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component cytoplasmic translation|translational elongation structural constituent of ribosome cytosolic large ribosomal subunit
YNL242W ATG2 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION 0.00066520797417488 0.969271644812099 2028 Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress mitochondrion degradation|piecemeal microautophagy of nucleus|peroxisome degradation|CVT pathway|autophagic vacuole assembly molecular_function pre-autophagosomal structure|cytoplasm|extrinsic to membrane
YHL007C STE20 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH 0.000664732132748137 0.969293614789567 2029 Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p negative regulation of gene expression|osmosensory signaling pathway via Sho1 osmosensor|activation of MAPKKK activity|vacuole inheritance|protein phosphorylation|cellular bud site selection|cellular response to heat|regulation of exit from mitosis|pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|pseudohyphal growth|sterol import|stress granule assembly|invasive growth in response to glucose limitation|positive regulation of apoptotic process histone serine kinase activity|MAP kinase kinase kinase kinase activity|protein kinase activity incipient cellular bud site|plasma membrane|nucleus|mating projection tip
YDL221W_d YDL221W het 0.000664633141351298 0.969302760963577 2030 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13 Unknown Unknown Unknown
YKL136W_d YKL136W hom 0.000664241179975015 0.969316282494341 2031 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C Unknown Unknown Unknown
YFL038C YPT1 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS 0.00066347147234953 0.969351820596284 2032 Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) Golgi vesicle budding|Golgi vesicle docking|early endosome to Golgi transport|macroautophagy|endocytic recycling|protein complex assembly|CVT pathway|retrograde vesicle-mediated transport, Golgi to ER|SNARE complex disassembly|ER to Golgi vesicle-mediated transport|COPII-coated vesicle budding SNARE binding|GTPase activity trans-Golgi network|mitochondrion|Golgi stack|endoplasmic reticulum membrane|Golgi membrane|pre-autophagosomal structure
YOR226C ISU2 hom FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM|MITOCHONDRION 0.000663464085487469 0.969352161654726 2033 Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification molecular_function mitochondrial matrix
YNL073W MSK1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION|MITOCHONDRION 0.000662894331426539 0.969378467758139 2034 Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys) tRNA import into mitochondrion|lysyl-tRNA aminoacylation|mitochondrial lysyl-tRNA aminoacylation|mitochondrial translation lysine-tRNA ligase activity mitochondrion
YJR055W HIT1 hom FT NUCLEUS 0.000662823351590147 0.969381744969087 2035 Protein of unknown function, required for growth at high temperature biological_process molecular_function nucleus|cytoplasm
YFL013C IES1 hom FT CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.000662096401062408 0.969451793890976 2036 Subunit of the INO80 chromatin remodeling complex nucleosome mobilization molecular_function nucleus|Ino80 complex
YJR004C SAG1 hom 0.000662092937779031 0.969415468944655 2037 Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor agglutination involved in conjugation with cellular fusion cell adhesion molecule binding fungal-type cell wall
YGR144W THI4 hom FT MITOCHONDRION ORGANIZATION|NUCLEUS 0.000661690507533421 0.969434049596647 2038 Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents thiamine biosynthetic process|mitochondrial genome maintenance|thiazole biosynthetic process ferrous iron binding cytosol
YJR088C EMC2 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000661262984515664 0.969453788828004 2039 Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YJL071W ARG2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION 0.000661153349081383 0.969458850825606 2040 Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p arginine biosynthetic process|ornithine biosynthetic process acetyl-CoA:L-glutamate N-acetyltransferase activity mitochondrial matrix
YJL136C RPS21B hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.000660686362137634 0.969480412178603 2041 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YHR149C SKG6 hom FT SITE OF POLARIZED GROWTH 0.000660618708149406 0.969483535847059 2042 Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p biological_process molecular_function cell cortex|incipient cellular bud site|integral to membrane|cellular bud neck|cellular bud tip
YDR169C-A_p YDR169C-A hom 0.000660566228354142 0.969485958904548 2043 Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YMR169C ALD3 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 0.000660387233748712 0.969494223310462 2044 Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose beta-alanine biosynthetic process|polyamine catabolic process aldehyde dehydrogenase (NAD) activity cytoplasm
YDL084W SUB2 het FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.000660071594100888 0.969508796797714 2045 Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|mRNA splicing, via spliceosome|transcription elongation from RNA polymerase II promoter|chromatin silencing at telomere ATP-dependent RNA helicase activity chromosome, telomeric region|nucleus|transcription export complex|spliceosomal complex
