Strain Gene Zyg FClass FTerms similarity score p-value rank description GOBP GOMF GOCC
YDR052C DBF4 het FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION 1 0 1 Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress negative regulation of exit from mitosis|DNA replication initiation|positive regulation of protein kinase activity DNA replication origin binding|protein serine/threonine kinase activator activity Dbf4-dependent protein kinase complex
YBR134W_d YBR134W hom 0.195922537377949 2.16987310442541e-30 2 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL106C INP52 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.192439830353446 2.5649458813444e-29 3 Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity mating projection tip|cytoplasm|actin cortical patch
YOL003C PFA4 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.191420739697483 4.6329931101339e-29 4 Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases protein palmitoylation palmitoyltransferase activity integral to membrane|endoplasmic reticulum
YLL032C YLL032C hom 0.171302814607779 1.71947490910704e-23 5 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene biological_process molecular_function ribosome|cytoplasm
YLR102C APC9 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.159353655380942 1.57982346295953e-20 6 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition chromatin assembly|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YBL085W BOI1 hom FT SIGNALING|CELL DIVISION|SITE OF POLARIZED GROWTH 0.158594365817419 2.40447608074993e-20 7 Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction phospholipid binding site of polarized growth|cellular bud|mating projection tip|cellular bud neck
YPL210C SRP72 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.155952554798099 1.02025305297881e-19 8 Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER signal sequence binding signal recognition particle, endoplasmic reticulum targeting
YBR023C CHS3 hom FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH 0.148460238889958 5.3714786604793e-18 9 Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan ascospore wall assembly|fungal-type cell wall chitin biosynthetic process|cytokinesis chitin synthase activity incipient cellular bud site|integral to membrane|chitosome|prospore membrane|cellular bud neck|mating projection tip|cytoplasm
YDR121W DPB4 hom FT GENE SILENCING|NUCLEUS|CHROMOSOME 0.143886706230331 5.65206853881714e-17 10 Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization DNA-dependent DNA replication|chromatin silencing at telomere double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity chromatin accessibility complex|epsilon DNA polymerase complex
YBR020W GAL1 hom FT CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS 0.134814247472966 4.40464941871419e-15 11 Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication galactose catabolic process via UDP-galactose|carbohydrate phosphorylation|positive regulation of transcription by galactose galactokinase activity cytoplasm
YJR142W_p YJR142W hom 0.132966119503259 1.03929069005913e-14 12 Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member biological_process molecular_function cellular_component
YML103C NUP188 hom FT PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.130869696765633 2.71264409618614e-14 13 Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188 nuclear pore organization|protein import into nucleus|mRNA export from nucleus in response to heat stress structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore inner ring
YGL033W HOP2 hom FF|FT CELL CYCLE|NUCLEUS|CHROMOSOME 0.129571853536198 4.8753505285325e-14 14 Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair synapsis|reciprocal meiotic recombination protein binding|double-stranded DNA binding condensed nuclear chromosome
YNL273W TOF1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.129068944726018 6.32158859234814e-14 15 Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase DNA repair|DNA replication checkpoint|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|DNA replication|mitotic sister chromatid cohesion molecular_function nuclear chromosome|replication fork protection complex|nuclear replication fork
YDR435C PPM1 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS 0.127977689082427 1.01910768366019e-13 16 Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits cellular protein complex assembly|C-terminal protein methylation protein C-terminal leucine carboxyl O-methyltransferase activity cellular_component
YBR290W BSD2 hom FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM 0.126154014505274 2.22010830760292e-13 17 Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification metal ion transport|ubiquitin-dependent protein catabolic process|protein targeting to vacuole protein binding fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YKL196C YKT6 het FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|MITOCHONDRION|GOLGI APPARATUS|PLASMA MEMBRANE 0.124368939305003 4.82216961955236e-13 18 Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus intra-Golgi vesicle-mediated transport|vacuole fusion, non-autophagic|vesicle fusion palmitoyltransferase activity|SNAP receptor activity SNARE complex|endosome|mitochondrion|Golgi apparatus|fungal-type vacuole|membrane
YMR036C MIH1 hom FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS 0.122348150111237 1.14504562611057e-12 19 Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25 G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity protein tyrosine phosphatase activity nucleus|cytoplasm
YMR048W CSM3 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.120530216000171 2.46305801199062e-12 20 Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress DNA repair|DNA replication checkpoint|meiotic chromosome segregation|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|mitotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion molecular_function replication fork protection complex|nucleus
YOR091W TMA46 hom FT TRANSLATION 0.118312962974184 6.17317351524365e-12 21 Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p cytoplasmic translation molecular_function polysomal ribosome|ribosome|cytoplasm
YKL076C_d PSY1 hom 0.117568241018619 8.37314105491549e-12 22 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C Unknown Unknown Unknown
YDR483W KRE2 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.116865277085864 1.12236843513037e-11 23 Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YCL005W LDB16 hom FT MITOCHONDRION 0.116618482153717 1.2317310911015e-11 24 Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria biological_process molecular_function mitochondrion|lipid particle
YOL089C HAL9 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION 0.114508425167689 2.87160604684497e-11 25 Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication response to salt stress|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding mitochondrion|nucleus
YML119W_p YML119W hom 0.113674841666262 3.9950840544534e-11 26 Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate biological_process molecular_function cellular_component
YBL088C TEL1 hom FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|MITOCHONDRION|CHROMOSOME 0.11145116924797 9.77516145443915e-11 27 Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585) double-strand break repair|histone phosphorylation|telomere maintenance|response to DNA damage stimulus|phosphorylation|DNA damage induced protein phosphorylation protein kinase activity|telomeric DNA binding mitochondrion|nucleus
YBR082C UBC4 hom FT PROTEOLYSIS 0.110585959943066 1.33020297305372e-10 28 Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress ubiquitin binding|ubiquitin-protein ligase activity proteasome complex
YNR003C RPC34 het FT NUCLEUS|MITOCHONDRION 0.10987581307801 1.74590248442525e-10 29 RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity mitochondrion|DNA-directed RNA polymerase III complex|nucleus|cytoplasm
YMR121C RPL15B hom FT TRANSLATION|RIBOSOME 0.1094461147605 2.05645591975459e-10 30 Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YJL099W CHS6 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|GOLGI APPARATUS 0.109041803619438 2.44200609134891e-10 31 Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process molecular_function trans-Golgi network transport vesicle|clathrin-coated vesicle|exomer complex
YNL105W_d RRT16 hom 0.108776259364304 2.65101209246128e-10 32 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription Unknown Unknown Unknown
YGL178W MPT5 hom FT TRANSLATION 0.107941074831474 3.674604907008e-10 33 mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity negative regulation of translation|negative regulation of translational initiation|Unknown mRNA binding|protein binding, bridging cytoplasm
YMR294W JNM1 hom FF|FT CELL CYCLE|CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.107161410925544 4.85929961275553e-10 34 Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B nuclear migration|establishment of mitotic spindle orientation structural constituent of cytoskeleton dynactin complex|cell cortex|spindle pole body|astral microtubule
YOR051C ETT1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEUS 0.106536056480214 6.12985844139451e-10 35 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough translational termination molecular_function nucleus
YNL074C MLF3 hom 0.105279907894472 9.73509292097237e-10 36 Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide response to drug molecular_function cytoplasm
YAR003W SWD1 hom FT CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.103222517124306 2.05282716113354e-09 37 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 histone H3-K4 methylation|telomere maintenance|regulation of transcription, DNA-dependent|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YLR206W ENT2 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.103192638281069 2.0749712292651e-09 38 Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus actin filament organization|endocytosis|actin cortical patch assembly clathrin binding mating projection tip|actin cortical patch
YOR195W SLK19 hom FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.100972188133619 4.56699982975820e-09 39 Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate meiosis|mitotic spindle organization in nucleus molecular_function spindle midzone|condensed nuclear chromosome kinetochore|kinetochore|spindle
YOL013C HRD1 hom FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX 0.0998244868540367 6.82165348929909e-09 40 Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon fungal-type cell wall organization|ER-associated protein catabolic process ubiquitin-protein ligase activity Hrd1p ubiquitin ligase ERAD-M complex|integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YDR260C SWM1 hom FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0994623785920329 7.73516079628006e-09 41 Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation ascospore wall assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of mitotic metaphase/anaphase transition|protein ubiquitination molecular_function anaphase-promoting complex|nucleus
YHL044W_p YHL044W hom FT PLASMA MEMBRANE 0.0991432366452494 8.63801151185504e-09 42 Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern biological_process molecular_function plasma membrane
YMR214W SCJ1 hom FT PROTEIN LOCALIZATION|PROTEOLYSIS|ENDOPLASMIC RETICULUM 0.0990354460837166 8.9654771861896e-09 43 One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins ER-associated protein catabolic process|protein folding in endoplasmic reticulum|response to unfolded protein chaperone binding endoplasmic reticulum lumen
YLR330W CHS5 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH 0.0977548402523998 1.39077979547185e-08 44 Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane ascospore wall assembly|conjugation with cellular fusion|cell wall chitin catabolic process|Golgi to plasma membrane transport|cellular bud site selection|regulation of transcription, DNA-dependent molecular_function mating projection tip|cytoplasm|exomer complex
YNL027W CRZ1 hom FT TRANSCRIPTION FROM RNA POL II|SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|NUCLEUS 0.0970900239698199 1.74303584132119e-08 45 Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to calcium ion|positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cell wall chitin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter by pheromones|ion homeostasis|Unknown|positive regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YDR348C PAL1 hom FT SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0962359344984458 2.32445933617897e-08 46 Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cell cortex|cellular bud neck|mating projection tip
YDR217C RAD9 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.095831071067551 2.66202039780365e-08 47 DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of cell cycle|intra-S DNA damage checkpoint|nucleotide-excision repair|DNA damage checkpoint|positive regulation of transcription from RNA polymerase II promoter double-stranded DNA binding|histone binding chromatin|nucleus
YDR172W SUP35 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEOTIDE METABOLISM 0.095291210527287 3.18687608525468e-08 48 Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype translational termination|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay translation release factor activity cytosol|translation release factor complex
YJR091C JSN1 hom FT PROTEIN LOCALIZATION|MITOCHONDRION 0.0946742972026049 3.96462831649293e-08 49 Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|cellular protein complex localization|establishment of mitochondrion localization mRNA binding external side of mitochondrial outer membrane
YOR049C RSB1 hom FT MEMBRANE ORGANIZATION|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.0941881912362515 4.58908502909019e-08 50 Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane phospholipid translocation|fatty acid transport phospholipid-translocating ATPase activity integral to membrane|endoplasmic reticulum|plasma membrane
YDL203C ACK1 hom FT SIGNALING|CELL WALL ORG/BIOGENESIS|MITOCHONDRION 0.0922008143912321 8.76170170662675e-08 51 Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria fungal-type cell wall organization|positive regulation of signal transduction molecular_function mitochondrion
YOR256C TRE2 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT 0.091936105735749 9.54036422926199e-08 52 Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway molecular_function cellular_component
YMR124W_p YMR124W hom 0.0919287457943669 9.68953335433365e-08 53 Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization biological_process molecular_function cytoplasm
YPR027C_p YPR027C hom 0.0913711771825594 1.14324253059872e-07 54 Putative protein of unknown function biological_process molecular_function cellular_component
YML052W SUR7 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|MITOCHONDRION|PLASMA MEMBRANE 0.0907907806321062 1.37524834173169e-07 55 Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants endocytosis|ascospore formation molecular_function cell cortex|eisosome|mitochondrion|membrane raft|integral to membrane|plasma membrane|actin cortical patch
YPL232W SSO1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PLASMA MEMBRANE 0.0895070876078207 2.06122091194499e-07 56 Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p ascospore formation|ascospore-type prospore assembly|vesicle fusion phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|SNAP receptor activity SNARE complex|fungal-type vacuole membrane|plasma membrane|prospore membrane
YPR119W CLB2 hom FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0892023122523365 2.26724897266663e-07 57 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity nucleus|spindle pole body|cellular bud neck|spindle|cytoplasm
YIL106W MOB1 het FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON 0.0889736361309112 2.43475247682391e-07 58 Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress regulation of exit from mitosis|protein phosphorylation kinase regulator activity spindle pole body|cellular bud neck
YJL159W HSP150 hom FT CELL WALL ORG/BIOGENESIS 0.0883960944774984 2.91272324492838e-07 59 O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication fungal-type cell wall organization structural constituent of cell wall|ATPase activity fungal-type cell wall|extracellular region
YHR001W-A QCR10 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0883749287254404 2.93185781010512e-07 60 Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|mitochondrial respiratory chain complex III
YKL028W TFA1 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION|RNA POL II, HOLOENZYME 0.0876746069507131 3.63804586786899e-07 61 TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening transcriptional open complex formation at RNA polymerase II promoter|transcription from RNA polymerase II promoter single-stranded DNA binding|TFIIH-class transcription factor binding|RNA polymerase II core binding mitochondrion|transcription factor TFIIE complex
YML117W NAB6 hom 0.0873349434172449 4.15081047005458e-07 62 Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP biological_process molecular_function cytoplasm
YPR066W UBA3 hom 0.086896193732809 4.61544278323397e-07 63 Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern protein neddylation NEDD8 activating enzyme activity cytoplasm
YKL053W_d YKL053W hom 0.0864358188710571 5.32858486329198e-07 64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1 Unknown Unknown Unknown
YBL006C LDB7 hom FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|NUCLEUS|RSC COMPLEX 0.085947389590389 6.17544806851778e-07 65 Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions ATP-dependent chromatin remodeling|cell wall mannoprotein biosynthetic process|nucleosome disassembly|transcription elongation from RNA polymerase II promoter DNA translocase activity RSC complex
YDR149C_d YDR149C hom 0.0855755267209743 6.87940234590888e-07 66 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth Unknown Unknown Unknown
YEL007W MIT1 hom FT NUCLEUS 0.0851156714949085 7.89435457076066e-07 67 Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1 biological_process molecular_function nucleus|cytoplasm
YMR109W MYO5 hom FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0847616423909382 8.77245616601062e-07 68 One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization bipolar cellular bud site selection|endocytosis|exocytosis|fungal-type cell wall organization|response to salt stress|receptor-mediated endocytosis|actin cortical patch localization|response to osmotic stress microfilament motor activity mating projection tip|actin cortical patch
YBR248C HIS7 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM 0.0841328649983133 1.07260356233356e-06 69 Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor purine nucleoside monophosphate biosynthetic process|histidine biosynthetic process imidazoleglycerol-phosphate synthase activity intracellular
YLR331C_d JIP3 hom 0.0837475003884963 1.18828877846985e-06 70 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 Unknown Unknown Unknown
YKL035W UGP1 het FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.0836261017955744 1.22693482502267e-06 71 UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication (1->6)-beta-D-glucan biosynthetic process|UDP-glucose metabolic process|trehalose biosynthetic process|glycogen biosynthetic process UTP:glucose-1-phosphate uridylyltransferase activity plasma membrane|cytoplasm
YCR033W SNT1 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|NUCLEUS|CHROMOSOME 0.0834152725414002 1.32426308962107e-06 72 Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation|positive regulation of stress-activated MAPK cascade molecular_function Rpd3L-Expanded complex|Set3 complex
YLR135W SLX4 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0831759110495442 1.39981908145001e-06 73 Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress double-strand break repair via single-strand annealing, removal of nonhomologous ends|DNA replication|response to DNA damage stimulus|DNA-dependent DNA replication 5'-flap endonuclease activity Slx1-Slx4 complex|nucleus
YPR143W RRP15 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0830534812768537 1.45074421634436e-06 74 Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus|nucleus|preribosome, large subunit precursor
YBR098W MMS4 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS 0.0827847869388156 1.5688250011634e-06 75 Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p DNA repair|DNA topological change|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus transcription coactivator activity|endonuclease activity|crossover junction endodeoxyribonuclease activity Holliday junction resolvase complex|nucleus
YCR088W ABP1 hom FT PROTEIN LOCALIZATION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0825156860233776 1.69631177338906e-06 76 Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences protein localization|actin cortical patch assembly actin filament binding cell cortex|mating projection tip|cytoplasm|actin cortical patch
YJL073W JEM1 hom FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0821074887986054 1.91560567631567e-06 77 DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 karyogamy involved in conjugation with cellular fusion|ER-associated protein catabolic process|protein folding in endoplasmic reticulum unfolded protein binding|chaperone binding endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YDR513W GRX2 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION 0.0816959611721868 2.14894388450886e-06 78 Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication cellular response to oxidative stress disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity cytosol|mitochondrion
YPL194W DDC1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0810518768490688 2.6016046480533e-06 79 DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress meiosis|mitotic cell cycle G1/S transition checkpoint|intra-S DNA damage checkpoint|recombinational repair|G2/M transition checkpoint|cell cycle checkpoint molecular_function condensed nuclear chromosome|checkpoint clamp complex
YOR127W RGA1 hom FT SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0806929506615678 2.8615491630684e-06 80 GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth Rho GTPase activator activity cellular bud neck split septin rings
YPR029C APL4 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0802239583648836 3.26785748822262e-06 81 Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YIL046W MET30 het FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0800526078819677 3.44118257101102e-06 82 F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus response to cadmium ion|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA-dependent DNA replication initiation|M phase of mitotic cell cycle|response to arsenic-containing substance|G1/S transition of mitotic cell cycle|protein polyubiquitination|regulation of transcription involved in G1 phase of mitotic cell cycle|protein ubiquitination ubiquitin binding nuclear SCF ubiquitin ligase complex|SCF ubiquitin ligase complex|nucleus
YPL115C BEM3 hom FT SIGNALING|SITE OF POLARIZED GROWTH 0.0796782843773596 3.81027799991428e-06 83 Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly negative regulation of Rho protein signal transduction|establishment of cell polarity Rho GTPase activator activity|phosphatidylinositol-3-phosphate binding cell cortex|incipient cellular bud site|mating projection tip|cytoplasm|cellular bud tip
YOR284W HUA2 hom 0.0795972195957496 3.89787805272131e-06 84 Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly biological_process molecular_function cytoplasm
YGL060W YBP2 hom FT CELL CYCLE|NUCLEUS|CHROMOSOME|KINETOCHORE 0.0782175895956189 5.7199342165198e-06 85 Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication G2/M transition of mitotic cell cycle molecular_function condensed nuclear chromosome kinetochore|centromere-specific nucleosome|cytoplasm
YBR099C_d YBR099C hom 0.0777363801514123 6.5290200862472e-06 86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4 Unknown Unknown Unknown
YDR199W_d YDR199W hom 0.0770759134424584 7.84375370760178e-06 87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity Unknown Unknown Unknown
YPL124W SPC29 het FT CELL CYCLE|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON 0.0761197241763344 1.01265214356001e-05 88 Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication microtubule nucleation|spindle pole body duplication associated with nuclear envelope structural constituent of cytoskeleton central plaque of spindle pole body
YDR335W MSN5 hom FT PROTEIN LOCALIZATION|RNA LOCALIZATION|NUCLEUS 0.0748448209762005 1.42283117973025e-05 89 Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm tRNA re-export from nucleus|protein export from nucleus protein binding|importin-alpha export receptor activity integral to membrane|nucleus|cytoplasm
YDL043C PRP11 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS 0.0747154368208596 1.47235619092314e-05 90 Subunit of the SF3a splicing factor complex, required for spliceosome assembly spliceosomal complex assembly RNA binding U2 snRNP|U2-type prespliceosome
YNR040W_p YNR040W hom FT MITOCHONDRION 0.0746496505852495 1.50256003958239e-05 91 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YMR049C ERB1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0742339923013794 1.67146354824196e-05 92 Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 ribosomal large subunit biogenesis|rRNA processing molecular_function PeBoW complex|nucleolus|nucleus|preribosome, large subunit precursor
YJR017C ESS1 het FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING|NUCLEUS 0.0740981418336155 1.73213029426987e-05 93 Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3 termination of RNA polymerase II transcription|positive regulation of protein dephosphorylation|negative regulation of histone deacetylation|negative regulation of transcription from RNA polymerase II promoter|protein peptidyl-prolyl isomerization|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle peptidyl-prolyl cis-trans isomerase activity|RNA polymerase II core binding nucleus
YMR300C ADE4 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM 0.0739119235249327 1.85035203674342e-05 94 Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway 'de novo' IMP biosynthetic process amidophosphoribosyltransferase activity cytoplasm
YNL022C_p YNL022C hom FT NUCLEUS 0.0738293483342617 1.85840028264401e-05 95 Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis biological_process tRNA (cytosine-5-)-methyltransferase activity nucleus
YML101C-A_d YML101C-A hom 0.0736668060003466 1.93895925918356e-05 96 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL003W ULA1 hom 0.0735887083750191 1.97883797539871e-05 97 Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation protein neddylation NEDD8 activating enzyme activity cellular_component
YOL135C MED7 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0734856627164089 2.03265162431094e-05 98 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter molecular_function core mediator complex
YDL008W APC11 het FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0732456438918668 2.16344870238863e-05 99 Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YOR257W CDC31 het FF|FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON|NUCLEAR PORE 0.0730505584312535 2.27562027130601e-05 100 Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation microtubule nucleation|proteasomal ubiquitin-dependent protein catabolic process|spindle pole body duplication associated with nuclear envelope structural constituent of cytoskeleton integral to membrane|transcription export complex 2|nucleotide-excision repair factor 2 complex|half bridge of spindle pole body|nuclear pore
YLR037C PAU23 hom FT CELL WALL ORG/BIOGENESIS 0.072974325202965 2.35372718651524e-05 101 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth biological_process molecular_function fungal-type cell wall
YDL109C_p YDL109C hom FT LIPID METABOLISM 0.0729296749009414 2.34787990420129e-05 102 Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication cellular lipid metabolic process molecular_function cellular_component
YDR318W MCM21 hom FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE 0.0716481504714018 3.26082186537302e-05 103 Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function COMA complex|condensed nuclear chromosome kinetochore
YKL213C DOA1 hom FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS 0.0716016210104612 3.41773347150382e-05 104 WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process ubiquitin binding nucleus|cytoplasm
YDL101C DUN1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0715093558642767 3.37782592249884e-05 105 Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair protein phosphorylation|replication fork protection|cell cycle checkpoint|DNA damage checkpoint protein kinase activity nucleus
YMR239C RNT1 het FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|NUCLEUS 0.0714571788073029 3.42283351093379e-05 106 Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes U5 snRNA 3'-end processing|mRNA cleavage|chromatin organization|termination of RNA polymerase II transcription, exosome-dependent|U4 snRNA 3'-end processing|U1 snRNA 3'-end processing|rRNA transcription|rRNA processing ribonuclease III activity nucleoplasm|nucleolus
YKR035C_d OPI8 hom 0.0712874510501383 3.62146460023806e-05 107 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A Unknown Unknown Unknown
YLR387C REH1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RIBOSOME 0.0711581233016728 3.72171072098126e-05 108 Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains ribosomal large subunit biogenesis|budding cell bud growth molecular_function cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YIR003W AIM21 hom FT SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0709462923382128 3.89464903797323e-05 109 Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton mitochondrion migration along actin filament molecular_function ribosome|mating projection tip|actin cytoskeleton
YPL269W KAR9 hom FT NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0707909764226711 4.08219687382594e-05 110 Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase nuclear migration along microtubule|establishment of spindle localization molecular_function cell cortex|spindle pole body|mating projection tip
YNL256W FOL1 het FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|MITOCHONDRION 0.0704950936073913 4.36206205796433e-05 111 Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities tetrahydrofolate biosynthetic process dihydroneopterin aldolase activity|2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity|dihydropteroate synthase activity mitochondrial envelope|mitochondrion|cytoplasm
YHR192W LNP1 hom 0.0704236739498677 4.44075687352419e-05 112 Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS endoplasmic reticulum tubular network organization molecular_function endoplasmic reticulum tubular network|cytoplasm
YOL054W PSH1 hom FT PROTEOLYSIS|NUCLEUS|CHROMOSOME 0.0697637170514916 5.23444356318141e-05 113 E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity chromosome, centromeric region|nucleus
YIL125W KGD1 hom FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.0695870014073064 5.46875499224883e-05 114 Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA tricarboxylic acid cycle|2-oxoglutarate metabolic process oxoglutarate dehydrogenase (succinyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial matrix|mitochondrial oxoglutarate dehydrogenase complex
YMR223W UBP8 hom FT CHROMATIN ORGANIZATION|PROTEOLYSIS|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.0694771664535064 5.61935647894262e-05 115 Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B histone H3-K4 methylation|histone deubiquitination|histone H3-K79 methylation ubiquitin-specific protease activity|protein complex scaffold DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YDL066W IDP1 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.0693020485763291 5.86762013108152e-05 116 Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes isocitrate metabolic process|glutamate biosynthetic process isocitrate dehydrogenase (NADP+) activity mitochondrial nucleoid|mitochondrion
YNR005C_d YNR005C hom 0.0688420918049246 6.57008067098051e-05 117 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER072W VTC1 hom FT MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM 0.0686874778862812 6.82356881320578e-05 118 Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic mRNA binding integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex|intrinsic to vacuolar membrane
YGR211W ZPR1 het FT CELL CYCLE|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.0683895001025438 7.42991791025132e-05 119 Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress regulation of mitotic cell cycle|cellular response to starvation protein binding nucleus|cytoplasm
YPL066W RGL1 hom FF|FT SITE OF POLARIZED GROWTH 0.0681461748097709 7.78584475661785e-05 120 Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source protein localization to bud neck molecular_function cellular bud neck|cytoplasm
YDL179W PCL9 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH 0.0680631669086619 7.94429236010957e-05 121 Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p regulation of establishment or maintenance of cell polarity|regulation of transcription involved in G1/S phase of mitotic cell cycle cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|cellular bud neck
YML102W CAC2 hom FT CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.0679942599396722 8.07813330942168e-05 122 Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription DNA replication-dependent nucleosome assembly histone binding chromosome, centromeric region|CAF-1 complex
YDR389W SAC7 hom FF|FT CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.0676612340022156 8.75556053360192e-05 123 GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate actin filament reorganization involved in cell cycle|small GTPase mediated signal transduction Rho GTPase activator activity intracellular
YKL130C SHE2 hom FT RNA LOCALIZATION|NUCLEUS|SITE OF POLARIZED GROWTH 0.0676608899903819 8.75628726551361e-05 124 RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud mating type switching|intracellular mRNA localization mRNA binding cellular bud tip|cytoplasm
YPR104C FHL1 het FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|NUCLEUS|CHROMOSOME 0.0673753415865716 9.47038114130705e-05 125 Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter RNA polymerase II transcription corepressor binding|RNA polymerase II transcription coactivator binding|sequence-specific DNA binding|DNA binding nuclear chromatin|nucleolus|nucleus|CURI complex
YIL124W AYR1 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.0672599488524422 9.66630967105639e-05 126 NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones phosphatidic acid biosynthetic process acylglycerone-phosphate reductase activity mitochondrial outer membrane|mitochondrion|integral to membrane|endoplasmic reticulum|lipid particle|cytoplasm
YNL147W LSM7 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0671490245924956 9.90306202125486e-05 127 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasm
YLL036C PRP19 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION 0.0668291957013932 0.000106900416970046 128 Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain generation of catalytic spliceosome for first transesterification step ubiquitin-protein ligase activity|first spliceosomal transesterification activity mitochondrion|nucleus|Prp19 complex|cytoplasm|U2-type catalytic step 1 spliceosome
YDL003W MCD1 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CHROMOSOME 0.0665942304238089 0.000113053963774637 129 Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase double-strand break repair|apoptotic process|response to DNA damage stimulus|mitotic chromosome condensation|establishment of mitotic sister chromatid cohesion chromatin binding condensed nuclear chromosome|mitochondrion|nucleus|nuclear mitotic cohesin complex
YLR321C SFH1 het FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|RSC COMPLEX 0.066476563732536 0.000116532934283211 130 Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog ATP-dependent chromatin remodeling|double-strand break repair|chromosome segregation|regulation of DNA replication involved in S phase|chromatin remodeling at centromere|nucleosome disassembly|G2/M transition of mitotic cell cycle|transcription elongation from RNA polymerase II promoter DNA translocase activity RSC complex
YKR029C SET3 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.0663762868136669 0.000119058948633134 131 Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation methylated histone residue binding Rpd3L-Expanded complex|Set3 complex
YPR061C JID1 hom FT MITOCHONDRION 0.0663410974509849 0.000120056264068104 132 Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae biological_process molecular_function mitochondrion
YDR076W RAD55 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS 0.066311340147039 0.000120905766268988 133 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p DNA recombinase assembly|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|protein heterodimerization activity nucleus|Rhp55-Rhp57 complex
YBR143C SUP45 het FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|CELL DIVISION 0.0661402936214499 0.000125899652466053 134 Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p translational termination|cytokinesis translation release factor activity, codon specific|translation release factor activity cytosol|translation release factor complex
YLL040C VPS13 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|MITOCHONDRION|GOLGI APPARATUS 0.0658871689349575 0.000133647685495235 135 Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole|ascospore-type prospore membrane assembly molecular_function endosome|mitochondrion|prospore membrane|extrinsic to membrane
YOR297C TIM18 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION 0.0657365245995122 0.000138469729047866 136 Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex cellular response to oxidative stress|protein import into mitochondrial inner membrane|apoptotic process|response to acid|response to osmotic stress|response to arsenic-containing substance protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YGR017W_p YGR017W hom FT OXIDATION-REDUCTION PROCESS|NUCLEUS 0.0655433571281127 0.00014622378083981 137 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm biological_process molecular_function nucleus|cytoplasm
YPR150W_d YPR150W hom 0.0653041236448556 0.000153584835150387 138 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C Unknown Unknown Unknown
YDR269C_d YDR269C hom 0.0651888774523157 0.000157415459261851 139 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER126C NSA2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.065174822272624 0.000157932379421992 140 Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleus|preribosome, large subunit precursor
YBL024W NCL1 hom FT RNA PROCESSING|NUCLEUS 0.0651563047210483 0.000158615854275498 141 S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120 tRNA methylation tRNA (cytosine-5-)-methyltransferase activity nucleus
YMR142C RPL13B hom FT TRANSLATION|RIBOSOME 0.0649436750664536 0.000166665926860817 142 Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPR133W-A TOM5 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0647575222503744 0.000175197861491302 143 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore mitochondrial outer membrane translocase complex assembly|protein targeting to mitochondrion protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YPL018W CTF19 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE 0.0647125405707134 0.00017585161216658 144 Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2 attachment of spindle microtubules to kinetochore|chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function COMA complex|condensed nuclear chromosome kinetochore|nucleus
YMR211W DML1 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0646720646373035 0.000177508370554969 145 Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family plasmid maintenance|mitochondrial genome maintenance molecular_function mitochondrion|cytoplasm
YLR438C-A LSM3 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0643994865663772 0.000189053419963552 146 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex
YLR371W ROM2 hom FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|SITE OF POLARIZED GROWTH 0.0643686919952931 0.000190401185117058 147 GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p regulation of fungal-type cell wall organization|positive regulation of endocytosis|establishment of cell polarity|small GTPase mediated signal transduction|negative regulation of cAMP-mediated signaling|activation of Rho GTPase activity phosphatidylinositol-4,5-bisphosphate binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity incipient cellular bud site|mating projection tip|cellular bud tip
YMR275C BUL1 hom FT MITOCHONDRION ORGANIZATION|PLASMA MEMBRANE|UBIQUITIN LIGASE COMPLEX 0.0641295965044417 0.000201176819616308 148 Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication mitochondrion inheritance|protein monoubiquitination|protein polyubiquitination ubiquitin-ubiquitin ligase activity ubiquitin ligase complex|plasma membrane
YGR090W UTP22 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0640797824309669 0.000204834222042774 149 Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing molecular_function small-subunit processome|nucleolus|nucleus|UTP-C complex|90S preribosome|CURI complex
YKL114C APN1 hom FF|FT RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION 0.0638858349083631 0.00021275045625052 150 Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine base-excision repair 3'-tyrosyl-DNA phosphodiesterase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity mitochondrion|nucleus
YMR106C YKU80 hom FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0638660155398217 0.000213718436109208 151 Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair chromatin assembly or disassembly|protein localization to chromosome|chromatin silencing|double-strand break repair via nonhomologous end joining|donor selection|telomere maintenance|double-strand break repair via homologous recombination damaged DNA binding|RNA binding|DNA binding|telomeric DNA binding nuclear chromatin|nuclear telomeric heterochromatin|Ku70:Ku80 complex
YPR165W RHO1 het FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|CYTOSKELETON ORGANIZATION|MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0627704097063648 0.000274139217513527 152 GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process|regulation of fungal-type cell wall organization|positive regulation of endocytosis|budding cell bud growth|small GTPase mediated signal transduction|regulation of protein localization|positive regulation of protein kinase C signaling cascade|actin cytoskeleton organization|regulation of vacuole fusion, non-autophagic|actin cytoskeleton reorganization|regulation of exocyst localization|regulation of cell size GTPase activity|signal transducer activity incipient cellular bud site|mitochondrion|Golgi apparatus|peroxisome|cellular bud neck|cellular bud tip|mitochondrial outer membrane|1,3-beta-D-glucan synthase complex|plasma membrane|mating projection tip
YER179W DMC1 hom FT CELL CYCLE|NUCLEUS|CHROMOSOME 0.0626999306617076 0.000278528483969449 153 Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p meiosis|reciprocal meiotic recombination|meiotic joint molecule formation double-stranded DNA binding|single-stranded DNA binding condensed nuclear chromosome|nucleus
YOL047C_p YOL047C hom 0.0625958075480475 0.000285133627756276 154 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function integral to membrane|cytoplasm
YDR176W NGG1 hom FF|FT CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.0625145750520689 0.000290388243331093 155 Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex histone acetylation|chromatin modification histone acetyltransferase activity|transcription cofactor activity SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YOR015W_d YOR015W hom 0.0623751524957418 0.000299618868821458 156 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR173C VPS4 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM 0.0623559397713487 0.000300912191497559 157 AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport ATPase activity|protein homodimerization activity|ATP binding endosome|endoplasmic reticulum|membrane|cytoplasm
YCL064C CHA1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION 0.0619986976107893 0.000325933109732901 158 Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine threonine catabolic process|L-serine catabolic process L-threonine ammonia-lyase activity|L-serine ammonia-lyase activity mitochondrial nucleoid|mitochondrion
YOR177C MPC54 hom FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|NUCLEUS|CYTOSKELETON 0.061936977247058 0.000330448351189026 159 Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate ascospore wall assembly|vesicle docking structural molecule activity spindle pole body
YMR294W-A_d YMR294W-A hom 0.0619240016619309 0.000331405011889488 160 Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents Unknown Unknown Unknown
YMR273C ZDS1 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CELL WALL ORG/BIOGENESIS|RNA LOCALIZATION|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|SITE OF POLARIZED GROWTH|NUCLEAR PORE 0.0615926306961719 0.000356732067584248 161 Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication mRNA export from nucleus|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|chromatin silencing|establishment of cell polarity|regulation of protein localization|cell aging protein phosphatase type 2A regulator activity incipient cellular bud site|nuclear pore|cellular bud neck|cellular bud tip|cytoplasm
YLR238W FAR10 hom FT CELL CYCLE|SIGNALING|ENDOPLASMIC RETICULUM 0.061541458862829 0.000360800800596645 162 Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate re-entry into mitotic cell cycle after pheromone arrest molecular_function endoplasmic reticulum
YBL061C SKT5 hom FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON 0.061525048471723 0.000362114768420396 163 Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication fungal-type cell wall chitin biosynthetic process|response to osmotic stress|cytokinesis enzyme activator activity incipient cellular bud site|cellular bud neck septin ring|cellular bud neck
YBL046W PSY4 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS 0.0613875881657831 0.000373298065807129 164 Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2 Unknown|protein dephosphorylation protein phosphatase regulator activity nucleus|cytoplasm
YLR185W RPL37A hom FT TRANSLATION|RIBOSOME 0.0613128655404476 0.000379511824731345 165 Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YHR036W BRL1 het FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0612393313323071 0.000385720986948486 166 Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export mRNA export from nucleus|protein export from nucleus|nuclear envelope organization molecular_function nuclear envelope|endoplasmic reticulum
YMR011W HXT2 hom FT PLASMA MEMBRANE 0.0611275334360786 0.00039534315926236 167 High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose glucose transport pentose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YIL111W COX5B hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0610070696716929 0.000405961821254103 168 Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity|nitrite reductase (NO-forming) activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YNL298W CLA4 hom FF|FT CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0608371542275459 0.000431554157236983 169 Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p negative regulation of gene expression|vacuole inheritance|protein phosphorylation|budding cell apical bud growth|Rho protein signal transduction|regulation of exit from mitosis|establishment of cell polarity|sterol import|response to pheromone|cytokinesis protein serine/threonine kinase activity|protein kinase activity nucleus|cellular bud|fungal-type vacuole
YLR298C YHC1 het FT RNA PROCESSING|NUCLEUS 0.060596558956427 0.000444181141356223 170 Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site mRNA splicing, via spliceosome mRNA binding commitment complex|U1 snRNP|U2-type prespliceosome
YBR022W POA1 hom FT RNA PROCESSING 0.0603599279041641 0.000467711077290828 171 Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing tRNA splicing, via endonucleolytic cleavage and ligation phosphatase activity cellular_component
YER169W RPH1 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS 0.0603131867555198 0.000472494256490946 172 JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|histone demethylation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific) nucleus
YJL126W NIT2 hom 0.0603064772525397 0.000473184594259087 173 Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member biological_process hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds cellular_component
YFL013W-A_d YFL013W-A hom 0.059934030947683 0.000528087324484864 174 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching Unknown Unknown Unknown
YML127W RSC9 het FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|NUCLEUS|RSC COMPLEX 0.0594956699408104 0.000563888729240383 175 Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway G2/M transition of mitotic cell cycle|ATP-dependent chromatin remodeling|nucleosome disassembly|rRNA transcription|regulation of transcription from RNA polymerase II promoter|chromatin remodeling|transcription elongation from RNA polymerase II promoter|response to stress chromatin binding|DNA translocase activity RSC complex
YER089C PTC2 hom FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0590073304096483 0.000626073305185565 176 Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication endoplasmic reticulum unfolded protein response|inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation|DNA damage checkpoint protein serine/threonine phosphatase activity nucleus|cytoplasm
YNR007C ATG3 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.0589443010280451 0.000634548639885526 177 E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly Atg8 ligase activity cytosol|cytoplasm
YNL160W YGP1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS 0.058797431078732 0.0006547133455617 178 Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p cell wall assembly molecular_function extracellular region
YDR345C HXT3 hom FT PLASMA MEMBRANE 0.0586298436219769 0.000678449370857906 179 Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication hexose transport|transmembrane transport mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YJL169W_d YJL169W hom 0.0583257068306564 0.000723579338412648 180 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2 Unknown Unknown Unknown
YNL283C WSC2 hom FF|FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0582905328524472 0.000728974820962441 181 Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response fungal-type cell wall organization|response to heat|Rho protein signal transduction transmembrane signaling receptor activity site of polarized growth|cellular bud|mating projection tip|cytoplasm
YHR207C SET5 hom FT CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.0581974159947355 0.000743439279507623 182 Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus histone lysine methylation S-adenosylmethionine-dependent methyltransferase activity nuclear chromatin|nucleus|cytoplasm
YFR055W_p IRC7 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.057954332425199 0.000782464192121554 183 Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner sulfur compound metabolic process|L-cysteine catabolic process to pyruvate cysteine-S-conjugate beta-lyase activity cellular_component
YER147C SCC4 het FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0579233698063277 0.000787569211101077 184 Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX double-strand break repair|establishment of protein localization to chromatin|rDNA condensation|mitotic chromosome condensation|mitotic sister chromatid cohesion molecular_function nuclear chromatin|SMC loading complex
YPL017C IRC15 hom FT PROTEIN LOCALIZATION|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|CYTOSKELETON 0.0578610941027242 0.000797930740630284 185 Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci microtubule nucleation|mitotic recombination|microtubule anchoring|meiotic sister chromatid segregation|attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|positive regulation of mitotic cell cycle microtubule binding|S-adenosylmethionine-dependent methyltransferase activity microtubule|cytoplasm
YGL027C CWH41 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0573964402385051 0.000879324949771286 186 Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress fungal-type cell wall biogenesis|protein N-linked glycosylation mannosyl-oligosaccharide glucosidase activity endoplasmic reticulum membrane
YPR120C CLB5 hom FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0573649669452611 0.000885107351049502 187 B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase spindle assembly|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation|premeiotic DNA replication|positive regulation of DNA replication cyclin-dependent protein kinase regulator activity nucleus
YLR181C VTA1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT 0.0567397817948954 0.00100752609032499 188 Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain late endosome to vacuole transport via multivesicular body sorting pathway|positive regulation of protein oligomerization|late endosome to vacuole transport ATPase activator activity endosome|endosome membrane|multivesicular body
YOR190W SPR1 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 0.0567397384103755 0.00100753510426321 189 Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance ascospore formation glucan exo-1,3-beta-glucosidase activity fungal-type cell wall|ascospore wall
YPR023C EAF3 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME|HISTONE ACETYLTRANSFERASE 0.0566766166995662 0.00102072912939502 190 Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition DNA repair|histone acetylation|regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|histone deacetylation histone acetyltransferase activity Rpd3S complex|histone acetyltransferase complex|Rpd3L complex|NuA4 histone acetyltransferase complex
YLR424W SPP382 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS|MITOCHONDRION 0.0566401632607097 0.00102842144379262 191 Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation spliceosomal complex disassembly|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step RNA binding|ATP-dependent RNA helicase activity mitochondrion|U2-type post-mRNA release spliceosomal complex|nucleus|spliceosomal complex|cytoplasm
YMR320W_d YMR320W hom 0.0564877060357262 0.00106117728929938 192 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBL031W SHE1 hom FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0562946711298193 0.00110593185881026 193 Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function mitotic spindle elongation molecular_function microtubule cytoskeleton|nuclear microtubule|cellular bud neck|astral microtubule|spindle
YEL061C CIN8 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.0559975821783468 0.00117313107124457 194 Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation mitotic anaphase B|microtubule depolymerization|spindle pole body separation|mitotic spindle organization in nucleus|mitotic sister chromatid segregation plus-end-directed microtubule motor activity|minus-end-directed microtubule motor activity spindle microtubule|kinesin complex|mitochondrion|condensed nuclear chromosome kinetochore|kinetochore microtubule|astral microtubule
YJL174W KRE9 het FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 0.0558732382355536 0.00120321892116364 195 Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects (1->6)-beta-D-glucan metabolic process|fungal-type cell wall organization molecular_function extracellular region
YBR088C POL30 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.055784828906857 0.0012250432604413 196 Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair lagging strand elongation|postreplication repair|base-excision repair|nucleotide-excision repair|mismatch repair|meiotic mismatch repair|leading strand elongation|chromatin silencing at telomere|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette DNA polymerase processivity factor activity PCNA complex|nucleus|replication fork
YDL059C RAD59 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.0553711244863259 0.00133877529338101 197 Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p DNA strand renaturation|telomere maintenance via recombination|double-strand break repair via break-induced replication|double-strand break repair via single-strand annealing protein binding nucleus
YMR131C RRB1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0552847900171408 0.00135551260643027 198 Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p ribosome biogenesis molecular_function nucleolus
YAL014C SYN8 hom FT PROTEIN LOCALIZATION 0.0552781677069441 0.00135732339838471 199 Endosomal SNARE related to mammalian syntaxin 8 transport SNAP receptor activity endosome
YLR212C TUB4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON 0.0547318477016825 0.00153448731559961 200 Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress microtubule nucleation|mitotic spindle organization in nucleus structural constituent of cytoskeleton outer plaque of spindle pole body|gamma-tubulin small complex, spindle pole body|inner plaque of spindle pole body
YNL215W IES2 hom FT NUCLEUS 0.0546518534383943 0.0015616792526989 201 Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YER080W AIM9 hom FT MITOCHONDRION 0.0544290648285899 0.00160887245219385 202 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YDR253C MET32 hom FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|NUCLEUS 0.0541754867334727 0.00170005285204213 203 Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication regulation of mitotic cell cycle|regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus|cytoplasm
YKL036C_d YKL036C het 0.0540504591657656 0.00173430695871892 204 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W Unknown Unknown Unknown
YKL116C PRR1 hom FT TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION 0.0539285457379152 0.0017765723314888 205 Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation protein kinase activity|receptor signaling protein serine/threonine kinase activity cytoplasm
YML063W RPS1B hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0538743349071485 0.00179566860672731 206 Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YIL129C TAO3 het FT CELL DIVISION|MITOCHONDRION|SITE OF POLARIZED GROWTH 0.0538409425116271 0.00180752506032175 207 Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p cell morphogenesis|cell budding|budding cell apical bud growth molecular_function incipient cellular bud site|mitochondrion|cellular bud|mating projection tip
YJL131C AIM23 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0538018031318602 0.00182151359002549 208 Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss positive regulation of mitochondrial translational initiation ribosome binding|translation initiation factor activity mitochondrion
YBR231C SWC5 hom FF|FT CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.0536352372754842 0.00188216378424954 209 Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress chromatin remodeling|histone exchange molecular_function Swr1 complex|nucleus
YDL194W SNF3 hom FT CELL CYCLE|SIGNALING|PLASMA MEMBRANE 0.0535046384312682 0.00193100838298113 210 Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication mannose transport|glucose transport|signal transduction|negative regulation of meiosis|detection of glucose|fructose transport glucose transmembrane transporter activity|receptor activity|glucose binding integral to membrane|plasma membrane
YGR106C VOA1 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.053399837475436 0.00198643239063537 211 Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval protein complex assembly molecular_function fungal-type vacuole membrane|endoplasmic reticulum membrane
YLR395C COX8 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0533260904905297 0.00199966956161216 212 Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YOL069W NUF2 het FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.053098491853719 0.00210983512072963 213 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering microtubule nucleation|chromosome segregation structural constituent of cytoskeleton spindle microtubule|Ndc80 complex|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region|spindle pole body
YMR110C HFD1 hom FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.0530629078466818 0.00210496767509475 214 Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder cellular aldehyde metabolic process 3-chloroallyl aldehyde dehydrogenase activity mitochondrial outer membrane|endosome|mitochondrion|lipid particle|integral to mitochondrial outer membrane
YDR307W_p PMT7 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.052828593141173 0.0022029678933809 215 Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation biological_process molecular_function integral to membrane|endoplasmic reticulum
YGR078C PAC10 hom FT PROTEIN COMPLEX ORG/BIOGENESIS 0.0523326294040251 0.0024720148260085 216 Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding tubulin complex assembly tubulin binding prefoldin complex|polysome|cytoplasm
YBL018C POP8 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0520969965013809 0.00255538262207281 217 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing ribonuclease MRP activity|ribonuclease P activity nucleolar ribonuclease P complex|ribonuclease MRP complex
YJL137C GLG2 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.051957008642007 0.00262853065836121 218 Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication glycogen biosynthetic process glycogenin glucosyltransferase activity cytoplasm
YDR207C UME6 hom FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|CHROMOSOME 0.0519113130758035 0.0026398210574418 219 Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p spore germination|positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter during meiosis|lipid particle organization|nitrogen catabolite repression of transcription from RNA polymerase II promoter|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|repressing transcription factor binding|transcription factor binding transcription factor activity Rpd3L-Expanded complex|Rpd3L complex
YJL081C ARP4 het FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME|HISTONE ACETYLTRANSFERASE 0.0517390121379344 0.00275607483050358 220 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes DNA repair|histone acetylation|kinetochore assembly|chromatin organization|regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|chromatin remodeling chromatin binding|histone acetyltransferase activity|ATP-dependent 3'-5' DNA helicase activity nuclear chromatin|Swr1 complex|nucleus|Ino80 complex|NuA4 histone acetyltransferase complex
YDR167W TAF10 het FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE 0.0515799933670653 0.00279931776257923 221 Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|protein complex scaffold SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YNL002C RLP7 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS 0.0515408943713408 0.00283252378488867 222 Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA binding nucleolus|preribosome, large subunit precursor
YNL293W MSB3 hom FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH 0.0512280793114607 0.00299652219709157 223 Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress actin filament organization|exocytosis Rab GTPase activator activity incipient cellular bud site|polarisome|cellular bud tip
YKL002W DID4 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT 0.051185221384391 0.00302955244820082 224 Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis protein retention in Golgi apparatus|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport molecular_function ESCRT III complex|cytoplasm
YAL011W SWC3 hom FF|FT CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME 0.0511009835600966 0.00306480109828783 225 Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae endoplasmic reticulum organization|chromatin remodeling|histone exchange molecular_function mitochondrion|Swr1 complex|nucleus
YPL047W SGF11 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.0510739235661235 0.00308046233125907 226 Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation histone deubiquitination|regulation of transcription from RNA polymerase II promoter enzyme activator activity DUBm complex|nucleus|SAGA complex
YLR292C SEC72 hom FT PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0509544176933912 0.00315050364986644 227 Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation protein transporter activity Sec62/Sec63 complex|endoplasmic reticulum membrane
YML116W-A_d YML116W-A hom 0.0508947568400481 0.00319054727585058 228 Putative protein of unknown function Unknown Unknown Unknown
YER129W SAK1 hom FT CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION 0.050861118540222 0.00321075051388438 229 Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome protein phosphorylation|glucose metabolic process|DNA-dependent DNA replication protein serine/threonine kinase activity|protein kinase activity cytoplasm
YBR260C RGD1 hom FT SIGNALING|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0507768320069848 0.00325726775654819 230 GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization response to acid|osmosensory signaling pathway Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding cellular bud|mating projection tip|actin cortical patch
YDR001C NTH1 hom FT CARBOHYDRATE METABOLISM 0.050731732830792 0.00328490082322602 231 Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication trehalose catabolic process|response to stress alpha,alpha-trehalase activity cytosol|cytoplasm
YMR115W MGR3 hom FT PROTEOLYSIS|MITOCHONDRION 0.0507229924774817 0.00329028082163659 232 Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA misfolded or incompletely synthesized protein catabolic process misfolded protein binding mitochondrion|mitochondrial inner membrane|i-AAA complex
YCL014W BUD3 hom FT CELL CYCLE|SIGNALING|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.050648426766948 0.00333650587932593 233 Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding cellular bud site selection|axial cellular bud site selection|cytokinesis molecular_function cellular bud neck contractile ring|cellular bud neck
YOR050C_d YOR050C hom 0.0506095291766529 0.00336085333259927 234 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable Unknown Unknown Unknown
YDL144C YDL144C hom FT OXIDATION-REDUCTION PROCESS|NUCLEUS 0.0503929849674257 0.00349937700000616 235 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YDL134C PPH21 hom FT CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION 0.0503140410290985 0.00357099972994617 236 Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication actin filament organization|budding cell bud growth|protein dephosphorylation|G1/S transition of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|regulation of translation protein serine/threonine phosphatase activity protein phosphatase type 2A complex
YGR269W_d YGR269W hom 0.0500451628702221 0.00373278083377592 237 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C Unknown Unknown Unknown
YEL042W GDA1 hom FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0499351600977667 0.00380948939597634 238 Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate protein glycosylation guanosine-diphosphatase activity|uridine-diphosphatase activity Golgi apparatus
YMR016C SOK2 hom FT NUCLEUS 0.0498320410484309 0.00388269500081629 239 Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication pseudohyphal growth sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YLR457C NBP1 het FT CELL CYCLE|CYTOSKELETON ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON 0.0496459548020748 0.00401803993351385 240 Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication establishment of spindle pole body localization to nuclear envelope|spindle pole body duplication associated with nuclear envelope lipid binding integral to nuclear inner membrane|central plaque of spindle pole body|spindle pole body
YDR386W MUS81 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS 0.0496383571159169 0.00402365579437674 241 Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus crossover junction endodeoxyribonuclease activity|endonuclease activity Holliday junction resolvase complex|nucleus
YBR124W_d YBR124W het 0.0496297438651582 0.00403003092728063 242 Putative protein of unknown function Unknown Unknown Unknown
YOL060C MAM3 hom FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS 0.0496189822524115 0.00403800905814706 243 Protein required for normal mitochondrial morphology, has similarity to hemolysins cellular manganese ion homeostasis|mitochondrion organization molecular_function fungal-type vacuole membrane|integral to membrane
YCL044C MGR1 hom FT PROTEOLYSIS|MITOCHONDRION 0.0496090097282872 0.00408958465992967 244 Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA misfolded or incompletely synthesized protein catabolic process misfolded protein binding mitochondrion|i-AAA complex
YOL077C BRX1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.049600319209196 0.00405187890473091 245 Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif ribosomal large subunit assembly 5S rRNA binding|rRNA primary transcript binding nucleolus|preribosome, large subunit precursor
YHR092C HXT4 hom FT PLASMA MEMBRANE 0.0495139664589383 0.00411661819444017 246 High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication hexose transport pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity integral to membrane|plasma membrane
YGR032W GSC2 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PLASMA MEMBRANE|CYTOSKELETON 0.0494415721921425 0.0041716141397499 247 Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p) ascospore wall assembly|(1->3)-beta-D-glucan biosynthetic process 1,3-beta-D-glucan synthase activity 1,3-beta-D-glucan synthase complex|integral to membrane|actin cap|prospore membrane
YOR258W HNT3 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.0493605558950744 0.0042339493735238 248 DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress response to DNA damage stimulus DNA 5'-adenosine monophosphate hydrolase activity nucleus|cytoplasm
YDR244W PEX5 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION 0.0493553295247981 0.00423799947448244 249 Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions protein import into peroxisome matrix, docking peroxisome matrix targeting signal-1 binding|protein binding, bridging cytosol|peroxisomal membrane|peroxisome
YNL009W IDP3 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.0493532822371875 0.00425672148681873 250 Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication NADPH regeneration|fatty acid beta-oxidation|isocitrate metabolic process isocitrate dehydrogenase (NADP+) activity mitochondrion|peroxisome|cytoplasm
YFR028C CDC14 het FT CELL CYCLE|NUCLEUS|CYTOSKELETON 0.0493115545333718 0.00434144198682601 251 Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis regulation of exit from mitosis|mitotic cell cycle|protein dephosphorylation phosphoprotein phosphatase activity nucleolus|RENT complex|nucleus|spindle pole body
YDR180W SCC2 het FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0488776658634667 0.00462944107200318 252 Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin double-strand break repair|establishment of protein localization to chromatin|protein localization to chromatin|2-micrometer plasmid partitioning|mitotic chromosome condensation|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|establishment of mitotic sister chromatid cohesion|rDNA condensation|tRNA gene clustering molecular_function nuclear chromatin|2-micrometer circle DNA|SMC loading complex
YMR295C YMR295C hom FT SITE OF POLARIZED GROWTH 0.0484332059296228 0.00501658309818255 253 Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function ribosome|cellular bud|mating projection tip
YNL053W MSG5 hom FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0482396839993758 0.00518741906971513 254 Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|regulation of fungal-type cell wall organization|inactivation of MAPK activity involved in cell wall biogenesis|regulation of MAPK export from nucleus|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion protein tyrosine/serine/threonine phosphatase activity nucleus|cytoplasm
YAL008W FUN14 hom FT MITOCHONDRION 0.0482387345752175 0.00518830294119514 255 Mitochondrial protein of unknown function biological_process molecular_function mitochondrial outer membrane|mitochondrion
YPL112C PEX25 hom FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION 0.0482125241331356 0.00521275746472311 256 Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p protein import into peroxisome matrix|peroxisome organization molecular_function peroxisomal membrane
YMR242C RPL20A hom FF|FT TRANSLATION|RIBOSOME 0.0481557582734131 0.00527284931117264 257 Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YLR384C IKI3 hom FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS 0.0480262106973864 0.00538961039070232 258 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification molecular_function Elongator holoenzyme complex|nucleus|cytoplasm