YPL125W KAP120 hom FT PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.000659839186431486 0.969519527364308 2046 Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p protein import into nucleus|transcription factor import into nucleus protein transporter activity|structural constituent of nuclear pore integral to membrane|nucleus|nuclear pore|cytoplasm
YER056C-A RPL34A hom FT TRANSLATION|RIBOSOME 0.000659628254157765 0.969529266388522 2047 Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YER185W PUG1 hom FT PLASMA MEMBRANE 0.000659136172147808 0.969551986488437 2048 Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins heme transport molecular_function integral to membrane|plasma membrane
YGR249W MGA1 hom FT NUCLEUS 0.000659047818652919 0.969556065892842 2049 Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants filamentous growth sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YOR337W TEA1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0006588077857728 0.969580757423862 2050 Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein transcription, DNA-dependent sequence-specific DNA binding|DNA binding nucleus
YLR064W PER33 hom FT PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|NUCLEAR PORE 0.000658681462871877 0.96959112410575 2051 Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress biological_process molecular_function integral to membrane|endoplasmic reticulum|nuclear pore
YGL129C RSM23 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.000658079123474519 0.96960079195597 2052 Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YKL213C DOA1 hom FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS 0.000657854347139616 0.969670100840763 2053 WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process ubiquitin binding nucleus|cytoplasm
YHR051W COX6 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.000657811608320073 0.969613143535984 2054 Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YNL293W MSB3 hom FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH 0.000657048835406416 0.969652885478564 2055 Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress actin filament organization|exocytosis Rab GTPase activator activity incipient cellular bud site|polarisome|cellular bud tip
YKR038C KAE1 het FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|PROTEOLYSIS|NUCLEUS|CHROMOSOME 0.000656810744575407 0.969659354996159 2056 Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription chromosome organization|threonylcarbamoyladenosine metabolic process|telomere maintenance|positive regulation of transcription from RNA polymerase II promoter chromatin DNA binding nuclear chromatin|EKC/KEOPS complex|nucleus|cytoplasm
YMR313C TGL3 hom FT LIPID METABOLISM|CELL DIVISION 0.000656762882273099 0.969661564876818 2057 Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation triglyceride catabolic process|cell budding|cellular lipid metabolic process triglyceride lipase activity|lysophosphatidylethanolamine acyltransferase activity lipid particle
YIL085C KTR7 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|GOLGI APPARATUS 0.0006566831980674 0.96966524402724 2058 Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication fungal-type cell wall organization|protein N-linked glycosylation mannosyltransferase activity Golgi apparatus
YDL111C RRP42 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000655966589090826 0.969698331067578 2059 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7) nuclear polyadenylation-dependent tRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nonfunctional rRNA decay|nuclear polyadenylation-dependent mRNA catabolic process|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing molecular_function nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YDL009C_p YDL009C hom 0.000655961702265636 0.969698556700686 2060 Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene biological_process molecular_function cellular_component
YOR316C COT1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION 0.000655720344803435 0.969709700592051 2061 Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication cellular zinc ion homeostasis|cobalt ion transport|zinc ion transport cobalt ion transmembrane transporter activity|zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity mitochondrion|integral to membrane|fungal-type vacuole
YOL073C YOL073C hom 0.000655582425876619 0.969716068550035 2062 Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2 biological_process molecular_function integral to membrane
YGR099W TEL2 het FT PROTEIN LOCALIZATION|NUCLEUS|CHROMOSOME 0.000655327632555502 0.969741369896352 2063 Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1 protein localization to chromosome|telomere maintenance via telomerase|telomere maintenance telomeric DNA binding ASTRA complex|nuclear telomere cap complex
YGL028C SCW11 hom FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM 0.000655253145072763 0.969731272028255 2064 Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p cytokinesis, completion of separation glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall
YKR096W ESL2 hom FT NUCLEUS 0.000655156847489983 0.969753764362376 2065 Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain biological_process molecular_function ribosome|nucleus|cytoplasm
YFL034C-A RPL22B hom FT TRANSLATION|RIBOSOME 0.000655131044122887 0.969736909648276 2066 Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YFL024C EPL1 het FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.000654923546268003 0.969832274963056 2067 Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb DNA repair|histone acetylation|regulation of transcription from RNA polymerase II promoter histone acetyltransferase activity Piccolo NuA4 histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YOL049W GSH2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.000654396791436603 0.969775316734035 2068 Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock glutathione biosynthetic process glutathione synthase activity intracellular
YKL069W YKL069W hom FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS 0.00065425049329935 0.969782070588741 2069 Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress cellular response to oxidative stress methionine-R-sulfoxide reductase activity nucleus|cytoplasm
YNR003C RPC34 het FT NUCLEUS|MITOCHONDRION 0.000654143790486889 0.969782492976224 2070 RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity mitochondrion|DNA-directed RNA polymerase III complex|nucleus|cytoplasm
YGR073C_d YGR073C het 0.000653183845937941 0.969826815487689 2071 Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein Unknown Unknown Unknown
YNL281W HCH1 hom FT NUCLEOTIDE METABOLISM|NUCLEUS 0.000653167851428468 0.969827553986166 2072 Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress protein folding|response to stress ATPase activator activity|chaperone binding nucleus|cytoplasm
YGR208W SER2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.000653092209152334 0.969849035855181 2073 Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source L-serine biosynthetic process phosphoserine phosphatase activity nucleus|cytoplasm
YLL010C PSR1 hom FT PLASMA MEMBRANE 0.000652348131252334 0.969865402140006 2074 Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p response to stress phosphoprotein phosphatase activity plasma membrane
YKL121W_p DGR2 hom 0.000651438298387644 0.969907411060059 2075 Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds biological_process molecular_function cellular_component
YMR085W_p YMR085W hom FT CARBOHYDRATE METABOLISM 0.000650690265888701 0.96995539080591 2076 Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 biological_process molecular_function cellular_component
YLR271W_p YLR271W hom FT NUCLEUS 0.000650372512309979 0.970059775847654 2077 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS biological_process molecular_function nucleus|cytoplasm
YER008C SEC3 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH 0.000650082319048883 0.969983448557244 2078 Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress exocytosis|Golgi to plasma membrane transport|endoplasmic reticulum inheritance|exocyst localization|exocyst assembly|vesicle fusion|vesicle docking involved in exocytosis Rho GTPase binding|phosphatidylinositol-4,5-bisphosphate binding incipient cellular bud site|cellular bud neck|mating projection tip|exocyst|cellular bud tip
YMR113W FOL3 het FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM 0.000649644242669131 0.969990246675881 2079 Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis folic acid-containing compound biosynthetic process dihydrofolate synthase activity cytoplasm
YOL138C RTC1 hom 0.000649634797283906 0.969990682791567 2080 Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif biological_process molecular_function ribosome|fungal-type vacuole|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YCR081W SRB8 hom FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.000649502987487533 0.970010185700744 2081 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity mediator complex
YAL041W CDC24 het FT CELL CYCLE|SIGNALING|NUCLEUS|SITE OF POLARIZED GROWTH 0.000649088402804039 0.970015911127062 2082 Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress regulation of exit from mitosis|establishment of cell polarity|small GTPase mediated signal transduction Rho guanyl-nucleotide exchange factor activity incipient cellular bud site|nucleus|cellular bud neck|mating projection tip|cellular bud tip|cytoplasm
YDR138W HPR1 hom FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|NUCLEUS|RNA POL II, HOLOENZYME 0.000648348627321581 0.970050068372169 2083 Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|DNA recombination|response to DNA damage stimulus|transcription elongation from RNA polymerase II promoter protein complex scaffold|nucleic acid binding THO complex part of transcription export complex|Cdc73/Paf1 complex|nucleoplasmic THO complex
YPL030W TRM44 hom FT RNA PROCESSING 0.000647995745375674 0.970070823097701 2084 tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene tRNA methylation tRNA (uracil) methyltransferase activity cytoplasm
YML072C TCB3 hom FT ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE 0.00064789936465896 0.97007081195597 2085 Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact biological_process lipid binding mitochondrion|cortical endoplasmic reticulum|cellular bud
YIL015W BAR1 hom FT SIGNALING|PROTEOLYSIS 0.000647786229905647 0.970076035674442 2086 Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|peptide catabolic process aspartic-type endopeptidase activity cell wall-bounded periplasmic space
YNL115C_p YNL115C hom 0.000647435627700236 0.970092223875549 2087 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene biological_process molecular_function integral to membrane|fungal-type vacuole
YLR116W MSL5 het FT RNA PROCESSING|NUCLEUS 0.000647295729372463 0.970098683342817 2088 Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA mRNA splicing, via spliceosome pre-mRNA branch point binding commitment complex
YHR079C-A SAE3 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.000646885123284108 0.970117642098178 2089 Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p double-strand break repair|reciprocal meiotic recombination|meiotic DNA recombinase assembly molecular_function condensed nuclear chromosome
YPL105C SYH1 hom FT PROTEIN LOCALIZATION|MITOCHONDRION 0.000646599342452108 0.970130837355446 2090 Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication nuclear pore distribution molecular_function mitochondrion|ribosome|cytoplasmic mRNA processing body|extrinsic to membrane|cytoplasm
YMR090W_p YMR090W hom 0.000646211699386343 0.970148735874664 2091 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability biological_process molecular_function cytoplasm
YGL044C RNA15 het FT RNA PROCESSING|NUCLEUS 0.000646060624668329 0.97015571140334 2092 Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping mRNA cleavage|mRNA polyadenylation mRNA binding|protein heterodimerization activity mRNA cleavage factor complex
YER019W ISC1 hom FT LIPID METABOLISM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.00064577843010454 0.970173187134909 2093 Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance response to salt stress|ceramide biosynthetic process|sphingolipid catabolic process inositol phosphosphingolipid phospholipase activity mitochondrion|endoplasmic reticulum|integral to mitochondrial outer membrane
YHR191C CTF8 hom FT CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.000645773927481426 0.970182289010133 2094 Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion maintenance of DNA trinucleotide repeats|mitotic sister chromatid cohesion molecular_function Ctf18 RFC-like complex
YIL096C_p YIL096C hom FT NUCLEUS 0.000645458379530173 0.970183518714271 2095 Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis biological_process S-adenosylmethionine-dependent methyltransferase activity nucleolus|nucleus
YGL215W CLG1 hom FT CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS 0.000644029336273662 0.97025393572168 2096 Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2 positive regulation of macroautophagy cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YGL083W SCY1 hom FT PROTEIN PHOSPHORYLATION 0.000643891031017749 0.970255887666549 2097 Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase biological_process molecular_function clathrin-coated vesicle
YOR245C DGA1 hom FT LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000643727019829966 0.970263460545153 2098 Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles lipid storage|triglyceride biosynthetic process diacylglycerol O-acyltransferase activity integral to membrane|lipid particle
YML015C TAF11 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.000643558923893323 0.970275652810425 2099 TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly transcription factor TFIID complex
YOR351C MEK1 hom FT CELL CYCLE|PROTEIN PHOSPHORYLATION|NUCLEUS 0.000643505307717598 0.9702736976493 2100 Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids meiosis|meiotic recombination checkpoint|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity nucleus
YCR011C ADP1 hom FT NUCLEOTIDE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000643296250232851 0.970283350456338 2101 Putative ATP-dependent permease of the ABC transporter family of proteins transport|transmembrane transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|endoplasmic reticulum|cytoplasm
YDR379C-A YDR379C-A hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000643128043120204 0.970291117083125 2102 Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy mitochondrial respiratory chain complex II assembly molecular_function mitochondrion
YPR154W PIN3 hom FT CYTOSKELETON ORGANIZATION|NUCLEUS 0.000643038210767166 0.970295264913395 2103 Protein that induces appearance of [PIN+] prion when overproduced actin cytoskeleton organization molecular_function nucleus|cytoplasm