YDR014W RAD61 hom FT CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0480090271931301 0.00540619106043104 259 Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin mitotic sister chromatid cohesion molecular_function nuclear cohesin complex
YHR103W SBE22 hom FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS|GOLGI APPARATUS 0.0479919290154381 0.00542273507445701 260 Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth fungal-type cell wall organization molecular_function cytoplasm
YIL057C RGI2 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.0479727866404447 0.00544131122774994 261 Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose energy reserve metabolic process molecular_function cytoplasm
YDR286C_p YDR286C hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.0479293145799281 0.00548371084822605 262 Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site biological_process molecular_function cellular_component
YLR023C IZH3 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0478983267969728 0.00554225553293618 263 Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity cellular zinc ion homeostasis metal ion binding integral to membrane|endoplasmic reticulum|membrane
YLL039C UBI4 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.0477863554035479 0.00562525334886567 264 Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress protein deubiquitination|ascospore formation|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress ATP-dependent protein binding|protein tag cytoplasm
YJL020C BBC1 hom FT CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.0477265322349955 0.00571427821696032 265 Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches actin cytoskeleton organization myosin I binding actin cortical patch
YNL299W TRF5 hom FT CELL CYCLE|RNA PROCESSING|CELL DIVISION|NUCLEUS 0.047723096228175 0.00568893054053229 266 Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation polynucleotide adenylyltransferase activity nucleolus|TRAMP complex
YGL149W_d YGL149W hom 0.0474670563495153 0.00595335284753476 267 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C. Unknown Unknown Unknown
YLR329W REC102 hom FT CELL CYCLE|NUCLEUS|CHROMOSOME 0.0474419698713821 0.00603242009347038 268 Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination meiotic DNA double-strand break formation|reciprocal meiotic recombination molecular_function condensed nuclear chromosome|nucleus
YOR034C-A_p YOR034C-A hom 0.0474296892664297 0.00600034989697648 269 Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YDR049W VMS1 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.0474243848664675 0.00599848209946299 270 Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans ER-associated protein catabolic process|mitochondria-associated protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process molecular_function cytosol|mitochondrion|endoplasmic reticulum membrane|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytoplasm
YJL047C RTT101 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0473662483248891 0.00606802337089366 271 Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p replication fork processing|negative regulation of transposition, RNA-mediated|regulation of mitosis|nonfunctional rRNA decay|ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity Cul8-RING ubiquitin ligase complex|nucleus|cytoplasm
YOR233W KIN4 hom FT CELL CYCLE|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0473356926415225 0.00613132826345534 272 Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication mitotic cell cycle spindle orientation checkpoint|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity cell cortex|spindle pole body|cellular bud neck
YIL107C PFK26 hom FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.047043869058827 0.00641474174025897 273 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A regulation of glycolysis|fructose 2,6-bisphosphate metabolic process 6-phosphofructo-2-kinase activity cytoplasm
YJL074C SMC3 het FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0469984982866488 0.00646606960790944 274 Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member synaptonemal complex assembly|ascospore formation|reciprocal meiotic recombination|mitotic sister chromatid cohesion|meiotic sister chromatid cohesion ATPase activity nucleus|nuclear mitotic cohesin complex
YIL014W MNT3 hom FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0469736624895945 0.00649432243286656 275 Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation protein O-linked glycosylation alpha-1,3-mannosyltransferase activity cellular_component
YNL314W DAL82 hom FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.0468212386220384 0.00667016154728265 276 Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain allantoin catabolic process|nitrogen catabolite activation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YBL077W_d YBL077W het 0.0467974887254515 0.00670611470212901 277 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C Unknown Unknown Unknown
YHR031C RRM3 hom FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|NUCLEUS|CHROMOSOME 0.0466401856481397 0.00694323966479928 278 DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p mitochondrial genome maintenance|replication fork progression beyond termination site|DNA replication ATP-dependent DNA helicase activity|DNA helicase activity nuclear telomeric heterochromatin|replication fork
YPL249C GYP5 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0466188704523284 0.00694377974130281 279 GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress vesicle-mediated transport|ER to Golgi vesicle-mediated transport Rab GTPase activator activity cytosol|incipient cellular bud site|plasma membrane|cellular bud neck|Golgi-associated vesicle|cellular bud tip
YGR107W_d YGR107W hom 0.0465904245121212 0.00694458442860173 280 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR099W YUH1 hom FT PROTEOLYSIS 0.0464856080853708 0.00707251828016869 281 Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p protein deubiquitination ubiquitin-specific protease activity cytoplasm
YGL074C_d YGL074C het 0.0464355206535531 0.00713439622164382 282 Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor Unknown Unknown Unknown
YML017W PSP2 hom 0.0463963909509376 0.00718307452651528 283 Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing biological_process molecular_function cytoplasm
YKL048C ELM1 hom FT CELL CYCLE|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0462076154621861 0.0074575879756335 284 Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring positive regulation of protein autophosphorylation|protein autophosphorylation|cell morphogenesis|budding cell bud growth|protein phosphorylation|response to drug|septin checkpoint|pseudohyphal growth|glucose metabolic process|axial cellular bud site selection|response to osmotic stress|cytokinesis protein serine/threonine kinase activity|protein kinase activity cellular bud neck contractile ring
YPR107C YTH1 het FF|FT RNA PROCESSING|NUCLEUS 0.0460469663088453 0.00767646652376046 285 Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation mRNA cleavage|mRNA polyadenylation RNA binding mRNA cleavage and polyadenylation specificity factor complex
YLR033W RSC58 het FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS|RSC COMPLEX 0.0460045343118276 0.00773280596791119 286 Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance nucleosome disassembly|transcription elongation from RNA polymerase II promoter|G1/S transition of mitotic cell cycle|chromatin remodeling molecular_function RSC complex
YKL125W RRN3 het FT NUCLEUS 0.0458903341928602 0.00784001765597213 287 Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript core RNA polymerase I binding transcription factor activity|RNA polymerase I transcription factor binding transcription factor activity|RNA polymerase I transcription factor binding|RNA polymerase I core binding nucleolus
YMR244C-A COA6 hom FT NUCLEUS|MITOCHONDRION 0.0458566832391381 0.0081207157850277 288 Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YIL101C XBP1 hom FT NUCLEUS 0.0458388575725467 0.0079097690027727 289 Transcriptional repressor; binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress response to stress sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YHR087W RTC3 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0458130681028925 0.00795424753849057 290 Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress RNA metabolic process molecular_function nucleus|cytoplasm
YDL146W LDB17 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0457272667073969 0.00806288664376782 291 Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck endocytosis molecular_function cellular bud|cellular bud neck|cytoplasm|actin cortical patch
YGR056W RSC1 hom FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|RSC COMPLEX 0.0457122113018594 0.00808374648044631 292 Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook double-strand break repair|ATP-dependent chromatin remodeling|regulation of sporulation resulting in formation of a cellular spore|double-strand break repair via nonhomologous end joining|nucleosome disassembly|transcription elongation from RNA polymerase II promoter DNA-dependent ATPase activity RSC complex
YJL005W CYR1 het FT SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE 0.0456546503821775 0.00816394529443011 293 Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation adenylate cyclase-modulating G-protein coupled receptor signaling pathway|Ras protein signal transduction adenylate cyclase activity mitochondrion|plasma membrane
YOR189W IES4 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0455687699560641 0.00828492479748472 294 Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses response to DNA damage stimulus molecular_function nucleus|Ino80 complex
YNL229C URE2 hom FF|FT PROTEIN LOCALIZATION 0.0455106570854769 0.00836769522249784 295 Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion regulation of nitrogen utilization|response to aluminum ion|protein urmylation|cytoplasmic sequestering of transcription factor glutathione peroxidase activity|phosphoprotein binding|transcription corepressor activity cytosol
YER071C_p TDA2 hom FT SITE OF POLARIZED GROWTH 0.0455072002770967 0.00846042778677909 296 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function mating projection tip|cytoplasm
YKR061W KTR2 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0453970466942011 0.00853164957231331 297 Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication cell wall mannoprotein biosynthetic process|protein N-linked glycosylation mannosyltransferase activity Golgi apparatus
YNL075W IMP4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0453321961600604 0.00862651894792996 298 Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs rRNA processing snoRNA binding|single-stranded telomeric DNA binding|rRNA primary transcript binding small-subunit processome|Mpp10 complex|90S preribosome
YOR141C ARP8 hom FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME|CYTOSKELETON 0.0452678601824733 0.00872156581927852 299 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity mitotic recombination|response to DNA damage stimulus|chromatin remodeling mRNA binding|ATP-dependent 3'-5' DNA helicase activity nucleus|Ino80 complex
YKL190W CNB1 hom FF|FT SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS 0.0452537523577424 0.00874253267352373 300 Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding calcineurin complex
YKL033W-A_p YKL033W-A hom 0.0451980272089127 0.00882579143065777 301 Putative protein of unknown function; similar to uncharacterized proteins from other fungi biological_process molecular_function cellular_component
YIL056W VHR1 hom FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.0451586619532074 0.00889519153437974 302 Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter in response to biotin starvation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus|cytoplasm
YIL084C SDS3 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0451468959684331 0.00894357636721333 303 Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|chromatin silencing|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation histone deacetylase activity Rpd3L-Expanded complex|Rpd3L complex
YHR063C PAN5 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM 0.0451446971049179 0.00890613408607335 304 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE pantothenate biosynthetic process 2-dehydropantoate 2-reductase activity cytoplasm
YHR141C RPL42B hom FT TRANSLATION|RIBOSOME 0.0450953311652303 0.00898108596958584 305 Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGL175C SAE2 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS 0.0449756669801075 0.00921724187009407 306 Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents DNA double-strand break processing|DNA catabolic process, endonucleolytic|meiotic DNA double-strand break formation|meiotic DNA double-strand break processing|gene conversion at mating-type locus, DNA double-strand break processing double-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity nucleus|cytoplasm
YOR155C ISN1 hom FT NUCLEOTIDE METABOLISM 0.0449479594368473 0.00920819972549138 307 Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms nicotinamide riboside biosynthetic process|inosine salvage|nicotinic acid riboside biosynthetic process IMP 5'-nucleotidase activity cellular_component
YLR332W MID2 hom FT RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PEROXISOME ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0445666667892756 0.00981975975241354 308 O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|cell morphogenesis involved in conjugation|response to acid|response to osmotic stress transmembrane signaling receptor activity integral to plasma membrane|mating projection tip
YMR152W YIM1 hom FT RESPONSE TO DNA DAMAGE|OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.0445454845708751 0.00985477120311373 309 Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress response to DNA damage stimulus molecular_function mitochondrion|lipid particle|cytoplasm
YJL138C TIF2 hom FT TRANSLATION|RIBOSOME 0.0442855222866512 0.0102935983769593 310 Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication translational initiation|regulation of translational initiation ATP-dependent RNA helicase activity|translation initiation factor activity ribosome|eukaryotic translation initiation factor 4F complex|plasma membrane|cytoplasm
YIR008C PRI1 het FT NUCLEUS|CHROMOSOME 0.0442101120360736 0.0104241058877554 311 Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair lagging strand elongation|DNA replication, synthesis of RNA primer|DNA replication initiation|DNA replication single-stranded DNA binding|DNA primase activity alpha DNA polymerase:primase complex|nuclear replication fork
YKL020C SPT23 hom FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0441144708563959 0.01062659740852 312 ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette DNA binding integral to endoplasmic reticulum membrane|nucleus
YML028W TSA1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|TRANSLATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS 0.0440893624366303 0.010636145438901 313 Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress protein folding|cellular response to oxidative stress|replicative cell aging|DNA protection|DNA damage checkpoint|cell redox homeostasis|response to hydroperoxide unfolded protein binding|ribosome binding|peroxiredoxin activity|thioredoxin peroxidase activity cytosol|polysome|cytoplasm
YFR017C IGD1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.0440780607935691 0.0107380731271943 314 Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication negative regulation of glycogen catabolic process enzyme inhibitor activity cytoplasm
YEL045C_d YEL045C hom 0.0439856719049203 0.010821279510407 315 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress Unknown Unknown Unknown
YGL073W HSF1 het FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION|NUCLEUS|MITOCHONDRION 0.0438730700912342 0.0110255620196035 316 Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated spindle pole body duplication|negative regulation of TOR signaling cascade|response to heat|regulation of transcription from RNA polymerase II promoter|response to stress sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity mitochondrion|nucleus
YFR015C GSY1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.043847099347122 0.0111212419223352 317 Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress glycogen biosynthetic process glycogen (starch) synthase activity mitochondrion|cytoplasm
YGL089C MF(ALPHA)2 hom FT SIGNALING 0.0437022842761506 0.0113419406982722 318 Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2 pheromone-dependent signal transduction involved in conjugation with cellular fusion mating pheromone activity extracellular region
YNL166C BNI5 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0435529881573214 0.0117753340104503 319 Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner septin ring assembly|cytokinesis molecular_function cellular bud neck septin ring|cellular bud neck
YHR013C ARD1 hom FT CHROMATIN ORGANIZATION|RIBOSOME 0.0435404274354297 0.0116491876170429 320 Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress histone acetylation|N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity cytosolic ribosome|NatA complex
YHR155W YSP1 hom FF|FT MITOCHONDRION 0.0434974259647743 0.0117320468654098 321 Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication biological_process molecular_function mitochondrion
YDR188W CCT6 het 0.043482307530791 0.0118747874917184 322 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif protein folding unfolded protein binding chaperonin-containing T-complex
YDL172C_d YDL172C hom 0.0434649229323124 0.0117950230743135 323 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YAR002W NUP60 hom FT PROTEIN LOCALIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0433004134785416 0.0121183872042752 324 FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153 double-strand break repair|poly(A)+ mRNA export from nucleus|protein export from nucleus|regulation of protein desumoylation|intracellular mRNA localization|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|chromosome organization|nucleocytoplasmic transport|chromatin silencing at silent mating-type cassette nucleocytoplasmic transporter activity|phospholipid binding|structural constituent of nuclear pore nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YOR276W CAF20 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION 0.0432030700592463 0.0123134046742662 325 Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E negative regulation of translation|positive regulation of cytoplasmic mRNA processing body assembly translation regulator activity mRNA cap binding complex
YBR091C TIM12 het FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0431670694536847 0.0123862290295101 326 Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins protein import into mitochondrial inner membrane phospholipid binding|protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YDL227C HO hom FT NUCLEUS 0.0431463980241893 0.0124282166451298 327 Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p mating type switching|gene conversion at mating-type locus, DNA double-strand break formation endonuclease activity nucleus
YCR014C POL4 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.0431052744771308 0.0125121212409042 328 DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta double-strand break repair|base-excision repair, gap-filling|double-strand break repair via nonhomologous end joining DNA-directed DNA polymerase activity nucleus
YER084W_p YER084W hom 0.0430693886584495 0.0125989527613318 329 Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YDL111C RRP42 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0430031575341425 0.0127226428820735 330 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7) nuclear polyadenylation-dependent tRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nonfunctional rRNA decay|nuclear polyadenylation-dependent mRNA catabolic process|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing molecular_function nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YDR418W RPL12B hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0427724648534091 0.0132098065976661 331 Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YMR190C SGS1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0427690043042616 0.0132172381994495 332 Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes; forms nuclear foci upon DNA replication stress DNA double-strand break processing|meiotic DNA double-strand break processing|telomeric 3' overhang formation|meiotic chromosome segregation|DNA unwinding involved in replication|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint|telomere maintenance via recombination|replicative cell aging|DNA duplex unwinding|response to DNA damage stimulus|negative regulation of meiotic joint molecule formation|chromosome organization|regulation of reciprocal meiotic recombination|gene conversion at mating-type locus, DNA double-strand break processing|mitotic sister chromatid segregation ATP-dependent DNA helicase activity RecQ helicase-Topo III complex|nucleolus
YJR054W KCH1 hom 0.0427360241340637 0.0132882494139295 333 Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate biological_process molecular_function integral to membrane|fungal-type vacuole
YCR006C_d YCR006C hom 0.0427314674744228 0.0132980870392908 334 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL094C KHA1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION|GOLGI APPARATUS 0.0427309350540712 0.0133958310828115 335 Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies monovalent inorganic cation transport potassium:hydrogen antiporter activity mitochondrion|integral to membrane|Golgi apparatus
YBR196C PGI1 het FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION 0.0427168432766551 0.0133710829485826 336 Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation gluconeogenesis|pentose-phosphate shunt|glycolysis glucose-6-phosphate isomerase activity cytosol|mitochondrion|plasma membrane
YOR094W ARF3 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH 0.0425403487820004 0.0137165420460892 337 Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity intracellular protein transport|positive regulation of phosphatidylinositol biosynthetic process|endocytosis|actin filament bundle assembly|actin cortical patch localization|cellular bud site selection mRNA binding|GTPase activity cellular bud neck|cellular bud tip
YLR306W UBC12 hom 0.0423922874447484 0.0141348349457386 338 Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes protein neddylation NEDD8 ligase activity cellular_component
YPR082C DIB1 het FT CELL CYCLE|RNA PROCESSING|CELL DIVISION|NUCLEUS 0.0423755941904275 0.0140865585974831 339 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein mRNA splicing, via spliceosome molecular_function U4/U6 x U5 tri-snRNP complex|U5 snRNP
YGL037C PNC1 hom FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING|NUCLEUS 0.0423475281670476 0.0141504613175933 340 Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress replicative cell aging|chromatin silencing at rDNA|nicotinate nucleotide salvage|chromatin silencing at telomere nicotinamidase activity nucleus|peroxisome|cytoplasm
YGL092W NUP145 het FT PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0421187427592008 0.0146809844600059 341 Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98 double-strand break repair|poly(A)+ mRNA export from nucleus|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|tRNA export from nucleus|protein targeting to nuclear inner membrane|telomere tethering at nuclear periphery|nuclear pore distribution|positive regulation of transcription, DNA-dependent|NLS-bearing substrate import into nucleus|protein import into nucleus nucleocytoplasmic transporter activity|RNA binding|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore|nuclear pore outer ring
YNR019W ARE2 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0420928499206033 0.0148015653177648 342 Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication ergosterol metabolic process ergosterol O-acyltransferase activity integral to membrane|endoplasmic reticulum
YMR264W CUE1 hom FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|UBIQUITIN LIGASE COMPLEX 0.0419739380113723 0.0150257537668268 343 Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication ER-associated protein catabolic process|establishment of protein localization to endoplasmic reticulum membrane ubiquitin-protein ligase activator activity Doa10p ubiquitin ligase complex|mitochondrion|integral to endoplasmic reticulum membrane
YKR031C SPO14 hom FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM|NUCLEUS 0.0418622034306997 0.0152966381528724 344 Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions phospholipid metabolic process|exocytosis|cell morphogenesis involved in conjugation with cellular fusion|ascospore-type prospore assembly phospholipase D activity|phosphatidylinositol-3-phosphate binding endosome|nucleus|prospore membrane
YNL098C RAS2 hom FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS|PLASMA MEMBRANE 0.0418139644375106 0.0154149086652214 345 GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes pseudohyphal growth|ascospore formation|activation of adenylate cyclase activity|regulation of protein localization|replicative cell aging|positive regulation of transcription by galactose|Ras protein signal transduction GTP binding|GTPase activity plasma membrane
YDR266C HEL2 hom 0.0418043503799817 0.0154385759574968 346 RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor biological_process molecular_function ribosome|cytoplasm
YDL016C_d YDL016C het 0.0417832018833091 0.0154907505534092 347 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication Unknown Unknown Unknown
YMR103C_d YMR103C hom 0.0417459629700329 0.0155829982523284 348 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL047W ALG13 het FT LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0415842666664596 0.0159891765840643 349 Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress dolichol-linked oligosaccharide biosynthetic process N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity cytosol|UDP-N-acetylglucosamine transferase complex|extrinsic to endoplasmic reticulum membrane|endoplasmic reticulum|nucleus|cytoplasm
YPR142C_d YPR142C het 0.0414384001797236 0.016363543192326 350 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing Unknown Unknown Unknown
YLR244C MAP1 hom FT PROTEOLYSIS|RIBOSOME 0.04131715330075 0.0169588208873086 351 Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p negative regulation of gene expression|protein initiator methionine removal involved in protein maturation metalloaminopeptidase activity|mRNA binding cytosolic ribosome
YOR188W MSB1 hom FT MITOCHONDRION|SITE OF POLARIZED GROWTH 0.0412793646911931 0.0167804589339455 352 Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress establishment of cell polarity molecular_function mitochondrion|cellular bud neck|cellular bud tip
YDR117C TMA64 hom FT TRANSLATION 0.0412645711259534 0.0168197104377691 353 Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity biological_process RNA binding ribosome
YLR208W SEC13 het FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|NUCLEAR PORE 0.0412538633417979 0.0168481714472541 354 Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress positive regulation of transcription, DNA-dependent|ER-associated protein catabolic process|positive regulation of GTPase activity|nuclear pore distribution|COPII-coated vesicle budding structural molecule activity COPII vesicle coat|nuclear pore outer ring|Seh1-associated complex
YOR223W YOR223W hom FT ENDOPLASMIC RETICULUM 0.0411226467522375 0.0172003882921774 355 Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3 biological_process molecular_function fungal-type vacuole lumen|endoplasmic reticulum
YPL038W MET31 hom FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.0411171591460397 0.0172152579629506 356 Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus|cytoplasm
YIR025W MND2 hom FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CHROMOSOME SEGREGATION|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0410639756200296 0.0173599533620838 357 Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|reciprocal meiotic recombination|regulation of mitotic metaphase/anaphase transition|protein ubiquitination|mitotic sister chromatid segregation molecular_function nucleus|anaphase-promoting complex
YML128C MSC1 hom FT CELL CYCLE|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.0409390672232696 0.0177039883156223 358 Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated reciprocal meiotic recombination molecular_function mitochondrion|endoplasmic reticulum|plasma membrane
YER125W RSP5 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGAN 0.0409007039025323 0.0178108443778688 359 E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; ubiquitylates Sec23p cellular response to UV|late endosome to vacuole transport via multivesicular body sorting pathway|chromatin assembly or disassembly|response to drug|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitin-dependent endocytosis|protein monoubiquitination|positive regulation of fatty acid biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of phosphate metabolic process|regulation of ubiquinone biosynthetic process|regulation of dolichol biosynthetic process|regulation of multivesicular body size|positive regulation of transcription from RNA polymerase II promoter|regulation of nitrogen utilization|proteasomal ubiquitin-dependent protein catabolic process|positive regulation of endocytosis|regulation of actin cytoskeleton organization|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|regulation of protein localization|mitochondrion organization|regulation of mRNA export from nucleus|regulation of ergosterol biosynthetic process|ribophagy|Unknown|protein polyubiquitination ubiquitin binding|ubiquitin-protein ligase activity|phosphatidylinositol binding mitochondrion|ubiquitin ligase complex|Golgi apparatus|cytoplasm|cellular bud tip|endosome membrane|extrinsic to internal side of plasma membrane|plasma membrane|nucleus
YNL087W TCB2 hom FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.0408926902581373 0.0178332365328236 360 ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud biological_process lipid binding cellular bud|cortical endoplasmic reticulum
YBR056W YBR056W hom FT CARBOHYDRATE METABOLISM 0.0408777516922439 0.0179605572977611 361 Putative glycoside hydrolase of the mitochondrial intermembrane space biological_process molecular_function cytoplasm
YFR053C HXK1 hom FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0408603220136668 0.0179239327221194 362 Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication mannose metabolic process|glucose import|glycolysis|fructose import|glucose metabolic process|fructose metabolic process hexokinase activity cytosol|mitochondrion|cytoplasm
YMR001C-A_p YMR001C-A hom 0.0407831192322096 0.0181418880796585 363 Putative protein of unknown function biological_process molecular_function cellular_component
YHL012W_p YHL012W hom 0.0406540781000033 0.0185113726781215 364 Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YNL233W BNI4 hom FT PROTEIN LOCALIZATION|CELL DIVISION|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0406210146859516 0.0186070963189652 365 Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p asymmetric protein localization|barrier septum assembly|chitin biosynthetic process protein binding incipient cellular bud site|cellular bud neck septin collar|cellular bud neck|septin ring
YAL029C MYO4 hom FT RNA LOCALIZATION|MITOCHONDRION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0405412325646633 0.0188398623542948 366 Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization microfilament motor activity|actin filament binding mitochondrion|filamentous actin|myosin V complex|cellular bud|cellular bud tip
YKL150W MCR1 hom FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION 0.0405390898587066 0.0188993890555274 367 Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis ergosterol biosynthetic process|cellular response to oxidative stress cytochrome-b5 reductase activity mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane|mitochondrial intermembrane space
YOR006C TSR3 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0403850859024511 0.0193027993017793 368 Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress maturation of SSU-rRNA molecular_function nucleus|cytoplasm
YOL015W IRC10 hom 0.0403316544175145 0.0195361526124793 369 Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YDR115W YDR115W hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0402911964874207 0.0195859165098064 370 Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrial large ribosomal subunit
YMR073C IRC21 hom FF 0.0402713612076114 0.0197927947484515 371 Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study response to drug molecular_function cytoplasm
YIL002W-A_p YIL002W-A hom 0.0402693009388194 0.0196524600471417 372 Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YLR054C OSW2 hom FT CELL WALL ORG/BIOGENESIS 0.0402307437631102 0.01978846642918 373 Protein of unknown function proposed to be involved in the assembly of the spore wall ascospore wall assembly molecular_function integral to membrane|prospore membrane|cytoplasm
YIR020C_p YIR020C hom 0.0402250920555696 0.019787418616676 374 Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YOR346W REV1 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION|CHROMOSOME 0.0401651713643561 0.0199716321870266 375 Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress error-prone translesion synthesis|error-free translesion synthesis deoxycytidyl transferase activity|DNA-directed DNA polymerase activity nuclear chromatin|mitochondrion|replication fork
YDL062W_d YDL062W hom 0.0400853791479687 0.0202192584578436 376 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential Unknown Unknown Unknown
YHR129C ARP1 hom FT CELL CYCLE|CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.0400372751995991 0.0203698339294201 377 Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin nuclear migration|establishment of mitotic spindle orientation structural constituent of cytoskeleton cell cortex|dynactin complex|spindle pole body|astral microtubule
YFL028C CAF16 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM|NUCLEUS 0.0400019725262703 0.0204809599004828 378 Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator regulation of transcription from RNA polymerase II promoter ATPase activity CCR4-NOT complex|cytoplasm
YNL094W APP1 hom FT CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.0399911849278544 0.0205150224218577 379 Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway actin cytoskeleton organization molecular_function actin cytoskeleton|actin cortical patch
YGR223C HSV2 hom FT MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS 0.0399587725351768 0.0206176638530585 380 Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization piecemeal microautophagy of nucleus phosphatidylinositol binding endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YOR372C NDD1 het FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS 0.0398957262471843 0.0209713581457705 381 Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes positive regulation of transcription involved in G2/M-phase of mitotic cell cycle transcription coactivator activity nucleus
YEL036C ANP1 hom FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.0397146659771642 0.0214051649558285 382 Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol protein N-linked glycosylation alpha-1,6-mannosyltransferase activity|mannosyltransferase activity alpha-1,6-mannosyltransferase complex|Golgi cis cisterna
YER016W BIM1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.0397094613171152 0.0214222366908086 383 Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally nuclear migration along microtubule|microtubule nucleation|microtubule depolymerization|negative regulation of microtubule depolymerization|positive regulation of microtubule polymerization|mitotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint microtubule plus-end binding|protein homodimerization activity|structural constituent of cytoskeleton spindle midzone|microtubule plus end|cytoplasmic microtubule|spindle pole body|kinetochore|spindle pole|spindle
YBL026W LSM2 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0396291304059981 0.0216872359583422 384 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|cytoplasmic mRNA processing body|U4/U6 x U5 tri-snRNP complex
YBR084C-A RPL19A hom FT TRANSLATION|RIBOSOME 0.0396273524847876 0.0220885072276115 385 Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YOR140W SFL1 hom FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING|NUCLEUS 0.0395267773318783 0.0220488183197497 386 Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p gene silencing|Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YMR278W PGM3 hom FT CARBOHYDRATE METABOLISM|NUCLEUS 0.0395043710434567 0.0221044519739088 387 Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential biological_process phosphoglucomutase activity nucleus|cytoplasm
YDL028C MPS1 het FT PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.0393983802973019 0.0224643677345048 388 Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p protein phosphorylation|sister chromatid biorientation|spindle assembly|spindle pole body duplication associated with nuclear envelope|mitotic cell cycle spindle assembly checkpoint protein serine/threonine/tyrosine kinase activity|protein kinase activity condensed nuclear chromosome kinetochore|spindle pole body
YJR018W_d YJR018W hom 0.0393859764645658 0.0225068187909706 389 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL012C HTZ1 hom FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0393142013594846 0.0227538340624691 390 Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin nuclear-transcribed mRNA catabolic process, non-stop decay|regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette chromatin binding nuclear chromatin|chromatin assembly complex
YGL218W_d YGL218W hom 0.0393057630636175 0.0228846194562471 391 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YER006W NUG1 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0393021290041814 0.0227956117792846 392 GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus ribosomal large subunit export from nucleus|rRNA processing RNA binding|GTPase activity nucleolus|nucleus|preribosome, large subunit precursor
YBR119W MUD1 hom FT RNA PROCESSING|NUCLEUS 0.0392305819797965 0.0230445780033672 393 U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing mRNA splicing, via spliceosome U1 snRNA binding|RNA binding U1 snRNP|U2-type prespliceosome
YML020W_p YML020W hom 0.0392087673151561 0.0231209558001736 394 Putative protein of unknown function biological_process molecular_function cellular_component
YLR020C YEH2 hom FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|PLASMA MEMBRANE 0.0391793770830476 0.0232242046504349 395 Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism cell wall mannoprotein biosynthetic process|sterol metabolic process sterol esterase activity integral to membrane|plasma membrane
YML048W GSF2 hom FF|FT PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.039158519180671 0.023297721684452 396 ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression protein folding|protein localization to cell surface unfolded protein binding mitochondrial outer membrane|integral to endoplasmic reticulum membrane|cytoplasm
YOR082C_d YOR082C hom 0.0391283067323132 0.0234045683994685 397 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W Unknown Unknown Unknown
YCR106W RDS1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0391134752243834 0.0234571756204774 398 Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide response to xenobiotic stimulus sequence-specific DNA binding|DNA binding nucleus
YJL155C FBP26 hom FT CARBOHYDRATE METABOLISM 0.0390515622114151 0.0237195783731451 399 Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress glucose metabolic process 6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity cytosol
YDR186C YDR186C hom 0.0389843768526869 0.0239194351349114 400 Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function ribosome|cytoplasm
YDR254W CHL4 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE 0.0389814400593142 0.0239300420643243 401 Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15 kinetochore assembly|chromosome segregation|establishment of meiotic sister chromatid cohesion|protein localization to chromosome, centromeric region|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion structural molecule activity condensed nuclear chromosome outer kinetochore
YFR037C RSC8 het FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|RSC COMPLEX 0.0389540077959081 0.0240293173105506 402 Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters ATP-dependent chromatin remodeling|double-strand break repair via nonhomologous end joining|nucleosome disassembly|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|G1/S transition of mitotic cell cycle DNA translocase activity|DNA binding RSC complex|nucleus
YKR044W UIP5 hom FT ENDOMEMBRANE SYSTEM|NUCLEUS 0.0388955701094693 0.0242419896226974 403 Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates biological_process molecular_function nuclear envelope
YIL035C CKA1 hom FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0388591838428582 0.0243752324831234 404 Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein serine/threonine kinase activity|protein kinase activity protein kinase CK2 complex|UTP-C complex
YBR036C CSG2 hom FF|FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0388444491877862 0.0244293695198644 405 Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress cellular calcium ion homeostasis|glycosphingolipid biosynthetic process enzyme regulator activity integral to endoplasmic reticulum membrane|integral to membrane
YOL109W ZEO1 hom FT CELL WALL ORG/BIOGENESIS|MITOCHONDRION|PLASMA MEMBRANE 0.0387300903080451 0.0248530912303496 406 Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria fungal-type cell wall organization|response to stress molecular_function mitochondrial outer membrane|mitochondrion|extrinsic to plasma membrane|plasma membrane
YLR439W MRPL4 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0386193121062128 0.0252695973471586 407 Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YDR177W UBC1 het FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS 0.0385737538064451 0.0254426328248872 408 Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress spore germination|vesicle organization|endocytosis|ER-associated protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination ubiquitin-protein ligase activity proteasome complex
YGL072C_d YGL072C hom FF 0.0385300585354629 0.0256095541325046 409 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 Unknown Unknown Unknown
YNR021W_p YNR021W hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0385106839326962 0.0257059153231442 410 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene biological_process molecular_function endoplasmic reticulum
YKR093W PTR2 hom FF|FT PROTEIN LOCALIZATION|PLASMA MEMBRANE 0.0384050366160228 0.0260923939018026 411 Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p dipeptide transport|tripeptide transport|peptide transport dipeptide transporter activity|tripeptide transporter activity|peptide transporter activity integral to membrane|plasma membrane
YML068W ITT1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION 0.0382834283339498 0.0265695763623902 412 Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins regulation of translational termination molecular_function cellular_component
YPL202C AFT2 hom FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|MITOCHONDRION 0.0382523422000048 0.0267153973993369 413 Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication cellular response to oxidative stress|cellular iron ion homeostasis|positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription mitochondrion|nucleus
YPL005W AEP3 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0382007964652823 0.0270120927732545 414 Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA mRNA metabolic process|mitochondrial translational initiation molecular_function mitochondrion|mitochondrial inner membrane|cytoplasm|extrinsic to membrane
YIL126W STH1 het FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|RSC COMPLEX 0.038137860694423 0.0271735698144767 415 ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p double-strand break repair|ATP-dependent chromatin remodeling|nucleosome positioning|chromosome segregation|chromatin remodeling at centromere|nucleosome disassembly|regulation of transcription, DNA-dependent|G2/M transition of mitotic cell cycle|meiosis|cytoskeleton organization|transcription elongation from RNA polymerase II promoter histone acetyl-lysine binding|DNA translocase activity|helicase activity|DNA-dependent ATPase activity RSC complex|nucleus
YIL017C VID28 hom FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS 0.0381305354799926 0.0271801939616734 416 GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process|ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function nucleus|GID complex|cytoplasm
YNL045W LAP2 hom FT KETONE METABOLISM|LIPID METABOLISM|PROTEOLYSIS|NUCLEUS 0.0381190021490423 0.0272267424753153 417 Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus cellular lipid metabolic process|protein catabolic process aminopeptidase activity|leukotriene-A4 hydrolase activity|epoxide hydrolase activity nucleus|cytoplasm
YPL089C RLM1 hom FT TRANSCRIPTION FROM RNA POL II|SIGNALING|NUCLEUS 0.0380889662355663 0.02734829024818 418 MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication signal transduction|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|DNA binding, bending|sequence-specific DNA binding nucleus
YMR001C CDC5 het FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0380166517559818 0.0278055950545569 419 Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate synaptonemal complex disassembly|spindle assembly involved in meiosis|protein phosphorylation|resolution of meiotic recombination intermediates|positive regulation of spindle pole body separation protein kinase activity nucleus|cellular bud neck|spindle pole
YBR001C NTH2 hom FF|FT CARBOHYDRATE METABOLISM|MITOCHONDRION 0.0379731844833704 0.0278212187148394 420 Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication trehalose catabolic process alpha,alpha-trehalase activity mitochondrion|cytoplasm
YNL321W VNX1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0379526974682842 0.0279056309196241 421 Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate potassium ion transport|sodium ion transport|hydrogen transport potassium:hydrogen antiporter activity|sodium:hydrogen antiporter activity|calcium:hydrogen antiporter activity fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum membrane|fungal-type vacuole
YBR108W AIM3 hom FT CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.037931348528346 0.0279938292280046 422 Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss actin cortical patch assembly molecular_function membrane raft|actin cortical patch
YDL207W GLE1 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|NUCLEAR PORE 0.037904178749547 0.0281064222714147 423 Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export poly(A)+ mRNA export from nucleus|mRNA export from nucleus|regulation of translational initiation|regulation of translational termination translation initiation factor binding|inositol hexakisphosphate binding|phospholipid binding|enzyme activator activity mitochondrion|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore|cytoplasm
YLR204W QRI5 hom FF|FT RNA PROCESSING|MITOCHONDRION 0.0378144099624694 0.0284812071828785 424 Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA mRNA processing molecular_function mitochondrion|integral to mitochondrial inner membrane
YDR132C YDR132C hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|NUCLEUS|PLASMA MEMBRANE 0.0377838767411353 0.0286096603998514 425 Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YHR179W OYE2 hom FT OXIDATION-REDUCTION PROCESS|NUCLEUS|MITOCHONDRION 0.0377606592974685 0.0287076696591156 426 Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress apoptotic process NADPH dehydrogenase activity mitochondrion|nucleus|cytoplasm
YKL111C_d YKL111C het 0.0377474931878501 0.0287633768925153 427 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1 Unknown Unknown Unknown
YFL008W SMC1 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0376898234334683 0.0293216282909506 428 Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure double-strand break repair|mitotic sister chromatid cohesion|mitotic sister chromatid segregation double-stranded DNA binding|ATPase activity|AT DNA binding|DNA secondary structure binding nuclear mitotic cohesin complex
YCR101C_p YCR101C hom 0.0375641374135957 0.0295731637586819 429 Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene biological_process molecular_function integral to membrane|membrane
YNR012W URK1 hom FT NUCLEOTIDE METABOLISM|NUCLEUS 0.0375266172886895 0.0297118920139931 430 Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP pyrimidine-containing compound salvage uridine kinase activity nucleus|cytoplasm
YER173W RAD24 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0375153148583123 0.0297611431684385 431 Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein reciprocal meiotic recombination|DNA damage checkpoint|nucleotide-excision repair DNA clamp loader activity Rad17 RFC-like complex|nucleus
YIL032C_d YIL032C hom 0.0374309540185284 0.0301801721438086 432 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL185W ASH1 hom FT CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.0372481491661163 0.0309459373807303 433 Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|core promoter proximal region sequence-specific DNA binding Rpd3L-Expanded complex|nucleus|cellular bud|Rpd3L complex
YGR206W MVB12 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT 0.0372219491630979 0.0310642757190721 434 ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin negative regulation of protein complex assembly|protein targeting to vacuole|endosome transport via multivesicular body sorting pathway ubiquitin binding cytosol|endosome|ESCRT I complex
YIL025C_d YIL025C hom 0.0371632221498154 0.0313309408720288 435 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL192C SOP4 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0371611850393647 0.0313402260184532 436 ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum
YHR079C-A SAE3 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0371390442296278 0.0314412960930501 437 Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p double-strand break repair|reciprocal meiotic recombination|meiotic DNA recombinase assembly molecular_function condensed nuclear chromosome
YPL075W GCR1 het FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM|NUCLEUS 0.0371257842749755 0.0315019598652906 438 Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p negative regulation of transcription from RNA polymerase II promoter by glucose|nucleosome organization|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from a mobile element promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nuclear envelope
YDR053W_d YDR053W het 0.0371227082877503 0.0315160467172551 439 Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex Unknown Unknown Unknown
YNR016C ACC1 het FF|FT PROTEIN LOCALIZATION|KETONE METABOLISM|LIPID METABOLISM|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.0371147319335556 0.0315526005492269 440 Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; nuclear envelope organization|protein import into nucleus|fatty acid biosynthetic process biotin carboxylase activity|acetyl-CoA carboxylase activity mitochondrion|endoplasmic reticulum membrane
YDR004W RAD57 hom FF|FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS 0.0371119649587708 0.0315652894590473 441 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p DNA recombinase assembly|telomere maintenance via recombination|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|protein heterodimerization activity nucleus|Rhp55-Rhp57 complex
YBL074C AAR2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS 0.0370672173781066 0.0317711030365674 442 Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron assembly of spliceosomal tri-snRNP molecular_function U5 snRNP
YJL019W MPS3 het FT CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON 0.0369495010879285 0.0323438086282374 443 Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p meiotic telomere clustering|synapsis|nuclear migration involved in conjugation with cellular fusion|spindle pole body duplication associated with nuclear envelope|telomere tethering at nuclear periphery|mitotic sister chromatid cohesion molecular_function nuclear envelope|nuclear periphery|integral to membrane|nuclear chromosome, telomeric region|half bridge of spindle pole body
YJL168C SET2 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.0368885910369404 0.032604181718405 444 Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p negative regulation of histone H3-K14 acetylation|DNA-dependent transcription, elongation|ascospore formation|regulation of transcription, DNA-dependent|histone deacetylation|regulation of DNA-dependent DNA replication initiation|histone methylation|negative regulation of antisense RNA transcription|Unknown|negative regulation of reciprocal meiotic recombination|positive regulation of histone acetylation histone methyltransferase activity|histone methyltransferase activity (H3-K36 specific) nucleus
YNR065C_p YNR065C hom 0.0368551275582895 0.0327623112452462 445 Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene biological_process molecular_function integral to membrane
YLR075W RPL10 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0367956990614932 0.0330447550290873 446 Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects cytoplasmic translation|translational termination|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YDL084W SUB2 het FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.036792698356758 0.033059071458524 447 Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|mRNA splicing, via spliceosome|transcription elongation from RNA polymerase II promoter|chromatin silencing at telomere ATP-dependent RNA helicase activity chromosome, telomeric region|nucleus|transcription export complex|spliceosomal complex
YHR029C YHI9 hom FT SIGNALING 0.036792224267623 0.0332449901325097 448 Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production endoplasmic reticulum unfolded protein response molecular_function cellular_component
YAL002W VPS8 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|GOLGI APPARATUS 0.0366897021809865 0.0336330533538094 449 Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole GTPase binding|protein anchor late endosome|membrane|CORVET complex
YGR145W ENP2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0366862415216338 0.033570424297656 450 Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p ribosomal small subunit biogenesis|rRNA processing molecular_function nucleolus|90S preribosome
YLR180W SAM1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM 0.0366811825663228 0.0335948917886047 451 S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication methionine metabolic process|S-adenosylmethionine biosynthetic process methionine adenosyltransferase activity cytoplasm
YIR036C_p IRC24 hom FT OXIDATION-REDUCTION PROCESS 0.0365294910827454 0.0343356581533421 452 Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci biological_process molecular_function integral to membrane|cytoplasm
YGR218W CRM1 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.0364760206325704 0.0346810715792357 453 Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin mRNA export from nucleus|protein export from nucleus|protein localization to kinetochore|ribosomal large subunit export from nucleus protein transporter activity integral to membrane|nucleus|spindle pole body|kinetochore
YGR057C LST7 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM 0.0364375301192001 0.0347914958669642 454 Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport protein transporter activity vesicle coat
YKL071W_p YKL071W hom FT OXIDATION-REDUCTION PROCESS 0.0364307321922158 0.0348253963412376 455 Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function integral to membrane|cytoplasm
YLR084C RAX2 hom FT CELL CYCLE|CELL DIVISION|MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0363900726775613 0.0350559461906539 456 N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p cellular bud site selection molecular_function mitochondrion|cellular bud scar|cellular bud neck|membrane
YML038C YMD8 hom FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0363323737523865 0.0353190624481185 457 Putative nucleotide sugar transporter, has similarity to Vrg4p UDP-glucose transport|nucleotide-sugar transport nucleotide-sugar transmembrane transporter activity COPI-coated vesicle|integral to membrane
YGR066C_p YGR066C hom 0.036230025533126 0.0358390785409879 458 Putative protein of unknown function biological_process molecular_function cellular_component
YNL080C EOS1 hom FT CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.036230009417173 0.0358391609349192 459 Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene cellular response to oxidative stress|protein N-linked glycosylation molecular_function integral to membrane|endoplasmic reticulum membrane
YPL234C VMA11 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS 0.0362249775913632 0.0358648943915937 460 Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane|fungal-type vacuole
YOR138C RUP1 hom FT NUCLEUS 0.0362057584373688 0.0359633288322446 461 Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress protein deubiquitination protein binding nucleus|cytoplasm
YBR224W_d YBR224W hom 0.0361926758260315 0.0360304654754843 462 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1 Unknown Unknown Unknown
YPR040W TIP41 hom FT SIGNALING|NUCLEUS 0.0361821504106147 0.0360845567444066 463 Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress signal transduction molecular_function nucleus|cytoplasm
YIL160C POT1 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS 0.0360766996967692 0.0366303096635794 464 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids fatty acid beta-oxidation mRNA binding|acetyl-CoA C-acyltransferase activity peroxisomal matrix|peroxisome
YDR069C DOA4 hom FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION 0.0360310018108844 0.0368689900287446 465 Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole protein deubiquitination|endocytosis|regulation of DNA replication|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|free ubiquitin chain depolymerization|ubiquitin homeostasis|ubiquitin-dependent protein catabolic process endopeptidase activity|ubiquitin-specific protease activity|ubiquitin thiolesterase activity endosome|proteasome complex|mitochondrion
YPL203W TPK2 hom FT SIGNALING|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0358869412715416 0.0376301029507178 466 cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase protein phosphorylation|Ras protein signal transduction|invasive growth in response to glucose limitation cAMP-dependent protein kinase activity|protein kinase activity nucleus|cAMP-dependent protein kinase complex
YGR284C ERV29 hom FT VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0358769898920919 0.0376831687989907 467 Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress ER to Golgi vesicle-mediated transport molecular_function integral to membrane|ER to Golgi transport vesicle
YKL168C KKQ8 hom FT PROTEIN PHOSPHORYLATION 0.0358746653450257 0.0378958351973275 468 Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication biological_process protein kinase activity cytoplasm
YGL159W_p YGL159W hom 0.0357917595436426 0.0382554500151177 469 Putative protein of unknown function; deletion mutant has no detectable phenotype biological_process molecular_function cellular_component
YCR094W CDC50 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|GOLGI APPARATUS 0.0357098880178576 0.0387289090851262 470 Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication intracellular protein transport|phospholipid translocation|endocytosis|actin cortical patch localization phospholipid-translocating ATPase activity trans-Golgi network|late endosome membrane
YIR015W RPR2 het FT RNA PROCESSING|NUCLEUS 0.0356955257679993 0.0386620460884921 471 Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress tRNA processing|intronic box C/D snoRNA processing ribonuclease P activity nucleolar ribonuclease P complex
YPR151C SUE1 hom FT PROTEOLYSIS|MITOCHONDRION 0.0356757057416163 0.0387702586221923 472 Mitochondrial protein required for degradation of unstable forms of cytochrome c protein catabolic process molecular_function mitochondrial envelope
YAL013W DEP1 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0356419888148324 0.038954935841527 473 Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|regulation of DNA-dependent DNA replication initiation|Unknown molecular_function Rpd3L-Expanded complex|Rpd3L complex
YIL001W_p YIL001W hom 0.0356260655404878 0.0390424114881935 474 Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm biological_process molecular_function cytoplasm
YML049C RSE1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|NUCLEUS 0.0355709485625533 0.0393758380919608 475 Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport spliceosomal complex assembly|mRNA splicing, via spliceosome U2 snRNA binding U2 snRNP|U2-type prespliceosome
YDL234C GYP7 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM 0.0353583952385912 0.0405380245306105 476 GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking regulation of vacuole fusion, non-autophagic|vesicle-mediated transport Rab GTPase activator activity cytoplasm
YHL007C STE20 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH 0.0353412094295673 0.040635687177843 477 Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p negative regulation of gene expression|osmosensory signaling pathway via Sho1 osmosensor|activation of MAPKKK activity|vacuole inheritance|protein phosphorylation|cellular bud site selection|cellular response to heat|regulation of exit from mitosis|pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|pseudohyphal growth|sterol import|stress granule assembly|invasive growth in response to glucose limitation|positive regulation of apoptotic process histone serine kinase activity|MAP kinase kinase kinase kinase activity|protein kinase activity incipient cellular bud site|plasma membrane|nucleus|mating projection tip
YER135C_d YER135C hom 0.0353398326560755 0.0406435196544288 478 Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Unknown Unknown Unknown
YNL154C YCK2 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0353260715820227 0.0407218768389033 479 Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication endocytosis|cell morphogenesis|protein phosphorylation|cytokinesis|response to glucose stimulus protein serine/threonine kinase activity|protein kinase activity plasma membrane|cellular bud neck|mating projection
YMR052W FAR3 hom FT CELL CYCLE|SIGNALING|ENDOPLASMIC RETICULUM 0.0353011326777175 0.0408642080687362 480 Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress re-entry into mitotic cell cycle after pheromone arrest molecular_function endoplasmic reticulum
YDL021W GPM2 hom FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.0353005650869583 0.0408674523189913 481 Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event biological_process phosphoglycerate mutase activity|molecular_function cytosol|cytoplasm
YEL018W EAF5 hom FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.0352555046791911 0.0412163767153628 482 Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex DNA repair molecular_function nucleus|NuA4 histone acetyltransferase complex
YDL050C_d YDL050C hom 0.0350945091335144 0.0420597378940661 483 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR027C_d YBR027C hom 0.0350545071088764 0.042294576723063 484 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR511W ACN9 hom FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|MITOCHONDRION 0.0350331693496625 0.0425745671046333 485 Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes carbon utilization|regulation of gluconeogenesis molecular_function mitochondrion|mitochondrial intermembrane space
YJL013C MAD3 hom FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS 0.0350087156890662 0.0425647633137596 486 Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover distributive segregation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint molecular_function mitotic checkpoint complex
YNL333W SNZ2 hom FT COFACTOR METABOLISM 0.0349975981582279 0.0426305805964492 487 Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p pyridoxine metabolic process|thiamine biosynthetic process protein binding cellular_component
YNR023W SNF12 hom FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|RSC COMPLEX 0.0349498136359185 0.0430698684502851 488 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex
YPL273W SAM4 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.0349245051762451 0.0430654462635634 489 S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio homocysteine metabolic process|L-methionine biosynthetic process from S-adenosylmethionine|S-adenosylhomocysteine metabolic process homocysteine S-methyltransferase activity nucleus|cytoplasm
YJL056C ZAP1 hom FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.0348899978679388 0.0433969916600289 490 Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II regulatory region sequence-specific DNA binding|zinc ion binding nucleus
YOL086W-A MHF1 hom FT RESPONSE TO DNA DAMAGE 0.034882454651476 0.0433173191677877 491 Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1 response to DNA damage stimulus molecular_function cellular_component
YHR107C CDC12 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.034764449790494 0.0443473504410273 492 Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells maintenance of cell polarity|cell cycle cytokinesis|positive regulation of protein kinase activity|septin ring assembly protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding septin filament array|cellular bud neck septin ring|septin complex|cytoplasm|mating projection
YER181C_d YER181C hom 0.0346394816448822 0.044797155958439 493 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies Unknown Unknown Unknown
YOR375C GDH1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS 0.0345807488847917 0.0451611985345203 494 NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication glutamate biosynthetic process|ammonia assimilation cycle glutamate dehydrogenase (NADP+) activity nucleus|cytoplasm
YOR231W MKK1 hom FT SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION|SITE OF POLARIZED GROWTH 0.0345768578265174 0.0452174748772905 495 MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication signal transduction|peroxisome degradation|protein phosphorylation protein kinase activity|MAP kinase kinase activity cellular bud tip
YLR350W ORM2 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.034573863532356 0.0452040387417259 496 Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein molecular_function integral to membrane|endoplasmic reticulum|SPOTS complex
YML006C GIS4 hom FT SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0345705295498474 0.0452247948624251 497 CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway cellular ion homeostasis|intracellular signal transduction molecular_function plasma membrane
YDR271C_d YDR271C hom 0.0345088533083175 0.0456102187136059 498 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W Unknown Unknown Unknown
YDL133W SRF1 hom 0.0345024193456448 0.0456505843748496 499 Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients positive regulation of catalytic activity molecular_function integral to membrane
YPL150W_p YPL150W hom FT PROTEIN PHOSPHORYLATION 0.0344526381350107 0.0459639219149903 500 Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study protein phosphorylation protein kinase activity cellular_component
YHR081W LRP1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION|NUCLEUS 0.0343380234185742 0.0469877727881425 501 Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination U5 snRNA 3'-end processing|nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear retention of pre-mRNA at the site of transcription|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) double-stranded RNA binding|double-stranded DNA binding nuclear exosome (RNase complex)
YNR018W RCF2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0342506213318163 0.0472541196331572 502 Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast mitochondrial respiratory chain complex IV assembly molecular_function mitochondrion|mitochondrial respiratory chain supercomplex|mitochondrial respiratory chain complex IV|integral to mitochondrial inner membrane
YJR043C POL32 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0341889136953149 0.0477538010501296 503 Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p RNA-dependent DNA replication|lagging strand elongation|postreplication repair|base-excision repair|DNA replication, removal of RNA primer|nucleotide-excision repair|mismatch repair|double-strand break repair via break-induced replication|leading strand elongation DNA-directed DNA polymerase activity|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity delta DNA polymerase complex|nucleus
YDR095C_d YDR095C hom 0.0341742861290804 0.0479824450706501 504 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL136W_d YKL136W hom 0.0341327465843663 0.0480209052279247 505 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C Unknown Unknown Unknown
YLL021W SPA2 hom FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH 0.0341021518387863 0.0482216263285705 506 Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate regulation of initiation of mating projection growth|regulation of termination of mating projection growth|pseudohyphal growth|invasive filamentous growth|mating projection assembly cytoskeletal regulatory protein binding incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YKL033W TTI1 het FT CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME 0.0339836431441814 0.0490395278893011 507 Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies biological_process molecular_function ASTRA complex|mitochondrion|cytoplasm
YPL092W SSU1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0339490745022286 0.0494399655181293 508 Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein sulfite transport sulfite transmembrane transporter activity integral to membrane|plasma membrane
YLR051C FCF2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0338852848285886 0.0496987300414271 509 Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus|nucleus
YKL162C_p YKL162C hom FT MITOCHONDRION 0.0338760780313616 0.0497267580914925 510 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion biological_process molecular_function mitochondrion
YPL015C HST2 hom FT GENE SILENCING|NUCLEUS 0.0338582834513414 0.0498468828559431 511 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export negative regulation of chromatin silencing at telomere|chronological cell aging|chromatin silencing at rDNA|negative regulation of mitotic recombination NAD-dependent histone deacetylase activity cytoplasm
YMR070W MOT3 hom FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|NUCLEUS 0.0337812584570787 0.0503696591710776 512 Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion cellular hyperosmotic response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ergosterol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding nucleus
YPR197C_d YPR197C hom FF 0.0337781734053314 0.0503906930218793 513 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL119C DBP1 hom FT TRANSLATION 0.0337568906616809 0.0505359990879545 514 Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress translational initiation RNA helicase activity cytoplasm
YDR334W SWR1 hom FF|FT CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.03369989884663 0.0509268346344372 515 Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A chromatin remodeling|histone exchange structural molecule activity Swr1 complex|nucleus
YNL259C ATX1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS 0.0336837601594196 0.0511418664107089 516 Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake copper ion transport|cellular response to oxidative stress|cellular iron ion homeostasis copper chaperone activity cytosol
YKR071C DRE2 het FT COFACTOR METABOLISM|MITOCHONDRION 0.033570256870175 0.0518253184358137 517 Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress iron-sulfur cluster assembly electron carrier activity cytosol|cytoplasm|mitochondrial intermembrane space
YNL217W_p YNL217W hom 0.0334843551687839 0.0524279324739727 518 Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate biological_process phosphatase activity fungal-type vacuole
YLR263W RED1 hom FT CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0334227420920218 0.0528637550910479 519 Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p synaptonemal complex assembly|meiotic recombination checkpoint|positive regulation of catalytic activity chromatin DNA binding|structural molecule activity lateral element
YHR038W RRF1 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0333776607246347 0.0531845537196388 520 Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria mitochondrial translation translation release factor activity mitochondrion
YLR274W MCM5 het FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0333649272888386 0.0532754586051309 521 Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase S phase of mitotic cell cycle|establishment of chromatin silencing|DNA replication initiation|regulation of DNA-dependent DNA replication initiation|negative regulation of chromatin silencing at telomere|pre-replicative complex assembly|double-strand break repair via break-induced replication|chromatin silencing at telomere DNA helicase activity|chromatin binding|DNA replication origin binding|single-stranded DNA binding replication fork protection complex|nuclear chromosome, telomeric region|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YCL037C SRO9 hom FT TRANSLATION 0.0332669419639716 0.0539793316940133 522 Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication cytoplasmic translation RNA binding polysome
YOR367W SCP1 hom FT CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.0331813892200016 0.0546002242605657 523 Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin actin filament organization|chronological cell aging actin filament binding|protein binding, bridging actin cortical patch
YNL288W CAF40 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0331604299498727 0.0547532392974555 524 Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter molecular_function CCR4-NOT core complex
YJR130C STR2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.0331301942404565 0.0552286707998999 525 Cystathionine gamma-synthase, converts cysteine into cystathionine sulfur compound metabolic process|transsulfuration cystathionine gamma-synthase activity nucleus|cytoplasm
YOR271C_p FSF1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION 0.0331209370146305 0.0551513461403817 526 Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis biological_process molecular_function mitochondrion|integral to membrane
YLR440C SEC39 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0330876272496905 0.0552875217927225 527 Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope retrograde vesicle-mediated transport, Golgi to ER|vesicle-mediated transport|ER-dependent peroxisome organization molecular_function Dsl1p complex|nuclear envelope|endoplasmic reticulum|peroxisome|endoplasmic reticulum membrane
YER043C SAH1 het FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0330573314731175 0.055547564627849 528 S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor methionine metabolic process|selenocysteine metabolic process adenosylhomocysteinase activity cytoplasm
YOR053W_d YOR053W hom 0.0330391222919531 0.0559018318209133 529 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C Unknown Unknown Unknown
YHR152W SPO12 hom FT CELL CYCLE|NUCLEUS 0.0328033383546007 0.057415617655346 530 Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis regulation of exit from mitosis|mitotic cell cycle|meiosis I molecular_function nucleolus|nucleus
YDL017W CDC7 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|PROTEIN PHOSPHORYLATION|GENE SILENCING|NUCLEUS 0.0328010190881943 0.0574332550482201 531 DDK (Dbf4-dependent kinase) catalytic subunit required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p negative regulation of exit from mitosis|regulation of chromatin silencing at telomere|protein phosphorylation|double-strand break repair via break-induced replication|DNA replication initiation protein serine/threonine kinase activity nucleus|Dbf4-dependent protein kinase complex
YKR102W FLO10 hom 0.0327756973577375 0.0576261130934766 532 Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth filamentous growth of a population of unicellular organisms|flocculation via cell wall protein-carbohydrate interaction|flocculation|invasive growth in response to glucose limitation mannose binding fungal-type cell wall
YPR012W_d YPR012W hom 0.0327710427998397 0.0577362031089392 533 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene Unknown Unknown Unknown
YOR317W FAA1 hom FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM|MITOCHONDRION 0.0326841717918872 0.0583276930848059 534 Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms ER foci upon DNA replication stress; FAA1 has a paralog, FAA4, that arose from the whole genome duplication long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process long-chain fatty acid-CoA ligase activity mitochondrial outer membrane|mitochondrion|lipid particle|plasma membrane
YDR306C_p YDR306C hom FT PROTEOLYSIS 0.0326285226007488 0.0587577231310346 535 F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YNL291C MID1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.0325774686296548 0.0593061195007862 536 N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer calcium ion transport stretch-activated, cation-selective, calcium channel activity|calcium channel activity endoplasmic reticulum|plasma membrane
YDR212W TCP1 het 0.0325095699966907 0.0596857589316209 537 Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein protein folding unfolded protein binding plasma membrane|chaperonin-containing T-complex
YER042W MXR1 hom FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS 0.0324989541936997 0.0599598585459573 538 Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan cellular response to oxidative stress peptide-methionine-(S)-S-oxide reductase activity nucleus|cytoplasm
YKR085C MRPL20 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0324984855432575 0.059772852435391 539 Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YJR111C_p YJR111C hom FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.032429602426705 0.0603164503240071 540 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria biological_process molecular_function mitochondrion
YDL131W LYS21 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS|MITOCHONDRION 0.0324042772440244 0.0605173336009952 541 Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication lysine biosynthetic process via aminoadipic acid homocitrate synthase activity nucleus
YKR053C YSR3 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0323989283850563 0.0605598323955382 542 Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication phospholipid dephosphorylation|sphingolipid biosynthetic process sphingosine-1-phosphate phosphatase activity integral to membrane|endoplasmic reticulum
YGR161W-C_p YGR161W-C hom 0.0323762993893352 0.0607399023315587 543 Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species biological_process molecular_function cellular_component
YJL152W_d YJL152W hom 0.0323019322320551 0.0613348039717663 544 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR192W GYL1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.032039262444217 0.0635142233671695 545 Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress ER to Golgi vesicle-mediated transport|regulation of exocytosis protein binding mitochondrion|incipient cellular bud site|cellular bud|cellular bud neck|cellular bud tip|cytoplasm|Golgi-associated vesicle|plasma membrane
YGR014W MSB2 hom FT SIGNALING|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.032026998706909 0.0635761591001524 546 Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate signal transduction involved in filamentous growth|osmosensory signaling pathway via Sho1 osmosensor|establishment of cell polarity|hyperosmotic response|response to osmotic stress osmosensor activity site of polarized growth|integral to plasma membrane
YDR485C VPS72 hom FF|FT CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.0318788684433511 0.0648115401439902 547 Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting chromatin remodeling|histone exchange histone binding Swr1 complex|nucleus|cytoplasm
YGL202W ARO8 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0318686583771057 0.0648974146639397 548 Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis aromatic amino acid family metabolic process aromatic-amino-acid:2-oxoglutarate aminotransferase activity|2-aminoadipate transaminase activity cytoplasm
YLR436C ECM30 hom FT CELL WALL ORG/BIOGENESIS 0.0318269388044685 0.0652492839524036 549 Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm fungal-type cell wall organization molecular_function cytoplasm
YNR070W_p PDR18 hom FT NUCLEOTIDE METABOLISM|MITOCHONDRION 0.0318213105548166 0.0652968736455979 550 Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies transport ATPase activity, coupled to transmembrane movement of substances mitochondrion|integral to membrane|membrane
YPL100W ATG21 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.0317846677672743 0.0656074068768215 551 Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein piecemeal microautophagy of nucleus|vesicle organization|mitochondrion degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway|protein lipidation phosphatidylinositol binding endosome|cytosol|fungal-type vacuole membrane
YIL018W RPL2B hom FT TRANSLATION|RIBOSOME 0.0317489401988442 0.065911354705922 552 Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YLR104W_p LCL2 hom FT PROTEOLYSIS 0.0317277260000419 0.066092380085183 553 Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD) ER-associated protein catabolic process molecular_function cellular_component
YJL179W PFD1 hom FT CYTOSKELETON ORGANIZATION 0.031711017079309 0.0662352490546228 554 Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin protein folding|cytoskeleton organization unfolded protein binding prefoldin complex
YDL155W CLB3 hom FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0316855847890153 0.0664531949240888 555 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity nucleus|cytoplasm
YDR415C_p YDR415C hom FT PROTEOLYSIS 0.0316579111786278 0.0666910185587746 556 Putative aminopeptidase biological_process molecular_function cellular_component
YBR256C RIB5 het FT OXIDATION-REDUCTION PROCESS 0.0316200844097674 0.0670172300487935 557 Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway riboflavin biosynthetic process riboflavin synthase activity cellular_component
YKL123W_d YKL123W hom 0.031544388577184 0.0676739605767054 558 Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4 Unknown Unknown Unknown
YGR196C FYV8 hom 0.0312042272720836 0.0706908069668433 559 Protein of unknown function, required for survival upon exposure to K1 killer toxin biological_process molecular_function cytoplasm
YLL043W FPS1 hom FT ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0311728361978276 0.0709746816202215 560 Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress conjugation with cellular fusion|transport|arsenite transport|glycerol transport|acetate transport|response to arsenic-containing substance glycerol transmembrane transporter activity|transporter activity integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YJR042W NUP85 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0311487151590648 0.0711934463269917 561 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75 positive regulation of transcription, DNA-dependent|mRNA export from nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|nuclear pore distribution structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore outer ring
YJL092W SRS2 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.0311339037798677 0.071328051056598 562 DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability DNA repair|double-strand break repair via nonhomologous end joining|DNA duplex unwinding DNA helicase activity nucleus
YBL039C URA7 hom FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM 0.0310807764843398 0.0720247226983146 563 Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process CTP synthase activity cytosol
YDR442W_d YDR442W hom 0.0308931542580399 0.0736742765135233 564 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR225W_p YBR225W hom 0.0308116592468151 0.0743085644189193 565 Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components biological_process molecular_function cellular_component
YGR195W SKI6 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0307389323011101 0.0750385348514972 566 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4) nuclear mRNA surveillance|U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|U1 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YJR107W_p YJR107W hom FT LIPID METABOLISM 0.0306889585483691 0.075469866171093 567 Putative lipase biological_process lipase activity cellular_component
YMR179W SPT21 hom FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING|NUCLEUS 0.0306459114320412 0.0758807780631694 568 Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette molecular_function nucleus
YJL062W LAS21 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.0305756897653125 0.0765550027013964 569 Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity GPI anchor biosynthetic process mannose-ethanolamine phosphotransferase activity|transferase activity integral to endoplasmic reticulum membrane|integral to membrane|integral to plasma membrane
YHR139C-A_d YHR139C-A hom 0.0305309394881948 0.0769872084140824 570 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIR012W SQT1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RIBOSOME 0.0305182239743574 0.0771103790058249 571 Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress ribosomal large subunit assembly molecular_function cytosol|cytosolic ribosome|cytoplasm
YDR128W MTC5 hom 0.030473284916349 0.0776797634111179 572 Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress biological_process molecular_function fungal-type vacuole membrane|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YJL180C ATP12 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0304692110407159 0.0776309006860019 573 Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency mitochondrial proton-transporting ATP synthase complex assembly protein domain specific binding mitochondrion
YBR118W TEF2 hom FT TRANSLATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|CYTOSKELETON|RIBOSOME 0.030443783099868 0.0778346851086006 574 Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication translational elongation|tRNA export from nucleus GDP binding|GTP binding|translation elongation factor activity ribosome|eukaryotic translation elongation factor 1 complex|cytoplasm
YNR051C BRE5 hom FT VESICLE-MEDIATED TRANSPORT 0.030375817740652 0.0785008118935053 575 Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown molecular_function cytoplasm
YOR377W ATF1 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM 0.030322353364296 0.079028067438894 576 Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism Unknown|fermentation alcohol O-acetyltransferase activity lipid particle
YMR189W GCV2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.0303137874961749 0.0793367123222947 577 P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm glycine decarboxylation via glycine cleavage system|one-carbon metabolic process glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YJR013W GPI14 het FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0302832530508456 0.0794154872586028 578 Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M fungal-type cell wall organization|GPI anchor biosynthetic process mannosyltransferase activity integral to membrane|endoplasmic reticulum membrane
YGR046W TAM41 het FT PROTEIN LOCALIZATION|LIPID METABOLISM|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0302790730462484 0.0794569954033239 579 Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition cardiolipin biosynthetic process|protein import into mitochondrial matrix molecular_function extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YGR200C ELP2 hom FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS 0.0302423340667518 0.0798225786081377 580 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification molecular_function Elongator holoenzyme complex|nucleus|cytoplasm
YLR363W-A YLR363W-A hom FT NUCLEUS 0.0301743098446017 0.0805030827549764 581 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress biological_process molecular_function nucleus
YGR217W CCH1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0300944962318177 0.0813075234025021 582 Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together calcium ion transport voltage-gated calcium channel activity|calcium channel activity integral to membrane|plasma membrane
YOL088C MPD2 hom FT ENDOPLASMIC RETICULUM 0.0300896574726873 0.0813565021202794 583 Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p protein folding protein disulfide isomerase activity|protein disulfide oxidoreductase activity endoplasmic reticulum
YLL055W YCT1 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.0300623123125321 0.0816337443313752 584 High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene cysteine transport ion transmembrane transporter activity|cysteine transmembrane transporter activity integral to membrane|endoplasmic reticulum
YJL124C LSM1 hom FF|FT RNA PROCESSING|NUCLEUS 0.0300485651688489 0.0821842730232526 585 Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay RNA binding|RNA cap binding mRNA cap binding complex|cytoplasmic mRNA processing body|cytoplasm
YML111W BUL2 hom FT UBIQUITIN LIGASE COMPLEX 0.0300319992255308 0.0819419721542888 586 Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication protein polyubiquitination|protein monoubiquitination ubiquitin-ubiquitin ligase activity ubiquitin ligase complex|cytoplasm
YOR158W PET123 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0300163884702416 0.0821010722396254 587 Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YDR058C TGL2 hom FT PROTEIN LOCALIZATION|LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.0299375594836343 0.0829083022228692 588 Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli triglyceride catabolic process triglyceride lipase activity mitochondrion
YKL072W STB6 hom 0.0298572171717466 0.0837376319612479 589 Protein that binds Sin3p in a two-hybrid assay biological_process molecular_function cellular_component
YEL057C_p YEL057C hom 0.0298351044214362 0.0840132627488754 590 Protein of unknown function involved in telomere maintenance; target of UME6 regulation biological_process molecular_function cellular_component
YEL067C_p YEL067C hom FT MITOCHONDRION 0.0297901681594618 0.0844348705890981 591 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YKL121W_p DGR2 hom 0.0297580376557912 0.0847706540349853 592 Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds biological_process molecular_function cellular_component
YGR102C GTF1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION 0.0296939704613947 0.0856768566591761 593 Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria glutaminyl-tRNAGln biosynthesis via transamidation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YLR230W_d YLR230W het 0.0296464310974762 0.0859454078678989 594 Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity Unknown Unknown Unknown
YOR264W DSE3 hom FT CELL CYCLE|SITE OF POLARIZED GROWTH 0.0296199339680967 0.0862262352717733 595 Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular bud neck
YER153C PET122 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0295982154180923 0.0864569694487994 596 Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis translation initiation factor activity mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YER092W IES5 hom FT NUCLEUS 0.0295909544182602 0.086534220150728 597 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions biological_process molecular_function nucleus
YER165W PAB1 het FF|FT RNA PROCESSING|TRANSLATION|RNA LOCALIZATION|NUCLEUS|RIBOSOME 0.0295602324222582 0.0868616921679318 598 Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation poly(A) RNA binding ribosome|nucleus|cytoplasmic stress granule|cytoplasm
YOR066W MSA1 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS 0.0295590488762873 0.0868743278021933 599 Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation G1/S transition of mitotic cell cycle|regulation of transcription involved in G1 phase of mitotic cell cycle|regulation of cell size molecular_function nucleus|cytoplasm
YDR414C ERD1 hom FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.029549198436451 0.0869795494599711 600 Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p) protein retention in ER lumen|protein glycosylation molecular_function integral to membrane|membrane
YJR106W ECM27 hom FT CELL WALL ORG/BIOGENESIS 0.029496129563547 0.0875481976563304 601 Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p fungal-type cell wall organization molecular_function integral to membrane
YGL075C MPS2 het FT CELL CYCLE|CYTOSKELETON ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON 0.0294906627056898 0.0876069465372704 602 Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p mitotic anaphase|spindle pole body duplication associated with nuclear envelope structural constituent of cytoskeleton nuclear envelope|spindle pole body
YGR277C CAB4 het FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.0294723757606207 0.0878510098761376 603 Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved coenzyme A biosynthetic process pantetheine-phosphate adenylyltransferase activity nucleus|cytoplasm
YPL217C BMS1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM|NUCLEUS|MITOCHONDRION 0.0294481858695191 0.0880645021590439 604 GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p ribosome assembly|rRNA processing U3 snoRNA binding|GTP binding|GTPase activity mitochondrion|nucleolus|nucleus|90S preribosome|cytoplasm
YJL151C SNA3 hom FT VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM 0.029437834168494 0.0881763008999473 605 Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles cellular protein catabolic process|endosome transport via multivesicular body sorting pathway ubiquitin protein ligase binding fungal-type vacuole lumen|integral to membrane
YGR201C_p YGR201C hom 0.0294367595503419 0.0881879133649232 606 Putative protein of unknown function biological_process molecular_function cellular_component
YGR067C_p YGR067C hom FT NUCLEUS 0.0294356942242401 0.0885319947700722 607 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p biological_process sequence-specific DNA binding cellular_component
YPL157W TGS1 hom FT CELL CYCLE|RNA PROCESSING|NUCLEUS 0.0294158533110887 0.0884140742578055 608 Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs meiosis|RNA methylation|nucleologenesis|7-methylguanosine cap hypermethylation|regulation of telomere maintenance via telomerase RNA methyltransferase activity nucleolus
YBR267W REI1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION|RIBOSOME 0.0294032555247807 0.0885505809145869 609 Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network ribosomal large subunit biogenesis|nucleocytoplasmic transport|mitotic cell cycle|budding cell bud growth sequence-specific DNA binding cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YDR187C_d YDR187C het FF 0.029395067731584 0.0886393929250513 610 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W Unknown Unknown Unknown
YDR257C RKM4 hom FT NUCLEUS 0.0293268907423795 0.0893816898464187 611 Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein peptidyl-lysine monomethylation protein-lysine N-methyltransferase activity nucleus
YLR177W_p YLR177W hom 0.0293146170158184 0.0895158536614951 612 Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YMR116C ASC1 hom FT SIGNALING|TRANSLATION|RIBOSOME 0.0293122205066894 0.0895420687511849 613 G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation negative regulation of translation|glucose mediated signaling pathway|G-protein coupled receptor signaling pathway|invasive growth in response to glucose limitation G-protein alpha-subunit binding|GDP-dissociation inhibitor activity|signal transducer activity cytosolic small ribosomal subunit|cytoplasm
YER049W TPA1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|NUCLEUS 0.0292835111138996 0.0903367881268811 614 Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|translational termination poly(A) RNA binding nucleus
YGR110W CLD1 hom FT LIPID METABOLISM|MITOCHONDRION 0.0292739347797736 0.090057584552571 615 Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 cardiolipin acyl-chain remodeling|cardiolipin metabolic process phospholipase A2 activity mitochondrion
YCR107W AAD3 hom FT OXIDATION-REDUCTION PROCESS 0.0292529904203148 0.0901919445489826 616 Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YLR412W BER1 hom FT CYTOSKELETON 0.0292461319862387 0.0902674401427061 617 Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene biological_process molecular_function cytoplasm
YGR141W VPS62 hom FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT 0.0292147653945352 0.0906133622501286 618 Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins protein targeting to vacuole molecular_function cellular_component
YLR093C NYV1 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION 0.0290810041181792 0.0921005116813676 619 v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane vesicle-mediated transport|vacuole fusion, non-autophagic|vesicle fusion SNAP receptor activity SNARE complex|fungal-type vacuole membrane
YJR010W MET3 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION 0.0290667084068452 0.0922606030260854 620 ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process sulfate adenylyltransferase (ATP) activity mitochondrion|cytoplasm
YIL123W SIM1 hom FT CELL WALL ORG/BIOGENESIS 0.0290645744913952 0.0922845189520387 621 Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated fungal-type cell wall organization molecular_function fungal-type cell wall
YMR305C SCW10 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOPLASMIC RETICULUM 0.0289892241130853 0.0931322061494472 622 Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p conjugation with cellular fusion glucosidase activity fungal-type cell wall|extracellular region|endoplasmic reticulum|cytoplasm
YEL040W UTR2 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0289657119712486 0.0934468600052238 623 Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck cell wall chitin metabolic process|fungal-type cell wall organization transferase activity, transferring glycosyl groups cellular bud neck septin ring|fungal-type cell wall
YGR096W TPC1 hom FT MITOCHONDRION 0.0289634356400041 0.0934726312575613 624 Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family thiamine pyrophosphate transport thiamine transmembrane transporter activity integral to membrane|integral to mitochondrial inner membrane
YBR077C SLM4 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|SIGNALING 0.0289074248311251 0.0945019304349295 625 Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 signal transduction|microautophagy phosphatidylinositol-3,4-bisphosphate binding fungal-type vacuole membrane|EGO complex|late endosome membrane|cytoplasm
YIL013C PDR11 hom FT NUCLEOTIDE METABOLISM 0.0288921585161533 0.094479129530803 626 ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth sterol transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YFL044C OTU1 hom FT PROTEOLYSIS|NUCLEUS 0.0288784855313113 0.0944384672044326 627 Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress protein deubiquitination|regulation of transcription, DNA-dependent ubiquitin-specific protease activity nucleus|cytoplasm
YGR101W PCP1 hom FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0288518083056402 0.0946941995069415 628 Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases signal peptide processing|regulation of mitochondrion organization serine-type endopeptidase activity integral to membrane|mitochondrial inner membrane
YDL048C STP4 hom FT NUCLEUS|MITOCHONDRION 0.0288153988841177 0.09511155969405 629 Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress biological_process sequence-specific DNA binding mitochondrion|nucleus|cytoplasm
YOR202W HIS3 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0286978822094738 0.0964687068456896 630 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p histidine biosynthetic process imidazoleglycerol-phosphate dehydratase activity cellular_component
YIL116W HIS5 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0286432872817166 0.0973040307026242 631 Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts histidine biosynthetic process histidinol-phosphate transaminase activity intracellular
YJL034W KAR2 het FT PROTEIN LOCALIZATION|PROTEOLYSIS|ENDOPLASMIC RETICULUM 0.0286066160306944 0.0975333461064594 632 ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p karyogamy involved in conjugation with cellular fusion|posttranslational protein targeting to membrane, translocation|ER-associated protein catabolic process|SRP-dependent cotranslational protein targeting to membrane, translocation|response to unfolded protein unfolded protein binding|ATPase activity endoplasmic reticulum|luminal surveillance complex
YDL125C HNT1 hom FT NUCLEOTIDE METABOLISM|NUCLEUS 0.0285669081649997 0.0979994675220334 633 Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress nucleotide metabolic process hydrolase activity|nucleotide binding nucleus|cytoplasm
YDR489W SLD5 het FT RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0284534487038552 0.0993411501352739 634 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery double-strand break repair via break-induced replication|DNA-dependent DNA replication molecular_function GINS complex|replication fork protection complex|DNA replication preinitiation complex
YJL187C SWE1 hom FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH 0.0284212935472968 0.0997240443777481 635 Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate negative regulation of spindle pole body separation|G2/M transition size control checkpoint|protein phosphorylation|re-entry into mitotic cell cycle|G2/M transition of mitotic cell cycle|cell shape checkpoint|regulation of cyclin-dependent protein kinase activity|regulation of cell size|regulation of meiosis protein tyrosine kinase activity|protein kinase activity nucleus|cellular bud neck
YLR152C_p YLR152C hom 0.0283886486303058 0.100418171950127 636 Putative protein of unknown function; YLR152C is not an essential gene biological_process molecular_function integral to membrane
YDR514C YDR514C hom FT NUCLEUS|MITOCHONDRION 0.0283592430296543 0.100466249286424 637 Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication biological_process molecular_function mitochondrion|nucleus
YPL186C UIP4 hom FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.0283431929313706 0.100658944021387 638 Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope biological_process molecular_function mitochondrial outer membrane|nuclear envelope|endoplasmic reticulum
YLR170C APS1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0283373064509489 0.100729689843481 639 Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YOR327C SNC2 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0282896366080528 0.101304063060633 640 Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion SNAP receptor activity SNARE complex|trans-Golgi network|endosome|transport vesicle membrane
YMR139W RIM11 hom FT PROTEOLYSIS|PROTEIN PHOSPHORYLATION 0.0282062991712971 0.102314455301729 641 Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress proteolysis|ascospore formation|protein phosphorylation|response to stress protein serine/threonine kinase activity|protein kinase activity cytoplasm
YLR085C ARP6 hom FF|FT CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.028069750512966 0.104038891271769 642 Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A chromatin remodeling|histone exchange nucleosome binding Swr1 complex|cytoplasm
YLR237W THI7 hom FT PLASMA MEMBRANE 0.0279926723805639 0.104992945766083 643 Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia thiamine transport thiamine transmembrane transporter activity integral to membrane|plasma membrane
YPR184W GDB1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS|MITOCHONDRION 0.0279904881380257 0.104968247157857 644 Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress glycogen catabolic process 4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity mitochondrion|cytoplasm
YMR165C PAH1 hom FT LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0279751184139762 0.105159310244887 645 Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2 plasmid maintenance|vacuole fusion, non-autophagic|lipid particle organization|aerobic respiration|phospholipid biosynthetic process phosphatidate phosphatase activity cytosol|nuclear membrane|vacuole|cytoplasm|extrinsic to membrane
YDR465C RMT2 hom FT NUCLEUS 0.0279105929598194 0.106591217461789 646 Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress peptidyl-arginine methylation protein-arginine N5-methyltransferase activity nucleus|cytoplasm
YNL190W_p YNL190W hom 0.0278753299689259 0.106406512522295 647 Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site cellular response to water deprivation molecular_function fungal-type cell wall
YHR044C DOG1 hom FT CARBOHYDRATE METABOLISM 0.0278308603031705 0.106966077371578 648 2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified glucose metabolic process 2-deoxyglucose-6-phosphatase activity cellular_component
YBR031W RPL4A hom FT TRANSLATION|RIBOSOME 0.0278248082494444 0.107042410618339 649 Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YCR105W ADH7 hom FT OXIDATION-REDUCTION PROCESS 0.0278167935763686 0.10714356434436 650 NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance alcohol metabolic process alcohol dehydrogenase (NADP+) activity cellular_component
YHR166C CDC23 het FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|CHROMOSOME|UBIQUITIN LIGASE COMPLEX 0.0277892374887432 0.10749192920141 651 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity|cyclin binding anaphase-promoting complex
YMR284W YKU70 hom FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME 0.0277298209517821 0.108404067828081 652 Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair chromatin assembly or disassembly|chromatin silencing|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette damaged DNA binding|RNA binding nuclear chromatin|nuclear telomeric heterochromatin|nuclear envelope|Ku70:Ku80 complex
YEL044W IES6 hom FT NUCLEUS 0.0277186337046611 0.108546639538513 653 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes biological_process molecular_function nucleus
YMR080C NAM7 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RNA LOCALIZATION|GENE SILENCING|NUCLEUS 0.0277141338046147 0.108709558141318 654 ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|intracellular mRNA localization|translational frameshifting|regulation of translational termination|chromatin silencing at silent mating-type cassette|protein ubiquitination RNA-dependent ATPase activity|ATP-dependent RNA helicase activity|nucleic acid binding mitochondrion|polysome|cytoplasm
YAL021C CCR4 hom FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|NUCLEUS|RNA POL II, HOLOENZYME 0.0277018474396618 0.108602650243151 655 Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|DNA replication checkpoint|nuclear-transcribed mRNA poly(A) tail shortening|traversing start control point of mitotic cell cycle|replication fork protection|transcription elongation from RNA polymerase II promoter|DNA replication 3'-5'-exoribonuclease activity CCR4-NOT core complex|cytoplasmic mRNA processing body|Cdc73/Paf1 complex|cytoplasm
YER076C_p YER076C hom FT MITOCHONDRION 0.0276657280412404 0.109064367782706 656 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization biological_process molecular_function mitochondrion
YFL015C_d YFL015C hom 0.0276587512980787 0.10915373067408 657 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene Unknown Unknown Unknown
YIR018C-A_p YIR018C-A hom 0.0276355585559656 0.109451215196786 658 Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YOR103C OST2 het FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0276081254349706 0.109803916130519 659 Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins protein N-linked glycosylation dolichyl-diphosphooligosaccharide-protein glycotransferase activity oligosaccharyltransferase complex|integral to membrane
YPR057W BRR1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS 0.0276069084597831 0.109819583257107 660 snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed spliceosomal complex assembly RNA binding small nuclear ribonucleoprotein complex
YGL163C RAD54 hom FF|FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS 0.0275042737488957 0.111147250968494 661 DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|DNA translocase activity nucleus
YOR242C SSP2 hom FT CELL WALL ORG/BIOGENESIS 0.0275009877850644 0.111403348068904 662 Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis ascospore wall assembly|ascospore formation molecular_function ascospore wall
YOR033C EXO1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS 0.0274641794842533 0.111669331781416 663 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress mismatch repair|telomeric 3' overhang formation|DNA double-strand break processing|meiotic DNA double-strand break processing|telomere maintenance|gene conversion at mating-type locus, DNA double-strand break processing 5'-3' exonuclease activity|5'-flap endonuclease activity nucleus
YLR137W RKM5 hom 0.0274586756223703 0.11174115012231 664 Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species protein methylation S-adenosylmethionine-dependent methyltransferase activity cellular_component
YBR135W CKS1 het FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|NUCLEUS 0.0274208259320787 0.112236027028074 665 Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters positive regulation of transcription, DNA-dependent|regulation of cell cycle|transcription, DNA-dependent|chromatin remodeling ubiquitin binding|protein kinase activator activity|histone binding cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YJR121W ATP2 hom FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION 0.0273715876852039 0.112882390558836 666 Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|mitochondrial proton-transporting ATP synthase, catalytic core|integral to membrane
YMR191W SPG5 hom 0.0273634573726881 0.112989400847555 667 Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources biological_process molecular_function cellular_component
YGR039W_d YGR039W hom 0.0273337031190926 0.113381704547115 668 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722 Unknown Unknown Unknown
YPL211W NIP7 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|RIBOSOME 0.0273270395543715 0.113469709098995 669 Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p ribosomal large subunit assembly|ribosomal large subunit biogenesis|rRNA processing molecular_function cytosolic large ribosomal subunit|nucleolus|preribosome, large subunit precursor
YKL172W EBP2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0273078064545857 0.113885735563639 670 Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering nuclear division|rRNA processing molecular_function nuclear periphery|nucleolus|preribosome, large subunit precursor
YDL147W RPN5 het FT PROTEOLYSIS|NUCLEUS 0.0272533001122429 0.114447167626979 671 Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein cullin deneddylation|ubiquitin-dependent protein catabolic process molecular_function proteasome complex|signalosome|proteasome storage granule|proteasome regulatory particle, lid subcomplex
YOL025W LAG2 hom FT MITOCHONDRION 0.0272168594482113 0.114932648835558 672 Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1 replicative cell aging|negative regulation of ubiquitin-protein ligase activity molecular_function mitochondrion
YJR131W MNS1 hom FT CARBOHYDRATE METABOLISM|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0272093298219692 0.115033163956464 673 Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation ER-associated protein catabolic process|protein deglycosylation involved in glycoprotein catabolic process mannosyl-oligosaccharide 1,2-alpha-mannosidase activity endoplasmic reticulum
YIL005W EPS1 hom FT PROTEIN LOCALIZATION|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0272010973575211 0.115143140544954 674 ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family protein retention in ER lumen|ER-associated protein catabolic process unfolded protein binding|protein disulfide isomerase activity|chaperone binding endoplasmic reticulum membrane
YDR145W TAF12 het FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE 0.0271982231956859 0.115181555618339 675 Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter TBP-class protein binding|chromatin binding|RNA polymerase II activating transcription factor binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YNL131W TOM22 het FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0271610771115934 0.115678944674702 676 Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes protein import into mitochondrial matrix|protein import into mitochondrial outer membrane protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YHR203C RPS4B hom FT TRANSLATION|RIBOSOME 0.0270658015177726 0.116962409683444 677 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YKR078W YKR078W hom 0.0270263993781715 0.118430323105904 678 Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) biological_process phosphatidylinositol-3-phosphate binding cytoplasm
YKL174C TPO5 hom FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0270158979772564 0.117639110269076 679 Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles polyamine transport polyamine transmembrane transporter activity integral to membrane|Golgi apparatus
YKL135C APL2 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE 0.0269898874677287 0.117993032716515 680 Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YFR045W_p YFR045W hom FT MITOCHONDRION 0.0269586198577231 0.1184195925659 681 Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white transport transporter activity integral to membrane|mitochondrial inner membrane
YAL036C RBG1 hom FT TRANSLATION|RIBOSOME 0.0269364907069887 0.118722213261449 682 Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid cytoplasmic translation GTP binding polysomal ribosome|polysome|cytoplasm
YPL257W_p YPL257W hom FT CELL CYCLE 0.0269064667390943 0.119133765725707 683 Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene biological_process molecular_function integral to membrane
YKL039W PTM1 hom FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0268918341514677 0.11933474604583 684 Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YPL113C_p YPL113C hom FT OXIDATION-REDUCTION PROCESS 0.0268728173771284 0.119596340400155 685 Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor cellular_component
YCR065W HCM1 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|CHROMOSOME 0.0268280923456596 0.12026863460746 686 Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role positive regulation of transcription involved in S-phase of mitotic cell cycle|cellular response to oxidative stress|mitochondrion organization|spindle pole body organization|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nuclear chromatin|nucleus|cytoplasm
YJL038C LOH1 hom 0.0268115966755409 0.120496877375209 687 Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 chromosome organization molecular_function cellular_component
YIL095W PRK1 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0267483060725895 0.121320225384257 688 Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication regulation of endocytosis|actin filament organization|protein phosphorylation|actin cortical patch assembly|cytokinesis protein serine/threonine kinase activity|protein kinase activity mating projection tip|actin cortical patch
YMR203W TOM40 het FF|FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION 0.026741656888715 0.12174648701091 689 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore protein import into mitochondrial matrix protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YDR351W SBE2 hom FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS|GOLGI APPARATUS 0.0267394826151882 0.121443121344802 690 Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth fungal-type cell wall organization molecular_function Golgi apparatus
YBR201W DER1 hom FT PROTEIN LOCALIZATION|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX 0.0267078934186051 0.121883903924882 691 Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p ER-associated protein catabolic process molecular_function integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YJR041C URB2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0265821821863485 0.123930712154634 692 Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis rRNA metabolic process|ribosome biogenesis molecular_function nucleolus
YAL065C_p YAL065C hom 0.0265512189365642 0.124088577292185 693 Putative protein of unknown function; has homology to FLO1; possible pseudogene biological_process molecular_function cellular_component
YGL030W RPL30 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0265252048825404 0.124626212271323 694 Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog cytoplasmic translation|negative regulation of mRNA splicing, via spliceosome|negative regulation of translation|rRNA processing structural constituent of ribosome|RNA binding|pre-mRNA 5'-splice site binding cytosolic large ribosomal subunit|cytoplasm
YLR409C UTP21 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0264740731111088 0.125185515730343 695 Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma ribosomal small subunit biogenesis|rRNA processing molecular_function small-subunit processome|nucleolus|nucleus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YLR303W MET17 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0264390271083279 0.125686324848248 696 Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis methionine metabolic process|cysteine biosynthetic process O-acetylhomoserine aminocarboxypropyltransferase activity|cysteine synthase activity plasma membrane|cytoplasm
YDR118W APC4 het FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0264018756786061 0.126218922954917 697 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YJL202C_d YJL202C het 0.0263919934446724 0.126360888789049 698 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex Unknown Unknown Unknown
YPR078C_p YPR078C hom 0.0263362272467318 0.127391343621556 699 Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible biological_process molecular_function cellular_component
YDR075W PPH3 hom FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0263273086291053 0.12729320680977 700 Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes Unknown|signal transduction involved in meiotic recombination checkpoint|double-strand break repair via homologous recombination|protein dephosphorylation|positive regulation of nitrogen compound metabolic process protein serine/threonine phosphatase activity condensed nuclear chromosome|nucleus|cytoplasm
YDR455C_d YDR455C hom FF 0.0263066353385118 0.127592301416835 701 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W Unknown Unknown Unknown
YBL022C PIM1 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION 0.0262852324613156 0.127902526823304 702 ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria chaperone-mediated protein complex assembly|misfolded or incompletely synthesized protein catabolic process ATP-dependent peptidase activity mitochondrion|mitochondrial matrix
YKL155C RSM22 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0262048148638874 0.129244717952523 703 Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase mitochondrial translation structural constituent of ribosome|S-adenosylmethionine-dependent methyltransferase activity mitochondrion|mitochondrial small ribosomal subunit
YDL162C_d YDL162C hom 0.0261924790189054 0.1292537279494 704 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly Unknown Unknown Unknown
YKL176C LST4 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM 0.0261653890301579 0.129650449661673 705 Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport protein transporter activity vesicle coat
YNL068C FKH2 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.026152574773058 0.129838438100953 706 Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|negative regulation of transcription involved in G1 phase of mitotic cell cycle|Unknown|chromatin remodeling|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity nucleus
YLR200W YKE2 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEUS 0.0261177059338975 0.130351043763557 707 Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin protein folding|tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YKL068W NUP100 hom FT PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0260813774722014 0.130886775441142 708 FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; homologous to Nup116p positive regulation of transcription, DNA-dependent|mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|protein import into nucleus|protein targeting to nuclear inner membrane|mRNA export from nucleus in response to heat stress nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore
YML037C_p YML037C hom 0.0260812611853741 0.130945925023064 709 Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene biological_process molecular_function clathrin-coated vesicle
YPR019W MCM4 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0260582143368374 0.131229249677064 710 Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|DNA unwinding involved in replication|double-strand break repair via break-induced replication|DNA replication initiation|pre-replicative complex assembly four-way junction helicase activity|DNA helicase activity|DNA replication origin binding|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding|ATP-dependent 3'-5' DNA helicase activity replication fork protection complex|nuclear replication fork|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YFR008W FAR7 hom FT CELL CYCLE|SIGNALING 0.0260536372230886 0.131527214199562 711 Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress re-entry into mitotic cell cycle after pheromone arrest molecular_function cellular_component
YDR363W ESC2 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS 0.0260487507999812 0.131369370713705 712 Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member intra-S DNA damage checkpoint|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette|mitotic sister chromatid cohesion molecular_function nucleus
YFL013C IES1 hom FT CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.0260384698440454 0.131982935301517 713 Subunit of the INO80 chromatin remodeling complex nucleosome mobilization molecular_function nucleus|Ino80 complex
YDR020C_p DAS2 hom FT NUCLEOTIDE METABOLISM|NUCLEUS 0.0259876574333813 0.132276736138877 714 Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases biological_process molecular_function nucleus|cytoplasm
YDR312W SSF2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.0259678311686247 0.133035036653449 715 Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication conjugation with cellular fusion|ribosomal large subunit assembly rRNA binding nucleolus
YJL077W-B_p YJL077W-B hom 0.0259345698670933 0.133069132306698 716 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YFR019W FAB1 hom FT LIPID METABOLISM|MITOCHONDRION 0.0258493991878933 0.134580573847559 717 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-phosphate 5-kinase activity|phosphatidylinositol-3-phosphate binding endosome membrane|mitochondrion|fungal-type vacuole membrane|PAS complex
YOR017W PET127 hom FT RNA PROCESSING|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0258323776387314 0.134604809105001 718 Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane mitochondrial RNA 5'-end processing molecular_function mitochondrial envelope|mitochondrion
YGR239C PEX21 hom FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION 0.0257963610761307 0.135149293752687 719 Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress protein import into peroxisome matrix|positive regulation of protein binding protein binding cytosol|peroxisome
YER178W PDA1 hom FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.0257920108064107 0.135215174445129 720 E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose acetyl-CoA biosynthetic process from pyruvate pyruvate dehydrogenase (acetyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YDR352W YPQ2 hom 0.0257104051174373 0.136631107774735 721 Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YFR057W_p YFR057W hom 0.0256740273821584 0.137069964480447 722 Putative protein of unknown function biological_process molecular_function cellular_component
YLR098C CHA4 hom FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.0256699894773668 0.13707319330571 723 DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain positive regulation of transcription, DNA-dependent|cellular amino acid catabolic process sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YOR102W_d YOR102W het 0.0256676109994224 0.137109605009598 724 Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex Unknown Unknown Unknown
YHR130C_d YHR130C hom 0.0256180622414236 0.137869835298635 725 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL279W PRM1 hom FT MEMBRANE ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.025597043111839 0.138252094741492 726 Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p plasma membrane fusion involved in cytogamy|response to pheromone molecular_function integral to membrane|mating projection tip
YGR144W THI4 hom FT MITOCHONDRION ORGANIZATION|NUCLEUS 0.0254899307146026 0.139850824935041 727 Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents thiamine biosynthetic process|mitochondrial genome maintenance|thiazole biosynthetic process ferrous iron binding cytosol
YMR177W MMT1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION 0.0254763612129895 0.140061893060726 728 Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p cellular iron ion homeostasis molecular_function mitochondrion|integral to membrane
YOR214C_p YOR214C hom 0.0254528789359123 0.140427729066006 729 Putative protein of unknown function; YOR214C is not an essential gene biological_process molecular_function fungal-type cell wall
YJL054W TIM54 het FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0254038858634093 0.141193368509059 730 Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane protein import into mitochondrial inner membrane protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YNL257C SIP3 hom FT TRANSCRIPTION FROM RNA POL II 0.0253721010299055 0.141691798699381 731 Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter transcription cofactor activity integral to membrane
YIL022W TIM44 het FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0253561152459113 0.141942988042119 732 Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex) protein import into mitochondrial matrix protein binding, bridging|chaperone binding mitochondrion|integral to membrane|presequence translocase-associated import motor
YDR144C MKC7 hom FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS|PLASMA MEMBRANE 0.0252582469795134 0.143488280812439 733 GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p proteolysis|fungal-type cell wall organization aspartic-type endopeptidase activity fungal-type cell wall
YNL202W SPS19 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS 0.0252431370239372 0.143728004825325 734 Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate fatty acid catabolic process|ascospore formation 2,4-dienoyl-CoA reductase (NADPH) activity peroxisomal matrix
YFR007W YFH7 hom 0.025170988226974 0.145116826544122 735 Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases phosphorylation ATPase activity|kinase activity cellular_component
YMR303C ADH2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM 0.0251286244385417 0.14555477240311 736 Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 ethanol metabolic process|NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity cytoplasm
YMR186W HSC82 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION 0.0251139340206886 0.145790402294004 737 Cytoplasmic chaperone of the Hsp90 family; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication protein folding|proteasome assembly|protein refolding|telomere maintenance|'de novo' protein folding|box C/D snoRNP assembly|response to stress unfolded protein binding|ATPase activity, coupled|ATPase activity mitochondrion|plasma membrane|cytoplasm
YDR326C YSP2 hom FT MITOCHONDRION 0.0251045863824892 0.145940487481584 738 Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication apoptotic process molecular_function mitochondrion
YBL056W PTC3 hom FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0250746673837932 0.146421660065131 739 Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YKR023W_p YKR023W hom FT NUCLEUS|MITOCHONDRION 0.0250713759817912 0.14647466805843 740 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion|cytoplasm
YNL213C RRG9 hom FT MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0250444207853953 0.146909333554117 741 Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies mitochondrion organization|mitochondrial genome maintenance molecular_function mitochondrion
YFL042C_p YFL042C hom 0.0250113288465967 0.147504669226963 742 Putative protein of unknown function; YFL042C is not an essential gene biological_process molecular_function cellular_component
YER019W ISC1 hom FT LIPID METABOLISM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.0250080669836645 0.147557490285891 743 Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance response to salt stress|ceramide biosynthetic process|sphingolipid catabolic process inositol phosphosphingolipid phospholipase activity mitochondrion|endoplasmic reticulum|integral to mitochondrial outer membrane
YNL112W DBP2 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION 0.0249896240577145 0.148098386409186 744 ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|rRNA processing RNA helicase activity mitochondrion|nucleus|cytoplasm
YLR407W_p YLR407W hom 0.0249589335857437 0.148294379000651 745 Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus biological_process molecular_function cellular_component
YDR456W NHX1 hom FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS|GOLGI APPARATUS 0.0248427897425376 0.150192062231654 746 Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion sodium ion transmembrane transport|potassium ion transmembrane transport|cellular monovalent inorganic cation homeostasis|vacuolar acidification sodium:hydrogen antiporter activity|potassium:hydrogen antiporter activity trans-Golgi network|late endosome|fungal-type vacuole membrane|integral to membrane|early endosome
YGR087C PDC6 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0248136028674688 0.150671846682878 747 Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation L-phenylalanine catabolic process|ethanol metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway pyruvate decarboxylase activity cytoplasm
YJR039W_p YJR039W hom FT MITOCHONDRION 0.0248054024505105 0.150806858031449 748 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YER024W YAT2 hom FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM 0.0248003897473336 0.150889432359406 749 Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane carnitine metabolic process|alcohol metabolic process carnitine O-acetyltransferase activity cytosol|cytoplasm
YFR022W ROG3 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION 0.0247893176385815 0.151376968015084 750 Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; ROG3 has a paralog, ROD1, that arose from the whole genome duplication ubiquitin-dependent endocytosis ubiquitin protein ligase binding cellular_component
YGL093W SPC105 het FF|FT PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.0247651394327022 0.151593135856696 751 Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components microtubule nucleation|protein localization to kinetochore|sister chromatid biorientation|mitotic cell cycle spindle assembly checkpoint microtubule binding|structural constituent of cytoskeleton mitochondrion|condensed nuclear chromosome kinetochore|spindle pole body
YGR280C PXR1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0247444707196524 0.151812923851344 752 Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain box C/D snoRNA 3'-end processing|negative regulation of telomere maintenance via telomerase telomerase inhibitor activity nucleoplasm|nucleolus
YLR095C IOC2 hom FT CHROMATIN ORGANIZATION|NUCLEUS 0.0247034372844662 0.152493314927007 753 Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif chromatin remodeling protein binding|nucleosome binding|ATPase activity|DNA binding ISW1 complex
YMR105C PGM2 hom FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.0246999402412454 0.152857592510095 754 Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress glucose 6-phosphate metabolic process|cellular calcium ion homeostasis|galactose catabolic process|cellular cation homeostasis|glucose 1-phosphate metabolic process|trehalose biosynthetic process|UDP-glucose metabolic process|glycogen biosynthetic process phosphoglucomutase activity cytoplasm
YGL152C_d YGL152C hom 0.0246551526282668 0.15329690916512 755 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W Unknown Unknown Unknown
YGL194C HOS2 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|NUCLEUS|CHROMOSOME 0.0246377956583103 0.153586563839048 756 Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS negative regulation of meiosis|chromatin organization|regulation of transcription, DNA-dependent|positive regulation of stress-activated MAPK cascade|histone deacetylation NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity Rpd3L-Expanded complex|Set3 complex
YKL021C MAK11 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|ENDOMEMBRANE SYSTEM|NUCLEUS 0.0245873106486101 0.154431426609985 757 Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats ribosomal large subunit assembly|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function membrane
YOR252W TMA16 hom FT NUCLEUS 0.0245842198260359 0.154483265716964 758 Protein of unknown function that associates with ribosomes biological_process molecular_function ribosome|nucleus
YMR163C INP2 hom FT PEROXISOME ORGANIZATION 0.0245098403316013 0.15579641391397 759 Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene peroxisome inheritance protein anchor peroxisome|integral to peroxisomal membrane|cytoplasm
YPL071C_p YPL071C hom FT NUCLEUS 0.0244942726471509 0.155997649205402 760 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YMR317W_p YMR317W hom 0.0244562283638548 0.156703361423054 761 Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene biological_process molecular_function cellular_component
YPL056C_p LCL1 hom FT PLASMA MEMBRANE 0.0244453767943944 0.156887422162155 762 Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan biological_process molecular_function cellular_component
YGR031W IMO32 hom FT MITOCHONDRION 0.0244446631588711 0.156837695787206 763 Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 biological_process molecular_function mitochondrion
YIL003W CFD1 het FT RNA PROCESSING|COFACTOR METABOLISM 0.0243915379852893 0.157741070564553 764 Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol iron-sulfur cluster assembly|tRNA wobble uridine modification 4 iron, 4 sulfur cluster binding|ATPase activity cytoplasm
YMR153W NUP53 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0243781777239791 0.157968875936641 765 FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication positive regulation of transcription, DNA-dependent|NLS-bearing substrate import into nucleus|regulation of protein desumoylation|nuclear pore organization|protein import into nucleus|regulation of mitosis|mitotic cell cycle spindle assembly checkpoint nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YEL072W RMD6 hom FT CELL CYCLE 0.0243698554726581 0.158110904213935 766 Protein required for sporulation biological_process molecular_function cellular_component
YJL165C HAL5 hom FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS 0.0243483048509127 0.159101189716184 767 Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication cellular cation homeostasis|protein phosphorylation|cellular protein localization|protein dephosphorylation protein kinase activity cellular_component
YDL199C_p YDL199C hom 0.0243114392952964 0.159297164414452 768 Putative transporter, member of the sugar porter family transport|transmembrane transport substrate-specific transmembrane transporter activity integral to membrane|membrane
YDL156W CMR1 hom FT NUCLEUS|CHROMOSOME 0.024287446172964 0.159522530605926 769 DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS biological_process DNA binding nuclear chromatin|nucleus|cytoplasm
YKR042W UTH1 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|GENE SILENCING|MITOCHONDRION 0.0242398011475434 0.160342999567388 770 Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication mitochondrion degradation|fungal-type cell wall biogenesis|negative regulation of chromatin silencing involved in replicative cell aging molecular_function mitochondrial outer membrane|fungal-type cell wall
YDL009C_p YDL009C hom 0.0242237177309453 0.160620681877037 771 Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene biological_process molecular_function cellular_component
YOR292C_p YOR292C hom 0.0242028024407099 0.16098233024997 772 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene biological_process molecular_function integral to membrane|fungal-type vacuole
YBR058C UBP14 hom FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS 0.0241440684193308 0.162001193649796 773 Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T protein deubiquitination|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process ubiquitin-specific protease activity cytoplasm
YNR032W PPG1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS 0.0241131763987516 0.162539028387956 774 Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases glycogen metabolic process|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YML124C TUB3 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION|NUCLEUS|CYTOSKELETON 0.0241114587747069 0.162631643420789 775 Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation structural constituent of cytoskeleton tubulin complex|cytoplasmic microtubule|kinetochore microtubule|nuclear microtubule|spindle pole body|polar microtubule
YJR129C_p YJR129C hom 0.0241059096091268 0.162665739693423 776 Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process S-adenosylmethionine-dependent methyltransferase activity cytoplasm
YDR104C SPO71 hom FT CELL WALL ORG/BIOGENESIS 0.0240844984568914 0.163039519854332 777 Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains ascospore wall assembly molecular_function ascospore wall
YLR425W TUS1 hom FT SIGNALING|CELL WALL ORG/BIOGENESIS|SITE OF POLARIZED GROWTH 0.0240586801568047 0.163491097323236 778 Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate fungal-type cell wall organization|signal transduction Rho guanyl-nucleotide exchange factor activity incipient cellular bud site|cellular bud neck
YHR204W MNL1 hom FT PROTEOLYSIS|ENDOPLASMIC RETICULUM 0.0240144896780192 0.16426620110175 779 Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation ER-associated protein catabolic process carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity endoplasmic reticulum lumen
YLR233C EST1 hom FT NUCLEUS|CHROMOSOME 0.0239439365398887 0.165509438114193 780 TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA telomere maintenance via telomerase|telomere maintenance|G-quadruplex DNA formation single-stranded DNA binding|RNA binding|telomeric DNA binding nucleolus|nucleus|telomerase holoenzyme complex
YBR277C_d YBR277C hom 0.0239314162352597 0.165730799443556 781 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W Unknown Unknown Unknown
YBR198C TAF5 het FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE 0.0239254513397701 0.166342124687989 782 Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter ubiquitin binding|chromatin binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YMR107W SPG4 hom 0.0239050531377341 0.166197631779075 783 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources biological_process molecular_function cellular_component
YLR072W_p YLR072W hom FT ENDOMEMBRANE SYSTEM 0.0238925830190032 0.166482000804184 784 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene biological_process molecular_function cytoplasm
YGL012W ERG4 hom FF|FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOPLASMIC RETICULUM 0.0238610110120559 0.16697972470107 785 C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol ergosterol biosynthetic process delta24(24-1) sterol reductase activity integral to membrane|endoplasmic reticulum
YOR208W PTP2 hom FT PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION|NUCLEUS 0.023845356635612 0.167258377535498 786 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus inactivation of MAPK activity involved in osmosensory signaling pathway|inactivation of MAPK activity involved in cell wall biogenesis|regulation of sporulation|regulation of protein localization|protein dephosphorylation protein tyrosine phosphatase activity nucleus
YKL057C NUP120 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0238381323653795 0.167387089529497 787 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160 double-strand break repair|protein export from nucleus|ribosomal large subunit export from nucleus|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore outer ring
YHR021W-A_p ECM12 hom FT CELL WALL ORG/BIOGENESIS 0.0238142153632319 0.167813740127534 788 Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity fungal-type cell wall organization molecular_function cellular_component
YJL141C YAK1 hom FT PROTEIN PHOSPHORYLATION|NUCLEUS 0.0237642195102546 0.168708242036822 789 Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose protein phosphorylation protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity nucleus|cytoplasm
YGL201C MCM6 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.023755617962862 0.168926032687375 790 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|DNA unwinding involved in replication|double-strand break repair via break-induced replication|pre-replicative complex assembly|DNA replication initiation four-way junction helicase activity|DNA helicase activity|DNA replication origin binding|single-stranded DNA-dependent ATPase activity|ATP-dependent 3'-5' DNA helicase activity replication fork protection complex|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YIL165C_p YIL165C hom 0.02372528517181 0.169407309917493 791 Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene mitochondrion degradation molecular_function cellular_component
YML005W TRM12 hom FT RNA PROCESSING 0.0237146233609832 0.169599121427606 792 S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA wybutosine biosynthetic process|tRNA methylation S-adenosylmethionine-dependent methyltransferase activity|transferase activity, transferring alkyl or aryl (other than methyl) groups cytoplasm
YOR063W RPL3 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0237127160272784 0.16963345250808 793 Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YHL022C SPO11 hom FT CELL CYCLE|NUCLEUS|CHROMOSOME 0.0236387133209628 0.170969489940451 794 Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation meiotic DNA double-strand break formation endodeoxyribonuclease activity, producing 3'-phosphomonoesters nuclear chromosome
YLR336C SGD1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.0236326624180905 0.171079079728386 795 Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia ribosomal small subunit biogenesis|hyperosmotic response molecular_function nucleolus|nucleus|FAl1-SGD1 complex
YLL035W GRC3 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|CHROMOSOME 0.0236085836307158 0.171515699117039 796 Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated termination of RNA polymerase I transcription|rRNA processing polynucleotide 5'-hydroxyl-kinase activity nucleolar chromatin
YDL243C AAD4 hom FT OXIDATION-REDUCTION PROCESS 0.0235908390959565 0.17209386225609 797 Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YMR021C MAC1 hom FF|FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS|NUCLEUS 0.02358577600477 0.171930037004739 798 Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport cellular copper ion homeostasis|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter core promoter proximal region DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YEL035C_p UTR5 het 0.0235697682635969 0.17273386227214 799 Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions biological_process molecular_function cellular_component
YNL114C_d YNL114C het 0.0235549031676717 0.172492084641691 800 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit Unknown Unknown Unknown
YPR032W SRO7 hom FT VESICLE-MEDIATED TRANSPORT|SIGNALING|PLASMA MEMBRANE 0.0234820882355806 0.17382313715089 801 Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication establishment of cell polarity|exocytosis|Golgi to plasma membrane transport|small GTPase mediated signal transduction SNARE binding|Rab GTPase binding cytosol|plasma membrane
YDR280W RRP45 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0234541668707109 0.174785855472155 802 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nonfunctional rRNA decay|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|U1 snRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YBR087W RFC5 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0234245660752766 0.174880049926065 803 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon mismatch repair|sister chromatid cohesion|leading strand elongation DNA clamp loader activity Elg1 RFC-like complex|Rad17 RFC-like complex|DNA replication factor C complex|Ctf18 RFC-like complex
YKR041W YKR041W hom FT NUCLEUS|CYTOSKELETON 0.0234120460662451 0.175175069029129 804 Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking biological_process molecular_function nucleus|mitotic spindle|cytoplasm
YLL041C SDH2 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.0234015148861599 0.175627041043862 805 Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II|mitochondrion|mitochondrial membrane
YBR288C APM3 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.023384304290785 0.175622667721947 806 Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway Golgi to vacuole transport|vesicle-mediated transport molecular_function AP-3 adaptor complex
YDL010W GRX6 hom FT RESPONSE TO OXIDATIVE STRESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.023370929806348 0.175869875999949 807 Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication cellular response to oxidative stress glutathione-disulfide reductase activity|iron ion binding|protein homodimerization activity|2 iron, 2 sulfur cluster binding integral to membrane|Golgi apparatus|Golgi lumen|endoplasmic reticulum membrane|fungal-type vacuole|cis-Golgi network
YDL171C GLT1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.0233063796110592 0.177066642180442 808 NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source glutamate biosynthetic process|ammonia assimilation cycle glutamate synthase (NADH) activity mitochondrion
YBR278W DPB3 hom FT RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0233025727810338 0.177137410035743 809 Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication DNA-dependent DNA replication|chromatin silencing at telomere double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity epsilon DNA polymerase complex
YBR006W UGA2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS 0.0232980925014261 0.177285327392758 810 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm cellular response to oxidative stress|gamma-aminobutyric acid catabolic process|glutamate decarboxylation to succinate succinate-semialdehyde dehydrogenase [NAD(P)+] activity cytoplasm
YPL044C_d YPL044C het 0.0232906426337055 0.177423944638302 811 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W Unknown Unknown Unknown
YPL084W BRO1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.0232866606792064 0.177433439342733 812 Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes protein deubiquitination|vacuolar transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|response to nutrient|ubiquitin-dependent protein catabolic process ubiquitin-specific protease activity endosome|cytoplasm
YDR528W HLR1 hom FT CELL WALL ORG/BIOGENESIS 0.0232835177442405 0.177491954144896 813 Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cytoplasm
YJL217W REE1 hom 0.0232598780727409 0.177932535238409 814 Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle biological_process molecular_function cytoplasm
YGL210W YPT32 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS 0.0232329491774018 0.178629744112045 815 Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication early endosome to Golgi transport|vesicle-mediated transport|exocytosis GTPase activity endosome|mitochondrial outer membrane|Golgi apparatus
YJL196C ELO1 hom FT KETONE METABOLISM|LIPID METABOLISM 0.0232300482634652 0.1784896447822 816 Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication fatty acid elongation, unsaturated fatty acid fatty acid elongase activity integral to membrane|membrane
YDL130W-A STF1 hom FT NUCLEOTIDE METABOLISM|MITOCHONDRION 0.0232224043825614 0.178632612542986 817 Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress negative regulation of ATPase activity molecular_function mitochondrion|mitochondrial proton-transporting ATP synthase complex
YFR003C YPI1 het FT CELL CYCLE|LIPID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS 0.0231765404968831 0.17949221908082 818 Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance negative regulation of phosphoprotein phosphatase activity|glycogen metabolic process|cellular ion homeostasis|Unknown|positive regulation of phosphoprotein phosphatase activity|negative regulation of protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint protein serine/threonine phosphatase inhibitor activity|protein phosphatase type 1 activator activity nucleus
YML114C TAF8 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0231385321464308 0.180206918832731 819 TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly nucleus|transcription factor TFIID complex
YMR173W DDR48 hom FT RESPONSE TO DNA DAMAGE 0.0231267444380499 0.180429000793335 820 DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress DNA repair ATPase activity|GTPase activity cytoplasm
YDL089W NUR1 hom FT ENDOMEMBRANE SYSTEM|NUCLEUS 0.0231069344260965 0.181062978521224 821 Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate maintenance of rDNA molecular_function nuclear periphery
YDR360W_d OPI7 hom 0.023083002657626 0.181254877790111 822 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C. Unknown Unknown Unknown
YMR078C CTF18 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CHROMOSOME 0.0230455025601987 0.181965137367306 823 Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint maintenance of DNA trinucleotide repeats|double-strand break repair via homologous recombination|DNA replication initiation|mitotic sister chromatid cohesion molecular_function mitochondrion|nuclear replication fork|Ctf18 RFC-like complex
YDL114W_p YDL114W hom FT OXIDATION-REDUCTION PROCESS 0.0230357725300213 0.182410690544343 824 Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene biological_process molecular_function integral to membrane
YGL007W_d BRP1 hom FF 0.0230305624334352 0.182248680582627 825 Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Unknown Unknown Unknown
YBR041W FAT1 hom FT KETONE METABOLISM|LIPID METABOLISM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.0230201114172922 0.182447221205453 826 Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids very long-chain fatty acid metabolic process|long-chain fatty acid transport very long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity intrinsic to internal side of plasma membrane|integral to membrane|endoplasmic reticulum|lipid particle|peroxisome
YFL036W RPO41 hom FT MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0230195421173531 0.182719111696167 827 Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation transcription from mitochondrial promoter|mitochondrial genome maintenance DNA-directed RNA polymerase activity mitochondrial nucleoid|mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix
YMR251W-A HOR7 hom FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.0229644443729595 0.183703569141299 828 Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication plasma membrane organization molecular_function endoplasmic reticulum|plasma membrane
YLR036C_p YLR036C hom 0.0229360313677976 0.184050347221771 829 Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein biological_process molecular_function integral to membrane
YLR278C_p YLR278C hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0229112326156194 0.184525161810006 830 Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene biological_process sequence-specific DNA binding nucleus
YDR200C VPS64 hom FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0228737542236869 0.185244468634343 831 Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole molecular_function endoplasmic reticulum membrane|cytoplasm
YOR234C RPL33B hom FT TRANSLATION|RIBOSOME 0.0228693429119013 0.185329269243927 832 Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGL181W GTS1 hom FT VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM|NUCLEUS|CYTOSKELETON 0.0228615895863153 0.185478384416551 833 Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations endocytosis|ultradian rhythm|regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylinositol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter ARF GTPase activator activity|repressing transcription factor binding|transcription factor binding transcription factor activity nucleus|cytoplasm|actin cortical patch
YGL171W ROK1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION|NUCLEUS 0.0228291234673587 0.186103749562534 834 RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|snoRNA localization RNA-dependent ATPase activity nucleolus|90S preribosome
YJL172W CPS1 hom FT PROTEOLYSIS 0.0228187280921318 0.186567132726761 835 Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions nitrogen compound metabolic process|proteolysis involved in cellular protein catabolic process carboxypeptidase activity fungal-type vacuole lumen
YLR232W_d YLR232W hom 0.0227748830890791 0.187152005385946 836 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5 Unknown Unknown Unknown
YML097C VPS9 hom FF|FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT 0.0227689604022981 0.187266731319118 837 A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin vacuole inheritance|protein targeting to vacuole ubiquitin binding|guanyl-nucleotide exchange factor activity cytosol
YDL055C PSA1 het FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 0.0225678965868476 0.191192306792845 838 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure protein glycosylation|cell wall mannoprotein biosynthetic process|GDP-mannose biosynthetic process mannose-1-phosphate guanylyltransferase activity cytoplasm
YAL019W FUN30 hom FT CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|MITOCHONDRION|CHROMOSOME 0.0225330011421504 0.191879725859546 839 Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate chromosome organization|chromatin silencing at rDNA|heterochromatin maintenance involved in chromatin silencing|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|heterochromatin assembly involved in chromatin silencing chromatin binding|DNA-dependent ATPase activity|DNA binding|protein homodimerization activity mitochondrion|mating-type region heterochromatin|nucleus
YKR040C_d YKR040C hom 0.0225105755583555 0.19232245418513 840 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W Unknown Unknown Unknown
YOR203W_d YOR203W het 0.0224965187164405 0.192600348345122 841 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation Unknown Unknown Unknown
YIL052C RPL34B hom FF|FT TRANSLATION|RIBOSOME 0.0224958820995 0.192612940805733 842 Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR256C CTA1 hom FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION 0.02249124998435 0.192704583546496 843 Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation response to reactive oxygen species|age-dependent response to reactive oxygen species|hydrogen peroxide catabolic process catalase activity peroxisomal matrix|mitochondrial matrix
YDR018C_p YDR018C hom FT LIPID METABOLISM 0.0224757523184777 0.193011425468044 844 Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication phospholipid biosynthetic process transferase activity, transferring acyl groups integral to membrane
YGR024C THG1 het FT RNA PROCESSING|NUCLEUS 0.0224739443724987 0.193047244771745 845 tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes tRNA modification tRNA guanylyltransferase activity nucleus|cytoplasm
YML087C AIM33 hom FT OXIDATION-REDUCTION PROCESS 0.0224402330927708 0.193716032193988 846 Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication biological_process molecular_function cellular_component
YER021W RPN3 het FT PROTEOLYSIS 0.0224221284471126 0.194075905616851 847 Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control ubiquitin-dependent protein catabolic process molecular_function proteasome regulatory particle, lid subcomplex
YFL002C SPB4 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0224075271159776 0.19436649936061 848 Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients ribosomal large subunit assembly|rRNA processing ATP-dependent RNA helicase activity nucleolus|90S preribosome
YLR213C CRR1 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 0.0224016899149426 0.194482759811919 849 Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation ascospore wall assembly hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ascospore wall
YPR038W_d IRC16 hom 0.022362916997022 0.195256300916249 850 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YGR179C OKP1 het FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE 0.0223523983630291 0.19546654180963 851 Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7 attachment of spindle microtubules to kinetochore|chromosome segregation molecular_function COMA complex|condensed nuclear chromosome kinetochore
YGR245C SDA1 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CYTOSKELETON ORGANIZATION|NUCLEUS 0.0223141342911956 0.196232743178274 852 Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis ribosomal large subunit biogenesis|ribosomal large subunit export from nucleus|traversing start control point of mitotic cell cycle|actin cytoskeleton organization molecular_function nucleus
YDR263C DIN7 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION 0.0222771463729305 0.197376592813524 853 Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination DNA repair nuclease activity mitochondrion
YML081C-A ATP18 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION 0.0222341257112526 0.197841941373879 854 Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YDR099W BMH2 hom FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS 0.0222144499536963 0.198239150622966 855 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress glycogen metabolic process|ascospore formation|Ras protein signal transduction|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|DNA damage checkpoint|DNA replication initiation|signal transduction involved in filamentous growth|pseudohyphal growth|fungal-type cell wall chitin biosynthetic process|pre-replicative complex assembly DNA replication origin binding|phosphoserine binding nucleus|plasma membrane
YLR318W EST2 hom FT NUCLEUS|CHROMOSOME 0.0222080927099009 0.198836629549133 856 Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia telomere maintenance via telomerase|replicative cell aging telomerase activity|telomeric template RNA reverse transcriptase activity|telomeric DNA binding telomerase catalytic core complex|nucleolus|nucleus|telomerase holoenzyme complex
YJR065C ARP3 het FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.0221874845449929 0.198784468054501 857 Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity mitochondrion inheritance|Arp2/3 complex-mediated actin nucleation|actin filament organization ATP binding Arp2/3 protein complex|plasma membrane
YCR095W-A_p YCR095W-A hom 0.022093778177073 0.200687999720844 858 Putative protein of unknown function biological_process molecular_function cellular_component
YLR450W HMG2 hom FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.022068377785552 0.201340678046 859 HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at the nuclear periphery upon DNA replication stress ergosterol biosynthetic process hydroxymethylglutaryl-CoA reductase (NADPH) activity nuclear envelope|integral to membrane|endoplasmic reticulum membrane
YDR258C HSP78 hom FT PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0220526226918786 0.201528213094657 860 Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates positive regulation of mitochondrial translation in response to stress|protein refolding|protein stabilization|protein import into mitochondrial matrix|mitochondrial genome maintenance|protein unfolding|cellular response to heat misfolded protein binding|ATPase activity mitochondrion|mitochondrial matrix
YMR088C VBA1 hom 0.0220499932444943 0.204018999837719 861 Permease of basic amino acids in the vacuolar membrane basic amino acid transport basic amino acid transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YGL087C MMS2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|NUCLEUS 0.0220377579569944 0.201832314828111 862 Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress postreplication repair|response to DNA damage stimulus|protein polyubiquitination|free ubiquitin chain polymerization ubiquitin-protein ligase activity ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YMR102C_p YMR102C hom 0.0220275280988738 0.202041790739072 863 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene biological_process molecular_function cellular_component
YML104C MDM1 hom FT MITOCHONDRION ORGANIZATION|CYTOSKELETON 0.0220164740141717 0.202470286140657 864 Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) nuclear migration|mitochondrion inheritance|mitochondrion organization structural constituent of cytoskeleton|phosphatidylinositol-3-phosphate binding intermediate filament|integral to membrane|cytoplasm
YAL053W FLC2 hom FT CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0219662004037555 0.203300914604214 865 Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication protein folding|fungal-type cell wall biogenesis|FAD transport|transmembrane transport FAD transmembrane transporter activity integral to membrane|endoplasmic reticulum|cytoplasm
YKR033C_d YKR033C hom 0.0219619118073868 0.2033891772929 866 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80 Unknown Unknown Unknown
YOL091W SPO21 hom FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON 0.0219563145727496 0.203706722003964 867 Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation ascospore wall assembly|meiosis structural molecule activity spindle pole body
YKL101W HSL1 hom FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0219357442642127 0.203928330168996 868 Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p G2/M transition of mitotic cell cycle|regulation of cell cycle|cell shape checkpoint|protein autophosphorylation|protein phosphorylation|septin checkpoint protein kinase activity cellular bud neck|septin ring
YMR260C TIF11 het FT TRANSLATION|RIBOSOME 0.0219254531636816 0.204140651329837 869 Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 translational initiation double-stranded RNA binding|translation initiation factor activity ribosome
YDL094C_d YDL094C hom 0.0218650322530932 0.205390470693081 870 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential Unknown Unknown Unknown
YOL052C-A DDR2 hom 0.0218561007687781 0.205575690922457 871 Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication response to stress molecular_function fungal-type vacuole|cytoplasm
YDL085C-A_p YDL085C-A hom FT NUCLEUS 0.0218210940794331 0.206302825803634 872 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus biological_process molecular_function nucleus|cytoplasm
YJL129C TRK1 hom FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS 0.0217701560681812 0.207364207122547 873 Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication cellular potassium ion homeostasis potassium ion transmembrane transporter activity membrane raft|integral to membrane|plasma membrane
YBR254C TRS20 het FT VESICLE-MEDIATED TRANSPORT|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.0217622793519173 0.20752868498263 874 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder ER to Golgi vesicle-mediated transport molecular_function TRAPP complex
YHR073W OSH3 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOPLASMIC RETICULUM 0.0217266317376561 0.20827424447138 875 Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability karyogamy involved in conjugation with cellular fusion|endocytosis|exocytosis|positive regulation of phosphatase activity|maintenance of cell polarity|pseudohyphal growth|sterol transport|invasive growth in response to glucose limitation lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity cortical endoplasmic reticulum|cytoplasm
YLR316C TAD3 het FT RNA PROCESSING|NUCLEUS 0.0217196720050464 0.208420031434985 876 Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs tRNA modification tRNA-specific adenosine deaminase activity nucleus|cytoplasm
YOR354C MSC6 hom FT CELL CYCLE|MITOCHONDRION 0.0216691778514685 0.209547897814521 877 Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies reciprocal meiotic recombination molecular_function mitochondrion
YGL257C MNT2 hom FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.02166411063232 0.20958653893391 878 Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans protein O-linked glycosylation alpha-1,3-mannosyltransferase activity cellular_component
YLR241W_p YLR241W hom 0.0216478698190824 0.209996383218191 879 Putative protein of unknown function, may be involved in detoxification biological_process molecular_function integral to membrane
YMR184W ADD37 hom FT PROTEOLYSIS 0.0215585963388273 0.211814798792603 880 Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress ER-associated protein catabolic process molecular_function cytoplasm
YNL228W_d YNL228W hom 0.021536023138465 0.212293715661912 881 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Unknown Unknown Unknown
YDR508C GNP1 hom FT MITOCHONDRION|PLASMA MEMBRANE 0.0215349174912811 0.212317193331705 882 High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication amino acid transport|transmembrane transport amino acid transmembrane transporter activity|L-proline transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YCR002C CDC10 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0215249953056701 0.212527968137384 883 Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress sporulation|maintenance of cell polarity|exit from mitosis|cell cycle cytokinesis|septin ring assembly protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding spindle microtubule|ascospore-type prospore|septin complex|prospore membrane|mating projection base|meiotic spindle|septin filament array|cellular bud neck septin ring|mating projection tip
YDR540C IRC4 hom FF|FT NUCLEUS 0.0214952431992358 0.213160891082138 884 Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus mitotic recombination molecular_function nucleus|cytoplasm
YPR007C REC8 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0214948912962328 0.213168385319563 885 Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p synaptonemal complex assembly|protein localization to chromosome, centromeric region|reciprocal meiotic recombination|meiotic sister chromatid cohesion molecular_function condensed nuclear chromosome|condensed nuclear chromosome, centromeric region
YGR103W NOP7 het FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0214739865305361 0.213613920951025 886 Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation ribosomal large subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cell cycle molecular_function PeBoW complex|nucleolus|nucleus|preribosome, large subunit precursor
YGR261C APL6 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0214679827317372 0.213742001775294 887 Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools vesicle-mediated transport|Golgi to vacuole transport molecular_function AP-3 adaptor complex
YLR259C HSP60 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0214633029049745 0.213841876313216 888 Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated protein refolding|protein stabilization|chaperone-mediated protein complex assembly|'de novo' protein folding|protein maturation|protein import into mitochondrial intermembrane space unfolded protein binding|DNA replication origin binding|single-stranded DNA binding|ATPase activity|chaperone binding mitochondrial nucleoid|mitochondrion
YOR251C TUM1 hom FT RNA PROCESSING|MITOCHONDRION 0.0214430114491479 0.214343655320653 889 Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized tRNA wobble position uridine thiolation|tRNA wobble uridine modification thiosulfate sulfurtransferase activity cytoplasm
YMR219W ESC1 hom FT GENE SILENCING|NUCLEUS 0.021427396433262 0.214609294181712 890 Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p chromatin silencing at telomere molecular_function nuclear periphery
YGL013C PDR1 hom FF|FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RSC COMPLEX 0.0214253911211951 0.214652211531693 891 Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Unknown|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YER188W_d YER188W hom 0.0214056981182898 0.21507400646641 892 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p Unknown Unknown Unknown
YLR050C_p YLR050C hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0214055913243284 0.215076295461209 893 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene biological_process molecular_function integral to membrane|endoplasmic reticulum
YNR066C_p YNR066C hom 0.0213931768833737 0.215342503050338 894 Putative membrane-localized protein of unknown function biological_process molecular_function integral to membrane|membrane
YOL159C-A YOL159C-A hom FT NUCLEUS 0.0213856203441743 0.215915674135473 895 Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species biological_process molecular_function nucleus|cytoplasm
YOR304C-A_p YOR304C-A hom FT SITE OF POLARIZED GROWTH 0.0213843800773713 0.215805196260048 896 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck biological_process molecular_function cellular bud|mating projection tip|cellular bud neck|cytoplasm
YBL023C MCM2 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0213762807844695 0.215705193658579 897 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|pre-replicative complex assembly|double-strand break repair via break-induced replication chromatin binding|DNA replication origin binding|DNA helicase activity|single-stranded DNA binding replication fork protection complex|nucleus|DNA replication preinitiation complex|pre-replicative complex|cytoplasm|MCM complex
YOR277C_d YOR277C hom 0.0213743874054527 0.21574586419999 898 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 Unknown Unknown Unknown
YGL209W MIG2 hom FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|MITOCHONDRION 0.0213368546702096 0.216553222041455 899 Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding mitochondrion|nucleus
YDR279W RNH202 hom FT NUCLEUS 0.0213263132437205 0.216780366629234 900 Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome RNA catabolic process|DNA replication, removal of RNA primer ribonuclease H activity ribonuclease H2 complex|nucleus
YGR270W YTA7 hom FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0213234821185475 0.216841400339451 901 Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter chromatin binding|histone binding extrinsic to endoplasmic reticulum membrane|nucleus
YIL097W FYV10 hom FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS 0.0213080371439182 0.217449016152866 902 Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis ubiquitin-protein ligase activity nucleus|GID complex|cytoplasm
YGR061C ADE6 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM 0.0213041955861025 0.217257510422124 903 Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway 'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process phosphoribosylformylglycinamidine synthase activity cytoplasm
YBL092W RPL32 het FF|FT TRANSLATION|RIBOSOME 0.0212961487242628 0.217911962315552 904 Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YLR113W HOG1 hom FT TRANSCRIPTION FROM RNA POL II|SIGNALING|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0212961279281173 0.217431741643776 905 Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress negative regulation of transcription from RNA polymerase II promoter by pheromones|protein phosphorylation|hyperosmotic response|response to arsenic-containing substance|osmosensory signaling pathway|positive regulation of transcription from RNA polymerase II promoter|cellular response to heat MAP kinase activity nucleus|cytoplasm
YLL003W SFI1 het FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.0212887478461959 0.217591211738037 906 Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C G2/M transition of mitotic cell cycle|spindle assembly|spindle pole body duplication associated with nuclear envelope molecular_function half bridge of spindle pole body
YJL009W_d YJL009W het 0.0212841088170162 0.217691495705036 907 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex Unknown Unknown Unknown
YML094W GIM5 hom FT PROTEIN COMPLEX ORG/BIOGENESIS 0.0212733938066796 0.217923253824017 908 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YGR221C TOS2 hom FT CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0212688622367067 0.218021321810623 909 Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p budding cell bud growth molecular_function cellular bud neck|cellular bud tip
YCL036W GFD2 hom 0.0212569129406723 0.218280069290521 910 Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication biological_process molecular_function cellular_component
YGR158C MTR3 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0212363276820923 0.218726335196288 911 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YGL212W VAM7 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION 0.0212235877703458 0.219484365397507 912 Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle fusion SNAP receptor activity|phosphatidylinositol-3-phosphate binding SNARE complex|fungal-type vacuole membrane
YHR022C_p YHR022C hom FT SIGNALING 0.0211987046085898 0.219543654320012 913 Putative protein of unknown function; YHR022C is not an essential gene biological_process molecular_function cellular_component
YLR154C RNH203 hom FT NUCLEUS 0.0211910215088685 0.21998604142781 914 Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome RNA catabolic process|DNA replication, removal of RNA primer ribonuclease H activity ribonuclease H2 complex|nucleus|cytoplasm
YPL256C CLN2 hom FT CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0211607282060552 0.220370869006289 915 G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) regulation of cyclin-dependent protein kinase activity|re-entry into mitotic cell cycle after pheromone arrest cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YGL254W FZF1 hom FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS|NUCLEUS 0.0211501334486737 0.220602045717059 916 Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YNL146W_p YNL146W hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0211433325685945 0.220750531923485 917 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene biological_process molecular_function endoplasmic reticulum
YLR028C ADE16 hom FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.021134098795567 0.220952251043022 918 Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine ascospore formation|'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process|aerobic respiration phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity cytosol
YDR403W DIT1 hom FT CELL WALL ORG/BIOGENESIS 0.0211289870377769 0.221270651641627 919 Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure ascospore wall assembly catalytic activity cellular_component
YDL142C CRD1 hom FT LIPID METABOLISM|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION 0.0210933902054465 0.221843137382088 920 Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis lipid biosynthetic process|cellular ion homeostasis|mitochondrial membrane organization cardiolipin synthase activity mitochondrion|integral to membrane
YDR341C YDR341C het FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION 0.0210860265756746 0.222004560907452 921 Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies cytoplasmic translation|arginyl-tRNA aminoacylation arginine-tRNA ligase activity mitochondrion|cytoplasm
YBL009W ALK2 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION 0.0210445360412223 0.222915677187681 922 Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins meiosis|mitosis|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity cellular_component
YER116C SLX8 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0209767673990136 0.224409597658574 923 Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination ubiquitin-protein ligase activity ubiquitin ligase complex|nucleus
YJR059W PTK2 hom FF|FT CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|NUCLEUS|PLASMA MEMBRANE 0.0209702714982047 0.224553170793757 924 Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake protein phosphorylation|cellular ion homeostasis|polyamine transport|G1/S transition of mitotic cell cycle|regulation of cell size protein kinase activity nucleus|plasma membrane|cytoplasm
YIL066C RNR3 hom FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|MITOCHONDRION 0.0209643558746403 0.224683975647943 925 Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits deoxyribonucleotide biosynthetic process ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor mitochondrion|ribonucleoside-diphosphate reductase complex|cytoplasm
YML066C SMA2 hom FT MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|ENDOPLASMIC RETICULUM 0.0208979448149947 0.226156177029105 926 Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation ascospore wall assembly|spore membrane bending pathway molecular_function integral to membrane|prospore membrane|cytoplasm
YMR085W_p YMR085W hom FT CARBOHYDRATE METABOLISM 0.0208943067840047 0.226444808340081 927 Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 biological_process molecular_function cellular_component
YMR201C RAD14 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.0208900136699497 0.226332453641583 928 Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein nucleotide-excision repair, DNA damage recognition damaged DNA binding|zinc ion binding nucleotide-excision repair factor 1 complex|nucleus
YLR169W_d YLR169W hom 0.020845420646072 0.227325396891537 929 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL294C RIM21 hom FF|FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0208412792851581 0.227417768956717 930 pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH fungal-type cell wall biogenesis|ascospore formation|invasive growth in response to glucose limitation molecular_function integral to membrane
YGR173W RBG2 hom FT TRANSLATION 0.0208319421985481 0.227626128551926 931 Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein cytoplasmic translation GTP binding cytoplasm
YDR531W CAB1 het FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.0208271540689694 0.22773302968237 932 Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element coenzyme A biosynthetic process pantothenate kinase activity nucleus|cytoplasm
YGR266W YGR266W hom FT MITOCHONDRION|PLASMA MEMBRANE 0.0208134821589124 0.228038469420439 933 Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrial outer membrane|mitochondrion|plasma membrane
YER145C FTR1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0208118453687131 0.228075055966553 934 High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress iron assimilation by reduction and transport|high-affinity iron ion transport|transmembrane transport iron ion transmembrane transporter activity high affinity iron permease complex|integral to membrane|plasma membrane
YHL003C LAG1 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0207966942357577 0.22869161286575 935 Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress replicative cell aging|ceramide biosynthetic process sphingosine N-acyltransferase activity integral to membrane|endoplasmic reticulum
YBR015C MNN2 hom FF|FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0207864887000219 0.228642377908281 936 Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment protein glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YKL063C_p YKL063C hom FT GOLGI APPARATUS 0.0207679385842949 0.229058047879748 937 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi biological_process molecular_function Golgi apparatus
YPR171W BSP1 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON 0.0207595195770027 0.229663899922822 938 Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton actin cortical patch localization protein binding, bridging mating projection tip|membrane|cellular bud neck|actin cortical patch|cellular bud tip
YBR176W ECM31 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|MITOCHONDRION 0.0207272412197985 0.229971875146049 939 Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate pantothenate biosynthetic process 3-methyl-2-oxobutanoate hydroxymethyltransferase activity mitochondrion
YML009W-B_d YML009W-B hom 0.0207192198639524 0.230152293695475 940 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Unknown Unknown Unknown
YGR035C_p YGR035C hom 0.0206968091126415 0.23065689561376 941 Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance biological_process molecular_function cellular_component
YGR098C ESP1 het FT CELL CYCLE|LIPID METABOLISM|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CYTOSKELETON 0.0206673442496225 0.231321523681363 942 Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress regulation of exit from mitosis|regulation of mitotic spindle elongation|negative regulation of protein phosphatase type 2A activity|apoptotic process|mitotic sister chromatid segregation cysteine-type endopeptidase activity mitochondrion|nucleus|cytoplasm|spindle
YFR040W SAP155 hom FT CELL CYCLE 0.0206595940675518 0.231496567330626 943 Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity cytoplasm
YLR394W CST9 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0206476988141269 0.231765413397471 944 SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate synaptonemal complex assembly|protein sumoylation|synapsis|reciprocal meiotic recombination SUMO ligase activity condensed nuclear chromosome|nuclear chromosome
YMR215W GAS3 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 0.0206471918846243 0.23177687549368 945 Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation biological_process 1,3-beta-glucanosyltransferase activity fungal-type cell wall|integral to membrane|plasma membrane
YMR012W CLU1 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION 0.0206010907018015 0.232820943944874 946 eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant translational initiation|mitochondrion organization molecular_function eukaryotic translation initiation factor 3 complex|cytoplasm
YER109C FLO8 hom FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|NUCLEUS 0.0205954835863519 0.232948157218625 947 Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene biofilm formation|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YNL212W VID27 hom 0.0205808741565729 0.233279844915102 948 Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth biological_process molecular_function cytoplasm
YAL049C AIM2 hom 0.0205745168429151 0.233424283753014 949 Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor biological_process molecular_function cytoplasm
YOR004W UTP23 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION 0.0205444037535896 0.234109317434154 950 Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|mitochondrion|nucleolus
YIL136W OM45 hom FT MITOCHONDRION 0.0205384260453052 0.23424547174288 951 Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YHR195W NVJ1 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS 0.0205173795799826 0.234725293507405 952 Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) microautophagy|cellular protein localization protein binding nuclear envelope
YLR027C AAT2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0204852982443601 0.23545802840486 953 Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells aspartate biosynthetic process L-aspartate:2-oxoglutarate aminotransferase activity cytosol|peroxisome
YHR009C_p TDA3 hom FT VESICLE-MEDIATED TRANSPORT|OXIDATION-REDUCTION PROCESS 0.0204842909747991 0.23548106052363 954 Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1 retrograde transport, endosome to Golgi molecular_function late endosome|cytoplasm
YCL010C SGF29 hom FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.0204611833713412 0.236009874236534 955 Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation histone H3-K14 acetylation|cellular protein complex localization|histone H3-K18 acetylation|cellular protein localization|histone H3-K9 acetylation|positive regulation of transcription from RNA polymerase II promoter methylated histone residue binding|RNA polymerase II transcription factor recruiting transcription factor activity Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YLR017W MEU1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.0204587445375415 0.236065735495501 956 Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression L-methionine salvage from methylthioadenosine|glutamate biosynthetic process S-methyl-5-thioadenosine phosphorylase activity|mRNA binding cytoplasm
YDR189W SLY1 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.0204496733002596 0.236273593379945 957 Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|positive regulation of SNARE complex assembly SNARE binding|syntaxin binding SNARE complex|endoplasmic reticulum|ER to Golgi transport vesicle|Golgi membrane
YDL221W_d YDL221W het 0.0203734002890582 0.238096415757113 958 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13 Unknown Unknown Unknown
YDR071C PAA1 hom FT CHROMATIN ORGANIZATION 0.020353884934254 0.23847638175051 959 Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication chromatin organization diamine N-acetyltransferase activity|aralkylamine N-acetyltransferase activity cytoplasm
YNL141W AAH1 hom FT NUCLEOTIDE METABOLISM|NUCLEUS 0.0203174373063643 0.239318339746249 960 Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome adenine catabolic process|hypoxanthine salvage|purine-containing compound salvage adenine deaminase activity nucleus|cytoplasm
YOR333C_d YOR333C hom 0.0202992566298159 0.239739104706262 961 Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth Unknown Unknown Unknown
YDR101C ARX1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS|NUCLEUS|RIBOSOME 0.0202768245528527 0.240329096682593 962 Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex ribosomal large subunit biogenesis molecular_function nucleoplasm|cytosolic large ribosomal subunit|cytoplasm
YLR251W SYM1 hom FT MITOCHONDRION 0.020269958544635 0.240418262180356 963 Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17 ethanol metabolic process molecular_function mitochondrion|integral to membrane|mitochondrial inner membrane
YML031W NDC1 het FT PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON|NUCLEAR PORE 0.0202371531697972 0.241180328680198 964 Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1 nucleocytoplasmic transport|nuclear pore organization|spindle pole body duplication associated with nuclear envelope structural constituent of nuclear pore integral to membrane|nuclear pore transmembrane ring|spindle pole body|nuclear pore
YMR171C EAR1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT 0.020209922599895 0.24181418285053 965 Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway molecular_function endosome
YER014C-A BUD25 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION 0.0201839067033097 0.242420856348081 966 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern cellular bud site selection molecular_function cellular_component
YHL015W-A_p YHL015W-A hom 0.020167360031813 0.24315880630006 967 Putative protein of unknown function biological_process molecular_function cellular_component
YPL043W NOP4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0201578501200126 0.24302955035104 968 Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) rRNA processing RNA binding nucleolus
YDL231C BRE4 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION 0.0201419016267248 0.243402643995442 969 Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport endocytosis molecular_function integral to membrane
YOR160W MTR10 het FT PROTEIN LOCALIZATION|RNA LOCALIZATION|NUCLEUS 0.0201373879834525 0.243508307637184 970 Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress RNA localization|tRNA transport|RNA import into nucleus|protein import into nucleus|mRNA-binding (hnRNP) protein import into nucleus nuclear localization sequence binding integral to membrane|nucleus|cytoplasm
YGL157W ARI1 hom FT OXIDATION-REDUCTION PROCESS|NUCLEUS 0.0201295024389146 0.243692984224322 971 NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily biological_process oxidoreductase activity|carbonyl reductase (NADPH) activity nucleus|cytoplasm
YDR109C_p YDR109C hom FT CARBOHYDRATE METABOLISM 0.0201275958186891 0.244089437879311 972 Putative kinase biological_process molecular_function cellular_component
YGL109W_d YGL109W hom 0.020118316426276 0.243955125249085 973 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Unknown Unknown Unknown
YDR340W_d YDR340W hom 0.0200905056574012 0.24460772043546 974 Putative protein of unknown function Unknown Unknown Unknown
YBL097W BRN1 het FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0200565858713 0.245405323825372 975 Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission mitotic chromosome condensation|tRNA gene clustering|mitotic sister chromatid segregation molecular_function nucleus|SMC loading complex|nuclear condensin complex
YER112W LSM4 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0200511361709479 0.245604042564463 976 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|cytoplasmic mRNA processing body assembly U6 snRNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|cytoplasmic mRNA processing body|U4/U6 x U5 tri-snRNP complex
YNL180C RHO5 hom FT SIGNALING|NUCLEUS|PLASMA MEMBRANE 0.0200368997442782 0.246080400169344 977 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity Rho protein signal transduction GTPase activity endomembrane system|fungal-type vacuole membrane|plasma membrane|nucleus|cytoplasm
YHL015W RPS20 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.020033809425331 0.245941920494031 978 Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10 cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YLR222C UTP13 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0200280620203334 0.246077455038428 979 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) snoRNA binding small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YPL008W CHL1 hom FT CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS 0.0200177655051184 0.246390840036703 980 Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome negative regulation of DNA recombination|chromosome segregation|donor selection|DNA replication initiation|mitotic sister chromatid cohesion DNA helicase activity nucleus
YJL204C RCY1 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH 0.0199930032764185 0.246905338997328 981 F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth early endosome to Golgi transport|endocytosis SNARE binding endosome|Golgi apparatus|site of polarized growth
YIL079C AIR1 hom FT RNA PROCESSING|NUCLEUS 0.0199627794328606 0.247620614351402 982 Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent snRNA catabolic process polynucleotide adenylyltransferase activity nucleolus|TRAMP complex
YOL007C CSI2 hom FT SITE OF POLARIZED GROWTH 0.0199165588694762 0.24899967031613 983 Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene biological_process molecular_function fungal-type vacuole|cellular bud neck
YPR200C ARR2 hom 0.0199149439558424 0.248826211910433 984 Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p response to arsenic-containing substance arsenate reductase activity cellular_component
YMR086W SEG1 hom 0.0199081536327454 0.248917060373687 985 Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes biological_process molecular_function eisosome|ribosome|cytoplasm
YLR419W_p YLR419W hom FT MITOCHONDRION 0.0199023670304671 0.249054672436539 986 Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene biological_process molecular_function mitochondrion|cytoplasm
YDR152W GIR2 hom FT TRANSLATION 0.0198930812843064 0.249487455594697 987 Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein cytoplasmic translation molecular_function polysome|cytoplasm
YMR063W RIM9 hom FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0198563575011425 0.250929037940958 988 Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI; ascospore formation molecular_function integral to membrane
YBR196C-A_p YBR196C-A hom 0.0198414196655244 0.250648625411502 989 Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YIL083C CAB2 het FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.0198155765991629 0.251125028990642 990 Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity) coenzyme A biosynthetic process phosphopantothenate--cysteine ligase activity nucleus|cytoplasm
YGR051C_d YGR051C hom 0.0198128124217942 0.251403286052845 991 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene Unknown Unknown Unknown
YPR068C HOS1 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS 0.0197612060094647 0.252428120438158 992 Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex peptidyl-lysine deacetylation|histone H4 deacetylation|positive regulation of transcription from RNA polymerase II promoter histone deacetylase activity|protein deacetylase activity histone deacetylase complex
YLR296W_d YLR296W hom 0.0197556178716707 0.25256231694234 993 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR081W GAL2 hom FT CARBOHYDRATE METABOLISM|PLASMA MEMBRANE 0.0197404903366611 0.252925846921287 994 Galactose permease, required for utilization of galactose; also able to transport glucose galactose transport|galactose metabolic process galactose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YOR052C YOR052C hom FT NUCLEUS 0.0196976890016753 0.253956379679859 995 Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YBL071W-A KTI11 hom FT RNA PROCESSING|NUCLEUS 0.0196918982888674 0.254237684623982 996 Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs peptidyl-diphthamide biosynthetic process from peptidyl-histidine|tRNA wobble uridine modification electron carrier activity|iron ion binding|zinc ion binding nucleus|cytoplasm
YBR034C HMT1 hom FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION|NUCLEUS 0.0196777061997884 0.25443850686617 997 Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region. mRNA export from nucleus|negative regulation of DNA-dependent transcription, termination|positive regulation of transcription elongation from RNA polymerase II promoter|peptidyl-arginine methylation protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity nucleus
YGL069C_d YGL069C het 0.0196629306454864 0.254795407308299 998 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YDR302W GPI11 het FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0196424586931048 0.25529047797861 999 ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog GPI anchor biosynthetic process mannose-ethanolamine phosphotransferase activity integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YLR224W_p YLR224W hom FT PROTEOLYSIS 0.0196400326473513 0.255349191008982 1000 F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YMR272C SCS7 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0196394919765759 0.25571688246811 1001 Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth inositolphosphoceramide metabolic process fatty acid alpha-hydroxylase activity integral to membrane|endoplasmic reticulum|membrane
YJL065C DLS1 hom FT GENE SILENCING|NUCLEUS 0.0196310332660971 0.255850739561305 1002 Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication chromatin silencing at telomere molecular_function chromatin accessibility complex|nucleus
YEL047C FRD1 hom FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.0196291556880645 0.255612540959246 1003 Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication cellular response to anoxia fumarate reductase (NADH) activity cytosol|mitochondrion|ribosome|plasma membrane
YJR083C ACF4 hom 0.0196199324161559 0.255836000061946 1004 Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate biological_process molecular_function cellular_component
YER144C UBP5 hom FT PROTEOLYSIS|SITE OF POLARIZED GROWTH 0.0196116887696475 0.256035839841277 1005 Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck protein deubiquitination ubiquitin-specific protease activity incipient cellular bud site|cellular bud neck
YLR073C RFU1 hom 0.0196018668929363 0.25627408003705 1006 Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes regulation of ubiquitin homeostasis enzyme inhibitor activity endosome
YAL015C NTG1 hom FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|MITOCHONDRION 0.019588662685443 0.256594604767237 1007 DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication DNA repair|cellular response to oxidative stress|base-excision repair|base-excision repair, AP site formation|positive regulation of mitochondrial DNA replication oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|oxidized purine nucleobase lesion DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity mitochondrion|nucleus
YML106W URA5 hom FT NUCLEOTIDE METABOLISM|NUCLEUS 0.0195588218398332 0.257319999151109 1008 Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication 'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process orotate phosphoribosyltransferase activity nucleus|cytoplasm
YNL117W MLS1 hom FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM 0.0195485691462811 0.257569557541933 1009 Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic glyoxylate cycle malate synthase activity peroxisomal matrix|cytoplasm
YIL002C INP51 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|CYTOSKELETON 0.0195327589261294 0.258025702548923 1010 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth phosphatidylinositol dephosphorylation phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity membrane|cytoplasm
YOR291W YPK9 hom FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS 0.0195185736193327 0.258584770649051 1011 Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YGR047C TFC4 het FT NUCLEUS 0.0195164816272833 0.258351676609019 1012 One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending transcription factor TFIIIC complex
YDR057W YOS9 hom FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX 0.0194638757724134 0.259637478643191 1013 ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family ER-associated protein catabolic process oligosaccharide binding luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum lumen
YPL101W ELP4 hom FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS 0.0194503747946323 0.259968185034361 1014 Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification ATPase activity|tRNA binding Elongator holoenzyme complex|cytoplasm
YPL127C HHO1 hom FT CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0194381702521137 0.260267385964434 1015 Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination negative regulation of DNA recombination|negative regulation of chromatin silencing|regulation of transcription, DNA-dependent DNA binding nucleus|nuclear nucleosome
YDR323C PEP7 hom FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT 0.0194271794899809 0.260537034181605 1016 Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport phosphatidylinositol-3-phosphate binding external side of endosome membrane|cytoplasm
YDL058W USO1 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|CYTOSKELETON 0.0194221364816958 0.26101653061963 1017 Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex Golgi vesicle docking|ER to Golgi vesicle-mediated transport|SNARE complex assembly molecular_function integral to membrane|ER to Golgi transport vesicle membrane|Golgi membrane
YLR328W NMA1 hom FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.0193779298243244 0.261747701462741 1018 Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication NAD biosynthetic process nicotinamide-nucleotide adenylyltransferase activity nucleus|cytoplasm
YCR022C_d YCR022C hom 0.0193770283278345 0.261769898427787 1019 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene Unknown Unknown Unknown
YGR113W DAM1 het FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.0193598831770056 0.262405830179137 1020 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization microtubule binding|structural constituent of cytoskeleton spindle midzone|DASH complex|condensed nuclear chromosome kinetochore|kinetochore microtubule|spindle
YEL041W YEF1 hom FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM 0.0193359839422648 0.262781885273694 1021 ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication NADP biosynthetic process NAD+ kinase activity|NADH kinase activity cellular_component
YER056C FCY2 hom FT PLASMA MEMBRANE 0.0193332582577366 0.262849184990642 1022 Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress cytosine transport|cytidine transport|purine nucleobase transport|transmembrane transport nucleobase transmembrane transporter activity|cytidine transmembrane transporter activity integral to membrane|plasma membrane
YDR146C SWI5 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS 0.0192840147828189 0.264067101542798 1023 Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication positive regulation of mating type switching|regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter RNA polymerase II distal enhancer sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|mediator complex binding nucleus|cytoplasm
YLR319C BUD6 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.019283818747569 0.264071957754684 1024 Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate bipolar cellular bud site selection|positive regulation of formin-nucleated actin cable assembly|cellular bud site selection|Rho protein signal transduction|extrachromosomal circular DNA localization involved in cell aging|establishment of cell polarity|response to osmotic stress|cytokinesis cytoskeletal regulatory protein binding polarisome|actin cap|spindle pole body|mating projection tip
YKL010C UFD4 hom FT PROTEOLYSIS|MITOCHONDRION 0.0192652897522378 0.264887678479941 1025 Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress protein monoubiquitination|protein polyubiquitination ubiquitin-protein ligase activity mitochondrion|cytoplasm
YBR184W_p YBR184W hom 0.0192519435402328 0.264862393611549 1026 Putative protein of unknown function; YBR184W is not an essential gene biological_process molecular_function cellular_component
YDR046C BAP3 hom FT MITOCHONDRION|PLASMA MEMBRANE 0.0192447607933905 0.265040734883724 1027 Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication amino acid transport|transmembrane transport amino acid transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YNL184C_p YNL184C hom 0.0192319604578345 0.265358760907669 1028 Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YBR279W PAF1 hom FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING|NUCLEUS|CHROMOSOME|RNA POL II, HOLOENZYME 0.0192038554619907 0.266057954679234 1029 Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1 negative regulation of DNA recombination|mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of transcription-coupled nucleotide-excision repair|rRNA processing|transcription elongation from RNA polymerase I promoter|regulation of chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin silencing at rDNA|Unknown|snoRNA 3'-end processing|transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YBL050W SEC17 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION 0.0192025516542511 0.266090421438591 1030 Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP autophagy|SNARE complex disassembly|vesicle fusion with Golgi apparatus|vacuole fusion, non-autophagic ATPase activator activity|soluble NSF attachment protein activity SNARE complex|cytosol|extrinsic to membrane
YLR092W SUL2 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0191919246630639 0.266355151041733 1031 High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates sulfate transport sulfate transmembrane transporter activity integral to membrane|plasma membrane
YLR147C SMD3 het FT RNA PROCESSING|NUCLEUS 0.0191631106120676 0.267502190596213 1032 Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3 mRNA splicing, via spliceosome mRNA binding commitment complex|U1 snRNP|U2-type prespliceosome|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YKR089C TGL4 hom FT LIPID METABOLISM|CELL DIVISION 0.0191380733543788 0.267699428866526 1033 Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p phospholipid metabolic process|triglyceride catabolic process|triglyceride mobilization|cell budding lysophosphatidic acid acyltransferase activity|triglyceride lipase activity|calcium-independent phospholipase A2 activity|sterol esterase activity lipid particle
YDR314C RAD34 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.0191334626506603 0.267814741039639 1034 Protein involved in nucleotide excision repair (NER); homologous to RAD4 nucleotide-excision repair molecular_function nucleus
YPR148C YPR148C hom 0.0191297853718137 0.267906733021097 1035 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function ribosome|cytoplasm
YBL008W-A_p YBL008W-A hom 0.019121628601579 0.2685394142264 1036 Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YOR366W_d YOR366W hom 0.0191033730291391 0.268568110410185 1037 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C Unknown Unknown Unknown
YBL107C MIC23 hom 0.0190936111071543 0.268812836932077 1038 Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C) biological_process molecular_function cytoplasm
YNL136W EAF7 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.0190928811493051 0.268831142759831 1039 Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A DNA repair|histone acetylation|regulation of transcription from RNA polymerase II promoter molecular_function histone acetyltransferase complex|nucleus|NuA4 histone acetyltransferase complex
YDR135C YCF1 hom FT NUCLEOTIDE METABOLISM 0.0190796889618481 0.269162122891069 1040 Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR bilirubin transport|response to metal ion|transmembrane transport bilirubin transmembrane transporter activity|glutathione S-conjugate-exporting ATPase activity fungal-type vacuole membrane|integral to membrane
YGL192W IME4 hom FT CELL CYCLE|NUCLEUS 0.0190710314605471 0.269593779027485 1041 Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids meiosis|mRNA methylation mRNA (N6-adenosine)-methyltransferase activity cellular_component
YOL021C DIS3 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION 0.0190677465945798 0.269533397995037 1042 Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nonfunctional rRNA decay|nuclear polyadenylation-dependent mRNA catabolic process|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing 3'-5'-exoribonuclease activity|endoribonuclease activity|tRNA binding mitochondrion|nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YBR067C TIP1 hom FT CELL WALL ORG/BIOGENESIS 0.0190662773441552 0.269498894811627 1043 Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins fungal-type cell wall organization structural constituent of cell wall|lipase activity fungal-type cell wall
YOR290C SNF2 hom FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|RSC COMPLEX 0.0190577247621675 0.269713804948563 1044 Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p cellular alcohol catabolic process|ATP-dependent chromatin remodeling|double-strand break repair|strand invasion|positive regulation of mating type switching|sucrose catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|nucleosome mobilization|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter histone acetyl-lysine binding|RNA polymerase II activating transcription factor binding|DNA-dependent ATPase activity|nucleosomal DNA binding SWI/SNF complex|nucleus
YCR064C_d YCR064C hom FF 0.0190068918467742 0.271065024367173 1045 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 Unknown Unknown Unknown
YML042W CAT2 hom FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION 0.0189922947230429 0.27136182601673 1046 Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes carnitine metabolic process carnitine O-acetyltransferase activity mitochondrion|peroxisomal matrix|peroxisome
YKR022C NTR2 het FT RNA PROCESSING|NUCLEUS|ENDOPLASMIC RETICULUM 0.0189850009100021 0.271832016060315 1047 Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly spliceosomal complex disassembly|mRNA splicing, via spliceosome molecular_function endoplasmic reticulum|U2-type post-mRNA release spliceosomal complex|nucleus|spliceosomal complex|cytoplasm
YPR086W SUA7 het FT TRANSCRIPTION FROM RNA POL II|TRANSLATION|NUCLEUS 0.0189839823769254 0.271929312303299 1048 Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II transcriptional start site selection at RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|Unknown TBP-class protein binding|RNA polymerase II core binding|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|core RNA polymerase II recruiting transcription factor activity nucleus
YFL045C SEC53 het FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM 0.018972447042165 0.272650755250593 1049 Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen protein targeting to ER phosphomannomutase activity cytosol
YGL116W CDC20 het FF|FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0189460371665592 0.272531091588546 1050 Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress spindle checkpoint|activation of mitotic anaphase-promoting complex activity|meiotic anaphase I|positive regulation of protein catabolic process|activation of anaphase-promoting complex activity involved in meiotic cell cycle|positive regulation of mitotic metaphase/anaphase transition|cyclin catabolic process anaphase-promoting complex binding|ubiquitin-protein ligase activator activity mitotic checkpoint complex|anaphase-promoting complex
YKL145W RPT1 het FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS 0.0189155517605927 0.273303561119511 1051 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of protein catabolic process|proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process ATPase activity proteasome regulatory particle, base subcomplex
YMR092C AIP1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0188986077435097 0.273733551873362 1052 Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress actin filament depolymerization|response to osmotic stress actin binding nucleus|mating projection tip|cytoplasm|actin cortical patch
YOL063C CRT10 hom FT TRANSCRIPTION FROM RNA POL II 0.0188949833467631 0.273825588682268 1053 Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YLR406C-A_p YLR406C-A hom 0.0188872177886399 0.274022856023778 1054 Putative protein of unknown function biological_process molecular_function cellular_component
YDR270W CCC2 hom FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0188868711368156 0.274031664232161 1055 Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism cellular iron ion homeostasis|copper ion export|transmembrane transport copper ion binding|cation-transporting ATPase activity integral to membrane|trans-Golgi network transport vesicle membrane
YOR310C NOP58 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0188517450759245 0.275211651856452 1056 Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function box C/D snoRNP complex|small-subunit processome|nucleolus|90S preribosome
YGR132C PHB1 hom FT MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0188378293537442 0.275781344694442 1057 Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging|mitochondrion morphogenesis|inner mitochondrial membrane organization molecular_function mitochondrion|mitochondrial inner membrane
YDR091C RLI1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEOTIDE METABOLISM|NUCLEUS|RIBOSOME 0.0188331133462392 0.275399957108242 1058 Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species translational termination|ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|translational initiation ATPase activity|iron ion binding cytosolic ribosome|nucleus|cytoplasm
YGL021W ALK1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION 0.0188291073531763 0.276003761303687 1059 Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins mitosis|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity cellular_component
YER039C HVG1 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.0188240843309386 0.275630228254107 1060 Protein of unknown function, has homology to Vrg4p biological_process molecular_function integral to membrane
YJL183W MNN11 hom FT CARBOHYDRATE METABOLISM|GOLGI APPARATUS 0.0188169168747589 0.276027996848797 1061 Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p protein glycosylation alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YGL126W SCS3 hom FT LIPID METABOLISM|ENDOPLASMIC RETICULUM 0.0187868500877175 0.277083079941027 1062 Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol phospholipid metabolic process molecular_function integral to membrane|endoplasmic reticulum
YKR030W GMH1 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.0187708414959756 0.27699077466914 1063 Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting transport molecular_function integral to membrane|integral to Golgi membrane
YOR283W YOR283W hom FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS 0.0187688311049428 0.277042236874906 1064 Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene dephosphorylation phosphatase activity nucleus|cytoplasm
YHL030W ECM29 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEUS 0.0187640641496677 0.27716428793427 1065 Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress proteasome assembly protein complex scaffold proteasome complex|nucleus|cytoplasm
YDR445C_d YDR445C hom 0.0187445441673709 0.277664451048548 1066 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL074C BRE1 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0187344411820956 0.277923562327974 1067 E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control mitotic cell cycle G1/S transition DNA damage checkpoint|intra-S DNA damage checkpoint|meiotic DNA double-strand break formation|histone monoubiquitination|double-strand break repair via homologous recombination|transcription from RNA polymerase II promoter|chromatin silencing at telomere ubiquitin-protein ligase activity nuclear chromatin
YML041C VPS71 hom FF|FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|VACUOLAR TRANSPORT|NUCLEUS|CHROMOSOME 0.0186534578677219 0.280580849550181 1068 Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting chromatin remodeling|protein targeting to vacuole|histone exchange nucleosome binding Swr1 complex|nucleus
YOR032C HMS1 hom FT NUCLEUS 0.0186503967777532 0.280085426910294 1069 Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant pseudohyphal growth sequence-specific DNA binding transcription factor activity cellular_component
YIR020W-A_d YIR020W-A hom 0.0186127469641835 0.281057583179484 1070 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YPL214C THI6 hom 0.0185487405746944 0.283002796263582 1071 Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern thiamine biosynthetic process hydroxyethylthiazole kinase activity|thiamine-phosphate diphosphorylase activity cytosol|cytoplasm
YPL006W NCR1 hom FT LIPID METABOLISM 0.0185434962039814 0.282923462448519 1072 Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein sphingolipid metabolic process sphingolipid transporter activity fungal-type vacuole membrane|integral to membrane
YOR247W SRL1 hom FT CELL WALL ORG/BIOGENESIS|SITE OF POLARIZED GROWTH 0.0185413567788272 0.282907230335234 1073 Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication fungal-type cell wall organization|nucleobase-containing compound metabolic process molecular_function fungal-type cell wall|fungal-type vacuole|cytoplasm|cellular bud tip
YPL103C FMP30 hom FT LIPID METABOLISM|MITOCHONDRION 0.0184992404009528 0.28400228136745 1074 Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D N-acylphosphatidylethanolamine metabolic process|N-acylethanolamine metabolic process NAPE-specific phospholipase D activity mitochondrion|integral to mitochondrial inner membrane
YMR026C PEX12 hom FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION 0.018491425724161 0.284780925388746 1075 C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder protein import into peroxisome matrix ubiquitin-protein ligase activity|protein binding integral to peroxisomal membrane
YBR178W_d YBR178W hom 0.0184910270163301 0.284216168044261 1076 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C Unknown Unknown Unknown
YAL030W SNC1 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0184726609206195 0.285054182393338 1077 Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion SNAP receptor activity SNARE complex|trans-Golgi network|endosome|transport vesicle membrane|plasma membrane|cellular bud neck
YPL036W PMA2 hom FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION|PLASMA MEMBRANE 0.0184658843377619 0.284871591707488 1078 Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential proton transport|regulation of pH hydrogen-exporting ATPase activity, phosphorylative mechanism mitochondrion|integral to membrane|plasma membrane
YLR430W SEN1 het FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0184597067445634 0.285032786533994 1079 Presumed helicase and subunit of the Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3' end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; has a separate role in coordinating DNA replication with transcription, by associating with moving replication forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, which is implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of ALS tRNA processing|mRNA 3'-end processing|termination of RNA polymerase II transcription|mRNA polyadenylation|snoRNA 3'-end processing|rRNA processing|snRNA processing ATP-dependent 5'-3' DNA helicase activity|DNA-dependent ATPase activity|RNA-dependent ATPase activity|ATP-dependent 5'-3' RNA helicase activity|protein domain specific binding Nrd1 complex|nucleus
YNL199C GCR2 hom FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM|NUCLEUS 0.0184537162635377 0.285189157832033 1080 Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity nuclear envelope|nucleus
YLR282C_d YLR282C hom 0.0184515894492733 0.285460261385376 1081 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Unknown Unknown Unknown
YNR071C_p YNR071C hom FT CARBOHYDRATE METABOLISM 0.0184407425011809 0.285528014530643 1082 Putative aldose 1-epimerase biological_process molecular_function cellular_component
YMR304W UBP15 hom FT PROTEOLYSIS 0.0184252389195057 0.286220836897267 1083 Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p protein deubiquitination ubiquitin-specific protease activity peroxisome|cytoplasm
YIL045W PIG2 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.0184223383417136 0.286009172198686 1084 Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase regulation of glycogen biosynthetic process protein phosphatase type 1 regulator activity cytoplasm
YLR459W GAB1 het FT CELL CYCLE|LIPID METABOLISM|CELL DIVISION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0184165782925626 0.286159875164409 1085 GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI attachment of GPI anchor to protein GPI-anchor transamidase activity integral to membrane|GPI-anchor transamidase complex
YGR151C_d YGR151C hom 0.0184128103338287 0.286474122925904 1086 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress Unknown Unknown Unknown
YNL281W HCH1 hom FT NUCLEOTIDE METABOLISM|NUCLEUS 0.0184033893240884 0.28650514649097 1087 Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress protein folding|response to stress ATPase activator activity|chaperone binding nucleus|cytoplasm
YGR026W_p YGR026W hom FT PLASMA MEMBRANE 0.0183928799139069 0.286780471456962 1088 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function integral to membrane
YMR298W LIP1 het FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0183894062849372 0.286871512654475 1089 Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis ceramide biosynthetic process sphingosine N-acyltransferase activity nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane
YDR268W MSW1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0183726472411099 0.287311028598312 1090 Mitochondrial tryptophanyl-tRNA synthetase mitochondrial tryptophanyl-tRNA aminoacylation tryptophan-tRNA ligase activity mitochondrion
YDL180W_p YDL180W hom 0.0183673716025516 0.287449479326842 1091 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole biological_process molecular_function integral to membrane|fungal-type vacuole
YOR136W IDH2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.0183588031400159 0.28767444085465 1092 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated glutamate biosynthetic process|isocitrate metabolic process|tricarboxylic acid cycle isocitrate dehydrogenase (NAD+) activity mitochondrial isocitrate dehydrogenase complex (NAD+)|mitochondrion|mitochondrial matrix
YDR029W_d YDR029W hom 0.0183566821825566 0.28953414460109 1093 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR133W CKI1 hom FT LIPID METABOLISM 0.0183372462581082 0.288240933041675 1094 Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolamine kinase activity|choline kinase activity cytoplasm
YPL266W DIM1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0183363219654888 0.288265239277722 1095 Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing rRNA modification|rRNA processing rRNA (adenine-N6,N6-)-dimethyltransferase activity nucleolus|90S preribosome
YGR054W YGR054W hom FT TRANSLATION 0.018301579969139 0.289179855646174 1096 Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A translational initiation translation initiation factor activity cytosolic ribosome|cytosolic small ribosomal subunit|ribosome
YGR137W_d YGR137W hom 0.018297886768866 0.289349111625526 1097 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR235C RNA1 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|GENE SILENCING|NUCLEUS 0.0182641325992122 0.290167879579216 1098 GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport rRNA metabolic process|ribosomal subunit export from nucleus|tRNA metabolic process|rRNA export from nucleus|RNA import into nucleus|protein import into nucleus|chromatin silencing at telomere Ran GTPase activator activity cytosol|integral to membrane|nucleus
YLL011W SOF1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0182355158651969 0.290924442173345 1099 Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|nucleolus|90S preribosome
YDL051W LHP1 hom FT RNA PROCESSING|NUCLEUS 0.0182337839214787 0.290970273420443 1100 RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen tRNA processing RNA binding|tRNA binding nucleoplasm|nucleolus|nucleus
YOR332W VMA4 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS 0.0182176721746589 0.291900996754051 1101 Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane|integral to membrane
YOR236W DFR1 het FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM 0.0181937228172895 0.292031737726304 1102 Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism tetrahydrofolate biosynthetic process|dihydrofolate metabolic process dihydrofolate reductase activity|mRNA binding cytosol
YGR002C SWC4 het FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|HISTONE ACETYLTRANSFERASE 0.0181657582461992 0.292774229993272 1103 Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex DNA repair|histone acetylation|chromosome organization|chromatin modification|chromatin remodeling|histone exchange|establishment of mitotic sister chromatid cohesion DNA binding Swr1 complex|histone acetyltransferase complex|nucleus|NuA4 histone acetyltransferase complex
YLR047C FRE8 hom FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY 0.0181430181469745 0.293378939554113 1104 Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p cellular metal ion homeostasis oxidoreductase activity, oxidizing metal ions integral to membrane|membrane
YOR342C YOR342C hom FT NUCLEUS 0.0180991760638202 0.294547160478059 1105 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YLR215C CDC123 het FT CELL CYCLE|TRANSLATION|CELL DIVISION 0.0180669613116835 0.29547955545279 1106 Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein regulation of mitotic cell cycle|regulation of translation molecular_function cytoplasm
YDR300C PRO1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0180497315449921 0.2958683989776 1107 Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication proline biosynthetic process glutamate 5-kinase activity cytoplasm
YCR016W_p YCR016W hom FT NUCLEUS 0.0180437902365105 0.296027426937734 1108 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis biological_process molecular_function nucleolus|nucleus
YCL059C KRR1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0179777950584481 0.297797731239714 1109 Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit biogenesis|rRNA processing molecular_function small-subunit processome|nucleolus|90S preribosome
YOR253W NAT5 hom FT RIBOSOME 0.0179649712028729 0.29814254676339 1110 Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatA complex|cytosolic ribosome
YPL166W ATG29 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS 0.017963918540056 0.298314985474125 1111 Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy molecular_function pre-autophagosomal structure|cytoplasm
YOL034W SMC5 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0179340697295833 0.299118680315601 1112 Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair DNA repair|resolution of recombination intermediates|recombinational repair|rDNA separation damaged DNA binding|single-stranded DNA binding|ATPase activity Smc5-Smc6 complex|nucleus
YPR101W SNT309 hom FT RNA PROCESSING|NUCLEUS 0.0179338379436757 0.298980785290397 1113 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p mRNA splicing, via spliceosome first spliceosomal transesterification activity Prp19 complex|U2-type catalytic step 1 spliceosome
YML091C RPM2 het FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION|NUCLEUS|MITOCHONDRION 0.0179257747393177 0.299198136809006 1114 Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus cytoplasmic translation|tRNA 5'-leader removal|mRNA processing|mitochondrion organization|RNA processing|positive regulation of transcription from RNA polymerase II promoter ribonuclease P activity mitochondrion|nucleus|mitochondrial matrix|cytoplasmic mRNA processing body|mitochondrial ribonuclease P complex
YGR015C_p YGR015C hom FT MITOCHONDRION 0.0179220638087702 0.299298203957186 1115 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion biological_process molecular_function mitochondrion
YKL081W TEF4 hom FT TRANSLATION|MITOCHONDRION|RIBOSOME 0.0179154104832371 0.299477670174943 1116 Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex translational elongation translation elongation factor activity mitochondrion|ribosome|eukaryotic translation elongation factor 1 complex
YPL067C_p YPL067C hom 0.0178983168659979 0.299939080844638 1117 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene biological_process molecular_function cytoplasm
YGR191W HIP1 het FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0178968467466372 0.29997878612147 1118 High-affinity histidine permease, also involved in the transport of manganese ions manganese ion transport|histidine transport high affinity L-histidine transmembrane transporter activity integral to membrane|plasma membrane
YER045C ACA1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0178880496024875 0.300216454343814 1119 ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YGL011C SCL1 het FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION 0.0178850672078427 0.300297056740362 1120 Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function mitochondrion|proteasome core complex, alpha-subunit complex|nucleus|proteasome storage granule|nuclear outer membrane-endoplasmic reticulum membrane network
YIR035C_p YIR035C hom FT OXIDATION-REDUCTION PROCESS 0.0178403965374165 0.301722382597105 1121 Putative cytoplasmic short-chain dehydrogenase/reductase biological_process molecular_function integral to membrane|cytoplasm
YLR173W_p YLR173W hom 0.0178112223349147 0.302297391539255 1122 Putative protein of unknown function biological_process molecular_function cellular_component
YBR240C THI2 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0178099240769889 0.30233263826586 1123 Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type thiamine biosynthetic process|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription nucleus
YDL209C CWC2 het FT CELL CYCLE|RNA PROCESSING|NUCLEUS 0.0177892471373092 0.303688695556049 1124 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2 mRNA cis splicing, via spliceosome|mRNA splicing, via spliceosome|spliceosomal snRNP assembly pre-mRNA binding|first spliceosomal transesterification activity|U6 snRNA binding|second spliceosomal transesterification activity Prp19 complex|U2-type catalytic step 1 spliceosome|U2-type catalytic step 2 spliceosome
YMR027W_p YMR027W hom FT NUCLEUS 0.0177601557062148 0.303685872570572 1125 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YKL221W MCH2 hom 0.017758708920196 0.303725271697515 1126 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport transport monocarboxylic acid transmembrane transporter activity|transporter activity integral to membrane|membrane
YGR186W TFG1 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0177296899603576 0.304516237880054 1127 TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74 transcription initiation from RNA polymerase II promoter|transcriptional start site selection at RNA polymerase II promoter|dephosphorylation of RNA polymerase II C-terminal domain|promoter clearance from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|regulation of protein serine/threonine phosphatase activity core RNA polymerase II binding transcription factor activity|protein phosphatase activator activity|core RNA polymerase II recruiting transcription factor activity transcription factor TFIIF complex
YPR169W JIP5 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.0177221514541832 0.304721937473653 1128 Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein ribosomal large subunit biogenesis molecular_function nucleolus|nucleus
YPL031C PHO85 hom FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES A 0.0176772669702564 0.305948586927966 1129 Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle regulation of transcription involved in G1/S phase of mitotic cell cycle|negative regulation of calcium-mediated signaling|regulation of protein stability|regulation of protein localization|protein phosphorylation|response to DNA damage stimulus|negative regulation of phosphate metabolic process|fungal-type cell wall organization|regulation of establishment or maintenance of cell polarity|negative regulation of glycogen biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of macroautophagy|negative regulation of macroautophagy protein kinase activity|cyclin-dependent protein kinase activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YPR039W_d YPR039W hom 0.0176454085346369 0.306821229929411 1130 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W Unknown Unknown Unknown
YDR062W LCB2 het FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0176301396791924 0.307240046893678 1131 Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine sphingolipid biosynthetic process serine C-palmitoyltransferase activity SPOTS complex|serine C-palmitoyltransferase complex
YEL013W VAC8 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.0176271443135674 0.307322252627937 1132 Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions piecemeal microautophagy of nucleus|vacuole inheritance|CVT vesicle assembly|vacuole fusion, non-autophagic|macroautophagy|nucleus-vacuole junction assembly protein anchor fungal-type vacuole membrane|nucleus-vacuole junction|Myo2p-Vac17p-Vac8p transport complex
YMR120C ADE17 hom FT NUCLEOTIDE METABOLISM 0.017620746428074 0.307497886908142 1133 Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity cytosol|plasma membrane
YPL169C MEX67 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0176206696874718 0.307788668192824 1134 Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP mRNA export from nucleus|ribosomal large subunit export from nucleus protein binding|RNA binding|structural constituent of nuclear pore integral to membrane|nuclear RNA export factor complex|nuclear pore|cytoplasm
YDR473C PRP3 het FT RNA PROCESSING|NUCLEUS 0.0176164106735288 0.30819465532075 1135 Splicing factor, component of the U4/U6-U5 snRNP complex mRNA splicing, via spliceosome molecular_function U4/U6 x U5 tri-snRNP complex
YJR031C GEA1 hom FT VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|GOLGI APPARATUS 0.0176125764419751 0.307722265303071 1136 Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization ARF guanyl-nucleotide exchange factor activity integral to membrane|Golgi cis cisterna|Golgi-associated vesicle|extrinsic to membrane
YOR368W RAD17 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0175937949705233 0.308454971080412 1137 Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins double-strand break repair|reciprocal meiotic recombination|DNA damage checkpoint double-stranded DNA binding nucleus|checkpoint clamp complex
YER124C DSE1 hom FT CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|SITE OF POLARIZED GROWTH 0.0175665731306952 0.308987709941021 1138 Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress cytokinesis, completion of separation|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|invasive growth in response to glucose limitation molecular_function cellular bud neck
YLR358C_p YLR358C hom 0.0175493484685271 0.309751121012147 1139 Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W biological_process molecular_function cellular_component
YKL183W LOT5 hom FT NUCLEUS 0.0175426513258776 0.309719247690762 1140 Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YOR343C_d YOR343C hom 0.0175221553841894 0.310212797451358 1141 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR004C AIM45 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0175188465738739 0.310304185984444 1142 Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response biological_process molecular_function mitochondrion
YLR288C MEC3 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0175163556359568 0.310372996802083 1143 DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 telomere maintenance via recombination|DNA damage checkpoint|DNA metabolic process|chromatin silencing at telomere DNA binding nucleus|checkpoint clamp complex
YHR154W RTT107 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0174904829745984 0.311088310496267 1144 Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress negative regulation of transposition, RNA-mediated|double-strand break repair molecular_function Cul8-RING ubiquitin ligase complex|nucleus
YDR311W TFB1 het FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME 0.0174904473236097 0.311089296905372 1145 Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators phosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase I promoter|nucleotide-excision repair|transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YHR125W_d YHR125W hom 0.0174683552332725 0.311700948353805 1146 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR026W BUB3 hom FT CELL CYCLE|NUCLEUS|CHROMOSOME|KINETOCHORE 0.0174611162972387 0.311973697506245 1147 Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p mitotic cell cycle G2/M transition decatenation checkpoint|mitotic cell cycle spindle assembly checkpoint ubiquitin binding mitotic checkpoint complex|condensed nuclear chromosome kinetochore
YGR099W TEL2 het FT PROTEIN LOCALIZATION|NUCLEUS|CHROMOSOME 0.017441561671562 0.31266036939385 1148 Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1 protein localization to chromosome|telomere maintenance via telomerase|telomere maintenance telomeric DNA binding ASTRA complex|nuclear telomere cap complex
YGL044C RNA15 het FT RNA PROCESSING|NUCLEUS 0.0174402576165003 0.312480015654442 1149 Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping mRNA cleavage|mRNA polyadenylation mRNA binding|protein heterodimerization activity mRNA cleavage factor complex
YOR320C GNT1 hom FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0174099453232506 0.313321926229138 1150 N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus protein N-linked glycosylation acetylglucosaminyltransferase activity Golgi medial cisterna
YLR312W-A MRPL15 hom FT RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0173969262482857 0.313900532443935 1151 Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YNL307C MCK1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION 0.0173879205128876 0.313934590931462 1152 Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family meiosis|double-strand break repair via nonhomologous end joining|ascospore formation|protein phosphorylation|response to stress|mitotic sister chromatid segregation protein serine/threonine/tyrosine kinase activity|protein serine/threonine kinase activity|protein kinase activity cellular_component
YIL031W ULP2 het FT CELL CYCLE|PROTEOLYSIS|NUCLEUS 0.0173853928672276 0.314004952870217 1153 Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate plasmid maintenance|protein desumoylation|chromosome condensation|mitotic cell cycle spindle assembly checkpoint cysteine-type peptidase activity|SUMO-specific protease activity nucleus
YMR283C RIT1 hom FT RNA PROCESSING 0.0173781580124916 0.314495186580753 1154 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA charged-tRNA amino acid modification transferase activity, transferring pentosyl groups cytoplasm
YPL222W_p FMP40 hom FT MITOCHONDRION 0.0173723244863283 0.314729932882508 1155 Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YEL054C RPL12A hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0173657778625086 0.314551327142879 1156 Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YOL138C RTC1 hom 0.017358686685485 0.314749004936265 1157 Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif biological_process molecular_function ribosome|fungal-type vacuole|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YNL084C END3 hom FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON 0.0173545232213863 0.314865106115976 1158 EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p bipolar cellular bud site selection|ascospore wall assembly|endocytosis|actin filament organization|cytokinesis|actin cortical patch assembly protein binding, bridging mating projection tip|actin cortical patch
YML109W ZDS2 hom FT PROTEIN LOCALIZATION|CELL CYCLE|GENE SILENCING|NUCLEUS|SITE OF POLARIZED GROWTH 0.0173448606535042 0.315134662148345 1159 Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|establishment of cell polarity|regulation of protein localization|chromatin silencing at rDNA|cell aging molecular_function nucleus|cellular bud neck|cellular bud tip|cytoplasm
YBR016W YBR016W hom FT PLASMA MEMBRANE 0.0173363765019945 0.315371468903456 1160 Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication biological_process molecular_function cellular bud membrane|plasma membrane|mating projection membrane
YNR067C DSE4 hom FT CELL WALL ORG/BIOGENESIS|CELL DIVISION 0.0172867387721293 0.316759281400811 1161 Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother cytokinesis, completion of separation glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall|extracellular region|cell septum
YOR144C ELG1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CHROMOSOME 0.0172533254775417 0.317695729558981 1162 Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication negative regulation of DNA recombination|negative regulation of transposition, RNA-mediated|telomere maintenance|double-strand break repair via homologous recombination|DNA-dependent DNA replication|mitotic sister chromatid cohesion chromatin binding Elg1 RFC-like complex|mitochondrion|nucleus|cytoplasm
YDL120W YFH1 het FT KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|COFACTOR METABOLISM|MITOCHONDRION 0.0172431650117864 0.31798084820292 1163 Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia cellular iron ion homeostasis|iron-sulfur cluster assembly|glutathione metabolic process ferrous iron binding|ferroxidase activity|iron chaperone activity mitochondrion|mitochondrial matrix
YOR206W NOC2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION 0.0172314362981215 0.318671223131385 1164 Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors ribosomal subunit export from nucleus|ribosome assembly molecular_function mitochondrion|nucleus|Noc2p-Noc3p complex|Noc1p-Noc2p complex
YCR067C SED4 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.0172292906891274 0.318659243292048 1165 Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p positive regulation of GTPase activity|regulation of COPII vesicle coating Sar GTPase activator activity integral to endoplasmic reticulum membrane
YPR191W QCR2 hom FT OXIDATION-REDUCTION PROCESS|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0172227908943524 0.318553082783974 1166 Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial crista|mitochondrial respiratory chain complex III
YHR124W NDT80 hom FT CELL CYCLE|CELL DIVISION|NUCLEUS|CHROMOSOME 0.0172072057032193 0.318991268666213 1167 Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) meiosis|transcription, DNA-dependent sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nuclear chromosome
YDR019C GCV1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION 0.017186583603111 0.319571675780254 1168 T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm glycine catabolic process|glycine metabolic process|one-carbon metabolic process glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YIL043C CBR1 hom FT OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.0171862671175723 0.319580588613835 1169 Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia biological_process cytochrome-b5 reductase activity mitochondrial outer membrane|mitochondrion
YBL091C MAP2 hom FT PROTEOLYSIS 0.0171767365467527 0.319849063731654 1170 Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p protein initiator methionine removal involved in protein maturation metalloaminopeptidase activity cytoplasm
YGR089W NNF2 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0171718829742787 0.319985844976436 1171 Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation biological_process molecular_function integral to membrane
YIR034C LYS1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 0.0171574598419732 0.320392536946512 1172 Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity lysine biosynthetic process|lysine biosynthetic process via aminoadipic acid saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|mRNA binding cytoplasm
YGL190C CDC55 hom FT CELL CYCLE|SIGNALING|NUCLEUS|SITE OF POLARIZED GROWTH 0.0171547740400469 0.320468306330471 1173 Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion negative regulation of exit from mitosis|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|protein dephosphorylation protein phosphatase type 2A regulator activity nucleus|cellular bud neck|cytoplasm|cellular bud tip
YJR045C SSC1 het FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|NUCLEUS|MITOCHONDRION 0.0171334753797291 0.321069579123266 1174 Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication protein refolding|positive regulation of endodeoxyribonuclease activity|protein import into mitochondrial matrix|protein unfolding enzyme regulator activity|ATPase activity mitochondrial nucleoid|mitochondrion|TRC complex|mitochondrial inner membrane|presequence translocase-associated import motor
YDR293C SSD1 hom FF|FT CELL CYCLE|TRANSLATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|RNA LOCALIZATION|NUCLEUS|SITE OF POLARIZED GROWTH 0.0171125659966357 0.323325662089549 1175 Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function regulation of fungal-type cell wall organization|negative regulation of translation|intracellular mRNA localization mRNA binding|mRNA 5'-UTR binding|translation repressor activity, nucleic acid binding nucleus|cellular bud|cytoplasmic stress granule|cytoplasmic mRNA processing body|cellular bud neck|cytoplasm
YGR251W NOP19 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.017079834068948 0.322587164241292 1176 Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleoplasm|nucleolus|nucleus|90S preribosome
YGR045C_d YGR045C hom 0.0170774666746783 0.322654248604364 1177 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR193W PEX27 hom FT PEROXISOME ORGANIZATION 0.0170685738293008 0.32297848031482 1178 Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p peroxisome organization molecular_function peroxisomal membrane
YLL031C GPI13 het FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.017013381078013 0.324473684083282 1179 ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein GPI anchor biosynthetic process mannose-ethanolamine phosphotransferase activity|transferase activity, transferring phosphorus-containing groups integral to membrane|endoplasmic reticulum
YCR100C_p YCR100C hom 0.0169916112274949 0.325093261891124 1180 Putative protein of unknown function biological_process molecular_function integral to membrane
YGR050C_p YGR050C hom 0.0169715245133838 0.325665619079632 1181 Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YJR122W IBA57 hom FF|FT COFACTOR METABOLISM|MITOCHONDRION 0.0169412249084975 0.327180239365784 1182 Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system iron-sulfur cluster assembly molecular_function mitochondrion|mitochondrial matrix
YEL039C CYC7 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0169170896564247 0.327436463099059 1183 Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c electron carrier activity mitochondrion|mitochondrial intermembrane space
YBL062W_d YBL062W hom 0.016900464776244 0.32769567151958 1184 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBL007C SLA1 hom FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON 0.0168989854933167 0.32874978969134 1185 Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains fungal-type cell wall organization|endocytosis|actin cortical patch assembly ubiquitin binding|protein binding, bridging cell cortex|nucleus|mating projection tip|actin cortical patch
YMR194C-A_d YMR194C-A hom 0.0168626600721506 0.328779023909223 1186 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR322C-A TIM11 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION 0.0168520911844488 0.329370925104164 1187 Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase protein oligomerization|cristae formation|ATP synthesis coupled proton transport structural molecule activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YOL112W MSB4 hom FT SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH 0.0168214388864913 0.329962922673894 1188 GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization actin filament organization Rab GTPase activator activity incipient cellular bud site|polarisome|cellular bud tip
YDR507C GIN4 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH 0.0168023062384112 0.330513360912423 1189 Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication protein autophosphorylation|budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly protein kinase activity cellular bud neck
YOL104C NDJ1 hom FT CELL CYCLE|NUCLEUS|CHROMOSOME 0.0168016463692759 0.33053235566003 1190 Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement meiotic telomere clustering|synapsis|attachment of telomeric heterochromatin to nuclear envelope|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination telomeric DNA binding nuclear chromosome, telomeric region
YLR449W FPR4 hom FT CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0167906695787253 0.330920542745862 1191 Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones histone peptidyl-prolyl isomerization|negative regulation of histone H3-K36 methylation|regulation of transcription by chromatin organization|chromatin silencing at rDNA|nucleosome assembly peptidyl-prolyl cis-trans isomerase activity|macrolide binding chromatin|nucleus
YML096W_p YML096W hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0167685599650314 0.331702049790803 1192 Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10 biological_process molecular_function cytoplasm
YPL188W POS5 hom FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION 0.0167520889702297 0.331960914289444 1193 Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress cellular response to oxidative stress|NADP biosynthetic process NADH kinase activity mitochondrion|mitochondrial matrix
YDL071C_d YDL071C hom 0.0167205962113939 0.33315929801034 1194 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W Unknown Unknown Unknown
YKR002W PAP1 het FT RNA PROCESSING|NUCLEUS 0.0166776297106776 0.334114788417107 1195 Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping mRNA polyadenylation|snoRNA polyadenylation polynucleotide adenylyltransferase activity nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex
YNR029C_p YNR029C hom 0.016664841809062 0.334485606842291 1196 Putative protein of unknown function, deletion confers reduced fitness in saline biological_process molecular_function cytoplasm
YEL033W_p MTC7 hom 0.0166568508899162 0.33522241214625 1197 Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant biological_process molecular_function cellular_component
YOR014W RTS1 hom FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CHROMOSOME SEGREGATION|NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON 0.0166457763299654 0.335111022615428 1198 B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A mitotic cell cycle spindle orientation checkpoint|cellular protein localization|meiotic sister chromatid cohesion, centromeric|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|spindle pole body|condensed nuclear chromosome, centromeric region|cellular bud neck|cytoplasm
YIR029W DAL2 hom 0.0166372514342643 0.335286564265294 1199 Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin catabolic process allantoicase activity cellular_component
YPL199C_p YPL199C hom 0.0166334884558709 0.335395900341714 1200 Putative protein of unknown function, predicted to be palmitoylated biological_process molecular_function cytoplasm
YKL094W YJU3 hom FT LIPID METABOLISM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.016613354068553 0.335981309503422 1201 Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family triglyceride metabolic process serine hydrolase activity|acylglycerol lipase activity mitochondrial outer membrane|lipid particle|plasma membrane|membrane|cytoplasm
YPR034W ARP7 het FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RSC COMPLEX 0.016596752732208 0.336464489023158 1202 Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation nucleosome mobilization|ATP-dependent chromatin remodeling|chromatin organization|nucleosome disassembly|transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter DNA translocase activity RSC complex|SWI/SNF complex|nucleus
YPL090C RPS6A hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0165804239118072 0.336940172649212 1203 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YGR163W GTR2 hom FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION|NUCLEUS|CHROMOSOME 0.0165751949167627 0.337092592631745 1204 Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD microautophagy|positive regulation of transcription from RNA polymerase II promoter GTP binding nuclear chromatin|fungal-type vacuole membrane|integral to membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YLR443W ECM7 hom FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS 0.0165167912001959 0.33879801301772 1205 Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency fungal-type cell wall organization|calcium ion transport molecular_function integral to membrane
YGR232W NAS6 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS 0.016510250644509 0.339782745130292 1206 Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6 proteolysis|proteasome regulatory particle assembly molecular_function cytosol|nucleus|proteasome regulatory particle
YLR218C COA4 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|NUCLEUS|MITOCHONDRION 0.016500965863292 0.339261072904641 1207 Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain complex assembly molecular_function nucleus|mitochondrial intermembrane space|cytoplasm
YBR265W TSC10 het FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.0164910610842973 0.339551099707735 1208 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family 3-keto-sphinganine metabolic process|sphingolipid biosynthetic process oxidoreductase activity, acting on NADH or NADPH mitochondrial outer membrane|endoplasmic reticulum|cytoplasm
YDL112W TRM3 hom FT RNA PROCESSING 0.0164900498524316 0.339580719034048 1209 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs tRNA methylation tRNA (guanine) methyltransferase activity cytoplasm
YKL017C HCS1 hom FT NUCLEUS|CHROMOSOME 0.0164709523575871 0.340140402127792 1210 Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities lagging strand elongation ATP-dependent 5'-3' DNA helicase activity DNA helicase A complex|alpha DNA polymerase:primase complex
YDR346C SVF1 hom FT RESPONSE TO OXIDATIVE STRESS|NUCLEUS 0.016441403570474 0.341007541131625 1211 Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance cellular response to oxidative stress molecular_function nucleus|cytoplasm
YOL049W GSH2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0163886806641609 0.342630234395527 1212 Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock glutathione biosynthetic process glutathione synthase activity intracellular
YAL022C FUN26 hom 0.0163849276597986 0.3426688165278 1213 Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis nucleoside transport|nicotinamide riboside transport|transmembrane transport nicotinamide riboside transporter activity|nucleoside transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|intracellular|membrane
YHL034C SBP1 hom FT TRANSLATION|NUCLEUS 0.0163695856115188 0.343121004532785 1214 Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11 negative regulation of translation|negative regulation of translation in response to stress RNA binding|eukaryotic initiation factor 4G binding nucleolus|cytoplasmic mRNA processing body|cytoplasm
YLR279W_d YLR279W hom 0.0162692668113068 0.346087165001919 1215 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR171W SEC66 hom FF|FT PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0162266117706117 0.347569047172042 1216 Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation|filamentous growth protein transporter activity integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YNL126W SPC98 het FF|FT CELL CYCLE|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON 0.0162249281466827 0.347403328799946 1217 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque microtubule nucleation|mitotic spindle organization in nucleus structural constituent of cytoskeleton outer plaque of spindle pole body|gamma-tubulin small complex, spindle pole body|inner plaque of spindle pole body
YPR145W ASN1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0162101734046484 0.347842018407545 1218 Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication asparagine biosynthetic process asparagine synthase (glutamine-hydrolyzing) activity cytoplasm
YLR266C PDR8 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0161276027918233 0.350303511533612 1219 Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to stress RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding nucleus
YCR020W-B HTL1 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|RSC COMPLEX 0.0161255477026488 0.351012222813621 1220 Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance regulation of cell cycle|nucleosome disassembly|response to DNA damage stimulus|chromatin remodeling|transcription elongation from RNA polymerase II promoter chromatin binding RSC complex
YBL093C ROX3 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0160829240508619 0.351999301643997 1221 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme negative regulation of transcription from RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex|nucleus
YGL048C RPT6 het FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS 0.0160686978665041 0.352066244653698 1222 ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|nucleotide-excision repair|proteasome regulatory particle assembly|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of sequence-specific DNA binding transcription factor activity|chromatin remodeling ATPase activity|protein domain specific binding proteasome regulatory particle, base subcomplex|proteasome storage granule|nucleus
YOR232W MGE1 het FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0160487812865746 0.352878969080385 1223 Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE protein refolding|protein import into mitochondrial matrix adenyl-nucleotide exchange factor activity mitochondrion|presequence translocase-associated import motor|mitochondrial matrix
YDR162C NBP2 hom FF|FT PROTEIN PHOSPHORYLATION|NUCLEUS 0.0160361546052667 0.353689331982223 1224 Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM) negative regulation of protein kinase activity|response to heat|hyperosmotic response molecular_function nucleus|cytoplasm
YOR109W INP53 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|CYTOSKELETON 0.0160269235551585 0.353319739158279 1225 Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity membrane|actin cortical patch|cytoplasm
YDR234W LYS4 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION 0.0160242486684218 0.353400098713593 1226 Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway lysine biosynthetic process via aminoadipic acid homoaconitate hydratase activity mitochondrion
YIR039C YPS6 hom FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS|PLASMA MEMBRANE 0.015977307317296 0.354812200984848 1227 Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance fungal-type cell wall organization aspartic-type endopeptidase activity fungal-type cell wall
YIL047C SYG1 hom FT SIGNALING|MITOCHONDRION|PLASMA MEMBRANE 0.0159752540179509 0.354874050056273 1228 Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency signal transduction molecular_function mitochondrion|integral to membrane|plasma membrane
YKR080W MTD1 hom FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.0159268869743592 0.356332919573871 1229 NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline folic acid-containing compound biosynthetic process|one-carbon metabolic process|purine nucleobase biosynthetic process methylenetetrahydrofolate dehydrogenase (NAD+) activity cytosol
YMR029C FAR8 hom FT CELL CYCLE|SIGNALING|ENDOPLASMIC RETICULUM 0.0159228119949721 0.356456003367443 1230 Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p re-entry into mitotic cell cycle after pheromone arrest molecular_function cellular_component
YPL179W PPQ1 hom FT TRANSLATION 0.0159099240792388 0.356845456107341 1231 Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors protein dephosphorylation|regulation of translation protein serine/threonine phosphatase activity cytoplasm
YDR291W HRQ1 hom FT NUCLEUS 0.0158895654509008 0.359043045624502 1232 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS) biological_process molecular_function nucleus
YLR322W_d VPS65 hom 0.0158852048714247 0.359174951490212 1233 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth Unknown Unknown Unknown
YKR047W_d YKR047W hom 0.0158812072853454 0.357714196120717 1234 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 Unknown Unknown Unknown
YGL255W ZRT1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0158736231487425 0.358302463927978 1235 High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor high-affinity zinc ion transport high affinity zinc uptake transmembrane transporter activity integral to membrane|integral to plasma membrane
YDR179W-A_p YDR179W-A hom 0.015871614857857 0.358004682309889 1236 Putative protein of unknown function biological_process molecular_function cellular_component
YER078C ICP55 hom FT PROTEOLYSIS|NUCLEUS|MITOCHONDRION 0.0158593176078829 0.358592372153628 1237 Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family protein stabilization|protein processing aminopeptidase activity extrinsic to mitochondrial inner membrane|mitochondrion|nucleus
YLR120C YPS1 hom FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS|PLASMA MEMBRANE 0.015855416617134 0.358495548143637 1238 Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization|protein processing aspartic-type endopeptidase activity fungal-type cell wall
YOR356W CIR2 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.015847624463044 0.359018604852018 1239 Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response biological_process molecular_function mitochondrion
YNL336W COS1 hom 0.015775029891461 0.36093781464867 1240 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function integral to membrane|fungal-type vacuole
YPR072W NOT5 hom FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS 0.0157694142584013 0.361108814770633 1241 Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination ubiquitin-protein ligase activity CCR4-NOT core complex|cytoplasm
YJL023C PET130 hom FT MITOCHONDRION 0.0157682255950392 0.361145016948773 1242 Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YDL119C_p YDL119C hom FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION 0.0157429766567223 0.361914541237434 1243 Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria transport transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YOR307C SLY41 hom FT VESICLE-MEDIATED TRANSPORT|ENDOPLASMIC RETICULUM 0.0157394989423991 0.362307067336198 1244 Protein involved in ER-to-Golgi transport ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum
YMR144W_p YMR144W hom FT NUCLEUS 0.01573594686904 0.362128974179657 1245 Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene biological_process molecular_function nucleus
YOR321W PMT3 hom FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0157292613615251 0.362332979178879 1246 Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication protein O-linked glycosylation|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YJL173C RFA3 het FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0157049596790972 0.363075139145961 1247 Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress establishment of protein localization|telomere maintenance via telomerase|telomere maintenance via recombination|nucleotide-excision repair|DNA repair|mitotic recombination|heteroduplex formation|DNA unwinding involved in replication|reciprocal meiotic recombination|double-strand break repair via homologous recombination|DNA replication|protein ubiquitination double-stranded DNA binding|sequence-specific DNA binding condensed nuclear chromosome|chromosome, telomeric region|DNA replication factor A complex
YPL229W_p YPL229W hom 0.0156930648505928 0.363438747061715 1248 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YHL016C DUR3 hom FT PLASMA MEMBRANE 0.0156903711483427 0.363521121305308 1249 Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway urea transport|spermidine transport|putrescine transport|urea catabolic process urea transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity integral to membrane|plasma membrane
YDR283C GCN2 hom FF|FT KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION|RIBOSOME 0.0156843911059295 0.36391871561332 1250 Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control cellular amino acid biosynthetic process|protein phosphorylation|regulation of translational initiation|DNA damage checkpoint protein homodimerization activity|protein kinase activity|eukaryotic translation initiation factor 2alpha kinase activity cytosolic ribosome
YLR171W_d YLR171W hom 0.0156608634666009 0.36485366300076 1251 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL195W APL5 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0156505449367822 0.364740381141873 1252 Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function vesicle-mediated transport|Golgi to vacuole transport protein binding AP-3 adaptor complex
YGR265W_d YGR265W het 0.0156256655351877 0.365503346245312 1253 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase Unknown Unknown Unknown
YNL137C NAM9 het FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0156236363582385 0.365565617971487 1254 Mitochondrial ribosomal component of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YBR021W FUR4 hom FF|FT PLASMA MEMBRANE 0.0156086320483888 0.366383866363586 1255 Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation uracil transport|transmembrane transport uracil:cation symporter activity integral to membrane|membrane raft|plasma membrane
YOR385W_p YOR385W hom 0.01559567352145 0.366424420307588 1256 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene biological_process molecular_function cytoplasm
YDL088C ASM4 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0155894032365856 0.366617167519409 1257 FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication nuclear pore organization|mRNA export from nucleus in response to heat stress|mitotic cell cycle spindle assembly checkpoint nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding nuclear pore central transport channel|integral to membrane|nuclear pore
YKR088C TVP38 hom FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CYTOSKELETON ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0155781853954625 0.36696215917441 1258 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern vesicle-mediated transport|mitotic spindle elongation molecular_function integral to membrane|integral to Golgi membrane|cytoplasm
YHR030C SLT2 hom FF|FT PROTEIN LOCALIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION|NUCLEUS|SITE OF POLARIZED GROWTH 0.0155768360849734 0.368580090244219 1259 Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway protein phosphorylation|endoplasmic reticulum unfolded protein response|signal transduction|UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|regulation of transcription factor import into nucleus|barrier septum assembly|response to acid|regulation of cell size MAP kinase activity|protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm|cellular bud tip
YAL023C PMT2 hom FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0155133957763747 0.368958643946377 1260 Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication ER-associated misfolded protein catabolic process|protein O-linked glycosylation|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YKL139W CTK1 hom FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0154605297493412 0.370592697891022 1261 Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13 mRNA 3'-end processing|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of translational fidelity|positive regulation of transcription from RNA polymerase I promoter|peptidyl-serine phosphorylation|positive regulation of DNA-dependent transcription, elongation|protein phosphorylation protein kinase activity|cyclin-dependent protein kinase activity nucleoplasm|nucleolus|nucleus|polysome|carboxy-terminal domain protein kinase complex
YJR009C TDH2 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0154567625320899 0.370709311272536 1262 Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; TDH2 has a paralog, TDH3, that arose from the whole genome duplication gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YOL107W_p YOL107W hom FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0153939275650498 0.372657710036062 1263 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein biological_process molecular_function COPI-coated vesicle|Golgi apparatus
YJL014W CCT3 het FF 0.0153920702234893 0.373000653876062 1264 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo protein folding unfolded protein binding chaperonin-containing T-complex
YIL073C SPO22 hom FT CELL CYCLE|NUCLEUS|CHROMOSOME 0.0153879404517281 0.373414473372242 1265 Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis regulation of synaptonemal complex assembly molecular_function condensed nuclear chromosome
YBR221W-A_p YBR221W-A hom 0.0153456866241 0.37422910982825 1266 Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YJL198W PHO90 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS 0.0153381933513041 0.374391224082625 1267 Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication phosphate ion transport phosphate ion transmembrane transporter activity integral to membrane|membrane
YBR103W SIF2 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0153277109867823 0.374717815498393 1268 WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus negative regulation of meiosis|negative regulation of chromatin silencing at telomere|regulation of transcription, DNA-dependent|histone deacetylation|positive regulation of stress-activated MAPK cascade molecular_function Rpd3L-Expanded complex|nucleus|Set3 complex
YCR050C_p YCR050C hom 0.0153211992792196 0.374992000913078 1269 Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein biological_process molecular_function cellular_component
YPR108W-A_p YPR108W-A hom 0.0153204026222151 0.375159324383056 1270 Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YHR104W GRE3 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS|NUCLEUS 0.0152902503171314 0.375886388378448 1271 Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress galactose catabolic process|cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process|response to stress D-xylose:NADP reductase activity|mRNA binding|glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity nucleus|cytoplasm
YOR089C VPS21 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT|MITOCHONDRION 0.0152470209956095 0.37723770412712 1272 Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication endocytosis|vacuole inheritance|protein targeting to vacuole GTP binding|GTPase activity mitochondrial outer membrane|late endosome|mitochondrion
YNR048W YNR048W hom 0.0152386009143951 0.377501257383746 1273 Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication response to drug phospholipid-translocating ATPase activity integral to membrane
YNR009W NRM1 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS 0.0152331342420431 0.377672428004222 1274 Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase negative regulation of transcription involved in G1 phase of mitotic cell cycle repressing transcription factor binding|transcription factor binding transcription factor activity MBF transcription complex|nucleus|cytoplasm
YLR287C-A RPS30A hom FT TRANSLATION|RIBOSOME 0.0152289769942203 0.377802630356484 1275 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit|cytoplasmic stress granule
YDL070W BDF2 hom FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS 0.0152080066160547 0.378744347081406 1276 Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress negative regulation of heterochromatin assembly histone acetyl-lysine binding|core promoter binding|histone binding|TFIID-class transcription factor binding nucleus
YKL192C ACP1 het FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.0151982480180671 0.378765899441612 1277 Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p lipoate biosynthetic process ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process mitochondrion
YER163C GCG1 hom FT NUCLEUS 0.0151819261445891 0.379633713922892 1278 Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle biological_process molecular_function nucleus|cytoplasm
YNL071W LAT1 hom FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.0151657308848274 0.379786866147041 1279 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA acetyl-CoA biosynthetic process from pyruvate dihydrolipoyllysine-residue acetyltransferase activity mitochondrion|mitochondrial pyruvate dehydrogenase complex
YDR240C SNU56 het FT RNA PROCESSING|NUCLEUS 0.0151655573891604 0.379792318062556 1280 Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex mRNA splicing, via spliceosome mRNA binding commitment complex|U1 snRNP|U2-type prespliceosome
YGR229C SMI1 hom FF|FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|NUCLEUS|SITE OF POLARIZED GROWTH 0.0151566489291327 0.380072321511148 1281 Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity regulation of mitotic cell cycle|regulation of fungal-type cell wall biogenesis molecular_function incipient cellular bud site|cellular bud neck|mating projection tip
YLL018C-A COX19 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION 0.0151380403181113 0.380728647358673 1282 Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs mitochondrial respiratory chain complex IV assembly|metal ion transport copper ion binding|copper chaperone activity cytosol|mitochondrial intermembrane space
YDR226W ADK1 hom FT NUCLEOTIDE METABOLISM|MITOCHONDRION 0.0151294112703599 0.380929219752968 1283 Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress ADP biosynthetic process|DNA replication initiation|nucleotide metabolic process adenylate kinase activity mitochondrion|mitochondrial intermembrane space|cytoplasm
YHR199C AIM46 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION 0.0151088677447147 0.381576303992401 1284 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YNL232W CSL4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0151081005104764 0.381742489024911 1285 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1) nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing molecular_function nucleus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|cytoplasm
YGR129W SYF2 hom FT RNA PROCESSING|NUCLEUS 0.0150854159277195 0.38231581775378 1286 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest mRNA splicing, via spliceosome first spliceosomal transesterification activity|second spliceosomal transesterification activity U2-type post-mRNA release spliceosomal complex|Prp19 complex|U2-type prespliceosome|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YIL019W FAF1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0150568925731981 0.383287373081482 1287 Protein required for pre-rRNA processing and 40S ribosomal subunit assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus|nucleus|cytoplasm
YNR025C_d YNR025C hom 0.0150402760359727 0.383812616260955 1288 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase Unknown Unknown Unknown
YDL118W_d YDL118W hom FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS 0.0150293868071429 0.384086154916353 1289 Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein biological_process molecular_function cellular_component
YOL134C_d YOL134C het 0.0150163635208892 0.384498365296512 1290 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit Unknown Unknown Unknown
YGR076C MRPL25 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0150062508981613 0.384818634433939 1291 Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YJR123W RPS5 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME 0.0149955471541158 0.385157802082318 1292 Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7 cytoplasmic translation|rRNA export from nucleus|regulation of translational fidelity structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YKR039W GAP1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|PLASMA MEMBRANE 0.0149474198200726 0.386685059899775 1293 General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth amino acid transport|gamma-aminobutyric acid transport|ammonia assimilation cycle|polyamine transport amino acid transmembrane transporter activity|polyamine transmembrane transporter activity|L-proline transmembrane transporter activity endosome|fungal-type vacuole lumen|integral to membrane|plasma membrane|ER to Golgi transport vesicle|integral to plasma membrane|multivesicular body
YGL226W MTC3 hom FT MITOCHONDRION 0.0149379135174253 0.386987166222775 1294 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1 biological_process molecular_function mitochondrion
YIL137C TMA108 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS 0.0149002537933891 0.388539338083596 1295 Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease ribosome biogenesis molecular_function ribosome|cytoplasm
YDR357C_p CNL1 hom 0.0148989201578826 0.388298615124398 1296 Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function BLOC-1 complex|cytoplasm
YBR208C DUR1,2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.0148923140101479 0.388438299271834 1297 Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress allantoin catabolic process|urea catabolic process urea carboxylase activity|allophanate hydrolase activity cytoplasm
YNL241C ZWF1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS 0.0148892282658089 0.388536617781661 1298 Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress NADPH regeneration|response to hydrogen peroxide|pentose-phosphate shunt, oxidative branch|carbon catabolite repression of transcription glucose-6-phosphate dehydrogenase activity cytoplasm
YER015W FAA2 hom FT KETONE METABOLISM|LIPID METABOLISM|MITOCHONDRION 0.0148677843122281 0.389220286983939 1299 Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome long-chain fatty acid metabolic process long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|medium-chain fatty acid-CoA ligase activity mitochondrion|peroxisome
YML014W TRM9 hom FT RNA PROCESSING|NUCLEUS 0.0147812324347085 0.391987134590258 1300 tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses chronological cell aging|tRNA methylation|tRNA wobble uridine modification|response to stress tRNA (uracil) methyltransferase activity nucleus|cytoplasm
YHR176W FMO1 hom FT OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0147676288472869 0.392423089372682 1301 Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins protein folding N,N-dimethylaniline monooxygenase activity endoplasmic reticulum membrane
YNR059W MNT4 hom FT CARBOHYDRATE METABOLISM 0.0147450224317009 0.393218765745697 1302 Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation protein O-linked glycosylation alpha-1,3-mannosyltransferase activity cellular_component
YOR278W HEM4 het FT COFACTOR METABOLISM 0.0147433941367336 0.393200467944222 1303 Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria heme biosynthetic process uroporphyrinogen-III synthase activity cellular_component
YER182W_p FMP10 hom FT MITOCHONDRION 0.0147141281660341 0.394140476635694 1304 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YIL133C RPL16A hom FT TRANSLATION|RIBOSOME 0.0146966479313228 0.394702581144642 1305 Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YCL039W GID7 hom FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS 0.0146953372293185 0.395026828589308 1306 Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process molecular_function nucleus|GID complex|cytoplasm
YGR062C COX18 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0146787985024007 0.395277057486509 1307 Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC protein insertion into mitochondrial membrane from inner side membrane insertase activity integral to membrane|integral to mitochondrial inner membrane
YKL153W_d YKL153W het 0.014664864973594 0.395725853118104 1308 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant Unknown Unknown Unknown
YJL090C DPB11 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|CHROMOSOME 0.0146536158114272 0.396088410336131 1309 DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress lagging strand elongation|recombinational repair|nucleotide-excision repair|DNA replication initiation|mismatch repair|positive regulation of protein phosphorylation|mating type switching|DNA replication checkpoint|double-strand break repair via break-induced replication|mitotic cell cycle G2/M transition DNA damage checkpoint|leading strand elongation protein kinase activator activity|protein binding DNA replication preinitiation complex|replication fork|epsilon DNA polymerase complex
YOR259C RPT4 het FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS 0.0146528524753214 0.396183455850922 1310 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization ER-associated protein catabolic process|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription elongation from RNA polymerase II promoter|nucleotide-excision repair|proteasome regulatory particle assembly ATPase activity|protein domain specific binding proteasome regulatory particle, base subcomplex|nucleus
YOL029C_p YOL029C hom 0.0146395159604345 0.396543127469588 1311 Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens biological_process molecular_function cellular_component
YDR378C LSM6 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0146216096945059 0.397966971831817 1312 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasmic mRNA processing body
YLR335W NUP2 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CHROMOSOME|NUCLEAR PORE 0.0145962384609575 0.398011142094253 1313 Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization rRNA export from nucleus|snRNA export from nucleus|nuclear pore organization|tRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA-binding (hnRNP) protein import into nucleus|ribosomal protein import into nucleus|snRNP protein import into nucleus|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|protein targeting to membrane|poly(A)+ mRNA export from nucleus|protein export from nucleus|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, non-stop decay nucleocytoplasmic transporter activity nuclear chromatin|mitochondrion|integral to membrane|nuclear pore
YMR312W ELP6 hom FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS 0.0145933660915839 0.398244770984945 1314 Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity protein urmylation|regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification ATPase activity|tRNA binding Elongator holoenzyme complex
YDR083W RRP8 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|CHROMOSOME 0.0145705657884564 0.398771287568974 1315 Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1 rRNA processing methyltransferase activity nucleolus
YOR365C_p YOR365C hom 0.0145698619794178 0.398864392873288 1316 Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YDL024C DIA3 hom 0.014566215639432 0.399475160135898 1317 Protein of unknown function, involved in invasive and pseudohyphal growth pseudohyphal growth|invasive growth in response to glucose limitation acid phosphatase activity fungal-type cell wall
YGL014W PUF4 hom FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|TRANSLATION|GENE SILENCING 0.014558320303848 0.399167793095026 1318 Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of translation|protein localization|negative regulation of chromatin silencing involved in replicative cell aging mRNA binding cytoplasm
YER156C_p YER156C hom FT NUCLEUS 0.0145566067515917 0.399223296368904 1319 Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1 biological_process molecular_function nucleus|cytoplasm
YDR150W NUM1 hom FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|MITOCHONDRION|SITE OF POLARIZED GROWTH 0.0144951692872488 0.401216368565879 1320 Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex mitochondrion inheritance|nuclear migration along microtubule|mitochondrial fission|microtubule cytoskeleton organization tubulin binding cell cortex|mitochondrion|cellular bud tip
YMR154C RIM13 hom FF|FT ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS 0.0144642097960193 0.402995853284503 1321 Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB protein processing cysteine-type endopeptidase activity cellular_component
YHR047C AAP1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS 0.0144637333159928 0.402238477710349 1322 Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication glycogen metabolic process|proteolysis aminopeptidase activity nucleus|cytoplasm
YCL004W PGS1 het FT LIPID METABOLISM|MITOCHONDRION 0.0144569735701146 0.40245846781743 1323 Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis cardiolipin biosynthetic process CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity mitochondrion
YKR013W PRY2 hom 0.0144506946453904 0.40266287459541 1324 Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication biological_process molecular_function extracellular region|fungal-type vacuole
YDR239C YDR239C hom 0.0144283841496293 0.4033896829671 1325 Protein of unknown function that may interact with ribosomes, based on co-purification experiments biological_process molecular_function ribosome|cytoplasm
YCR091W KIN82 hom FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION 0.0144211430914333 0.403625743425012 1326 Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p phospholipid translocation|protein phosphorylation|response to pheromone protein kinase activity cellular_component
YGL112C TAF6 het FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE 0.0144015774727018 0.404264001283883 1327 Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4 histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter chromatin binding|RNA polymerase II activating transcription factor binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YLR001C_p YLR001C hom FT MITOCHONDRION 0.0143911095761546 0.404886093985176 1328 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated biological_process molecular_function mitochondrion|fungal-type vacuole membrane
YER167W BCK2 hom FT CELL CYCLE|NUCLEUS 0.0143904522762188 0.404697254141347 1329 Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations regulation of cell cycle|positive regulation of gene expression|G1/S transition of mitotic cell cycle molecular_function nucleus|cytoplasm
YOR225W_d YOR225W hom 0.0142738143607829 0.408446632445046 1330 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL133C FYV6 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0142505965810938 0.409209478481563 1331 Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining double-strand break repair via nonhomologous end joining molecular_function nucleus
YKR090W PXL1 hom FT SIGNALING|SITE OF POLARIZED GROWTH 0.0142458217421098 0.409366466121618 1332 Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress maintenance of cell polarity|regulation of Rho protein signal transduction Rho GDP-dissociation inhibitor activity incipient cellular bud site|cellular bud|mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YCL001W RER1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0142367701966193 0.409664162022197 1333 Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER protein retention in ER lumen|retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport molecular_function COPI-coated vesicle|integral to membrane|ER to Golgi transport vesicle
YBR193C MED8 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.01418774185881 0.411278887877656 1334 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter TBP-class protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription corepressor activity|structural molecule activity core mediator complex
YJL193W_p YJL193W hom 0.0141607542489333 0.412518036733754 1335 Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect biological_process molecular_function integral to membrane
YMR246W FAA4 hom FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM 0.0141607419340476 0.412169728101748 1336 Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process long-chain fatty acid-CoA ligase activity lipid particle|cytoplasm
YLR229C CDC42 het FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0141433822820344 0.412743099050501 1337 Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins budding cell apical bud growth|Rho protein signal transduction|budding cell isotropic bud growth|regulation of initiation of mating projection growth|regulation of vacuole fusion, non-autophagic|regulation of exit from mitosis|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|establishment of cell polarity|invasive growth in response to glucose limitation|positive regulation of exocytosis GTPase activity|signal transducer activity nuclear membrane|fungal-type vacuole membrane|incipient cellular bud site|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YGL115W SNF4 hom FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE 0.0141343773854675 0.413180055663499 1338 Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress positive regulation of gluconeogenesis|peroxisome organization|protein phosphorylation|replicative cell aging|regulation of transcription from RNA polymerase II promoter AMP-activated protein kinase activity|protein serine/threonine kinase activator activity AMP-activated protein kinase complex|plasma membrane|nucleus|nuclear envelope lumen|cytoplasm
YJL050W MTR4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|OXIDATION-REDUCTION PROCESS|RNA LOCALIZATION|NUCLEUS 0.0141254285938555 0.413336587067203 1339 ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ATP-dependent 3'-5' RNA helicase activity|poly(A) RNA binding nucleolus|nucleus|TRAMP complex
YML110C COQ5 hom FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.0140689973627093 0.415205298186251 1340 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes ubiquinone biosynthetic process|aerobic respiration 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity mitochondrion|mitochondrial matrix
YBL013W FMT1 hom FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION 0.0140590763836239 0.41553434479393 1341 Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate translational initiation|methionyl-tRNA aminoacylation methionyl-tRNA formyltransferase activity mitochondrion
YDR440W DOT1 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS 0.0140527544566541 0.416509892162903 1342 Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response meiotic recombination checkpoint|postreplication repair|recombinational repair|global genome nucleotide-excision repair|nucleotide-excision repair|DNA damage checkpoint|chromatin silencing at telomere|histone H3-K79 methylation nucleosomal histone binding|histone methyltransferase activity (H3-K79 specific) nucleus
YGR178C PBP1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|NUCLEUS|MITOCHONDRION 0.0140346891560916 0.41634384389062 1343 Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress positive regulation of translation|mRNA polyadenylation|stress granule assembly molecular_function mitochondrion|nucleus|polysome|cytoplasmic stress granule|cytoplasm
YNL138W SRV2 hom FT SIGNALING|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0140207527416166 0.416806860581667 1344 CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis cytoskeleton organization|Ras protein signal transduction cytoskeletal protein binding|adenylate cyclase binding mating projection tip|actin cortical patch
YCL002C_p YCL002C hom 0.014015733736795 0.41697368388849 1345 Putative protein of unknown function; YCL002C is not an essential gene biological_process molecular_function integral to membrane
YNL319W_d YNL319W hom 0.0140142598325371 0.417022681469869 1346 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 Unknown Unknown Unknown
YOR074C CDC21 het FT NUCLEOTIDE METABOLISM|NUCLEUS 0.0140141117594092 0.417027604110918 1347 Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S dTMP biosynthetic process thymidylate synthase activity nucleus
YOL031C SIL1 hom FT PROTEIN LOCALIZATION|ENDOPLASMIC RETICULUM 0.0140124054324531 0.417223276073081 1348 Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein SRP-dependent cotranslational protein targeting to membrane, translocation adenyl-nucleotide exchange factor activity endoplasmic reticulum
YFL007W BLM10 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS 0.0139866829377868 0.417940056622205 1349 Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 proteasome assembly|regulation of proteasomal protein catabolic process proteasome binding|peptidase activator activity proteasome core complex|proteasome complex|integral to membrane|nucleus
YCL032W STE50 hom FT CELL CYCLE|SIGNALING 0.0139286814380209 0.420220179464201 1350 Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction pheromone-dependent signal transduction involved in conjugation with cellular fusion|MAPK cascade involved in osmosensory signaling pathway|osmosensory signaling pathway via Sho1 osmosensor|signal transduction involved in filamentous growth|cellular response to heat SAM domain binding|protein kinase regulator activity cytoplasm
YDL069C CBS1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0139173446263721 0.420667966584216 1351 Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation translation regulator activity extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial ribosome
YBR227C MCX1 hom FT MITOCHONDRION 0.0139106002541817 0.420477182029692 1352 Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins protein refolding molecular_function mitochondrion|mitochondrial matrix
YOL098C_p YOL098C hom FT PROTEOLYSIS 0.0138807336351908 0.4214756086116 1353 Putative metalloprotease biological_process molecular_function cytoplasm
YHR021C RPS27B hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.0138153145291567 0.423667388261914 1354 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YJR055W HIT1 hom FT NUCLEUS 0.0138042027721901 0.42404033395535 1355 Protein of unknown function, required for growth at high temperature biological_process molecular_function nucleus|cytoplasm
YDL095W PMT1 hom FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0137755325448906 0.425418015640719 1356 Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen ER-associated misfolded protein catabolic process|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YBR266C_d SLM6 hom 0.013707122146964 0.427306820144753 1357 Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase Unknown Unknown Unknown
YBR203W COS111 hom FT SIGNALING|MITOCHONDRION 0.0136933796679374 0.427977131437917 1358 Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies signal transduction molecular_function mitochondrion
YIL072W HOP1 hom FT CELL CYCLE|NUCLEUS|CHROMOSOME 0.0136930931348418 0.427780065105501 1359 Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments synaptonemal complex assembly|meiotic recombination checkpoint|synapsis four-way junction DNA binding condensed nuclear chromosome|lateral element
YMR159C ATG16 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.0136818650104472 0.428159046526675 1360 Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway protein binding, bridging|Atg8 ligase activity Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YBR285W_p YBR285W hom 0.0136711472576598 0.428520983571576 1361 Putative protein of unknown function; YBR285W is not an essential gene biological_process molecular_function cellular_component
YNL179C_d YNL179C hom 0.0136566236841398 0.429011726431928 1362 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YDR536W STL1 hom FT PLASMA MEMBRANE 0.0136399215814717 0.429576484039068 1363 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock transport|glycerol transport|transmembrane transport solute:hydrogen symporter activity|transporter activity integral to membrane|plasma membrane|membrane
YER005W YND1 hom FT LIPID METABOLISM|CARBOHYDRATE METABOLISM|GOLGI APPARATUS 0.0136359896658977 0.429709498872583 1364 Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity protein glycosylation nucleoside-triphosphatase activity|nucleoside-diphosphatase activity COPI-coated vesicle|Golgi apparatus|membrane|Golgi membrane
YDR448W ADA2 hom FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.0136112901266896 0.430545619330818 1365 Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes chromatin silencing at rDNA|chromatin modification|regulation of transcription from RNA polymerase II promoter|positive regulation of histone acetylation|chromatin silencing at telomere chromatin binding|transcription coactivator activity|histone acetyltransferase activity|phosphatidylserine binding SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YJL117W PHO86 hom FT VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOPLASMIC RETICULUM 0.0135852596252617 0.431427815590947 1366 Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress protein folding|ER to Golgi vesicle-mediated transport|regulation of phosphate transport unfolded protein binding endoplasmic reticulum
YPR089W_p YPR089W hom FT GOLGI APPARATUS 0.0135288279415846 0.433343926931468 1367 Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p biological_process molecular_function cellular_component
YJL008C CCT8 het 0.0135194829959352 0.433661704320218 1368 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo protein folding unfolded protein binding chaperonin-containing T-complex|cytoplasm
YNL220W ADE12 hom FT NUCLEOTIDE METABOLISM 0.0134678089351565 0.435421324125492 1369 Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence purine nucleotide biosynthetic process DNA replication origin binding|adenylosuccinate synthase activity cytoplasm
YMR052C-A_d YMR052C-A hom 0.0134487403491811 0.436071691614843 1370 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR087C CSF1 hom FF|FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0134448599017873 0.436409400189286 1371 Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies fermentation molecular_function mitochondrion
YHR161C YAP1801 hom FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON 0.0134446188417402 0.436212336370742 1372 Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication endocytosis clathrin binding actin cortical patch
YNL110C NOP15 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS 0.0133858009209022 0.4384955955028 1373 Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm cytokinesis, actomyosin contractile ring assembly|ribosomal large subunit biogenesis molecular_function nucleolus|nucleus|preribosome, large subunit precursor
YPR085C ASA1 het FT CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME 0.0133856307745864 0.438228141805653 1374 Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 biological_process molecular_function ASTRA complex
YJL063C MRPL8 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0133144347702913 0.440668245939664 1375 Mitochondrial ribosomal protein of the large subunit mitochondrial genome maintenance|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YJL128C PBS2 hom FF|FT PROTEIN LOCALIZATION|SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH 0.0132654326429212 0.442352211887186 1376 MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition activation of MAPK activity involved in osmosensory signaling pathway|actin filament organization|MAPK import into nucleus involved in osmosensory signaling pathway|protein phosphorylation|hyperosmotic response|osmosensory signaling pathway|cellular response to heat MAP-kinase scaffold activity|MAP kinase kinase activity|protein kinase activity cellular bud neck|cytoplasm|cellular bud tip
YML018C YML018C hom 0.0132653596323705 0.44269511109092 1377 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YOR254C SEC63 het FT PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.0132512839324507 0.442839118364836 1378 Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation|cytosol to ER transport|SRP-dependent cotranslational protein targeting to membrane|posttranslational protein targeting to membrane protein transporter activity mitochondrion|integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YOR135C_d IRC14 hom 0.0132443608626391 0.44307747690387 1379 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci Unknown Unknown Unknown
YPR162C ORC4 het FT GENE SILENCING|NUCLEUS|CHROMOSOME 0.0132311712748103 0.443531791957622 1380 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing pre-replicative complex assembly|DNA replication initiation|chromatin silencing at silent mating-type cassette DNA replication origin binding DNA replication preinitiation complex|pre-replicative complex|nuclear origin of replication recognition complex
YMR209C_p YMR209C hom 0.0132255594572757 0.443725171521462 1381 Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity cellular_component
YDL226C GCS1 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|MITOCHONDRION|GOLGI APPARATUS|CYTOSKELETON 0.013195184497612 0.444772707746485 1382 ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p retrograde vesicle-mediated transport, Golgi to ER|Golgi to plasma membrane protein transport|actin filament reorganization involved in cell cycle|ER to Golgi vesicle-mediated transport actin binding|ARF GTPase activator activity|GTPase activator activity endosome|trans-Golgi network|endoplasmic reticulum-Golgi intermediate compartment|cytoskeleton
YFL017C GNA1 het FT CARBOHYDRATE METABOLISM|NUCLEUS 0.0131703300733498 0.445630906052107 1383 Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA UDP-N-acetylglucosamine biosynthetic process glucosamine 6-phosphate N-acetyltransferase activity nucleus|cytoplasm
YDR361C BCP1 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.0131633908759517 0.446074209596004 1384 Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport protein export from nucleus|ribosomal large subunit export from nucleus molecular_function nucleus|cytoplasm
YHR196W UTP9 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|CHROMOSOME 0.0131588256908145 0.44602845990813 1385 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) snoRNA binding small-subunit processome|rDNA heterochromatin|nucleolus|t-UTP complex|nucleus|90S preribosome
YPL272C_p YPL272C hom 0.0131313471489799 0.44731779687817 1386 Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene biological_process molecular_function cellular_component
YHR200W RPN10 hom FT PROTEOLYSIS 0.0130919797940606 0.448342426472103 1387 Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein ubiquitin-dependent protein catabolic process structural molecule activity|polyubiquitin binding proteasome complex|proteasome regulatory particle, base subcomplex
YDL115C IWR1 hom FT PROTEIN LOCALIZATION|NUCLEUS|RNA POL II, HOLOENZYME 0.0130842809185893 0.448609370999497 1388 RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress cellular protein complex localization|nucleocytoplasmic transport protein binding nucleus|DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YPL049C DIG1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0130804210217667 0.448743239849837 1389 MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown DNA binding|transcription factor binding nucleus
YPR097W YPR097W hom FT MITOCHONDRION 0.0130654647708953 0.449262166187891 1390 Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process phosphatidylinositol binding mitochondrion
YLR284C ECI1 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS 0.0130644858903703 0.449431380788221 1391 Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced fatty acid beta-oxidation dodecenoyl-CoA delta-isomerase activity peroxisome
YGL003C CDH1 hom FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.0130640918813011 0.44944505487876 1392 Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p activation of mitotic anaphase-promoting complex activity|negative regulation of spindle pole body separation|positive regulation of mitotic metaphase/anaphase transition|Unknown|regulation of cell size anaphase-promoting complex binding|cyclin binding|ubiquitin-protein ligase activator activity nucleus|anaphase-promoting complex|cytoplasm
YBL069W AST1 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|GOLGI APPARATUS|PLASMA MEMBRANE 0.0130089847741162 0.451224877823675 1393 Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication protein targeting to membrane|protein transport into membrane raft molecular_function late endosome|membrane raft|Golgi apparatus|plasma membrane
YDR060W MAK21 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.0129998268154291 0.451543578355443 1394 Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein ribosomal large subunit assembly molecular_function Noc1p-Noc2p complex
YGL234W ADE5,7 hom FT NUCLEOTIDE METABOLISM 0.0129857946179812 0.452032151105211 1395 Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities purine nucleobase metabolic process|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity cytoplasm
YKR026C GCN3 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION 0.0129807175426906 0.452208998165722 1396 Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression regulation of translational initiation enzyme regulator activity|guanyl-nucleotide exchange factor activity|translation initiation factor activity eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YER150W SPI1 hom 0.012933725331507 0.454117070978869 1397 GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p response to acid molecular_function fungal-type cell wall
YIL153W RRD1 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION|NUCLEUS|CHROMOSOME 0.0129085696670812 0.454726306895033 1398 Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress DNA repair|mitotic spindle organization in nucleus|G1/S transition of mitotic cell cycle|response to osmotic stress|regulation of transcription from RNA polymerase II promoter in response to stress peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity nuclear chromatin|nucleus|cytoplasm
YIL065C FIS1 hom FT MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION|MITOCHONDRION 0.0129039606782172 0.454887386661512 1399 Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization molecular_function mitochondrial outer membrane|mitochondrion|peroxisome
YJR051W OSM1 hom FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.0128878101295653 0.455519298424642 1400 Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication cellular response to anoxia fumarate reductase (NADH) activity mitochondrion
YKR062W TFA2 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0128813941066432 0.456012672424497 1401 TFIIE small subunit, involved in RNA polymerase II transcription initiation transcription from RNA polymerase II promoter single-stranded DNA binding|RNA polymerase II core binding|TFIIH-class transcription factor binding transcription factor TFIIE complex
YHR064C SSZ1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION 0.0128695854987894 0.456089779230785 1402 Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP cytoplasmic translation|regulation of translational fidelity|rRNA processing unfolded protein binding polysome|cytoplasm
YGR184C UBR1 hom FT PROTEOLYSIS 0.0128571324610305 0.457265215369562 1403 E3 ubiquitin ligase (N-recognin); forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; plays a major role in targeting cytosolic misfolded proteins for degradation; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS) regulation of dipeptide transport|ubiquitin-dependent protein catabolic process via the N-end rule pathway|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination ubiquitin-protein ligase activity proteasome regulatory particle, base subcomplex|cytoplasm
YOR330C MIP1 hom FT MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0128444640403946 0.457305331551177 1404 Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit mitochondrial DNA replication 3'-5' exonuclease activity|DNA-directed DNA polymerase activity mitochondrion
YBR245C ISW1 hom FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0128393981930619 0.457147158052339 1405 ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions termination of RNA polymerase I transcription|nucleosome positioning|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|regulation of transcriptional start site selection at RNA polymerase II promoter|heterochromatin maintenance involved in chromatin silencing|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter nucleosome binding|ATPase activity|rDNA binding|DNA binding ISW1 complex|nucleolar chromatin
YNR020C ATP23 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0128086911958551 0.458224150801097 1406 Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p protein processing|mitochondrial proton-transporting ATP synthase complex assembly metalloendopeptidase activity mitochondrial inner membrane|mitochondrial intermembrane space
YBR200W-A_p YBR200W-A hom 0.0128073044492761 0.458272821994377 1407 Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YKR067W GPT2 hom FT LIPID METABOLISM|ENDOPLASMIC RETICULUM 0.0127880492178476 0.458948929902317 1408 Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen phospholipid biosynthetic process glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity integral to membrane|lipid particle|endoplasmic reticulum|cytoplasm
YPL057C SUR1 hom FT LIPID METABOLISM 0.0127808494391322 0.459201878790763 1409 Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication glycosphingolipid biosynthetic process|mannosyl-inositol phosphorylceramide metabolic process|sphingolipid biosynthetic process mannosyltransferase activity|transferase activity, transferring glycosyl groups integral to membrane|intracellular
YOR027W STI1 hom 0.0127805629711575 0.459211944847413 1410 Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop protein folding Hsp70 protein binding|Hsp90 protein binding|mRNA binding|ATPase inhibitor activity cytoplasm
YDR222W_p YDR222W hom FT RESPONSE TO OXIDATIVE STRESS 0.0127694073065358 0.459604034314618 1411 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YIL078W THS1 het FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION 0.0127524567962533 0.460200154388338 1412 Threonyl-tRNA synthetase, essential cytoplasmic protein cytoplasmic translation|threonyl-tRNA aminoacylation threonine-tRNA ligase activity mitochondrion|cytoplasm
YLR166C SEC10 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH 0.0127484637279071 0.460340646585639 1413 Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion exocytosis|establishment of cell polarity|Golgi to plasma membrane transport|vesicle fusion|vesicle docking involved in exocytosis molecular_function mating projection tip|exocyst
YKR011C YKR011C hom FT NUCLEUS 0.0126904771232245 0.462383549188438 1414 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YGR143W SKN1 hom FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 0.0126871079641947 0.462502401884355 1415 Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process|sphingolipid biosynthetic process glucosidase activity integral to membrane
YOR213C SAS5 hom FT CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME|HISTONE ACETYLTRANSFERASE 0.0126682612469388 0.463167565305578 1416 Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity chromatin silencing at telomere acetyltransferase activity|histone acetyltransferase activity nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YER110C KAP123 hom FT PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.01263310056326 0.464743107069305 1417 Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 NLS-bearing substrate import into nucleus|Unknown|protein import into nucleus|ribosomal protein import into nucleus protein transporter activity|nuclear localization sequence binding integral to membrane|nucleus|nuclear pore|cytoplasm
YGL034C_d YGL034C hom 0.0125611323870498 0.46695860722335 1418 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIR019C FLO11 hom FT SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.0125464690134831 0.467478845244995 1419 GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain cell-cell adhesion|biofilm formation|pseudohyphal growth|filamentous growth|flocculation|invasive growth in response to glucose limitation molecular_function extracellular region|plasma membrane|cellular bud neck
YDR113C PDS1 het FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CYTOSKELETON 0.012543960813092 0.467833495775874 1420 Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation protein localization|recombinational repair|meiosis I|mitotic sister chromatid segregation enzyme binding nucleus|cytoplasm|spindle
YGR219W_d YGR219W hom 0.0125134535379743 0.46871767580296 1421 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C Unknown Unknown Unknown
YPR127W YPR127W hom FT OXIDATION-REDUCTION PROCESS|NUCLEUS 0.0125087760865791 0.468817615353385 1422 Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YDL079C MRK1 hom FT PROTEIN PHOSPHORYLATION 0.0124980555195591 0.469198773356593 1423 Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation regulation of protein catabolic process|protein phosphorylation|response to stress protein serine/threonine kinase activity cellular_component
YAL040C CLN3 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS 0.0124807708242191 0.469879898227751 1424 G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis vacuole organization|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|vacuole fusion, non-autophagic|regulation of cell size|G1/S transition of mitotic cell cycle cyclin-dependent protein kinase regulator activity nucleus
YDR316W OMS1 hom FT MITOCHONDRION 0.0124299783537895 0.4716892723614 1425 Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations biological_process S-adenosylmethionine-dependent methyltransferase activity mitochondrial envelope|mitochondrion
YEL017C-A PMP2 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0123887528354335 0.473689121878039 1426 Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication cation transport molecular_function membrane
YPL025C_d YPL025C hom 0.0123664040096525 0.473893441108192 1427 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YML072C TCB3 hom FT ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE 0.0123552469246377 0.474292483509537 1428 Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact biological_process lipid binding mitochondrion|cortical endoplasmic reticulum|cellular bud
YPL134C ODC1 hom FT MITOCHONDRION 0.0123533571499989 0.474360091136845 1429 Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation mitochondrial transport dicarboxylic acid transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YLR128W DCN1 hom 0.0123341998116551 0.475045753087203 1430 Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation protein neddylation|positive regulation of ubiquitin-protein ligase activity ubiquitin binding|NEDD8 ligase activity|small conjugating protein binding cellular_component
YHR171W ATG7 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|MITOCHONDRION 0.0122289222907939 0.478823436650958 1431 Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation C-terminal protein lipidation|protein modification by small protein conjugation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway APG8 activating enzyme activity|APG12 activating enzyme activity cytosol|mitochondrion|membrane|pre-autophagosomal structure
YKL078W DHR2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0122191297477731 0.479175655144609 1432 Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosome biogenesis RNA helicase activity nucleolus
YBR300C_d YBR300C hom 0.0121936105653463 0.480094193754541 1433 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene Unknown Unknown Unknown
YKL156W RPS27A hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.012151559709315 0.481675226790319 1434 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|cytoplasm
YGR281W YOR1 hom FT NUCLEOTIDE METABOLISM|PLASMA MEMBRANE 0.0121436320054211 0.481895900820171 1435 Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR) transport|response to drug xenobiotic-transporting ATPase activity integral to membrane|plasma membrane
YKR014C YPT52 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.0121042730832343 0.483317357469071 1436 Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress endocytosis|protein targeting to vacuole GTPase activity late endosome
YML015C TAF11 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.0120721892143064 0.4845428993253 1437 TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly transcription factor TFIID complex
YOR200W_d YOR200W hom 0.0120031904046795 0.486978383756431 1438 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c Unknown Unknown Unknown
YGL244W RTF1 hom FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING|NUCLEUS|CHROMOSOME|RNA POL II, HOLOENZYME 0.0119636001409539 0.488416339632532 1439 Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of chromatin silencing at telomere|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|negative regulation of transcription from RNA polymerase II promoter|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|global genome nucleotide-excision repair|snoRNA 3'-end processing|Unknown|transcription elongation from RNA polymerase II promoter RNA binding|RNA polymerase II transcription factor binding transcription factor activity nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YGR255C COQ6 hom FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM|MITOCHONDRION 0.0119618581615112 0.488479662489204 1440 Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS) ubiquinone biosynthetic process N,N-dimethylaniline monooxygenase activity mitochondrion|mitochondrial inner membrane
YHR146W CRP1 hom FT NUCLEUS 0.0119595290267377 0.488564335995377 1441 Protein that binds to cruciform DNA structures biological_process DNA binding nucleus
YOR042W CUE5 hom 0.0118984440188007 0.490787844863385 1442 Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process ubiquitin binding cytoplasm
YNL173C MDG1 hom FT SIGNALING|PLASMA MEMBRANE 0.0118973550934674 0.490827531260223 1443 Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations pheromone-dependent signal transduction involved in conjugation with cellular fusion molecular_function membrane raft|plasma membrane
YBR182C SMP1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.0118797766878714 0.491468422983277 1444 Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress DNA binding, bending|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YPL215W CBP3 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0118647001613812 0.492018456180676 1445 Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly ribosome binding integral to mitochondrial membrane|mitochondrion|mitochondrial ribosome
YOL124C TRM11 hom FT RNA PROCESSING 0.0118431278019822 0.492806049002595 1446 Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain tRNA methylation S-adenosylmethionine-dependent methyltransferase activity|RNA binding|tRNA (guanine-N2-)-methyltransferase activity cytoplasm|tRNA (m2G10) methyltransferase complex
YPR144C NOC4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0118258892799397 0.493435901385806 1447 Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits ribosomal small subunit biogenesis|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing molecular_function small-subunit processome|nucleolus|nucleus|90S preribosome|Noc4p-Nop14p complex
YDR404C RPB7 het FF|FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|TRANSLATION|NUCLEUS|RNA POL II, HOLOENZYME 0.011813619883776 0.494013295832497 1448 RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation transcription initiation from RNA polymerase II promoter|positive regulation of translational initiation|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|nuclear-transcribed mRNA catabolic process, exonucleolytic|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|translation initiation factor binding|single-stranded RNA binding|single-stranded DNA binding nucleus|DNA-directed RNA polymerase II, core complex|cytoplasmic mRNA processing body|cytoplasm
YKL143W LTV1 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS 0.0117802581473943 0.495105226236646 1449 Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature ribosomal small subunit biogenesis|cellular response to oxidative stress|response to osmotic stress|ribosomal small subunit export from nucleus molecular_function preribosome, small subunit precursor|EGO complex|nucleus|late endosome membrane|cytoplasm
YBL098W BNA4 hom FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|MITOCHONDRION 0.0117671901057923 0.495583849628168 1450 Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease de novo NAD biosynthetic process from tryptophan kynurenine 3-monooxygenase activity mitochondrial outer membrane|mitochondrion
YCR043C_p YCR043C hom FT GOLGI APPARATUS|SITE OF POLARIZED GROWTH 0.0117627491796266 0.495746556907406 1451 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene biological_process molecular_function Golgi apparatus|mating projection tip
YBR282W MRPL27 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0117303765856988 0.49693348919594 1452 Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YLR260W LCB5 hom FT LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0117174435718741 0.498242891477473 1453 Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules response to heat|calcium-mediated signaling|sphingolipid metabolic process D-erythro-sphingosine kinase activity Golgi apparatus|membrane
YLR373C VID22 hom FT PROTEIN LOCALIZATION|NUCLEUS|PLASMA MEMBRANE 0.0117043529579641 0.497888734768995 1454 Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles vacuolar protein catabolic process molecular_function integral to plasma membrane
YBR039W ATP3 hom FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION 0.0116657829402772 0.499306313635211 1455 Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthesis coupled proton transport proton-transporting ATPase activity, rotational mechanism mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YBR131W CCZ1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.0116596098775414 0.499533393366217 1456 Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway autophagy|autophagic vacuole fusion|vacuolar transport|vesicle docking|protein targeting to vacuole guanyl-nucleotide exchange factor activity Mon1-Ccz1 complex|membrane
YER185W PUG1 hom FT PLASMA MEMBRANE 0.0115980561543882 0.501800678078939 1457 Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins heme transport molecular_function integral to membrane|plasma membrane
YKL004W AUR1 het FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0115890586704707 0.502132549061291 1458 Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance inositolphosphoceramide metabolic process|sphingolipid biosynthetic process inositol phosphoceramide synthase activity integral to membrane|Golgi apparatus|inositol phosphoceramide synthase complex
YNL123W NMA111 hom FT LIPID METABOLISM|PROTEOLYSIS|NUCLEUS 0.0115329767732489 0.504203735929333 1459 Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases apoptotic process|cellular lipid metabolic process|protein catabolic process|cellular response to heat serine-type peptidase activity nucleus
YGR183C QCR9 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.0115211224060136 0.504896355844363 1460 Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex iron-sulfur cluster assembly|mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YPL154C PEP4 hom FT MEMBRANE ORGANIZATION|PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS|MITOCHONDRION 0.0115187752573282 0.504728932649647 1461 Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates microautophagy|proteolysis involved in cellular protein catabolic process|cellular response to starvation peptidase activity fungal-type vacuole lumen|mitochondrion|fungal-type vacuole
YMR205C PFK2 hom FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0115117680442624 0.505178754691324 1462 Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes proton transport|glycolysis mRNA binding|6-phosphofructokinase activity mitochondrion|6-phosphofructokinase complex|cytoplasm
YPL270W MDL2 hom FT NUCLEOTIDE METABOLISM|MITOCHONDRION 0.0114894640141571 0.505813824052183 1463 Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis oligopeptide transport|oligopeptide export from mitochondrion oligopeptide-transporting ATPase activity mitochondrion|integral to membrane|mitochondrial inner membrane
YDR127W ARO1 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 0.0114076765345383 0.510050412400657 1464 Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids aromatic amino acid family biosynthetic process shikimate kinase activity|shikimate 3-dehydrogenase (NADP+) activity|3-phosphoshikimate 1-carboxyvinyltransferase activity|3-dehydroquinate dehydratase activity|3-dehydroquinate synthase activity cytoplasm
YIL115C NUP159 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.0113962155622884 0.509273353712711 1465 FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p) poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|protein export from nucleus|ribosomal large subunit export from nucleus|ncRNA export from nucleus|nuclear pore distribution|ribosomal small subunit export from nucleus nucleocytoplasmic transporter activity|adenyl-nucleotide exchange factor activity nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YDR524W-C_p YDR524W-C hom 0.0113732746007749 0.510441906847951 1466 Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin biological_process molecular_function cellular_component
YMR316W DIA1 hom 0.0113157573542814 0.512268288385182 1467 Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern pseudohyphal growth|invasive growth in response to glucose limitation molecular_function cytoplasm
YCR023C YCR023C hom 0.0112614739234375 0.514482303925666 1468 Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YMR060C SAM37 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0112468060579032 0.514842181875226 1469 Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane|phospholipid transport molecular_function mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to membrane
YKR024C DBP7 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0112316017887808 0.515723938543666 1470 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ATP-dependent RNA helicase activity nucleolus
YJR066W TOR1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS|PLASMA MEMBRANE 0.0112185242598928 0.51589985650896 1471 PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication regulation of cell cycle|G1 phase of mitotic cell cycle|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell growth|response to DNA damage stimulus|mitochondria-nucleus signaling pathway|ribosome biogenesis|meiosis|signal transduction|TOR signaling cascade|fungal-type cell wall organization|negative regulation of autophagy protein binding|protein kinase activity TORC1 complex|fungal-type vacuole membrane|endosome membrane|extrinsic to internal side of plasma membrane|plasma membrane|nucleus|Golgi membrane|cytoplasm
YPR060C ARO7 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.0111882840088953 0.517032017985927 1472 Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis aromatic amino acid family biosynthetic process chorismate mutase activity nucleus|cytoplasm
YKR096W ESL2 hom FT NUCLEUS 0.0111289596247535 0.519506061479522 1473 Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain biological_process molecular_function ribosome|nucleus|cytoplasm
YML001W YPT7 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT|MITOCHONDRION 0.0111217393181513 0.519839405565508 1474 Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7 regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole inheritance|Golgi to vacuole transport|vesicle-mediated transport|endocytosis GTPase activity mitochondrial outer membrane|fungal-type vacuole
YKR074W AIM29 hom 0.0111082659517218 0.520345283266328 1475 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function cytoplasm
YNL103W MET4 het FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 0.0110885843283534 0.520773753705758 1476 Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p response to cadmium ion|sulfur amino acid metabolic process|response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter transcription coactivator activity nucleus
YFR009W GCN20 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEOTIDE METABOLISM|RIBOSOME 0.0110593441315852 0.522184256227141 1477 Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA regulation of translational elongation ATPase activity cytosol|cytosolic ribosome
YFR050C PRE4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0110356525535251 0.522951949185235 1478 Beta 7 subunit of the 20S proteasome proteasome assembly|proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YDL183C YDL183C hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION 0.0110269117391546 0.52340522907767 1479 Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene potassium ion transport|proton transport molecular_function integral to mitochondrial inner membrane
YJL080C SCP160 hom FT CELL CYCLE|SIGNALING|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.0109724933163124 0.525209939226589 1480 Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins meiotic telomere clustering|pheromone-dependent signal transduction involved in conjugation with cellular fusion|chromosome segregation|intracellular mRNA localization|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere G-protein alpha-subunit binding|RNA binding endoplasmic reticulum membrane|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YNL135C FPR1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION 0.0109112583074011 0.527647852526332 1481 Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function protein folding|chromatin organization|homoserine metabolic process peptidyl-prolyl cis-trans isomerase activity|macrolide binding mitochondrion|nucleus|cytoplasm
YGR116W SPT6 het FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RNA LOCALIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME 0.0108961251882424 0.528035988872823 1482 Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region poly(A)+ mRNA export from nucleus|regulation of transcription by chromatin organization|regulation of mRNA 3'-end processing|transcription antitermination|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|regulation of transcriptional start site selection at RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of transcription from RNA polymerase II promoter|nucleosome organization|chromatin maintenance|regulation of nucleosome density|nucleosome assembly|chromatin remodeling|regulation of histone H3-K36 methylation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to stress core RNA polymerase II binding transcription factor activity|nucleosome binding|histone binding|DNA binding transcription antitermination factor activity mitochondrion|nucleus|transcriptionally active chromatin
YPR135W CTF4 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.0108774469599595 0.528743527555464 1483 Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion DNA repair|replicative cell aging|double-strand break repair via break-induced replication|DNA replication initiation|DNA-dependent DNA replication|mitotic sister chromatid cohesion chromatin binding|DNA binding nuclear chromosome|replication fork protection complex|nuclear replication fork|nucleus
YOR132W VPS17 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM 0.0108770687964271 0.528757857520404 1484 Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes retrograde transport, endosome to Golgi protein transporter activity|phosphatidylinositol-3-phosphate binding endosome|retromer complex, outer shell|retromer complex
YMR032W HOF1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.010868605590706 0.529078610257301 1485 Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p cytokinesis after mitosis|barrier septum assembly involved in cell cycle cytokinesis|response to DNA damage stimulus|cytokinesis cytoskeletal protein binding cellular bud neck contractile ring|cellular bud neck septin ring
YEL024W RIP1 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0108655257668136 0.529564056919582 1486 Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|mitochondrial respiratory chain complex III
YBR284W_p YBR284W hom FT NUCLEOTIDE METABOLISM 0.0108067695123503 0.53142517637289 1487 Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication biological_process AMP deaminase activity|molecular_function cellular_component
YDR170C SEC7 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS|GOLGI APPARATUS 0.0107516780186507 0.533520231408267 1488 Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|autophagic vacuole assembly ARF guanyl-nucleotide exchange factor activity trans-Golgi network|cytosol|late endosome|integral to membrane|Golgi-associated vesicle
YJL022W_d YJL022W hom 0.0107105039311665 0.535088746193865 1489 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130 Unknown Unknown Unknown
YPL227C ALG5 hom FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0107101237350928 0.535103240473142 1490 UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum protein N-linked glycosylation dolichyl-phosphate beta-glucosyltransferase activity endoplasmic reticulum membrane
YCL056C PEX34 hom FT PEROXISOME ORGANIZATION 0.0106905313550765 0.535911243645624 1491 Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation peroxisome organization molecular_function integral to peroxisomal membrane|cytoplasm
YDR264C AKR1 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0106876151045735 0.536509359654174 1492 Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation palmitoyltransferase activity integral to membrane|Golgi apparatus|membrane
YDR092W UBC13 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|NUCLEUS 0.0106866475389225 0.535998610607233 1493 Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus postreplication repair|protein monoubiquitination|protein polyubiquitination|free ubiquitin chain polymerization ubiquitin-protein ligase activity ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YOR205C GEP3 hom FT MITOCHONDRION 0.0106837776315927 0.536168907235884 1494 Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1) maturation of SSU-rRNA molecular_function mitochondrion|mitochondrial inner membrane
YOL146W PSF3 het FT RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0106124883904252 0.538831946555661 1495 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery double-strand break repair via break-induced replication|DNA-dependent DNA replication molecular_function replication fork protection complex|GINS complex|DNA replication preinitiation complex
YGL090W LIF1 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.0105772051099724 0.540182614900549 1496 Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein double-strand break repair via nonhomologous end joining chromatin binding DNA ligase IV complex|nuclear chromatin|nucleus
YDR294C DPL1 hom FT KETONE METABOLISM|LIPID METABOLISM|SIGNALING|RESPONSE TO NUTRIENT LEVELS|ENDOPLASMIC RETICULUM 0.0105757833932749 0.540297480381082 1497 Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate calcium-mediated signaling|sphingolipid metabolic process|cellular response to starvation sphinganine-1-phosphate aldolase activity endoplasmic reticulum|cortical endoplasmic reticulum|perinuclear endoplasmic reticulum
YEL003W GIM4 hom FT PROTEIN COMPLEX ORG/BIOGENESIS 0.0105070811572388 0.54341390051943 1498 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YAL056C-A_d YAL056C-A hom 0.01049868351341 0.543194539353177 1499 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL150C MCM10 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0104840033514022 0.543758565730429 1500 Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|double-strand break repair via break-induced replication|DNA replication initiation|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette double-stranded DNA binding|protein binding|DNA replication origin binding|single-stranded DNA binding replication fork protection complex|replication fork|nucleus
YCR061W_p YCR061W hom 0.0104763385775722 0.544053169622209 1501 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation regulation of cell size molecular_function integral to membrane|cytoplasm
YER146W LSM5 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0104447623104149 0.545267673711358 1502 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex
YNL070W TOM7 hom FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0104205006134394 0.546201753580704 1503 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex protein import into mitochondrial matrix|protein import into mitochondrial outer membrane protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YCL061C MRC1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0104133484329321 0.546477265072939 1504 S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres maintenance of DNA repeat elements|intra-S DNA damage checkpoint|DNA repair|DNA replication checkpoint|telomere maintenance|replication fork protection|DNA replication|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere molecular_function nuclear chromosome|replication fork protection complex|nucleus|nuclear replication fork
YJL062W-A COA3 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0103576333438961 0.548625837362606 1505 Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation molecular_function mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YDR295C HDA2 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0103113640479709 0.550413309152317 1506 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance negative regulation of transcription from RNA polymerase II promoter|gene silencing by RNA|histone deacetylation|gene silencing involved in chronological cell aging histone deacetylase activity|chromatin binding|DNA binding nucleus|HDA1 complex
YJR118C ILM1 hom FF|FT MITOCHONDRION ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.010300107243122 0.550848614187363 1507 Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth mitochondrial genome maintenance molecular_function integral to membrane|endoplasmic reticulum
YDR301W CFT1 het FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS|MITOCHONDRION 0.010262215991222 0.552315126558333 1508 RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF mRNA cleavage|termination of RNA polymerase II transcription|mRNA polyadenylation RNA binding mRNA cleavage factor complex|mitochondrion|mRNA cleavage and polyadenylation specificity factor complex
YBR195C MSI1 hom FT CHROMATIN ORGANIZATION|NUCLEUS 0.010181033314513 0.555463589122718 1509 Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase DNA replication-dependent nucleosome assembly histone binding nucleus|CAF-1 complex|cytoplasm
YJL060W BNA3 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION 0.0101250446258289 0.557640059936815 1510 Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate kynurenic acid biosynthetic process arylformamidase activity|kynurenine-oxoglutarate transaminase activity mitochondrion|cytoplasm
YDR197W CBS2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.0101227829437855 0.557728066311858 1511 Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial ribosome
YMR058W FET3 hom FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.0101221603665722 0.557752293167912 1512 Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress iron assimilation by reduction and transport|high-affinity iron ion transport|response to copper ion ferroxidase activity|iron ion transmembrane transporter activity integral to membrane|high affinity iron permease complex|plasma membrane
YDR324C UTP4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0100004152504874 0.562499670522827 1513 Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|nucleolus|t-UTP complex|90S preribosome
YGL127C SOH1 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|RNA POL II, HOLOENZYME 0.00998610251945094 0.563059065338543 1514 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits DNA repair|meiotic gene conversion|meiotic sister chromatid segregation|transcription from RNA polymerase II promoter molecular_function core mediator complex|nucleus
YDR011W SNQ2 hom FF|FT NUCLEOTIDE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE 0.00995365245412177 0.564328327258114 1515 Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species response to drug xenobiotic-transporting ATPase activity mitochondrion|integral to membrane|plasma membrane
YNL139C THO2 hom FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|NUCLEUS 0.0099488085642885 0.56451791069158 1516 Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|DNA recombination|transcription elongation from RNA polymerase II promoter DNA binding|nucleic acid binding THO complex part of transcription export complex|nucleus|nucleoplasmic THO complex
YHR115C DMA1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION 0.00994149230444665 0.56480431748062 1517 Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma2p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8 protein, similar to human Chfr; contains FHA and RING finger establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint ubiquitin-protein ligase activity cytoplasm
YGR038W ORM1 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00993237834605938 0.565799826244601 1518 Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein molecular_function integral to membrane|endoplasmic reticulum|SPOTS complex
YJR007W SUI2 het FF|FT TRANSLATION|RIBOSOME 0.0099285711258692 0.565484297350633 1519 Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress translational initiation translation initiation factor activity ribosome|multi-eIF complex|eukaryotic translation initiation factor 2 complex|cytoplasm
YOL144W NOP8 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS 0.00991641087794658 0.56607650131164 1520 Nucleolar protein required for 60S ribosomal subunit biogenesis ribosomal large subunit biogenesis molecular_function nucleolus
YOR123C LEO1 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|RNA POL II, HOLOENZYME 0.00980875377906959 0.57018524727013 1521 Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay chromatin organization|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription-coupled nucleotide-excision repair|histone H3-K4 trimethylation|transcription elongation from RNA polymerase II promoter RNA binding|RNA polymerase II transcription factor binding transcription factor activity nucleus|Cdc73/Paf1 complex
YBR202W MCM7 het FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME 0.00980833660066254 0.570029080585297 1522 Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex S phase of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter|DNA replication initiation|DNA strand elongation involved in DNA replication|DNA unwinding involved in replication|pre-replicative complex assembly|double-strand break repair via break-induced replication|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere DNA replication origin binding|single-stranded DNA-dependent ATPase activity|transcription cofactor activity|single-stranded DNA binding|ATP-dependent 3'-5' DNA helicase activity|ATP binding|four-way junction helicase activity|DNA helicase activity|chromatin binding replication fork protection complex|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YHR041C SRB2 hom FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|RNA POL II, HOLOENZYME 0.0098032755538766 0.57022811949719 1523 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding core mediator complex
YOR072W_d YOR072W hom FF 0.00978923394359646 0.570780515891779 1524 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Unknown Unknown Unknown
YPR108W RPN7 het FT PROTEOLYSIS|NUCLEUS 0.00974266632998928 0.572786085607109 1525 Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits ubiquitin-dependent protein catabolic process structural molecule activity nucleus|proteasome regulatory particle, lid subcomplex
YKL113C RAD27 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION 0.00973287080771846 0.573000399018709 1526 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family double-strand break repair via nonhomologous end joining|replicative cell aging|DNA replication, removal of RNA primer|base-excision repair, base-free sugar-phosphate removal|gene conversion at mating-type locus, DNA repair synthesis 5'-3' exonuclease activity|5'-flap endonuclease activity mitochondrion|nucleus
YER022W SRB4 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.00972260307360819 0.573405238017602 1527 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination transcription initiation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter activating transcription factor binding|structural molecule activity|core RNA polymerase II recruiting transcription factor activity core mediator complex
YGL237C HAP2 hom FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS 0.00967134359801604 0.575599254703627 1528 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription CCAAT-binding factor complex|nucleus
YOR221C MCT1 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.00966152855709149 0.575816097414878 1529 Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling fatty acid metabolic process|aerobic respiration [acyl-carrier-protein] S-malonyltransferase activity mitochondrion
YDR125C ECM18 hom FT CELL WALL ORG/BIOGENESIS|MITOCHONDRION 0.00959175705678472 0.578576102612608 1530 Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function mitochondrion
YML123C PHO84 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.00954939418971341 0.580311374943133 1531 High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity phosphate ion transport|manganese ion transport|polyphosphate metabolic process manganese ion transmembrane transporter activity|inorganic phosphate transmembrane transporter activity integral to membrane|integral to plasma membrane
YDR475C JIP4 hom 0.00948186794461188 0.582935629128646 1532 Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence biological_process molecular_function cellular_component
YMR105W-A_p YMR105W-A hom 0.00944308151480608 0.584478014975354 1533 Putative protein of unknown function biological_process molecular_function cellular_component
YHL023C NPR3 hom FT CELL CYCLE|SIGNALING|RESPONSE TO NUTRIENT LEVELS 0.00943614769967178 0.584753945720031 1534 Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair meiosis|regulation of TOR signaling cascade|cellular response to amino acid starvation molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YER130C_p YER130C hom FT NUCLEUS 0.00942163493066047 0.585555487384508 1535 Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress biological_process sequence-specific DNA binding cellular_component
YHR143W DSE2 hom FF|FT CELL WALL ORG/BIOGENESIS|CELL DIVISION 0.00940335232545234 0.586059855256097 1536 Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP cytokinesis, completion of separation|pseudohyphal growth glucosidase activity extracellular region|fungal-type cell wall
YOR116C RPO31 het FF|FT NUCLEUS 0.00938379056612541 0.586839446511129 1537 RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YOR150W MRPL23 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.00930886844564763 0.58982973670565 1538 Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YPL175W SPT14 het FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00929752214754508 0.590948886539041 1539 UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins GPI anchor biosynthetic process UDP-glycosyltransferase activity glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum
YOR260W GCD1 het FT TRANSLATION 0.00927800737907741 0.591118833014768 1540 Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression regulation of translational initiation translation initiation factor activity|guanyl-nucleotide exchange factor activity eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YOL018C TLG2 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|GOLGI APPARATUS 0.00927681635653834 0.592053152615218 1541 Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) inositolphosphoceramide metabolic process|Golgi to vacuole transport|endocytosis|mannosyl-inositol phosphorylceramide metabolic process|protein exit from endoplasmic reticulum|vesicle fusion|CVT pathway SNAP receptor activity SNARE complex|trans-Golgi network|integral to endosome membrane
YPR146C_d YPR146C hom 0.00927575522367855 0.591153583757546 1542 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR025C BNA1 hom FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.00927514015513049 0.591510267485719 1543 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p de novo NAD biosynthetic process from tryptophan 3-hydroxyanthranilate 3,4-dioxygenase activity cytoplasm
YGL124C MON1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT 0.00922942370089094 0.593008178978943 1544 Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate autophagy|vesicle docking|protein targeting to vacuole molecular_function cytosol|fungal-type vacuole membrane|Mon1-Ccz1 complex
YJR074W MOG1 hom FT PROTEIN LOCALIZATION|RNA LOCALIZATION|NUCLEUS 0.00920503415865808 0.594040553965294 1545 Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p protein import into nucleus Ran GTPase binding nucleus
YPR092W_d YPR092W hom 0.00912245009090296 0.597573786698901 1546 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER164W CHD1 hom FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME|HISTONE ACETYLTRANSFERASE 0.00908401176927044 0.598846077470974 1547 Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes termination of RNA polymerase I transcription|ATP-dependent chromatin remodeling|nucleosome positioning|negative regulation of histone H3-K14 acetylation|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|regulation of transcriptional start site selection at RNA polymerase II promoter|nucleosome mobilization|Unknown|transcription elongation from RNA polymerase II promoter chromatin DNA binding|DNA-dependent ATPase activity|methylated histone residue binding|DNA binding|rDNA binding nuclear chromatin|SLIK (SAGA-like) complex|mitochondrion|SAGA complex|nucleolar chromatin
YBL010C_p YBL010C hom FT NUCLEUS 0.00904795176791092 0.60029781034657 1548 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles biological_process molecular_function clathrin-coated vesicle
YMR277W FCP1 het FF|FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.00903842115900316 0.600736068499207 1549 Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) dephosphorylation of RNA polymerase II C-terminal domain|regulation of transcription from RNA polymerase II promoter protein serine/threonine phosphatase activity nucleus
YPL247C_p YPL247C hom FT NUCLEUS 0.00903401501988093 0.600913595496903 1550 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest biological_process molecular_function nucleus|cytoplasm
YDR140W MTQ2 hom FT TRANSLATION|NUCLEUS 0.00897262072859883 0.603335669272857 1551 S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC peptidyl-glutamine methylation|regulation of translation protein methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity eRF1 methyltransferase complex|nucleus|cytoplasm
YLR153C ACS2 het FT CHROMATIN ORGANIZATION|COFACTOR METABOLISM|NUCLEUS 0.00896615079046757 0.603596903048384 1552 Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions histone acetylation|acetyl-CoA biosynthetic process|replicative cell aging acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity cytosol|nucleolus|nucleus
YGL161C YIP5 hom FT GOLGI APPARATUS 0.00895778863014571 0.603934613489988 1553 Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport biological_process Rab GTPase binding integral to membrane|Golgi apparatus
YHR120W MSH1 hom FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.00893100528334845 0.605016844241659 1554 DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis DNA repair|mismatch repair|mitochondrial DNA repair|mitochondrion organization|reciprocal meiotic recombination|mitochondrial genome maintenance guanine/thymine mispair binding|dinucleotide insertion or deletion binding|DNA-dependent ATPase activity mitochondrion
YER061C CEM1 hom FT KETONE METABOLISM|LIPID METABOLISM|MITOCHONDRION 0.00888414212296689 0.606912524355828 1555 Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration fatty acid biosynthetic process fatty acid synthase activity mitochondrion
YKL109W HAP4 hom FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS 0.00886557221260708 0.607664436100384 1556 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex regulation of cellular respiration|carbon catabolite activation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity CCAAT-binding factor complex
YLR148W PEP3 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT 0.00884705364942249 0.608682071145805 1557 Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|vacuole fusion, non-autophagic|late endosome to vacuole transport|vesicle docking involved in exocytosis|Golgi to endosome transport phosphatidylinositol binding|protein binding, bridging fungal-type vacuole membrane|HOPS complex|proteasome storage granule|CORVET complex|extrinsic to vacuolar membrane
YPL183W-A RTC6 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.00882302168493878 0.60938890800461 1558 Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress mitochondrial translation|ribosome biogenesis structural constituent of ribosome mitochondrial large ribosomal subunit
YOR047C STD1 hom FT TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM|NUCLEUS|PLASMA MEMBRANE 0.0087713864726733 0.611484476499258 1559 Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+] response to salt stress|signal transduction|nicotinamide riboside biosynthetic process|glucose metabolic process|nicotinic acid riboside biosynthetic process|regulation of transcription from RNA polymerase II promoter protein kinase activator activity plasma membrane|nucleus
YOR041C_d YOR041C hom 0.00876940091902912 0.611618232172123 1560 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YDR537C_d YDR537C hom 0.00870451156294018 0.61420326470573 1561 Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W Unknown Unknown Unknown
YDR238C SEC26 het FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.0086545696647343 0.616237109689537 1562 Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP) ER to Golgi vesicle-mediated transport molecular_function coated vesicle|COPI vesicle coat
YKR072C SIS2 hom FF|FT CELL CYCLE|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.00864013532429054 0.617035645754114 1563 Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis regulation of mitotic cell cycle|response to salt stress|coenzyme A biosynthetic process phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity phosphopantothenoylcysteine decarboxylase complex|nucleus|cytoplasm
YGR290W_d YGR290W hom 0.00863078764358685 0.617206651314258 1564 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter) Unknown Unknown Unknown
YJR097W JJJ3 hom FT NUCLEUS 0.00861110669201549 0.618009505901061 1565 Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 peptidyl-diphthamide biosynthetic process from peptidyl-histidine ferrous iron binding nucleus|cytoplasm
YML034C-A_d YML034C-A hom 0.00860604501348169 0.61821606319549 1566 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL143W CCT4 het FF 0.00855462619770863 0.620316072790071 1567 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo protein folding unfolded protein binding chaperonin-containing T-complex
YOR204W DED1 het FT TRANSLATION 0.008541531859805 0.620851357761471 1568 ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility translational initiation RNA strand annealing activity|ATP-dependent RNA helicase activity cytoplasm
YDL018C ERP3 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00852412931856398 0.621563068906825 1569 Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport vesicle-mediated transport molecular_function integral to membrane
YDR007W TRP1 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM 0.00850860188638849 0.622198392640988 1570 Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) tryptophan biosynthetic process phosphoribosylanthranilate isomerase activity cytoplasm
YGL198W YIP4 hom FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.00850465514551527 0.622671486293303 1571 Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport biological_process Rab GTPase binding integral to membrane|Golgi apparatus
YDR237W MRPL7 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.00845439284552855 0.624418625222521 1572 Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YMR216C SKY1 hom FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS 0.00843901460869017 0.625049091938397 1573 SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 cellular cation homeostasis|cellular ion homeostasis|response to drug|protein phosphorylation|positive regulation of protein import into nucleus|regulation of cell size|mRNA splice site selection protein serine/threonine kinase activity|protein kinase activity cytoplasm
YBL105C PKC1 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.00842401286568677 0.625922126732613 1574 Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) intracellular protein kinase cascade|regulation of nuclear-transcribed mRNA poly(A) tail shortening|fungal-type cell wall organization|signal transduction|actin filament organization|peroxisome degradation|protein phosphorylation|cytoplasmic mRNA processing body assembly protein kinase C activity site of polarized growth|cytoskeleton|nucleus|plasma membrane|cytoplasm
YJR015W_p YJR015W hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00827963350960217 0.631599377510013 1575 Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene biological_process molecular_function integral to membrane|endoplasmic reticulum|cytoplasm
YCR045C RRT12 hom FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS 0.00821017012025615 0.634513834688794 1576 Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores ascospore wall assembly serine-type peptidase activity nuclear envelope|ascospore wall
YGL040C HEM2 het FT COFACTOR METABOLISM|NUCLEUS 0.00820599483931526 0.634635633054796 1577 Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus heme biosynthetic process porphobilinogen synthase activity nucleus|cytoplasm
YKR035W-A DID2 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM 0.00818002983944852 0.635758064605642 1578 Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors late endosome to vacuole transport via multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole molecular_function late endosome|cytoplasm
YHR017W YSC83 hom FT MITOCHONDRION 0.00814085314988098 0.637477273002045 1579 Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 biological_process molecular_function mitochondrial outer membrane|mitochondrion
YPR064W_d YPR064W hom 0.0081314816937856 0.637714211425589 1580 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR040W GEF1 hom FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE 0.0081094832005644 0.638624297933685 1581 Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism cellular copper ion homeostasis|cellular iron ion homeostasis voltage-gated chloride channel activity endosome|integral to membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|fungal-type vacuole|Golgi medial cisterna
YGL242C_p YGL242C hom 0.00809573408865538 0.639193380756634 1582 Putative protein of unknown function; deletion mutant is viable biological_process molecular_function cellular_component
YJR060W CBF1 hom FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CHROMOSOME|KINETOCHORE 0.00805772606798744 0.640767656505062 1583 Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress regulation of transcription from RNA polymerase II promoter in response to methionine|negative regulation of transcription from RNA polymerase II promoter|methionine biosynthetic process|chromosome segregation|Unknown|chromatin remodeling|negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II repressing transcription factor binding|centromeric DNA binding chromosome, centromeric region|mitochondrion|nucleus|kinetochore
YPR137W RRP9 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.00805379850517457 0.64107976558226 1584 Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein rRNA modification|rRNA processing snoRNA binding box C/D snoRNP complex|small-subunit processome|nucleolus|90S preribosome
YNL237W YTP1 hom FF|FT MITOCHONDRION 0.008036994535915 0.641627029524085 1585 Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins biological_process molecular_function integral to membrane|membrane
YFL010W-A AUA1 hom 0.00802758748421575 0.642166091389012 1586 Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease amino acid transport molecular_function cellular_component
YNL111C CYB5 hom FF|FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00801742256974102 0.642587586356401 1587 Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation sterol biosynthetic process electron carrier activity endoplasmic reticulum membrane
YLR310C CDC25 het FT CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEUS|PLASMA MEMBRANE 0.00795287199958875 0.645316206358932 1588 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 regulation of cell cycle|replicative cell aging|Ras protein signal transduction|traversing start control point of mitotic cell cycle Ras guanyl-nucleotide exchange factor activity cytosol|nucleus|plasma membrane|cytoplasm
YGR063C SPT4 hom FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0078936078865997 0.647583850554461 1589 Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions 7-methylguanosine mRNA capping|chromosome segregation|chromatin organization|intracellular mRNA localization|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription, DNA-dependent|regulation of transcription-coupled nucleotide-excision repair|chromatin silencing|mRNA splicing, via spliceosome|Unknown core RNA polymerase I binding transcription factor activity|core RNA polymerase II binding transcription factor activity|rDNA binding DSIF complex|nuclear telomeric heterochromatin|rDNA heterochromatin|mating-type region heterochromatin|kinetochore
YLR163C MAS1 het FF|FT PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.00782704240199885 0.650746489605909 1590 Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins protein processing involved in protein targeting to mitochondrion metalloendopeptidase activity mitochondrion|mitochondrial processing peptidase complex
YCR026C NPP1 hom FT NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS 0.00777273343856981 0.652623033534014 1591 Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication cellular response to phosphate starvation|phosphate-containing compound metabolic process|nucleoside triphosphate metabolic process nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity cellular_component
YMR208W ERG12 het FF|FT LIPID METABOLISM|COFACTOR METABOLISM 0.0076998140068024 0.655670700530609 1592 Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate ergosterol biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway|farnesyl diphosphate biosynthetic process, mevalonate pathway mevalonate kinase activity cytosol
YMR263W SAP30 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.0076632838742444 0.657247485510891 1593 Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase II promoter histone deacetylase activity histone deacetylase complex|Rpd3L-Expanded complex|Rpd3L complex
YNL079C TPM1 hom FF|FT VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.00766079647404933 0.657303798748046 1594 Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication vacuole inheritance|exocytosis|intracellular mRNA localization|filamentous growth|budding cell apical bud growth|mitochondrion inheritance|budding cell isotropic bud growth|actin polymerization or depolymerization|actin filament organization|pseudohyphal growth|vesicle-mediated transport|establishment of cell polarity|actin filament bundle assembly actin lateral binding cellular bud neck contractile ring|actin filament bundle
YPR051W MAK3 hom FT NUCLEUS 0.00765477079131406 0.657556152802408 1595 Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatC complex
YKL068W-A_p YKL068W-A hom 0.00764190977840202 0.658094899235029 1596 Putative protein of unknown function; identified by homology to Ashbya gossypii biological_process molecular_function cellular_component
YBR251W MRPS5 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.00759688005149715 0.659982586931118 1597 Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YNL323W LEM3 hom FF|FT MEMBRANE ORGANIZATION|SIGNALING|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.00758276317185103 0.661715767228348 1598 Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane phospholipid translocation|cell surface receptor signaling pathway phospholipid-translocating ATPase activity integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YDL193W NUS1 het FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.00755138662119967 0.662317764167352 1599 Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY protein glycosylation prenyltransferase activity nuclear envelope|lipid particle|endoplasmic reticulum
YDL097C RPN6 het FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS 0.00753227737497102 0.66283615487274 1600 Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress proteasome assembly|ubiquitin-dependent protein catabolic process structural molecule activity proteasome storage granule|proteasome regulatory particle, lid subcomplex
YER012W PRE1 het FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.00746948200157154 0.665334928742994 1601 Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process endopeptidase activator activity proteasome storage granule|nucleus|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YNR035C ARC35 het FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.00746600228768433 0.665715690659662 1602 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin mitochondrion inheritance|receptor-mediated endocytosis|microtubule cytoskeleton organization|actin cytoskeleton organization structural molecule activity cytosol|Arp2/3 protein complex
YGR228W_d YGR228W hom 0.00743918676558273 0.666610240444365 1603 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Unknown Unknown Unknown
YGR033C TIM21 hom FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.00741593699412648 0.667589619320203 1604 Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity protein import into mitochondrial matrix molecular_function mitochondrion|mitochondrial inner membrane presequence translocase complex
YOR187W TUF1 hom FT TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.00739780960031858 0.668353614863023 1605 Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans mitochondrial translational elongation|mitochondrial translation GTPase activity|translation elongation factor activity mitochondrion|mitochondrial matrix
YHR209W CRG1 hom 0.00735139143446878 0.670311515220342 1606 S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin lipid homeostasis mRNA binding|S-adenosylmethionine-dependent methyltransferase activity|methyltransferase activity cellular_component
YNL271C BNI1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON 0.00725659559429123 0.674408466039355 1607 Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 barbed-end actin filament capping|actin nucleation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly|establishment of mitotic spindle orientation|formin-nucleated actin cable assembly profilin binding incipient cellular bud site|actin filament|polarisome|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YBR029C CDS1 het FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.00725638284819171 0.674325915509162 1608 Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids phosphatidylserine metabolic process|phosphatidylglycerol biosynthetic process phosphatidate cytidylyltransferase activity mitochondrion|integral to membrane|endoplasmic reticulum
YAL026C DRS2 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS|GOLGI APPARATUS 0.00725304772199225 0.674512756624421 1609 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease intracellular protein transport|post-Golgi vesicle-mediated transport|phospholipid translocation|endocytosis|ribosomal small subunit assembly phospholipid-translocating ATPase activity trans-Golgi network|integral to membrane
YPL252C YAH1 het FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.00723782635534176 0.675111070843244 1610 Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin ubiquinone biosynthetic process|iron-sulfur cluster assembly|heme a biosynthetic process oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor mitochondrial matrix
YKL041W VPS24 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM 0.007213540750017 0.67613916828267 1611 One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport molecular_function ESCRT III complex|cytoplasm
YMR286W MRPL33 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.00721016236259669 0.676555531611565 1612 Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YDR231C COX20 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.00720688531723028 0.676421022306791 1613 Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase mitochondrial respiratory chain complex IV assembly|protein processing|aerobic respiration unfolded protein binding mitochondrion|mitochondrial inner membrane
YNL246W VPS75 hom FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.00711158312451826 0.680461973469954 1614 NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress double-strand break repair via nonhomologous end joining|nucleosome assembly|positive regulation of histone acetylation histone binding|acetyltransferase activator activity chromatin|nucleus
YCR077C PAT1 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|TRANSLATION|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|RIBOSOME 0.00710476201821707 0.680841514698057 1615 Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|chromosome segregation|regulation of translational initiation|formation of translation preinitiation complex|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly molecular_function cytosolic small ribosomal subunit|cytoplasmic mRNA processing body
YER111C SWI4 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS|CHROMOSOME 0.00707074841971832 0.682196242946045 1616 DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription SBF transcription complex|nuclear chromatin
YNL069C RPL16B hom FT TRANSLATION|RIBOSOME 0.00706391672804328 0.682486552366305 1617 Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YHR170W NMD3 het FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS|RIBOSOME 0.00700588923404025 0.685488267354254 1618 Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex ribosomal large subunit export from nucleus ribosomal large subunit binding cytosol|cytosolic large ribosomal subunit
YPL251W_d YPL251W het 0.00699910671490823 0.685242953311605 1619 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C Unknown Unknown Unknown
YPL238C_d YPL238C het FF 0.00699122683174866 0.685711531092356 1620 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W Unknown Unknown Unknown
YDR084C TVP23 hom FT VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.00698641569589311 0.685783200559086 1621 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern vesicle-mediated transport molecular_function integral to membrane|integral to Golgi membrane|cytoplasm
YFR010W UBP6 hom FT PROTEOLYSIS 0.00693005129381514 0.688184528376043 1622 Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance protein deubiquitination ubiquitin-specific protease activity proteasome complex|proteasome regulatory particle
YLR043C TRX1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS|ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS 0.00687542753270222 0.690514700855314 1623 Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic disulfide oxidoreductase activity cytosol|fungal-type vacuole
YJL031C BET4 het FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN PRENYLATION 0.00677269678065825 0.695337398231721 1624 Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p protein targeting to membrane|protein geranylgeranylation|ER to Golgi vesicle-mediated transport Rab geranylgeranyltransferase activity Rab-protein geranylgeranyltransferase complex
YPR088C SRP54 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS 0.00676479471885573 0.695243113046082 1625 Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|SRP-dependent cotranslational protein targeting to membrane|protein targeting to ER 7S RNA binding|GTP binding|signal sequence binding signal recognition particle, endoplasmic reticulum targeting
YDR484W VPS52 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|GOLGI APPARATUS|CYTOSKELETON 0.00673222499076096 0.696766392514204 1626 Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin actin filament-based process|Golgi to vacuole transport|retrograde transport, endosome to Golgi protein binding Golgi apparatus|GARP complex
YOR061W CKA2 hom FF|FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS 0.00672981089313679 0.696740790459114 1627 Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching regulation of transcription from RNA polymerase I promoter|chronological cell aging|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein serine/threonine kinase activity protein kinase CK2 complex|UTP-C complex
YDR161W_p YDR161W hom FT PROTEOLYSIS|NUCLEUS 0.00669318024638084 0.698310236382045 1628 Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD) ER-associated protein catabolic process molecular_function nucleus|cytoplasm
YOR039W CKB2 hom FF|FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS 0.00667578714003774 0.69926938552248 1629 Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein serine/threonine kinase inhibitor activity|protein kinase regulator activity protein kinase CK2 complex|UTP-C complex|CURI complex
YGL250W RMR1 hom FT CELL CYCLE|NUCLEUS 0.00666354639453692 0.699580848011075 1630 Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus meiotic gene conversion|reciprocal meiotic recombination molecular_function nucleus|cytoplasm
YGR020C VMA7 hom FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS 0.00662389408254604 0.701282336999175 1631 Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane vacuolar acidification proton-transporting ATPase activity, rotational mechanism fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YOR106W VAM3 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS 0.00656924791486565 0.703629669850538 1632 Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region autophagic vacuole fusion|vesicle fusion with vacuole|piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle docking|vesicle fusion protein homodimerization activity|SNAP receptor activity SNARE complex|fungal-type vacuole membrane
YEL009C GCN4 hom FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.00655909186253751 0.7040662363863 1633 Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels nitrogen catabolite activation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription initiation from RNA polymerase II promoter|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels chromatin binding|TFIID-class binding transcription factor activity|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding transcription factor activity nucleus
YJL039C NUP192 het FT PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE 0.00652721417944321 0.705898123548901 1634 Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205 nucleocytoplasmic transport|nuclear pore organization structural constituent of nuclear pore integral to membrane|nuclear pore nuclear basket|nuclear pore|nuclear pore inner ring
YDL068W_d YDL068W hom 0.00651916091797728 0.705783645976346 1635 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL099C OCA1 hom FF|FT RESPONSE TO OXIDATIVE STRESS 0.00639866894248571 0.710975000179272 1636 Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA cellular response to oxidative stress protein tyrosine phosphatase activity cytoplasm
YML092C PRE8 het FF|FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION 0.00637402993698992 0.712161315167239 1637 Alpha 2 subunit of the 20S proteasome proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YOR008C SLG1 hom FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON 0.00636329908362674 0.712624369894045 1638 Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response positive regulation of endocytosis|Rho protein signal transduction|actin cytoskeleton organization|fungal-type cell wall organization|response to heat|peroxisome degradation|establishment of cell polarity|response to osmotic stress transmembrane signaling receptor activity plasma membrane|mating projection tip|cellular bud neck
YCR093W CDC39 het FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|NUCLEUS 0.00632491809558572 0.714566979135879 1639 Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor response to pheromone involved in conjugation with cellular fusion|regulation of cell cycle|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter molecular_function CCR4-NOT core complex|nucleus|cytoplasm
YBR170C NPL4 hom FT PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX 0.00619040152834483 0.719979681091804 1640 Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP) retrograde protein transport, ER to cytosol|proteasomal ubiquitin-dependent protein catabolic process|mitochondria-associated protein catabolic process|mitotic spindle disassembly|ER-associated protein catabolic process|ER-associated misfolded protein catabolic process|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process molecular_function Doa10p ubiquitin ligase complex|integral to membrane|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|Cdc48p-Npl4p-Vms1p AAA ATPase complex|nuclear outer membrane-endoplasmic reticulum membrane network
YDR359C EAF1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|HISTONE ACETYLTRANSFERASE 0.00598626499178457 0.728843613313771 1641 Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 DNA repair|cellular protein complex assembly|chromatin modification molecular_function histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YMR138W CIN4 hom FT SIGNALING 0.0059367966592894 0.730997125040995 1642 GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog protein folding|tubulin complex assembly|tubulin complex biogenesis GTP binding cytoplasm
YDR072C IPT1 hom FT LIPID METABOLISM 0.00588173954203728 0.733396427493972 1643 Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin mannosyl diphosphorylinositol ceramide metabolic process|sphingolipid biosynthetic process transferase activity, transferring phosphorus-containing groups integral to membrane
YGR257C MTM1 hom FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION 0.00585956587321964 0.734401570490157 1644 Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor manganese ion transport|transport transporter activity|metallochaperone activity mitochondrion|integral to membrane|mitochondrial inner membrane
YJL201W ECM25 hom FT SIGNALING|CELL WALL ORG/BIOGENESIS 0.00585182964268114 0.734700947538982 1645 Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p fungal-type cell wall organization|filamentous growth molecular_function cytoplasm
YBR298C MAL31 hom FT CARBOHYDRATE METABOLISM 0.00580469383670847 0.737060869907581 1646 Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C alpha-glucoside transport|transmembrane transport alpha-glucoside:hydrogen symporter activity integral to membrane|membrane
YOR349W CIN1 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS 0.00577831353494525 0.737910598424027 1647 Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl protein folding|tubulin complex assembly|tubulin complex biogenesis beta-tubulin binding cellular_component
YHL009C YAP3 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS 0.00574866018191909 0.739206536055922 1648 Basic leucine zipper (bZIP) transcription factor regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YJL120W_d YJL120W hom FF 0.00568839319335904 0.741842657430757 1649 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YML115C VAN1 hom FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.00565470634342101 0.743317466932037 1650 Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant protein N-linked glycosylation alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YHL031C GOS1 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.00563128854219136 0.744343253068297 1651 v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 Golgi vesicle transport|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|Golgi medial cisterna
YAL001C TFC3 het FF|FT PROTEIN LOCALIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME 0.00562808722592876 0.744483517814417 1652 Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding protein localization to chromatin|transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending transcription factor TFIIIC complex|mitochondrion|nuclear condensin complex
YAL045C_d YAL045C hom 0.00562542370070956 0.744600225858165 1653 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A Unknown Unknown Unknown
YDR479C PEX29 hom FT PEROXISOME ORGANIZATION 0.00557083645782632 0.746993370018393 1654 Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress peroxisome organization molecular_function integral to membrane|peroxisomal membrane
YCL051W LRE1 hom FT CELL WALL ORG/BIOGENESIS 0.0055467076459876 0.748051973698014 1655 Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway;
LRE1 has a paralog, HLR1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cellular_component
YJL095W BCK1 hom FF|FT SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|SITE OF POLARIZED GROWTH 0.00550687844818698 0.749800438973219 1656 Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p intracellular protein kinase cascade|endoplasmic reticulum unfolded protein response|peroxisome degradation|establishment of cell polarity|protein phosphorylation|response to acid|response to nutrient protein kinase activity|MAP kinase kinase kinase activity intracellular|mating projection tip
YMR290W-A_d YMR290W-A het FF 0.00531248306022235 0.758352518254692 1657 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase Unknown Unknown Unknown
YKL037W AIM26 hom FF|FT MITOCHONDRION 0.00517984718304697 0.764204677857467 1658 Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT mitochondrion degradation molecular_function mitochondrion|integral to membrane
YDL032W_d YDL032W hom 0.00516776439280224 0.764738469987533 1659 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene Unknown Unknown Unknown
YIL100W_d YIL100W hom 0.00515470574940787 0.76531549887927 1660 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A Unknown Unknown Unknown
YNR044W AGA1 hom 0.0051363091033306 0.766128621668436 1661 Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds agglutination involved in conjugation with cellular fusion cell adhesion molecule binding fungal-type cell wall
YOR035C SHE4 hom FF|FT CYTOSKELETON ORGANIZATION|RNA LOCALIZATION 0.00512199914722063 0.767065422384162 1662 Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization mating type switching|intracellular mRNA localization|actin cytoskeleton organization myosin binding cytoplasm
YFL032W_d YFL032W hom 0.0049814490871442 0.772983486907678 1663 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene Unknown Unknown Unknown
YHR012W VPS29 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM 0.00492856244517871 0.775328600733446 1664 Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval retrograde transport, endosome to Golgi protein transporter activity endosome|retromer complex, inner shell|retromer complex
YKL182W FAS1 het FF|FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.00492074314277203 0.775773176781965 1665 Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities fatty acid biosynthetic process palmitoyltransferase activity|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|fatty acid synthase activity|3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity cytosol|fatty acid synthase complex|mitochondrion|lipid particle|cytoplasm
YNL221C POP1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.00487052308131128 0.77800131524003 1666 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing ribonuclease MRP activity|ribonuclease P activity nucleolar ribonuclease P complex|ribonuclease MRP complex
YEL034W HYP2 het FF|FT KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION|RIBOSOME 0.00486046050211289 0.778447986845793 1667 Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication positive regulation of translational initiation|translational frameshifting|positive regulation of translational termination|positive regulation of translational elongation ribosome binding|RNA binding|translation elongation factor activity|translation initiation factor activity mitochondrion|cytosolic ribosome|cytoplasm
YGR222W PET54 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.0048190276569633 0.780287934340723 1668 Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing Group I intron splicing|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis translation regulator activity|RNA binding mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial inner membrane|mitochondrial matrix
YNR041C COQ2 hom FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM|MITOCHONDRION 0.00481620354990326 0.780317627939184 1669 Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis ubiquinone biosynthetic process 4-hydroxybenzoate octaprenyltransferase activity mitochondrion|integral to mitochondrial membrane|integral to membrane
YPR147C_p YPR147C hom 0.00468024544478484 0.786366614763366 1670 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS biological_process molecular_function cytoplasm
YPL153C RAD53 het FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEOTIDE METABOLISM|PROTEIN PHOSPHORYLATION|NUCLEUS 0.00467756425322143 0.786486036142859 1671 Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication DNA repair|protein localization|protein phosphorylation|nucleobase-containing compound metabolic process|DNA damage checkpoint|DNA replication initiation|deoxyribonucleoside triphosphate biosynthetic process protein serine/threonine/tyrosine kinase activity|DNA replication origin binding|protein kinase activity nucleus
YLR182W SWI6 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS 0.00465698312079913 0.787526681917903 1672 Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of reciprocal meiotic recombination|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity SBF transcription complex|MBF transcription complex|nucleus|cytoplasm
YPR074C TKL1 hom FF|FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS 0.00463262095174672 0.788488574679055 1673 Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication pentose-phosphate shunt transketolase activity cytoplasm
YGL045W RIM8 hom FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.00460087063849015 0.789995910634102 1674 Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family meiosis|protein processing|invasive growth in response to glucose limitation|ubiquitin-dependent endocytosis molecular_function internal side of plasma membrane
YDR424C DYN2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON 0.00456312460283845 0.791587871179414 1675 Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex microtubule-based process|actin filament-based process|nuclear pore complex assembly molecular_function cytoplasmic dynein complex|cytoplasmic microtubule|peroxisome|nuclear pore
YHL027W RIM101 hom FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|CELL DIVISION|ION HOMEOSTASIS|NUCLEUS 0.00455847300913662 0.791825765262406 1676 Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC meiosis|negative regulation of transcription from RNA polymerase II promoter|fungal-type cell wall biogenesis|cellular response to anoxia|response to pH|ascospore formation|barrier septum assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding nucleus
YKL079W SMY1 hom FT VESICLE-MEDIATED TRANSPORT|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.0045384561097462 0.792688795660316 1677 Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins exocytosis motor activity incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YER090W TRP2 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM 0.00449785162383713 0.795071787361765 1678 Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p tryptophan biosynthetic process anthranilate synthase activity anthranilate synthase complex|cytoplasm
YEL050C RML2 hom FF|FT KETONE METABOLISM|LIPID METABOLISM|TRANSLATION|MITOCHONDRION|RIBOSOME 0.00448755859113758 0.794961592821565 1679 Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor cytoplasmic translation|fatty acid metabolic process structural constituent of ribosome mitochondrial large ribosomal subunit
YDR080W VPS41 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING 0.00442219547319629 0.79788289301969 1680 Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole organization|vesicle-mediated transport|protein transport|vacuole fusion, non-autophagic|vacuolar protein processing Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding endosome|fungal-type vacuole membrane|HOPS complex
YNR006W VPS27 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT 0.00439246149002448 0.799447269272893 1681 Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole ubiquitin binding|phosphatidylinositol-3-phosphate binding endosome|ESCRT-0 complex
YNL026W SAM50 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.00437314011337779 0.800077206329493 1682 Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85 protein complex assembly|protein import into mitochondrial outer membrane protein channel activity mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to mitochondrial outer membrane
YOR319W HSH49 het FF|FT RNA PROCESSING|NUCLEUS 0.0042938970291926 0.803625185100936 1683 U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) mRNA splicing, via spliceosome RNA binding U2 snRNP|U2-type prespliceosome
YGL117W_p YGL117W hom FF 0.00424241023264153 0.806102822436605 1684 Putative protein of unknown function biological_process molecular_function cellular_component
YPR067W ISA2 hom FT KETONE METABOLISM|COFACTOR METABOLISM|MITOCHONDRION 0.00414288988229139 0.810397432864196 1685 Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations iron-sulfur cluster assembly|biotin biosynthetic process iron ion binding mitochondrion|mitochondrial intermembrane space
YHL046C PAU13 hom 0.00407908477918916 0.813263213927926 1686 Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock biological_process molecular_function cellular_component
YKL165C MCD4 het FF|FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.00401564831053307 0.816114917630904 1687 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes GPI anchor biosynthetic process|ATP transport mannose-ethanolamine phosphotransferase activity integral to membrane|fungal-type cell wall|endoplasmic reticulum|fungal-type vacuole
YKL163W PIR3 hom FT CELL WALL ORG/BIOGENESIS 0.00394702967786518 0.819202320378327 1688 O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication fungal-type cell wall organization structural constituent of cell wall fungal-type cell wall
YPL002C SNF8 hom FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.00391919514626904 0.820455499628672 1689 Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole molecular_function ESCRT II complex
YCR035C RRP43 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0038661167064453 0.822846489635785 1690 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing molecular_function nucleoplasm|nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|cytoplasm
YNL093W YPT53 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT|PLASMA MEMBRANE 0.00385268485685723 0.823451807136789 1691 Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication endocytosis|protein targeting to vacuole GTPase activity late endosome
YML034W SRC1 hom FF|FT CELL CYCLE|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS 0.00383722593567503 0.82425180002993 1692 Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance maintenance of rDNA|mitotic sister chromatid segregation molecular_function nuclear envelope
YPL160W CDC60 het FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION 0.00364809521566849 0.832684586582918 1693 Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA leucyl-tRNA aminoacylation|DNA replication initiation leucine-tRNA ligase activity cytoplasm
YMR033W ARP9 het FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RSC COMPLEX 0.0036410455875002 0.833027677497189 1694 Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation nucleosome positioning|ATP-dependent chromatin remodeling|nucleosome mobilization|chromatin organization|nucleosome disassembly|transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter DNA translocase activity RSC complex|SWI/SNF complex|nucleus
YLR119W SRN2 hom FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT 0.00360206222289992 0.834765207992125 1695 Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole protein binding endosome|ESCRT I complex
YER007W PAC2 hom FT CYTOSKELETON 0.00360136216691662 0.834821136720208 1696 Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl protein folding|tubulin complex assembly|tubulin complex biogenesis alpha-tubulin binding cellular_component
YDR320C SWA2 hom FF|FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00357703054543646 0.835897088259001 1697 Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles positive regulation of ATPase activity|endoplasmic reticulum inheritance|clathrin coat disassembly ubiquitin binding|clathrin binding endoplasmic reticulum membrane
YML011C RAD33 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.00356919796857484 0.836251330953885 1698 Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus nucleotide-excision repair molecular_function nucleus
YDR292C SRP101 het FT PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00355981622565238 0.836675681223018 1699 Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p SRP-dependent cotranslational protein targeting to membrane|protein targeting to ER GTP binding|signal recognition particle binding endoplasmic reticulum membrane|signal recognition particle receptor complex
YPL241C CIN2 hom FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON 0.00349256635835577 0.83971887694025 1700 GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 protein folding|tubulin complex assembly|tubulin complex biogenesis GTPase activator activity cellular_component
YKL110C KTI12 hom FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS 0.00348765933800735 0.840011665794647 1701 Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p regulation of transcription from RNA polymerase II promoter|cell growth|tRNA wobble uridine modification chromatin binding nucleus|cytoplasm
YGR092W DBF2 hom FF|FT CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.00345052366078025 0.841645919422377 1702 Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis nuclear division|protein phosphorylation|vacuolar acidification protein serine/threonine kinase activity|protein kinase activity spindle pole body|cellular bud neck
YIR005W IST3 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RNA LOCALIZATION|NUCLEUS 0.00342448162580185 0.842802293547131 1703 Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing mRNA export from nucleus|spliceosomal complex assembly|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step first spliceosomal transesterification activity RES complex|U2 snRNP
YDL077C VAM6 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION 0.00338259283505192 0.844700550984047 1704 Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle-mediated transport|vacuole organization|vacuole fusion, non-autophagic Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding fungal-type vacuole membrane|HOPS complex|fungal-type vacuole
YOL127W RPL25 het FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME 0.00338155719023801 0.844747494350272 1705 Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23 cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YPR201W ARR3 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.00336077895874966 0.845689439389895 1706 Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite arsenite transport|antimonite transport antiporter activity|arsenite transmembrane transporter activity|antimonite transmembrane transporter activity integral to membrane|plasma membrane
YDR047W HEM12 het FF|FT COFACTOR METABOLISM|NUCLEUS 0.00330599378744973 0.84817408376426 1707 Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda heme biosynthetic process uroporphyrinogen decarboxylase activity nucleus|cytoplasm
YKL211C TRP3 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM 0.00320731143861135 0.853001277112526 1708 Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p tryptophan biosynthetic process indole-3-glycerol-phosphate synthase activity|anthranilate synthase activity anthranilate synthase complex|cytoplasm
YJR139C HOM6 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS 0.00311214349521079 0.857188737665422 1709 Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process homoserine dehydrogenase activity nucleus|cytoplasm
YER133W GLC7 het FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CELL DIVISION|CARBOHYDRATE METABOLISM 0.00306706297043979 0.859089927853537 1710 Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest replication fork processing|glycogen metabolic process|chromosome segregation|regulation of cell shape during vegetative growth phase|termination of RNA polymerase II transcription, poly(A)-coupled|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|rRNA processing|regulation of cell cycle|ascospore formation|protein localization to kinetochore|cell budding|DNA damage checkpoint|meiosis|termination of RNA polymerase II transcription, exosome-dependent|DNA replication checkpoint|response to heat|cellular ion homeostasis|histone dephosphorylation|regulation of carbohydrate metabolic process protein serine/threonine phosphatase activity protein phosphatase type 1 complex|mating projection base|condensed nuclear chromosome kinetochore|mRNA cleavage and polyadenylation specificity factor complex|nucleolus|spindle pole body|cellular bud neck
YER083C GET2 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.00303646420758159 0.860419436996556 1711 Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane protein anchor integral to membrane|endoplasmic reticulum|GET complex
YDR321W ASP1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.00302159474889042 0.861095996569634 1712 Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively asparagine catabolic process asparaginase activity intracellular
YGR070W ROM1 hom FT SIGNALING|NUCLEOTIDE METABOLISM 0.00301085438610612 0.861686930917087 1713 GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP small GTPase mediated signal transduction|activation of Rho GTPase activity Rho guanyl-nucleotide exchange factor activity intracellular
YDR126W SWF1 hom FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|CYTOSKELETON 0.00298364956569309 0.862822961046078 1714 Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion ascospore wall assembly|cortical actin cytoskeleton organization|establishment of cell polarity|vacuole fusion, non-autophagic|regulation of exocytosis|protein palmitoylation palmitoyltransferase activity integral to membrane|actin filament bundle|nuclear outer membrane-endoplasmic reticulum membrane network|actin cortical patch
YCR009C RVS161 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|SITE OF POLARIZED GROWTH|CYTOSKELETON 0.00297193537603916 0.863396583154407 1715 Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress conjugation with cellular fusion|actin cytoskeleton reorganization|endocytosis|actin cortical patch localization|response to starvation|response to osmotic stress|lipid tube assembly|actin cytoskeleton organization cytoskeletal protein binding|lipid binding membrane raft|mating projection tip|mating projection|actin cortical patch
YOR323C PRO2 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS 0.00295171085766835 0.864598096374536 1716 Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis proline biosynthetic process glutamate-5-semialdehyde dehydrogenase activity nucleus|cytoplasm
YDR108W TRS85 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|GOLGI APPARATUS 0.00269134180906177 0.876147864546259 1717 Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role meiosis|vesicle organization|piecemeal microautophagy of nucleus|ER to Golgi vesicle-mediated transport|peroxisome degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway molecular_function TRAPP complex|pre-autophagosomal structure
YGL063W PUS2 hom FT RNA PROCESSING|MITOCHONDRION 0.00268330573557893 0.876514704454264 1718 Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion
YKR043C SHB17 hom FT CARBOHYDRATE METABOLISM|NUCLEUS 0.00267241356050675 0.877011965279169 1719 Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus ribose phosphate biosynthetic process sedoheptulose-bisphosphatase activity nucleus|cytoplasm
YDR008C_d YDR008C hom FF 0.00266431102749592 0.87763609883488 1720 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR538W PAD1 hom FT KETONE METABOLISM|MITOCHONDRION 0.00263461267826556 0.878738065351536 1721 Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX cinnamic acid catabolic process|aromatic compound catabolic process mRNA binding|carboxy-lyase activity mitochondrion
YMR162C DNF3 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|GOLGI APPARATUS 0.00252229665425593 0.883870116004753 1722 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase intracellular protein transport|phospholipid translocation phospholipid-translocating ATPase activity trans-Golgi network transport vesicle|integral to membrane
YPL267W ACM1 hom FT CELL CYCLE|CELL DIVISION|NUCLEUS 0.00248856067525734 0.885412574340211 1723 Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle ubiquitin-protein ligase inhibitor activity nucleus|cytoplasm
YOR275C RIM20 hom FT ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS|NUCLEUS 0.00245337061315594 0.88702197799908 1724 Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation proteolysis|response to pH|protein processing|invasive growth in response to glucose limitation|sporulation resulting in formation of a cellular spore molecular_function nucleus|cytoplasm
YNL065W AQR1 hom FT PLASMA MEMBRANE 0.00240027030402734 0.889451379438099 1725 Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress monocarboxylic acid transport|drug transmembrane transport|amino acid export monocarboxylic acid transmembrane transporter activity|drug transmembrane transporter activity integral to membrane|plasma membrane
YGL095C VPS45 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.00236327891780524 0.891192791852152 1726 Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment vacuole inheritance|CVT pathway|positive regulation of SNARE complex assembly|Golgi vesicle fusion to target membrane|Golgi to vacuole transport|vacuole organization|vacuolar acidification|protein targeting to vacuole|Golgi to endosome transport unfolded protein binding|SNARE binding cytosol|SNARE complex|Golgi membrane|extrinsic to membrane
YJR102C VPS25 hom FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS 0.00234704018186149 0.891935833757425 1727 Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole structural molecule activity ESCRT II complex
YMR122C_d YMR122C hom 0.00229347871255716 0.894340340398947 1728 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR477W SNF1 hom FT KETONE METABOLISM|SIGNALING|TRANSLATION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION 0.0022926343193714 0.894379013292713 1729 AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation negative regulation of translation|protein phosphorylation|replicative cell aging|signal transduction|biofilm formation|positive regulation of gluconeogenesis|pseudohyphal growth|cell adhesion|regulation of carbohydrate metabolic process|invasive growth in response to glucose limitation|cellular response to nitrogen starvation AMP-activated protein kinase activity|protein kinase activity mitochondrion|AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|fungal-type vacuole|cytoplasm
YLR207W HRD3 hom FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX 0.00217568294447617 0.89973772694847 1730 Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events ER-associated protein catabolic process ubiquitin-protein ligase activity Hrd1p ubiquitin ligase ERAD-M complex|luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YPR159W KRE6 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.00216862193958107 0.900091060515139 1731 Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process glucosidase activity integral to endoplasmic reticulum membrane|integral to membrane|site of polarized growth|transport vesicle|plasma membrane
YBL058W SHP1 hom FT PROTEIN LOCALIZATION|CELL CYCLE|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION|NUCLEUS 0.00211316137462915 0.902676630260463 1732 UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate glycogen metabolic process|proteasomal ubiquitin-dependent protein catabolic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|ascospore formation|sister chromatid biorientation|autophagic vacuole assembly protein phosphatase type 1 regulator activity nucleus|cytoplasm
YAL024C LTE1 hom FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION 0.00210010871661312 0.903346707413289 1733 Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint|vesicle-mediated transport guanyl-nucleotide exchange factor activity cellular bud
YML121W GTR1 hom FF|FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|GENE SILENCING|NUCLEUS 0.00201680784523354 0.907024664814722 1734 Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB phosphate ion transport|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|chromatin silencing at telomere GDP binding|GTP binding fungal-type vacuole membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YGR095C RRP46 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.0020081201775152 0.907423363219711 1735 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5) nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing molecular_function nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YLR025W SNF7 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT 0.00199774041723233 0.907899746469353 1736 One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes cellular response to anoxia|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport protein binding ESCRT III complex|cytoplasm
YNL005C MRP7 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.00195683776006054 0.909790706551059 1737 Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome|peptidyltransferase activity mitochondrion|mitochondrial large ribosomal subunit
YLR304C ACO1 hom FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION 0.00194172680225835 0.910471080938568 1738 Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy propionate metabolic process|glutamate biosynthetic process|tricarboxylic acid cycle|mitochondrial genome maintenance|citrate metabolic process double-stranded DNA binding|aconitate hydratase activity|single-stranded DNA binding mitochondrial nucleoid|cytosol|mitochondrion|mitochondrial matrix
YNL052W COX5A hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.00192285813396125 0.911337469533873 1739 Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YOL027C MDM38 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION 0.00192004267229538 0.911466755542835 1740 Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome potassium ion transport|mitochondrial respiratory chain complex III biogenesis|cellular potassium ion homeostasis|proton transport|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis|protein insertion into mitochondrial membrane ribosome binding mitochondrion|mitochondrial inner membrane
YGL123W RPS2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|NUCLEUS|RIBOSOME 0.00191211277933456 0.911844002014203 1741 Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5 positive regulation of translational fidelity|rRNA export from nucleus structural constituent of ribosome|SSU rRNA binding small-subunit processome|cytosolic small ribosomal subunit
YHR206W SKN7 hom FF|FT TRANSCRIPTION FROM RNA POL II|SIGNALING|RESPONSE TO OXIDATIVE STRESS|NUCLEUS 0.0018675106987151 0.913905034621186 1742 Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; SKN7 has a paralog, HMS2, that arose from the whole genome duplication response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|transcription, DNA-dependent|response to osmotic stress|regulation of cell size sequence-specific DNA binding|two-component response regulator activity|sequence-specific DNA binding transcription factor activity nucleus
YLR131C ACE2 hom FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|NUCLEUS 0.00180562988126094 0.916833952764349 1743 Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YHR143W-A RPC10 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.00180408274030276 0.916793631786862 1744 RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YBL045C COR1 hom FT OXIDATION-REDUCTION PROCESS|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.00178387555476655 0.917722282608144 1745 Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YLL063C AYT1 hom 0.00176358770967393 0.918654753144532 1746 Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis secondary metabolic process trichothecene 3-O-acetyltransferase activity cellular_component
YKL077W_p YKL077W hom 0.00176073744135242 0.918785766250746 1747 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole biological_process molecular_function fungal-type vacuole
YLR372W SUR4 hom FF|FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM|ENDOPLASMIC RETICULUM 0.00173016564251548 0.920191142470039 1748 Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis post-Golgi vesicle-mediated transport|fatty acid elongation|fatty acid biosynthetic process|sphingolipid biosynthetic process fatty acid elongase activity integral to membrane|endoplasmic reticulum
YNL064C YDJ1 hom FT PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION 0.00170444107637733 0.921373886130874 1749 Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family protein refolding|ER-associated protein catabolic process|protein targeting to mitochondrion|protein targeting to ER|'de novo' protein folding unfolded protein binding|ATPase activator activity cytosol|TRC complex|perinuclear region of cytoplasm
YDL164C CDC9 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|NUCLEUS|MITOCHONDRION|CHROMOSOME 0.00169953418843008 0.921599510948083 1750 DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination lagging strand elongation|base-excision repair|mitotic cell cycle|DNA ligation|DNA recombination|nucleotide-excision repair DNA ligase (ATP) activity mitochondrion|nucleus|replication fork
YIL008W URM1 hom FT RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS 0.00164783806685593 0.9239769427557 1751 Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|invasive growth in response to glucose limitation|tRNA wobble uridine modification protein tag cytosol|nucleus|cytoplasm
YFL001W DEG1 hom FT RNA PROCESSING|NUCLEUS 0.00161716291823329 0.925487867766654 1752 tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability tRNA pseudouridine synthesis pseudouridine synthase activity nucleus|cytoplasm
YNL243W SLA2 hom FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON 0.00156329402131448 0.927866457829996 1753 Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo bipolar cellular bud site selection|fungal-type cell wall organization|actin filament organization|endocytosis|exocytosis protein binding, bridging incipient cellular bud site|mating projection tip|actin cortical patch
YOR312C RPL20B hom FT TRANSLATION|RIBOSOME 0.00156150931678695 0.927948583461318 1754 Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGL168W HUR1 hom FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS 0.0014729726654467 0.932023664489503 1755 Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene DNA replication molecular_function cellular_component
YJR033C RAV1 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM 0.00146700903295425 0.932298218148956 1756 Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate early endosome to late endosome transport|vacuolar acidification|regulation of protein complex assembly molecular_function RAVE complex|cytoplasm|extrinsic to membrane
YHR182W YHR182W hom FT SIGNALING 0.00142970954870733 0.934015592843589 1757 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cytoplasm
YDR452W PPN1 hom FT NUCLEUS 0.00140381639794421 0.935207968412388 1758 Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress polyphosphate catabolic process|polyphosphate metabolic process endopolyphosphatase activity|exopolyphosphatase activity fungal-type vacuole membrane|nucleus
YAL067W-A_p YAL067W-A hom 0.00139031993613118 0.935839083898135 1759 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YOL050C_d YOL050C hom 0.00138835058524584 0.935920236162012 1760 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Unknown Unknown Unknown
YHR183W GND1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION 0.00138174202594971 0.93627206497978 1761 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication cellular response to oxidative stress|pentose-phosphate shunt, oxidative branch phosphogluconate dehydrogenase (decarboxylating) activity mitochondrion|cytoplasm
YLR024C UBR2 hom 0.00136231387304918 0.9371194551905 1762 Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex protein monoubiquitination ubiquitin-protein ligase activity cytoplasm
YPL069C BTS1 hom FF|FT PROTEIN LOCALIZATION|LIPID METABOLISM|MITOCHONDRION 0.00131854800518418 0.939208077912041 1763 Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic terpenoid biosynthetic process farnesyltranstransferase activity mitochondrion
YDR245W MNN10 hom FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.00131135909300087 0.939493810160608 1764 Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family N-glycan processing|cell wall mannoprotein biosynthetic process|substituted mannan metabolic process|barrier septum assembly alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YBR283C SSH1 hom FT PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00126732154487782 0.941495874149958 1765 Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential SRP-dependent cotranslational protein targeting to membrane protein transmembrane transporter activity|signal sequence binding integral to membrane|Ssh1 translocon complex
YGR036C CAX4 hom FT LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.0012181120696706 0.943763720941563 1766 Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation lipid biosynthetic process|protein N-linked glycosylation dolichyldiphosphatase activity integral to endoplasmic reticulum membrane|integral to membrane
YBL036C YBL036C hom 0.00117933268118367 0.945551213206451 1767 Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS biological_process pyridoxal phosphate binding cellular_component
YMR040W YET2 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.00117043331735539 0.945969503659513 1768 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein biological_process molecular_function ribosome|integral to membrane
YER082C UTP7 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.00116261518508617 0.946329864243121 1769 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|nucleolus|90S preribosome
YOR012W_p YOR012W hom 0.00115531248152339 0.946690309784074 1770 Putative protein of unknown function biological_process molecular_function cellular_component
YIL128W MET18 hom FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE|NUCLEUS 0.0011374433572291 0.947505824201931 1771 Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19 methionine metabolic process|nucleotide-excision repair|transcription from RNA polymerase II promoter molecular_function cytoplasm
YIL011W TIR3 hom 0.00112837433400114 0.947923771961734 1772 Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth biological_process molecular_function fungal-type cell wall
YPL152W RRD2 hom FT CELL CYCLE|CYTOSKELETON ORGANIZATION 0.00112589719514318 0.948014708911412 1773 Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress mitotic spindle organization in nucleus|response to osmotic stress peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity protein phosphatase type 2A complex
YCR030C SYP1 hom FT CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH 0.0010985358586106 0.949276321686629 1774 Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization septin cytoskeleton organization|actin cortical patch assembly molecular_function mating projection base|mating projection tip|cellular bud neck|cellular bud tip
YDL173W PAR32 hom 0.00109094163231711 0.94962650901132 1775 Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene biological_process molecular_function cytoplasm
YDR532C KRE28 hom FT ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE 0.00108776745473132 0.949772880561136 1776 Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components biological_process molecular_function chromosome, centromeric region|condensed nuclear chromosome kinetochore|spindle pole body
YMR041C ARA2 hom FT OXIDATION-REDUCTION PROCESS 0.00107708493389722 0.950265498411968 1777 NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase dehydro-D-arabinono-1,4-lactone biosynthetic process D-arabinose 1-dehydrogenase [NAD(P)+] activity cellular_component
YNL127W FAR11 hom FT CELL CYCLE|SIGNALING 0.00106398934019898 0.950869419530551 1778 Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 re-entry into mitotic cell cycle after pheromone arrest molecular_function cellular_component
YMR256C COX7 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.0010547230620192 0.951340298334804 1779 Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YEL049W PAU2 hom 0.00104921394467643 0.951550840844055 1780 Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme biological_process molecular_function cellular_component
YDR382W RPP2B hom FT TRANSLATION|RIBOSOME 0.00104143537868178 0.951909592076227 1781 Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm translational elongation|cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YOR152C_p YOR152C hom 0.0010407229866797 0.951942448428542 1782 Putative protein of unknown function; YOR152C is not an essential gene biological_process molecular_function membrane
YIL029C_p YIL029C hom 0.00103183159121339 0.952352536837928 1783 Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W biological_process molecular_function integral to membrane
YOL141W PPM2 hom FT RNA PROCESSING|MITOCHONDRION 0.00102784558591147 0.952536383236443 1784 AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p tRNA methylation|wybutosine biosynthetic process tRNA methyltransferase activity mitochondrion|cytoplasm
YMR135W-A_d YMR135W-A hom 0.00102665774883954 0.95263355073993 1785 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR098C_p YJR098C hom FT LIPID METABOLISM|MITOCHONDRION 0.000999704142943357 0.953834421410537 1786 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion|cytoplasm
YER060W-A FCY22 hom 0.000966213497560389 0.955432552578009 1787 Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function transmembrane transport nucleobase transmembrane transporter activity integral to membrane
YDR413C_d YDR413C het 0.000964864847728365 0.955454845891309 1788 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing Unknown Unknown Unknown
YLR059C REX2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000936952399000491 0.956729312831764 1789 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease U5 snRNA 3'-end processing|U4 snRNA 3'-end processing|mitochondrial genome maintenance|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 3'-5'-exoribonuclease activity|3'-5' exonuclease activity mitochondrion
YDL105W NSE4 het FT RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.000930998582728501 0.957029632460386 1790 Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair DNA repair molecular_function Smc5-Smc6 complex|nucleus
YGL146C_p RRT6 hom 0.000917879475730975 0.957609308249782 1791 Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins biological_process molecular_function membrane
YDL235C YPD1 het FT SIGNALING|NUCLEUS 0.000894614725945558 0.958682777919552 1792 Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus osmosensory signaling pathway via two-component system protein histidine kinase binding|transferase activity, transferring phosphorus-containing groups nucleus|cytoplasm
YAL066W_d YAL066W hom 0.000894536686848206 0.958729481329482 1793 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR262C BUD32 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|LIPID METABOLISM|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|NUCLEUS|CHROMOSOME 0.000878505335041503 0.95942613283893 1794 Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription threonylcarbamoyladenosine metabolic process|protein phosphorylation|telomere maintenance|cellular bud site selection|positive regulation of transcription from RNA polymerase II promoter protein serine/threonine kinase activity EKC/KEOPS complex|nucleus|cytoplasm
YDR048C_d YDR048C hom 0.000840861795157044 0.961163300146309 1795 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR039C RIC1 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS 0.000821457891063621 0.962058820535774 1796 Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes intracellular protein transport|retrograde transport, endosome to Golgi guanyl-nucleotide exchange factor activity nucleus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YBR200W BEM1 hom FT SITE OF POLARIZED GROWTH|CYTOSKELETON 0.000799359657271981 0.963078746648261 1797 Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p establishment of cell polarity|cell morphogenesis involved in conjugation with cellular fusion protein complex scaffold|phosphatidylinositol-3-phosphate binding incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip
YAL061W_p BDH2 hom FT OXIDATION-REDUCTION PROCESS|NUCLEUS 0.000795520832613665 0.963255930700015 1798 Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3 biological_process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor nucleus|cytoplasm
YDR107C TMN2 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT 0.000788680372786071 0.963571662136567 1799 Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments cellular copper ion homeostasis|pseudohyphal growth|vacuolar transport|invasive growth in response to glucose limitation molecular_function fungal-type vacuole membrane|integral to membrane
YPL041C_p YPL041C hom 0.000781758682665375 0.963928828953764 1800 Protein of unknown function involved in maintenance of proper telomere length biological_process molecular_function cellular_component
YGR216C GPI1 het FT LIPID METABOLISM|ENDOPLASMIC RETICULUM 0.000764450759021804 0.964690061021235 1801 Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs GPI anchor biosynthetic process phosphatidylinositol N-acetylglucosaminyltransferase activity glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane
YBL017C PEP1 hom FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|GOLGI APPARATUS 0.000759984466514604 0.964896225339045 1802 Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments vacuolar transport|protein targeting to vacuole signal sequence binding integral to membrane|Golgi apparatus
YPR187W RPO26 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME 0.000758615433991247 0.964959420429038 1803 RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YFL041W FET5 hom FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.000757505702441273 0.965026290236919 1804 Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport iron ion transport ferroxidase activity fungal-type vacuole membrane|integral to membrane
YDL208W NHP2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 0.000751797168057409 0.965274157585788 1805 Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing cleavage involved in rRNA processing|rRNA pseudouridine synthesis|snRNA pseudouridine synthesis snoRNA binding box H/ACA snoRNP complex
YMR076C PDS5 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 0.000751592479168617 0.965299128394538 1806 Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis double-strand break repair|meiosis|synapsis|mitotic chromosome condensation|mitotic sister chromatid cohesion structural molecule activity condensed nuclear chromosome
YPR180W AOS1 het FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.000751157835387182 0.965407222736411 1807 Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability protein sumoylation SUMO activating enzyme activity nucleus|SUMO activating enzyme complex
YDR165W TRM82 hom FT RNA PROCESSING|NUCLEUS 0.00074582345999646 0.965549913654047 1808 Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p tRNA methylation tRNA (guanine-N7-)-methyltransferase activity tRNA methyltransferase complex|nucleus
YOL105C WSC3 hom FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION|SITE OF POLARIZED GROWTH 0.000727063753614547 0.966415918796151 1809 Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis response to heat|peroxisome degradation|Rho protein signal transduction transmembrane signaling receptor activity mating projection tip
YGR018C_p YGR018C hom 0.000724122027865327 0.966551721427146 1810 Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W biological_process molecular_function cellular_component
YLR390W-A CCW14 hom FT CELL WALL ORG/BIOGENESIS|MITOCHONDRION 0.00071761850031386 0.966871719235537 1811 Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall fungal-type cell wall organization structural constituent of cell wall mitochondrion|fungal-type cell wall
YBL081W_p YBL081W hom 0.000704912012730498 0.967511425399282 1812 Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport biological_process molecular_function cellular_component
YOL154W ZPS1 hom 0.000687889714109552 0.968224438161472 1813 Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH biological_process molecular_function fungal-type cell wall|fungal-type vacuole
YJR137C MET5 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS 0.000685208775532808 0.968371805692269 1814 Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine fungal-type cell wall organization|sulfate assimilation sulfite reductase (NADPH) activity sulfite reductase complex (NADPH)|cytoplasm
YDR094W_d YDR094W hom 0.000680853112266593 0.968549309413429 1815 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2 Unknown Unknown Unknown
YOR345C_d YOR345C hom 0.000671355549403457 0.96898780847192 1816 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 Unknown Unknown Unknown
YJR008W MHO1 hom FT NUCLEUS 0.000669893003009096 0.969078400524064 1817 Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility biological_process molecular_function nucleus|cytoplasm
YPR037C ERV2 hom FT OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000667685467260965 0.969157257361115 1818 Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER protein thiol-disulfide exchange thiol oxidase activity integral to endoplasmic reticulum membrane
YCL023C_d YCL023C hom 0.000666183667468224 0.969226596348963 1819 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4 Unknown Unknown Unknown
YKL122C SRP21 het FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEUS 0.000665718119864255 0.96924809100541 1820 Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER signal sequence binding nucleus|signal recognition particle, endoplasmic reticulum targeting
YMR074C YMR074C hom FT NUCLEUS 0.000662770112400515 0.969384203076742 1821 Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress apoptotic process molecular_function nucleus|cytoplasm
YKL220C FRE2 hom FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|PLASMA MEMBRANE 0.00066211005630618 0.969414678563587 1822 Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels iron ion transport|copper ion import ferric-chelate reductase activity integral to membrane|plasma membrane
YLR209C PNP1 hom FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM 0.000661750263849446 0.969431290580031 1823 Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway guanosine catabolic process|inosine catabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinate nucleotide salvage nicotinamide riboside hydrolase activity|inosine nucleosidase activity|purine-nucleoside phosphorylase activity intracellular
YLR268W SEC22 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.000659320069995097 0.969543495670234 1824 R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion with endoplasmic reticulum|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle membrane
YGR088W CTT1 hom FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS 0.000644883506216596 0.970210062226737 1825 Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide response to reactive oxygen species catalase activity cytoplasm
YOR087W YVC1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS 0.000641592550996239 0.970362015489015 1826 Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock cellular cation homeostasis voltage-gated ion channel activity|calcium activated cation channel activity|sodium channel activity|calcium channel activity|potassium channel activity fungal-type vacuole membrane|fungal-type vacuole
YGR022C_d YGR022C hom 0.000636131151793814 0.970614187023253 1827 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W Unknown Unknown Unknown
YIR023W DAL81 hom FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.000632913838142127 0.970762742806386 1828 Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process|urea catabolic process RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YJR001W AVT1 hom FT VACUOLAR TRANSPORT 0.000627073755356308 0.971110217239195 1829 Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid transport|vacuolar transport transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YDR517W GRH1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000625279009069981 0.971115276367234 1830 Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress protein secretion|ER to Golgi vesicle-mediated transport|Golgi organization molecular_function COPII vesicle coat|cis-Golgi network|cytoplasm
YIL010W DOT5 hom FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|CHROMOSOME 0.000624111204067957 0.971169199547799 1831 Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth cellular response to oxidative stress|cell redox homeostasis thioredoxin peroxidase activity nucleus
YPL135W ISU1 hom FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM|MITOCHONDRION 0.000622388687013735 0.971248736695451 1832 Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification ferrous iron binding mitochondrion|mitochondrial matrix
YBR090C_p YBR090C hom FT NUCLEUS 0.000621892164256851 0.971301649734016 1833 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus biological_process molecular_function nucleus|cytoplasm
YDR139C RUB1 hom 0.000614808802756932 0.971598740896352 1834 Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme) protein neddylation protein tag cytoplasm
YNL263C YIF1 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS 0.000610617076430202 0.97179229789567 1835 Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3 ER to Golgi vesicle-mediated transport molecular_function integral to membrane|integral to Golgi membrane|endoplasmic reticulum membrane|ER to Golgi transport vesicle
YML065W ORC1 het FT GENE SILENCING|NUCLEUS|CHROMOSOME 0.000589206061656532 0.972780997781199 1836 Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity pre-replicative complex assembly|DNA replication initiation|chromatin silencing at silent mating-type cassette chromatin binding|DNA replication origin binding|ATPase activity|ATP binding DNA replication preinitiation complex|nucleus|pre-replicative complex|nuclear origin of replication recognition complex
YGR023W MTL1 hom FT CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS|PLASMA MEMBRANE 0.000585644743716358 0.972977730564503 1837 Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p cellular response to glucose starvation|fungal-type cell wall organization|cellular response to oxidative stress molecular_function integral to plasma membrane
YJL058C BIT61 hom FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE 0.000579670216401033 0.973221349594376 1838 Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity molecular_function TORC2 complex|plasma membrane|cytoplasm
YBL086C_p YBL086C hom 0.000577725566608137 0.973311151770508 1839 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function cellular_component
YJL171C YJL171C hom FT MITOCHONDRION|PLASMA MEMBRANE 0.000569563398737299 0.973688077007525 1840 GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrion|fungal-type cell wall|plasma membrane
YGL081W_p YGL081W hom 0.000560838780930356 0.974090982421948 1841 Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis biological_process molecular_function cellular_component
YNL218W MGS1 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.000546033054695721 0.974774730278891 1842 Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress regulation of DNA repair|DNA replication, Okazaki fragment processing|DNA strand renaturation ubiquitin binding|single-stranded DNA-dependent ATPase activity|enzyme activator activity nucleus|cytoplasm
YFR016C YFR016C hom 0.000544969598522833 0.974823842799025 1843 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene biological_process molecular_function cellular bud|cytoplasm
YPR055W SEC8 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.000524993003615662 0.975746419188028 1844 Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress Golgi inheritance|endoplasmic reticulum inheritance|Golgi to plasma membrane transport|exocytosis|vesicle fusion|vesicle docking involved in exocytosis molecular_function incipient cellular bud site|cellular bud neck|mating projection tip|exocyst|cellular bud tip
YMR008C PLB1 hom FT LIPID METABOLISM|PLASMA MEMBRANE 0.000518341545162711 0.976053609855079 1845 Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol glycerophospholipid metabolic process lysophospholipase activity periplasmic space|plasma membrane
YDR242W AMD2 hom 0.00051396978105352 0.97630157158107 1846 Putative amidase biological_process amidase activity cellular_component
YDL157C_p YDL157C hom FT MITOCHONDRION 0.000500039890559393 0.97689887085889 1847 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YHR005C-A TIM10 het FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000496801498527285 0.977048438560235 1848 Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane protein import into mitochondrial inner membrane protein transporter activity|unfolded protein binding mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex|mitochondrial intermembrane space protein transporter complex
YDR023W SES1 het FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION 0.000495202130131601 0.977122306954431 1849 Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p seryl-tRNA aminoacylation serine-tRNA ligase activity cytoplasm
YLR211C_p YLR211C hom 0.000492331414047157 0.977254894277009 1850 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron biological_process molecular_function cytoplasm
YGL114W_p YGL114W hom FT PROTEIN LOCALIZATION 0.000491318042857265 0.977301698140593 1851 Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters transport oligopeptide transporter activity integral to membrane|membrane
YFL009W CDC4 het FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX 0.000486326601157815 0.97753558475241 1852 F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p meiosis|G2/M transition of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle ubiquitin-protein ligase activity|ubiquitin binding nuclear SCF ubiquitin ligase complex|SCF ubiquitin ligase complex|nucleus|nuclear matrix
YBL015W ACH1 hom FT KETONE METABOLISM|COFACTOR METABOLISM|MITOCHONDRION 0.00048095734170441 0.977780225023149 1853 Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth acetate metabolic process acetate CoA-transferase activity|acetyl-CoA hydrolase activity cytosol|mitochondrion
YKL013C ARC19 het FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.000478468314080362 0.977895186261423 1854 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches mitochondrion inheritance|actin cortical patch assembly structural molecule activity Arp2/3 protein complex
YOR301W RAX1 hom FT CELL CYCLE|SIGNALING|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.000473852456347513 0.978108381058627 1855 Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily cellular bud site selection molecular_function integral to membrane|cellular bud neck
YMR270C RRN9 het FT NUCLEUS 0.000469337039099031 0.978326636759991 1856 Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I transcription of nuclear large rRNA transcript from RNA polymerase I promoter TBP-class protein binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity nucleolus|RNA polymerase I upstream activating factor complex
YLR305C STT4 het FT LIPID METABOLISM|SIGNALING|MITOCHONDRION|PLASMA MEMBRANE 0.000465659202549494 0.978486810574362 1857 Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization phosphatidylinositol phosphorylation 1-phosphatidylinositol 4-kinase activity mitochondrion|plasma membrane
YIL108W YIL108W hom FT PROTEOLYSIS 0.000460401669028682 0.978729647772302 1858 Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress biological_process molecular_function cytoplasm
YDR202C RAV2 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS 0.000459406174023719 0.978775628342209 1859 Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme vacuolar acidification|regulation of protein complex assembly molecular_function RAVE complex
YLR004C THI73 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE 0.000458663001311552 0.978822592902739 1860 Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs transport transporter activity integral to membrane|endoplasmic reticulum
YBR165W UBS1 hom FT PROTEIN LOCALIZATION|NUCLEUS 0.000453664457236209 0.979040831857669 1861 Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity protein export from nucleus|protein ubiquitination molecular_function nucleus
YOR300W_d YOR300W hom 0.000451943831438285 0.979120306102751 1862 Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7 Unknown Unknown Unknown
YER064C VHR2 hom FT NUCLEUS 0.000450998779399245 0.979163957342431 1863 Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress regulation of transcription, DNA-dependent molecular_function nucleus
YKL205W LOS1 hom FT RNA PROCESSING|RNA LOCALIZATION|NUCLEUS|MITOCHONDRION 0.000448562195345213 0.979285771090269 1864 Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus tRNA binding|Ran GTPase binding mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YLR414C PUN1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|PLASMA MEMBRANE 0.000437996320580872 0.979764537366872 1865 Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress fungal-type cell wall organization|protein oligomerization molecular_function integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YCL074W YCL074W hom FT NUCLEUS 0.000433935714543644 0.979952098016885 1866 Pseudogene: encodes fragment of Ty Pol protein transposition, RNA-mediated ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity retrotransposon nucleocapsid
YCR084C TUP1 hom FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.000432418402204825 0.980022183428441 1867 General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes nucleosome positioning|regulation of transcription from RNA polymerase II promoter in response to osmotic stress|histone exchange|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown ubiquitin binding|histone deacetylase binding|histone binding|phosphatidylinositol-3,5-bisphosphate binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|mediator complex binding nucleus|transcriptional repressor complex
YAL068C PAU8 hom FT TRANSCRIPTION FROM RNA POL II 0.000421543258248291 0.98052741961011 1868 Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YLR396C VPS33 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT 0.000414055416262036 0.980870390943998 1869 ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole regulation of SNARE complex assembly|endocytosis|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle fusion with vacuole|Golgi to vacuole transport|vacuole organization|vacuole fusion, non-autophagic|vesicle docking|protein targeting to vacuole phosphatidylinositol binding|ATP binding cytosol|fungal-type vacuole membrane|HOPS complex|fungal-type vacuole|CORVET complex
YLR290C_p YLR290C hom FT MITOCHONDRION 0.000406628497958281 0.981213455066558 1870 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene biological_process molecular_function mitochondrion
YGL067W NPY1 hom FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM 0.000405428001884245 0.981268908694741 1871 NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member NADH metabolic process NAD+ diphosphatase activity peroxisome|cytoplasm
YOR347C PYK2 hom FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.000403714914951706 0.981348040210329 1872 Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication pyruvate metabolic process pyruvate kinase activity cytosol|mitochondrion
YPR011C_p YPR011C hom FT MITOCHONDRION 0.000398245196923377 0.981603443594338 1873 Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies transport transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YOL123W HRP1 het FT RNA PROCESSING|NUCLEUS 0.000396067519201336 0.981701293637528 1874 Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences mRNA cleavage|mRNA polyadenylation mRNA binding|RNA binding mRNA cleavage factor complex|nucleus|cytoplasmic stress granule|cytoplasm
YDL184C RPL41A hom FT TRANSLATION|RIBOSOME 0.000382754461529162 0.982316267482992 1875 Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGR177C ATF2 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000382068707277401 0.982363740818129 1876 Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking steroid metabolic process|response to toxin|Unknown|sterol acetylation alcohol O-acetyltransferase activity integral to endoplasmic reticulum membrane|endoplasmic reticulum|cytoplasm
YML022W APT1 hom FT NUCLEOTIDE METABOLISM|NUCLEUS 0.000380964783201705 0.982398939410086 1877 Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication AMP biosynthetic process|adenine salvage adenine phosphoribosyltransferase activity nucleus|cytoplasm
YBR147W RTC2 hom FT MITOCHONDRION 0.000377243052008757 0.982570860679983 1878 Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter biological_process molecular_function mitochondrion|integral to membrane
YMR006C PLB2 hom FT LIPID METABOLISM 0.000373427573675113 0.982747113335559 1879 Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine glycerophospholipid metabolic process lysophospholipase activity extracellular region|fungal-type cell wall
YHL006C SHU1 hom FT RESPONSE TO DNA DAMAGE|NUCLEUS 0.000372860370199557 0.982773314871799 1880 Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function recombinational repair|maintenance of rDNA molecular_function nucleolus|Shu complex
YBR012C_d YBR012C hom 0.000366435185792137 0.983070122703788 1881 Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p Unknown Unknown Unknown
YGR041W BUD9 hom FT CELL CYCLE|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE 0.000366021683178268 0.983089224308481 1882 Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole cellular bud site selection molecular_function plasma membrane|cellular bud neck
YLR214W FRE1 hom FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|PLASMA MEMBRANE 0.000365130991624345 0.983130369517728 1883 Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels iron ion transport|copper ion import ferric-chelate reductase activity integral to membrane|plasma membrane
YJR153W PGU1 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 0.000361567037155005 0.983295005693426 1884 Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins pseudohyphal growth|pectin catabolic process polygalacturonase activity extracellular region
YJR078W BNA2 hom FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM 0.000347309026694592 0.983953658725363 1885 Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp de novo NAD biosynthetic process from tryptophan tryptophan 2,3-dioxygenase activity|indoleamine 2,3-dioxygenase activity cytoplasm
YDL039C PRM7 hom 0.000332978374748738 0.984615678468242 1886 Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements conjugation with cellular fusion molecular_function integral to membrane
YDL218W_p YDL218W hom 0.000324457604999067 0.985009309558863 1887 Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin biological_process molecular_function integral to membrane|cytoplasm
YFL014W HSP12 hom FT MEMBRANE ORGANIZATION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|PLASMA MEMBRANE 0.000321243507060085 0.985157791096532 1888 Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension cellular response to oxidative stress|cell adhesion|plasma membrane organization|cellular response to osmotic stress|cellular response to heat lipid binding cytosol|endosome|nucleus|plasma membrane|cytoplasm
YDR330W UBX5 hom FT PROTEOLYSIS|NUCLEUS 0.000312761637398964 0.985558249813085 1889 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p proteasomal ubiquitin-dependent protein catabolic process molecular_function nucleus|cytoplasm
YOR267C HRK1 hom FT ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS 0.000310094239354611 0.98567285726472 1890 Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress protein phosphorylation|cellular ion homeostasis protein serine/threonine kinase activity|protein kinase activity cytoplasm
YLR405W DUS4 hom FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS 0.000309228781155064 0.985721361735084 1891 Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p tRNA modification tRNA dihydrouridine synthase activity cellular_component
YGR008C STF2 hom FT MITOCHONDRION 0.000306832754465847 0.9858298720285 1892 Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress cellular response to desiccation molecular_function cytoplasm
YOR279C RFM1 hom FT GENE SILENCING|NUCLEUS 0.000305199211786092 0.985898996265459 1893 DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance chromatin silencing|chromatin silencing at silent mating-type cassette unfolded protein binding histone deacetylase complex|nucleus
YLR205C HMX1 hom FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 0.000304248418724495 0.985949209248973 1894 ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants response to oxidative stress|cellular iron ion homeostasis|heme catabolic process heme oxygenase (decyclizing) activity endoplasmic reticulum|membrane|nuclear outer membrane
YDR169C STB3 hom FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.000297689293389511 0.986245939395698 1895 Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter by glucose sequence-specific DNA binding nucleus|cytoplasm
YJR109C CPA2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM 0.000292662616711382 0.986478163207989 1896 Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor arginine biosynthetic process carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carbamoyl-phosphate synthase complex
YCR028C FEN2 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PLASMA MEMBRANE 0.000290027848957719 0.986599885402797 1897 Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress pantothenate transmembrane transport|endocytosis pantothenate transmembrane transporter activity integral to membrane|plasma membrane
YKR060W UTP30 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS 0.000285018079774318 0.986831329847728 1898 Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit ribosomal small subunit biogenesis molecular_function nucleolus|nucleus|90S preribosome
YOR298C-A MBF1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION 0.000283512733925758 0.986902827995442 1899 Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress positive regulation of transcription from RNA polymerase II promoter transcription coactivator activity mitochondrion|nucleus
YLR026C SED5 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.00028039494754336 0.987046844731792 1900 cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|cis-Golgi network
YLR199C PBA1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS 0.000272414549833085 0.987413600449363 1901 Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly proteasome assembly molecular_function cytoplasm
YGR246C BRF1 het FT TRANSLATION|NUCLEUS 0.000271912391101033 0.987442420061797 1902 TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB DNA-dependent transcriptional open complex formation|transposon integration|RNA polymerase III transcriptional preinitiation complex assembly|negative regulation of protein homodimerization activity TFIIIC-class transcription factor binding|RNA polymerase III core binding|DNA binding|TFIIIB-type transcription factor activity transcription factor TFIIIB complex
YHR132W-A IGO2 hom FT NUCLEUS 0.000271526466088946 0.987454629295199 1903 Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p mRNA stabilization molecular_function nucleus|cytoplasm
YBR169C SSE2 hom 0.00027098517815897 0.987479636434031 1904 Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication protein folding|protein refolding adenyl-nucleotide exchange factor activity cytoplasm
YKL166C TPK3 hom FT SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS 0.000270155936500575 0.98753284293099 1905 cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication protein phosphorylation|mitochondrion organization|Ras protein signal transduction cAMP-dependent protein kinase activity|protein kinase activity cAMP-dependent protein kinase complex|nucleus|cytoplasm
YDL007W RPT2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS 0.000262304457925092 0.987880681541705 1906 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle positive regulation of protein catabolic process|proteasome regulatory particle assembly|peptide catabolic process|ubiquitin-dependent protein catabolic process ATPase activity proteasome regulatory particle, base subcomplex|nucleus
YOR373W NUD1 het FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON 0.000261278690845677 0.98792807169255 1907 Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance meiotic chromosome segregation|spindle pole body separation|exit from mitosis|establishment of spindle localization structural constituent of cytoskeleton spindle pole body
YDR110W FOB1 hom FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME 0.000251978027405846 0.988357761652662 1908 Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases extrachromosomal circular DNA accumulation involved in cell aging|negative regulation of DNA replication|rDNA condensation|chromatin silencing at rDNA|replicative cell aging|protein localization to nucleolar rDNA repeats|DNA recombination rDNA spacer replication fork barrier binding nucleolus|rDNA heterochromatin
YBR089W_d YBR089W het 0.000249438434758619 0.988475091236267 1909 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30 Unknown Unknown Unknown
YGR292W MAL12 hom FT CARBOHYDRATE METABOLISM 0.000245998502747245 0.988642492850274 1910 Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose sucrose catabolic process|maltose catabolic process sucrose alpha-glucosidase activity|maltose alpha-glucosidase activity plasma membrane
YBR294W SUL1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 0.000243898079571226 0.988737779650738 1911 High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates sulfate transport|transmembrane transport sulfate transmembrane transporter activity integral to membrane|plasma membrane
YPR026W ATH1 hom FT CARBOHYDRATE METABOLISM 0.000241889846935313 0.988823838653442 1912 Acid trehalase required for utilization of extracellular trehalose trehalose catabolic process|response to stress alpha,alpha-trehalase activity fungal-type cell wall|cell wall-bounded periplasmic space|fungal-type vacuole
YGR136W LSB1 hom FT NUCLEUS 0.000230863556064753 0.989338032944816 1913 Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YGL125W MET13 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION 0.000228841795710803 0.989426668212964 1914 Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway methionine biosynthetic process methylenetetrahydrofolate reductase (NADPH) activity mitochondrion
YGR074W SMD1 het FT RNA PROCESSING|NUCLEUS 0.000227718466625874 0.989478567129544 1915 Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1; protein abundance increases in response to DNA replication stress mRNA splicing, via spliceosome mRNA binding commitment complex|U1 snRNP|U4/U6 x U5 tri-snRNP complex|U2-type prespliceosome|U5 snRNP
YLR280C_d YLR280C hom 0.000226576609547502 0.989531322103384 1916 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR169C PUS6 hom FT RNA PROCESSING|MITOCHONDRION 0.000224129658763734 0.98964437390524 1917 tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion|cytoplasm
YJR108W ABM1 hom FT CYTOSKELETON ORGANIZATION 0.000219235146280879 0.989870506355256 1918 Protein of unknown function, required for normal microtubule organization microtubule cytoskeleton organization molecular_function cellular_component
YLR122C_d YLR122C hom 0.000216720618256668 0.989986680936141 1919 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C Unknown Unknown Unknown
YGR278W CWC22 het FT RNA PROCESSING|NUCLEUS 0.000213388160006425 0.990140645321499 1920 Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein mRNA splicing, via spliceosome molecular_function U2-type spliceosomal complex|U2-type catalytic step 1 spliceosome
YDR487C RIB3 het FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.000213230611177442 0.99014792431413 1921 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration riboflavin biosynthetic process|aerobic respiration 3,4-dihydroxy-2-butanone-4-phosphate synthase activity cytosol|mitochondrial intermembrane space
YBL099W ATP1 hom FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION 0.000204558520684653 0.99054999839815 1922 Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrial nucleoid|proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, catalytic core
YCL035C GRX1 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS|NUCLEUS 0.000199798890265585 0.990768492953867 1923 Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress protein glutathionylation|cellular response to oxidative stress disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity nucleus|cytoplasm
YGR010W NMA2 hom FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS 0.000199207551014194 0.990801304672522 1924 Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication NAD biosynthetic process nicotinamide-nucleotide adenylyltransferase activity nucleus
YNL157W IGO1 hom FT NUCLEUS 0.000198895501938845 0.99081160147232 1925 Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p mRNA stabilization molecular_function nucleus|cytoplasmic mRNA processing body|cytoplasm
YKL164C PIR1 hom FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS 0.000188939248472853 0.991270231207152 1926 O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication intracellular protein transport|fungal-type cell wall organization structural constituent of cell wall fungal-type cell wall
YCR102W-A_d YCR102W-A hom 0.000187788948706965 0.991323377677254 1927 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YFR004W RPN11 het FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION|NUCLEUS|MITOCHONDRION 0.000187032303895748 0.99137510193 1928 Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress protein deubiquitination|proteasomal ubiquitin-dependent protein catabolic process|peroxisome fission|mitochondrial fission metallopeptidase activity|ubiquitin-specific protease activity cytosol|mitochondrion|proteasome storage granule|nucleus|proteasome regulatory particle, lid subcomplex
YOR126C IAH1 hom FT KETONE METABOLISM|LIPID METABOLISM 0.000183489150923563 0.991528360824148 1929 Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing acetate metabolic process hydrolase activity, acting on ester bonds cellular_component
YDL011C_d YDL011C hom 0.000177336216300499 0.99181732141505 1930 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W Unknown Unknown Unknown
YML025C YML6 het FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME 0.000175259401407913 0.991903481155685 1931 Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YDR358W GGA1 hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|GOLGI APPARATUS 0.000173180988464781 0.991998301991591 1932 Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi Golgi to vacuole transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to endosome transport ubiquitin binding trans-Golgi network
YKL144C RPC25 het FT NUCLEUS 0.000171828512056215 0.992060790082614 1933 RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p transcription initiation from RNA polymerase III promoter|tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YOL022C TSR4 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS 0.000171756887469722 0.992064099334807 1934 Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2 maturation of SSU-rRNA molecular_function cytoplasm
YDL176W YDL176W hom 0.000171233540241293 0.992094179528921 1935 Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene biological_process molecular_function cellular_component
YER171W RAD3 het FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME 0.000170962312291894 0.992100810894801 1936 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress regulation of transposition, RNA-mediated|phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair, DNA incision|regulation of mitotic recombination|transcription from RNA polymerase II promoter damaged DNA binding|ATP-dependent 5'-3' DNA helicase activity|core RNA polymerase binding transcription factor activity core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YDL197C ASF2 hom FT GENE SILENCING|NUCLEUS|CHROMOSOME 0.000166505549193175 0.992306725923201 1937 Anti-silencing protein that causes derepression of silent loci when overexpressed chromatin silencing at silent mating-type cassette molecular_function nuclear chromosome, telomeric region|nucleus
YOL075C_p YOL075C hom FT NUCLEOTIDE METABOLISM 0.000165811739745725 0.992338781923442 1938 Putative ABC transporter transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YKL152C GPM1 het FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION 0.000162682882631013 0.992483344311316 1939 Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis gluconeogenesis|glycolysis phosphoglycerate mutase activity cytosol|mitochondrion
YLR223C IFH1 het FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|GENE SILENCING|NUCLEUS|CHROMOSOME 0.000161143743327217 0.99255445715827 1940 Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|chromatin silencing at telomere transcription coactivator activity nuclear chromatin|nucleolus|nucleus|CURI complex
YML053C_p YML053C hom FT NUCLEUS 0.000158677863673882 0.992669481487845 1941 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene biological_process molecular_function nucleus|cytoplasm
YER065C ICL1 hom FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM 0.000156371478873297 0.992774950446635 1942 Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose glyoxylate cycle isocitrate lyase activity cellular_component
YMR037C MSN2 hom FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS 0.00015448718272999 0.992862010873856 1943 Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|cellular response to methylmercury|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YJR037W_d YJR037W hom 0.000153123033719923 0.992933482631175 1944 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces Unknown Unknown Unknown
YOR079C ATX2 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 0.000153063147464032 0.992930969826743 1945 Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation cellular manganese ion homeostasis manganese ion transmembrane transporter activity integral to membrane|Golgi membrane
YDL138W RGT2 hom FT SIGNALING|PLASMA MEMBRANE 0.000152779697390184 0.99294090215747 1946 Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication glucose transport|signal transduction|detection of glucose glucose transmembrane transporter activity|receptor activity|glucose binding integral to membrane|plasma membrane
YNL001W DOM34 hom FT CELL CYCLE|TRANSLATION|CELL DIVISION 0.00015196739822388 0.992981574326631 1947 Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|nonfunctional rRNA decay ribosome binding|endoribonuclease activity cytoplasm
YNL042W BOP3 hom FT NUCLEUS 0.000148401605629476 0.993147274780597 1948 Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury cellular response to methylmercury molecular_function nucleus|cytoplasm
YDR171W HSP42 hom FT CYTOSKELETON ORGANIZATION|CYTOSKELETON 0.00014795640854862 0.993173953961957 1949 Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress cytoskeleton organization unfolded protein binding cytoskeleton|chaperonin-containing T-complex|cytoplasm
YGL139W FLC3 hom FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 0.000143865388679575 0.993357730006206 1950 Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER FAD transport|transmembrane transport FAD transmembrane transporter activity mitochondrion|integral to membrane|endoplasmic reticulum
YDR446W ECM11 hom FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|NUCLEUS 0.000143708086386038 0.993364992491137 1951 Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure fungal-type cell wall organization|reciprocal meiotic recombination molecular_function nucleus
YOR218C_d YOR218C het 0.000142659111797713 0.993408506969941 1952 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W Unknown Unknown Unknown
YER067W RGI1 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS|PLASMA MEMBRANE 0.000142147581635185 0.993432141431133 1953 Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress energy reserve metabolic process molecular_function cell periphery|nucleus|cytoplasm
YDR168W CDC37 het FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION 0.000141590046759904 0.993457901475592 1954 Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding regulation of stress-activated MAPK cascade|regulation of cell cycle|MAPK cascade involved in osmosensory signaling pathway|protein stabilization|spindle pole body duplication associated with nuclear envelope unfolded protein binding cytoplasm
YDR215C_d YDR215C hom 0.000141566149295602 0.993462907693592 1955 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein Unknown Unknown Unknown
YPL107W_p YPL107W hom FT MITOCHONDRION 0.000135306093536435 0.993748242368796 1956 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene biological_process molecular_function mitochondrion
YDR133C_d YDR133C hom 0.000135027027168932 0.993770445016586 1957 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C Unknown Unknown Unknown
YOR090C PTC5 hom FT MITOCHONDRION 0.000133216908827245 0.993848442237434 1958 Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p positive regulation of catalytic activity|regulation of catalytic activity|protein dephosphorylation [pyruvate dehydrogenase (lipoamide)] phosphatase activity|protein serine/threonine phosphatase activity mitochondrion
YPR159C-A_p YPR159C-A hom 0.0001316079573582 0.99391910974623 1959 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YDR013W PSF1 het FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.00013122285586268 0.993936902855833 1960 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery double-strand break repair via break-induced replication|DNA-dependent DNA replication molecular_function GINS complex|replication fork protection complex|DNA replication preinitiation complex
YPL142C_d YPL142C het 0.000130869248856951 0.993962262959463 1961 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit Unknown Unknown Unknown
YLR269C_d YLR269C hom 0.000130141090316117 0.993986884430451 1962 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YFL021W GAT1 hom FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS 0.000129378189388999 0.994022133292915 1963 Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p nitrogen catabolite activation of transcription from RNA polymerase II promoter|nitrogen catabolite activation of transcription sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity cytosol|nucleus
YNL078W NIS1 hom FT CELL CYCLE|NUCLEUS|SITE OF POLARIZED GROWTH 0.000128723536920468 0.994052380682975 1964 Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network regulation of mitosis molecular_function nucleus|cellular bud neck
YIL155C GUT2 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|MITOCHONDRION 0.000127848685614753 0.994092802095385 1965 Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner NADH oxidation|replicative cell aging|glycerol metabolic process glycerol-3-phosphate dehydrogenase activity mitochondrion|integral to mitochondrial outer membrane
YLR267W_p BOP2 hom 0.000127831691859943 0.994093587270761 1966 Protein of unknown function biological_process molecular_function cellular_component
YNL047C SLM2 hom FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE 0.000125146984108229 0.99423662888156 1967 Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization phosphatidylinositol binding plasma membrane
YER044C ERG28 hom FT LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 0.000120413591977964 0.994436331916077 1968 Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p ergosterol biosynthetic process protein binding, bridging endoplasmic reticulum membrane
YDL036C PUS9 hom FT RNA PROCESSING|NUCLEUS|MITOCHONDRION 0.000119338949132717 0.994485984620823 1969 Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion|nucleus|cytoplasm
YLL046C RNP1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS 0.00011914431032075 0.994499083101488 1970 Ribonucleoprotein that contains two RNA recognition motifs (RRM) ribosome biogenesis RNA binding cytoplasm
YER063W THO1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION|NUCLEUS 0.000118924357103994 0.994509238225594 1971 Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation poly(A)+ mRNA export from nucleus|transcription, DNA-dependent|ribonucleoprotein complex assembly chromatin binding|double-stranded DNA binding|RNA binding nucleus
YBL003C HTA2 hom FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 0.000115607409018097 0.994658396540901 1972 Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p DNA repair|chromatin assembly or disassembly DNA binding replication fork protection complex|nuclear nucleosome
YDR521W_d YDR521W hom 0.000115332289078405 0.994673492259307 1973 Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol Unknown Unknown Unknown
YHR180W_d YHR180W hom 0.000113642657478122 0.994749175937842 1974 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL092W_p YIL092W hom FT NUCLEUS 0.000112570660028584 0.994798706545883 1975 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus biological_process molecular_function nucleus|cytoplasm
YBL087C RPL23A hom FT TRANSLATION|RIBOSOME 0.000109833055330376 0.994947945001652 1976 Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPL189C-A COA2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION 0.000109218090296589 0.99495360892469 1977 Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p mitochondrial respiratory chain complex IV assembly molecular_function mitochondrial matrix
YKL066W_d YKL066W hom 0.000107147164029101 0.995049294249837 1978 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1 Unknown Unknown Unknown
YNL188W KAR1 het FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON 0.000105707628503486 0.995120906925414 1979 Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p karyogamy involved in conjugation with cellular fusion|spindle pole body duplication associated with nuclear envelope protein binding half bridge of spindle pole body
YKL117W SBA1 hom FT NUCLEUS 0.000101883904624281 0.995293180760447 1980 Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress protein folding|positive regulation of telomere maintenance via telomerase|regulation of telomerase activity chaperone binding nucleus|cytoplasm
YDR235W PRP42 het FT RNA PROCESSING|NUCLEUS 0.000101288858291557 0.995320670316793 1981 U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats mRNA splicing, via spliceosome RNA binding U1 snRNP|U2-type prespliceosome
YDR037W KRS1 het FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION 0.000101102136539668 0.995328599825574 1982 Lysyl-tRNA synthetase lysyl-tRNA aminoacylation lysine-tRNA ligase activity cytoplasm
YGR001C_p YGR001C hom 0.000100348780852366 0.995366865835178 1983 Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae biological_process methyltransferase activity cytoplasm
YJR146W_p YJR146W hom 9.63141562276796e-05 0.995549824967224 1984 Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2 biological_process molecular_function cellular_component
YDR097C MSH6 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 9.42492759545557e-05 0.995645231362243 1985 Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p mismatch repair|meiotic mismatch repair guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity|single base insertion or deletion binding|ATP binding MutSalpha complex|nucleus
YBR274W CHK1 hom FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS 9.35683084853378e-05 0.995676695016833 1986 Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase protein phosphorylation|replication fork protection|DNA damage checkpoint protein serine/threonine kinase activity nucleus
YDR421W ARO80 hom FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS 9.2448193252582e-05 0.995728449219956 1987 Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids aromatic amino acid family catabolic process|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|nucleic acid binding transcription factor activity nucleus
YDL012C YDL012C hom FT PLASMA MEMBRANE 9.21791431174873e-05 0.995740880510899 1988 Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication biological_process molecular_function plasma membrane
YMR034C_p YMR034C hom 8.78529462726361e-05 0.995940769833597 1989 Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene biological_process sterol transporter activity integral to membrane
YBL084C CDC27 het FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX 8.67906521634995e-05 0.995991646633878 1990 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YDR051C DET1 hom FT NUCLEUS 8.21989561513411e-05 0.996202009427826 1991 Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel intracellular sterol transport|dephosphorylation acid phosphatase activity nucleus|cytoplasm
YIL147C SLN1 het FT SIGNALING|PROTEIN PHOSPHORYLATION|PLASMA MEMBRANE 8.03152702160024e-05 0.996289597555489 1992 Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators negative regulation of protein kinase activity|protein autophosphorylation|peptidyl-histidine phosphorylation|osmosensory signaling pathway via two-component system osmosensor activity|protein histidine kinase activity|histidine phosphotransfer kinase activity plasma membrane|integral to plasma membrane
YPL152W-A_p YPL152W-A hom 8.01270399617373e-05 0.996297741312303 1993 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YLR386W VAC14 hom FT PROTEIN LOCALIZATION|LIPID METABOLISM 7.79025350210523e-05 0.996400523545417 1994 Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p phosphatidylinositol biosynthetic process|positive regulation of kinase activity protein binding, bridging fungal-type vacuole membrane|PAS complex|extrinsic to vacuolar membrane
YPR025C CCL1 het FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|NUCLEUS|MITOCHONDRION|RNA POL II, HOLOENZYME 7.76509093285658e-05 0.996412149799214 1995 Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters phosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity|cyclin-dependent protein kinase regulator activity mitochondrion|holo TFIIH complex|TFIIK complex
YDL237W AIM6 hom 7.41406912982354e-05 0.996574337948615 1996 Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene biological_process molecular_function cellular_component
YDR327W_d YDR327W het 7.3013499481377e-05 0.996626419403297 1997 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1 Unknown Unknown Unknown
YOR286W RDL2 hom FT MITOCHONDRION 7.15145267510035e-05 0.996695678871123 1998 Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss biological_process thiosulfate sulfurtransferase activity mitochondrion
YOR364W_d YOR364W hom 6.88608504283528e-05 0.996818291042213 1999 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C Unknown Unknown Unknown
YOL024W_p YOL024W hom 6.80143992300384e-05 0.996857401034849 2000 Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YDR459C PFA5 hom FT PLASMA MEMBRANE 6.60839688775274e-05 0.996946595947436 2001 Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain protein palmitoylation palmitoyltransferase activity integral to membrane|plasma membrane
YML023C NSE5 het FT RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME 5.825211705492e-05 0.997308865848473 2002 Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair DNA repair molecular_function Smc5-Smc6 complex|nucleus
YNL104C LEU4 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION 5.56085949751001e-05 0.99743060786054 2003 Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication leucine biosynthetic process 2-isopropylmalate synthase activity mitochondrion|cytoplasm
YGR025W_d YGR025W hom 5.27032036168899e-05 0.997565940351427 2004 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL134W PCL10 hom FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY 5.22703073341185e-05 0.997584852775504 2005 Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate negative regulation of glycogen biosynthetic process|regulation of cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YDR497C ITR1 hom FT PLASMA MEMBRANE 5.22670508152507e-05 0.997585003242355 2006 Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress myo-inositol transport|transmembrane transport myo-inositol transmembrane transporter activity integral to membrane|plasma membrane|membrane
YKL179C COY1 hom FT VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS 5.14248667350752e-05 0.99762391620439 2007 Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function Golgi vesicle transport molecular_function Golgi membrane
YDR297W SUR2 hom FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 5.09823564005589e-05 0.99764436231607 2008 Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis sphingolipid metabolic process sphingosine hydroxylase activity integral to membrane|endoplasmic reticulum membrane
YJR100C AIM25 hom FT MITOCHONDRION 5.04776281016364e-05 0.997669074585393 2009 Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YDR430C CYM1 hom FT PROTEOLYSIS|MITOCHONDRION 5.04279582551889e-05 0.997669978186427 2010 Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology proteolysis|proteolysis involved in cellular protein catabolic process metalloendopeptidase activity mitochondrion|mitochondrial intermembrane space
YOR270C VPH1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS 4.99032295468883e-05 0.997694566999072 2011 Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress polyphosphate metabolic process|proton transport|protein complex assembly|vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YNR052C POP2 hom FF|FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS|SITE OF POLARIZED GROWTH 4.94830768016257e-05 0.997713636275976 2012 RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter 3'-5'-exoribonuclease activity CCR4-NOT core complex|mating projection tip|cytoplasmic mRNA processing body|cytoplasm
YOR199W_d YOR199W hom 4.70634193801418e-05 0.99782705788917 2013 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL187C FAT3 hom FT MITOCHONDRION 4.62203693615983e-05 0.997866938015973 2014 Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion|integral to membrane
YKR032W_d YKR032W hom 4.56969890101573e-05 0.997890776709857 2015 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR138C TPO2 hom FT PLASMA MEMBRANE 4.54321199868078e-05 0.997902062444403 2016 Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication spermine transport spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|plasma membrane
YOR289W_p YOR289W hom FT NUCLEUS 4.50416997730009e-05 0.9979219547109 2017 Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YCR083W TRX3 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION 4.31904587326579e-05 0.998004385809763 2018 Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p cellular response to oxidative stress disulfide oxidoreductase activity mitochondrion
YKL024C URA6 het FT NUCLEOTIDE METABOLISM|NUCLEUS 4.29716694222209e-05 0.998014494944101 2019 Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP) 'de novo' pyrimidine nucleobase biosynthetic process|nucleobase-containing compound metabolic process uridylate kinase activity|adenylate kinase activity nucleus|cytoplasm
YDL046W NPC2 hom 4.18922883445611e-05 0.998065811153962 2020 Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes intracellular sterol transport molecular_function fungal-type vacuole lumen|fungal-type vacuole
YOR036W PEP12 hom FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|GOLGI APPARATUS 4.09256844822489e-05 0.99810931141298 2021 Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin Golgi to vacuole transport|vacuole inheritance SNAP receptor activity endosome|Golgi apparatus
YLR323C CWC24 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS 4.08629853515681e-05 0.998111926459492 2022 Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p generation of catalytic spliceosome for first transesterification step|snoRNA splicing molecular_function nucleus|U2-type spliceosomal complex
YGR174W-A_p YGR174W-A hom 3.9935438492164e-05 0.998156710497494 2023 Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis biological_process molecular_function cellular_component
YGL249W ZIP2 hom FT CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME 3.96083479300035e-05 0.998170715632535 2024 Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress synaptonemal complex assembly|synapsis|reciprocal meiotic recombination molecular_function synaptonemal complex
YLR016C PML1 hom FT RNA PROCESSING|RNA LOCALIZATION|NUCLEUS 3.89009715626208e-05 0.99820284912697 2025 Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p mRNA export from nucleus|mRNA splicing, via spliceosome|maintenance of RNA location molecular_function RES complex|nucleus|cytoplasm
YDL222C FMP45 hom FT CELL WALL ORG/BIOGENESIS|MITOCHONDRION|PLASMA MEMBRANE 3.80009301607706e-05 0.998245738896238 2026 Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C fungal-type cell wall organization|ascospore formation molecular_function cell cortex|mitochondrion|integral to membrane|plasma membrane
YGR077C PEX8 hom FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION 2.79641337535218e-05 0.998707917036509 2027 Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p protein targeting to peroxisome|peroxisome organization peroxisome targeting sequence binding peroxisomal matrix|peroxisomal membrane|extrinsic to intraperoxisomal membrane
YMR204C INP1 hom FT PEROXISOME ORGANIZATION 2.7392312894628e-05 0.998734526721781 2028 Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane peroxisome inheritance molecular_function peroxisome|extrinsic to intraperoxisomal membrane
YGL260W_p YGL260W hom 2.47858811787234e-05 0.998854938872382 2029 Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium biological_process molecular_function cellular_component
YGL091C NBP35 het FT RNA PROCESSING|COFACTOR METABOLISM|NUCLEUS 2.31597688966394e-05 0.998929902595959 2030 Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases iron-sulfur cluster assembly|tRNA wobble uridine modification 4 iron, 4 sulfur cluster binding|ATPase activity|iron ion binding mitochondrion|nucleus|cytoplasm
YGR199W PMT6 hom FT CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 2.26446461340144e-05 0.998954328023989 2031 Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases protein O-linked glycosylation|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane
YFL027C GYP8 hom FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM 2.25203486056809e-05 0.998959447001313 2032 GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport vesicle-mediated transport Rab GTPase activator activity intracellular
YNL161W CBK1 het FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH 2.14185552082402e-05 0.999010502917649 2033 Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress regulation of fungal-type cell wall organization|establishment or maintenance of cell polarity|protein phosphorylation|establishment or maintenance of actin cytoskeleton polarity|budding cell apical bud growth|Unknown protein serine/threonine kinase activity incipient cellular bud site|cellular bud|cellular bud neck|cellular bud tip|cytoplasm|cell cortex|nucleus|mating projection tip
YPL233W NSL1 het FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE 2.06859007411779e-05 0.999044207646304 2034 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation chromosome segregation molecular_function nuclear MIS12/MIND type complex|kinetochore|spindle pole
YJL001W PRE3 het FT PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM 1.67664283895727e-05 0.999225306861506 2035 Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process endopeptidase activity nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YLR129W DIP2 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS 1.62066642328506e-05 0.999251170767155 2036 Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) snoRNA binding small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YPR056W TFB4 het FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME 1.60051406556179e-05 0.999260482165238 2037 Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YLR042C_p YLR042C hom 1.49680313463633e-05 0.999308401808598 2038 Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene biological_process molecular_function fungal-type cell wall
YKL097C_d YKL097C hom 1.37958631354735e-05 0.999362656900297 2039 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species Unknown Unknown Unknown
YHL040C ARN1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE 1.2362535378612e-05 0.999428788779815 2040 ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress siderophore transport siderophore transmembrane transporter activity endosome|integral to membrane|plasma membrane|cytoplasmic membrane-bounded vesicle
YKR063C LAS1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION 1.05614928913912e-05 0.999512078740782 2041 Protein required for pre-rRNA processing at both ends of ITS2; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S transition of the cell cycle; human ortholog is Las1L; mutants require the SSD1-v allele for viability maturation of LSU-rRNA|maturation of 5.8S rRNA molecular_function mitochondrion|nucleus|preribosome|cytoplasm
YKL201C MNN4 hom FT CARBOHYDRATE METABOLISM 6.8089178505663e-06 0.999685393781632 2042 Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication protein O-linked glycosylation|protein N-linked glycosylation|response to stress molecular_function membrane
YDR461W MFA1 hom FT SIGNALING|PLASMA MEMBRANE 5.92353285317969e-06 0.999726670531375 2043 Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2 pheromone-dependent signal transduction involved in conjugation with cellular fusion mating pheromone activity extracellular region
YLL017W YLL017W hom FT SIGNALING 5.41698736245209e-06 0.999749707962021 2044 Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication Ras protein signal transduction Ras guanyl-nucleotide exchange factor activity membrane
YLR401C DUS3 hom FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS|NUCLEUS 2.759693398333e-06 0.99987248829524 2045 Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress tRNA modification tRNA dihydrouridine synthase activity nucleus|cytoplasm
YOR296W_p YOR296W hom -2.57601554446954e-06 0.999881046141792 2046 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene biological_process molecular_function cytoplasm
YPL012W RRP12 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|RIBOSOME -2.85373775906102e-06 0.999868142973162 2047 Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosome biogenesis molecular_function ribosome|nucleus|90S preribosome
YLR400W_d YLR400W hom -3.05102978890773e-06 0.999859027089921 2048 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL151C YKL151C hom FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM -3.38209897345936e-06 0.999843799944134 2049 NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress nicotinamide nucleotide metabolic process ATP-dependent NAD(P)H-hydrate dehydratase activity cytoplasm
YER030W CHZ1 hom FT CHROMATIN ORGANIZATION|NUCLEUS -7.22612394913961e-06 0.999666116764579 2050 Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress chromatin remodeling histone binding chromatin assembly complex|nucleus
YBL065W_d YBL065W hom -8.82721327456546e-06 0.999594211251061 2051 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene Unknown Unknown Unknown
YGL243W TAD1 hom FT RNA PROCESSING|NUCLEUS -9.37922859527481e-06 0.999566632519919 2052 tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala tRNA modification tRNA-specific adenosine-37 deaminase activity nucleus
YOR266W PNT1 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION -9.80498241257687e-06 0.999546960556743 2053 Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine protein insertion into mitochondrial membrane from inner side molecular_function mitochondrion|integral to mitochondrial inner membrane
YBR210W ERV15 hom FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION -1.04147418791949e-05 0.999518858362817 2054 Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport|axial cellular bud site selection molecular_function integral to membrane|ER to Golgi transport vesicle
YMR140W SIP5 hom FT RESPONSE TO NUTRIENT LEVELS -1.19998785098361e-05 0.999445545345709 2055 Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress cellular response to glucose starvation molecular_function cytoplasm
YDL083C RPS16B hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME -1.35511207492522e-05 0.999374337124689 2056 Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YDR206W EBS1 hom FT TRANSLATION|NUCLEUS|CHROMOSOME -1.60672839890549e-05 0.999257721529064 2057 Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay molecular_function cytoplasmic mRNA processing body|cytoplasm
YPL076W GPI2 het FT LIPID METABOLISM|ENDOPLASMIC RETICULUM -1.73732296089663e-05 0.999197868259383 2058 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein GPI anchor biosynthetic process phosphatidylinositol N-acetylglucosaminyltransferase activity glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane|endoplasmic reticulum
YLL054C_p YLL054C hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS -2.00161374338982e-05 0.999075154055867 2059 Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene biological_process sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity cellular_component
YDR063W AIM7 hom FT CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON -2.09250929096192e-05 0.999033155773953 2060 Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss actin filament debranching|negative regulation of Arp2/3 complex-mediated actin nucleation molecular_function nucleus|actin cortical patch|cytoplasm
YJL007C_d YJL007C hom -2.11202212714759e-05 0.999024722037951 2061 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR179C YLR179C hom FT NUCLEUS -2.25426345329884e-05 0.998958417280338 2062 Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus biological_process molecular_function nucleus|cytoplasm
YHR131C_p YHR131C hom -2.49467283481099e-05 0.998848367787931 2063 Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study biological_process molecular_function cytoplasm
YPR177C_d YPR177C het -2.55086289764172e-05 0.998821549306392 2064 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex Unknown Unknown Unknown
YIL158W AIM20 hom FT CELL CYCLE -2.74396490062234e-05 0.998732150836741 2065 Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress biological_process molecular_function fungal-type vacuole
YJR016C ILV3 het FT KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION -2.86521503918742e-05 0.998676127252524 2066 Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids branched-chain amino acid biosynthetic process dihydroxy-acid dehydratase activity mitochondrion
YJL208C NUC1 hom FT NUCLEUS|MITOCHONDRION -2.94552569255453e-05 0.998639019746732 2067 Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy DNA catabolic process|RNA catabolic process|apoptotic process|DNA recombination ribonuclease activity|endodeoxyribonuclease activity|exodeoxyribonuclease activity mitochondrion|mitochondrial inner membrane|nucleus
YJR128W_d YJR128W hom -3.06643249150092e-05 0.998583154813422 2068 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2 Unknown Unknown Unknown
YBL035C POL12 het FT ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME -3.10310217954631e-05 0.998566211601538 2069 B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation telomere capping|lagging strand elongation|DNA replication initiation DNA-directed DNA polymerase activity nuclear envelope|alpha DNA polymerase:primase complex|nucleus
YOR020W-A_p YOR020W-A hom FT MITOCHONDRION -3.24011849887433e-05 0.998502903282277 2070 Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YPL026C SKS1 hom FT TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION|NUCLEUS -3.27586739825477e-05 0.998486385523398 2071 Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway glucose transport|protein phosphorylation|response to glucose stimulus|positive regulation of transcription from RNA polymerase II promoter protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YMR104C YPK2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION|NUCLEUS -3.9268303495552e-05 0.998187232434061 2072 Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication eisosome assembly|protein phosphorylation protein kinase activity nucleus|cytoplasm
YMR096W SNZ1 hom FT COFACTOR METABOLISM -4.1097642773521e-05 0.998102500285459 2073 Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins pyridoxine metabolic process|thiamine biosynthetic process protein binding cellular_component
YPL019C VTC3 hom FT MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM -4.15978467470603e-05 0.998077972266327 2074 Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic molecular_function fungal-type vacuole membrane|integral to membrane|vacuolar transporter chaperone complex|endoplasmic reticulum
YJR011C_p YJR011C hom -4.35008804016672e-05 0.997990042813632 2075 Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS biological_process molecular_function cellular_component
YOL110W SHR5 hom FT PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM -4.36111543694277e-05 0.997984947618282 2076 Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization protein targeting to membrane|protein palmitoylation palmitoyltransferase activity endoplasmic reticulum palmitoyltransferase complex|extrinsic to endoplasmic reticulum membrane
YML074C FPR3 hom FT CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS -4.56805914552662e-05 0.99788964426273 2077 Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p meiotic recombination checkpoint peptidyl-prolyl cis-trans isomerase activity|macrolide binding nucleolus
YOR353C SOG2 het FT CELL CYCLE|SIGNALING|CELL DIVISION|SITE OF POLARIZED GROWTH -4.65656894639867e-05 0.997848433712637 2078 Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis signal transduction|cytokinetic cell separation|budding cell apical bud growth molecular_function incipient cellular bud site|cellular bud|mating projection tip|cytoplasm
YER068C-A_d YER068C-A hom -4.79504969604015e-05 0.997785440107339 2079 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR313C SPS4 hom FT CELL CYCLE -4.83207002440938e-05 0.997767343699803 2080 Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage ascospore formation molecular_function cellular_component
YKL127W PGM1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY -4.87403544505818e-05 0.997747953642809 2081 Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism glucose 6-phosphate metabolic process|galactose catabolic process|glucose 1-phosphate metabolic process|UDP-glucose metabolic process|trehalose biosynthetic process|glycogen biosynthetic process phosphoglucomutase activity cytoplasm
YMR019W STB4 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS -4.96082068232724e-05 0.997707854663855 2082 Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay; biological_process sequence-specific DNA binding|DNA binding nucleus
YLR226W BUR2 hom FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION|NUCLEUS -5.43088462926944e-05 0.997490662478213 2083 Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II phosphorylation of RNA polymerase II C-terminal domain|positive regulation of histone ubiquitination|transcription, DNA-dependent|positive regulation of histone H3-K4 methylation|mitotic sister chromatid segregation cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YEL004W YEA4 hom FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM -5.46149950820036e-05 0.997477645923031 2084 Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER fungal-type cell wall chitin biosynthetic process|UDP-N-acetylglucosamine transport|UDP-glucose transport|transmembrane transport UDP-N-acetylglucosamine transmembrane transporter activity integral to membrane|endoplasmic reticulum
YBR104W YMC2 hom FT MITOCHONDRION -5.69737649204326e-05 0.997367530482687 2085 Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication mitochondrial transport|transmembrane transport organic acid transmembrane transporter activity mitochondrion|integral to membrane
YLR178C TFS1 hom FT SIGNALING|PROTEOLYSIS -5.81267429869382e-05 0.99731425739684 2086 Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress regulation of Ras protein signal transduction|regulation of proteolysis lipid binding|peptidase inhibitor activity|phospholipid binding fungal-type vacuole lumen|fungal-type vacuole membrane|cytoplasm
YKL074C MUD2 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS -6.05315997901001e-05 0.997203141581266 2087 Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65 mRNA branch site recognition pre-mRNA branch point binding commitment complex
YIR010W DSN1 het FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE -6.05815832321639e-05 0.997200832109219 2088 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation chromosome segregation molecular_function nuclear MIS12/MIND type complex|kinetochore|spindle pole
YNL039W BDP1 het FT NUCLEUS -6.26605230411504e-05 0.997105206954977 2089 Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs DNA-dependent transcriptional open complex formation|positive regulation of transposon integration|RNA polymerase III transcriptional preinitiation complex assembly TFIIIC-class transcription factor binding|TFIIIB-type transcription factor activity transcription factor TFIIIB complex
YKL202W_d YKL202W hom -6.32071531712258e-05 0.99707951836087 2090 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR252W BTT1 hom FT PROTEIN LOCALIZATION|NUCLEUS -6.4259241363794e-05 0.997030906929492 2091 Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3 'de novo' cotranslational protein folding unfolded protein binding nascent polypeptide-associated complex|CCR4-NOT complex
YMR059W SEN15 het FT RNA PROCESSING|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION -6.43798524640069e-05 0.997025334129107 2092 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p tRNA-type intron splice site recognition and cleavage tRNA-intron endonuclease activity tRNA-intron endonuclease complex
YGR011W_d YGR011W hom -6.50091294426029e-05 0.99699625857389 2093 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL093C RSM25 hom FT TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME -6.62191394508345e-05 0.996940350433384 2094 Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YGR131W FHN1 hom FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PLASMA MEMBRANE -6.70152882954931e-05 0.996903564628905 2095 Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain establishment of protein localization to plasma membrane molecular_function integral to membrane|membrane raft
YDL082W RPL13A hom FT TRANSLATION|RIBOSOME -6.76340209240105e-05 0.996874976288877 2096 Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YJR022W LSM8 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS -7.45112409586225e-05 0.996557216850434 2097 Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA mRNA splicing, via spliceosome RNA binding U6 snRNP|nucleolus|nucleus|U4/U6 x U5 tri-snRNP complex
YNR073C_p YNR073C hom -7.73150372051699e-05 0.996429266852014 2098 Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p biological_process mannitol dehydrogenase activity cellular_component
YML113W DAT1 hom FT TRANSCRIPTION FROM RNA POL II|NUCLEUS -7.80796206190066e-05 0.996392341384167 2099 DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability negative regulation of transcription from RNA polymerase II promoter AT DNA binding nucleus
YML070W DAK1 hom FT CARBOHYDRATE METABOLISM -7.81099680825687e-05 0.996390939193156 2100 Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation response to stress|glycerol catabolic process glycerone kinase activity cytoplasm
YER159C BUR6 het FT TRANSCRIPTION FROM RNA POL II|NUCLEUS -7.94635658608011e-05 0.99632839682326 2101 Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter transcription coactivator activity|transcription corepressor activity nucleus|negative cofactor 2 complex
YNL013C_d YNL013C hom -8.18165925229671e-05 0.996220240026423 2102 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W Unknown Unknown Unknown
YAL034C-B_d YAL034C-B het -8.31826127970823e-05 0.996156560067769 2103 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YFR042W KEG1 het FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM -8.35408408990373e-05 0.996140008321771 2104 Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability chromosome organization|(1->6)-beta-D-glucan biosynthetic process molecular_function integral to endoplasmic reticulum membrane|integral to membrane
YGR254W ENO1 hom FT MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION -8.52657448026804e-05 0.996062072622724 2105 Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress regulation of vacuole fusion, non-autophagic|gluconeogenesis|glycolysis phosphopyruvate hydratase activity mitochondrion|phosphopyruvate hydratase complex|plasma membrane|fungal-type vacuole|cytoplasm
YDL174C DLD1 hom FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION -8.57243415519531e-05 0.996039120828461 2106 D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane cellular carbohydrate metabolic process|aerobic respiration D-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial inner membrane
YOR261C RPN8 het FT PROTEOLYSIS -8.57353363156911e-05 0.996038612821374 2107 Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p ubiquitin-dependent protein catabolic process molecular_function proteasome storage granule|proteasome regulatory particle, lid subcomplex
YDR365C ESF1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS -8.67152065448096e-05 0.9959969243409 2108 Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels rRNA processing RNA binding nucleolus|nucleus
YJR067C YAE1 het FT NUCLEUS -9.1763592539257e-05 0.995760080763981 2109 Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species biological_process molecular_function nucleus|cytoplasm
YOL082W ATG19 hom FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT -9.24055416162451e-05 0.995734878296622 2110 Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles vesicle organization|ER-associated protein catabolic process|protein processing|protein complex localization|CVT pathway protein binding, bridging pre-autophagosomal structure|cytoplasm|CVT complex|extrinsic to membrane
YJR095W SFC1 hom FT ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION -9.26063966625234e-05 0.995723692146497 2111 Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization succinate transport|fumarate transport succinate:fumarate antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YGR207C CIR1 hom FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION -9.32115086865212e-05 0.995693180719842 2112 Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response biological_process molecular_function mitochondrion
YPL274W SAM3 hom FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE -9.57168504235962e-05 0.995577423071025 2113 High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p spermidine transport|putrescine transport|S-adenosylmethionine transport S-adenosylmethionine transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity integral to membrane|plasma membrane
YDR374C_p YDR374C hom -9.5995741926496e-05 0.995569830732466 2114 Putative protein of unknown function biological_process molecular_function cellular_component
YKL215C OXP1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM -9.95283320512148e-05 0.995401316276468 2115 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress glutathione metabolic process 5-oxoprolinase (ATP-hydrolyzing) activity cytoplasm
YER011W TIR1 hom -0.000102969603901727 0.995242314953173 2116 Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking response to stress structural constituent of cell wall fungal-type cell wall
YBR276C PPS1 hom FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|NUCLEUS -0.000103787471161857 0.995204526052 2117 Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle inactivation of MAPK activity|protein dephosphorylation|regulation of S phase of mitotic cell cycle protein tyrosine/serine/threonine phosphatase activity cellular_component
YKL173W SNU114 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEOTIDE METABOLISM|NUCLEUS -0.000105773141657559 0.995112779783318 2118 GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2 assembly of spliceosomal tri-snRNP|spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step GTP binding|GTPase activity|U5 snRNA binding U4/U6 x U5 tri-snRNP complex|U5 snRNP
YHL042W_p YHL042W hom -0.000105836540678463 0.995109850484868 2119 Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function cellular_component
YJR147W HMS2 hom FT NUCLEUS -0.000106719071943504 0.995069073876723 2120 Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication pseudohyphal growth molecular_function nucleus|cytoplasm
YAL059W ECM1 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|CELL WALL ORG/BIOGENESIS|NUCLEUS -0.000110039421456903 0.994915660061462 2121 Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm fungal-type cell wall organization|ribosomal large subunit export from nucleus molecular_function nucleolus|nucleus|preribosome, large subunit precursor
YNL014W HEF3 hom FT TRANSLATION|NUCLEOTIDE METABOLISM|RIBOSOME -0.000110922368663596 0.994874864297378 2122 Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication translational elongation ATPase activity|translation elongation factor activity cytosolic ribosome
YLL050C COF1 het FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON -0.000111743238440194 0.994837706624719 2123 Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes actin filament depolymerization|actin filament severing actin filament binding plasma membrane|actin cortical patch
YHR035W_p YHR035W hom FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM -0.000111837426985314 0.994832584882875 2124 Putative protein of unknown function; not an essential gene biological_process molecular_function cellular_component
YIR014W_p YIR014W hom -0.000113803724138198 0.994741734009931 2125 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene biological_process molecular_function fungal-type vacuole
YLR250W SSP120 hom -0.000113832882929312 0.99474038675648 2126 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YGR194C XKS1 hom FT CARBOHYDRATE METABOLISM -0.000114007628318842 0.994732312816825 2127 Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains xylulose catabolic process xylulokinase activity cytoplasm
YHR003C YHR003C hom FT MITOCHONDRION -0.000115547880609965 0.99466114699097 2128 Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion
YJL130C URA2 hom FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|MITOCHONDRION -0.000117667246586261 0.994563223862538 2129 Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP glutamine metabolic process|'de novo' pyrimidine nucleobase biosynthetic process|negative regulation of pyrimidine nucleobase metabolic process aspartate carbamoyltransferase activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity mitochondrion|integral to membrane|cytoplasm
YDR400W URH1 hom FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS -0.000120491044495355 0.994432753307516 2130 Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways pyrimidine-containing compound salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|pyrimidine nucleoside catabolic process|nicotinate nucleotide salvage ribosylpyrimidine nucleosidase activity|nicotinic acid riboside hydrolase activity|nicotinamide riboside hydrolase activity|uridine nucleosidase activity nucleus|cytoplasm
YOR010C TIR2 hom -0.000120627695196395 0.994426439512123 2131 Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis response to stress molecular_function fungal-type cell wall
YGL150C INO80 het FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME -0.000121717075803663 0.994376105891456 2132 ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription nucleosome positioning|histone exchange|transcription from RNA polymerase II promoter|DNA repair|nucleosome mobilization|chromatin remodeling|chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter ATPase activity|ATP-dependent 3'-5' DNA helicase activity Ino80 complex
YMR297W PRC1 hom FT PROTEOLYSIS|ENDOPLASMIC RETICULUM -0.000122323459613861 0.994348088610872 2133 Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family vacuolar protein catabolic process|phytochelatin biosynthetic process serine-type carboxypeptidase activity fungal-type vacuole lumen|endoplasmic reticulum|fungal-type vacuole|cytoplasm
YPL271W ATP15 hom FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION -0.00012637814681443 0.994175565632916 2134 Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YDR350C ATP22 hom FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION -0.000127563468236675 0.994108617112371 2135 Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrial inner membrane
YIR013C GAT4 hom FT NUCLEUS -0.000127582455720196 0.994113898491596 2136 Protein containing GATA family zinc finger motifs transcription, DNA-dependent sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YGL101W_p YGL101W hom FT NUCLEUS -0.00012776247316671 0.994096785434741 2137 Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p biological_process molecular_function nucleus|cytoplasm
YMR308C PSE1 het FT PROTEIN LOCALIZATION|CELL CYCLE|RNA LOCALIZATION|NUCLEUS -0.000128903018873214 0.994044087945298 2138 Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p mRNA export from nucleus|regulation of protein desumoylation|protein import into nucleus|regulation of mitosis protein transporter activity|nuclear localization sequence binding integral to membrane|nucleus|cytoplasm
YOL150C_d YOL150C hom -0.000129840751175834 0.994000761215243 2139 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL086W_p YDL086W hom FT MITOCHONDRION -0.00013033811870244 0.993981373593149 2140 Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene biological_process carboxymethylenebutenolidase activity mitochondrion|cytoplasm
YDL224C WHI4 hom -0.000131367109482984 0.993930237806119 2141 Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication regulation of cell size RNA binding cytoplasm
YNL092W_p YNL092W hom -0.000133626637220947 0.993825839339996 2142 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity cellular_component
YLL012W YEH1 hom FT LIPID METABOLISM -0.000134439596735254 0.993788277655447 2143 Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes sterol metabolic process sterol esterase activity integral to membrane|lipid particle
YEL060C PRB1 hom FT PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS -0.000136001740624943 0.993716100968278 2144 Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress vacuolar protein catabolic process|sporulation resulting in formation of a cellular spore|cellular response to starvation serine-type endopeptidase activity fungal-type vacuole lumen|fungal-type vacuole
YBR280C SAF1 hom FT PROTEOLYSIS|UBIQUITIN LIGASE COMPLEX -0.000137586826941931 0.993644760225159 2145 F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity SCF ubiquitin ligase complex
YAL043C PTA1 het FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS -0.000138663434654686 0.993593121213896 2146 Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII tRNA processing|termination of RNA polymerase II transcription, exosome-dependent|mRNA cleavage|termination of RNA polymerase II transcription, poly(A)-coupled|mRNA polyadenylation RNA binding mRNA cleavage factor complex|mRNA cleavage and polyadenylation specificity factor complex
YKL140W TGL1 hom FT LIPID METABOLISM -0.000139111834250815 0.993572403568691 2147 Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes cellular lipid metabolic process|sterol metabolic process lipase activity|sterol esterase activity integral to membrane|lipid particle
YAL054C ACS1 hom FT KETONE METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION -0.000140476817775892 0.993510304330534 2148 Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions acetate fermentation|histone acetylation|acetyl-CoA biosynthetic process acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity cytosol|mitochondrion|integral to membrane
YNL020C ARK1 hom FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON -0.000141533648237425 0.993461482359123 2149 Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication regulation of endocytosis|actin filament organization|protein phosphorylation|cytokinesis|actin cortical patch assembly protein serine/threonine kinase activity|protein kinase activity mating projection tip|actin cortical patch
YGR172C YIP1 het FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS -0.000142529530954411 0.993418422676739 2150 Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4 vesicle-mediated transport|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus molecular_function integral to membrane|ER to Golgi transport vesicle|integral to Golgi membrane|endoplasmic reticulum membrane
YPR136C_d YPR136C het -0.000143530462711694 0.993368247559929 2151 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9 Unknown Unknown Unknown
YMR247W-A_p YMR247W-A hom -0.000145395002702551 0.993285104931475 2152 Putative protein of unknown function biological_process molecular_function cellular_component
YNL312W RFA2 het FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME -0.000147570759852936 0.993181572153997 2153 Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress establishment of protein localization|telomere maintenance via telomerase|telomere maintenance via recombination|nucleotide-excision repair|DNA repair|mitotic recombination|heteroduplex formation|DNA unwinding involved in replication|reciprocal meiotic recombination|double-strand break repair via homologous recombination|DNA replication|protein ubiquitination double-stranded DNA binding|single-stranded DNA binding|sequence-specific DNA binding condensed nuclear chromosome|chromosome, telomeric region|DNA replication factor A complex
YHL043W ECM34 hom FT CELL WALL ORG/BIOGENESIS -0.000148129502206019 0.993155756394854 2154 Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins fungal-type cell wall organization molecular_function cellular_component
YOR303W CPA1 hom FT KETONE METABOLISM|AMINO ACID METABOLISM -0.000148599779719678 0.993134028011719 2155 Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader arginine biosynthetic process carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carbamoyl-phosphate synthase complex
YLR361C DCR2 hom FT CELL CYCLE|SIGNALING -0.000150320548175217 0.993055558444621 2156 Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START endoplasmic reticulum unfolded protein response|traversing start control point of mitotic cell cycle|protein dephosphorylation hydrolase activity, acting on ester bonds|phosphoprotein phosphatase activity|phosphoric ester hydrolase activity cellular_component
YLR118C YLR118C hom FT KETONE METABOLISM|LIPID METABOLISM|NUCLEUS -0.000151622147779713 0.992994384690856 2157 Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS protein deacylation palmitoyl-(protein) hydrolase activity nucleus|cytoplasm
YDR044W HEM13 het FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM -0.000151868910174372 0.99298612275781 2158 Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) heme biosynthetic process coproporphyrinogen oxidase activity cytosol
YMR229C RRP5 het FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS -0.00015302648764878 0.992930553902096 2159 RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) poly(U) RNA binding small-subunit processome|nucleolus|90S preribosome
YOR092W ECM3 hom FT CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM -0.000153026633499685 0.992952722831712 2160 Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication fungal-type cell wall organization ATPase activity integral to membrane|endoplasmic reticulum
YOR093C_p YOR093C hom FT NUCLEUS -0.000153953451808933 0.992887731575731 2161 Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents biological_process molecular_function integral to membrane
YDL123W SNA4 hom -0.00015732036477978 0.992731108956284 2162 Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated biological_process molecular_function fungal-type vacuole lumen|fungal-type vacuole membrane
YPL027W SMA1 hom FT MEMBRANE ORGANIZATION -0.000158821152669339 0.99266176791667 2163 Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p ascospore-type prospore membrane assembly molecular_function prospore membrane
YML051W GAL80 hom FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEUS -0.000158903633013289 0.99265905180573 2164 Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding negative regulation of kinase activity|galactose metabolic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity RNA polymerase II activating transcription factor binding|kinase inhibitor activity nucleus|cytoplasm
YNL023C FAP1 hom FT NUCLEUS -0.000161357201350004 0.992544594754573 2165 Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1 biological_process sequence-specific DNA binding transcription factor activity cytoplasm
YKR082W NUP133 hom FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE -0.000161504963358427 0.992537767705316 2166 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133 poly(A)+ mRNA export from nucleus|double-strand break repair|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|tRNA export from nucleus|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore outer ring
YDL054C MCH1 hom -0.000162015333424893 0.992515303247123 2167 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport transport monocarboxylic acid transmembrane transporter activity|transporter activity integral to membrane|membrane
YJL029C VPS53 hom FT PROTEIN LOCALIZATION|V