YGR116W SPT6 het FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RNA LOCALIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME 0.000642330490104368 0.97032794253578 2104 Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region poly(A)+ mRNA export from nucleus|regulation of transcription by chromatin organization|regulation of mRNA 3'-end processing|transcription antitermination|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|regulation of transcriptional start site selection at RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of transcription from RNA polymerase II promoter|nucleosome organization|chromatin maintenance|regulation of nucleosome density|nucleosome assembly|chromatin remodeling|regulation of histone H3-K36 methylation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to stress core RNA polymerase II binding transcription factor activity|nucleosome binding|histone binding|DNA binding transcription antitermination factor activity mitochondrion|nucleus|transcriptionally active chromatin
YER166W DNF1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION|GOLGI APPARATUS|PLASMA MEMBRANE 0.000641964951535785 0.97034482058632 2105 Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity phospholipid-translocating ATPase activity|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism mitochondrion|integral to membrane|plasma membrane
YHR139C SPS100 hom FT KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS 0.00064137423739282 0.970372095720255 2106 Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin ascospore wall assembly molecular_function ascospore wall
YLR078C BOS1 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.000641338251844623 0.970373757287562 2107 v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|ER to Golgi transport vesicle membrane|endoplasmic reticulum membrane
YGL177W_d YGL177W hom 0.000641253107342602 0.970377688680761 2108 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR119W ASI1 hom FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.000641135984512392 0.970462651899695 2109 Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity integral to membrane|nuclear inner membrane|endoplasmic reticulum membrane
YHR075C PPE1 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.000640957228066641 0.970391350376133 2110 Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein cellular protein modification process|mitochondrial translation structural constituent of ribosome|carboxylesterase activity mitochondrial small ribosomal subunit
YLR435W TSR2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000640918133706066 0.970393155488828 2111 Protein with a potential role in pre-rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleus|cytoplasm
YPL072W UBP16 hom FT PROTEOLYSIS|MITOCHONDRION 0.000640528446784054 0.970411148598922 2112 Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria protein deubiquitination ubiquitin-specific protease activity mitochondrial outer membrane|cytoplasm
YER034W YER034W hom FT NUCLEUS 0.000640505093655839 0.970412226889133 2113 Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YBR098W MMS4 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS 0.000640087496416804 0.970431508726836 2114 Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p DNA repair|DNA topological change|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus transcription coactivator activity|endonuclease activity|crossover junction endodeoxyribonuclease activity Holliday junction resolvase complex|nucleus
YJR124C_p YJR124C hom 0.000640026695065858 0.970434316126583 2115 Putative protein of unknown function; expression induced under calcium shortage biological_process molecular_function integral to membrane
YBR093C PHO5 hom FT RESPONSE TO NUTRIENT LEVELS 0.000639949523289365 0.970437879403622 2116 Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 cellular response to phosphate starvation|phosphate-containing compound metabolic process|regulation of cell size nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|acid phosphatase activity fungal-type cell wall|cell wall-bounded periplasmic space
YFR006W_p YFR006W hom 0.000639526776376684 0.970457399042064 2117 Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene biological_process molecular_function cytoplasm
YBR072C-A_p YBR072C-A hom 0.000639199978402057 0.970472488409348 2118 Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YIL031W ULP2 het FT CELL CYCLE|PROTEOLYSIS|NUCLEUS 0.000638396029700775 0.970509609483724 2119 Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate plasmid maintenance|protein desumoylation|chromosome condensation|mitotic cell cycle spindle assembly checkpoint cysteine-type peptidase activity|SUMO-specific protease activity nucleus
YOR061W CKA2 hom FF|FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS 0.000638146269345123 0.970521141790673 2120 Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching regulation of transcription from RNA polymerase I promoter|chronological cell aging|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein serine/threonine kinase activity protein kinase CK2 complex|UTP-C complex
YHR187W IKI1 hom FT RNA PROCESSING|NUCLEUS 0.000637840195025433 0.970535274318203 2121 Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin tRNA modification tRNA binding|ATPase activity Elongator holoenzyme complex|nucleus|cytoplasm
YNL205C_d YNL205C hom 0.000637811407900169 0.970558566396549 2122 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL213C NOP6 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000637779638507735 0.970538070426644 2123 rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes ribosomal small subunit biogenesis RNA binding|rRNA binding nucleolus|90S preribosome
YNL118C DCP2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS 0.000637585365875084 0.970547040683136 2124 Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|deadenylation-independent decapping of nuclear-transcribed mRNA|stress granule assembly hydrolase activity|mRNA binding|m7G(5')pppN diphosphatase activity nucleus|cytoplasmic mRNA processing body|cytoplasm
YGR204C-A_p YGR204C-A hom 0.000637539496039144 0.970549158656695 2125 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YIL168W YIL168W hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.000637467856235059 0.970561244978526 2126 Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase serine family amino acid metabolic process L-serine ammonia-lyase activity cellular_component
YPL100W ATG21 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.000637220024284488 0.970563909810248 2127 Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein piecemeal microautophagy of nucleus|vesicle organization|mitochondrion degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway|protein lipidation phosphatidylinositol binding endosome|cytosol|fungal-type vacuole membrane
YNL043C_d YNL043C hom 0.000637196422728507 0.970564999578901 2128 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W Unknown Unknown Unknown
YJR006W POL31 het FT RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.000636994980342241 0.970574300900009 2129 Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair mismatch repair|RNA-dependent DNA replication|lagging strand elongation|base-excision repair|postreplication repair|DNA replication, removal of RNA primer|leading strand elongation|nucleotide-excision repair single-stranded DNA specific 3'-5' exodeoxyribonuclease activity|DNA-directed DNA polymerase activity delta DNA polymerase complex
YDL085C-A_p YDL085C-A hom FT NUCLEUS 0.000636986890483746 0.97057467443802 2130 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus biological_process molecular_function nucleus|cytoplasm
YDR045C RPC11 het FT NUCLEUS 0.000636784201105629 0.970584033341436 2131 RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS termination of RNA polymerase III transcription|tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YLR413W_p YLR413W hom FT PLASMA MEMBRANE 0.000636764821321558 0.970606855061672 2132 Putative protein of unknown function; YLR413W is not an essential gene biological_process molecular_function integral to membrane
YGL179C TOS3 hom FT CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION 0.000636656788859156 0.970589916428847 2133 Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome protein phosphorylation|glucose metabolic process protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YKL159C RCN1 hom FT SIGNALING 0.000636281567604077 0.970607241769912 2134 Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region calcium-mediated signaling protein phosphatase 2B binding|calcium-dependent protein serine/threonine phosphatase regulator activity cytoplasm
YGL203C KEX1 hom FT PROTEOLYSIS|GOLGI APPARATUS 0.000635814228572742 0.970628820545837 2135 Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins protein processing serine-type carboxypeptidase activity trans-Golgi network
YMR261C TPS3 hom FT CARBOHYDRATE METABOLISM 0.000635612208033358 0.970638148589868 2136 Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication trehalose biosynthetic process|response to stress enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YJL159W HSP150 hom FT CELL WALL ORG/BIOGENESIS 0.000635610638790643 0.97063822104769 2137 O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication fungal-type cell wall organization structural constituent of cell wall|ATPase activity fungal-type cell wall|extracellular region
YOR278W HEM4 het FT COFACTOR METABOLISM 0.000635366039296219 0.970649515126767 2138 Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria heme biosynthetic process uroporphyrinogen-III synthase activity cellular_component
YOL098C_p YOL098C hom FT PROTEOLYSIS 0.000635192171078386 0.970657543280222 2139 Putative metalloprotease biological_process molecular_function cytoplasm
YKR040C_d YKR040C hom 0.000635097697648606 0.970661905477165 2140 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W Unknown Unknown Unknown
YDR178W SDH4 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.000634154086983712 0.970718575918366 2141 Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II|mitochondrion
YPL196W OXR1 hom FT RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION 0.000633854252204359 0.970719320156073 2142 Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes cellular response to oxidative stress molecular_function mitochondrion
YBR254C TRS20 het FT VESICLE-MEDIATED TRANSPORT|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.000633420577076293 0.970739344647477 2143 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder ER to Golgi vesicle-mediated transport molecular_function TRAPP complex
YBR216C YBP1 hom FT RESPONSE TO OXIDATIVE STRESS 0.000632949561311281 0.970765451158815 2144 Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication cellular response to oxidative stress molecular_function cytoplasm
YPR144C NOC4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME