Strain	Gene	Zyg	FClass	FTerms	similarity score	p-value	rank	description	GOBP	GOMF	GOCC
YLR034C	SMF3	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	1	0	1	Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress	cellular iron ion homeostasis|iron ion transport	metal ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YHL045W_d	YHL045W	hom			0.265768738692374	2.30638772685501e-55	2	Putative protein of unknown function; not an essential gene	Unknown	Unknown	Unknown
YGL090W	LIF1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.234562635709634	3.55374475673571e-43	3	Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein	double-strand break repair via nonhomologous end joining	chromatin binding	DNA ligase IV complex|nuclear chromatin|nucleus
YDL155W	CLB3	hom	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.213353942377543	7.52322823589575e-36	4	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress	G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|cytoplasm
YPL246C	RBD2	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.199485380725046	1.82370675685927e-31	5	Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p	biological_process	molecular_function	COPI-coated vesicle|integral to membrane|Golgi apparatus
YML029W	USA1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX	0.197726726837922	6.48415372206197e-31	6	Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p	ER-associated protein catabolic process|mRNA splicing, via spliceosome|positive regulation of protein oligomerization	protein complex scaffold	Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YNL123W	NMA111	hom	FT	LIPID METABOLISM|PROTEOLYSIS|NUCLEUS	0.196905620723702	1.10089366793541e-30	7	Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases	apoptotic process|cellular lipid metabolic process|protein catabolic process|cellular response to heat	serine-type peptidase activity	nucleus
YIL009W	FAA3	hom	FT	KETONE METABOLISM|LIPID METABOLISM	0.195747804255112	2.44707848918091e-30	8	Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	long-chain fatty acid metabolic process	long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity	cellular_component
YLR040C_p	YLR040C	hom			0.194342474643405	6.53444028032797e-30	9	Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential	biological_process	molecular_function	fungal-type cell wall
YDL022W	GPD1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.185904539838602	1.90999143632202e-27	10	NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity	NADH oxidation|intracellular accumulation of glycerol	glycerol-3-phosphate dehydrogenase [NAD+] activity	cytosol|peroxisome|nucleus
YLR440C	SEC39	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.185409498228013	2.45482146730171e-27	11	Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope	retrograde vesicle-mediated transport, Golgi to ER|vesicle-mediated transport|ER-dependent peroxisome organization	molecular_function	Dsl1p complex|nuclear envelope|endoplasmic reticulum|peroxisome|endoplasmic reticulum membrane
YML046W	PRP39	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.171919463120128	1.11922788303469e-23	12	U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats	mRNA 5'-splice site recognition	pre-mRNA 5'-splice site binding	commitment complex|U1 snRNP|U2-type prespliceosome
YCR015C_p	YCR015C	hom			0.171258671808916	1.66236967452839e-23	13	Putative protein of unknown function; YCR015C is not an essential gene	biological_process	molecular_function	cellular_component
YOR014W	RTS1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CHROMOSOME SEGREGATION|NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON	0.169944384385455	3.688328081375e-23	14	B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A	mitotic cell cycle spindle orientation checkpoint|cellular protein localization|meiotic sister chromatid cohesion, centromeric|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|spindle pole body|condensed nuclear chromosome, centromeric region|cellular bud neck|cytoplasm
YLR317W_d	YLR317W	het			0.168825808785422	7.45972455822262e-23	15	Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C	Unknown	Unknown	Unknown
YOR271C_p	FSF1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.166127159346662	3.54785925173184e-22	16	Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis	biological_process	molecular_function	mitochondrion|integral to membrane
YKL034W	TUL1	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.142926990389611	8.8287985873846e-17	17	Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein ubiquitination	ubiquitin-protein ligase activity	integral to membrane|Golgi apparatus
YNL279W	PRM1	hom	FT	MEMBRANE ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.141732722237428	1.60927952896471e-16	18	Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p	plasma membrane fusion involved in cytogamy|response to pheromone	molecular_function	integral to membrane|mating projection tip
YHR134W	WSS1	hom	FT	RESPONSE TO DNA DAMAGE|ENDOMEMBRANE SYSTEM|NUCLEUS	0.141484742929866	1.79928093667783e-16	19	Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response	protein sumoylation|response to UV-B|response to UV-C|response to DNA damage stimulus	molecular_function	nuclear envelope
YPL113C_p	YPL113C	hom	FT	OXIDATION-REDUCTION PROCESS	0.13628331925592	2.20728357530982e-15	20	Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene	metabolic process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	cellular_component
YNL103W	MET4	het	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.136169603236608	2.32917037994159e-15	21	Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p	response to cadmium ion|sulfur amino acid metabolic process|response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity	nucleus
YGR018C_p	YGR018C	hom			0.135898650182192	2.64692825619828e-15	22	Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W	biological_process	molecular_function	cellular_component
YJR018W_d	YJR018W	hom			0.135576583543477	3.08045967336426e-15	23	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR243W	FMP43	hom	FT	MITOCHONDRION	0.134184961765907	5.90798360175624e-15	24	Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|mitochondrial membrane
YOR033C	EXO1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.126619484072065	1.81028316498788e-13	25	5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress	mismatch repair|telomeric 3' overhang formation|DNA double-strand break processing|meiotic DNA double-strand break processing|telomere maintenance|gene conversion at mating-type locus, DNA double-strand break processing	5'-3' exonuclease activity|5'-flap endonuclease activity	nucleus
YDL010W	GRX6	hom	FT	RESPONSE TO OXIDATIVE STRESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.109229862985417	2.23253327408049e-10	26	Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication	cellular response to oxidative stress	glutathione-disulfide reductase activity|iron ion binding|protein homodimerization activity|2 iron, 2 sulfur cluster binding	integral to membrane|Golgi apparatus|Golgi lumen|endoplasmic reticulum membrane|fungal-type vacuole|cis-Golgi network
YML025C	YML6	het	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.107597275917372	4.15444542522339e-10	27	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDR020C_p	DAS2	hom	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.104862409182491	1.1339507452376e-09	28	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases	biological_process	molecular_function	nucleus|cytoplasm
YGL114W_p	YGL114W	hom	FT	PROTEIN LOCALIZATION	0.0975279875021276	1.50240641432858e-08	29	Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters	transport	oligopeptide transporter activity	integral to membrane|membrane
YBL068W	PRS4	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM	0.0960624508474403	2.4636855806833e-08	30	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YHR005C-A	TIM10	het	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0935220452178484	5.70831006240694e-08	31	Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane	protein import into mitochondrial inner membrane	protein transporter activity|unfolded protein binding	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex|mitochondrial intermembrane space protein transporter complex
YER014W	HEM14	hom	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM|MITOCHONDRION	0.0932766181571882	6.18393733646437e-08	32	Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides	heme biosynthetic process	oxygen-dependent protoporphyrinogen oxidase activity	mitochondrion|mitochondrial inner membrane
YGR251W	NOP19	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0920422463250909	9.22041896165181e-08	33	Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleoplasm|nucleolus|nucleus|90S preribosome
YOR244W	ESA1	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.091526719050576	1.08780469461709e-07	34	Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy	DNA repair|histone acetylation|regulation of cell cycle|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|chromatin silencing at rDNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	H4 histone acetyltransferase activity|histone acetyltransferase activity	Piccolo NuA4 histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YPR048W	TAH18	het	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM|MITOCHONDRION	0.0915071609946728	1.09462986643743e-07	35	Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance	oxidation-reduction process|iron-sulfur cluster assembly	oxidoreductase activity, acting on NADH or NADPH	mitochondrion
YOR096W	RPS7A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS|RIBOSOME	0.089366773204039	2.15372162903992e-07	36	Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication	cytoplasmic translation|ribosome biogenesis	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YIR035C_p	YIR035C	hom	FT	OXIDATION-REDUCTION PROCESS	0.0881901225201704	3.14204781688475e-07	37	Putative cytoplasmic short-chain dehydrogenase/reductase	biological_process	molecular_function	integral to membrane|cytoplasm
YPL160W	CDC60	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.0881895543918885	3.10470851909978e-07	38	Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA	leucyl-tRNA aminoacylation|DNA replication initiation	leucine-tRNA ligase activity	cytoplasm
YDR242W	AMD2	hom			0.086283280792174	5.84590855334346e-07	39	Putative amidase	biological_process	amidase activity	cellular_component
YMR013W-A_d	YMR013W-A	hom			0.0844860030059505	9.52047791935605e-07	40	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73	Unknown	Unknown	Unknown
YJR082C	EAF6	hom	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0816042980852585	2.20623324549108e-06	41	Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3	DNA repair|histone acetylation	histone acetyltransferase activity	nucleus|NuA4 histone acetyltransferase complex|NuA3 histone acetyltransferase complex
YMR194W	RPL36A	hom	FT	TRANSLATION|RIBOSOME	0.0814326471626435	2.31748180306702e-06	42	Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YDR029W_d	YDR029W	hom			0.0811242463273581	2.75831592344014e-06	43	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR071W	YBR071W	hom	FT	SITE OF POLARIZED GROWTH	0.0800633398281133	3.43079498796715e-06	44	Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking	biological_process	molecular_function	cellular bud neck|cytoplasm
YIR011C	STS1	het	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|CHROMOSOME SEGREGATION|NUCLEUS	0.0792092623154165	4.37314738009199e-06	45	Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation	proteasome localization|chromosome segregation|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process	molecular_function	nucleus
YER174C	GRX4	hom	FT	ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0791960176713853	4.36059623217421e-06	46	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription is regulated by Yap5	cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization	disulfide oxidoreductase activity	nucleus
YGL227W	VID30	hom	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS	0.0783878401032511	5.4749707570054e-06	47	Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm	regulation of nitrogen utilization|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process	molecular_function	nucleus|GID complex|cytoplasm
YOR059C	YOR059C	hom	FT	LIPID METABOLISM	0.0780836530682831	5.93494100517486e-06	48	Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	lipid particle
YEL040W	UTR2	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.077704352555959	6.60746797506351e-06	49	Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck	cell wall chitin metabolic process|fungal-type cell wall organization	transferase activity, transferring glycosyl groups	cellular bud neck septin ring|fungal-type cell wall
YLR086W	SMC4	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0772672941189792	7.42231547522559e-06	50	Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate	mitotic chromosome condensation|mitotic sister chromatid segregation|tRNA gene clustering	chromatin binding|ATPase activity	SMC loading complex|nuclear condensin complex
YLR272C	YCS4	het	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0771076868225628	7.75205687007943e-06	51	Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation	maintenance of rDNA|meiotic chromosome condensation|mitotic chromosome condensation|tRNA gene clustering|mitotic sister chromatid segregation|chromatin silencing at silent mating-type cassette	molecular_function	nucleolus|nuclear condensin complex
YNL064C	YDJ1	hom	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	0.0770337957066461	7.9094105172498e-06	52	Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family	protein refolding|ER-associated protein catabolic process|protein targeting to mitochondrion|protein targeting to ER|'de novo' protein folding	unfolded protein binding|ATPase activator activity	cytosol|TRC complex|perinuclear region of cytoplasm
YIL139C	REV7	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0765341206868665	9.05640295204782e-06	53	Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair	error-prone translesion synthesis|error-free translesion synthesis	DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YDR255C	RMD5	hom	FT	KETONE METABOLISM|CELL CYCLE|CARBOHYDRATE METABOLISM|PROTEOLYSIS	0.0755672072995034	1.17422505649881e-05	54	Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	cytosol|GID complex
YKL079W	SMY1	hom	FT	VESICLE-MEDIATED TRANSPORT|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0732304713809339	2.17198047929236e-05	55	Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins	exocytosis	motor activity	incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YHR118C	ORC6	het	FT	GENE SILENCING|NUCLEUS|CHROMOSOME	0.0729992273879181	2.30604176076021e-05	56	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p	DNA replication initiation|pre-replicative complex assembly|chromatin silencing at silent mating-type cassette	DNA replication origin binding	pre-replicative complex|DNA replication preinitiation complex|nuclear origin of replication recognition complex
YEL057C_p	YEL057C	hom			0.0729781006773765	2.32518958697522e-05	57	Protein of unknown function involved in telomere maintenance; target of UME6 regulation	biological_process	molecular_function	cellular_component
YIL078W	THS1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION	0.072862976047624	2.38867887367579e-05	58	Threonyl-tRNA synthetase, essential cytoplasmic protein	cytoplasmic translation|threonyl-tRNA aminoacylation	threonine-tRNA ligase activity	mitochondrion|cytoplasm
YGR012W	YGR012W	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0725404676162569	2.5956488570685e-05	59	Putative cysteine synthase, localized to the mitochondrial outer membrane	cysteine biosynthetic process	cysteine synthase activity	mitochondrial outer membrane|mitochondrion
YMR097C	MTG1	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0725102760629584	2.66712050959417e-05	60	Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals	mitochondrial translation	GTPase activity	mitochondrion|mitochondrial inner membrane
YDR430C	CYM1	hom	FT	PROTEOLYSIS|MITOCHONDRION	0.0724739875267098	2.64038120750171e-05	61	Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology	proteolysis|proteolysis involved in cellular protein catabolic process	metalloendopeptidase activity	mitochondrion|mitochondrial intermembrane space
YOL120C	RPL18A	het	FF|FT	TRANSLATION|RIBOSOME	0.0723613910212127	2.71781997799313e-05	62	Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR205W	TDA10	hom	FT	NUCLEUS	0.0716941543686275	3.22289718168762e-05	63	ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele	biological_process	ATP binding	nucleus|cytoplasm
YBR297W	MAL33	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|NUCLEUS	0.0716466303759825	3.26208220531289e-05	64	MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C	cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent	sequence-specific DNA binding transcription factor activity	nucleus
YDL174C	DLD1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.071066161868344	3.778703278491e-05	65	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane	cellular carbohydrate metabolic process|aerobic respiration	D-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial inner membrane
YML083C	YML083C	hom			0.0710261874445466	3.8170002518863e-05	66	Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions	biological_process	molecular_function	cellular_component
YHR120W	MSH1	hom	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0708193411360968	4.02112108850921e-05	67	DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis	DNA repair|mismatch repair|mitochondrial DNA repair|mitochondrion organization|reciprocal meiotic recombination|mitochondrial genome maintenance	guanine/thymine mispair binding|dinucleotide insertion or deletion binding|DNA-dependent ATPase activity	mitochondrion
YNL145W	MFA2	hom	FT	SIGNALING|PLASMA MEMBRANE	0.0697388986510438	5.37628601361413e-05	68	Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YDR235W	PRP42	het	FT	RNA PROCESSING|NUCLEUS	0.0694999275629285	5.6021274812836e-05	69	U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats	mRNA splicing, via spliceosome	RNA binding	U1 snRNP|U2-type prespliceosome
YJR116W_p	TDA4	hom			0.0689428257544429	6.40974914086024e-05	70	Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	integral to membrane
YNR059W	MNT4	hom	FT	CARBOHYDRATE METABOLISM	0.068884714211509	6.51814159117417e-05	71	Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation	protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	cellular_component
YMR053C	STB2	hom	FT	NUCLEUS|CHROMOSOME	0.0688248089021224	6.64780956173672e-05	72	Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p	biological_process	molecular_function	Sin3-type complex
YBR146W	MRPS9	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0687259589058597	6.75962874498888e-05	73	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YER172C	BRR2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0686362120917551	6.90964109206141e-05	74	RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	ATP-dependent RNA helicase activity	U4/U6 x U5 tri-snRNP complex|U5 snRNP
YOR077W	RTS2	het	FT	NUCLEUS	0.0683503595710757	7.40870485184374e-05	75	Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication	biological_process	molecular_function	nucleus|cytoplasm
YIL121W	QDR2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0682705322060972	7.55404646917035e-05	76	Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper	drug transmembrane transport|potassium ion import	drug transmembrane transporter activity	integral to membrane|integral to plasma membrane
YLR023C	IZH3	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0681977614108178	7.76507967652893e-05	77	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity	cellular zinc ion homeostasis	metal ion binding	integral to membrane|endoplasmic reticulum|membrane
YOR339C	UBC11	hom			0.068166514869662	7.74747723831254e-05	78	Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2	protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YIL164C	NIT1	hom			0.0678735438817779	8.3380993964212e-05	79	Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene	biological_process	nitrilase activity	cellular_component
YPL026C	SKS1	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0677824972683729	8.50290795263159e-05	80	Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway	glucose transport|protein phosphorylation|response to glucose stimulus|positive regulation of transcription from RNA polymerase II promoter	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YNL313C	EMW1	het	FT	CELL WALL ORG/BIOGENESIS|NUCLEUS	0.0663671512995816	0.000119596734278317	81	Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress	fungal-type cell wall organization	molecular_function	nucleus|cytoplasm
YOL070C	NBA1	hom	FT	SITE OF POLARIZED GROWTH	0.0662861777320884	0.000121912893256436	82	Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate	biological_process	molecular_function	ribosome|cellular bud neck|cytoplasm
YGR189C	CRH1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.0661044817257076	0.000126969534130475	83	Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress	fungal-type cell wall organization|cell wall chitin metabolic process	transferase activity, transferring glycosyl groups	incipient cellular bud site|fungal-type cell wall
YNR070W_p	PDR18	hom	FT	NUCLEOTIDE METABOLISM|MITOCHONDRION	0.0660561132077335	0.000128428147193138	84	Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	transport	ATPase activity, coupled to transmembrane movement of substances	mitochondrion|integral to membrane|membrane
YDL164C	CDC9	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0657372709720873	0.00013844543930693	85	DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination	lagging strand elongation|base-excision repair|mitotic cell cycle|DNA ligation|DNA recombination|nucleotide-excision repair	DNA ligase (ATP) activity	mitochondrion|nucleus|replication fork
YOR141C	ARP8	hom	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME|CYTOSKELETON	0.0654385105306218	0.000148495497434885	86	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity	mitotic recombination|response to DNA damage stimulus|chromatin remodeling	mRNA binding|ATP-dependent 3'-5' DNA helicase activity	nucleus|Ino80 complex
YDR246W-A_p	YDR246W-A	hom			0.0653135491729092	0.000152899458243998	87	Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YJL186W	MNN5	hom	FT	CARBOHYDRATE METABOLISM|GOLGI APPARATUS	0.0650583934789397	0.000162276203919835	88	Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment	protein glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YER045C	ACA1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0649378748139403	0.000166890813632004	89	ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YNR061C	YNR061C	hom			0.0649304617390214	0.000167178647972906	90	Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YDL065C	PEX19	hom	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0649131516589316	0.000168986600984256	91	Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning	protein stabilization|protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization|protein exit from endoplasmic reticulum	peroxisome membrane targeting sequence binding|protein binding	cytosol|peroxisomal membrane|endoplasmic reticulum
YOR280C	FSH3	hom			0.0647617065079928	0.000173858705462842	92	Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2	biological_process	molecular_function	cellular_component
YMR273C	ZDS1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL WALL ORG/BIOGENESIS|RNA LOCALIZATION|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|SITE OF POLARIZED GROWTH|NUCLEAR PORE	0.0646570300161801	0.000178127495027594	93	Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication	mRNA export from nucleus|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|chromatin silencing|establishment of cell polarity|regulation of protein localization|cell aging	protein phosphatase type 2A regulator activity	incipient cellular bud site|nuclear pore|cellular bud neck|cellular bud tip|cytoplasm
YBR121C	GRS1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0640540967197416	0.000204696730927763	94	Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication	mitochondrial glycyl-tRNA aminoacylation|glycyl-tRNA aminoacylation|DNA-dependent transcription, termination	glycine-tRNA ligase activity	mitochondrion|cytoplasm
YGL136C	MRM2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION	0.0637862115201184	0.000217658061431373	95	Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ	rRNA methylation	rRNA (uridine-2'-O-)-methyltransferase activity	mitochondrion
YPL064C	CWC27	hom	FT	RNA PROCESSING|NUCLEUS	0.063686452339409	0.000222678666189484	96	Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	U2-type spliceosomal complex
YDR392W	SPT3	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0634724176484418	0.000233819395999382	97	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters	conjugation with cellular fusion|histone acetylation|pseudohyphal growth|ascospore formation|chromatin modification|invasive growth in response to glucose limitation|transcription from RNA polymerase II promoter	transcription cofactor activity	SLIK (SAGA-like) complex|SAGA complex
YOR016C	ERP4	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0634082331760034	0.000237260841435834	98	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane
YER156C_p	YER156C	hom	FT	NUCLEUS	0.0633387753814433	0.000241038522158411	99	Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1	biological_process	molecular_function	nucleus|cytoplasm
YBR145W	ADH5	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|NUCLEUS	0.0631462312505368	0.000251807655164122	100	Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication	NADH oxidation|ethanol biosynthetic process involved in glucose fermentation to ethanol|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	nucleus|cytoplasm
YLR112W_d	YLR112W	hom			0.0631215152920552	0.00025322225244226	101	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL044W	PEX15	hom	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0630848424439941	0.000255334925012291	102	Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly	protein import into peroxisome matrix, receptor recycling	protein anchor	integral to peroxisomal membrane
YBR131W	CCZ1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.0629978472073509	0.000260412868373281	103	Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway	autophagy|autophagic vacuole fusion|vacuolar transport|vesicle docking|protein targeting to vacuole	guanyl-nucleotide exchange factor activity	Mon1-Ccz1 complex|membrane
YKL072W	STB6	hom			0.0624383275293203	0.000295402774802743	104	Protein that binds Sin3p in a two-hybrid assay	biological_process	molecular_function	cellular_component
YOR336W	KRE5	het	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOPLASMIC RETICULUM	0.0622000870209648	0.000311598368080827	105	Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects	(1->6)-beta-D-glucan biosynthetic process	UDP-glucose:glycoprotein glucosyltransferase activity	endoplasmic reticulum
YLR380W	CSR1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|MITOCHONDRION	0.0619935063800132	0.000326310647089999	106	Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress	phosphatidylinositol metabolic process|Golgi to plasma membrane protein transport|Golgi to plasma membrane transport|Unknown|negative regulation of fatty acid biosynthetic process|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cytosol|endosome|mitochondrion|lipid particle
YJL030W	MAD2	hom	FT	CELL CYCLE|CELL DIVISION|ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|NUCLEAR PORE|KINETOCHORE	0.0616551361623452	0.000351820375551558	107	Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I	chromosome decondensation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	mitotic checkpoint complex|condensed nuclear chromosome kinetochore|nuclear pore
YLR368W	MDM30	hom	FT	MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION|MITOCHONDRION|UBIQUITIN LIGASE COMPLEX	0.0615537071771332	0.000359822992969048	108	F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|chronological cell aging|proteolysis involved in cellular protein catabolic process|mitochondrion organization|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of mRNA export from nucleus|mitochondrial fusion	ubiquitin-protein ligase activity	mitochondrion|SCF ubiquitin ligase complex
YBR010W	HHT1	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0613375924559336	0.000377444973352295	109	Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation	chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint	DNA binding	replication fork protection complex|nucleus|nuclear nucleosome
YDR486C	VPS60	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	0.0612864525979297	0.00038173128323918	110	Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p	late endosome to vacuole transport via multivesicular body sorting pathway|filamentous growth	molecular_function	fungal-type vacuole membrane|cytoplasm
YFL025C	BST1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.060870399359239	0.000427578415375719	111	GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules	protein retention in ER lumen|vesicle organization|ER-associated protein catabolic process|ER to Golgi vesicle-mediated transport|GPI anchor metabolic process	phosphatidylinositol deacylase activity	integral to membrane|endoplasmic reticulum
YHR065C	RRP3	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0604511079077995	0.000458510008371028	112	Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RNA-dependent ATPase activity|ATP-dependent RNA helicase activity	nucleolus
YER152C	YER152C	hom	FT	NUCLEUS	0.0601439208631122	0.000490200129869295	113	Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene	biological_process	2-aminoadipate transaminase activity	nucleus|cytoplasm
YLL036C	PRP19	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION	0.0600328623717945	0.000502151231324547	114	Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain	generation of catalytic spliceosome for first transesterification step	ubiquitin-protein ligase activity|first spliceosomal transesterification activity	mitochondrion|nucleus|Prp19 complex|cytoplasm|U2-type catalytic step 1 spliceosome
YDR357C_p	CNL1	hom			0.0600159429553626	0.000504971900490241	115	Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	BLOC-1 complex|cytoplasm
YEL058W	PCM1	het	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEUS	0.0594156699999933	0.000573665476734473	116	Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors	fungal-type cell wall chitin biosynthetic process	phosphoacetylglucosamine mutase activity	nucleus|cytoplasm
YGR061C	ADE6	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM	0.0589924896345482	0.000628059362172839	117	Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway	'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process	phosphoribosylformylglycinamidine synthase activity	cytoplasm
YLR413W_p	YLR413W	hom	FT	PLASMA MEMBRANE	0.058840575177996	0.000654805477399244	118	Putative protein of unknown function; YLR413W is not an essential gene	biological_process	molecular_function	integral to membrane
YJL127C	SPT10	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS	0.0587639980926418	0.000659386045172618	119	Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box	DNA repair|negative regulation of transcription from RNA polymerase II promoter|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	histone acetyltransferase activity|sequence-specific DNA binding	nucleus
YNL079C	TPM1	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.058750751442639	0.000661245997735105	120	Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication	vacuole inheritance|exocytosis|intracellular mRNA localization|filamentous growth|budding cell apical bud growth|mitochondrion inheritance|budding cell isotropic bud growth|actin polymerization or depolymerization|actin filament organization|pseudohyphal growth|vesicle-mediated transport|establishment of cell polarity|actin filament bundle assembly	actin lateral binding	cellular bud neck contractile ring|actin filament bundle
YGR266W	YGR266W	hom	FT	MITOCHONDRION|PLASMA MEMBRANE	0.0587069559828146	0.000667430054401073	121	Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|plasma membrane
YFL018C	LPD1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.058514893598117	0.000695189840249889	122	Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes	L-serine biosynthetic process|2-oxoglutarate metabolic process|leucine catabolic process|glycine catabolic process|isoleucine catabolic process|pyruvate metabolic process|valine catabolic process|hydrogen peroxide metabolic process	glycine dehydrogenase (decarboxylating) activity|pyruvate dehydrogenase activity|oxoglutarate dehydrogenase (succinyl-transferring) activity|dihydrolipoyl dehydrogenase activity	mitochondrial nucleoid|mitochondrion|glycine cleavage complex|mitochondrial oxoglutarate dehydrogenase complex
YOR298C-A	MBF1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION	0.0584712924425024	0.000702933455478416	123	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress	positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity	mitochondrion|nucleus
YNR044W	AGA1	hom			0.058448792185274	0.000704989320296251	124	Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YFL015C_d	YFL015C	hom			0.0584136795158311	0.000710246774262236	125	Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene	Unknown	Unknown	Unknown
YNL132W	KRE33	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0582263247272681	0.000738920423148617	126	Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance	ribosomal small subunit biogenesis	molecular_function	nucleolus|90S preribosome
YOR127W	RGA1	hom	FT	SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0579004740986374	0.000791364037605084	127	GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress	budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth	Rho GTPase activator activity	cellular bud neck split septin rings
YAL034C-B_d	YAL034C-B	het			0.0575986822089647	0.000842995549904036	128	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR285C	NGL2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0574922281407927	0.000863481249477037	129	Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication	rRNA processing	endoribonuclease activity	intracellular
YOR047C	STD1	hom	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM|NUCLEUS|PLASMA MEMBRANE	0.0567850905101016	0.000998152989113774	130	Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]	response to salt stress|signal transduction|nicotinamide riboside biosynthetic process|glucose metabolic process|nicotinic acid riboside biosynthetic process|regulation of transcription from RNA polymerase II promoter	protein kinase activator activity	plasma membrane|nucleus
YJR074W	MOG1	hom	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION|NUCLEUS	0.0567367249123528	0.00100991871101536	131	Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p	protein import into nucleus	Ran GTPase binding	nucleus
YLR088W	GAA1	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.056422522307058	0.00107547443718012	132	Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER	attachment of GPI anchor to protein	GPI-anchor transamidase activity	integral to membrane|GPI-anchor transamidase complex
YMR137C	PSO2	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0563820272436746	0.00108444593959608	133	Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress	DNA repair|double-strand break repair	damaged DNA binding|5'-3' exonuclease activity	nucleus
YLL056C_p	YLL056C	hom			0.0562321041071714	0.00112210356251759	134	Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin	biological_process	molecular_function	cellular_component
YMR008C	PLB1	hom	FT	LIPID METABOLISM|PLASMA MEMBRANE	0.0560040546080019	0.00117158411155167	135	Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol	glycerophospholipid metabolic process	lysophospholipase activity	periplasmic space|plasma membrane
YIR009W	MSL1	hom	FT	RNA PROCESSING|NUCLEUS	0.0558333091409864	0.00121303080097699	136	U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members	mRNA splicing, via spliceosome	U2 snRNA binding	U2 snRNP|U2-type prespliceosome
YBL096C_d	YBL096C	hom			0.0556354353126801	0.00126275413808438	137	Non-essential protein of unknown function	Unknown	Unknown	Unknown
YDR241W_d	BUD26	hom			0.0551461494536875	0.00139389087614503	138	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YDR310C	SUM1	hom	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING|NUCLEUS	0.0550754538163127	0.00141384398640253	139	Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint	negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter during mitosis|DNA replication initiation|chromatin silencing at silent mating-type cassette	DNA replication origin binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus
YPL125W	KAP120	hom	FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0549383889995758	0.00145328092594633	140	Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p	protein import into nucleus|transcription factor import into nucleus	protein transporter activity|structural constituent of nuclear pore	integral to membrane|nucleus|nuclear pore|cytoplasm
YJR150C	DAN1	hom			0.0548608373209201	0.00147604090096215	141	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth	sterol transport	molecular_function	fungal-type cell wall
YDR476C_p	YDR476C	hom	FT	ENDOPLASMIC RETICULUM	0.0542569198187283	0.00167285431741616	142	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YJL075C_d	APQ13	hom			0.0542027005085843	0.00168282544268389	143	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate	Unknown	Unknown	Unknown
YGL079W_p	KXD1	hom			0.0541715944071072	0.00169322855324775	144	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YGL147C	RPL9A	hom	FT	TRANSLATION|RIBOSOME	0.0536128559843414	0.00189045311935311	145	Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR467C_d	YDR467C	hom			0.0532914421690368	0.00201325041302138	146	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR013W	GAT3	hom	FT	NUCLEUS	0.0532812412833809	0.00201726487128591	147	Protein containing GATA family zinc finger motifs	transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YMR094W	CTF13	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|NUCLEUS|CHROMOSOME|KINETOCHORE	0.0531358924047573	0.00207526881445431	148	Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis	kinetochore assembly|septin ring assembly	DNA binding, bending|centromeric DNA binding	condensed nuclear chromosome kinetochore|CBF3 complex
YNR060W	FRE4	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|PLASMA MEMBRANE	0.0528310260501901	0.00220528928201442	149	Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels	siderophore transport	ferric-chelate reductase activity	integral to membrane|plasma membrane
YPR200C	ARR2	hom			0.052612316576358	0.00230059384935508	150	Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p	response to arsenic-containing substance	arsenate reductase activity	cellular_component
YHL014C	YLF2	hom	FT	MITOCHONDRION	0.0522320341105749	0.00247163553299028	151	Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	GTP binding	mitochondrion
YDR383C	NKP1	hom	FT	CELL CYCLE|CELL DIVISION|NUCLEUS|CHROMOSOME|KINETOCHORE	0.0520983610054391	0.0025358061404219	152	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4	biological_process	molecular_function	kinetochore
YOR062C_p	YOR062C	hom	FT	NUCLEUS	0.0519402543210723	0.00261367059587017	153	Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YNL256W	FOL1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.0518673441349691	0.00265030833137716	154	Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities	tetrahydrofolate biosynthetic process	dihydroneopterin aldolase activity|2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity|dihydropteroate synthase activity	mitochondrial envelope|mitochondrion|cytoplasm
YDR265W	PEX10	hom	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	0.0518228147712932	0.00267291473860689	155	Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders	protein import into peroxisome matrix|protein ubiquitination	ubiquitin-protein ligase activity|protein binding	peroxisomal membrane
YMR105C	PGM2	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0517416345124471	0.00273456751227228	156	Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress	glucose 6-phosphate metabolic process|cellular calcium ion homeostasis|galactose catabolic process|cellular cation homeostasis|glucose 1-phosphate metabolic process|trehalose biosynthetic process|UDP-glucose metabolic process|glycogen biosynthetic process	phosphoglucomutase activity	cytoplasm
YOL046C_d	YOL046C	hom			0.0517347826882854	0.0027181254721682	157	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W	Unknown	Unknown	Unknown
YCR106W	RDS1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0514877696827947	0.0028487386077246	158	Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide	response to xenobiotic stimulus	sequence-specific DNA binding|DNA binding	nucleus
YOR171C	LCB4	hom	FT	LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE	0.0514518879734542	0.00286818112124306	159	Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes	calcium-mediated signaling|sphingolipid metabolic process	D-erythro-sphingosine kinase activity	Golgi apparatus|endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum
YFL011W	HXT10	hom	FT	MITOCHONDRION|PLASMA MEMBRANE	0.0514185904651058	0.00288633162376117	160	Putative hexose transporter, expressed at low levels and expression is repressed by glucose	hexose transport|transmembrane transport	galactose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YKL044W_p	YKL044W	hom			0.050824866950808	0.00322806883768421	161	Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YDR236C	FMN1	het	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0506412918097836	0.0033740971525981	162	Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane	FMN biosynthetic process	riboflavin kinase activity|FMN adenylyltransferase activity	intracellular membrane-bounded organelle|mitochondrial inner membrane
YPR105C	COG4	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0504399420267349	0.003468904912321	163	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	peroxisome degradation|intra-Golgi vesicle-mediated transport|retrograde transport, vesicle recycling within Golgi|macroautophagy|CVT pathway	molecular_function	Golgi transport complex
YBR290W	BSD2	hom	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM	0.0501709112767251	0.0036468132903124	164	Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification	metal ion transport|ubiquitin-dependent protein catabolic process|protein targeting to vacuole	protein binding	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YHR163W	SOL3	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.050085491511141	0.00385650368720793	165	6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	6-phosphogluconolactonase activity	nucleus|cytoplasm
YML066C	SMA2	hom	FT	MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|ENDOPLASMIC RETICULUM	0.0500605758752912	0.00372214566429054	166	Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation	ascospore wall assembly|spore membrane bending pathway	molecular_function	integral to membrane|prospore membrane|cytoplasm
YJL127C-B_p	YJL127C-B	hom			0.0500243689952308	0.00377829168518361	167	Putative protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i>	biological_process	molecular_function	cellular_component
YMR269W	TMA23	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0499869839081038	0.0037731743211632	168	Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan	ribosomal small subunit biogenesis	molecular_function	ribosome|nucleolus
YER061C	CEM1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|MITOCHONDRION	0.0499853187753971	0.00377433624102507	169	Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration	fatty acid biosynthetic process	fatty acid synthase activity	mitochondrion
YPR201W	ARR3	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0499825406540813	0.00377627552137524	170	Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite	arsenite transport|antimonite transport	antiporter activity|arsenite transmembrane transporter activity|antimonite transmembrane transporter activity	integral to membrane|plasma membrane
YKR098C	UBP11	hom	FT	PROTEOLYSIS	0.0499167307319268	0.0038224799365219	171	Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins	biological_process	ubiquitin-specific protease activity	cellular_component
YHR152W	SPO12	hom	FT	CELL CYCLE|NUCLEUS	0.0495740634760937	0.00407146460629593	172	Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis	regulation of exit from mitosis|mitotic cell cycle|meiosis I	molecular_function	nucleolus|nucleus
YKR099W	BAS1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0495152039462795	0.00473816119340872	173	Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes	positive regulation of transcription from RNA polymerase II promoter	core promoter sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YJR010W	MET3	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.049514322533522	0.00411634932728095	174	ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process	sulfate adenylyltransferase (ATP) activity	mitochondrion|cytoplasm
YOR366W_d	YOR366W	hom			0.0494962643224608	0.00413000493872683	175	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C	Unknown	Unknown	Unknown
YKL171W	NNK1	hom	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION	0.0494232936992772	0.00418560475133188	176	Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm	proteolysis|protein phosphorylation	protein kinase activity	cytoplasm
YKL140W	TGL1	hom	FT	LIPID METABOLISM	0.0493915084577336	0.00421003497324793	177	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes	cellular lipid metabolic process|sterol metabolic process	lipase activity|sterol esterase activity	integral to membrane|lipid particle
YGR149W_p	YGR149W	hom			0.049360523712799	0.00423397430197745	178	Putative protein of unknown function; predicted to be an integal membrane protein	biological_process	molecular_function	integral to membrane
YLR408C_p	BLS1	hom			0.0492595419559348	0.00431863543483367	179	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene	biological_process	molecular_function	endosome|BLOC-1 complex
YJL033W	HCA4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0490897927555078	0.00446625635148583	180	DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis	rRNA processing	RNA-dependent ATPase activity|ATP-dependent RNA helicase activity	nucleolus
YOL037C_d	YOL037C	hom			0.0489775276836193	0.00454626727896182	181	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W	Unknown	Unknown	Unknown
YOR190W	SPR1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.0489522561390211	0.00456114200034211	182	Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance	ascospore formation	glucan exo-1,3-beta-glucosidase activity	fungal-type cell wall|ascospore wall
YML015C	TAF11	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0489005099913603	0.00461029387969051	183	TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors	RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter	chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	transcription factor TFIID complex
YJL193W_p	YJL193W	hom			0.0488039641536767	0.00471649047150198	184	Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect	biological_process	molecular_function	integral to membrane
YBR207W	FTH1	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	0.0487406614315456	0.00473956021372972	185	Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress	endocytosis|high-affinity iron ion transport	iron ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YPL074W	YTA6	hom			0.0482874089759185	0.00514316410255738	186	Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress	biological_process	ATPase activity	cell cortex
YGL087C	MMS2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|NUCLEUS	0.0482715181810791	0.00515786148346959	187	Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress	postreplication repair|response to DNA damage stimulus|protein polyubiquitination|free ubiquitin chain polymerization	ubiquitin-protein ligase activity	ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YKL062W	MSN4	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0480403420622841	0.00537600919116052	188	Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cellular response to acidity|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|replicative cell aging|age-dependent response to oxidative stress involved in chronological cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YGR154C	GTO1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0480003478703138	0.00541458337940503	189	Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization	glutathione metabolic process	glutathione transferase activity	peroxisome
YMR117C	SPC24	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE	0.0478825728137897	0.00553666858822294	190	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering	microtubule nucleation|chromosome segregation	structural constituent of cytoskeleton	Ndc80 complex|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region
YNL307C	MCK1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION	0.047871707237148	0.00554035620922186	191	Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family	meiosis|double-strand break repair via nonhomologous end joining|ascospore formation|protein phosphorylation|response to stress|mitotic sister chromatid segregation	protein serine/threonine/tyrosine kinase activity|protein serine/threonine kinase activity|protein kinase activity	cellular_component
YOR379C_d	YOR379C	hom			0.047542750365033	0.00591103552224457	192	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W	Unknown	Unknown	Unknown
YJR084W	YJR084W	hom	FT	RNA PROCESSING|SIGNALING|NUCLEUS|CHROMOSOME	0.0473418299837338	0.00608666749790556	193	Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|mRNA splicing, via spliceosome	molecular_function	transcriptionally active chromatin
YAL029C	MYO4	hom	FT	RNA LOCALIZATION|MITOCHONDRION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0472782770915567	0.00615534819281062	194	Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication	mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization	microfilament motor activity|actin filament binding	mitochondrion|filamentous actin|myosin V complex|cellular bud|cellular bud tip
YNR008W	LRO1	hom	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM	0.047222079595675	0.00621666030984275	195	Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase	lipid storage|triglyceride biosynthetic process	phospholipid:diacylglycerol acyltransferase activity	lipid particle|perinuclear endoplasmic reticulum
YLL014W	EMC6	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0471128024149152	0.00637670073130159	196	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|integral to membrane|endoplasmic reticulum
YJR083C	ACF4	hom			0.0470615626693014	0.00639482451199594	197	Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate	biological_process	molecular_function	cellular_component
YHL040C	ARN1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0469137099144305	0.00656298146031185	198	ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress	siderophore transport	siderophore transmembrane transporter activity	endosome|integral to membrane|plasma membrane|cytoplasmic membrane-bounded vesicle
YHR142W	CHS7	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0466344908901491	0.00694171055338859	199	Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress	protein folding|ER to Golgi vesicle-mediated transport|fungal-type cell wall chitin biosynthetic process	unfolded protein binding	integral to membrane|endoplasmic reticulum membrane
YGR174C	CBP4	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.046611966728699	0.00692693081421021	200	Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex	mitochondrial respiratory chain complex III assembly	molecular_function	mitochondrion|integral to mitochondrial membrane
YKL222C	YKL222C	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|CYTOSKELETON	0.046022542870029	0.00766339077254499	201	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine	biological_process	sequence-specific DNA binding	ribosome|nucleus|mitotic spindle
YDR174W	HMO1	hom	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.0460223263837841	0.00770913745702081	202	Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase	regulation of transcription from RNA polymerase I promoter|regulation of transcription by chromatin organization|regulation of ribosomal protein gene transcription from RNA polymerase II promoter	double-stranded DNA binding|four-way junction DNA binding|DNA binding, bending	nuclear chromatin|nucleolus|cytoplasm
YDL082W	RPL13A	hom	FT	TRANSLATION|RIBOSOME	0.0457751648173289	0.00799684201932492	203	Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YHL001W	RPL14B	hom	FT	TRANSLATION|RIBOSOME	0.0457657743100872	0.0080473533000926	204	Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YJR072C	NPA3	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION	0.0457065685459911	0.00809157716628596	205	Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress	cellular protein complex localization|nucleocytoplasmic transport|mitotic sister chromatid cohesion	ATPase activity|GTPase activity	cytoplasm
YLR238W	FAR10	hom	FT	CELL CYCLE|SIGNALING|ENDOPLASMIC RETICULUM	0.0456237900858284	0.00820723497145855	206	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	endoplasmic reticulum
YBR006W	UGA2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	0.0456193698327431	0.0082230183633222	207	Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm	cellular response to oxidative stress|gamma-aminobutyric acid catabolic process|glutamate decarboxylation to succinate	succinate-semialdehyde dehydrogenase [NAD(P)+] activity	cytoplasm
YLR011W	LOT6	hom	FT	PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0454826633251899	0.00840783009935141	208	FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions	cellular response to oxidative stress|cytoplasmic sequestering of transcription factor	NAD(P)H dehydrogenase (quinone) activity|transcription factor binding	cytosol|nucleus|cytoplasm
YKL109W	HAP4	hom	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.0454671211316971	0.0084301872879646	209	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex	regulation of cellular respiration|carbon catabolite activation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity	CCAAT-binding factor complex
YKL050C	YKL050C	hom			0.0452160430306703	0.00879879692335782	210	Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p	biological_process	molecular_function	cellular_component
YLR062C_d	BUD28	hom			0.0451969443187753	0.00882741636298468	211	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YKR066C	CCP1	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.045154692433467	0.00889102642503053	212	Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress	cellular response to oxidative stress	cytochrome-c peroxidase activity	mitochondrion|mitochondrial intermembrane space
YDL040C	NAT1	hom	FT	MITOCHONDRION|RIBOSOME	0.0451502063171582	0.00889780423256048	213	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	mitochondrion|NatA complex|cytosolic ribosome
YML101C	CUE4	hom	FT	ENDOPLASMIC RETICULUM	0.0451437140581776	0.00890762117107267	214	Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication	biological_process	molecular_function	endoplasmic reticulum|cytoplasm
YER065C	ICL1	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	0.0448842172091925	0.00930800980725511	215	Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose	glyoxylate cycle	isocitrate lyase activity	cellular_component
YOR261C	RPN8	het	FT	PROTEOLYSIS	0.0447200592061984	0.00956951095320854	216	Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p	ubiquitin-dependent protein catabolic process	molecular_function	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YMR195W	ICY1	hom			0.0446858234091987	0.00962486616412413	217	Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation	biological_process	molecular_function	fungal-type vacuole membrane
YLR451W	LEU3	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0446719672628408	0.00965816570604116	218	Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation	negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YHL002W	HSE1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	0.0446688028417757	0.00965249244654044	219	Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes	late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding	endosome|ESCRT-0 complex
YMR112C	MED11	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0445506262002934	0.00984626255629816	220	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	TFIIH-class transcription factor binding|TFIIH-class transcription factor recruiting transcription factor activity	core mediator complex
YMR031W-A_d	YMR031W-A	hom			0.0443393323095389	0.0102578996566431	221	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C	Unknown	Unknown	Unknown
YBR149W	ARA1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM	0.0442870960941646	0.0102908902473958	222	NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product	cellular carbohydrate metabolic process	alditol:NADP+ 1-oxidoreductase activity|D-arabinose 1-dehydrogenase [NAD(P)+] activity	cytosol
YDR285W	ZIP1	hom	FT	CELL CYCLE|NUCLEUS|CHROMOSOME	0.044285011337159	0.0102944777297142	223	Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate	synapsis|reciprocal meiotic recombination	chromatin binding|SUMO polymer binding	transverse filament
YDL004W	ATP16	het	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION	0.0442640437775017	0.0103306209473331	224	Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YER130C_p	YER130C	hom	FT	NUCLEUS	0.0442523666607763	0.0103965002836936	225	Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress	biological_process	sequence-specific DNA binding	cellular_component
YPL092W	SSU1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0442493684028853	0.0104246411444556	226	Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein	sulfite transport	sulfite transmembrane transporter activity	integral to membrane|plasma membrane
YOR010C	TIR2	hom			0.0438213948817546	0.0111204525155157	227	Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis	response to stress	molecular_function	fungal-type cell wall
YNL235C_d	YNL235C	hom			0.043793276331921	0.0111723902685831	228	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex	Unknown	Unknown	Unknown
YGL145W	TIP20	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0437638658699716	0.0112269446230957	229	Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p	retrograde vesicle-mediated transport, Golgi to ER	molecular_function	Dsl1p complex|endoplasmic reticulum
YJL152W_d	YJL152W	hom			0.043669431528335	0.011403715746271	230	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL241C	CIN2	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON	0.043635820241612	0.0114672259051403	231	GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2	protein folding|tubulin complex assembly|tubulin complex biogenesis	GTPase activator activity	cellular_component
YNL159C	ASI2	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS	0.0436040744773139	0.0115274990191628	232	Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals	ubiquitin-dependent protein catabolic process	molecular_function	nuclear inner membrane
YDL055C	PSA1	het	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.0433737849090582	0.0119732085533124	233	GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure	protein glycosylation|cell wall mannoprotein biosynthetic process|GDP-mannose biosynthetic process	mannose-1-phosphate guanylyltransferase activity	cytoplasm
YHR067W	HTD2	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0433464390692896	0.0120271360903261	234	Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology	fatty acid biosynthetic process	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	mitochondrion
YJL135W_d	YJL135W	hom			0.0431431221823285	0.0124348820578756	235	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3	Unknown	Unknown	Unknown
YDR090C_p	YDR090C	hom	FT	PLASMA MEMBRANE	0.0431355710316383	0.0124502585721526	236	Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YDL138W	RGT2	hom	FT	SIGNALING|PLASMA MEMBRANE	0.0431058961715614	0.0125108490711801	237	Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication	glucose transport|signal transduction|detection of glucose	glucose transmembrane transporter activity|receptor activity|glucose binding	integral to membrane|plasma membrane
YDL011C_d	YDL011C	hom			0.0430594117957554	0.0127257826773001	238	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W	Unknown	Unknown	Unknown
YDR352W	YPQ2	hom			0.0426216737511772	0.0135789344807047	239	Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YBR111W-A	SUS1	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE|HISTONE ACETYLTRANSFERASE	0.042616602937262	0.0136321014264034	240	Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP	poly(A)+ mRNA export from nucleus|regulation of protein localization|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone deubiquitination|histone H3-K4 methylation|transcription elongation from RNA polymerase II promoter|histone H3-K79 methylation|positive regulation of transcription from RNA polymerase II promoter	enzyme activator activity	DUBm complex|nucleoplasm|transcription export complex 2|SAGA complex|nuclear pore
YGL253W	HXK2	hom	FT	CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS|MITOCHONDRION	0.0425292294583202	0.0137412418119748	241	Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication	replicative cell aging|fructose import|regulation of transcription by glucose|glucose import|mannose metabolic process|glycolysis|glucose metabolic process|regulation of cell size|fructose metabolic process	hexokinase activity	cytosol|mitochondrion|nucleus
YKR019C	IRS4	hom	FF|FT	LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING|MITOCHONDRION	0.0424537607069481	0.0140527853822954	242	EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication	autophagy|fungal-type cell wall organization|chromatin silencing at rDNA|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation	molecular_function	mitochondrion|pre-autophagosomal structure
YKR036C	CAF4	hom	FT	TRANSCRIPTION FROM RNA POL II|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION|NUCLEUS|MITOCHONDRION	0.0424312651905349	0.0139605557618143	243	WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication	peroxisome fission|mitochondrial fission|regulation of transcription from RNA polymerase II promoter	molecular_function	mitochondrion|CCR4-NOT complex
YMR130W_p	YMR130W	hom			0.042307375324895	0.0142423287116096	244	Putative protein of unknown function; YMR130W is not an essential gene	biological_process	molecular_function	cellular_component
YDR108W	TRS85	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|GOLGI APPARATUS	0.0421726675699339	0.0145543858368281	245	Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role	meiosis|vesicle organization|piecemeal microautophagy of nucleus|ER to Golgi vesicle-mediated transport|peroxisome degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway	molecular_function	TRAPP complex|pre-autophagosomal structure
YGR085C	RPL11B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0421432120331871	0.0147270001271917	246	Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome	cytosolic large ribosomal subunit
YHR196W	UTP9	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|CHROMOSOME	0.0420604108368088	0.0148190210749684	247	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|rDNA heterochromatin|nucleolus|t-UTP complex|nucleus|90S preribosome
YNL115C_p	YNL115C	hom			0.0419093609414126	0.015181791797414	248	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YDR073W	SNF11	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RSC COMPLEX	0.0417993406338903	0.0155124462046445	249	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex
YLR410W	VIP1	hom	FT	CYTOSKELETON	0.0417531212518145	0.0155652284413658	250	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1	inositol phosphate biosynthetic process	inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 4-kinase activity|inositol hexakisphosphate 6-kinase activity	cytoplasm
YGL032C	AGA2	hom			0.0417104601639925	0.0157179938130446	251	Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YPL105C	SYH1	hom	FT	PROTEIN LOCALIZATION|MITOCHONDRION	0.0416006779703958	0.015947531663813	252	Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication	nuclear pore distribution	molecular_function	mitochondrion|ribosome|cytoplasmic mRNA processing body|extrinsic to membrane|cytoplasm
YBR164C	ARL1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0415997735425613	0.0159498242331063	253	Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor	Golgi to plasma membrane protein transport|vesicle-mediated transport|protein targeting to vacuole	GTPase activity	trans-Golgi network|cytosol|Golgi apparatus
YBR300C_d	YBR300C	hom			0.0415086471794704	0.0161823038976133	254	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene	Unknown	Unknown	Unknown
YJL134W	LCB3	hom	FT	LIPID METABOLISM|SIGNALING|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.04150527976522	0.0162705620996331	255	Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication	calcium-mediated signaling|sphingolipid biosynthetic process	sphingosine-1-phosphate phosphatase activity	integral to membrane|endoplasmic reticulum
YDR317W	HIM1	hom	FT	RESPONSE TO DNA DAMAGE	0.0413619164699282	0.0165628981016589	256	Protein of unknown function involved in DNA repair	DNA repair	molecular_function	cellular_component
YFR027W	ECO1	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0412689823538502	0.0168079977842907	257	Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress	double-strand break repair|regulation of DNA replication|mitotic chromosome condensation|internal peptidyl-lysine acetylation|establishment of mitotic sister chromatid cohesion|DNA repair|chromosome organization|DNA replication|regulation of mitosis|telomere organization|tRNA gene clustering	acetyltransferase activity|chromatin binding	nuclear chromatin|nuclear replication fork
YBL053W_d	YBL053W	hom			0.0412324481409749	0.0169052192739854	258	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR026C	NSI1	hom	FT	CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0412137690979401	0.0169715468545593	259	RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication	termination of RNA polymerase I transcription|chromatin silencing at rDNA|Unknown	DNA binding	ribosome|nucleolus|rDNA heterochromatin
YKR033C_d	YKR033C	hom			0.0412026132007466	0.0169849788647122	260	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80	Unknown	Unknown	Unknown
YJL055W_p	YJL055W	hom	FT	NUCLEUS	0.0411176862674763	0.0173137446126078	261	Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU	response to chemical stimulus|response to purine-containing compound	molecular_function	nucleus|cytoplasm
YFL003C	MSH4	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0411001332700191	0.0173281413296445	262	Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein	reciprocal meiotic recombination	DNA binding	nuclear chromosome
YPL257W_p	YPL257W	hom	FT	CELL CYCLE	0.0410954871260585	0.0172740924631731	263	Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene	biological_process	molecular_function	integral to membrane
YHR001W-A	QCR10	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0410497784807502	0.0173987590648437	264	Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|mitochondrial respiratory chain complex III
YOL036W_p	YOL036W	hom			0.0410277355858865	0.0174591606058475	265	Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDL006W	PTC1	hom	FF|FT	RNA PROCESSING|SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0410232396695526	0.0176571149557212	266	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation	mitochondrion inheritance|inactivation of MAPK activity involved in osmosensory signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|tRNA splicing, via endonucleolytic cleavage and ligation|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YDL141W	BPL1	het	FT	NUCLEUS	0.0409581149779492	0.0176511422072937	267	Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation	protein biotinylation	biotin-[pyruvate-carboxylase] ligase activity|biotin-[acetyl-CoA-carboxylase] ligase activity	nucleus|cytoplasm
YKR102W	FLO10	hom			0.0409547195906087	0.0176605522391138	268	Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth	filamentous growth of a population of unicellular organisms|flocculation via cell wall protein-carbohydrate interaction|flocculation|invasive growth in response to glucose limitation	mannose binding	fungal-type cell wall
YGL105W	ARC1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.040773963610042	0.01816788906036	269	Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress	positive regulation of ligase activity|tRNA aminoacylation for protein translation	enzyme activator activity|tRNA binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding	methionyl glutamyl tRNA synthetase complex|cytoplasm
YER060W	FCY21	hom			0.040450493526781	0.0191076857810847	270	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function	transmembrane transport	nucleobase transmembrane transporter activity	integral to membrane
YGR206W	MVB12	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT	0.0404037353686983	0.0192469906198932	271	ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin	negative regulation of protein complex assembly|protein targeting to vacuole|endosome transport via multivesicular body sorting pathway	ubiquitin binding	cytosol|endosome|ESCRT I complex
YBR138C_p	YBR138C	hom			0.0403676263296599	0.0193551752792611	272	Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene	biological_process	molecular_function	cytoplasm
YGL164C	YRB30	hom	FT	PROTEIN LOCALIZATION|NUCLEUS	0.0403361356731961	0.0194499562036173	273	RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes	biological_process	GTPase regulator activity	nucleus|cytoplasm
YBR187W_p	GDT1	hom			0.0403011845258331	0.0196468219475139	274	Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YDR411C	DFM1	hom	FT	SIGNALING|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX	0.0402442067551359	0.0197472861248695	275	Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p	endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process	molecular_function	Doa10p ubiquitin ligase complex|integral to membrane|endoplasmic reticulum|Hrd1p ubiquitin ligase ERAD-L complex
YBR088C	POL30	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0402297761065311	0.0197730811808568	276	Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair	lagging strand elongation|postreplication repair|base-excision repair|nucleotide-excision repair|mismatch repair|meiotic mismatch repair|leading strand elongation|chromatin silencing at telomere|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette	DNA polymerase processivity factor activity	PCNA complex|nucleus|replication fork
YPL073C_d	YPL073C	hom			0.0400169070258394	0.0204338846579639	277	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments	Unknown	Unknown	Unknown
YPL101W	ELP4	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.0398449138147659	0.020981780036582	278	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex|cytoplasm
YMR118C_p	SHH3	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0397298326396253	0.021355484506295	279	Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase	biological_process	molecular_function	integral to membrane
YDR130C	FIN1	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.0395351063447436	0.0220010254282526	280	Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress	intermediate filament cytoskeleton organization|mitotic cell cycle spindle checkpoint|mitotic spindle stabilization|mitotic sister chromatid segregation	microtubule binding|structural constituent of cytoskeleton	spindle microtubule|condensed nuclear chromosome kinetochore|intermediate filament|nucleus|spindle pole body|astral microtubule|spindle
YIL011W	TIR3	hom			0.039456397783096	0.0223266567028004	281	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth	biological_process	molecular_function	fungal-type cell wall
YPL008W	CHL1	hom	FT	CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS	0.039423938374693	0.0223971431183104	282	Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome	negative regulation of DNA recombination|chromosome segregation|donor selection|DNA replication initiation|mitotic sister chromatid cohesion	DNA helicase activity	nucleus
YJR112W	NNF1	het	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE	0.0393698823665676	0.0225620033407194	283	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation	chromosome segregation	molecular_function	nuclear MIS12/MIND type complex|kinetochore
YGR062C	COX18	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0393420642523874	0.0226576652195272	284	Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC	protein insertion into mitochondrial membrane from inner side	membrane insertase activity	integral to membrane|integral to mitochondrial inner membrane
YPL263C	KEL3	hom			0.0393268342344944	0.022710187822521	285	Cytoplasmic protein of unknown function	biological_process	molecular_function	cytoplasm
YCL010C	SGF29	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0392880751267467	0.0228443306722561	286	Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation	histone H3-K14 acetylation|cellular protein complex localization|histone H3-K18 acetylation|cellular protein localization|histone H3-K9 acetylation|positive regulation of transcription from RNA polymerase II promoter	methylated histone residue binding|RNA polymerase II transcription factor recruiting transcription factor activity	Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YPL111W	CAR1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS|SITE OF POLARIZED GROWTH	0.0392065398675206	0.0231287669191786	287	Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance	regulation of ornithine metabolic process|arginine catabolic process to ornithine	manganese ion binding|arginase activity|ornithine carbamoyltransferase inhibitor activity|zinc ion binding	cytosol|nucleus|mating projection tip|cytoplasm
YMR180C	CTL1	hom	FT	RNA PROCESSING|NUCLEUS	0.0391744983623512	0.0232413824243641	288	RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm	biological_process	polynucleotide 5'-phosphatase activity	nucleus|cytoplasm
YOR289W_p	YOR289W	hom	FT	NUCLEUS	0.0389893858651626	0.02411193135478	289	Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YDR535C_d	YDR535C	hom			0.0389375938661521	0.0240888885947488	290	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.	Unknown	Unknown	Unknown
YBL064C	PRX1	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.0388971603599635	0.0243422524063091	291	Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress	response to cadmium ion|cellular response to oxidative stress|cell redox homeostasis	thioredoxin peroxidase activity	mitochondrion
YLR277C	YSH1	het	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.038801207474254	0.0245888469424811	292	Putative endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog, SYC1, that arose from the whole genome duplication	termination of RNA polymerase II transcription|mRNA cleavage|mRNA polyadenylation|RNA splicing|snoRNA splicing|snoRNA 3'-end processing	endoribonuclease activity|RNA binding	mRNA cleavage factor complex|mRNA cleavage and polyadenylation specificity factor complex
YLR067C	PET309	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.038546750721741	0.0255456764871607	293	Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)	positive regulation of mitochondrial translational initiation|RNA metabolic process|mitochondrial respiratory chain complex IV biogenesis|aerobic respiration	translation regulator activity	extrinsic to mitochondrial inner membrane|mitochondrion|integral to membrane|mitochondrial inner membrane
YAR035W	YAT1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0384746715855347	0.0258224992888595	294	Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated	carnitine metabolic process|alcohol metabolic process	carnitine O-acetyltransferase activity	mitochondrion
YNL135C	FPR1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION	0.0384332902069012	0.0260493202938091	295	Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function	protein folding|chromatin organization|homoserine metabolic process	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	mitochondrion|nucleus|cytoplasm
YGR244C	LSC2	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0383259226668422	0.0264019820012934	296	Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate	tricarboxylic acid cycle|succinyl-CoA metabolic process	succinate-CoA ligase (ADP-forming) activity	mitochondrion
YDL233W_p	MFG1	hom	FT	NUCLEUS	0.0382728287273566	0.0266115232466406	297	Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YOR310C	NOP58	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0381403729320393	0.0272322604713616	298	Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	box C/D snoRNP complex|small-subunit processome|nucleolus|90S preribosome
YBL083C_d	YBL083C	hom			0.0380828819284831	0.0273729688241932	299	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3	Unknown	Unknown	Unknown
YGR259C_d	YGR259C	hom			0.0380665638775849	0.0275085261114698	300	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W	Unknown	Unknown	Unknown
YJR147W	HMS2	hom	FT	NUCLEUS	0.0378444876423724	0.0283551562592315	301	Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication	pseudohyphal growth	molecular_function	nucleus|cytoplasm
YNL124W	NAF1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0377663050763761	0.0286838102217342	302	RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p	box H/ACA snoRNP assembly	RNA binding	nucleoplasm|nucleus
YBL082C	ALG3	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0377539201365494	0.0287361721651825	303	Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins	oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation	alpha-1,3-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YML095C	RAD10	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.0377327770673678	0.0288257524777654	304	Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein	mitotic recombination|meiotic mismatch repair|DNA strand renaturation|nucleotide-excision repair, DNA incision, 5'-to lesion|removal of nonhomologous ends|double-strand break repair via single-strand annealing, removal of nonhomologous ends	single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity	nucleotide-excision repair factor 1 complex|nucleus
YDR151C	CTH1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|NUCLEUS	0.037685610046848	0.0290264591770289	305	Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis	nuclear-transcribed mRNA catabolic process|cellular iron ion homeostasis	mRNA binding	nucleus
YKL061W_p	BLI1	hom			0.0376085893342515	0.0294535463216329	306	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YMR160W	YMR160W	hom			0.037557028483415	0.0295797207370499	307	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress	biological_process	molecular_function	fungal-type vacuole membrane
YPL179W	PPQ1	hom	FT	TRANSLATION	0.0375210040663976	0.0297363432711267	308	Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors	protein dephosphorylation|regulation of translation	protein serine/threonine phosphatase activity	cytoplasm
YNL096C	RPS7B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS|RIBOSOME	0.0374789376551008	0.02992013606937	309	Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosome biogenesis	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit
YLL044W_d	YLL044W	hom			0.0374633281907665	0.029988583409438	310	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant	Unknown	Unknown	Unknown
YML122C_d	YML122C	hom	FF		0.0374295326244119	0.0304337344853894	311	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL122C_p	YNL122C	hom	FT	TRANSLATION|MITOCHONDRION	0.037428798094384	0.0302143218218617	312	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene	biological_process	molecular_function	mitochondrion
YKL162C_p	YKL162C	hom	FT	MITOCHONDRION	0.0373690786868581	0.0304047315256756	313	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion
YHR175W-A_p	YHR175W-A	hom			0.0373576518180737	0.0304555210521164	314	Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YEL022W	GEA2	hom	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|GOLGI APPARATUS	0.0372891109964813	0.0307616990067476	315	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication	retrograde vesicle-mediated transport, Golgi to ER|secretory granule organization|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization	ARF guanyl-nucleotide exchange factor activity	integral to membrane|Golgi cis cisterna|extrinsic to membrane
YER153C	PET122	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0372649889424099	0.0308700810366358	316	Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	translation initiation factor activity	mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YKR095W	MLP1	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON	0.0372058791722289	0.0311370514455362	317	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs	protein localization to nuclear pore|poly(A)+ mRNA export from nucleus|protein import into nucleus|transcriptional activation by promoter-terminator looping|nuclear retention of unspliced pre-mRNA at the site of transcription|telomere tethering at nuclear periphery	ribonucleoprotein complex binding	nucleoplasm|nuclear envelope|integral to membrane|ribonucleoprotein complex|spindle pole body
YPL099C	AIM43	hom	FT	MITOCHONDRION	0.0371124715777984	0.0315883370452393	318	Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YKR045C_p	YKR045C	hom			0.0370741879718566	0.0319945898540939	319	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YOR374W	ALD4	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.0369782679376586	0.0321836373272585	320	Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed	NADPH regeneration|ethanol metabolic process|pyruvate metabolic process|acetate biosynthetic process	aldehyde dehydrogenase [NAD(P)+] activity|aldehyde dehydrogenase (NAD) activity	mitochondrial nucleoid|mitochondrion
YHL035C	VMR1	hom	FT	NUCLEOTIDE METABOLISM|MITOCHONDRION	0.0369522326873751	0.0323052496143807	321	Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions	transport|response to drug|response to metal ion|drug transport	ATPase activity, coupled to transmembrane movement of substances	fungal-type vacuole membrane|mitochondrion|integral to membrane|ribosome
YHR199C	AIM46	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0369445281348061	0.0323413134429972	322	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YNR004W_p	SWM2	hom	FT	NUCLEUS	0.03694293817427	0.0323487600945391	323	Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds	biological_process	molecular_function	nucleolus
YMR018W_p	YMR018W	hom	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	0.0369080171280609	0.032512685058005	324	Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene	biological_process	molecular_function	cellular_component
YKL053C-A	MDM35	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|NUCLEUS|MITOCHONDRION	0.0368866264099102	0.0326134473505653	325	Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	mitochondrion organization|mitochondrial respiratory chain complex assembly	molecular_function	nucleus|cytoplasm|mitochondrial intermembrane space
YNL271C	BNI1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON	0.036866352576832	0.0327611868551221	326	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1	barbed-end actin filament capping|actin nucleation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly|establishment of mitotic spindle orientation|formin-nucleated actin cable assembly	profilin binding	incipient cellular bud site|actin filament|polarisome|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YHL033C	RPL8A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0366735946855943	0.033631618936854	327	Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YER068W	MOT2	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0366724254887649	0.0336372811786967	328	Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications	deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|protein polyubiquitination|protein ubiquitination	ubiquitin-protein ligase activity|sequence-specific DNA binding	CCR4-NOT core complex|cytoplasm
YMR230W-A_p	YMR230W-A	hom			0.036592743011305	0.034025096433004	329	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR180C	DCI1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0365793059313757	0.034090869840672	330	Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed	fatty acid beta-oxidation	dodecenoyl-CoA delta-isomerase activity	peroxisomal matrix
YBR287W_p	YBR287W	hom	FT	ENDOPLASMIC RETICULUM	0.036534079088245	0.0343130502719609	331	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YGR058W	PEF1	hom	FT	CELL CYCLE|CELL DIVISION|NUCLEUS|SITE OF POLARIZED GROWTH	0.0364961425384909	0.0345003692618618	332	Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly	bipolar cellular bud site selection|regulation of COPII vesicle coating|axial cellular bud site selection	zinc ion binding|calcium ion binding	cytosol|site of polarized growth|nucleus|cellular bud neck|cytoplasm
YGL035C	MIG1	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|ENDOMEMBRANE SYSTEM|NUCLEUS	0.0364557356881432	0.0347008455105246	333	Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion	negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus|nuclear envelope lumen|cytoplasm
YCR048W	ARE1	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0364535270179323	0.0348200974284657	334	Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication	sterol metabolic process	ergosterol O-acyltransferase activity|lanosterol O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YOR218C_d	YOR218C	het			0.0362996512380896	0.0354846162677683	335	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W	Unknown	Unknown	Unknown
YDL075W	RPL31A	hom	FT	TRANSLATION|RIBOSOME	0.0362470226220624	0.0357522695831578	336	Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication	cytoplasmic translation|regulation of translational fidelity	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR041W	RSM10	het	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.03623441972973	0.0358166189283782	337	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YPL109C_p	YPL109C	hom	FT	MITOCHONDRION	0.0362095944352029	0.0359436636902798	338	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YKL051W	SFK1	hom	FT	LIPID METABOLISM|SIGNALING|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE	0.0362067697031609	0.0359581437149167	339	Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane	vacuole organization|inositol lipid-mediated signaling|actin cytoskeleton organization	molecular_function	integral to membrane|plasma membrane
YDR047W	HEM12	het	FF|FT	COFACTOR METABOLISM|NUCLEUS	0.0362031147727692	0.0359768868460907	340	Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda	heme biosynthetic process	uroporphyrinogen decarboxylase activity	nucleus|cytoplasm
YDR213W	UPC2	hom	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|NUCLEUS	0.0361836108887779	0.0360770470539155	341	Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication	cellular response to hypoxia|positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|membrane|cytoplasm|perinuclear region of cytoplasm
YGL185C_p	YGL185C	hom	FT	OXIDATION-REDUCTION PROCESS	0.036064659674599	0.0368334973379386	342	Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	metabolic process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	cytoplasm
YEL047C	FRD1	hom	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0360566067593027	0.0367350926408251	343	Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication	cellular response to anoxia	fumarate reductase (NADH) activity	cytosol|mitochondrion|ribosome|plasma membrane
YBR123C	TFC1	het	FT	NUCLEUS	0.0360351868396237	0.0368470766611952	344	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63	transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter	RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending	transcription factor TFIIIC complex
YDR198C	RKM2	hom			0.0359914249743338	0.0370767687099393	345	Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp	peptidyl-lysine trimethylation|peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	cellular_component
YPL069C	BTS1	hom	FF|FT	PROTEIN LOCALIZATION|LIPID METABOLISM|MITOCHONDRION	0.035814725331302	0.0382468735926138	346	Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic	terpenoid biosynthetic process	farnesyltranstransferase activity	mitochondrion
YPL162C_p	YPL162C	hom			0.035695412172918	0.0386626655583691	347	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YMR011W	HXT2	hom	FT	PLASMA MEMBRANE	0.0355971086878377	0.0392019154346874	348	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose	glucose transport	pentose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YGL081W_p	YGL081W	hom			0.0355411225952326	0.0395118742269733	349	Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis	biological_process	molecular_function	cellular_component
YMR215W	GAS3	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.0353605585364169	0.0405257451568704	350	Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation	biological_process	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane|plasma membrane
YMR221C_p	YMR221C	hom	FT	MITOCHONDRION	0.0352975418086645	0.0408847365291372	351	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy	biological_process	molecular_function	mitochondrion|integral to membrane|fungal-type vacuole
YOL124C	TRM11	hom	FT	RNA PROCESSING	0.0352557306050897	0.0411244086043487	352	Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain	tRNA methylation	S-adenosylmethionine-dependent methyltransferase activity|RNA binding|tRNA (guanine-N2-)-methyltransferase activity	cytoplasm|tRNA (m2G10) methyltransferase complex
YIL005W	EPS1	hom	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0351406062278619	0.0417904855964626	353	ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family	protein retention in ER lumen|ER-associated protein catabolic process	unfolded protein binding|protein disulfide isomerase activity|chaperone binding	endoplasmic reticulum membrane
YDR531W	CAB1	het	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.0351327155095728	0.041836471416569	354	Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element	coenzyme A biosynthetic process	pantothenate kinase activity	nucleus|cytoplasm
YLL023C	POM33	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|NUCLEAR PORE	0.0351288173552358	0.0418592050193914	355	Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress	nuclear pore organization|nuclear pore complex assembly	structural constituent of nuclear pore	ribosome|integral to membrane|endoplasmic reticulum|nuclear pore
YGL069C_d	YGL069C	het			0.0350995255978406	0.0420303658442013	356	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YJR087W_d	YJR087W	hom			0.0350200771499364	0.0424975906967299	357	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2	Unknown	Unknown	Unknown
YCR066W	RAD18	hom	FF|FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0349501436047695	0.0429435211962388	358	E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA	protein monoubiquitination|error-free translesion synthesis|error-free postreplication DNA repair|error-prone translesion synthesis	ubiquitin-protein ligase activity|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding	nuclear chromatin|nucleus
YCL001W	RER1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0348374791829281	0.0435880875946294	359	Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER	protein retention in ER lumen|retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport	molecular_function	COPI-coated vesicle|integral to membrane|ER to Golgi transport vesicle
YAR015W	ADE1	hom	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.0347844408527076	0.0439407250643117	360	N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	nucleus|cytoplasm
YNL272C	SEC2	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SITE OF POLARIZED GROWTH	0.0347444854172176	0.0441524771573768	361	Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles	autophagy|exocytosis	guanyl-nucleotide exchange factor activity|phosphatidylinositol-4-phosphate binding	cytosol|transport vesicle|mating projection tip|cellular bud neck|cellular bud tip
YDR155C	CPR1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0347119445984605	0.044637528928209	362	Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress	cellular protein metabolic process|ascospore formation|positive regulation of meiosis|histone deacetylation	peptidyl-prolyl cis-trans isomerase activity|cyclosporin A binding	histone deacetylase complex|mitochondrion|Set3 complex|nucleus
YDR490C	PKH1	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	0.0346682029257763	0.0447474425428692	363	Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p	regulation of nuclear-transcribed mRNA poly(A) tail shortening|endocytosis|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly	protein kinase activity	cytosol|cell cortex|eisosome
YBR021W	FUR4	hom	FF|FT	PLASMA MEMBRANE	0.0346535054505368	0.0448701222256601	364	Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation	uracil transport|transmembrane transport	uracil:cation symporter activity	integral to membrane|membrane raft|plasma membrane
YKL208W	CBT1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION	0.0346111430485723	0.0452289672966753	365	Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p	cytochrome complex assembly|mRNA processing|mRNA stabilization	molecular_function	mitochondrion
YJR088C	EMC2	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0345154576210235	0.0455688155741046	366	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YER060W-A	FCY22	hom			0.0344871571817169	0.0460057059308151	367	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function	transmembrane transport	nucleobase transmembrane transporter activity	integral to membrane
YKR018C	YKR018C	hom	FT	NUCLEUS|MITOCHONDRION	0.0344650715044438	0.0458854934865577	368	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YDR400W	URH1	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.034434975876548	0.0460755276531094	369	Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways	pyrimidine-containing compound salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|pyrimidine nucleoside catabolic process|nicotinate nucleotide salvage	ribosylpyrimidine nucleosidase activity|nicotinic acid riboside hydrolase activity|nicotinamide riboside hydrolase activity|uridine nucleosidase activity	nucleus|cytoplasm
YDR539W	FDC1	hom	FT	KETONE METABOLISM|COFACTOR METABOLISM|PLASMA MEMBRANE	0.0343927039071564	0.0463435658996024	370	Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm	cinnamic acid catabolic process	molecular_function	cytoplasm
YER085C_p	YER085C	hom			0.0343893508418013	0.0463974796131559	371	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR275W	BSC2	hom			0.0342033819510571	0.0475601710554124	372	Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication	biological_process	molecular_function	lipid particle
YPR103W	PRE2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.034112151290415	0.0481559461706471	373	Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome	proteasomal ubiquitin-dependent protein catabolic process|proteasome core complex assembly|proteasomal ubiquitin-independent protein catabolic process	endopeptidase activity	nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YDR507C	GIN4	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH	0.034060877567477	0.0484935278365267	374	Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication	protein autophosphorylation|budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly	protein kinase activity	cellular bud neck
YLR055C	SPT8	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0340571966357903	0.0485178390032202	375	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters	histone acetylation|negative regulation of transcription from RNA polymerase II promoter|chromatin modification|positive regulation of transcription from RNA polymerase II promoter	TBP-class protein binding|transcription cofactor activity	nucleus|SAGA complex
YJL211C_d	YJL211C	hom			0.034039597269289	0.0488361092405155	376	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2	Unknown	Unknown	Unknown
YKL085W	MDH1	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0339986319814233	0.0490747811271805	377	Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated	chronological cell aging|replicative cell aging|tricarboxylic acid cycle|aerobic respiration	L-malate dehydrogenase activity|mRNA binding	mitochondrion|mitochondrial matrix
YBR270C_p	BIT2	hom			0.0339804935712454	0.0490267662529864	378	Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YIL063C	YRB2	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0339728110795504	0.0490779856790592	379	Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential	protein export from nucleus|regulation of chromatin silencing at telomere|ribosomal small subunit export from nucleus	molecular_function	integral to membrane|nucleus|nuclear pore
YKL204W	EAP1	hom	FT	TRANSLATION	0.0339321526185081	0.049349804978891	380	eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade	negative regulation of translation	eukaryotic initiation factor 4E binding	mRNA cap binding complex|cytoplasmic stress granule
YJR062C	NTA1	hom	FT	PROTEOLYSIS|MITOCHONDRION	0.0338888267884585	0.0496408451353104	381	Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation	cellular protein modification process|protein catabolic process	protein-N-terminal asparagine amidohydrolase activity	mitochondrion
YDR243C	PRP28	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0338800930759244	0.0498360085180711	382	RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site	cis assembly of pre-catalytic spliceosome	ATP-dependent RNA helicase activity	spliceosomal complex|U5 snRNP
YFR015C	GSY1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0338344103877441	0.0501452685943683	383	Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	glycogen biosynthetic process	glycogen (starch) synthase activity	mitochondrion|cytoplasm
YGL191W	COX13	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0337644958837402	0.0505184101137089	384	Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes	mitochondrial respiratory chain supercomplex assembly|aerobic respiration	enzyme regulator activity|cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YHR162W	MPC2	hom			0.0337454872975129	0.0507173630319759	385	Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|integral to mitochondrial inner membrane
YGL231C	EMC4	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0336788812998071	0.0510716048836337	386	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YKL089W	MIF2	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE	0.0336258461345778	0.0514384464941477	387	Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3	chromosome segregation|mitotic spindle organization in nucleus	centromeric DNA binding	condensed nuclear chromosome, centromeric region|condensed nuclear chromosome inner kinetochore
YDR526C_d	YDR526C	het	FF		0.033590367841397	0.0517897846014277	388	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR391C_p	YDR391C	hom	FT	NUCLEUS	0.0335642070690903	0.0519025217610198	389	Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YDL019C	OSH2	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0334809090041893	0.0524522295312322	390	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	endocytosis|maintenance of cell polarity|sterol transport|exocytosis	lipid binding|oxysterol binding|sterol transporter activity|1-phosphatidylinositol binding	endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum|cellular bud neck
YGR065C	VHT1	het	FT	PLASMA MEMBRANE	0.0334568009371804	0.0527636762568555	391	High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin	biotin transport	biotin transporter activity	integral to membrane|plasma membrane
YOR086C	TCB1	hom	FT	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE	0.0332995535540951	0.0537442113671024	392	Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact	biological_process	lipid binding	mitochondrion|plasma membrane|cortical endoplasmic reticulum
YGL091C	NBP35	het	FT	RNA PROCESSING|COFACTOR METABOLISM|NUCLEUS	0.0332652281538907	0.0539917114760534	393	Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases	iron-sulfur cluster assembly|tRNA wobble uridine modification	4 iron, 4 sulfur cluster binding|ATPase activity|iron ion binding	mitochondrion|nucleus|cytoplasm
YOR121C_d	YOR121C	hom			0.0332652099740931	0.0541712118462441	394	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W	Unknown	Unknown	Unknown
YKL017C	HCS1	hom	FT	NUCLEUS|CHROMOSOME	0.0332093006722139	0.0543970078589156	395	Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities	lagging strand elongation	ATP-dependent 5'-3' DNA helicase activity	DNA helicase A complex|alpha DNA polymerase:primase complex
YJR023C_d	YJR023C	het			0.033089725226971	0.0552720646561248	396	Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing	Unknown	Unknown	Unknown
YPL209C	IPL1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.033085793665019	0.0553010339292355	397	Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest	spindle checkpoint|attachment of spindle microtubules to kinetochore|chromosome segregation|mitotic spindle disassembly|protein phosphorylation|meiotic sister chromatid segregation|homologous chromosome segregation|regulation of cytokinesis|mitotic cell cycle G2/M transition decatenation checkpoint	protein kinase activity	spindle microtubule|spindle midzone|chromosome passenger complex|condensed nuclear chromosome kinetochore|kinetochore microtubule|spindle
YIL010W	DOT5	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|CHROMOSOME	0.0330670336345415	0.0554394393418384	398	Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth	cellular response to oxidative stress|cell redox homeostasis	thioredoxin peroxidase activity	nucleus
YGR121C	MEP1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0330058095006748	0.0558931399268925	399	Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation	nitrogen utilization|ammonium transport	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YGR280C	PXR1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.032955423198849	0.0562688418958182	400	Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain	box C/D snoRNA 3'-end processing|negative regulation of telomere maintenance via telomerase	telomerase inhibitor activity	nucleoplasm|nucleolus
YPL191C_p	YPL191C	hom			0.0329447502147055	0.0563486934102135	401	Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YOL144W	NOP8	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0328223976183719	0.0574567316177387	402	Nucleolar protein required for 60S ribosomal subunit biogenesis	ribosomal large subunit biogenesis	molecular_function	nucleolus
YIR026C	YVH1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|CELL WALL ORG/BIOGENESIS|NUCLEUS	0.0328058114753284	0.0573968152020481	403	Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases	meiosis|ascospore wall assembly|ribosomal large subunit assembly|cAMP-mediated signaling|protein dephosphorylation	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	nucleus|preribosome, large subunit precursor|cytoplasm
YNL225C	CNM67	hom	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	0.0328005002778796	0.0574743915421318	404	Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication	microtubule nucleation|mitotic spindle organization	structural constituent of cytoskeleton	outer plaque of spindle pole body|spindle pole body
YLR181C	VTA1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT	0.0327898750162504	0.0575180655125331	405	Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain	late endosome to vacuole transport via multivesicular body sorting pathway|positive regulation of protein oligomerization|late endosome to vacuole transport	ATPase activator activity	endosome|endosome membrane|multivesicular body
YJL046W	AIM22	hom	FT	MITOCHONDRION	0.0327527197086311	0.057801583336404	406	Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss	protein lipoylation	lipoate-protein ligase activity	mitochondrion
YHR112C	YHR112C	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0326986606345525	0.0582161600953146	407	Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway	sulfur compound metabolic process	cystathionine beta-lyase activity	nucleus|cytoplasm
YGR169C	PUS6	hom	FT	RNA PROCESSING|MITOCHONDRION	0.0325698028845093	0.059214330575705	408	tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|cytoplasm
YLL028W	TPO1	hom	FT	PLASMA MEMBRANE	0.0325166837169113	0.0596299199893287	409	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane	spermidine transport|putrescine transport|spermine transport	spermidine transmembrane transporter activity|spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|cellular bud membrane|plasma membrane
YGL062W	PYC1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.0324468420066765	0.0603714880685369	410	Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication	NADPH regeneration|gluconeogenesis	pyruvate carboxylase activity	cytosol
YDR124W_p	YDR124W	hom			0.0323766128348108	0.0609685048096298	411	Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor	biological_process	molecular_function	cellular_component
YBR073W	RDH54	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS	0.0323424477888294	0.0610101036943181	412	DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p	DNA geometric change|heteroduplex formation|meiotic sister chromatid segregation|reciprocal meiotic recombination|double-strand break repair via break-induced replication	DNA-dependent ATPase activity|DNA translocase activity	nucleus
YOL113W	SKM1	hom	FT	CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS|PLASMA MEMBRANE	0.0323288916833759	0.0611571809705274	413	Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth	negative regulation of gene expression|cytokinetic cell separation|protein phosphorylation|sterol import	protein serine/threonine kinase activity|protein kinase activity	plasma membrane|nucleus
YPL247C_p	YPL247C	hom	FT	NUCLEUS	0.0323202350324216	0.0612265652321682	414	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest	biological_process	molecular_function	nucleus|cytoplasm
YDR419W	RAD30	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0320512685342512	0.0633756188702695	415	DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV	error-prone translesion synthesis|error-free translesion synthesis	DNA-directed DNA polymerase activity	replication fork
YNL179C_d	YNL179C	hom			0.0319758483412957	0.0640005279268991	416	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YGR232W	NAS6	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS	0.0317727254220239	0.0661532868005783	417	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6	proteolysis|proteasome regulatory particle assembly	molecular_function	cytosol|nucleus|proteasome regulatory particle
YPL196W	OXR1	hom	FT	RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.0317644386358993	0.0657793615287899	418	Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes	cellular response to oxidative stress	molecular_function	mitochondrion
YGR275W	RTT102	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|RSC COMPLEX	0.0317555441886974	0.0658550848587264	419	Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress	chromosome segregation|nucleosome disassembly|chromatin remodeling|transcription elongation from RNA polymerase II promoter	molecular_function	RSC complex|SWI/SNF complex|nucleus
YNL173C	MDG1	hom	FT	SIGNALING|PLASMA MEMBRANE	0.0317434628689057	0.0659580547955861	420	Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations	pheromone-dependent signal transduction involved in conjugation with cellular fusion	molecular_function	membrane raft|plasma membrane
YML100W-A_p	YML100W-A	hom			0.0317120371183901	0.0662265199675323	421	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YDR461W	MFA1	hom	FT	SIGNALING|PLASMA MEMBRANE	0.0316977391125124	0.0667143792215122	422	Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YMR284W	YKU70	hom	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME	0.0316479604811593	0.066898724747324	423	Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair	chromatin assembly or disassembly|chromatin silencing|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette	damaged DNA binding|RNA binding	nuclear chromatin|nuclear telomeric heterochromatin|nuclear envelope|Ku70:Ku80 complex
YFR023W	PES4	hom	FT	NUCLEUS	0.0315884382124728	0.0672911490218698	424	Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDR415C_p	YDR415C	hom	FT	PROTEOLYSIS	0.0315226775605012	0.067863297074443	425	Putative aminopeptidase	biological_process	molecular_function	cellular_component
YDR139C	RUB1	hom			0.0314526043035028	0.0684773620838524	426	Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)	protein neddylation	protein tag	cytoplasm
YLR024C	UBR2	hom			0.0314226427323675	0.0687413106004314	427	Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex	protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YNL177C	MRPL22	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0313973590915434	0.0689646982061424	428	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOR001W	RRP6	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION|NUCLEUS	0.0313956730180315	0.069186949958527	429	Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay	nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U1 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear retention of pre-mRNA at the site of transcription|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription	3'-5'-exoribonuclease activity	nucleolus|nucleus|nuclear exosome (RNase complex)
YJL160C_p	YJL160C	hom			0.0313688212234794	0.0692175535865481	430	Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YNL146C-A_p	YNL146C-A	hom			0.0313233859978199	0.0696216955756515	431	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL316C	PHA2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.03131619360555	0.0696858484034229	432	Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway	L-phenylalanine biosynthetic process	prephenate dehydratase activity	cytoplasm
YGR152C	RSR1	hom	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0312581142934862	0.0702056684732673	433	GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases	bipolar cellular bud site selection|small GTPase mediated signal transduction|axial cellular bud site selection|cellular bud site selection	GTPase activity|signal transducer activity	plasma membrane|cellular bud neck
YOR102W_d	YOR102W	het			0.031198345613673	0.0707439247967105	434	Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex	Unknown	Unknown	Unknown
YHR157W	REC104	hom	FT	CELL CYCLE|NUCLEUS|CHROMOSOME	0.0311850669649557	0.0708639658860725	435	Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YBR296C	PHO89	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0311762121611816	0.0709441074634731	436	Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification	phosphate ion transport|transmembrane transport	sodium:inorganic phosphate symporter activity	integral to membrane|plasma membrane
YDR493W	MZM1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0311383837999683	0.0712873149851325	437	Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog	mitochondrial respiratory chain complex III assembly	molecular_function	mitochondrion|mitochondrial matrix
YLR284C	ECI1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0310725959210916	0.0719722566537144	438	Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced	fatty acid beta-oxidation	dodecenoyl-CoA delta-isomerase activity	peroxisome
YOL143C	RIB4	hom	FT	NUCLEUS	0.031050561286554	0.0721318203655242	439	Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin	riboflavin biosynthetic process	6,7-dimethyl-8-ribityllumazine synthase activity	nucleus|cytoplasm
YER104W	RTT105	het	FT	NUCLEUS	0.0310251779734068	0.0723225382429062	440	Protein with a role in regulation of Ty1 transposition	negative regulation of transposition, RNA-mediated	molecular_function	nucleus|cytoplasm
YJL051W	IRC8	hom			0.0310180352441216	0.0725586908400882	441	Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc	mitotic recombination	molecular_function	integral to membrane|cellular bud
YGL070C	RPB9	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|NUCLEUS|RNA POL II, HOLOENZYME	0.0310134182938674	0.0728149657345289	442	RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription	transcription initiation from RNA polymerase II promoter|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|response to DNA damage stimulus|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity	DNA-directed RNA polymerase II, core complex
YCR013C_d	YCR013C	het			0.0310061160319356	0.0724980566909025	443	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant	Unknown	Unknown	Unknown
YJL015C_d	YJL015C	het			0.0309896004770834	0.0727784493428301	444	Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W	Unknown	Unknown	Unknown
YGL203C	KEX1	hom	FT	PROTEOLYSIS|GOLGI APPARATUS	0.0309626919815969	0.0728991980825281	445	Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins	protein processing	serine-type carboxypeptidase activity	trans-Golgi network
YOR043W	WHI2	hom	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	0.030959577530824	0.0729280383015796	446	Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression	response to salt stress|mitochondrion degradation|actin filament organization|endocytosis|response to heat|regulation of growth|response to stress	phosphatase activator activity	cellular_component
YIL162W	SUC2	hom	FT	CARBOHYDRATE METABOLISM|MITOCHONDRION	0.0309478936195746	0.0730363160272491	447	Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively	sucrose catabolic process	beta-fructofuranosidase activity	mitochondrion|extracellular region|cytoplasm
YDR056C_p	YDR056C	hom	FT	ENDOPLASMIC RETICULUM	0.0309259945280332	0.0732396145314435	448	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein	biological_process	molecular_function	endoplasmic reticulum
YPR117W_p	YPR117W	hom			0.0307161892246824	0.0753414230544199	449	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YCR035C	RRP43	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0307091814328153	0.0752774537181084	450	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress	nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing	molecular_function	nucleoplasm|nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|cytoplasm
YJR076C	CDC11	het	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0307048207151579	0.0754931733778746	451	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells	maintenance of cell polarity|cell cycle cytokinesis|positive regulation of protein kinase activity	structural molecule activity|GTP binding|1-phosphatidylinositol binding	spindle microtubule|septin complex|prospore membrane|ascospore wall|mating projection base|meiotic spindle|cellular bud neck septin ring|septin filament array|cytoplasmic microtubule|mating projection tip
YIL072W	HOP1	hom	FT	CELL CYCLE|NUCLEUS|CHROMOSOME	0.030672191804868	0.0756296989495016	452	Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments	synaptonemal complex assembly|meiotic recombination checkpoint|synapsis	four-way junction DNA binding	condensed nuclear chromosome|lateral element
YLR147C	SMD3	het	FT	RNA PROCESSING|NUCLEUS	0.0306548676875185	0.0760576119076281	453	Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3	mRNA splicing, via spliceosome	mRNA binding	commitment complex|U1 snRNP|U2-type prespliceosome|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YLR348C	DIC1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.0306512511370922	0.0760922518440788	454	Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix	dicarboxylic acid transport	dicarboxylic acid transmembrane transporter activity	mitochondrial envelope|mitochondrion|integral to membrane
YPL167C	REV3	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0305834584607408	0.0764801731657749	455	Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair	error-prone translesion synthesis|error-free translesion synthesis	DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YGR028W	MSP1	hom	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0305461596724864	0.0768399867805706	456	Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase	protein targeting to mitochondrion	ATPase activity	mitochondrial outer membrane|mitochondrion
YHR094C	HXT1	hom	FT	PLASMA MEMBRANE	0.0305252328031104	0.0770424671729428	457	Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication	mannose transport|glucose transport	galactose transmembrane transporter activity|pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YMR288W	HSH155	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0304588521918146	0.0778649023401524	458	U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155	spliceosomal complex assembly|mRNA splicing, via spliceosome	mRNA binding	U2 snRNP|U2-type prespliceosome
YLR032W	RAD5	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0304336875829355	0.0779333390731232	459	DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress	double-strand break repair|postreplication repair|protein polyubiquitination|free ubiquitin chain polymerization	four-way junction helicase activity|four-way junction DNA binding|DNA-dependent ATPase activity|Y-form DNA binding	nuclear chromatin
YNL071W	LAT1	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0303915619187486	0.0783460923468	460	Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA	acetyl-CoA biosynthetic process from pyruvate	dihydrolipoyllysine-residue acetyltransferase activity	mitochondrion|mitochondrial pyruvate dehydrogenase complex
YLL063C	AYT1	hom			0.0303493122408784	0.0787618453418193	461	Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis	secondary metabolic process	trichothecene 3-O-acetyltransferase activity	cellular_component
YCR093W	CDC39	het	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|NUCLEUS	0.0303467120627792	0.0792349664104812	462	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor	response to pheromone involved in conjugation with cellular fusion|regulation of cell cycle|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter	molecular_function	CCR4-NOT core complex|nucleus|cytoplasm
YOL077C	BRX1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0303017868963549	0.0792316553257716	463	Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif	ribosomal large subunit assembly	5S rRNA binding|rRNA primary transcript binding	nucleolus|preribosome, large subunit precursor
YGR175C	ERG1	het	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0302718501760037	0.0795287612673184	464	Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine	ergosterol biosynthetic process	drug binding|squalene monooxygenase activity	endoplasmic reticulum|lipid particle
YLR208W	SEC13	het	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|NUCLEAR PORE	0.0301997140104252	0.0802483942846557	465	Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress	positive regulation of transcription, DNA-dependent|ER-associated protein catabolic process|positive regulation of GTPase activity|nuclear pore distribution|COPII-coated vesicle budding	structural molecule activity	COPII vesicle coat|nuclear pore outer ring|Seh1-associated complex
YJL080C	SCP160	hom	FT	CELL CYCLE|SIGNALING|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0301876985392262	0.0804138870207317	466	Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins	meiotic telomere clustering|pheromone-dependent signal transduction involved in conjugation with cellular fusion|chromosome segregation|intracellular mRNA localization|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	G-protein alpha-subunit binding|RNA binding	endoplasmic reticulum membrane|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YNL275W	BOR1	hom	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT|PLASMA MEMBRANE	0.0301757346567247	0.0804887810067502	467	Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1	borate transport|protein targeting to vacuole	borate efflux transmembrane transporter activity	integral to membrane|plasma membrane|fungal-type vacuole
YEL055C	POL5	het	FT	NUCLEUS	0.0301733619052268	0.0805125989700844	468	DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA	rRNA transcription|DNA replication	DNA-directed DNA polymerase activity	nucleolus
YJL203W	PRP21	het	FT	RNA PROCESSING|NUCLEUS	0.0301031201572771	0.0812202899161333	469	Subunit of the SF3a splicing factor complex, required for spliceosome assembly	mRNA splicing, via spliceosome	RNA binding	U2 snRNP|U2-type prespliceosome
YEL013W	VAC8	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.0300759684665378	0.0814951941397037	470	Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions	piecemeal microautophagy of nucleus|vacuole inheritance|CVT vesicle assembly|vacuole fusion, non-autophagic|macroautophagy|nucleus-vacuole junction assembly	protein anchor	fungal-type vacuole membrane|nucleus-vacuole junction|Myo2p-Vac17p-Vac8p transport complex
YOR099W	KTR1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0300672961667508	0.0815831579048836	471	Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress	N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YNL086W_p	SNN1	hom			0.0300194693764254	0.0821152840034915	472	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes	biological_process	molecular_function	endosome|BLOC-1 complex
YMR290W-A_d	YMR290W-A	het	FF		0.0300032523826882	0.0822351451911195	473	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase	Unknown	Unknown	Unknown
YBR084W	MIS1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.0299986167064732	0.0822825013753023	474	Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase	nucleobase-containing compound metabolic process|folic acid biosynthetic process	formate-tetrahydrofolate ligase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methenyltetrahydrofolate cyclohydrolase activity	mitochondrion
YBR239C_p	ERT1	hom	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM|NUCLEUS	0.0299615599886538	0.0827993632080019	475	Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition	biological_process	sequence-specific DNA binding	nucleus|cytoplasm
YKR079C	TRZ1	het	FT	RNA PROCESSING|NUCLEUS|MITOCHONDRION	0.0299561637250474	0.0829466169030864	476	tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2	tRNA 3'-trailer cleavage, endonucleolytic	3'-tRNA processing endoribonuclease activity	mitochondrion|nucleus|cytoplasm
YDR062W	LCB2	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0299082324628443	0.0832102546596444	477	Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine	sphingolipid biosynthetic process	serine C-palmitoyltransferase activity	SPOTS complex|serine C-palmitoyltransferase complex
YKR010C	TOF2	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|MITOCHONDRION	0.0298667678947826	0.0836386948106787	478	Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication	nucleolus organization|rDNA condensation|chromatin silencing at rDNA|protein localization to nucleolar rDNA repeats	phosphatase activator activity	mitochondrion|nucleolus
YOR006C	TSR3	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.029862647847558	0.0836813632915718	479	Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress	maturation of SSU-rRNA	molecular_function	nucleus|cytoplasm
YGR237C_p	YGR237C	hom			0.0298208931781712	0.0842999159405207	480	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YOR078W	BUD21	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0297918172607509	0.0844176655354969	481	Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|90S preribosome
YPR149W	NCE102	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE	0.0297534446254341	0.0848187420966384	482	Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)	eisosome assembly|protein secretion|negative regulation of protein phosphorylation|plasma membrane organization|establishment of protein localization to plasma membrane	molecular_function	mitochondrion|integral to membrane|membrane raft|endoplasmic reticulum|cellular bud membrane|plasma membrane|mating projection membrane|cytoplasm
YBR269C_p	FMP21	hom	FT	MITOCHONDRION	0.0297417977493825	0.0849407813155664	483	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YJL061W	NUP82	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0296949296693546	0.0854333137939466	484	Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p)	mRNA export from nucleus|protein export from nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|ribosomal small subunit export from nucleus	structural constituent of nuclear pore	integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore linkers|nuclear pore
YDR421W	ARO80	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0296071608529016	0.0863618743781725	485	Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids	aromatic amino acid family catabolic process|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|nucleic acid binding transcription factor activity	nucleus
YOL054W	PSH1	hom	FT	PROTEOLYSIS|NUCLEUS|CHROMOSOME	0.0294710028856819	0.0878184810131342	486	E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	chromosome, centromeric region|nucleus
YFL051C_p	YFL051C	hom	FT	PLASMA MEMBRANE	0.0294227099367486	0.0883398487566815	487	Putative protein of unknown function; YFL051C is not an essential gene	biological_process	molecular_function	cellular_component
YDL113C	ATG20	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.0294059258149508	0.0885216321048369	488	Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate	mitochondrion degradation|early endosome to Golgi transport|macroautophagy|CVT pathway	phosphatidylinositol-3-phosphate binding	endosome|pre-autophagosomal structure|extrinsic to membrane
YHR015W	MIP6	hom	FT	RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0293702371807226	0.0889091657660962	489	Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication	mRNA export from nucleus	RNA binding	nuclear pore
YJR060W	CBF1	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CHROMOSOME|KINETOCHORE	0.0293132100401382	0.0895312436295668	490	Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress	regulation of transcription from RNA polymerase II promoter in response to methionine|negative regulation of transcription from RNA polymerase II promoter|methionine biosynthetic process|chromosome segregation|Unknown|chromatin remodeling|negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II repressing transcription factor binding|centromeric DNA binding	chromosome, centromeric region|mitochondrion|nucleus|kinetochore
YPR025C	CCL1	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|NUCLEUS|MITOCHONDRION|RNA POL II, HOLOENZYME	0.0292090682742261	0.0906763063849668	491	Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters	phosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity|cyclin-dependent protein kinase regulator activity	mitochondrion|holo TFIIH complex|TFIIK complex
YGR181W	TIM13	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0291924242051483	0.0908603983203739	492	Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane	protein import into mitochondrial inner membrane	protein transporter activity	mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex|mitochondrial intermembrane space
YNL183C	NPR1	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|GOLGI APPARATUS|PLASMA MEMBRANE	0.0291387005387339	0.0914566604129277	493	Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex	regulation of transmembrane transporter activity|regulation of nitrogen utilization|protein phosphorylation|negative regulation of endocytosis	protein serine/threonine kinase activity	Golgi apparatus|plasma membrane|cytoplasm
YBR041W	FAT1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.0291386602992788	0.0914571081933676	494	Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids	very long-chain fatty acid metabolic process|long-chain fatty acid transport	very long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity	intrinsic to internal side of plasma membrane|integral to membrane|endoplasmic reticulum|lipid particle|peroxisome
YHR184W	SSP1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION	0.0290963296350158	0.0919776043589346	495	Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis	ascospore wall assembly|protein complex assembly	molecular_function	prospore membrane
YGL122C	NAB2	het	FT	RNA PROCESSING|RNA LOCALIZATION|NUCLEUS	0.0289779660604407	0.093259393197339	496	Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress	poly(A)+ mRNA export from nucleus|mRNA polyadenylation|regulation of mRNA stability	poly(A) RNA binding	nucleus|cytoplasm
YLR191W	PEX13	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION	0.0289484286211086	0.0935937526449251	497	Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p	protein import into peroxisome matrix, docking	protein binding, bridging	peroxisomal membrane
YMR101C	SRT1	hom	FT	CARBOHYDRATE METABOLISM	0.0289422347995428	0.0939580492327916	498	Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase	protein glycosylation	dehydrodolichyl diphosphate synthase activity|prenyltransferase activity	lipid particle
YPL123C	RNY1	hom			0.0288831010239696	0.0943857869875406	499	Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity	cell morphogenesis|RNA catabolic process|apoptotic process	endoribonuclease activity	cytosol|extracellular region|vacuole
YMR158W	MRPS8	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0288822600428428	0.0943462597550914	500	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YOR170W_d	YOR170W	hom			0.0287678518351749	0.0956588063415835	501	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4	Unknown	Unknown	Unknown
YNL133C	FYV6	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0287221603350264	0.096187067834785	502	Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining	double-strand break repair via nonhomologous end joining	molecular_function	nucleus
YDR487C	RIB3	het	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0287062161174779	0.0963719548961645	503	3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration	riboflavin biosynthetic process|aerobic respiration	3,4-dihydroxy-2-butanone-4-phosphate synthase activity	cytosol|mitochondrial intermembrane space
YNL251C	NRD1	het	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.0286492689141517	0.09703462865995	504	RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3&#8242; end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5, to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites	mRNA 3'-end processing|nuclear mRNA surveillance|termination of RNA polymerase II transcription, exosome-dependent|antisense RNA transcript catabolic process|tRNA 3'-end processing|snRNA 3'-end processing|snoRNA 3'-end processing|CUT catabolic process	RNA binding|transcription regulatory region RNA binding|protein domain specific binding	Nrd1 complex|nucleus
YIL071C	PCI8	hom	FT	NUCLEUS	0.0286479973676298	0.0970494666446111	505	Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain	cullin deneddylation	molecular_function	signalosome
YBL056W	PTC3	hom	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0286093339598308	0.0975015058436277	506	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication	inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YPR113W	PIS1	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS	0.0285579358017811	0.0982554657227398	507	Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins	phosphatidylinositol biosynthetic process	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity	mitochondrial outer membrane|mitochondrion|integral to membrane|Golgi apparatus
YBR228W	SLX1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0285210427290743	0.0986908482959908	508	Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p	DNA-dependent DNA replication	5'-flap endonuclease activity	Slx1-Slx4 complex|nucleus
YGR254W	ENO1	hom	FT	MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.028476089703377	0.0992234273265418	509	Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress	regulation of vacuole fusion, non-autophagic|gluconeogenesis|glycolysis	phosphopyruvate hydratase activity	mitochondrion|phosphopyruvate hydratase complex|plasma membrane|fungal-type vacuole|cytoplasm
YDR058C	TGL2	hom	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0284408565453056	0.0994909539833368	510	Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli	triglyceride catabolic process	triglyceride lipase activity	mitochondrion
YDL221W_d	YDL221W	het			0.0284367203792587	0.0995906832274303	511	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13	Unknown	Unknown	Unknown
YGR146C	ECL1	hom			0.02843582227404	0.0995508950680801	512	Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	cellular_component
YFR039C_p	YFR039C	hom			0.0283815602055392	0.100198801657119	513	Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces	biological_process	molecular_function	cellular_component
YMR109W	MYO5	hom	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0282684014010607	0.101560763783388	514	One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization	bipolar cellular bud site selection|endocytosis|exocytosis|fungal-type cell wall organization|response to salt stress|receptor-mediated endocytosis|actin cortical patch localization|response to osmotic stress	microfilament motor activity	mating projection tip|actin cortical patch
YDR021W	FAL1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0282096166440193	0.102274081284801	515	Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus|FAl1-SGD1 complex
YDR135C	YCF1	hom	FT	NUCLEOTIDE METABOLISM	0.0281919602135715	0.102489107862145	516	Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR	bilirubin transport|response to metal ion|transmembrane transport	bilirubin transmembrane transporter activity|glutathione S-conjugate-exporting ATPase activity	fungal-type vacuole membrane|integral to membrane
YFL055W	AGP3	hom	FT	PLASMA MEMBRANE	0.0281610817245281	0.103071469805264	517	Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YOR275C	RIM20	hom	FT	ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS|NUCLEUS	0.0281407506743547	0.103114790620523	518	Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation	proteolysis|response to pH|protein processing|invasive growth in response to glucose limitation|sporulation resulting in formation of a cellular spore	molecular_function	nucleus|cytoplasm
YDR511W	ACN9	hom	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|MITOCHONDRION	0.0281367254504382	0.103421348519942	519	Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes	carbon utilization|regulation of gluconeogenesis	molecular_function	mitochondrion|mitochondrial intermembrane space
YFL038C	YPT1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS	0.0279740654644926	0.105172409691337	520	Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)	Golgi vesicle budding|Golgi vesicle docking|early endosome to Golgi transport|macroautophagy|endocytic recycling|protein complex assembly|CVT pathway|retrograde vesicle-mediated transport, Golgi to ER|SNARE complex disassembly|ER to Golgi vesicle-mediated transport|COPII-coated vesicle budding	SNARE binding|GTPase activity	trans-Golgi network|mitochondrion|Golgi stack|endoplasmic reticulum membrane|Golgi membrane|pre-autophagosomal structure
YBR293W	VBA2	hom			0.0279445278472359	0.105540406588581	521	Permease of basic amino acids in the vacuolar membrane	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity|drug transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YBR013C_p	YBR013C	hom			0.0278656944804504	0.106527559270724	522	Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein	biological_process	molecular_function	cellular_component
YDR443C	SSN2	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0278431582534385	0.106863377865339	523	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II transcription coactivator activity|RNA polymerase II transcription factor recruiting transcription factor activity	mediator complex
YGR019W	UGA1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0278406806315955	0.10689459394958	524	Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress	nitrogen utilization|gamma-aminobutyric acid catabolic process	4-aminobutyrate transaminase activity	intracellular
YHR161C	YAP1801	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON	0.0278366832497575	0.106892674504566	525	Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication	endocytosis	clathrin binding	actin cortical patch
YIR002C	MPH1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0278142914112991	0.10743726991815	526	3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases	negative regulation of strand invasion|recombinational repair|DNA replication, Okazaki fragment processing	flap-structured DNA binding|3'-5' DNA helicase activity	nucleus
YMR235C	RNA1	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|GENE SILENCING|NUCLEUS	0.0276836853358482	0.108834624473269	527	GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport	rRNA metabolic process|ribosomal subunit export from nucleus|tRNA metabolic process|rRNA export from nucleus|RNA import into nucleus|protein import into nucleus|chromatin silencing at telomere	Ran GTPase activator activity	cytosol|integral to membrane|nucleus
YOR057W	SGT1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|SIGNALING|UBIQUITIN LIGASE COMPLEX	0.0276637818426196	0.109089290205663	528	Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress	regulation of cell cycle|kinetochore assembly|cAMP-mediated signaling|protein complex assembly|protein ubiquitination	protein binding, bridging|chaperone binding	ubiquitin ligase complex
YMR268C	PRP24	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0276599633832338	0.109138201306954	529	Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling	assembly of spliceosomal tri-snRNP|spliceosomal complex assembly	U6 snRNA binding|snRNA binding	U6 snRNP
YNR025C_d	YNR025C	hom			0.027621629305255	0.109683131348776	530	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase	Unknown	Unknown	Unknown
YGL178W	MPT5	hom	FT	TRANSLATION	0.0275536137555893	0.110613744484529	531	mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity	negative regulation of translation|negative regulation of translational initiation|Unknown	mRNA binding|protein binding, bridging	cytoplasm
YKL132C	RMA1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.027503648072159	0.111155383296411	532	Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	tetrahydrofolylpolyglutamate synthase activity	mitochondrion
YFR045W_p	YFR045W	hom	FT	MITOCHONDRION	0.0274558983986766	0.111777403154792	533	Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white	transport	transporter activity	integral to membrane|mitochondrial inner membrane
YGL055W	OLE1	het	FF|FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0274112370863224	0.112361673080553	534	Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria	unsaturated fatty acid biosynthetic process	electron carrier activity|stearoyl-CoA 9-desaturase activity	integral to endoplasmic reticulum membrane|integral to membrane
YDR491C_d	YDR491C	hom			0.0273911131451981	0.112625724679476	535	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR481C	PHO8	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.0273630574506501	0.112994666639131	536	Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN	nicotinamide nucleotide metabolic process|protein dephosphorylation	nucleotide phosphatase activity|alkaline phosphatase activity	fungal-type vacuole membrane
YGL126W	SCS3	hom	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM	0.0273339354550106	0.113755828033924	537	Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol	phospholipid metabolic process	molecular_function	integral to membrane|endoplasmic reticulum
YBL017C	PEP1	hom	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0273278396761441	0.113459139188167	538	Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments	vacuolar transport|protein targeting to vacuole	signal sequence binding	integral to membrane|Golgi apparatus
YDR003W	RCR2	hom	FT	VESICLE-MEDIATED TRANSPORT	0.0273149957457893	0.114006490060863	539	Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication	vesicle-mediated transport	molecular_function	vesicle|integral to membrane|fungal-type vacuole|cytoplasm
YJR042W	NUP85	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0273095058551008	0.113701530596125	540	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75	positive regulation of transcription, DNA-dependent|mRNA export from nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|nuclear pore distribution	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore outer ring
YOR124C	UBP2	hom	FT	PROTEOLYSIS	0.0272711496894098	0.11420995576175	541	Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity	protein deubiquitination|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ubiquitin-specific protease activity	cytoplasm
YBR249C	ARO4	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0272431330541583	0.114582455846464	542	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress	aromatic amino acid family biosynthetic process	3-deoxy-7-phosphoheptulonate synthase activity	nucleus|cytoplasm
YBR262C	AIM5	hom	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0271982183777888	0.115181620021177	543	Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YNL163C	RIA1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM	0.027185976063241	0.115399597289479	544	Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes	mature ribosome assembly	GTPase activity	cytoplasm
YAL068C	PAU8	hom	FT	TRANSCRIPTION FROM RNA POL II	0.0271252933710486	0.116214103048317	545	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YLR396C	VPS33	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	0.0270828601053451	0.116731794280914	546	ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole	regulation of SNARE complex assembly|endocytosis|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle fusion with vacuole|Golgi to vacuole transport|vacuole organization|vacuole fusion, non-autophagic|vesicle docking|protein targeting to vacuole	phosphatidylinositol binding|ATP binding	cytosol|fungal-type vacuole membrane|HOPS complex|fungal-type vacuole|CORVET complex
YML113W	DAT1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0270779772743739	0.116797768879933	547	DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability	negative regulation of transcription from RNA polymerase II promoter	AT DNA binding	nucleus
YML100W	TSL1	hom	FT	CARBOHYDRATE METABOLISM	0.0270755269799996	0.117103984579817	548	Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication	trehalose biosynthetic process|response to stress	enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YDR051C	DET1	hom	FT	NUCLEUS	0.0270597724366779	0.117044002432173	549	Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel	intracellular sterol transport|dephosphorylation	acid phosphatase activity	nucleus|cytoplasm
YCR028C	FEN2	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PLASMA MEMBRANE	0.02705781814087	0.117070459889207	550	Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress	pantothenate transmembrane transport|endocytosis	pantothenate transmembrane transporter activity	integral to membrane|plasma membrane
YER185W	PUG1	hom	FT	PLASMA MEMBRANE	0.0270401480349122	0.117309892722776	551	Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins	heme transport	molecular_function	integral to membrane|plasma membrane
YDR510W	SMT3	het	FT	NUCLEUS|CHROMOSOME|CYTOSKELETON	0.0270252148117321	0.117512539770534	552	Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2	protein sumoylation	protein tag	condensed nuclear chromosome|nucleus|septin ring
YHR172W	SPC97	het	FT	CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	0.0270199316552453	0.117803374071305	553	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque	microtubule nucleation	structural constituent of cytoskeleton	outer plaque of spindle pole body|gamma-tubulin small complex, spindle pole body|inner plaque of spindle pole body
YDR278C_d	YDR278C	hom			0.0269943832418415	0.117931799543379	554	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL238C	GUD1	hom			0.0269648495755252	0.11833450905224	555	Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures	guanine metabolic process	guanine deaminase activity|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	cytoplasm
YOL084W	PHM7	hom	FT	PLASMA MEMBRANE	0.0269423731771097	0.118641710195137	556	Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YPL096W	PNG1	hom	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS|MITOCHONDRION	0.0269011168664807	0.119207216085734	557	Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p	misfolded or incompletely synthesized protein catabolic process|protein deglycosylation	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity	cytosol|mitochondrion|nucleus
YNR017W	TIM23	het	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0268738133168303	0.11963778348256	558	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel	protein import into mitochondrial matrix	mitochondrion targeting sequence binding|protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane presequence translocase complex
YDL060W	TSR1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0268415536640639	0.120027379050087	559	Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress	rRNA processing|ribosome biogenesis	ribonucleoprotein complex binding	nucleolus|cytoplasm|90S preribosome
YJR073C	OPI3	hom	FF|FT	LIPID METABOLISM|MITOCHONDRION	0.0268048883922099	0.120811496803436	560	Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis	phosphatidylcholine biosynthetic process	phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|phosphatidyl-N-methylethanolamine N-methyltransferase activity	mitochondrion|integral to membrane
YDL133W	SRF1	hom			0.0267914116772209	0.120721233929388	561	Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients	positive regulation of catalytic activity	molecular_function	integral to membrane
YJL143W	TIM17	het	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0267867061819487	0.120786508350994	562	Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex	protein import into mitochondrial matrix|mitochondrial genome maintenance	protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane presequence translocase complex
YDR374C_p	YDR374C	hom			0.0267727128163143	0.121425168440397	563	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJR056C	YJR056C	hom	FT	NUCLEUS	0.026752898804361	0.121256294824163	564	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YPL107W_p	YPL107W	hom	FT	MITOCHONDRION	0.026701946389388	0.121967025973131	565	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene	biological_process	molecular_function	mitochondrion
YCR102C_p	YCR102C	hom	FT	OXIDATION-REDUCTION PROCESS	0.0266730525878126	0.123042230202368	566	Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family	response to copper ion	molecular_function	cellular_component
YHR210C_p	YHR210C	hom	FT	CARBOHYDRATE METABOLISM	0.026649913462804	0.122696184305247	567	Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions	biological_process	molecular_function	cellular_component
YDL234C	GYP7	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	0.0265953524407569	0.123464421312065	568	GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking	regulation of vacuole fusion, non-autophagic|vesicle-mediated transport	Rab GTPase activator activity	cytoplasm
YLR228C	ECM22	hom	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|NUCLEUS	0.026576205715983	0.123903041532735	569	Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication	positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|membrane|perinuclear region of cytoplasm
YOR133W	EFT1	hom	FT	TRANSLATION|NUCLEOTIDE METABOLISM|RIBOSOME	0.0265513001268433	0.124087426807321	570	Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication	translational elongation	translation elongation factor activity	ribosome
YER048C	CAJ1	hom	FT	NUCLEUS	0.0265024149320661	0.124781647960144	571	Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly	protein folding	chaperone binding	nucleus
YGL225W	VRG4	het	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS	0.0264714536262039	0.125391939750892	572	Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi	GDP-mannose transport	GDP-mannose transmembrane transporter activity	mitochondrion|integral to membrane|Golgi apparatus
YNL043C_d	YNL043C	hom			0.0264510667859133	0.125514101608716	573	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W	Unknown	Unknown	Unknown
YIL113W	SDP1	hom	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0264479834378428	0.125558190269425	574	Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock	inactivation of MAPK activity involved in cell wall biogenesis|MAPK cascade involved in cell wall biogenesis	MAP kinase tyrosine phosphatase activity	nucleus|cytoplasm
YOL078W	AVO1	het	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE	0.0264428407070136	0.125631752792264	575	Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth	TOR signaling cascade|fungal-type cell wall organization|regulation of cell growth|negative regulation of Ras protein signal transduction|establishment or maintenance of actin cytoskeleton polarity	phosphatidylinositol-4,5-bisphosphate binding|Ras GTPase binding	TORC2 complex|plasma membrane|cytoplasm
YML128C	MSC1	hom	FT	CELL CYCLE|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0264214494746339	0.125938096979201	576	Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated	reciprocal meiotic recombination	molecular_function	mitochondrion|endoplasmic reticulum|plasma membrane
YER067W	RGI1	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS|PLASMA MEMBRANE	0.0263841212570142	0.126474067684898	577	Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress	energy reserve metabolic process	molecular_function	cell periphery|nucleus|cytoplasm
YCR049C_d	YCR049C	hom			0.026353496154549	0.126915117159044	578	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCL009C	ILV6	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0263332397127113	0.12720749850912	579	Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria	branched-chain amino acid biosynthetic process	enzyme regulator activity|acetolactate synthase activity	mitochondrial nucleoid|acetolactate synthase complex|mitochondrion
YHR006W	STP2	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|PLASMA MEMBRANE	0.0263267460259873	0.127301339149289	580	Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YHR064C	SSZ1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	0.0263140132687081	0.127485497222302	581	Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP	cytoplasmic translation|regulation of translational fidelity|rRNA processing	unfolded protein binding	polysome|cytoplasm
YBL087C	RPL23A	hom	FT	TRANSLATION|RIBOSOME	0.0262989262511432	0.129420707794518	582	Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGL120C	PRP43	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION	0.0262622793307943	0.128235873666521	583	RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|spliceosomal complex disassembly|ribosomal large subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA|rRNA processing	ATP-dependent RNA helicase activity	mitochondrion|post-mRNA release spliceosomal complex|90S preribosome
YHR063C	PAN5	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	0.0261824984403423	0.129399779615284	584	2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE	pantothenate biosynthetic process	2-dehydropantoate 2-reductase activity	cytoplasm
YHL042W_p	YHL042W	hom			0.0261460358189917	0.129934447702134	585	Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	cellular_component
YDR397C	NCB2	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0261204340620261	0.130310881125897	586	Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity|transcription corepressor activity	nucleus|negative cofactor 2 complex
YGL249W	ZIP2	hom	FT	CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0260996696141407	0.130789034659168	587	Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	synaptonemal complex assembly|synapsis|reciprocal meiotic recombination	molecular_function	synaptonemal complex
YNL075W	IMP4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0260973662439565	0.130650780917596	588	Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs	rRNA processing	snoRNA binding|single-stranded telomeric DNA binding|rRNA primary transcript binding	small-subunit processome|Mpp10 complex|90S preribosome
YLR165C	PUS5	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION	0.0260859663589454	0.130819009613151	589	Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability	rRNA modification|pseudouridine synthesis	pseudouridylate synthase activity	mitochondrion
YML010W	SPT5	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0260666007328252	0.131105174061716	590	Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair	7-methylguanosine mRNA capping|intracellular mRNA localization|mRNA splicing, via spliceosome|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair	core RNA polymerase I binding transcription factor activity|core RNA polymerase II binding transcription factor activity|rRNA binding|RNA polymerase II core binding|RNA polymerase I transcription factor binding|RNA polymerase I core binding	DSIF complex|mitochondrion|rDNA heterochromatin|nucleus
YDR031W	MIC14	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS|MITOCHONDRION	0.0260591061543616	0.131216051032619	591	Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	aerobic respiration	molecular_function	nucleus|mitochondrial intermembrane space|cytoplasm
YGR217W	CCH1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0260240196240457	0.131736098112642	592	Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together	calcium ion transport	voltage-gated calcium channel activity|calcium channel activity	integral to membrane|plasma membrane
YKR055W	RHO4	hom	FT	SIGNALING|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0260043805344234	0.13202788180204	593	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity	positive regulation of formin-nucleated actin cable assembly|maintenance of cell polarity|regulation of formin-nucleated actin cable assembly	GTPase activity	incipient cellular bud site|plasma membrane|cellular bud neck
YLR184W_d	YLR184W	hom			0.0259741977197954	0.132477292087343	594	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER064C	VHR2	hom	FT	NUCLEUS	0.0259569401399455	0.132734782309892	595	Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	regulation of transcription, DNA-dependent	molecular_function	nucleus
YGL134W	PCL10	hom	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0259477853903958	0.132871532109458	596	Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate	negative regulation of glycogen biosynthetic process|regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YMR173W	DDR48	hom	FT	RESPONSE TO DNA DAMAGE	0.0259365783272149	0.133039086910142	597	DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress	DNA repair	ATPase activity|GTPase activity	cytoplasm
YNL146W_p	YNL146W	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0258876206309485	0.133772962396668	598	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YBR167C	POP7	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0258859772274324	0.133797651197213	599	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YHR193C	EGD2	hom	FT	PROTEIN LOCALIZATION|NUCLEUS	0.0258815386449455	0.133922342486211	600	Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes	'de novo' cotranslational protein folding	unfolded protein binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding	nascent polypeptide-associated complex
YGL223C	COG1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0258713279214464	0.134424623954726	601	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YDR252W	BTT1	hom	FT	PROTEIN LOCALIZATION|NUCLEUS	0.0258591340504607	0.134201414380919	602	Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3	'de novo' cotranslational protein folding	unfolded protein binding	nascent polypeptide-associated complex|CCR4-NOT complex
YKR049C	FMP46	hom	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0258405653278696	0.134539374901494	603	Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	oxidoreductase activity	mitochondrion
YBR221C	PDB1	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0258330268415265	0.134595010279634	604	E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria	acetyl-CoA biosynthetic process from pyruvate	pyruvate dehydrogenase (acetyl-transferring) activity	mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YER093C-A	AIM11	hom			0.0258265457275674	0.134692858520561	605	Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YER175W-A_p	YER175W-A	hom			0.0258228964743879	0.134747977088608	606	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YGR185C	TYS1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEUS	0.0257808508779449	0.135559199451069	607	Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress	tyrosyl-tRNA aminoacylation	tyrosine-tRNA ligase activity	nucleus|cytoplasm
YBR286W	APE3	hom	FT	PROTEOLYSIS	0.0257335435475104	0.136103013862348	608	Vacuolar aminopeptidase Y, processed to mature form by Prb1p	vacuolar protein catabolic process	aminopeptidase activity	fungal-type vacuole
YOR053W_d	YOR053W	hom			0.0257146723305566	0.136800326627317	609	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C	Unknown	Unknown	Unknown
YGR064W_d	YGR064W	hom	FF		0.0257102982655831	0.136457246341346	610	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C	Unknown	Unknown	Unknown
YKL198C	PTK1	hom	FT	PROTEIN PHOSPHORYLATION	0.0256881133055357	0.136795983591965	611	Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein	polyamine transport	protein kinase activity	cellular_component
YHR097C_p	YHR097C	hom	FT	NUCLEUS	0.0256744003793296	0.137005687311653	612	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YBR005W	RCR1	hom	FT	VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.025667001687021	0.137118934066651	613	Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication	fungal-type cell wall organization|vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane
YPL140C	MKK2	hom	FT	SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	0.025655205489196	0.137299639695834	614	MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication	signal transduction|peroxisome degradation|protein phosphorylation	MAP kinase kinase activity	intracellular
YDR309C	GIC2	hom	FT	CELL CYCLE|SIGNALING|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON	0.025642557935991	0.137845951473672	615	Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region	regulation of exit from mitosis|establishment of cell polarity|axial cellular bud site selection|Rho protein signal transduction	Rho GTPase binding|Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding	incipient cellular bud site|actin cap|plasma membrane|mating projection tip|cellular bud tip
YEL023C_p	YEL023C	hom			0.0256196612503166	0.138021494153248	616	Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene	biological_process	molecular_function	cellular_component
YBR185C	MBA1	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0255903031495116	0.138297162290979	617	Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane	protein insertion into mitochondrial membrane from inner side|mitochondrial respiratory chain complex III biogenesis|inner mitochondrial membrane organization|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	ribosome binding	mitochondrion|mitochondrial inner membrane
YBL040C	ERD2	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0255468110284274	0.139263615975636	618	HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins	protein retention in ER lumen|ER to Golgi vesicle-mediated transport	HDEL sequence binding	integral to endoplasmic reticulum membrane|integral to membrane
YNL090W	RHO2	hom	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE	0.0255129820964799	0.13949283089659	619	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly	microtubule-based process|fungal-type cell wall organization|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction	GTPase activity	membrane
YPR138C	MEP3	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0254589078848896	0.140333732613408	620	Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease	nitrogen utilization|ammonium transport	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YGR213C	RTA1	hom	FT	PLASMA MEMBRANE	0.0254160134586672	0.141003546447892	621	Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein	biological_process	molecular_function	integral to membrane|plasma membrane
YLR379W_d	YLR379W	het			0.0254151666786923	0.141016793942719	622	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C	Unknown	Unknown	Unknown
YOR203W_d	YOR203W	het			0.0253681261876431	0.141754224660359	623	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation	Unknown	Unknown	Unknown
YER134C	YER134C	hom	FT	NUCLEUS	0.0253514821594408	0.142015852961884	624	Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene	biological_process	acid phosphatase activity	nucleus|cytoplasm
YOL017W	ESC8	hom	FT	GENE SILENCING|NUCLEUS	0.0253097660468722	0.142673219425094	625	Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication	chromatin silencing	molecular_function	nucleus
YMR047C	NUP116	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0252911243334944	0.142967730984627	626	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p)	poly(A)+ mRNA export from nucleus|mRNA export from nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|nuclear pore organization|tRNA export from nucleus	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YCL025C	AGP1	hom	FT	PLASMA MEMBRANE	0.0252853885962946	0.143058440917824	627	Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity|L-proline transmembrane transporter activity	integral to membrane|plasma membrane
YPR092W_d	YPR092W	hom			0.0252812904869414	0.143421771493288	628	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL229C	SAP4	hom	FT	CELL CYCLE|MITOCHONDRION	0.0252210007282587	0.144079758031477	629	Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p	G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	mitochondrion|cytoplasm
YGL157W	ARI1	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEUS	0.0252038860562015	0.144352167840469	630	NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily	biological_process	oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YJL026W	RNR2	het	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|NUCLEUS	0.0251713219433463	0.144931510124739	631	Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits	deoxyribonucleotide biosynthetic process	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ribonucleoside-diphosphate reductase complex|nucleus|cytoplasm
YJR127C	RSF2	hom	FT	NUCLEUS	0.0251687490343092	0.144912671156466	632	Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YLR339C_d	YLR339C	het			0.0251569983925209	0.145460767339557	633	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0	Unknown	Unknown	Unknown
YGL153W	PEX14	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION	0.025149993998132	0.145212531586536	634	Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p	protein import into peroxisome matrix, docking	protein binding, bridging	peroxisomal membrane
YOR290C	SNF2	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|RSC COMPLEX	0.0250687916685876	0.146516298677999	635	Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|double-strand break repair|strand invasion|positive regulation of mating type switching|sucrose catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|nucleosome mobilization|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter	histone acetyl-lysine binding|RNA polymerase II activating transcription factor binding|DNA-dependent ATPase activity|nucleosomal DNA binding	SWI/SNF complex|nucleus
YDR013W	PSF1	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0250644047659065	0.146586987868837	636	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery	double-strand break repair via break-induced replication|DNA-dependent DNA replication	molecular_function	GINS complex|replication fork protection complex|DNA replication preinitiation complex
YDR420W	HKR1	hom	FT	CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0250349702067854	0.147242951829335	637	Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection	(1->3)-beta-D-glucan biosynthetic process|fungal-type cell wall organization|osmosensory signaling pathway via Sho1 osmosensor|hyperosmotic response|cellular bud site selection	osmosensor activity	site of polarized growth|plasma membrane
YLR224W_p	YLR224W	hom	FT	PROTEOLYSIS	0.0250056340655989	0.147536517319663	638	F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YDL239C	ADY3	hom	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION|NUCLEUS|CYTOSKELETON	0.0249762934103553	0.148375479144085	639	Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication	mitochondrion inheritance|ascospore wall assembly|sporulation resulting in formation of a cellular spore	molecular_function	spindle pole body|prospore membrane
YNL273W	TOF1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0249133889882566	0.149279003769359	640	Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase	DNA repair|DNA replication checkpoint|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|DNA replication|mitotic sister chromatid cohesion	molecular_function	nuclear chromosome|replication fork protection complex|nuclear replication fork
YIL129C	TAO3	het	FT	CELL DIVISION|MITOCHONDRION|SITE OF POLARIZED GROWTH	0.0248910778851189	0.149400842535762	641	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p	cell morphogenesis|cell budding|budding cell apical bud growth	molecular_function	incipient cellular bud site|mitochondrion|cellular bud|mating projection tip
YGL108C	YGL108C	hom			0.0248798182859557	0.149828065239036	642	Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cellular_component
YHL005C_d	YHL005C	hom			0.0248788626991906	0.149661406372798	643	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W	Unknown	Unknown	Unknown
YGR234W	YHB1	hom	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0248687766447448	0.150008991551232	644	Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	response to stress	nitric oxide reductase activity	cytosol|mitochondrion|mitochondrial matrix|cytoplasm
YGL232W	TAN1	hom	FT	RNA PROCESSING|NUCLEUS	0.0248549072832399	0.149993212141806	645	Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress	tRNA modification	RNA binding	nucleus|cytoplasm
YDR049W	VMS1	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0248453632347716	0.150149814162071	646	Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans	ER-associated protein catabolic process|mitochondria-associated protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process	molecular_function	cytosol|mitochondrion|endoplasmic reticulum membrane|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytoplasm
YOL029C_p	YOL029C	hom			0.0248333670803812	0.150346827916088	647	Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens	biological_process	molecular_function	cellular_component
YER013W	PRP22	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0248211222231231	0.150608994992926	648	DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes	spliceosomal complex disassembly|generation of catalytic spliceosome for second transesterification step	second spliceosomal transesterification activity|ATP-dependent RNA helicase activity	U2-type post-spliceosomal complex|U2-type catalytic step 2 spliceosome
YJL097W	PHS1	het	FT	KETONE METABOLISM|LIPID METABOLISM|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0248185453797219	0.150590517843298	649	Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking	vacuolar transport|sphingolipid biosynthetic process	enoyl-CoA hydratase activity	fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum|fungal-type vacuole|nuclear outer membrane-endoplasmic reticulum membrane network
YKL049C	CSE4	het	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE	0.0248052130228529	0.150809977849824	650	Centromere protein that resembles histone H3; required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p; Cse4p marks a subset of open chromatin; associated with promoters, accessible chromatin and RNA polymerase II-bound regions	2-micrometer plasmid partitioning|mitotic sister chromatid segregation	sequence-specific DNA binding|centromeric DNA binding	extrachromosomal circular DNA|nuclear nucleosome|condensed nuclear chromosome, centromeric region|centromere-specific nucleosome|kinetochore
YBL067C	UBP13	hom	FT	PROTEOLYSIS	0.0247936562121585	0.151000408178469	651	Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication	biological_process	ubiquitin-specific protease activity	cellular_component
YOR273C	TPO4	hom	FF|FT	PLASMA MEMBRANE	0.0247864720915671	0.1511188786622	652	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane	spermidine transport|spermine transport	spermidine transmembrane transporter activity|spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YBR089W_d	YBR089W	het			0.024744558018146	0.151811478788931	653	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30	Unknown	Unknown	Unknown
YDR358W	GGA1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0247180603794295	0.152250578260558	654	Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi	Golgi to vacuole transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to endosome transport	ubiquitin binding	trans-Golgi network
YDR099W	BMH2	hom	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.0247093509529278	0.152395115313662	655	14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	glycogen metabolic process|ascospore formation|Ras protein signal transduction|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|DNA damage checkpoint|DNA replication initiation|signal transduction involved in filamentous growth|pseudohyphal growth|fungal-type cell wall chitin biosynthetic process|pre-replicative complex assembly	DNA replication origin binding|phosphoserine binding	nucleus|plasma membrane
YDR263C	DIN7	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION	0.024700745369393	0.152905524161154	656	Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination	DNA repair	nuclease activity	mitochondrion
YNL325C	FIG4	hom	FT	LIPID METABOLISM	0.0246995987356517	0.152557081831861	657	Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	fungal-type vacuole membrane|PAS complex|extrinsic to membrane
YNR019W	ARE2	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0246419426319912	0.153762813011833	658	Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication	ergosterol metabolic process	ergosterol O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YOR076C	SKI7	hom	FT	TRANSLATION|NUCLEOTIDE METABOLISM	0.0246252794454341	0.153795693501938	659	Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay|nonfunctional rRNA decay	protein binding, bridging	Ski complex|cytoplasmic exosome (RNase complex)|cytoplasm
YNL249C	MPA43	hom	FT	CARBOHYDRATE METABOLISM|MITOCHONDRION	0.0245858825117228	0.154455377601626	660	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YMR136W	GAT2	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0245616013033721	0.154863024598837	661	Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YDL108W	KIN28	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME	0.0245527731718124	0.155072999339353	662	Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters	phosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase I promoter|protein phosphorylation|transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity|RNA polymerase II carboxy-terminal domain kinase activity|cyclin-dependent protein kinase activating kinase activity|protein kinase activity	TFIIK complex|holo TFIIH complex
YGL037C	PNC1	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING|NUCLEUS	0.0244860163083531	0.156137218118554	663	Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress	replicative cell aging|chromatin silencing at rDNA|nicotinate nucleotide salvage|chromatin silencing at telomere	nicotinamidase activity	nucleus|peroxisome|cytoplasm
YBR050C	REG2	hom	FT	TRANSCRIPTION FROM RNA POL II	0.0244776265890478	0.156279138731781	664	Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease	negative regulation of transcription from RNA polymerase II promoter	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex
YOL151W	GRE2	hom	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS	0.0244120514151277	0.157391781083938	665	3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress	ergosterol metabolic process|filamentous growth	methylglyoxal reductase (NADPH-dependent) activity|3-methylbutanol:NAD(P) oxidoreductase activity	nucleus|cytoplasm
YPR047W	MSF1	hom	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0243877548862836	0.157805550798037	666	Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase	phenylalanyl-tRNA aminoacylation|mitochondrial phenylalanyl-tRNA aminoacylation	phenylalanine-tRNA ligase activity	mitochondrion
YER133W	GLC7	het	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CELL DIVISION|CARBOHYDRATE METABOLISM	0.0243698899824404	0.15829647605351	667	Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest	replication fork processing|glycogen metabolic process|chromosome segregation|regulation of cell shape during vegetative growth phase|termination of RNA polymerase II transcription, poly(A)-coupled|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|rRNA processing|regulation of cell cycle|ascospore formation|protein localization to kinetochore|cell budding|DNA damage checkpoint|meiosis|termination of RNA polymerase II transcription, exosome-dependent|DNA replication checkpoint|response to heat|cellular ion homeostasis|histone dephosphorylation|regulation of carbohydrate metabolic process	protein serine/threonine phosphatase activity	protein phosphatase type 1 complex|mating projection base|condensed nuclear chromosome kinetochore|mRNA cleavage and polyadenylation specificity factor complex|nucleolus|spindle pole body|cellular bud neck
YPR151C	SUE1	hom	FT	PROTEOLYSIS|MITOCHONDRION	0.0243110032998952	0.159118040733962	668	Mitochondrial protein required for degradation of unstable forms of cytochrome c	protein catabolic process	molecular_function	mitochondrial envelope
YDR050C	TPI1	het	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.0243049330962948	0.159284385041904	669	Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease	glycolysis	triose-phosphate isomerase activity	mitochondrion|plasma membrane|cytoplasm
YNR051C	BRE5	hom	FT	VESICLE-MEDIATED TRANSPORT	0.0242385240616329	0.160365035358979	670	Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown	molecular_function	cytoplasm
YPR154W	PIN3	hom	FT	CYTOSKELETON ORGANIZATION|NUCLEUS	0.0242286023798597	0.160536309388967	671	Protein that induces appearance of [PIN+] prion when overproduced	actin cytoskeleton organization	molecular_function	nucleus|cytoplasm
YHR001W	OSH7	hom	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM	0.0242000018606594	0.161030802000432	672	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	maintenance of cell polarity|endocytosis|exocytosis|sterol transport|sterol metabolic process|late endosome to vacuole transport	lipid binding|oxysterol binding	integral to membrane|cortical endoplasmic reticulum|cytoplasm
YDR359C	EAF1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0241936643543963	0.161140530683959	673	Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1	DNA repair|cellular protein complex assembly|chromatin modification	molecular_function	histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YDR222W_p	YDR222W	hom	FT	RESPONSE TO OXIDATIVE STRESS	0.0241825139315201	0.161333728066485	674	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YDL050C_d	YDL050C	hom			0.0241816607045551	0.161348518670107	675	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR144C	NOC4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0241579191054878	0.161760487517849	676	Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits	ribosomal small subunit biogenesis|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	molecular_function	small-subunit processome|nucleolus|nucleus|90S preribosome|Noc4p-Nop14p complex
YIL057C	RGI2	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0241385677346546	0.162096863019619	677	Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose	energy reserve metabolic process	molecular_function	cytoplasm
YMR010W_p	YMR010W	hom			0.0241366721793919	0.162129840892836	678	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1	biological_process	molecular_function	integral to membrane|cytoplasm
YPR112C	MRD1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.024133260986908	0.162189199773797	679	Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|small-subunit processome assembly|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|90S preribosome
YOR370C	MRS6	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|PROTEIN PRENYLATION	0.024107695462454	0.162634592795715	680	Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress	protein targeting to membrane|protein geranylgeranylation|ER to Golgi vesicle-mediated transport|activation of Rab GTPase activity	Rab geranylgeranyltransferase activity|Rab GTPase binding	Rab-protein geranylgeranyltransferase complex|membrane|cytoplasm
YDR097C	MSH6	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0241049995881055	0.162681613013144	681	Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p	mismatch repair|meiotic mismatch repair	guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity|single base insertion or deletion binding|ATP binding	MutSalpha complex|nucleus
YDL032W_d	YDL032W	hom			0.0240886120933196	0.162967656815363	682	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene	Unknown	Unknown	Unknown
YJL013C	MAD3	hom	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS	0.0240690077817305	0.163310348044037	683	Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover	distributive segregation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	mitotic checkpoint complex
YBR163W	EXO5	hom	FT	MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.024064164528881	0.163395093638819	684	Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2	mitochondrial genome maintenance	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity	mitochondrion
YNL051W	COG5	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0240603341731554	0.164028309545585	685	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YML112W	CTK3	hom	FF|FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0240282426522867	0.164402347785732	686	Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress	mRNA 3'-end processing|positive regulation of translational fidelity|positive regulation of transcription from RNA polymerase I promoter|positive regulation of DNA-dependent transcription, elongation|protein phosphorylation	cyclin-dependent protein kinase activity	nucleoplasm|nucleolus|carboxy-terminal domain protein kinase complex
YDR331W	GPI8	het	FT	LIPID METABOLISM|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0240223902085541	0.164127422553465	687	ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog	attachment of GPI anchor to protein	GPI-anchor transamidase activity	endoplasmic reticulum membrane|GPI-anchor transamidase complex
YLL015W	BPT1	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	0.0240205146186535	0.164223255810566	688	ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p	cadmium ion transport|bilirubin transport	bilirubin transmembrane transporter activity|cadmium ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YPR068C	HOS1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS	0.0239466578982733	0.165461353423291	689	Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex	peptidyl-lysine deacetylation|histone H4 deacetylation|positive regulation of transcription from RNA polymerase II promoter	histone deacetylase activity|protein deacetylase activity	histone deacetylase complex
YNR064C	YNR064C	hom			0.0239121726717174	0.166071463211805	690	Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides	response to toxin	epoxide hydrolase activity	cellular_component
YHR106W	TRR2	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.0239086055450775	0.166134668915553	691	Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication	cellular response to oxidative stress|cell redox homeostasis	thioredoxin-disulfide reductase activity	mitochondrion
YGR210C_p	YGR210C	hom			0.0239002862828435	0.166282147690644	692	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YPL171C	OYE3	hom	FT	OXIDATION-REDUCTION PROCESS	0.0238755985476917	0.166720375993301	693	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death	apoptotic process	NADPH dehydrogenase activity	cellular_component
YMR303C	ADH2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	0.0238682228350384	0.166851469374553	694	Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1	ethanol metabolic process|NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	cytoplasm
YOL158C	ENB1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0238091577576984	0.167904066208057	695	Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment	ferric-enterobactin transport	ferric-enterobactin transmembrane transporter activity	integral to membrane|cellular bud membrane|plasma membrane
YLR372W	SUR4	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM|ENDOPLASMIC RETICULUM	0.0237937854034667	0.168178832101892	696	Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis	post-Golgi vesicle-mediated transport|fatty acid elongation|fatty acid biosynthetic process|sphingolipid biosynthetic process	fatty acid elongase activity	integral to membrane|endoplasmic reticulum
YDL139C	SCM3	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|PROTEOLYSIS|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0237500128664273	0.168963071853773	697	Nonhistone component of centromeric chromatin; binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation; homolog of mammalian HJURP	G2/M transition of mitotic cell cycle|chromosome segregation|protein localization to chromosome, centromeric region|Unknown	centromere-specific nucleosome binding	nucleus|condensed nuclear chromosome, centromeric region|cytoplasm
YNL038W	GPI15	het	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM	0.0237401689393431	0.16920338807324	698	Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein	GPI anchor biosynthetic process	phosphatidylinositol N-acetylglucosaminyltransferase activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane
YDL136W	RPL35B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0237087146593371	0.169896517500745	699	Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication	cytoplasmic translation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic large ribosomal subunit|preribosome, large subunit precursor
YJR151W-A_p	YJR151W-A	hom			0.0236874786146607	0.170343161186116	700	Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YPR041W	TIF5	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0236831034384011	0.170167133078403	701	Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2	mature ribosome assembly|negative regulation of translational initiation|regulation of translational initiation	translation initiation factor binding|GDP-dissociation inhibitor activity|GTPase activator activity|translation initiation factor activity	cytosolic small ribosomal subunit|multi-eIF complex
YJL071W	ARG2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0236787644245252	0.170245436684637	702	Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p	arginine biosynthetic process|ornithine biosynthetic process	acetyl-CoA:L-glutamate N-acetyltransferase activity	mitochondrial matrix
YEL042W	GDA1	hom	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0236646999568126	0.170499435311298	703	Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate	protein glycosylation	guanosine-diphosphatase activity|uridine-diphosphatase activity	Golgi apparatus
YML114C	TAF8	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0236508353468634	0.170750102259088	704	TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation	RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	nucleus|transcription factor TFIID complex
YOR371C	GPB1	hom	FT	SIGNALING|PROTEOLYSIS|PLASMA MEMBRANE	0.0236422502023884	0.170905456719544	705	Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication	positive regulation of Ras protein signal transduction|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of phosphorylation|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|invasive growth in response to glucose limitation|negative regulation of Ras protein signal transduction|protein polyubiquitination	cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding	plasma membrane|cytoplasm
YGR102C	GTF1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION	0.0236410157854069	0.17124711742412	706	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria	glutaminyl-tRNAGln biosynthesis via transamidation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YDR429C	TIF35	het	FF|FT	TRANSLATION	0.023625529643624	0.171208331142471	707	eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation	translation reinitiation|translational initiation	translation initiation factor activity	eukaryotic translation initiation factor 3 complex
YBR092C	PHO3	hom			0.0236158122938517	0.171384534656612	708	Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin	phosphate-containing compound metabolic process|thiamine-containing compound metabolic process	acid phosphatase activity	cell wall-bounded periplasmic space
YLR197W	NOP56	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.023606975299002	0.171864607895639	709	Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects	rRNA modification|rRNA processing	molecular_function	box C/D snoRNP complex|small-subunit processome|nucleolus|nucleus|90S preribosome
YOR228C	YOR228C	hom	FT	MITOCHONDRION	0.0235941803219322	0.1717772717935	710	Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to membrane
YKL190W	CNB1	hom	FF|FT	SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS	0.0235847377723332	0.171948915997911	711	Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding	calcineurin complex
YIL106W	MOB1	het	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON	0.0235641872812343	0.172322920820171	712	Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress	regulation of exit from mitosis|protein phosphorylation	kinase regulator activity	spindle pole body|cellular bud neck
YLR291C	GCD7	het	FT	TRANSLATION|MITOCHONDRION	0.0235185118913666	0.173156359342857	713	Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression	regulation of translational initiation	enzyme regulator activity|translation initiation factor activity|guanyl-nucleotide exchange factor activity	mitochondrion|eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YDL204W	RTN2	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0235115176442401	0.173284248779688	714	Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication	endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network maintenance	molecular_function	endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YKL055C	OAR1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0234901316922434	0.17367572752657	715	Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p	fatty acid metabolic process|aerobic respiration	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	mitochondrion
YPR110C	RPC40	het	FT	NUCLEUS	0.0234826248348186	0.173813300176249	716	RNA polymerase subunit AC40, common to RNA polymerase I and III	tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex
YNL318C	HXT14	hom	FT	MITOCHONDRION|PLASMA MEMBRANE	0.0234582091025076	0.174261312082321	717	Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	hexose transport	galactose transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YEL028W_d	YEL028W	hom			0.0234542840582982	0.174397659039858	718	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR403W	SFP1	hom	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|NUCLEUS	0.0234190863049741	0.174980984866176	719	Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion	positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of cell size|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription factor binding transcription factor activity	nucleus|cytoplasm
YPL132W	COX11	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION|RIBOSOME	0.0233670987684922	0.175940735041034	720	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p	protein complex assembly|aerobic respiration	copper ion binding	mitochondrial envelope|mitochondrion|mitochondrial ribosome|mitochondrial inner membrane
YBR219C_p	YBR219C	hom			0.0233184844157579	0.176841757307817	721	Putative protein of unknown function; YBR219C is not an essential gene	biological_process	molecular_function	integral to membrane
YLL005C	SPO75	hom	FT	CELL WALL ORG/BIOGENESIS	0.023317397448891	0.176861942443524	722	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis	ascospore wall assembly|ascospore formation	molecular_function	integral to membrane
YMR007W_d	YMR007W	hom			0.0233105838719569	0.176988510668125	723	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR422C	SIP1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION	0.0232868917268433	0.17742913829107	724	Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions	signal transduction|protein phosphorylation|regulation of protein complex assembly	AMP-activated protein kinase activity	AMP-activated protein kinase complex|fungal-type vacuole
YKR076W	ECM4	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS	0.0232780133167006	0.177594469550388	725	Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	fungal-type cell wall organization|glutathione metabolic process	glutathione transferase activity	cytoplasm
YOL050C_d	YOL050C	hom			0.0232692243908299	0.177758247368633	726	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	Unknown	Unknown	Unknown
YIL173W	VTH1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0232484142143606	0.178146484072847	727	Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting	Golgi to vacuole transport	signal sequence binding	endosome|integral to membrane
YKL107W_p	YKL107W	hom	FT	OXIDATION-REDUCTION PROCESS	0.0232105096299079	0.178855256057415	728	Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein	biological_process	molecular_function	cellular_component
YKL108W	SLD2	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.0231945699547228	0.179153934986206	729	Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; unphosphorylated or CDK-phosphorylated Sld2p binds to the MCM2-7 complex;required for the S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress	DNA replication preinitiation complex assembly|DNA strand renaturation|DNA replication initiation|double-strand break repair via break-induced replication|mitotic cell cycle DNA replication checkpoint	DNA replication origin binding|single-stranded DNA binding	DNA replication preinitiation complex
YOL049W	GSH2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0231817623363604	0.179459059974287	730	Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock	glutathione biosynthetic process	glutathione synthase activity	intracellular
YPL222W_p	FMP40	hom	FT	MITOCHONDRION	0.0231377897488193	0.180545994726452	731	Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YLR276C	DBP9	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0231297918255054	0.180436550808805	732	DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent DNA helicase activity|ATP-dependent DNA/RNA helicase activity|ATP-dependent RNA helicase activity	nucleolus
YMR170C	ALD2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0230999579109695	0.180934417876078	733	Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p	cellular aldehyde metabolic process|beta-alanine biosynthetic process|polyamine catabolic process	aldehyde dehydrogenase (NAD) activity	cytoplasm
YDR469W	SDC1	hom	FT	CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS	0.0230934528804215	0.181057315361964	734	Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30	histone H3-K4 methylation|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YNL045W	LAP2	hom	FT	KETONE METABOLISM|LIPID METABOLISM|PROTEOLYSIS|NUCLEUS	0.0230641894037826	0.181610947166056	735	Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	cellular lipid metabolic process|protein catabolic process	aminopeptidase activity|leukotriene-A4 hydrolase activity|epoxide hydrolase activity	nucleus|cytoplasm
YHR123W	EPT1	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0230587035920089	0.181714872110593	736	sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolaminephosphotransferase activity|diacylglycerol cholinephosphotransferase activity	integral to membrane|Golgi apparatus
YDR294C	DPL1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|SIGNALING|RESPONSE TO NUTRIENT LEVELS|ENDOPLASMIC RETICULUM	0.0230306598062994	0.182312034154857	737	Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate	calcium-mediated signaling|sphingolipid metabolic process|cellular response to starvation	sphinganine-1-phosphate aldolase activity	endoplasmic reticulum|cortical endoplasmic reticulum|perinuclear endoplasmic reticulum
YBR120C	CBP6	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0230163471475763	0.1825187712524	738	Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly	ribosome binding	mitochondrion|mitochondrial ribosome
YBL102W	SFT2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0229794753891334	0.183220717726169	739	Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5	Golgi to endosome transport	molecular_function	integral to membrane|Golgi membrane
YLR409C	UTP21	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0229628413950968	0.183538041242264	740	Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma	ribosomal small subunit biogenesis|rRNA processing	molecular_function	small-subunit processome|nucleolus|nucleus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YIL074C	SER33	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0228973360009948	0.184791632190184	741	3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication	serine family amino acid biosynthetic process	phosphoglycerate dehydrogenase activity	cytoplasm
YBR115C	LYS2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0228936529644573	0.184862302846317	742	Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p	lysine biosynthetic process via aminoadipic acid	L-aminoadipate-semialdehyde dehydrogenase activity	cytoplasm
YPR153W	YPR153W	hom			0.0228890688922179	0.184950290630648	743	Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YOR030W	DFG16	hom	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.0228756257596169	0.185536476320681	744	Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p	pseudohyphal growth|protein processing	molecular_function	integral to membrane
YPL176C	TRE1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|PLASMA MEMBRANE	0.0228556905718176	0.185591896104184	745	Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	molecular_function	fungal-type vacuole
YOR311C	DGK1	hom	FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0228185447115365	0.186373519022986	746	Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain	phosphatidic acid biosynthetic process	diacylglycerol kinase activity	integral to endoplasmic reticulum membrane|integral to membrane
YGR127W_p	YGR127W	hom			0.0228041225195908	0.186586380597743	747	Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response	biological_process	molecular_function	cellular_component
YFR020W_p	YFR020W	hom			0.0228013575951371	0.186705514154092	748	Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YML001W	YPT7	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT|MITOCHONDRION	0.0227985098384266	0.187023663772962	749	Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7	regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole inheritance|Golgi to vacuole transport|vesicle-mediated transport|endocytosis	GTPase activity	mitochondrial outer membrane|fungal-type vacuole
YDR279W	RNH202	hom	FT	NUCLEUS	0.0227665823021164	0.187312811123178	750	Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome	RNA catabolic process|DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus
YKR003W	OSH6	hom	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.0227542347877765	0.187552200098345	751	Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion	sterol homeostasis|maintenance of cell polarity|endocytosis|sterol transport|exocytosis|sterol metabolic process	phosphatidic acid binding|lipid binding|phosphatidylinositol-3,4-bisphosphate binding|oxysterol binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-4-phosphate binding	cortical endoplasmic reticulum|extrinsic to membrane|cytoplasm
YPL128C	TBF1	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0227238686583222	0.188141887354014	752	Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation	telomere maintenance via telomere lengthening|negative regulation of chromatin silencing|snoRNA transcription from an RNA polymerase II promoter|negative regulation of telomere maintenance via telomerase	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|chromatin insulator sequence binding|telomeric DNA binding	nuclear chromosome, telomeric region|nucleus
YFR038W	IRC5	hom	FT	NUCLEUS	0.0227227552190342	0.188163535460636	753	Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci	mitotic recombination	molecular_function	cellular_component
YLR307W	CDA1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.0226823508252055	0.189412588160805	754	Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall	ascospore wall assembly	chitin deacetylase activity	chitosan layer of spore wall
YOR019W	YOR019W	hom	FT	CELL CYCLE	0.0226651411336925	0.189286208798239	755	Protein of unknown function that may interact with ribosomes, based on co-purification experiments	mitochondrion degradation	molecular_function	ribosome
YOR285W	RDL1	hom	FT	ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0226638052419366	0.189312298522509	756	Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YHL017W_p	YHL017W	hom	FT	GOLGI APPARATUS	0.0226577818759049	0.189429966674937	757	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane|clathrin-coated vesicle
YOR173W	DCS2	hom			0.0226576592690031	0.189432362394692	758	Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance	deadenylation-dependent decapping of nuclear-transcribed mRNA	m7G(5')pppN diphosphatase activity	cytoplasmic mRNA processing body|cytoplasm
YDR482C	CWC21	hom	FT	RNA PROCESSING|NUCLEUS	0.0225989152278091	0.190648910173219	759	Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YIL170W	HXT12	hom			0.0225948335037587	0.190662906015008	760	Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family	hexose transport|biological_process	hexose transmembrane transporter activity|molecular_function	integral to membrane
YBR063C_p	YBR063C	hom			0.0225735755639242	0.191080605994898	761	Putative protein of unknown function; YBR063C is not an essential gene	biological_process	molecular_function	cellular_component
YNR072W	HXT17	hom	FT	PLASMA MEMBRANE	0.0225150753800797	0.192631779585441	762	Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose	hexose transport	mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YPR016C	TIF6	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS	0.0225073290182675	0.192386609883876	763	Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits	ribosomal subunit export from nucleus|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	ribosomal large subunit binding	nucleolus|nucleus|preribosome, large subunit precursor|cytoplasm
YBR116C_d	YBR116C	hom			0.0225053951554142	0.192424832908763	764	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2	Unknown	Unknown	Unknown
YEL011W	GLC3	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0224918539287396	0.192692633168172	765	Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	glycogen biosynthetic process	1,4-alpha-glucan branching enzyme activity	cytoplasm
YLR385C	SWC7	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.0224783975775569	0.192959025983691	766	Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin	chromatin remodeling	molecular_function	Swr1 complex|nucleus
YBR018C	GAL7	hom	FT	CARBOHYDRATE METABOLISM	0.022465175295446	0.193221048334517	767	Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism	galactose catabolic process via UDP-galactose	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	cytoplasm
YJL049W_p	YJL049W	hom	FT	PROTEIN LOCALIZATION	0.0224536464847155	0.193449724745072	768	Putative protein of unknown function; YJL049W is a non-essential gene	biological_process	molecular_function	cellular_component
YOR384W	FRE5	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION|PLASMA MEMBRANE	0.0224055001794199	0.194406864395964	769	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	ferric-chelate reductase activity	mitochondrion|integral to membrane
YJR124C_p	YJR124C	hom			0.0224053293343667	0.19441026693762	770	Putative protein of unknown function; expression induced under calcium shortage	biological_process	molecular_function	integral to membrane
YDL178W	DLD2	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0222890149224258	0.196736928924527	771	D-lactate dehydrogenase, located in the mitochondrial matrix	lactate metabolic process	actin binding|D-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial matrix
YPL106C	SSE1	hom			0.0222645631727465	0.197228624627586	772	ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication	protein folding|protein refolding	peptide binding|adenyl-nucleotide exchange factor activity|ATP binding	polysome|cytoplasm
YFL013C	IES1	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.0222570647858603	0.197914938369265	773	Subunit of the INO80 chromatin remodeling complex	nucleosome mobilization	molecular_function	nucleus|Ino80 complex
YNL013C_d	YNL013C	hom			0.0222563587039764	0.197460635284405	774	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W	Unknown	Unknown	Unknown
YJL111W	CCT7	het	FF		0.0222382025802249	0.1977597114098	775	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance	protein folding	unfolded protein binding	chaperonin-containing T-complex|cytoplasm
YPL168W_p	YPL168W	hom	FT	MITOCHONDRION	0.0222348755252962	0.197826815837303	776	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated	biological_process	molecular_function	mitochondrion
YIL039W	TED1	hom	FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0222260610854289	0.198004677567529	777	Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	ER to Golgi vesicle-mediated transport	molecular_function	endoplasmic reticulum
YPR160W	GPH1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0222221413872628	0.198217625058045	778	Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway	glycogen catabolic process	glycogen phosphorylase activity	cytoplasm
YER116C	SLX8	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0221703945919454	0.199130642606984	779	Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress	protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination	ubiquitin-protein ligase activity	ubiquitin ligase complex|nucleus
YLR365W_d	YLR365W	hom			0.0221387999935741	0.199838841464229	780	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene	Unknown	Unknown	Unknown
YNL284C	MRPL10	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0221143728823704	0.200402746092921	781	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDR145W	TAF12	het	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE	0.0220828183362102	0.200911501254768	782	Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A	histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter	TBP-class protein binding|chromatin binding|RNA polymerase II activating transcription factor binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YAR023C_p	YAR023C	hom			0.0220368877797132	0.201850127211043	783	Putative integral membrane protein, member of DUP240 gene family	biological_process	molecular_function	cellular_component
YIL023C	YKE4	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0220362406915002	0.20186337374084	784	Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family	zinc ion transport	zinc ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YER101C	AST2	hom	FT	PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS	0.0220335718049181	0.201918015158943	785	Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication	protein targeting to membrane	molecular_function	cytoplasm
YDL137W	ARF2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS|GOLGI APPARATUS	0.02196596183457	0.203305823813465	786	ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport	GTPase activity	cytosol|Golgi-associated vesicle
YDR340W_d	YDR340W	hom			0.0219658517164425	0.203308089822264	787	Putative protein of unknown function	Unknown	Unknown	Unknown
YLR145W	RMP1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0219614460259326	0.203398765120418	788	Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mRNA cleavage	ribonuclease MRP activity	nucleolus|nucleus|ribonuclease MRP complex|cytoplasm
YGR052W_p	FMP48	hom	FT	PROTEIN PHOSPHORYLATION|MITOCHONDRION	0.0219599536070816	0.203429487868756	789	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation	protein phosphorylation	protein kinase activity	mitochondrion
YPR142C_d	YPR142C	het			0.0219276926885521	0.204094432821922	790	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing	Unknown	Unknown	Unknown
YPR133W-A	TOM5	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0219133947749882	0.204592189048933	791	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore	mitochondrial outer membrane translocase complex assembly|protein targeting to mitochondrion	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YDR154C_d	YDR154C	hom			0.0218918227080488	0.204903151135161	792	Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein	Unknown	Unknown	Unknown
YCR101C_p	YCR101C	hom			0.0218348223681558	0.206085086275066	793	Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene	biological_process	molecular_function	integral to membrane|membrane
YBL044W_p	YBL044W	hom			0.021829011956725	0.206476700335374	794	Putative protein of unknown function; YBL044W is not an essential protein	biological_process	molecular_function	cellular_component
YGL061C	DUO1	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.0218008999974027	0.206790831584933	795	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis	mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization	microtubule binding|structural constituent of cytoskeleton	spindle microtubule|DASH complex|condensed nuclear chromosome kinetochore|spindle pole body|spindle
YBL062W_d	YBL062W	hom			0.0218005768610297	0.206729862156953	796	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR155C	NCA2	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.021720749767704	0.208397450479807	797	Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p	mRNA metabolic process|aerobic respiration	molecular_function	mitochondrial outer membrane|mitochondrion
YDR333C	RQC1	hom			0.0216529067667984	0.209822334804197	798	Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC	biological_process	molecular_function	cytoplasm
YPL032C	SVL3	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|SITE OF POLARIZED GROWTH	0.0216517873285275	0.210526795610503	799	Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress	endocytosis	molecular_function	cellular bud|cellular bud neck|cytoplasm
YMR083W	ADH3	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0216159660560752	0.210601146594168	800	Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production	NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	mitochondrion|mitochondrial matrix
YPR091C	NVJ2	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0216020902856555	0.210894225430329	801	Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments	biological_process	lipid binding	ribosome|nucleus-vacuole junction|endoplasmic reticulum
YKR052C	MRS4	hom	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.021597448773152	0.210992327506433	802	Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication	mitochondrial iron ion transport|RNA splicing	iron ion transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YPR101W	SNT309	hom	FT	RNA PROCESSING|NUCLEUS	0.0215859402083406	0.211235712516901	803	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p	mRNA splicing, via spliceosome	first spliceosomal transesterification activity	Prp19 complex|U2-type catalytic step 1 spliceosome
YGL117W_p	YGL117W	hom	FF		0.0215814066041265	0.211740619483131	804	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL137C	NAM9	het	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0213965896368214	0.21526929843963	805	Mitochondrial ribosomal component of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YNL020C	ARK1	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0213536114552996	0.216260995298631	806	Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication	regulation of endocytosis|actin filament organization|protein phosphorylation|cytokinesis|actin cortical patch assembly	protein serine/threonine kinase activity|protein kinase activity	mating projection tip|actin cortical patch
YER095W	RAD51	hom	FF|FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0213512065815342	0.216244245183937	807	Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein	strand invasion|telomere maintenance via recombination|heteroduplex formation|meiotic joint molecule formation|reciprocal meiotic recombination|double-strand break repair via single-strand annealing	recombinase activity|single-stranded DNA binding|DNA-dependent ATPase activity	condensed nuclear chromosome|nuclear chromosome
YGL151W	NUT1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION	0.0213118417724454	0.217092474076296	808	Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription	regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	molecular_function	mitochondrion|mediator complex|nucleus
YNL014W	HEF3	hom	FT	TRANSLATION|NUCLEOTIDE METABOLISM|RIBOSOME	0.0212900129686759	0.217563868783086	809	Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication	translational elongation	ATPase activity|translation elongation factor activity	cytosolic ribosome
YJL146W	IDS2	hom	FT	CELL CYCLE|NUCLEUS	0.0212685964106097	0.218027075554017	810	Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation	meiosis	molecular_function	nucleus|cytoplasm
YDR251W	PAM1	hom	FT	OXIDATION-REDUCTION PROCESS|SITE OF POLARIZED GROWTH	0.0212582098813954	0.218251974949567	811	Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype	pseudohyphal growth	molecular_function	cellular bud|cellular bud neck
YMR326C_d	YMR326C	hom			0.0212480234643738	0.218472703123502	812	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13	Unknown	Unknown	Unknown
YBR089C-A	NHP6B	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0212409638738705	0.218625770515812	813	High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication	RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling|transcription from RNA polymerase II promoter	nucleosome binding|DNA binding, bending|sequence-specific DNA binding	nucleus
YCR098C	GIT1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0212260577168712	0.218949221591769	814	Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability	transmembrane transport|glycerophosphodiester transport	glycerophosphodiester transmembrane transporter activity	integral to membrane|plasma membrane
YOL094C	RFC4	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0212178688059481	0.21912706020308	815	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon	mismatch repair|sister chromatid cohesion|leading strand elongation	DNA clamp loader activity	Elg1 RFC-like complex|Rad17 RFC-like complex|DNA replication factor C complex|Ctf18 RFC-like complex
YBR065C	ECM2	hom	FT	RNA PROCESSING|NUCLEUS	0.021214015975474	0.219210767993098	816	Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p	mRNA splicing, via spliceosome	molecular_function	nucleus
YLR118C	YLR118C	hom	FT	KETONE METABOLISM|LIPID METABOLISM|NUCLEUS	0.0211850691260407	0.219840410222505	817	Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS	protein deacylation	palmitoyl-(protein) hydrolase activity	nucleus|cytoplasm
YPL202C	AFT2	hom	FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|MITOCHONDRION	0.0211688499148921	0.220262572234591	818	Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication	cellular response to oxidative stress|cellular iron ion homeostasis|positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	mitochondrion|nucleus
YAL017W	PSK1	hom	FT	SIGNALING|TRANSLATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0211565632877258	0.220461726444827	819	PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication	regulation of (1->6)-beta-D-glucan biosynthetic process|negative regulation of glycogen biosynthetic process|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YPL083C	SEN54	het	FT	RNA PROCESSING|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	0.0211469198470814	0.220672200580646	820	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p	tRNA-type intron splice site recognition and cleavage	tRNA-intron endonuclease activity	mitochondrial outer membrane|mitochondrion|tRNA-intron endonuclease complex
YMR246W	FAA4	hom	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	0.021142750648608	0.220763240530369	821	Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication	long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process	long-chain fatty acid-CoA ligase activity	lipid particle|cytoplasm
YPL120W	VPS30	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	0.0211334700324378	0.221034849882635	822	Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1	phosphatidylinositol biosynthetic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|retrograde transport, endosome to Golgi|macroautophagy|CVT pathway|late endosome to vacuole transport	1-phosphatidylinositol-3-kinase activity	phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|extrinsic to membrane|cytoplasm
YHR035W_p	YHR035W	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM	0.0211123125197712	0.221428712969549	823	Putative protein of unknown function; not an essential gene	biological_process	molecular_function	cellular_component
YNL203C_d	YNL203C	hom			0.0211092366741894	0.221496040399337	824	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL260C	LTO1	het	FT	NUCLEUS	0.0210695243111997	0.222366624494999	825	Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species	biological_process	molecular_function	nucleus|cytoplasm
YML104C	MDM1	hom	FT	MITOCHONDRION ORGANIZATION|CYTOSKELETON	0.0210639575418304	0.222695843258346	826	Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)	nuclear migration|mitochondrion inheritance|mitochondrion organization	structural constituent of cytoskeleton|phosphatidylinositol-3-phosphate binding	intermediate filament|integral to membrane|cytoplasm
YBR152W	SPP381	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0210549095285261	0.222687628981151	827	mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p	mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step	molecular_function	U4/U6 x U5 tri-snRNP complex
YMR162C	DNF3	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|GOLGI APPARATUS	0.0210099326364298	0.223677597939307	828	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase	intracellular protein transport|phospholipid translocation	phospholipid-translocating ATPase activity	trans-Golgi network transport vesicle|integral to membrane
YER121W_p	YER121W	hom			0.0209831520117229	0.224545093972222	829	Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy	biological_process	molecular_function	cellular_component
YFL048C	EMP47	hom	FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0209623967367226	0.224727307630867	830	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport	ER to Golgi vesicle-mediated transport	glycoprotein binding	fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YJR135W-A	TIM8	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0209604616289545	0.224770113976543	831	Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome	protein import into mitochondrial inner membrane	protein transporter activity	mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex
YLR036C_p	YLR036C	hom			0.0209579504448666	0.224825672336052	832	Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein	biological_process	molecular_function	integral to membrane
YER162C	RAD4	hom	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS	0.020955146148631	0.224887727206598	833	Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins	proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair	damaged DNA binding	cytosol|nucleotide-excision repair factor 2 complex|nucleus
YLR279W_d	YLR279W	hom			0.0209312256373041	0.225417549421509	834	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR222W	PET54	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0209199500501286	0.225875270773217	835	Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing	Group I intron splicing|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	translation regulator activity|RNA binding	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial inner membrane|mitochondrial matrix
YDL215C	GDH2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0208629092825741	0.227212901877026	836	NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels	nitrogen compound metabolic process	glutamate dehydrogenase (NAD+) activity	mitochondrion
YDR262W_p	YDR262W	hom			0.0208284504790771	0.227704082135179	837	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment	biological_process	molecular_function	fungal-type vacuole
YJL132W_p	YJL132W	hom			0.0208159396990281	0.227983544813538	838	Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene	biological_process	molecular_function	membrane
YOR308C	SNU66	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.020791220185903	0.228536441017262	839	Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1	maturation of 5S rRNA|mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YLR219W	MSC3	hom	FT	CELL CYCLE|PLASMA MEMBRANE	0.0207716653403548	0.228974495808578	840	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress	reciprocal meiotic recombination	molecular_function	cellular_component
YGR250C	YGR250C	hom			0.0207647757645794	0.229894126489277	841	Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress	biological_process	RNA binding	cytoplasmic stress granule|cytoplasm
YKL164C	PIR1	hom	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	0.0207344268790693	0.229810338708682	842	O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication	intracellular protein transport|fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall
YDL187C_d	YDL187C	hom			0.0207044591539227	0.230484558509929	843	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAL007C	ERP2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0207021184613437	0.23053727898926	844	Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles	ER to Golgi vesicle-mediated transport	molecular_function	ER to Golgi transport vesicle
YNR075W	COS10	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0206888038336785	0.230906878151146	845	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	endocytosis	molecular_function	nuclear envelope|integral to membrane|endoplasmic reticulum|cytoplasm
YHR113W	APE4	hom	FT	PROTEOLYSIS	0.0206807305100798	0.231019406372044	846	Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family	proteolysis	aminopeptidase activity	fungal-type vacuole lumen|ribosome|cytoplasm
YIL034C	CAP2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0206769970664646	0.231103639047145	847	Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress	barbed-end actin filament capping|filamentous growth	actin filament binding	actin filament|F-actin capping protein complex|mating projection tip|actin cortical patch
YIR015W	RPR2	het	FT	RNA PROCESSING|NUCLEUS	0.0206690029219979	0.231284073538951	848	Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress	tRNA processing|intronic box C/D snoRNA processing	ribonuclease P activity	nucleolar ribonuclease P complex
YGR157W	CHO2	hom	FT	LIPID METABOLISM	0.0206612847219435	0.232085548621362	849	Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis	phosphatidylcholine biosynthetic process	phosphatidylethanolamine N-methyltransferase activity	integral to membrane|endoplasmic reticulum
YHL007C	STE20	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH	0.0206595146234605	0.231498362121507	850	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p	negative regulation of gene expression|osmosensory signaling pathway via Sho1 osmosensor|activation of MAPKKK activity|vacuole inheritance|protein phosphorylation|cellular bud site selection|cellular response to heat|regulation of exit from mitosis|pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|pseudohyphal growth|sterol import|stress granule assembly|invasive growth in response to glucose limitation|positive regulation of apoptotic process	histone serine kinase activity|MAP kinase kinase kinase kinase activity|protein kinase activity	incipient cellular bud site|plasma membrane|nucleus|mating projection tip
YCL001W-B_p	YCL001W-B	hom			0.0206469998211472	0.231781218313174	851	Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLR070C	XYL2	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM	0.0206399527492844	0.231940602240428	852	Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect	xylulose biosynthetic process	D-xylulose reductase activity	cellular_component
YMR216C	SKY1	hom	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS	0.0206092819616105	0.232635190605172	853	SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1	cellular cation homeostasis|cellular ion homeostasis|response to drug|protein phosphorylation|positive regulation of protein import into nucleus|regulation of cell size|mRNA splice site selection	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YGR103W	NOP7	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0205927755263049	0.233009614865836	854	Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation	ribosomal large subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cell cycle	molecular_function	PeBoW complex|nucleolus|nucleus|preribosome, large subunit precursor
YGL111W	NSA1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0205844162244436	0.233199396244796	855	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis	ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YLR048W	RPS0B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME	0.0205753089310553	0.233406283971149	856	Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YMR210W	YMR210W	hom	FT	KETONE METABOLISM|LIPID METABOLISM	0.0205540234321905	0.233890327634328	857	Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification	medium-chain fatty acid biosynthetic process	transferase activity, transferring acyl groups	cellular_component
YGR112W	SHY1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0205480686838521	0.234025869010794	858	Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome	mitochondrial respiratory chain complex IV assembly|aerobic respiration	unfolded protein binding	mitochondrion|integral to membrane|mitochondrial inner membrane
YLR444C_d	YLR444C	hom			0.0205264402026203	0.234518642299201	859	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR196W	PWP1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0205184336420104	0.234701246241357	860	Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily	rRNA processing	molecular_function	nucleolus|nucleus|cytoplasm
YPR140W	TAZ1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0205005133948084	0.235249967212718	861	Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome	cardiolipin acyl-chain remodeling|mitochondrial ATP synthesis coupled electron transport|protein complex assembly|inner mitochondrial membrane organization|cardiolipin metabolic process|phospholipid biosynthetic process	1-acylglycerophosphocholine O-acyltransferase activity	mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YMR088C	VBA1	hom			0.0204675337180844	0.238395289139568	862	Permease of basic amino acids in the vacuolar membrane	basic amino acid transport	basic amino acid transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YLR342W	FKS1	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON	0.0204394107108451	0.23650890578768	863	Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling	(1->3)-beta-D-glucan biosynthetic process|positive regulation of endocytosis|regulation of cell size	1,3-beta-D-glucan synthase activity	mitochondrion|1,3-beta-D-glucan synthase complex|integral to membrane|plasma membrane|cellular bud neck|cellular bud tip|actin cortical patch
YJR006W	POL31	het	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0204367671023446	0.236569548290847	864	Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair	mismatch repair|RNA-dependent DNA replication|lagging strand elongation|base-excision repair|postreplication repair|DNA replication, removal of RNA primer|leading strand elongation|nucleotide-excision repair	single-stranded DNA specific 3'-5' exodeoxyribonuclease activity|DNA-directed DNA polymerase activity	delta DNA polymerase complex
YDL088C	ASM4	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0204123445679139	0.237130303616542	865	FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication	nuclear pore organization|mRNA export from nucleus in response to heat stress|mitotic cell cycle spindle assembly checkpoint	nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding	nuclear pore central transport channel|integral to membrane|nuclear pore
YJR105W	ADO1	hom	FF|FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.0203848681722027	0.238463151924509	866	Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle	purine nucleobase metabolic process	adenosine kinase activity	nucleus|cytoplasm
YIL105C	SLM1	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION|MITOCHONDRION|PLASMA MEMBRANE	0.0203430771403068	0.238725828811045	867	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol binding|sphingolipid binding	eisosome|mitochondrion|membrane raft|plasma membrane|cytoplasm
YEL003W	GIM4	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS	0.0203402937737668	0.239421291763588	868	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it	tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YPL226W	NEW1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|NUCLEUS|MITOCHONDRION	0.0202868602270825	0.240026299924589	869	ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction	ribosomal small subunit biogenesis|poly(A)+ mRNA export from nucleus	ATPase activity|ATP binding	mitochondrion|polysome|cytoplasm
YPR014C_d	YPR014C	hom			0.0202644185413641	0.240546836908319	870	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene	Unknown	Unknown	Unknown
YBL058W	SHP1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION|NUCLEUS	0.0202380076481318	0.241511541778036	871	UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate	glycogen metabolic process|proteasomal ubiquitin-dependent protein catabolic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|ascospore formation|sister chromatid biorientation|autophagic vacuole assembly	protein phosphatase type 1 regulator activity	nucleus|cytoplasm
YDL119C_p	YDL119C	hom	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.0202212707544695	0.241549886179317	872	Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria	transport	transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YHR029C	YHI9	hom	FT	SIGNALING	0.0201984290023233	0.242574122054046	873	Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production	endoplasmic reticulum unfolded protein response	molecular_function	cellular_component
YJL197W	UBP12	hom	FT	PROTEOLYSIS|NUCLEUS	0.020170424588478	0.242735670933256	874	Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm	biological_process	ubiquitin-specific protease activity	nucleus|cytoplasm
YBL009W	ALK2	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	0.0201680906201817	0.242790199502621	875	Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins	meiosis|mitosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YNL041C	COG6	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0201554218929264	0.243297222218435	876	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YNR014W_p	YNR014W	hom			0.0201520492358338	0.243165207745053	877	Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YFR051C	RET2	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0201486611785611	0.243244464240078	878	Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER	retrograde vesicle-mediated transport, Golgi to ER|Golgi inheritance|ER to Golgi vesicle-mediated transport|Golgi localization	molecular_function	COPI vesicle coat
YNR054C	ESF2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0201414072084289	0.243414216675052	879	Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|small-subunit processome assembly|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATPase activator activity|RNA binding	nucleolus|90S preribosome|cytoplasm
YBR072W	HSP26	hom	FT	NUCLEUS	0.0201375322174925	0.243504930643995	880	Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity	protein folding|response to stress	unfolded protein binding|mRNA binding	nucleus|cytoplasm
YKL170W	MRPL38	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0201186798450183	0.243946605524122	881	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YHR121W	LSM12	hom	FT	NUCLEUS	0.0200667667316346	0.24516573573162	882	Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress	RNA metabolic process	RNA binding	ribosome|nucleus|cytoplasmic stress granule|cytoplasm
YLL038C	ENT4	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0200646242954944	0.245216140450447	883	Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome	endocytosis|actin filament organization|establishment of protein localization to plasma membrane|actin cortical patch assembly	clathrin binding	actin cortical patch
YIL027C	EMC5	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.020039621336735	0.245875334520996	884	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YHL047C	ARN2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM|PLASMA MEMBRANE	0.020036148495231	0.245886775837244	885	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C	cellular iron ion homeostasis|siderophore transport|siderophore metabolic process	siderophore transmembrane transporter activity	endosome|integral to membrane|cytoplasmic membrane-bounded vesicle|plasma membrane
YJL158C	CIS3	hom	FT	CELL WALL ORG/BIOGENESIS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0200344569207887	0.245926654621161	886	Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family	fungal-type cell wall organization	structural constituent of cell wall	extracellular region|fungal-type cell wall|endoplasmic reticulum|plasma membrane|cellular bud tip
YML061C	PIF1	hom	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|NUCLEUS|MITOCHONDRION	0.0200295093017944	0.246395711271721	887	DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells	chromosome organization|negative regulation of telomere maintenance via telomerase|telomere maintenance|mitochondrial genome maintenance|DNA recombination	DNA helicase activity|telomerase inhibitor activity	mitochondrion|nucleus|mitochondrial membrane
YKL073W	LHS1	hom	FT	PROTEIN LOCALIZATION|NUCLEOTIDE METABOLISM|ENDOPLASMIC RETICULUM	0.0200108633184952	0.246483345145387	888	Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway	posttranslational protein targeting to membrane, translocation|response to unfolded protein	unfolded protein binding|adenyl-nucleotide exchange factor activity|ATP binding	endoplasmic reticulum lumen
YCL021W-A_p	YCL021W-A	hom			0.019995466235392	0.247058598371416	889	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YAL009W	SPO7	hom	FF|FT	CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0199775692591585	0.247340909835293	890	Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|integral to membrane
YDL159W-A_p	YDL159W-A	hom			0.019956835504954	0.247761453369138	891	Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	cellular_component
YPL225W	YPL225W	hom			0.0199554480690473	0.247794336179527	892	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|cytoplasm
YOL030W	GAS5	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.019952613851417	0.24786151780959	893	1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall	(1->3)-beta-D-glucan metabolic process	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane
YJL054W	TIM54	het	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0199343969863142	0.248293630259914	894	Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane	protein import into mitochondrial inner membrane	protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YKL185W	ASH1	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.0199046025463295	0.249001502995459	895	Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate	Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|core promoter proximal region sequence-specific DNA binding	Rpd3L-Expanded complex|nucleus|cellular bud|Rpd3L complex
YDR167W	TAF10	het	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE	0.0198689086616419	0.249851393329806	896	Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification	histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter	chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|protein complex scaffold	SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YNL114C_d	YNL114C	het			0.0198375074415089	0.250600746183122	897	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit	Unknown	Unknown	Unknown
YBR113W_d	YBR113W	hom			0.0198225639039069	0.250957906200033	898	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8	Unknown	Unknown	Unknown
YDR153C	ENT5	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM	0.0197887106387259	0.25176833368865	899	Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin	late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|Golgi to endosome transport	clathrin binding|phosphatidylinositol-3,5-bisphosphate binding	endosome|clathrin vesicle coat|cytoplasm
YDL163W_d	YDL163W	het			0.0197767997106962	0.252053907776933	900	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase	Unknown	Unknown	Unknown
YGR024C	THG1	het	FT	RNA PROCESSING|NUCLEUS	0.0197699088447988	0.252219224874355	901	tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes	tRNA modification	tRNA guanylyltransferase activity	nucleus|cytoplasm
YBL103C	RTG3	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|SIGNALING|NUCLEUS	0.0197630762377627	0.252383218880887	902	Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways	mitochondrion degradation|cellular response to oleic acid|mitochondria-nucleus signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription factor import into nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus|cytoplasm
YDR023W	SES1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.0197583657504945	0.252496321714108	903	Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p	seryl-tRNA aminoacylation	serine-tRNA ligase activity	cytoplasm
YIL014C-A_p	YIL014C-A	hom			0.0197381460278522	0.252982215627307	904	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YER014C-A	BUD25	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	0.0197298313120492	0.25318221279373	905	Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern	cellular bud site selection	molecular_function	cellular_component
YDR367W	KEI1	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0197239953068052	0.253393435858513	906	Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene	inositolphosphoceramide metabolic process	inositol phosphoceramide synthase regulator activity	integral to membrane|Golgi apparatus|integral to Golgi membrane|inositol phosphoceramide synthase complex|cytoplasm
YMR213W	CEF1	het	FT	CELL CYCLE|RNA PROCESSING|NUCLEUS	0.0196915115757695	0.254105355172874	907	Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p	mRNA splicing, via spliceosome	first spliceosomal transesterification activity	Prp19 complex|U2-type catalytic step 1 spliceosome
YEL012W	UBC8	hom	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	0.0196392849519201	0.255367287968913	908	Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YPL131W	RPL5	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0196242766878741	0.256440709225338	909	Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YDL236W	PHO13	hom	FT	NUCLEUS	0.0196032414271472	0.256240729970952	910	Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity	protein dephosphorylation	4-nitrophenylphosphatase activity|phosphoprotein phosphatase activity|alkaline phosphatase activity	nucleus|cytoplasm
YDL144C	YDL144C	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEUS	0.0196024787522088	0.256259234238006	911	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YFR022W	ROG3	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	0.0196003753528038	0.256665083002705	912	Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; ROG3 has a paralog, ROD1, that arose from the whole genome duplication	ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	cellular_component
YBR058C	UBP14	hom	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS	0.0195952020628701	0.256435830289407	913	Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T	protein deubiquitination|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	cytoplasm
YBL023C	MCM2	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0195830550755929	0.256730810485609	914	Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress	S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|pre-replicative complex assembly|double-strand break repair via break-induced replication	chromatin binding|DNA replication origin binding|DNA helicase activity|single-stranded DNA binding	replication fork protection complex|nucleus|DNA replication preinitiation complex|pre-replicative complex|cytoplasm|MCM complex
YNL233W	BNI4	hom	FT	PROTEIN LOCALIZATION|CELL DIVISION|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0195802060388905	0.256800031217496	915	Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p	asymmetric protein localization|barrier septum assembly|chitin biosynthetic process	protein binding	incipient cellular bud site|cellular bud neck septin collar|cellular bud neck|septin ring
YDL148C	NOP14	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION	0.019566812552823	0.257125615418039	916	Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit biogenesis|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	snoRNA binding	small-subunit processome|mitochondrion|nucleolus|90S preribosome|Noc4p-Nop14p complex
YMR161W	HLJ1	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0195607065105332	0.257274143080581	917	Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ	ER-associated protein catabolic process	ATPase activator activity	endoplasmic reticulum|endoplasmic reticulum membrane
YJR008W	MHO1	hom	FT	NUCLEUS	0.019555972274175	0.257744382737089	918	Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility	biological_process	molecular_function	nucleus|cytoplasm
YJL142C_d	IRC9	hom			0.0195281404630694	0.258067307524234	919	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci	Unknown	Unknown	Unknown
YDR022C	ATG31	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|CHROMOSOME SEGREGATION|CYTOSKELETON	0.0195142999358703	0.258404914056779	920	Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion	autophagy|mitochondrion degradation|piecemeal microautophagy of nucleus	molecular_function	pre-autophagosomal structure|cytoplasm
YOR235W_d	IRC13	hom			0.0195089209075993	0.258536205118692	921	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci	Unknown	Unknown	Unknown
YOL132W	GAS4	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PLASMA MEMBRANE	0.0195087329334913	0.258540794017211	922	1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall	ascospore wall assembly	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane
YIL158W	AIM20	hom	FT	CELL CYCLE	0.0195042589014823	0.258650032517758	923	Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress	biological_process	molecular_function	fungal-type vacuole
YNR002C	ATO2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION|PLASMA MEMBRANE	0.019502448504394	0.258694244474939	924	Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication	ammonium transport|nitrogen utilization	ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YOL018C	TLG2	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0194900545763599	0.2602077904218	925	Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)	inositolphosphoceramide metabolic process|Golgi to vacuole transport|endocytosis|mannosyl-inositol phosphorylceramide metabolic process|protein exit from endoplasmic reticulum|vesicle fusion|CVT pathway	SNAP receptor activity	SNARE complex|trans-Golgi network|integral to endosome membrane
YMR081C	ISF1	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0193960381240694	0.261302107858089	926	Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant	aerobic respiration	molecular_function	cellular_component
YOR034C-A_p	YOR034C-A	hom			0.0193737286280423	0.261922295569361	927	Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YBR136W	MEC1	het	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|MITOCHONDRION	0.0193438099798936	0.262588719130565	928	Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres	histone phosphorylation|telomere maintenance via recombination|telomere maintenance|nucleobase-containing compound metabolic process|reciprocal meiotic recombination|DNA recombination|DNA damage checkpoint|DNA replication|DNA damage induced protein phosphorylation	protein kinase activity	mitochondrion|nucleus
YCL038C	ATG22	hom	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	0.0193246272421028	0.263062371350819	929	Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation	amino acid export from vacuole	molecular_function	integral to fungal-type vacuolar membrane|integral to membrane
YBR227C	MCX1	hom	FT	MITOCHONDRION	0.0193236700576283	0.263086021184298	930	Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins	protein refolding	molecular_function	mitochondrion|mitochondrial matrix
YMR261C	TPS3	hom	FT	CARBOHYDRATE METABOLISM	0.0193142262043581	0.263319435777824	931	Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication	trehalose biosynthetic process|response to stress	enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YLL030C_d	RRT7	hom			0.0193105627753906	0.263410019653561	932	Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNR074C	AIF1	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|MITOCHONDRION|PLASMA MEMBRANE	0.0192539300694421	0.264813084437682	933	Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase	response to singlet oxygen|positive regulation of apoptotic process	oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor	mitochondrion|nucleus|plasma membrane
YDL188C	PPH22	hom	FT	CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|CHROMOSOME	0.0192461262980882	0.265291997453325	934	Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication	actin filament organization|budding cell bud growth|G1/S transition of mitotic cell cycle|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|regulation of translation	protein serine/threonine phosphatase activity	condensed nuclear chromosome, centromeric region
YFL049W	SWP82	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RSC COMPLEX	0.0192189676450794	0.265753119392056	935	Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex|nucleus
YMR276W	DSK2	hom	FT	CELL CYCLE|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|NUCLEUS	0.0192127500347817	0.265836539259893	936	Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process|spindle pole body duplication associated with nuclear envelope	protein binding, bridging	nucleus
YLR438W	CAR2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0192120173699225	0.265854772924445	937	L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress	ornithine metabolic process|arginine catabolic process	ornithine-oxo-acid transaminase activity	cytosol|nucleus|cytoplasm
YDR084C	TVP23	hom	FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0192046368066064	0.266038499337927	938	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|cytoplasm
YPL250C	ICY2	hom			0.0191623501395105	0.267092837164734	939	Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate	mitochondrion degradation	molecular_function	cellular_component
YGR098C	ESP1	het	FT	CELL CYCLE|LIPID METABOLISM|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CYTOSKELETON	0.0191582371440863	0.267195539961028	940	Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress	regulation of exit from mitosis|regulation of mitotic spindle elongation|negative regulation of protein phosphatase type 2A activity|apoptotic process|mitotic sister chromatid segregation	cysteine-type endopeptidase activity	mitochondrion|nucleus|cytoplasm|spindle
YCR077C	PAT1	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|TRANSLATION|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|RIBOSOME	0.0191558124192799	0.267398796231651	941	Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|chromosome segregation|regulation of translational initiation|formation of translation preinitiation complex|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly	molecular_function	cytosolic small ribosomal subunit|cytoplasmic mRNA processing body
YMR280C	CAT8	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0191418246694343	0.267605634888581	942	Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of glyoxylate cycle by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDR152W	GIR2	hom	FT	TRANSLATION	0.019141565546792	0.267826231255914	943	Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein	cytoplasmic translation	molecular_function	polysome|cytoplasm
YGR075C	PRP38	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0191406667134185	0.267705934603932	944	Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	molecular_function	U4/U6 x U5 tri-snRNP complex
YMR272W-B_p	YMR272W-B	hom			0.0190967323832772	0.26873457145551	945	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YKL117W	SBA1	hom	FT	NUCLEUS	0.019076577825238	0.269311622796846	946	Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress	protein folding|positive regulation of telomere maintenance via telomerase|regulation of telomerase activity	chaperone binding	nucleus|cytoplasm
YOL008W	COQ10	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0190736532994413	0.269313645416788	947	Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes	cellular respiration	ubiquinone binding	mitochondrion|mitochondrial inner membrane
YDR098C	GRX3	hom	FT	ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0190724746561395	0.269700512796408	948	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36	cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization	disulfide oxidoreductase activity	cytosol|nucleus
YKL147C_d	YKL147C	hom			0.019062913141191	0.26958341682316	949	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3	Unknown	Unknown	Unknown
YGR071C	ENV11	hom	FT	VACUOLAR PROTEIN PROCESSING|NUCLEUS	0.0189915531789639	0.271380543108329	950	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	vacuole organization|vacuolar protein processing	molecular_function	nucleus
YBR109C	CMD1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0189863797468217	0.271511148751457	951	Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin	karyogamy involved in conjugation with cellular fusion|phosphatidylinositol biosynthetic process|NLS-bearing substrate import into nucleus|microautophagy|cell budding|vacuole fusion, non-autophagic|receptor-mediated endocytosis|cytoskeleton organization|spindle pole body organization|transcription factor import into nucleus	calcium-dependent protein binding|protein binding|calcium ion binding	incipient cellular bud site|central plaque of spindle pole body|mating projection tip|cellular bud neck|cellular bud tip
YGL149W_d	YGL149W	hom			0.0189664787656754	0.272013959158496	952	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.	Unknown	Unknown	Unknown
YNL035C	YNL035C	hom	FT	NUCLEUS	0.0189471019791276	0.272504137325913	953	Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YNL294C	RIM21	hom	FF|FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0189417353093644	0.272640005739068	954	pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH	fungal-type cell wall biogenesis|ascospore formation|invasive growth in response to glucose limitation	molecular_function	integral to membrane
YDL166C	FAP7	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0189011753272169	0.27366836423819	955	Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D	cellular response to oxidative stress|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit export from nucleus	nucleoside-triphosphatase activity	nucleus|preribosome|cytoplasm
YNL097C-B_p	YNL097C-B	hom			0.0188247056222312	0.275685976763969	956	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YFR032C-B_p	YFR032C-B	hom			0.0188212996250611	0.275701274380114	957	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YOR177C	MPC54	hom	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|NUCLEUS|CYTOSKELETON	0.0188207084644658	0.275716358251259	958	Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate	ascospore wall assembly|vesicle docking	structural molecule activity	spindle pole body
YER011W	TIR1	hom			0.0187724540617442	0.276949500743474	959	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking	response to stress	structural constituent of cell wall	fungal-type cell wall
YDR466W	PKH3	hom	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	0.0187464509417165	0.277615566455944	960	Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant	MAPK cascade involved in cell wall biogenesis|protein phosphorylation	protein kinase activity	cellular_component
YOR342C	YOR342C	hom	FT	NUCLEUS	0.0187457835462299	0.277632676024115	961	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YEL015W	EDC3	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS	0.0187451380330761	0.277720878734823	962	Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress	deadenylation-independent decapping of nuclear-transcribed mRNA|cytoplasmic mRNA processing body assembly	molecular_function	cytoplasmic mRNA processing body
YLR104W_p	LCL2	hom	FT	PROTEOLYSIS	0.0187412357247337	0.277749284568625	963	Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)	ER-associated protein catabolic process	molecular_function	cellular_component
YDR381W	YRA1	het	FT	RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|NUCLEUS	0.0187290512222535	0.278061865927267	964	RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member	mRNA export from nucleus|transcription-coupled nucleotide-excision repair	RNA binding	transcription export complex
YKL118W_d	YKL118W	hom	FF		0.0186552558244727	0.280175336455732	965	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2	Unknown	Unknown	Unknown
YLR205C	HMX1	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0186352188289116	0.28069230854371	966	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants	response to oxidative stress|cellular iron ion homeostasis|heme catabolic process	heme oxygenase (decyclizing) activity	endoplasmic reticulum|membrane|nuclear outer membrane
YER081W	SER3	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0186265436599009	0.280988136961572	967	3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication	serine family amino acid biosynthetic process	phosphoglycerate dehydrogenase activity	cytoplasm
YLR035C	MLH2	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.0186226521199299	0.280801600372858	968	Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p	mismatch repair|reciprocal meiotic recombination	molecular_function	nucleus
YDL025C	RTK1	hom	FT	PROTEIN PHOSPHORYLATION	0.0186181298791402	0.280918450770131	969	Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress	biological_process	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YGR159C	NSR1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION	0.018579608911742	0.281915133550135	970	Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis	ribosomal small subunit assembly|rRNA processing	single-stranded DNA binding|RNA binding	mitochondrion|nucleolus|nucleus
YBR157C	ICS2	hom			0.0185673591183948	0.282232583751258	971	Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization	biological_process	molecular_function	cellular_component
YIL120W	QDR1	hom	FT	PLASMA MEMBRANE	0.018548255882944	0.282728122489338	972	Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication	drug transmembrane transport	drug transmembrane transporter activity	integral to membrane|plasma membrane
YNL194C	YNL194C	hom	FT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.0185418031663954	0.282895639329367	973	Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate	ascospore formation	molecular_function	cell cortex|integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YIR016W_p	YIR016W	hom			0.0185389954881141	0.282968549523588	974	Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YIR021W-A_p	YIR021W-A	hom			0.0185162400263429	0.283559936216419	975	Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YIR019C	FLO11	hom	FT	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0184954032712849	0.284102191402075	976	GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain	cell-cell adhesion|biofilm formation|pseudohyphal growth|filamentous growth|flocculation|invasive growth in response to glucose limitation	molecular_function	extracellular region|plasma membrane|cellular bud neck
YKL106W	AAT1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0184245000005476	0.285952629503381	977	Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis	aspartate catabolic process|chronological cell aging|replicative cell aging|asparagine biosynthetic process from oxaloacetate|aspartate biosynthetic process	L-aspartate:2-oxoglutarate aminotransferase activity	mitochondrion
YIL100W_d	YIL100W	hom			0.018419485469756	0.286083806573284	978	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A	Unknown	Unknown	Unknown
YIL029C_p	YIL029C	hom			0.0183904510373656	0.286844128429962	979	Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W	biological_process	molecular_function	integral to membrane
YOR068C	VAM10	hom	FT	MEMBRANE ORGANIZATION	0.0183886831788296	0.286890467173064	980	Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering	vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane
YKR044W	UIP5	hom	FT	ENDOMEMBRANE SYSTEM|NUCLEUS	0.0183762008892327	0.287217794124879	981	Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates	biological_process	molecular_function	nuclear envelope
YPL013C	MRPS16	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.018375168923098	0.287244866964288	982	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YHR187W	IKI1	hom	FT	RNA PROCESSING|NUCLEUS	0.0183583906601423	0.287685273341698	983	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin	tRNA modification	tRNA binding|ATPase activity	Elongator holoenzyme complex|nucleus|cytoplasm
YHR042W	NCP1	het	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE	0.0183534842534474	0.287814145782624	984	NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p	ergosterol biosynthetic process	electron carrier activity	mitochondrial outer membrane|mitochondrion
YEL027W	VMA3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	0.0183329398484963	0.288569950327395	985	Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis	cellular copper ion homeostasis|cellular iron ion homeostasis|endocytosis|vacuole organization|proton transport|vacuolar acidification|protein targeting to vacuole	hydrogen ion transmembrane transporter activity	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YOR197W	MCA1	hom	FT	PROTEOLYSIS|NUCLEUS	0.0183309373314599	0.288406867121616	986	Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization	misfolded or incompletely synthesized protein catabolic process|apoptotic process	cysteine-type peptidase activity	nucleus
YNL297C	MON2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0183306360271039	0.288486691591192	987	Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins	transport|endocytosis|protein targeting to vacuole|Golgi to endosome transport	guanyl-nucleotide exchange factor activity	cytosol|endosome|trans-Golgi network|extrinsic to membrane
YDR277C	MTH1	hom	FT	SIGNALING	0.0183136030244425	0.28929489748022	988	Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation	glucose transport|signal transduction	molecular_function	cellular_component
YJR119C	JHD2	hom	FT	CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEUS	0.018310261875695	0.288951113192842	989	JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation	histone demethylation	histone demethylase activity (H3-K4 specific)	nucleus|cytoplasm
YDR079C-A	TFB5	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME	0.0183099838316609	0.288958436937944	990	Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleus
YDR066C	RTR2	hom	FT	NUCLEUS	0.0182588826858433	0.290666466933506	991	Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YGR163W	GTR2	hom	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION|NUCLEUS|CHROMOSOME	0.0182551428838148	0.290405404871187	992	Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD	microautophagy|positive regulation of transcription from RNA polymerase II promoter	GTP binding	nuclear chromatin|fungal-type vacuole membrane|integral to membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YDR018C_p	YDR018C	hom	FT	LIPID METABOLISM	0.0182275088906898	0.291136365934252	993	Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication	phospholipid biosynthetic process	transferase activity, transferring acyl groups	integral to membrane
YDR247W	VHS1	hom	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	0.0182269389267039	0.291871950244098	994	Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p	protein phosphorylation|G1/S transition of mitotic cell cycle	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YIR001C	SGN1	hom			0.0182258094758717	0.291181358363211	995	Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation	mRNA metabolic process	poly(A) RNA binding	cytoplasm
YGL083W	SCY1	hom	FT	PROTEIN PHOSPHORYLATION	0.0182235290166855	0.291241741428747	996	Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase	biological_process	molecular_function	clathrin-coated vesicle
YHL038C	CBP2	hom	FT	RNA PROCESSING|MITOCHONDRION	0.01821910688801	0.291358856601305	997	Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene	Group I intron splicing	RNA binding	mitochondrion
YKL064W	MNR2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.0182046682799717	0.291741467451154	998	Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations	cellular magnesium ion homeostasis	magnesium ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YIL132C	CSM2	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS	0.0181968604478708	0.291948508913395	999	Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis	meiotic chromosome segregation|recombinational repair|maintenance of rDNA|error-free translesion synthesis	molecular_function	nucleus|Shu complex|cytoplasm
YIL006W	YIA6	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.0181615964683968	0.293100833355995	1000	Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs	transport|mitochondrial pyruvate transport|NAD transmembrane transport	pyruvate secondary active transmembrane transporter activity|transporter activity|NAD transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YPL115C	BEM3	hom	FT	SIGNALING|SITE OF POLARIZED GROWTH	0.0181549803457443	0.29306073386589	1001	Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly	negative regulation of Rho protein signal transduction|establishment of cell polarity	Rho GTPase activator activity|phosphatidylinositol-3-phosphate binding	cell cortex|incipient cellular bud site|mating projection tip|cytoplasm|cellular bud tip
YMR312W	ELP6	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.0181520170391747	0.293355546066866	1002	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	protein urmylation|regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex
YLL004W	ORC3	het	FT	GENE SILENCING|NUCLEUS|CHROMOSOME	0.0181229980470783	0.293912011236841	1003	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing	pre-replicative complex assembly|DNA replication initiation|chromatin silencing at silent mating-type cassette	chromatin binding|DNA replication origin binding	DNA replication preinitiation complex|pre-replicative complex|nuclear origin of replication recognition complex
YOL073C	YOL073C	hom			0.0180895674152134	0.294803609367338	1004	Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2	biological_process	molecular_function	integral to membrane
YIL046W	MET30	het	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0180889896896636	0.294891038350726	1005	F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus	response to cadmium ion|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA-dependent DNA replication initiation|M phase of mitotic cell cycle|response to arsenic-containing substance|G1/S transition of mitotic cell cycle|protein polyubiquitination|regulation of transcription involved in G1 phase of mitotic cell cycle|protein ubiquitination	ubiquitin binding	nuclear SCF ubiquitin ligase complex|SCF ubiquitin ligase complex|nucleus
YBR144C_d	YBR144C	hom			0.0180838681920881	0.294955788745875	1006	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene	Unknown	Unknown	Unknown
YPL015C	HST2	hom	FT	GENE SILENCING|NUCLEUS	0.0180826873091993	0.294987326994515	1007	Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export	negative regulation of chromatin silencing at telomere|chronological cell aging|chromatin silencing at rDNA|negative regulation of mitotic recombination	NAD-dependent histone deacetylase activity	cytoplasm
YDR282C_p	YDR282C	hom			0.0180538012392564	0.295759500550719	1008	Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation	biological_process	molecular_function	cellular_component
YOR376W_d	YOR376W	hom			0.0180368937445361	0.296212093507189	1009	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.	Unknown	Unknown	Unknown
YOR160W	MTR10	het	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION|NUCLEUS	0.0180349319703987	0.296264637780934	1010	Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress	RNA localization|tRNA transport|RNA import into nucleus|protein import into nucleus|mRNA-binding (hnRNP) protein import into nucleus	nuclear localization sequence binding	integral to membrane|nucleus|cytoplasm
YKR041W	YKR041W	hom	FT	NUCLEUS|CYTOSKELETON	0.0180325459000715	0.296400581048186	1011	Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking	biological_process	molecular_function	nucleus|mitotic spindle|cytoplasm
YKR001C	VPS1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION|MITOCHONDRION|CYTOSKELETON	0.0179985314738582	0.297889873930286	1012	Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis	vacuolar transport|peroxisome fission|endocytosis|actin cytoskeleton organization|protein retention in Golgi apparatus|peroxisome organization|lipid tube assembly|protein targeting to vacuole	GTPase activity	mitochondrial outer membrane|fungal-type vacuole membrane|peroxisome|actin cortical patch
YDR313C	PIB1	hom			0.0179757971183402	0.297923481515196	1013	RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain	protein ubiquitination	ubiquitin-protein ligase activity|phosphatidylinositol-3-phosphate binding	fungal-type vacuole membrane|late endosome
YDR217C	RAD9	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0179275255869717	0.299150932051583	1014	DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate	DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of cell cycle|intra-S DNA damage checkpoint|nucleotide-excision repair|DNA damage checkpoint|positive regulation of transcription from RNA polymerase II promoter	double-stranded DNA binding|histone binding	chromatin|nucleus
YNR001C	CIT1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0179257382691178	0.299199120138089	1015	Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication	glutamate biosynthetic process|tricarboxylic acid cycle|acetyl-CoA catabolic process|citrate metabolic process	citrate (Si)-synthase activity	mitochondrion
YER066W_p	RRT13	hom			0.0179235486882624	0.299258160740593	1016	Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription	biological_process	molecular_function	cellular_component
YNL166C	BNI5	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0179235249884982	0.300125030227796	1017	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner	septin ring assembly|cytokinesis	molecular_function	cellular bud neck septin ring|cellular bud neck
YJR045C	SSC1	het	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|NUCLEUS|MITOCHONDRION	0.0179172837572898	0.299427133389363	1018	Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication	protein refolding|positive regulation of endodeoxyribonuclease activity|protein import into mitochondrial matrix|protein unfolding	enzyme regulator activity|ATPase activity	mitochondrial nucleoid|mitochondrion|TRC complex|mitochondrial inner membrane|presequence translocase-associated import motor
YGL198W	YIP4	hom	FT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0179121965699827	0.299997120819374	1019	Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YDR298C	ATP5	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION	0.0178931477624228	0.300078704520132	1020	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, stator stalk|mitochondrial proton-transporting ATP synthase complex
YIR032C	DAL3	hom	FT	PLASMA MEMBRANE	0.0178920643864011	0.300107973292978	1021	Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression	allantoin catabolic process	ureidoglycolate hydrolase activity	membrane
YMR060C	SAM37	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.017890574054815	0.30014823959341	1022	Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability	mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to membrane
YGR246C	BRF1	het	FT	TRANSLATION|NUCLEUS	0.0178904387052369	0.300368182299698	1023	TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB	DNA-dependent transcriptional open complex formation|transposon integration|RNA polymerase III transcriptional preinitiation complex assembly|negative regulation of protein homodimerization activity	TFIIIC-class transcription factor binding|RNA polymerase III core binding|DNA binding|TFIIIB-type transcription factor activity	transcription factor TFIIIB complex
YNL136W	EAF7	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0178427846442532	0.301441339335418	1024	Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A	DNA repair|histone acetylation|regulation of transcription from RNA polymerase II promoter	molecular_function	histone acetyltransferase complex|nucleus|NuA4 histone acetyltransferase complex
YGR031W	IMO32	hom	FT	MITOCHONDRION	0.0178247663686457	0.30192984416945	1025	Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1	biological_process	molecular_function	mitochondrion
YHR058C	MED6	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0178224893186727	0.302280117120308	1026	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress	RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly	core mediator complex
YLR332W	MID2	hom	FT	RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PEROXISOME ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0177814614608217	0.303106063620277	1027	O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p	UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|cell morphogenesis involved in conjugation|response to acid|response to osmotic stress	transmembrane signaling receptor activity	integral to plasma membrane|mating projection tip
YLR443W	ECM7	hom	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS	0.0177765495900386	0.303239668633959	1028	Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency	fungal-type cell wall organization|calcium ion transport	molecular_function	integral to membrane
YOR103C	OST2	het	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0177554122795175	0.303815059065395	1029	Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins	protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex|integral to membrane
YKL175W	ZRT3	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.0177478743362942	0.304020428850501	1030	Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency	cellular zinc ion homeostasis|zinc ion transport	zinc ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YOR100C	CRC1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|MITOCHONDRION	0.0177381632728342	0.304285140692361	1031	Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation	fatty acid metabolic process	carnitine:acyl carnitine antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YLR398C	SKI2	hom	FT	TRANSLATION	0.0177297288729137	0.304515176330943	1032	Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay	RNA helicase activity	Ski complex
YHR032W	ERC1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	0.0177151124759969	0.304914089895053	1033	Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine	S-adenosylmethionine biosynthetic process|transmembrane transport	antiporter activity	integral to membrane
YPL091W	GLR1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|MITOCHONDRION	0.0177134137311054	0.30496047484771	1034	Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress|protein glutathionylation	glutathione-disulfide reductase activity	mitochondrion|nucleus|cytoplasm
YOL163W_p	YOL163W	hom			0.0176801753502163	0.305869004715783	1035	Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family	transmembrane transport	transmembrane transporter activity	integral to membrane|membrane
YIL028W_d	YIL028W	hom			0.0176796159302435	0.305884311099439	1036	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR091C	MSR1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0176664839513252	0.306243763192775	1037	Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6	arginyl-tRNA aminoacylation|mitochondrial arginyl-tRNA aminoacylation|mitochondrial translation	arginine-tRNA ligase activity	mitochondrion
YPR180W	AOS1	het	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0176493647224157	0.308159577378069	1038	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability	protein sumoylation	SUMO activating enzyme activity	nucleus|SUMO activating enzyme complex
YLR422W_p	YLR422W	hom			0.0176491906746141	0.306717546188778	1039	Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein	biological_process	molecular_function	cytoplasm
YBR056W	YBR056W	hom	FT	CARBOHYDRATE METABOLISM	0.0176475484156433	0.307123438789652	1040	Putative glycoside hydrolase of the mitochondrial intermembrane space	biological_process	molecular_function	cytoplasm
YER083C	GET2	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0176206924468044	0.307499369080469	1041	Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division	retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane	protein anchor	integral to membrane|endoplasmic reticulum|GET complex
YDL241W_p	YDL241W	hom			0.0176122712023078	0.3077306504251	1042	Putative protein of unknown function; YDL241W is not an essential gene	biological_process	molecular_function	cellular_component
YLR414C	PUN1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|PLASMA MEMBRANE	0.0175784123801409	0.308661711479354	1043	Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress	fungal-type cell wall organization|protein oligomerization	molecular_function	integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YDL151C_d	BUD30	hom			0.0175647550786928	0.309615558808609	1044	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YLR084C	RAX2	hom	FT	CELL CYCLE|CELL DIVISION|MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0175583927930184	0.309285236846621	1045	N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p	cellular bud site selection	molecular_function	mitochondrion|cellular bud scar|cellular bud neck|membrane
YDR379W	RGA2	hom	FT	SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0175532443958128	0.309354994108569	1046	GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p	budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|actin filament organization|pseudohyphal growth|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth	Rho GTPase activator activity	cellular bud neck split septin rings
YOR055W_d	YOR055W	hom			0.0175528134620433	0.309366873650492	1047	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR097W	VPS15	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS	0.0175352294515084	0.309851868672468	1048	Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery	protein retention in Golgi apparatus|vacuole inheritance|peroxisome degradation|protein phosphorylation|macroautophagy|inositol lipid-mediated signaling|late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding|protein serine/threonine kinase activity	mitochondrion|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|Golgi membrane
YGR136W	LSB1	hom	FT	NUCLEUS	0.0175166098176205	0.310582491999166	1049	Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YDR173C	ARG82	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0175006888326665	0.310806014593009	1050	Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes	protein stabilization|negative regulation of transcription from RNA polymerase II promoter|phosphatidylinositol phosphorylation|regulation of arginine metabolic process|inositol phosphate biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	inositol-1,4,5-trisphosphate 3-kinase activity|inositol-1,4,5-trisphosphate 6-kinase activity|phosphatidylinositol 3-kinase activity|protein binding, bridging|inositol tetrakisphosphate 6-kinase activity|inositol tetrakisphosphate 3-kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity	nucleus
YPL001W	HAT1	hom	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0175003017987051	0.31081671694009	1051	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair	histone acetylation|chromatin silencing at telomere	histone acetyltransferase activity|histone binding	histone acetyltransferase complex|nucleus|cytoplasm
YOR090C	PTC5	hom	FT	MITOCHONDRION	0.0174784567099664	0.311709926055385	1052	Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p	positive regulation of catalytic activity|regulation of catalytic activity|protein dephosphorylation	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|protein serine/threonine phosphatase activity	mitochondrion
YFL001W	DEG1	hom	FT	RNA PROCESSING|NUCLEUS	0.0174767240238383	0.312119332963265	1053	tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability	tRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus|cytoplasm
YLR401C	DUS3	hom	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS|NUCLEUS	0.0174643414587094	0.311812160518063	1054	Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress	tRNA modification	tRNA dihydrouridine synthase activity	nucleus|cytoplasm
YLR141W	RRN5	het	FT	CHROMATIN ORGANIZATION|NUCLEUS	0.0174379908073273	0.312542923696636	1055	Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|chromatin organization	RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity	nucleolus|RNA polymerase I upstream activating factor complex
YDL150W	RPC53	het	FF|FT	NUCLEUS	0.0174333719727929	0.312671130488678	1056	RNA polymerase III subunit C53	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YDR424C	DYN2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON	0.0174003806269007	0.313587890926232	1057	Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex	microtubule-based process|actin filament-based process|nuclear pore complex assembly	molecular_function	cytoplasmic dynein complex|cytoplasmic microtubule|peroxisome|nuclear pore
YGR026W_p	YGR026W	hom	FT	PLASMA MEMBRANE	0.0173936472025278	0.313775215729896	1058	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	integral to membrane
YFL047W	RGD2	hom	FT	SIGNALING|SITE OF POLARIZED GROWTH	0.0173885880062141	0.313916011685513	1059	GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress	small GTPase mediated signal transduction	Rho GTPase activator activity	cellular bud neck|cytoplasm
YOR012W_p	YOR012W	hom			0.0173746544670503	0.314592773575769	1060	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR249W	YEF3	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEOTIDE METABOLISM|RIBOSOME	0.0173420014355286	0.315214454619017	1061	Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication	translational elongation|translational termination	ATPase activity|translation elongation factor activity	cytosolic ribosome|ribosome
YBR155W	CNS1	het			0.0173398684396745	0.315273988979668	1062	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion	protein folding	Hsp70 protein binding|Hsp90 protein binding	cytoplasm
YOR114W_p	YOR114W	hom			0.0173340496726154	0.315436434986698	1063	Putative protein of unknown function; null mutant is viable	biological_process	molecular_function	cellular_component
YDR271C_d	YDR271C	hom			0.0173259946687396	0.315661402038096	1064	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W	Unknown	Unknown	Unknown
YNL267W	PIK1	het	FF|FT	LIPID METABOLISM|SIGNALING|NUCLEUS|GOLGI APPARATUS	0.0173121485399915	0.31684335799592	1065	Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton	phosphatidylinositol phosphorylation	1-phosphatidylinositol 4-kinase activity	trans-Golgi network|nucleus
YKL002W	DID4	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT	0.0173001112252685	0.316601570134769	1066	Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis	protein retention in Golgi apparatus|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	molecular_function	ESCRT III complex|cytoplasm
YLR386W	VAC14	hom	FT	PROTEIN LOCALIZATION|LIPID METABOLISM	0.0172863877289592	0.316769110394062	1067	Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p	phosphatidylinositol biosynthetic process|positive regulation of kinase activity	protein binding, bridging	fungal-type vacuole membrane|PAS complex|extrinsic to vacuolar membrane
YLR459W	GAB1	het	FT	CELL CYCLE|LIPID METABOLISM|CELL DIVISION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0172827214812195	0.316871775031334	1068	GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI	attachment of GPI anchor to protein	GPI-anchor transamidase activity	integral to membrane|GPI-anchor transamidase complex
YGL116W	CDC20	het	FF|FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0172759789977285	0.31706063935713	1069	Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress	spindle checkpoint|activation of mitotic anaphase-promoting complex activity|meiotic anaphase I|positive regulation of protein catabolic process|activation of anaphase-promoting complex activity involved in meiotic cell cycle|positive regulation of mitotic metaphase/anaphase transition|cyclin catabolic process	anaphase-promoting complex binding|ubiquitin-protein ligase activator activity	mitotic checkpoint complex|anaphase-promoting complex
YJL122W	ALB1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0172698851343979	0.317231398597819	1070	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p	ribosomal large subunit biogenesis	molecular_function	ribosome|nucleus|cytoplasm
YJR035W	RAD26	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0172547759583447	0.317655040453074	1071	Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein	transcription-coupled nucleotide-excision repair|nucleotide-excision repair	DNA-dependent ATPase activity	nucleus|cytoplasm
YLR286C	CTS1	hom	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH	0.0172118445982345	0.318860802478347	1072	Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p	cytokinesis, completion of separation|chitin catabolic process	endochitinase activity	nuclear envelope|extracellular region|fungal-type cell wall|endoplasmic reticulum|cellular bud neck
YDL079C	MRK1	hom	FT	PROTEIN PHOSPHORYLATION	0.0171962860733069	0.319298514678341	1073	Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation	regulation of protein catabolic process|protein phosphorylation|response to stress	protein serine/threonine kinase activity	cellular_component
YDL171C	GLT1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0171859382202606	0.319589851158749	1074	NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source	glutamate biosynthetic process|ammonia assimilation cycle	glutamate synthase (NADH) activity	mitochondrion
YJL008C	CCT8	het			0.0171777396446434	0.31982079963503	1075	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	protein folding	unfolded protein binding	chaperonin-containing T-complex|cytoplasm
YFR018C_p	YFR018C	hom	FT	PROTEOLYSIS	0.0171752892266302	0.319889847470535	1076	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL253W	TEX1	hom	FT	RNA LOCALIZATION|NUCLEUS	0.0171641069311229	0.320205065692859	1077	Protein involved in mRNA export, component of the transcription export (TREX) complex	mRNA export from nucleus	molecular_function	transcription export complex
YDR344C_d	YDR344C	hom			0.0171182263975299	0.321500518407037	1078	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML071C	COG8	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0171091691315562	0.321756657177769	1079	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YOR209C	NPT1	hom	FF|FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0171014008456122	0.321976449745708	1080	Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus	chromatin silencing at rDNA|replicative cell aging|nicotinate nucleotide salvage|chromatin silencing at telomere	nicotinate phosphoribosyltransferase activity	nucleus
YMR316W	DIA1	hom			0.0170890883110728	0.32232501595115	1081	Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	pseudohyphal growth|invasive growth in response to glucose limitation	molecular_function	cytoplasm
YKR034W	DAL80	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0170852367040952	0.322434104942794	1082	Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication	nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YHR122W	CIA2	het	FT	CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS	0.0170531956004875	0.323342537590677	1083	Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B	establishment of mitotic sister chromatid cohesion	molecular_function	nucleus|cytoplasm
YIL161W_p	YIL161W	hom			0.0170253274187326	0.324350530579867	1084	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene	biological_process	molecular_function	cytoplasm
YPL261C_d	YPL261C	hom			0.0170183698631742	0.324331809752701	1085	Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W	Unknown	Unknown	Unknown
YER155C	BEM2	hom	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0170068342704984	0.324659927738606	1086	Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence	negative regulation of Rho protein signal transduction|fungal-type cell wall organization|establishment of cell polarity|actin cytoskeleton organization	Rho GTPase activator activity	cell cortex|incipient cellular bud site|mitochondrion|plasma membrane|mating projection tip|cytoplasm|cellular bud tip
YAL025C	MAK16	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0169468464680311	0.326369699245587	1087	Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|preribosome, large subunit precursor
YER136W	GDI1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	0.0169309974056617	0.326822403991533	1088	GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins	vesicle-mediated transport	Rab GDP-dissociation inhibitor activity	cellular_component
YPR020W	ATP20	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.0169091709178732	0.327446511953757	1089	Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex	protein oligomerization|cristae formation|protein complex assembly|ATP synthesis coupled proton transport	structural molecule activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YOR023C	AHC1	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0169041687381256	0.3275896534458	1090	Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex	histone acetylation	histone acetyltransferase activity	Ada2/Gcn5/Ada3 transcription activator complex
YCR086W	CSM1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|KINETOCHORE	0.0169036108737225	0.327822081960346	1091	Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation	meiotic chromosome segregation|rDNA condensation|protein localization to nucleolar rDNA repeats|homologous chromosome segregation	molecular_function	nuclear envelope|nucleolus|monopolin complex
YDL063C	SYO1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0169034167881785	0.327899832975749	1092	Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	ribosomal large subunit biogenesis	molecular_function	nucleus|cytoplasm
YOR036W	PEP12	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0168950804212333	0.327921958453432	1093	Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin	Golgi to vacuole transport|vacuole inheritance	SNAP receptor activity	endosome|Golgi apparatus
YCR064C_d	YCR064C	hom	FF		0.0168888517367359	0.328100344803964	1094	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31	Unknown	Unknown	Unknown
YIL085C	KTR7	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|GOLGI APPARATUS	0.0168714359823488	0.328527329990563	1095	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication	fungal-type cell wall organization|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YDR402C	DIT2	hom	FT	CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS	0.016870432787827	0.328556095378741	1096	N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s	ascospore wall assembly	oxidoreductase activity	cellular_component
YJL198W	PHO90	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.0168657288252658	0.328690997581579	1097	Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication	phosphate ion transport	phosphate ion transmembrane transporter activity	integral to membrane|membrane
YDR405W	MRP20	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0168510937552582	0.329110937762167	1098	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YER163C	GCG1	hom	FT	NUCLEUS	0.0168454872953314	0.329632721187682	1099	Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle	biological_process	molecular_function	nucleus|cytoplasm
YPL237W	SUI3	het	FT	TRANSLATION|RIBOSOME	0.0168369408728446	0.329517372413348	1100	Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding	translational initiation	translation initiation factor activity	multi-eIF complex|ribosome|eukaryotic translation initiation factor 2 complex
YDR216W	ADR1	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING|PEROXISOME ORGANIZATION|NUCLEUS	0.0168315461930757	0.329672379358793	1101	Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization	negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|chromatin organization|regulation of transcription by chromatin organization|positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|peroxisome organization|positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|TFIIB-class transcription factor binding|sequence-specific DNA binding|TFIID-class transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	nucleus
YMR306C-A_d	YMR306C-A	hom			0.0168146543785231	0.330230157366994	1102	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL117W	MLS1	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	0.0167864002169329	0.330971422362144	1103	Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic	glyoxylate cycle	malate synthase activity	peroxisomal matrix|cytoplasm
YBR124W_d	YBR124W	het			0.0167688953799803	0.331476000677503	1104	Putative protein of unknown function	Unknown	Unknown	Unknown
YMR229C	RRP5	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0167610921444584	0.331773192227777	1105	RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	poly(U) RNA binding	small-subunit processome|nucleolus|90S preribosome
YDR414C	ERD1	hom	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0167423311706863	0.332242665217491	1106	Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)	protein retention in ER lumen|protein glycosylation	molecular_function	integral to membrane|membrane
YLR305C	STT4	het	FT	LIPID METABOLISM|SIGNALING|MITOCHONDRION|PLASMA MEMBRANE	0.0167173991355429	0.332963264718869	1107	Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization	phosphatidylinositol phosphorylation	1-phosphatidylinositol 4-kinase activity	mitochondrion|plasma membrane
YOR318C_d	YOR318C	hom			0.0166982120110661	0.33359059372396	1108	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo	Unknown	Unknown	Unknown
YMR066W	SOV1	hom	FT	MITOCHONDRION	0.016696353573268	0.333644404967034	1109	Mitochondrial protein of unknown function	biological_process	molecular_function	mitochondrion
YOR051C	ETT1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEUS	0.0166594275687952	0.33464268667171	1110	Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough	translational termination	molecular_function	nucleus
YER142C	MAG1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0166342679198205	0.335373250564821	1111	3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress	base-excision repair, AP site formation|DNA dealkylation involved in DNA repair	alkylbase DNA N-glycosylase activity	nucleus
YLR458W_d	YLR458W	het			0.016634000040358	0.33538103453418	1112	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis	Unknown	Unknown	Unknown
YAL061W_p	BDH2	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEUS	0.0166314857183728	0.335454100694508	1113	Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3	biological_process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	nucleus|cytoplasm
YKL181W	PRS1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM	0.0166180542291965	0.335844593120738	1114	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YJL069C	UTP18	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0166122039500148	0.336014769140722	1115	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YNL204C	SPS18	hom	FT	SIGNALING|NUCLEOTIDE METABOLISM	0.0166065010926865	0.336180710259134	1116	Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation	sporulation resulting in formation of a cellular spore	molecular_function	cellular_component
YMR296C	LCB1	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.016594455516774	0.336531384323857	1117	Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine	sphingolipid biosynthetic process	serine C-palmitoyltransferase activity	SPOTS complex|serine C-palmitoyltransferase complex
YHR066W	SSF1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0165854570405928	0.337081832239283	1118	Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication	conjugation with cellular fusion|ribosomal large subunit assembly|regulation of cell size	rRNA binding	nucleolus
YOL052C-A	DDR2	hom			0.0165820125750082	0.336893873478085	1119	Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication	response to stress	molecular_function	fungal-type vacuole|cytoplasm
YJL167W	ERG20	het	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM	0.0165808055278919	0.337361657854319	1120	Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis	farnesyl diphosphate biosynthetic process|ergosterol biosynthetic process|isoprenoid biosynthetic process	dimethylallyltranstransferase activity|geranyltranstransferase activity	endoplasmic reticulum|cytoplasm
YJR025C	BNA1	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.0165787687080566	0.337421018399946	1121	3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p	de novo NAD biosynthetic process from tryptophan	3-hydroxyanthranilate 3,4-dioxygenase activity	cytoplasm
YBR148W	YSW1	hom	FT	MEMBRANE ORGANIZATION	0.0165732310258292	0.337149849534385	1122	Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane	ascospore-type prospore membrane assembly	molecular_function	prospore membrane
YGR260W	TNA1	hom	FT	MITOCHONDRION|PLASMA MEMBRANE	0.0165579612577521	0.337595250172839	1123	High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)	nicotinamide mononucleotide transport	nicotinamide mononucleotide transmembrane transporter activity	mitochondrion|integral to membrane|integral to plasma membrane
YDR183W	PLP1	hom	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	0.0165481822334688	0.337952729087381	1124	Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators	protein folding|positive regulation of transcription from RNA polymerase II promoter by pheromones	G-protein beta/gamma-subunit complex binding	cellular_component
YIR024C	YIR024C	hom	FT	MITOCHONDRION	0.0165263329211834	0.338519011934912	1125	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect	biological_process	molecular_function	mitochondrion
YLR419W_p	YLR419W	hom	FT	MITOCHONDRION	0.0165244855150596	0.338573018802607	1126	Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene	biological_process	molecular_function	mitochondrion|cytoplasm
YKL133C_p	YKL133C	hom			0.0164971183346186	0.339373715449868	1127	Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)	biological_process	molecular_function	cellular_component
YJL077C	ICS3	hom			0.0164883633629257	0.339702136597282	1128	Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2	biological_process	molecular_function	cellular_component
YDR057W	YOS9	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX	0.0164547565062185	0.34061551065993	1129	ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family	ER-associated protein catabolic process	oligosaccharide binding	luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum lumen
YLL050C	COF1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	0.0164520586972941	0.340766694379011	1130	Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes	actin filament depolymerization|actin filament severing	actin filament binding	plasma membrane|actin cortical patch
YOR230W	WTM1	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|GENE SILENCING|NUCLEUS	0.0164426830502102	0.34104196210191	1131	Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats	negative regulation of chromatin silencing at silent mating-type cassette|maintenance of protein location in nucleus|negative regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of chromatin silencing at telomere|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter	protein binding|transcription corepressor activity	nucleus
YER169W	RPH1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS	0.0164379396535307	0.34110928585012	1132	JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|histone demethylation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)	nucleus
YLR460C_p	YLR460C	hom	FT	OXIDATION-REDUCTION PROCESS	0.0164265217154839	0.341444799482657	1133	Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine	biological_process	molecular_function	cellular_component
YGL045W	RIM8	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0163948272182796	0.34259323588071	1134	Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family	meiosis|protein processing|invasive growth in response to glucose limitation|ubiquitin-dependent endocytosis	molecular_function	internal side of plasma membrane
YDR092W	UBC13	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|NUCLEUS	0.0163873813717378	0.342596531721959	1135	Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus	postreplication repair|protein monoubiquitination|protein polyubiquitination|free ubiquitin chain polymerization	ubiquitin-protein ligase activity	ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YOR017W	PET127	hom	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.016385140037621	0.342662559625909	1136	Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane	mitochondrial RNA 5'-end processing	molecular_function	mitochondrial envelope|mitochondrion
YHL034C	SBP1	hom	FT	TRANSLATION|NUCLEUS	0.0163678372758297	0.343172558755916	1137	Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11	negative regulation of translation|negative regulation of translation in response to stress	RNA binding|eukaryotic initiation factor 4G binding	nucleolus|cytoplasmic mRNA processing body|cytoplasm
YKL021C	MAK11	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|ENDOMEMBRANE SYSTEM|NUCLEUS	0.0163607707919713	0.343380982806696	1138	Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats	ribosomal large subunit assembly|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	membrane
YPL145C	KES1	hom	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0163568121839206	0.343497776206302	1139	One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication	post-Golgi vesicle-mediated transport|positive regulation of phosphatase activity|maintenance of cell polarity|endocytosis|exocytosis|sterol transport	phosphatidic acid binding|lipid binding|phosphatidylinositol-4,5-bisphosphate binding|oxysterol binding|sterol transporter activity|phosphatidylinositol-4-phosphate binding	Golgi membrane|extrinsic to membrane|cytoplasm
YPL016W	SWI1	het	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|RSC COMPLEX	0.0163418006131269	0.343940902795865	1140	Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter|DNA-dependent DNA replication	RNA polymerase II activating transcription factor binding	SWI/SNF complex|nucleus
YAL064C-A_p	TDA8	hom			0.0162823840475273	0.345698397963684	1141	Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene	biological_process	molecular_function	cellular_component
YDR258C	HSP78	hom	FT	PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0162749617939438	0.345918343622318	1142	Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates	positive regulation of mitochondrial translation in response to stress|protein refolding|protein stabilization|protein import into mitochondrial matrix|mitochondrial genome maintenance|protein unfolding|cellular response to heat	misfolded protein binding|ATPase activity	mitochondrion|mitochondrial matrix
YEL056W	HAT2	hom	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0162663155586251	0.34617467221566	1143	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing	histone acetylation|chromatin assembly or disassembly|chromatin silencing at telomere	histone acetyltransferase activity|histone binding	histone acetyltransferase complex|nucleus|cytoplasm
YBL029C-A	YBL029C-A	hom	FT	PLASMA MEMBRANE	0.0162611872967996	0.346326763152114	1144	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica	biological_process	molecular_function	plasma membrane
YOR284W	HUA2	hom			0.0162185110584428	0.347594079121342	1145	Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly	biological_process	molecular_function	cytoplasm
YNL094W	APP1	hom	FT	CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0162077308235679	0.347914675450591	1146	Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway	actin cytoskeleton organization	molecular_function	actin cytoskeleton|actin cortical patch
YMR292W	GOT1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0161923506348604	0.348660035723795	1147	Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition	ER to Golgi vesicle-mediated transport|Golgi to endosome transport	molecular_function	integral to membrane|endoplasmic reticulum|Golgi apparatus|ER to Golgi transport vesicle|Golgi membrane
YNL189W	SRP1	het	FT	PROTEIN LOCALIZATION|NUCLEUS	0.0161759876645932	0.349075457627781	1148	Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation	protein targeting to membrane|protein import into nucleus	protein transporter activity	integral to membrane|nuclear exosome (RNase complex)|nucleus|cytoplasm
YIL047C	SYG1	hom	FT	SIGNALING|MITOCHONDRION|PLASMA MEMBRANE	0.0161676464674869	0.349108402873724	1149	Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency	signal transduction	molecular_function	mitochondrion|integral to membrane|plasma membrane
YPL067C_p	YPL067C	hom			0.0161457715528295	0.349760941421368	1150	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene	biological_process	molecular_function	cytoplasm
YDR291W	HRQ1	hom	FT	NUCLEUS	0.0160679282823046	0.353673738527989	1151	3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)	biological_process	molecular_function	nucleus
YJL086C_d	YJL086C	het	FF		0.0160480097338548	0.352973975227881	1152	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1	Unknown	Unknown	Unknown
YOR335C	ALA1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0160381307643874	0.352983175205403	1153	Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog	alanyl-tRNA aminoacylation|mitochondrial alanyl-tRNA aminoacylation	alanine-tRNA ligase activity	mitochondrion|cytoplasm
YKR026C	GCN3	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.0160308330113841	0.353202311162019	1154	Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression	regulation of translational initiation	enzyme regulator activity|guanyl-nucleotide exchange factor activity|translation initiation factor activity	eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YOR210W	RPB10	het	FF|FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0160237393464501	0.353415401188982	1155	RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III	transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase II, core complex
YGR227W	DIE2	hom	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0160131257691519	0.353734379245049	1156	Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1	dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity	integral to membrane|endoplasmic reticulum membrane
YHR204W	MNL1	hom	FT	PROTEOLYSIS|ENDOPLASMIC RETICULUM	0.0160121712037352	0.353763076450395	1157	Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation	ER-associated protein catabolic process	carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum lumen
YNL321W	VNX1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0159972594264265	0.354211561783136	1158	Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate	potassium ion transport|sodium ion transport|hydrogen transport	potassium:hydrogen antiporter activity|sodium:hydrogen antiporter activity|calcium:hydrogen antiporter activity	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum membrane|fungal-type vacuole
YPL003W	ULA1	hom			0.0159929953586371	0.354339873499994	1159	Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation	protein neddylation	NEDD8 activating enzyme activity	cellular_component
YNL219C	ALG9	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0159925073515089	0.354354560182875	1160	Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation	dolichol-linked oligosaccharide biosynthetic process|protein glycosylation	mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YPL142C_d	YPL142C	het			0.015992339918917	0.355078116482139	1161	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit	Unknown	Unknown	Unknown
YNL016W	PUB1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEUS	0.0159713642791019	0.355493892362585	1162	Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|stress granule assembly|regulation of mRNA stability	mRNA binding|poly(U) RNA binding	nucleus|cytoplasmic stress granule|cytoplasm
YOL122C	SMF1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0159641974408307	0.355207210991837	1163	Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins	copper ion transport|cellular copper ion homeostasis|manganese ion transport|cadmium ion transport|cellular manganese ion homeostasis|cellular cadmium ion homeostasis|iron ion transport	solute:hydrogen symporter activity|inorganic cation transmembrane transporter activity	integral to membrane|plasma membrane
YDR179W-A_p	YDR179W-A	hom			0.0159475823829661	0.3557082330285	1164	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGL224C	SDT1	hom			0.0159424654660485	0.355862621799344	1165	Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives	pyrimidine nucleobase metabolic process	nucleotidase activity	cellular_component
YMR120C	ADE17	hom	FT	NUCLEOTIDE METABOLISM	0.0159385346377255	0.355981252321247	1166	Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity	cytosol|plasma membrane
YDL175C	AIR2	hom	FT	RNA PROCESSING|NUCLEUS	0.0159350147386181	0.356087502346106	1167	RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication	nuclear polyadenylation-dependent CUT catabolic process|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|tRNA modification	polynucleotide adenylyltransferase activity|RNA binding|protein binding, bridging	nucleolus|TRAMP complex
YDR453C	TSA2	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	0.0159294689856327	0.356254944391336	1168	Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress|cell redox homeostasis	peroxiredoxin activity|thioredoxin peroxidase activity	cytoplasm
YLR076C_d	YLR076C	het			0.0159234987764141	0.357801272306582	1169	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10	Unknown	Unknown	Unknown
YDL007W	RPT2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS	0.0159031347998404	0.357050725269276	1170	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle	positive regulation of protein catabolic process|proteasome regulatory particle assembly|peptide catabolic process|ubiquitin-dependent protein catabolic process	ATPase activity	proteasome regulatory particle, base subcomplex|nucleus
YGL158W	RCK1	hom	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	0.0158858453519631	0.357573795373209	1171	Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication	protein phosphorylation|regulation of meiosis	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YNL082W	PMS1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.0158798582083604	0.357755041073771	1172	ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL	mismatch repair|meiotic mismatch repair	double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding	nucleus|MutLalpha complex|cytoplasm
YDL156W	CMR1	hom	FT	NUCLEUS|CHROMOSOME	0.0158771392910832	0.357837368529368	1173	DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS	biological_process	DNA binding	nuclear chromatin|nucleus|cytoplasm
YOL045W	PSK2	hom	FT	SIGNALING|TRANSLATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.015868889178877	0.358230629159515	1174	PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication	regulation of (1->6)-beta-D-glucan biosynthetic process|negative regulation of glycogen biosynthetic process|protein phosphorylation	protein serine/threonine kinase activity	mitochondrion|cytoplasm
YLR030W_p	YLR030W	hom			0.0158644635202785	0.358221341808651	1175	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR001C	NTH2	hom	FF|FT	CARBOHYDRATE METABOLISM|MITOCHONDRION	0.0158378791640366	0.359027473758744	1176	Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication	trehalose catabolic process	alpha,alpha-trehalase activity	mitochondrion|cytoplasm
YLR404W	FLD1	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0157962900859333	0.360290886307919	1177	Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy	lipid particle organization	molecular_function	integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum
YBL091C-A	SCS22	hom	FT	LIPID METABOLISM	0.0157794552721451	0.360803094357214	1178	Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication	phospholipid biosynthetic process|chromatin silencing at telomere	molecular_function	cellular_component
YJL014W	CCT3	het	FF		0.0157519740101118	0.361926698803518	1179	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	protein folding	unfolded protein binding	chaperonin-containing T-complex
YLR172C	DPH5	hom			0.0157097847656723	0.363142449529664	1180	Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	diphthine synthase activity	cytoplasm
YDL165W	CDC36	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|NUCLEUS	0.0156990510117902	0.363255730209551	1181	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor	response to pheromone involved in conjugation with cellular fusion|regulation of cell cycle|deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination	ubiquitin-protein ligase activity	CCR4-NOT core complex|nucleus|cytoplasm
YFL010C	WWM1	hom	FT	NUCLEUS|MITOCHONDRION	0.0156923539033625	0.364895142836598	1182	WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1	biological_process	molecular_function	mitochondrion|nucleus|cytoplasm
YDL081C	RPP1A	hom	FT	TRANSLATION|RIBOSOME	0.0156158796185926	0.365803719126233	1183	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component	cytoplasmic translation|translational elongation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR202C	PCT1	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS	0.0156122987516058	0.366128174143025	1184	Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity	phosphatidylcholine biosynthetic process|CDP-choline pathway	choline-phosphate cytidylyltransferase activity	nuclear envelope|Golgi apparatus|nucleus
YBR264C	YPT10	hom	FT	PROTEIN LOCALIZATION|SIGNALING|PLASMA MEMBRANE	0.0155981311998778	0.366348889036198	1185	Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles	Golgi organization	GTPase activity|guanyl nucleotide binding	cytoplasm
YNL055C	POR1	hom	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.0155869238320372	0.366693401314633	1186	Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication	DNA transport|mitochondrion organization|apoptotic process|ion transport|cell redox homeostasis	voltage-gated anion channel activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YHL030W	ECM29	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEUS	0.0155582820878456	0.367574759857767	1187	Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress	proteasome assembly	protein complex scaffold	proteasome complex|nucleus|cytoplasm
YGR148C	RPL24B	hom	FT	TRANSLATION|RIBOSOME	0.0155397644700061	0.368145282063958	1188	Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YPR115W	RGC1	hom	FT	CELL CYCLE	0.0155301222109497	0.368442575194544	1189	Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication	positive regulation of glycerol transport	molecular_function	cytoplasm
YMR019W	STB4	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0155183984641142	0.368804246523593	1190	Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;	biological_process	sequence-specific DNA binding|DNA binding	nucleus
YBR196C	PGI1	het	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.0155155024341174	0.369107874861112	1191	Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation	gluconeogenesis|pentose-phosphate shunt|glycolysis	glucose-6-phosphate isomerase activity	cytosol|mitochondrion|plasma membrane
YGL241W	KAP114	hom	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS	0.0154883838589313	0.369731186699974	1192	Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress	protein import into nucleus|transcription factor import into nucleus	protein transporter activity	integral to membrane|nucleus|cytoplasm
YBR216C	YBP1	hom	FT	RESPONSE TO OXIDATIVE STRESS	0.015482938939247	0.369970866330303	1193	Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication	cellular response to oxidative stress	molecular_function	cytoplasm
YER010C	YER010C	hom			0.0154680511576684	0.370359942464138	1194	Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction	biological_process	molecular_function	cellular_component
YDR492W	IZH1	hom	FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0154658336444167	0.370428555581734	1195	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc	response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process	metal ion binding	integral to membrane|endoplasmic reticulum|membrane
YAL046C	AIM1	hom			0.0154446807175468	0.371154789185185	1196	Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YOL159C	YOL159C	hom			0.0154400777810097	0.371226057786889	1197	Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA	biological_process	molecular_function	cellular_component
YHL008C_p	YHL008C	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.0154021214267315	0.372617215287191	1198	Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	chloride transport|monocarboxylic acid transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|fungal-type vacuole
YNL119W	NCS2	hom	FT	RNA PROCESSING	0.0153956714099382	0.373245835136752	1199	Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	tRNA wobble position uridine thiolation|pseudohyphal growth|protein urmylation|invasive growth in response to glucose limitation	molecular_function	cytosol|cytoplasm
YKL197C	PEX1	hom	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION	0.0153899292112988	0.372781905996752	1200	AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis	protein import into peroxisome matrix, receptor recycling	ATPase activity|protein heterodimerization activity	peroxisomal membrane|peroxisome
YBR069C	TAT1	hom	FF|FT	PLASMA MEMBRANE	0.0153867504043939	0.373951869674264	1201	Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress	amino acid transport|tyrosine transport|tryptophan transport|transmembrane transport	amino acid transmembrane transporter activity|low-affinity tryptophan transmembrane transporter activity	integral to membrane|plasma membrane
YGL238W	CSE1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|ENDOMEMBRANE SYSTEM|NUCLEUS	0.0153640077120281	0.373872842064833	1202	Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation	protein export from nucleus	importin-alpha export receptor activity	nuclear envelope|integral to membrane
YCR052W	RSC6	het	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS|RSC COMPLEX	0.0153624793669594	0.373991712365342	1203	Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p	nucleosome positioning|ATP-dependent chromatin remodeling|G2/M transition of mitotic cell cycle|G1 phase of mitotic cell cycle|nucleosome disassembly|positive regulation of transcription elongation from RNA polymerase II promoter	DNA translocase activity	RSC complex
YCL075W	YCL075W	hom	FT	NUCLEUS	0.0153612635448592	0.373673062807417	1204	Pseudogene: encodes fragment of Ty Pol protein	transposition, RNA-mediated	ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity	retrotransposon nucleocapsid
YBR133C	HSL7	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH	0.015335024711436	0.374489928533556	1205	Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress	G2/M transition of mitotic cell cycle|regulation of cell cycle	protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity	cellular bud neck
YDL061C	RPS29B	hom	FT	TRANSLATION|RIBOSOME	0.0153223458357927	0.374885041697682	1206	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YIR003W	AIM21	hom	FT	SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0152687947288759	0.376556699977286	1207	Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton	mitochondrion migration along actin filament	molecular_function	ribosome|mating projection tip|actin cytoskeleton
YKL168C	KKQ8	hom	FT	PROTEIN PHOSPHORYLATION	0.0152537656961726	0.377525108404737	1208	Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication	biological_process	protein kinase activity	cytoplasm
YHR048W_p	YHK8	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.0152532278241556	0.377043499534933	1209	Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles	drug transport	molecular_function	integral to membrane
YGR252W	GCN5	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME|HISTONE ACETYLTRANSFERASE	0.015244276098118	0.377323608496025	1210	Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation	histone acetylation|regulation of transcription by chromatin organization|chromatin modification|positive regulation of transcription elongation from RNA polymerase II promoter	histone acetyl-lysine binding|transcription coactivator activity|histone acetyltransferase activity|H3 histone acetyltransferase activity	SLIK (SAGA-like) complex|chromosome, centromeric region|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YER159C	BUR6	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0152202952743153	0.378074625422183	1211	Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity|transcription corepressor activity	nucleus|negative cofactor 2 complex
YGL180W	ATG1	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.0152144423521004	0.378258063324403	1212	Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p	piecemeal microautophagy of nucleus|mitochondrion degradation|protein phosphorylation|CVT pathway|autophagic vacuole assembly	protein serine/threonine kinase activity|protein kinase activity	cytosol|pre-autophagosomal structure|Atg1p signaling complex
YKR009C	FOX2	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0152046935443324	0.378634822146318	1213	Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities	fatty acid beta-oxidation	enoyl-CoA hydratase activity|3-hydroxyacyl-CoA dehydrogenase activity	peroxisome
YGR200C	ELP2	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.0151887976261247	0.379062446831217	1214	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin	regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YIL140W	AXL2	hom	FT	CELL CYCLE|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON	0.0151756049893911	0.379476662250832	1215	Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate	axial cellular bud site selection|cellular bud site selection	molecular_function	integral to plasma membrane|cellular bud neck|septin ring
YGR107W_d	YGR107W	hom			0.0151614615344528	0.379921039879818	1216	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR162W-A	YSY6	hom	FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0151499441424262	0.380283144519246	1217	Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion	protein secretion	molecular_function	endoplasmic reticulum
YCL063W	VAC17	hom			0.0151113363907738	0.381498510445139	1218	Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p	vacuole inheritance	protein anchor	fungal-type vacuole membrane
YPL030W	TRM44	hom	FT	RNA PROCESSING	0.0151100082643742	0.381611357494805	1219	tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene	tRNA methylation	tRNA (uracil) methyltransferase activity	cytoplasm
YEL036C	ANP1	hom	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0150906938798065	0.382149309828278	1220	Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity|mannosyltransferase activity	alpha-1,6-mannosyltransferase complex|Golgi cis cisterna
YFR026C	ULI1	hom	FT	SIGNALING	0.0150867718082497	0.382273038424443	1221	Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response	endoplasmic reticulum unfolded protein response	molecular_function	cellular_component
YBR261C	TAE1	hom	FT	TRANSLATION	0.0150683031760986	0.382855993617329	1222	AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm	cytoplasmic translation|N-terminal peptidyl-proline dimethylation	N-terminal protein N-methyltransferase activity	cytosol|cytoplasm
YOL147C	PEX11	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|PEROXISOME ORGANIZATION|ENDOPLASMIC RETICULUM	0.0150217225032222	0.384683377897616	1223	Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p	peroxisome fission|fatty acid oxidation	molecular_function	endoplasmic reticulum|peroxisomal membrane
YNL161W	CBK1	het	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH	0.0150115525538476	0.38472159390019	1224	Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress	regulation of fungal-type cell wall organization|establishment or maintenance of cell polarity|protein phosphorylation|establishment or maintenance of actin cytoskeleton polarity|budding cell apical bud growth|Unknown	protein serine/threonine kinase activity	incipient cellular bud site|cellular bud|cellular bud neck|cellular bud tip|cytoplasm|cell cortex|nucleus|mating projection tip
YKL056C	TMA19	hom	FT	TRANSLATION|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION|CYTOSKELETON	0.0150039781529158	0.384890635242599	1225	Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress	cytoplasmic translation|cellular response to oxidative stress	molecular_function	cytosol|mitochondrion|ribosome|cytoplasm
YPL203W	TPK2	hom	FT	SIGNALING|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0150012732947669	0.384976336162391	1226	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase	protein phosphorylation|Ras protein signal transduction|invasive growth in response to glucose limitation	cAMP-dependent protein kinase activity|protein kinase activity	nucleus|cAMP-dependent protein kinase complex
YBR208C	DUR1,2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0149992502605091	0.385040441746606	1227	Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress	allantoin catabolic process|urea catabolic process	urea carboxylase activity|allophanate hydrolase activity	cytoplasm
YLL024C	SSA2	hom	FT	PROTEIN LOCALIZATION|MITOCHONDRION	0.0149838077877438	0.385600847489424	1228	ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity|ATP binding	cytosol|fungal-type vacuole membrane|mitochondrion|fungal-type cell wall|plasma membrane|polysome|chaperonin-containing T-complex|cytoplasm
YGR184C	UBR1	hom	FT	PROTEOLYSIS	0.0149743179768028	0.386611299372409	1229	E3 ubiquitin ligase (N-recognin); forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; plays a major role in targeting cytosolic misfolded proteins for degradation; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)	regulation of dipeptide transport|ubiquitin-dependent protein catabolic process via the N-end rule pathway|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	ubiquitin-protein ligase activity	proteasome regulatory particle, base subcomplex|cytoplasm
YHR207C	SET5	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.0149717641645441	0.385912062931971	1230	Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus	histone lysine methylation	S-adenosylmethionine-dependent methyltransferase activity	nuclear chromatin|nucleus|cytoplasm
YDR332W	IRC3	hom	FT	MITOCHONDRION	0.0149655473873153	0.386109372219652	1231	Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	ATP-dependent RNA helicase activity	mitochondrion
YIL038C	NOT3	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.0149458600179817	0.386734619890633	1232	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation	regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of transcription elongation from RNA polymerase II promoter|protein ubiquitination	ubiquitin-protein ligase activity	CCR4-NOT core complex|cytoplasm
YDR081C	PDC2	het	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.0149398742510311	0.386924843151233	1233	Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions	positive regulation of thiamine biosynthetic process|Unknown|positive regulation of transcription from RNA polymerase II promoter	transcription regulatory region sequence-specific DNA binding	nucleus
YPL200W	CSM4	hom	FT	CELL CYCLE|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|CHROMOSOME	0.014923725767331	0.387438314568176	1234	Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements	meiotic telomere clustering|meiotic chromosome segregation|synapsis|regulation of reciprocal meiotic recombination	molecular_function	nuclear chromosome, telomeric region|endoplasmic reticulum membrane
YBR151W	APD1	hom	FT	NUCLEUS	0.0149205459142853	0.387539472892471	1235	Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YDL172C_d	YDL172C	hom			0.0149198486338823	0.387561657112008	1236	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER177W	BMH1	hom	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.0149090059966335	0.387906718964402	1237	14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	glycogen metabolic process|pseudohyphal growth|signal transduction involved in filamentous growth|ascospore formation|fungal-type cell wall chitin biosynthetic process|Ras protein signal transduction|DNA damage checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	DNA replication origin binding|phosphoserine binding	plasma membrane|nucleus
YJL117W	PHO86	hom	FT	VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOPLASMIC RETICULUM	0.0148392994497834	0.390129562841757	1238	Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress	protein folding|ER to Golgi vesicle-mediated transport|regulation of phosphate transport	unfolded protein binding	endoplasmic reticulum
YOL069W	NUF2	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.0148233224337623	0.391064357254207	1239	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering	microtubule nucleation|chromosome segregation	structural constituent of cytoskeleton	spindle microtubule|Ndc80 complex|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region|spindle pole body
YMR043W	MCM1	het	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|NUCLEUS|CHROMOSOME	0.0148195759262041	0.39075992036964	1240	Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes	regulation of mating type switching|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|DNA replication initiation|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of mating-type specific transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	DNA replication origin binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II repressing transcription factor binding	nuclear chromatin
YER019W	ISC1	hom	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0148194931166426	0.390833221249864	1241	Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance	response to salt stress|ceramide biosynthetic process|sphingolipid catabolic process	inositol phosphosphingolipid phospholipase activity	mitochondrion|endoplasmic reticulum|integral to mitochondrial outer membrane
YDL076C	RXT3	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.0148167263089267	0.390851044332216	1242	Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase I promoter	molecular_function	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YLL039C	UBI4	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.01480663252734	0.391173923160374	1243	Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress	protein deubiquitination|ascospore formation|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress	ATP-dependent protein binding|protein tag	cytoplasm
YJR144W	MGM101	hom	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|MITOCHONDRION|CHROMOSOME	0.0147594507357997	0.392897099495431	1244	Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage	DNA repair|recombinational repair|DNA strand renaturation	molecular_function	mitochondrial nucleoid|mitochondrion
YJL154C	VPS35	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM	0.0147502262830679	0.392981218354538	1245	Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YBR128C	ATG14	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	0.0147421563805003	0.393240196555156	1246	Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor	piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|macroautophagy|CVT pathway	1-phosphatidylinositol-3-kinase activity	phosphatidylinositol 3-kinase complex I|fungal-type vacuole membrane|pre-autophagosomal structure|extrinsic to membrane
YDL130W	RPP1B	hom	FT	TRANSLATION|RIBOSOME	0.0147287868781455	0.394092969841942	1247	Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component	cytoplasmic translation|translational elongation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDL068W_d	YDL068W	hom			0.014727925966099	0.393697128775302	1248	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR186W_p	YOR186W	hom			0.0147176722842575	0.394026568997606	1249	Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YGR197C	SNG1	hom	FT	PLASMA MEMBRANE	0.0147059160917531	0.394404488498524	1250	Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance	nucleobase-containing compound transport	molecular_function	integral to membrane|plasma membrane
YMR061W	RNA14	het	FT	RNA PROCESSING|NUCLEUS|MITOCHONDRION	0.0147016847152222	0.394540565734737	1251	Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping	mRNA cleavage|mRNA polyadenylation	RNA binding|protein heterodimerization activity	mRNA cleavage factor complex|mitochondrion|nucleus
YPR089W_p	YPR089W	hom	FT	GOLGI APPARATUS	0.01468249067182	0.395158185150308	1252	Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p	biological_process	molecular_function	cellular_component
YJL047C-A_p	YJL047C-A	hom			0.0146713459637483	0.395517063711322	1253	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR478W	SNM1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0146677334399444	0.395633435358912	1254	Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP	mRNA cleavage|rRNA processing	ribonuclease MRP activity|RNA binding	ribonuclease MRP complex
YMR175W-A_p	YMR175W-A	hom			0.0146357429364403	0.396664860067201	1255	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YFR054C_d	YFR054C	hom			0.014632826580273	0.396758968634776	1256	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR199W	CLN1	hom	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.014630079483265	0.396918033012146	1257	G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)	regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase regulator activity	nucleus|cytoplasm
YNL287W	SEC21	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0146151416191866	0.397329937094483	1258	Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport	molecular_function	endosome|COPI vesicle coat
YPR005C	HAL1	hom	FT	TRANSCRIPTION FROM RNA POL II	0.0146125645604159	0.397413180145192	1259	Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p	response to salt stress|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YOR179C	SYC1	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.0146097124774437	0.397505319162923	1260	Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication	termination of RNA polymerase II transcription, exosome-dependent|termination of RNA polymerase II transcription, poly(A)-coupled	RNA binding	mRNA cleavage and polyadenylation specificity factor complex|nucleus
YIL087C	AIM19	hom	FT	MITOCHONDRION	0.0145870209583384	0.398238846971776	1261	Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth	biological_process	molecular_function	mitochondrion
YLR358C_p	YLR358C	hom			0.0145607624631738	0.399370044981368	1262	Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W	biological_process	molecular_function	cellular_component
YBR158W	AMN1	hom	FT	CELL CYCLE|CELL DIVISION|NUCLEUS	0.0145589945843538	0.399145953904169	1263	Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)	mitotic cell cycle checkpoint|negative regulation of exit from mitosis	protein binding	nucleus|cellular bud|cytoplasm
YLR039C	RIC1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS	0.0145569016969531	0.399213742531351	1264	Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes	intracellular protein transport|retrograde transport, endosome to Golgi	guanyl-nucleotide exchange factor activity	nucleus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YJL115W	ASF1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS	0.0145503362357775	0.400623906631261	1265	Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition	DNA replication-independent nucleosome assembly|histone acetylation|nucleosome disassembly|histone exchange|positive regulation of histone acetylation|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere|DNA replication-dependent nucleosome assembly|regulation of transcription from RNA polymerase II promoter in response to stress	histone binding	chromatin assembly complex
YBR295W	PCA1	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0145429323714185	0.399947633596241	1266	Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function	cadmium ion transport|cellular iron ion homeostasis|cellular metal ion homeostasis|transmembrane transport	copper-transporting ATPase activity|cadmium-exporting ATPase activity|copper ion binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	integral to membrane|plasma membrane
YBR180W	DTR1	hom	FT	CELL WALL ORG/BIOGENESIS	0.0145366300368676	0.399870699957955	1267	Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation	ascospore wall assembly|amine transport|transmembrane transport	amine transmembrane transporter activity	integral to membrane|prospore membrane
YOL153C	YOL153C	hom			0.014530070730646	0.400083410907585	1268	Hypothetical protein	biological_process	molecular_function	cellular_component
YJL207C	LAA1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0145194361942239	0.400990936707808	1269	AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene	protein localization|retrograde transport, endosome to Golgi	molecular_function	AP-1 adaptor complex|ribosome|clathrin-coated vesicle
YNL257C	SIP3	hom	FT	TRANSCRIPTION FROM RNA POL II	0.0145146043284228	0.400585238107037	1270	Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	transcription cofactor activity	integral to membrane
YMR075W	RCO1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.0145078437322322	0.400804712979791	1271	Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p	regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|transcription elongation from RNA polymerase II promoter|histone deacetylation	molecular_function	Rpd3S complex|histone deacetylase complex|nucleus|Rpd3L complex
YOR044W	IRC23	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0144921566639015	0.401314253414777	1272	Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication	biological_process	molecular_function	endoplasmic reticulum
YER042W	MXR1	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0144918265775399	0.401676219824713	1273	Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan	cellular response to oxidative stress	peptide-methionine-(S)-S-oxide reductase activity	nucleus|cytoplasm
YIR018C-A_p	YIR018C-A	hom			0.0144763905613424	0.401826752466305	1274	Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YJL048C	UBX6	hom	FT	PROTEOLYSIS|NUCLEUS	0.0144543783823921	0.402542945118216	1275	UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication	sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process	molecular_function	nucleus
YDR321W	ASP1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0144505631467636	0.402667156122367	1276	Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively	asparagine catabolic process	asparaginase activity	intracellular
YGL221C	NIF3	hom	FT	MITOCHONDRION	0.0144427296194885	0.402922260909421	1277	Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YOR345C_d	YOR345C	hom			0.0144400543869708	0.403009404066678	1278	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	Unknown	Unknown	Unknown
YOR144C	ELG1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0144113689872445	0.403944512957294	1279	Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication	negative regulation of DNA recombination|negative regulation of transposition, RNA-mediated|telomere maintenance|double-strand break repair via homologous recombination|DNA-dependent DNA replication|mitotic sister chromatid cohesion	chromatin binding	Elg1 RFC-like complex|mitochondrion|nucleus|cytoplasm
YDR034C	LYS14	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.014402354954762	0.404308709229676	1280	Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YGL041C_d	YGL041C	hom			0.0143895384048181	0.405288237186376	1281	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL020C	SPT23	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0143893275849768	0.404874157974195	1282	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting	cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	DNA binding	integral to endoplasmic reticulum membrane|nucleus
YMR264W	CUE1	hom	FF|FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|UBIQUITIN LIGASE COMPLEX	0.0143808441845843	0.404941008475951	1283	Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication	ER-associated protein catabolic process|establishment of protein localization to endoplasmic reticulum membrane	ubiquitin-protein ligase activator activity	Doa10p ubiquitin ligase complex|mitochondrion|integral to endoplasmic reticulum membrane
YDR463W	STP1	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS|PLASMA MEMBRANE	0.0143692700495993	0.405669575319506	1284	Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication	positive regulation of transcription, DNA-dependent|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	plasma membrane|nucleus|cytoplasm
YLR375W	STP3	hom	FT	NUCLEUS	0.0143262245889093	0.406727751052608	1285	Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids	biological_process	sequence-specific DNA binding	nucleus
YER005W	YND1	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|GOLGI APPARATUS	0.0143245193677263	0.40678360865421	1286	Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity	protein glycosylation	nucleoside-triphosphatase activity|nucleoside-diphosphatase activity	COPI-coated vesicle|Golgi apparatus|membrane|Golgi membrane
YNL329C	PEX6	hom	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION	0.0142959011315202	0.407721733195398	1287	AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol	protein import into peroxisome matrix, receptor recycling|replicative cell aging	ATPase activity|protein heterodimerization activity	cytosol|peroxisome
YDL026W_d	YDL026W	hom			0.0142676493732339	0.40885879259922	1288	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL167C	NRP1	hom			0.0142638628011047	0.408773498325774	1289	Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	cytoplasmic stress granule|cytoplasm
YMR100W	MUB1	hom	FT	CELL DIVISION	0.0142531116902515	0.409476250464809	1290	MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene	regulation of cell budding|protein monoubiquitination	molecular_function	cellular_component
YER032W	FIR1	hom	FT	RNA PROCESSING|SITE OF POLARIZED GROWTH	0.014247456035115	0.409312729640027	1291	Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate	mRNA polyadenylation|RNA polyadenylation	molecular_function	cellular bud neck
YDL003W	MCD1	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0142417039317901	0.40950188066114	1292	Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase	double-strand break repair|apoptotic process|response to DNA damage stimulus|mitotic chromosome condensation|establishment of mitotic sister chromatid cohesion	chromatin binding	condensed nuclear chromosome|mitochondrion|nucleus|nuclear mitotic cohesin complex
YMR255W	GFD1	hom	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0142297069558892	0.409896554012693	1293	Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress	mRNA export from nucleus	molecular_function	integral to membrane|nuclear pore|cytoplasm
YGR002C	SWC4	het	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|HISTONE ACETYLTRANSFERASE	0.0141937441895716	0.411081001250033	1294	Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex	DNA repair|histone acetylation|chromosome organization|chromatin modification|chromatin remodeling|histone exchange|establishment of mitotic sister chromatid cohesion	DNA binding	Swr1 complex|histone acetyltransferase complex|nucleus|NuA4 histone acetyltransferase complex
YER099C	PRS2	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM	0.01419058664029	0.411743630627883	1295	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YNL009W	IDP3	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0141891497974759	0.411441779224394	1296	Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication	NADPH regeneration|fatty acid beta-oxidation|isocitrate metabolic process	isocitrate dehydrogenase (NADP+) activity	mitochondrion|peroxisome|cytoplasm
YLR183C	TOS4	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0141514259411878	0.412477366778617	1297	Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication	response to DNA damage stimulus	chromatin binding	nuclear chromatin|Rpd3L-Expanded complex|mitochondrion|nucleus|cytoplasm
YPL182C_d	YPL182C	hom			0.0141431311320449	0.412751397734508	1298	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W	Unknown	Unknown	Unknown
YLL001W	DNM1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION|MITOCHONDRION	0.0141403408849452	0.412843601794206	1299	Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance	mitochondrion inheritance|peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization|mitochondrion organization|protein homooligomerization	protein homodimerization activity|GTPase activity|identical protein binding	mitochondrial outer membrane|mitochondrion|peroxisome
YGL071W	AFT1	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION|NUCLEUS	0.0141061106019847	0.414184648051869	1300	Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|meiotic chromosome segregation|positive regulation of iron ion transport|establishment of mitotic sister chromatid cohesion|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus|cytoplasm
YMR052C-A_d	YMR052C-A	hom			0.0141003927507766	0.414165029860147	1301	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR208W	SER2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0140984820248228	0.414506827527544	1302	Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source	L-serine biosynthetic process	phosphoserine phosphatase activity	nucleus|cytoplasm
YMR145C	NDE1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0140715426323304	0.415120904683941	1303	Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain	glucose catabolic process to ethanol|NADH oxidation|chronological cell aging	NADH dehydrogenase activity	mitochondrion
YER176W	ECM32	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	0.0140538595971053	0.415707430379912	1304	DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes	regulation of translational termination	RNA helicase activity|DNA helicase activity	polysome
YPR063C_p	YPR063C	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0140491999211976	0.415931592766699	1305	ER-localized protein of unknown function	biological_process	molecular_function	endoplasmic reticulum
YGL200C	EMP24	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0140461635134254	0.416310624989987	1306	Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles	protein retention in ER lumen|vesicle organization|ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum|ER to Golgi transport vesicle
YOL111C	MDY2	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|NUCLEUS	0.0140054602775936	0.417315279149785	1307	Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes	protein insertion into ER membrane|cell morphogenesis involved in conjugation with cellular fusion|posttranslational protein targeting to membrane	molecular_function	ribosome|TRC complex|nucleus|cytoplasm
YGL113W	SLD3	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0139759867591293	0.418296196093322	1308	Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress	DNA unwinding involved in replication|double-strand break repair via break-induced replication|DNA replication initiation	chromatin binding	nuclear chromatin|DNA replication preinitiation complex
YDR127W	ARO1	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0139678792937171	0.419887549974227	1309	Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids	aromatic amino acid family biosynthetic process	shikimate kinase activity|shikimate 3-dehydrogenase (NADP+) activity|3-phosphoshikimate 1-carboxyvinyltransferase activity|3-dehydroquinate dehydratase activity|3-dehydroquinate synthase activity	cytoplasm
YER016W	BIM1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.0139525119014103	0.419078439703701	1310	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally	nuclear migration along microtubule|microtubule nucleation|microtubule depolymerization|negative regulation of microtubule depolymerization|positive regulation of microtubule polymerization|mitotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint	microtubule plus-end binding|protein homodimerization activity|structural constituent of cytoskeleton	spindle midzone|microtubule plus end|cytoplasmic microtubule|spindle pole body|kinetochore|spindle pole|spindle
YDR423C	CAD1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0139502517722737	0.419153798478475	1311	AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication	cellular response to cadmium ion|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YDR506C	GMC1	hom	FT	CELL CYCLE|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS	0.0139454136585184	0.419315140961596	1312	Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein	meiosis|synaptonemal complex organization	molecular_function	cellular_component
YDL035C	GPR1	hom	FT	SIGNALING|PLASMA MEMBRANE	0.0139400167914239	0.419495159940518	1313	Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis	replicative cell aging|G-protein coupled receptor signaling pathway|sucrose mediated signaling|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|invasive growth in response to glucose limitation|detection of glucose|detection of sucrose stimulus	G-protein coupled receptor activity|glucose binding	integral to membrane|plasma membrane
YMR236W	TAF9	het	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE	0.0139326084625071	0.41981167374649	1314	Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3	histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter	chromatin binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YJL082W	IML2	hom	FT	NUCLEUS|MITOCHONDRION	0.0139317364688859	0.419840772957913	1315	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|nucleus|cytoplasm
YER098W	UBP9	hom	FT	PROTEOLYSIS	0.0139205194401452	0.42014589582648	1316	Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication	protein deubiquitination	ubiquitin-specific protease activity	cytoplasm
YGL005C	COG7	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS	0.0139001375478396	0.421450825811932	1317	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	mitochondrion|Golgi transport complex
YHR132W-A	IGO2	hom	FT	NUCLEUS	0.0138997678069225	0.420839144923718	1318	Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p	mRNA stabilization	molecular_function	nucleus|cytoplasm
YOL099C_d	YOL099C	hom			0.0138997467226851	0.420839849625257	1319	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes	Unknown	Unknown	Unknown
YOR161C	PNS1	hom	FT	PLASMA MEMBRANE	0.0138696784858382	0.422053227323628	1320	Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport	biological_process	choline transmembrane transporter activity|molecular_function	integral to membrane|plasma membrane|integral to plasma membrane
YGR090W	UTP22	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0138568022973646	0.422484253444063	1321	Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	molecular_function	small-subunit processome|nucleolus|nucleus|UTP-C complex|90S preribosome|CURI complex
YPL265W	DIP5	hom	FT	PLASMA MEMBRANE	0.0138471148328352	0.422601130148373	1322	Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress	amino acid transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YMR086W	SEG1	hom			0.0138257097525576	0.423318665432064	1323	Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes	biological_process	molecular_function	eisosome|ribosome|cytoplasm
YOR040W	GLO4	hom	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|MITOCHONDRION	0.0137545306759525	0.425709831292804	1324	Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate	cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate	hydroxyacylglutathione hydrolase activity	mitochondrion|mitochondrial matrix
YEL017W	GTT3	hom	FT	ENDOMEMBRANE SYSTEM|NUCLEUS	0.0137245941021983	0.426717859810946	1325	Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery	biological_process	molecular_function	cellular_component
YER129W	SAK1	hom	FT	CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	0.0136845322454827	0.42813788041681	1326	Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome	protein phosphorylation|glucose metabolic process|DNA-dependent DNA replication	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YER120W	SCS2	hom	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH	0.0136442487941531	0.429430124134328	1327	Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication	endoplasmic reticulum inheritance|regulation of intracellular lipid transport|negative regulation of transcription factor import into nucleus|phospholipid biosynthetic process|chromatin silencing at telomere	phosphatidylinositol binding|FFAT motif binding	nuclear membrane|integral to endoplasmic reticulum membrane|nuclear envelope|endoplasmic reticulum|cellular bud tip
YDR015C_d	YDR015C	hom			0.0136433957253515	0.42945897530438	1328	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A	Unknown	Unknown	Unknown
YHR081W	LRP1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION|NUCLEUS	0.0136129684626387	0.431108060953228	1329	Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination	U5 snRNA 3'-end processing|nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear retention of pre-mRNA at the site of transcription|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	double-stranded RNA binding|double-stranded DNA binding	nuclear exosome (RNase complex)
YNL247W	YNL247W	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.0136091390900643	0.430618480140874	1330	Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments	cysteinyl-tRNA aminoacylation	cysteine-tRNA ligase activity	ribosome|cytoplasm
YBL028C	YBL028C	hom	FT	NUCLEUS	0.0135785972053353	0.431653779017144	1331	Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YBR022W	POA1	hom	FT	RNA PROCESSING	0.0135782093642837	0.431666935191729	1332	Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing	tRNA splicing, via endonucleolytic cleavage and ligation	phosphatase activity	cellular_component
YOR115C	TRS33	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0135662200138064	0.432073747260399	1333	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic	ER to Golgi vesicle-mediated transport|protein complex assembly	molecular_function	trans-Golgi network|TRAPP complex|cis-Golgi network
YNR049C	MSO1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0135482624535351	0.433026738430749	1334	Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress	cellular membrane fusion|ascospore-type prospore membrane assembly|vesicle docking involved in exocytosis	molecular_function	SNARE complex|cellular bud membrane|plasma membrane|prospore membrane|cellular bud neck|cellular bud tip
YBL020W	RFT1	het	FT	MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0135465731620535	0.432740866616473	1335	Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein	glycolipid translocation	molecular_function|glycolipid-translocating activity	integral to membrane|endoplasmic reticulum membrane
YIL146C	ATG32	hom	FT	CELL WALL ORG/BIOGENESIS|MITOCHONDRION	0.0135282597355788	0.4333632450847	1336	Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane	fungal-type cell wall organization|mitochondrion degradation	molecular_function	integral to mitochondrial outer membrane
YGR256W	GND2	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	0.0135022481354252	0.434248133468967	1337	6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	phosphogluconate dehydrogenase (decarboxylating) activity	cytosol|plasma membrane
YNR055C	HOL1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION|PLASMA MEMBRANE	0.0134706598823059	0.435392601014086	1338	Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake	organic alcohol transport|cation transport	alcohol transmembrane transporter activity|inorganic cation transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YMR102C_p	YMR102C	hom			0.0134646285490124	0.435529757876358	1339	Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene	biological_process	molecular_function	cellular_component
YOL081W	IRA2	hom	FT	SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE	0.0134639992021709	0.435619669074474	1340	GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication	negative regulation of cAMP biosynthetic process|negative regulation of Ras protein signal transduction|positive regulation of Ras GTPase activity|response to stress	Ras GTPase activator activity	mitochondrion|integral to membrane|cytoplasm
YDR245W	MNN10	hom	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0134428372083941	0.436478420409359	1341	Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family	N-glycan processing|cell wall mannoprotein biosynthetic process|substituted mannan metabolic process|barrier septum assembly	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YDL098C	SNU23	het	FT	RNA PROCESSING|NUCLEUS	0.0134358865469395	0.436784090199642	1342	Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome	mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YMR293C	HER2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION	0.0134183402225077	0.43745166375324	1343	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase	endoplasmic reticulum organization|glutaminyl-tRNAGln biosynthesis via transamidation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YPR195C_d	YPR195C	hom			0.0134077003312807	0.437473330428565	1344	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL165C	HAL5	hom	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS	0.013399056483276	0.438452823462561	1345	Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication	cellular cation homeostasis|protein phosphorylation|cellular protein localization|protein dephosphorylation	protein kinase activity	cellular_component
YLR215C	CDC123	het	FT	CELL CYCLE|TRANSLATION|CELL DIVISION	0.013382775850065	0.438394127401858	1346	Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein	regulation of mitotic cell cycle|regulation of translation	molecular_function	cytoplasm
YGL226W	MTC3	hom	FT	MITOCHONDRION	0.0133821126161803	0.438348537141879	1347	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1	biological_process	molecular_function	mitochondrion
YPR077C_d	YPR077C	hom			0.0133688203115027	0.438803586283906	1348	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1	Unknown	Unknown	Unknown
YHR137W	ARO9	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0133673932289609	0.438920714093782	1349	Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism	aromatic amino acid family metabolic process	aromatic-amino-acid:2-oxoglutarate aminotransferase activity	nucleus|cytoplasm
YAL012W	CYS3	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0133669895717359	0.43961799453042	1350	Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress	sulfur amino acid metabolic process|cysteine biosynthetic process|cysteine biosynthetic process via cystathionine|transsulfuration|cysteine metabolic process	cystathionine gamma-lyase activity	cytoplasm
YPL066W	RGL1	hom	FF|FT	SITE OF POLARIZED GROWTH	0.0133618743810167	0.439041481354079	1351	Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source	protein localization to bud neck	molecular_function	cellular bud neck|cytoplasm
YLR026C	SED5	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0133533344997162	0.439402298079036	1352	cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|cis-Golgi network
YNL283C	WSC2	hom	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0133500963658459	0.439445042399569	1353	Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response	fungal-type cell wall organization|response to heat|Rho protein signal transduction	transmembrane signaling receptor activity	site of polarized growth|cellular bud|mating projection tip|cytoplasm
YBR027C_d	YBR027C	hom			0.0133299590203925	0.440135519816195	1354	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR164W_d	YGR164W	hom			0.0133127140192153	0.440727317523845	1355	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR099C	YMR099C	hom	FT	CARBOHYDRATE METABOLISM|NUCLEUS	0.013305126864587	0.440987830704831	1356	Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS	cellular carbohydrate metabolic process	glucose-6-phosphate 1-epimerase activity	nucleus|cytoplasm
YNL236W	SIN4	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.01329060715587	0.442100092348387	1357	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding	core mediator complex
YNL317W	PFS2	het	FT	RNA PROCESSING|NUCLEUS	0.0132891548330046	0.441877173108112	1358	Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex	mRNA cleavage|mRNA polyadenylation	RNA binding	mRNA cleavage and polyadenylation specificity factor complex
YKR091W	SRL3	hom			0.0132798247852111	0.441857242308593	1359	Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate	nucleobase-containing compound metabolic process	molecular_function	cytoplasm
YOL064C	MET22	hom	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.01325562182739	0.442689803720278	1360	Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway	methionine biosynthetic process|hyperosmotic salinity response|sulfate assimilation	3'(2'),5'-bisphosphate nucleotidase activity	cellular_component
YOR075W	UFE1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0132363566215658	0.443353151082594	1361	t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER	retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum membrane fusion|vesicle fusion with endoplasmic reticulum	SNAP receptor activity	SNARE complex|integral to membrane|endoplasmic reticulum
YCR082W	AHC2	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0132293992874151	0.44359284828568	1362	Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex	histone acetylation	histone acetyltransferase activity	Ada2/Gcn5/Ada3 transcription activator complex|nucleus|cytoplasm
YDR360W_d	OPI7	hom			0.0132277267583788	0.443650482037826	1363	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.	Unknown	Unknown	Unknown
YKL203C	TOR2	het	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION|MITOCHONDRION|PLASMA MEMBRANE	0.0132172278272321	0.444012362805548	1364	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication	G1 phase of mitotic cell cycle|regulation of cell cycle|actin filament reorganization involved in cell cycle|positive regulation of endocytosis|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity|Rho protein signal transduction|ribosome biogenesis|signal transduction|TOR signaling cascade|cytoskeleton organization|negative regulation of autophagy	protein binding|protein serine/threonine kinase activity	TORC1 complex|TORC2 complex|mitochondrion|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|plasma membrane|cytoplasm
YGR291C_d	YGR291C	hom			0.0132086309077752	0.444308809781888	1365	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL018W	SWD2	het	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.0131989488889175	0.444642809312461	1366	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination	mRNA 3'-end processing|termination of RNA polymerase II transcription, exosome-dependent|histone H3-K4 methylation|termination of RNA polymerase II transcription, poly(A)-coupled|telomere maintenance|snoRNA 3'-end processing|histone H3-K79 methylation	histone methyltransferase activity (H3-K4 specific)	mRNA cleavage and polyadenylation specificity factor complex|Set1C/COMPASS complex
YMR278W	PGM3	hom	FT	CARBOHYDRATE METABOLISM|NUCLEUS	0.0131905606602736	0.4449322928239	1367	Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential	biological_process	phosphoglucomutase activity	nucleus|cytoplasm
YDR302W	GPI11	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.013182736337034	0.44520241239002	1368	ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog	GPI anchor biosynthetic process	mannose-ethanolamine phosphotransferase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YJR141W_p	YJR141W	het			0.0131744898451387	0.445487207630945	1369	Essential protein of unknown function	biological_process	molecular_function	cellular_component
YOL133W	HRT1	het	FT	CELL CYCLE|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.013170158548207	0.445636831917923	1370	RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF	G2/M transition of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle	ubiquitin-protein ligase activity	SCF ubiquitin ligase complex|nucleus|cytoplasm
YOL009C	MDM12	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0131693962776409	0.445663167451812	1371	Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins	mitochondrion inheritance|mitochondrion organization|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrion|ERMES complex
YER149C	PEA2	hom	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0131440155200213	0.446540548133093	1372	Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth	bipolar cellular bud site selection|regulation of initiation of mating projection growth|regulation of termination of mating projection growth|actin filament organization|pseudohyphal growth|establishment of cell polarity|filamentous growth|Rho protein signal transduction	cytoskeletal regulatory protein binding	polarisome|actin cap|mating projection tip
YMR201C	RAD14	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0131148754703036	0.447549093491742	1373	Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein	nucleotide-excision repair, DNA damage recognition	damaged DNA binding|zinc ion binding	nucleotide-excision repair factor 1 complex|nucleus
YLR059C	REX2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0131130560868456	0.447612105765975	1374	3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease	U5 snRNA 3'-end processing|U4 snRNA 3'-end processing|mitochondrial genome maintenance|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3'-5'-exoribonuclease activity|3'-5' exonuclease activity	mitochondrion
YDR053W_d	YDR053W	het			0.0131050031645271	0.447891070082237	1375	Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex	Unknown	Unknown	Unknown
YGL170C	SPO74	hom	FT	NUCLEUS|CYTOSKELETON	0.0130841305330072	0.448682241303904	1376	Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation	ascospore formation	structural molecule activity	spindle pole body
YML012W	ERV25	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0130831821010289	0.448647477856624	1377	Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	ER to Golgi transport vesicle
YGL214W_d	YGL214W	hom			0.013040744841672	0.450120601357483	1378	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C	Unknown	Unknown	Unknown
YLL052C	AQY2	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.0130389042511488	0.450184555656666	1379	Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains	water transport	water channel activity	plasma membrane|endoplasmic reticulum membrane
YBR067C	TIP1	hom	FT	CELL WALL ORG/BIOGENESIS	0.0130385513162408	0.450196819539723	1380	Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins	fungal-type cell wall organization	structural constituent of cell wall|lipase activity	fungal-type cell wall
YKL038W	RGT1	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|NUCLEUS	0.0130138066926818	0.451057124321697	1381	Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication	glucose transport|regulation of glucose import|negative regulation of transcription from RNA polymerase II promoter|glucose metabolic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nucleus
YOL060C	MAM3	hom	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	0.0129984690931221	0.451590838451251	1382	Protein required for normal mitochondrial morphology, has similarity to hemolysins	cellular manganese ion homeostasis|mitochondrion organization	molecular_function	fungal-type vacuole membrane|integral to membrane
YHR148W	IMP3	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0129982853465147	0.451597234585355	1383	Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA	rRNA processing|ribosome biogenesis	snoRNA binding	small-subunit processome|Mpp10 complex|90S preribosome
YGR283C	YGR283C	hom	FT	NUCLEUS	0.0129950676674148	0.451709248801934	1384	Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus	biological_process	S-adenosylmethionine-dependent methyltransferase activity	ribosome|nucleolus
YOL095C	HMI1	hom	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0129849831308333	0.452060414580868	1385	Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD	mitochondrial genome maintenance|mitochondrial DNA metabolic process	ATP-dependent 3'-5' DNA helicase activity	mitochondrion|mitochondrial matrix
YBR223C	TDP1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0129767298498144	0.4523479267493	1386	Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI	DNA repair	3'-tyrosyl-DNA phosphodiesterase activity|5'-tyrosyl-DNA phosphodiesterase activity	nucleus
YNR048W	YNR048W	hom			0.0129746710184746	0.45241966450741	1387	Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication	response to drug	phospholipid-translocating ATPase activity	integral to membrane
YBR245C	ISW1	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0129104672249688	0.454659998391775	1388	ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions	termination of RNA polymerase I transcription|nucleosome positioning|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|regulation of transcriptional start site selection at RNA polymerase II promoter|heterochromatin maintenance involved in chromatin silencing|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	nucleosome binding|ATPase activity|rDNA binding|DNA binding	ISW1 complex|nucleolar chromatin
YGR151C_d	YGR151C	hom			0.0129043641925201	0.455075080469324	1389	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress	Unknown	Unknown	Unknown
YGL129C	RSM23	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.012866255812065	0.456206341551983	1390	Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YPR108W	RPN7	het	FT	PROTEOLYSIS|NUCLEUS	0.0128624869508384	0.456539805007746	1391	Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits	ubiquitin-dependent protein catabolic process	structural molecule activity	nucleus|proteasome regulatory particle, lid subcomplex
YJL050W	MTR4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|OXIDATION-REDUCTION PROCESS|RNA LOCALIZATION|NUCLEUS	0.0128469436962677	0.45688273076174	1392	ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing	U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent 3'-5' RNA helicase activity|poly(A) RNA binding	nucleolus|nucleus|TRAMP complex
YDR191W	HST4	hom	FT	KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS	0.0128431617832717	0.457015254723497	1393	Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism	short-chain fatty acid metabolic process|chromatin silencing at telomere|histone deacetylation	histone deacetylase activity|DNA binding	nucleus|cytoplasm
YER180C	ISC10	hom	FT	CELL CYCLE	0.0128328014095728	0.457445492543217	1394	Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells	sporulation resulting in formation of a cellular spore	molecular_function	cellular_component
YNR026C	SEC12	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0128269506790665	0.457986216165326	1395	Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER	regulation of COPII vesicle coating	Sar guanyl-nucleotide exchange factor activity	Golgi apparatus|endoplasmic reticulum
YGL056C	SDS23	hom	FT	CELL DIVISION|NUCLEUS	0.0128147336642697	0.458079151432604	1396	One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication	cytokinetic cell separation	molecular_function	nucleus|cytoplasm
YKR085C	MRPL20	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0128016934899061	0.458469781639452	1397	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOL058W	ARG1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.012790258587476	0.458871324059439	1398	Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate	argininosuccinate metabolic process|arginine biosynthetic process|citrulline metabolic process	argininosuccinate synthase activity	cytosol
YOL138C	RTC1	hom			0.0127640768753483	0.459791449744741	1399	Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif	biological_process	molecular_function	ribosome|fungal-type vacuole|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YIL008W	URM1	hom	FT	RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0127532125855918	0.460173565380101	1400	Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response	cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|invasive growth in response to glucose limitation|tRNA wobble uridine modification	protein tag	cytosol|nucleus|cytoplasm
YHR103W	SBE22	hom	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS|GOLGI APPARATUS	0.0127481245016571	0.460352583033992	1401	Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth	fungal-type cell wall organization	molecular_function	cytoplasm
YDR460W	TFB3	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME	0.012741783072607	0.460642621253348	1402	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	holo TFIIH complex|TFIIK complex
YER187W_p	YER187W	hom			0.0127402295471848	0.460630433869238	1403	Putative protein of unknown function; induced in respiratory-deficient cells	biological_process	molecular_function	cellular_component
YDL073W_p	YDL073W	hom			0.0127302262259485	0.461183189405969	1404	Putative protein of unknown function; YDL073W is not an essential gene	biological_process	molecular_function	cellular_component
YNL206C	RTT106	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0127158496379728	0.461489038829448	1405	Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition	DNA replication-independent nucleosome assembly|negative regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|DNA replication-dependent nucleosome assembly|heterochromatin assembly involved in chromatin silencing	double-stranded DNA binding|histone binding	nucleus
YBR182C	SMP1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0127099410948245	0.461697258723143	1406	Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress	DNA binding, bending|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YOL056W	GPM3	hom	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0127073300193218	0.461789290980656	1407	Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event	biological_process	phosphoglycerate mutase activity|molecular_function	cytosol
YGL194C	HOS2	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|NUCLEUS|CHROMOSOME	0.0127041282295051	0.46190215804712	1408	Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS	negative regulation of meiosis|chromatin organization|regulation of transcription, DNA-dependent|positive regulation of stress-activated MAPK cascade|histone deacetylation	NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity	Rpd3L-Expanded complex|Set3 complex
YLR255C_d	YLR255C	hom			0.0126945063790992	0.4622414328459	1409	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL061C	SNP1	het	FT	RNA PROCESSING|NUCLEUS	0.0126903093866416	0.462389465972824	1410	Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress	mRNA splicing, via spliceosome	mRNA binding|U1 snRNA binding	commitment complex|U1 snRNP|U2-type prespliceosome
YDR457W	TOM1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|PROTEOLYSIS|RNA LOCALIZATION|NUCLEUS	0.012660021968772	0.463458524219828	1411	E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mitosis|nucleocytoplasmic transport|nucleus organization|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell size|protein ubiquitination	ubiquitin-protein ligase activity	integral to membrane|nucleolus|nucleus
YCR024C	SLM5	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0126572608210333	0.463556053168806	1412	Mitochondrial asparaginyl-tRNA synthetase	asparaginyl-tRNA aminoacylation|mitochondrial asparaginyl-tRNA aminoacylation	asparagine-tRNA ligase activity	mitochondrion
YML067C	ERV41	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0126277426153625	0.464599405780289	1413	Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein	ER to Golgi vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YOR027W	STI1	hom			0.0126200419525448	0.464871808589102	1414	Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop	protein folding	Hsp70 protein binding|Hsp90 protein binding|mRNA binding|ATPase inhibitor activity	cytoplasm
YAL042C-A_d	YAL042C-A	hom			0.0126154367854544	0.465034753924138	1415	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene	Unknown	Unknown	Unknown
YNL070W	TOM7	hom	FF|FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0126084125504903	0.465283354635837	1416	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex	protein import into mitochondrial matrix|protein import into mitochondrial outer membrane	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YDL195W	SEC31	het	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH	0.0126083226286667	0.465286537614688	1417	Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance	COPII-coated vesicle budding	structural molecule activity	COPII vesicle coat|mating projection tip
YMR085W_p	YMR085W	hom	FT	CARBOHYDRATE METABOLISM	0.0126079031557692	0.465501062635932	1418	Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1	biological_process	molecular_function	cellular_component
YMR142C	RPL13B	hom	FT	TRANSLATION|RIBOSOME	0.0126050778086041	0.465401403184775	1419	Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOL121C	RPS19A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME	0.0125867205999979	0.466051538948919	1420	Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit biogenesis|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YFL019C_d	YFL019C	hom			0.0125763734812163	0.46641821278007	1421	Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene	Unknown	Unknown	Unknown
YBL055C	YBL055C	hom	FT	RESPONSE TO OXIDATIVE STRESS	0.0125478575400661	0.467429568310461	1422	3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases	cellular response to oxidative stress|apoptotic DNA fragmentation	3'-5'-exodeoxyribonuclease activity|endonuclease activity	cytoplasm
YLR166C	SEC10	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH	0.0125338664204048	0.467926225853714	1423	Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion	exocytosis|establishment of cell polarity|Golgi to plasma membrane transport|vesicle fusion|vesicle docking involved in exocytosis	molecular_function	mating projection tip|exocyst
YLL007C_p	YLL007C	hom			0.0125100435309565	0.46877256408178	1424	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene	biological_process	molecular_function	cytoplasm
YJL169W_d	YJL169W	hom			0.0125090217321799	0.468808883700943	1425	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2	Unknown	Unknown	Unknown
YDR188W	CCT6	het			0.0124730000891961	0.470686656360826	1426	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif	protein folding	unfolded protein binding	chaperonin-containing T-complex
YLR010C	TEN1	het	FT	NUCLEUS|CHROMOSOME	0.0124316691113757	0.471562880245377	1427	Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p	negative regulation of telomere maintenance|telomere capping|telomere maintenance via telomerase	single-stranded telomeric DNA binding	nuclear telomere cap complex
YLL033W	IRC19	hom			0.0124268423578621	0.47173502289052	1428	Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci	mitotic recombination|ascospore formation	molecular_function	cellular_component
YER186C_p	YER186C	hom			0.0124114948224163	0.472282611568377	1429	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL201C	YIG1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.0123989282122207	0.472731239378533	1430	Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol	glycerol biosynthetic process	molecular_function	cytosol|nucleus
YIL103W	DPH1	hom			0.0123939657011565	0.473172570126041	1431	Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	molecular_function	cytoplasm
YMR242W-A_p	YMR242W-A	hom			0.0123939463737307	0.472909155833707	1432	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLL061W	MMP1	hom	FT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.0123875379941981	0.473138072527417	1433	High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p	S-methylmethionine transport	S-methylmethionine transmembrane transporter activity	integral to membrane|plasma membrane
YDR351W	SBE2	hom	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS|GOLGI APPARATUS	0.0123703646459683	0.473751830042067	1434	Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth	fungal-type cell wall organization	molecular_function	Golgi apparatus
YDL112W	TRM3	hom	FT	RNA PROCESSING	0.0123467239889934	0.474597437650233	1435	2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs	tRNA methylation	tRNA (guanine) methyltransferase activity	cytoplasm
YJR117W	STE24	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0123389516936592	0.474875627377522	1436	Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans	CAAX-box protein processing|peptide pheromone maturation	metalloendopeptidase activity	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|integral to membrane|nuclear inner membrane
YGR284C	ERV29	hom	FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0123376683874338	0.474921568695534	1437	Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|ER to Golgi transport vesicle
YMR234W	RNH1	hom	FT	CELL WALL ORG/BIOGENESIS|NUCLEUS	0.0123248181362152	0.475381731674629	1438	Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)	fungal-type cell wall organization|RNA catabolic process	ribonuclease H activity	intracellular|nucleus
YCR067C	SED4	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0123070081572327	0.476283102089763	1439	Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p	positive regulation of GTPase activity|regulation of COPII vesicle coating	Sar GTPase activator activity	integral to endoplasmic reticulum membrane
YGR155W	CYS4	hom	FT	KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|MITOCHONDRION	0.0122952991264932	0.477031971414034	1440	Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria	cysteine biosynthetic process from serine|hydrogen sulfide biosynthetic process|cysteine biosynthetic process via cystathionine|transsulfuration|traversing start control point of mitotic cell cycle	cystathionine beta-synthase activity	mitochondrion|cytoplasm
YPL272C_p	YPL272C	hom			0.0122909335594266	0.476925119607993	1441	Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene	biological_process	molecular_function	cellular_component
YGR095C	RRP46	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0122823604280533	0.476903864315534	1442	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)	nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing	molecular_function	nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YOR225W_d	YOR225W	hom			0.0122622149099157	0.477627024405474	1443	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL160W	AIM14	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0122612043824828	0.477728970977477	1444	NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p	biological_process	oxidoreductase activity, oxidizing metal ions	integral to membrane|ribosome
YLR116W	MSL5	het	FT	RNA PROCESSING|NUCLEUS	0.0122535191769086	0.477939358743541	1445	Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA	mRNA splicing, via spliceosome	pre-mRNA branch point binding	commitment complex
YJL044C	GYP6	hom	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM	0.0122525251737786	0.478040701564685	1446	GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport	intracellular protein transport	GTPase activator activity	endosome|clathrin-coated vesicle
YOR139C_d	YOR139C	hom			0.0122522933609048	0.477983396718834	1447	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W	Unknown	Unknown	Unknown
YPR189W	SKI3	hom	FT	NUCLEUS	0.0122400708688493	0.478422616348028	1448	Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	Ski complex
YIL022W	TIM44	het	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0121998171771123	0.479870704419382	1449	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)	protein import into mitochondrial matrix	protein binding, bridging|chaperone binding	mitochondrion|integral to membrane|presequence translocase-associated import motor
YOR066W	MSA1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS	0.0121977849118555	0.479943876524482	1450	Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation	G1/S transition of mitotic cell cycle|regulation of transcription involved in G1 phase of mitotic cell cycle|regulation of cell size	molecular_function	nucleus|cytoplasm
YEL005C	VAB2	hom			0.0121950175095598	0.480043527160096	1451	Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter	biological_process	molecular_function	cytoplasm
YMR055C	BUB2	hom	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON	0.0121936460705872	0.480092915111041	1452	Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint	GTPase activator activity	spindle pole body
YLR412W	BER1	hom	FT	CYTOSKELETON	0.0121412154946125	0.481983108133625	1453	Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene	biological_process	molecular_function	cytoplasm
YAL004W_d	YAL004W	hom			0.0120891930984229	0.484253941258355	1454	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C	Unknown	Unknown	Unknown
YOL065C	INP54	hom	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0120692507813329	0.484584106569418	1455	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins	phosphatidylinositol dephosphorylation	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	endoplasmic reticulum
YIL044C	AGE2	hom	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|GOLGI APPARATUS	0.0120620971466425	0.484908189452989	1456	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport	ARF GTPase activator activity	clathrin-coated vesicle
YOR232W	MGE1	het	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0120508580864178	0.485445385261995	1457	Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE	protein refolding|protein import into mitochondrial matrix	adenyl-nucleotide exchange factor activity	mitochondrion|presequence translocase-associated import motor|mitochondrial matrix
YCR037C	PHO87	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.0120370322540113	0.485751030200994	1458	Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication	phosphate ion transport|transmembrane transport	inorganic phosphate transmembrane transporter activity	integral to membrane|membrane
YDR389W	SAC7	hom	FF|FT	CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0119905861423868	0.487435934316577	1459	GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate	actin filament reorganization involved in cell cycle|small GTPase mediated signal transduction	Rho GTPase activator activity	intracellular
YMR307W	GAS1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|GENE SILENCING|NUCLEUS|MITOCHONDRION|PLASMA MEMBRANE	0.0119691360522232	0.488215132578338	1460	Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery	fungal-type cell wall organization|chromatin silencing|filamentous growth	1,3-beta-glucanosyltransferase activity	mitochondrion|membrane raft|primary cell septum|nuclear periphery|integral to membrane|fungal-type cell wall|plasma membrane|cellular bud scar|ER to Golgi transport vesicle
YMR196W_p	YMR196W	hom	FT	CARBOHYDRATE METABOLISM	0.0119592681256104	0.488573821303222	1461	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene	biological_process	molecular_function	cytoplasm
YGR270W	YTA7	hom	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0119555568505412	0.488708758970639	1462	Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p	negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter	chromatin binding|histone binding	extrinsic to endoplasmic reticulum membrane|nucleus
YOR097C_p	YOR097C	hom			0.0119290433418485	0.489738086941036	1463	Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene	biological_process	molecular_function	cellular_component
YPL122C	TFB2	het	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME	0.0119182897784544	0.490064858876452	1464	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	double-stranded DNA binding|core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YMR240C	CUS1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0119138402959239	0.490226904816969	1465	Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p	spliceosomal complex assembly|mRNA splicing, via spliceosome	molecular_function	U2 snRNP|U2-type prespliceosome
YIL001W_p	YIL001W	hom			0.0119132604012008	0.490248026155178	1466	Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm	biological_process	molecular_function	cytoplasm
YML088W	UFO1	hom	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0118952790264294	0.490903199277404	1467	F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|response to DNA damage stimulus	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex|nucleus|cytoplasm
YLR020C	YEH2	hom	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|PLASMA MEMBRANE	0.0118908563778558	0.491064415850242	1468	Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism	cell wall mannoprotein biosynthetic process|sterol metabolic process	sterol esterase activity	integral to membrane|plasma membrane
YGR046W	TAM41	het	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0118846807872564	0.491289579089717	1469	Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition	cardiolipin biosynthetic process|protein import into mitochondrial matrix	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YAR028W_p	YAR028W	hom			0.0118601137725037	0.492250392540314	1470	Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cellular_component
YMR159C	ATG16	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.0118579590260927	0.492264498115801	1471	Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway	protein binding, bridging|Atg8 ligase activity	Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YNL213C	RRG9	hom	FT	MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0118410150169388	0.492883221706615	1472	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	mitochondrion organization|mitochondrial genome maintenance	molecular_function	mitochondrion
YNL252C	MRPL17	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0118389505326845	0.492958636402976	1473	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDR329C	PEX3	hom	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION|ENDOPLASMIC RETICULUM	0.0118374056514416	0.493144051136767	1474	Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p	protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization	protein binding	peroxisomal membrane|endoplasmic reticulum
YML028W	TSA1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|TRANSLATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	0.0118339422052162	0.4931416140683	1475	Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	protein folding|cellular response to oxidative stress|replicative cell aging|DNA protection|DNA damage checkpoint|cell redox homeostasis|response to hydroperoxide	unfolded protein binding|ribosome binding|peroxiredoxin activity|thioredoxin peroxidase activity	cytosol|polysome|cytoplasm
YDL170W	UGA3	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0118209683404545	0.493615779200252	1476	Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus	nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process	sequence-specific DNA binding transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YMR187C_p	YMR187C	hom			0.0118164240759414	0.493781919363751	1477	Putative protein of unknown function; YMR187C is not an essential gene	biological_process	molecular_function	integral to membrane
YLR274W	MCM5	het	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0117878199957559	0.494828382640053	1478	Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase	S phase of mitotic cell cycle|establishment of chromatin silencing|DNA replication initiation|regulation of DNA-dependent DNA replication initiation|negative regulation of chromatin silencing at telomere|pre-replicative complex assembly|double-strand break repair via break-induced replication|chromatin silencing at telomere	DNA helicase activity|chromatin binding|DNA replication origin binding|single-stranded DNA binding	replication fork protection complex|nuclear chromosome, telomeric region|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YPL227C	ALG5	hom	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0117599038555263	0.49585081927136	1479	UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum	protein N-linked glycosylation	dolichyl-phosphate beta-glucosyltransferase activity	endoplasmic reticulum membrane
YPR069C	SPE3	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.0117598691498583	0.495852091077422	1480	Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells	spermidine biosynthetic process|pantothenate biosynthetic process	spermidine synthase activity	nucleus|cytoplasm
YOR069W	VPS5	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0117564446908589	0.496298959686051	1481	Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity|phosphatidylinositol-3-phosphate binding	cytosol|endosome|retromer complex, outer shell|retromer complex
YJL096W	MRPL49	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0117524544821363	0.496123845072797	1482	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YPL094C	SEC62	het	FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0117245877813811	0.49714589354702	1483	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	posttranslational protein targeting to membrane, translocation	protein transporter activity	integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YBR040W	FIG1	hom	FT	SITE OF POLARIZED GROWTH	0.0117140636586161	0.497532171270745	1484	Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating	cell morphogenesis involved in conjugation with cellular fusion|cytogamy	molecular_function	fungal-type cell wall|integral to membrane|mating projection tip
YGL077C	HNM1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0116440251050861	0.500106932136686	1485	Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol	choline transport|ethanolamine transport|glycine betaine transport	choline transmembrane transporter activity|ethanolamine transmembrane transporter activity	integral to membrane|plasma membrane
YNL293W	MSB3	hom	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH	0.0116428168762218	0.500215320075228	1486	Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress	actin filament organization|exocytosis	Rab GTPase activator activity	incipient cellular bud site|polarisome|cellular bud tip
YBR058C-A	TSC3	hom	FF|FT	KETONE METABOLISM|LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0116367263061034	0.500375656927271	1487	Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis	3-keto-sphinganine metabolic process|sphingolipid biosynthetic process	enzyme activator activity	SPOTS complex
YDR075W	PPH3	hom	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0116310356384304	0.500585227160182	1488	Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes	Unknown|signal transduction involved in meiotic recombination checkpoint|double-strand break repair via homologous recombination|protein dephosphorylation|positive regulation of nitrogen compound metabolic process	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus|cytoplasm
YOR312C	RPL20B	hom	FT	TRANSLATION|RIBOSOME	0.0116163751964177	0.50112534150561	1489	Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YJL188C_d	BUD19	hom			0.0116154291654416	0.501160205410321	1490	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YCL026C-B	HBN1	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEUS	0.0115999467658301	0.501730957887474	1491	Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress	biological_process	NAD(P)H nitroreductase activity	nucleus|cytoplasm
YGL172W	NUP49	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0115860862733994	0.502242211027038	1492	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)	poly(A)+ mRNA export from nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|tRNA export from nucleus	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|nuclear envelope|integral to membrane|nuclear pore
YDR484W	VPS52	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|GOLGI APPARATUS|CYTOSKELETON	0.0115723133541083	0.502941637759608	1493	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin	actin filament-based process|Golgi to vacuole transport|retrograde transport, endosome to Golgi	protein binding	Golgi apparatus|GARP complex
YLR031W_p	YLR031W	hom			0.0115462037596908	0.503714838298454	1494	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBL031W	SHE1	hom	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0115215237042264	0.504690809677525	1495	Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function	mitotic spindle elongation	molecular_function	microtubule cytoskeleton|nuclear microtubule|cellular bud neck|astral microtubule|spindle
YNL085W	MKT1	hom	FT	RESPONSE TO DNA DAMAGE|TRANSLATION	0.0115176690290427	0.504769854990049	1496	Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress	positive regulation of translation|interspecies interaction between organisms|response to DNA damage stimulus	nuclease activity	polysome|cytoplasm
YNL193W_p	YNL193W	hom			0.0115166293983007	0.504808315302669	1497	Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis	biological_process	molecular_function	cellular_component
YPL117C	IDI1	het	FT	LIPID METABOLISM|NUCLEUS	0.0114826110575483	0.506067648040983	1498	Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability	farnesyl diphosphate biosynthetic process	isopentenyl-diphosphate delta-isomerase activity	nucleus|cytoplasm
YBR292C_d	YBR292C	hom			0.0114787594596335	0.506210335272714	1499	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene	Unknown	Unknown	Unknown
YMR315W	YMR315W	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.0114621251386155	0.506826817238379	1500	Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress	NADPH regeneration	oxidoreductase activity	nucleus|cytoplasm
YBR031W	RPL4A	hom	FT	TRANSLATION|RIBOSOME	0.0114556586919729	0.507066575622307	1501	Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YMR222C	FSH2	hom			0.011447482913869	0.50736979664088	1502	Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2	biological_process	molecular_function	cytoplasm
YMR063W	RIM9	hom	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0114347975638793	0.508537221713012	1503	Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;	ascospore formation	molecular_function	integral to membrane
YJL204C	RCY1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH	0.0114006787470073	0.509107487190739	1504	F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth	early endosome to Golgi transport|endocytosis	SNARE binding	endosome|Golgi apparatus|site of polarized growth
YNL214W	PEX17	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION	0.0113966447220254	0.509257403505912	1505	Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis	protein import into peroxisome matrix, docking	protein binding	peroxisomal membrane
YER030W	CHZ1	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS	0.0113960078994839	0.509281071829496	1506	Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress	chromatin remodeling	histone binding	chromatin assembly complex|nucleus
YML007C-A_p	YML007C-A	hom	FF|FT	MITOCHONDRION	0.0113675149987504	0.510340635891141	1507	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria	biological_process	molecular_function	mitochondrion
YLR252W_d	YLR252W	hom			0.0113620553236522	0.510543796023835	1508	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism	Unknown	Unknown	Unknown
YJR102C	VPS25	hom	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.0113471746521929	0.511286776049464	1509	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome	negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	structural molecule activity	ESCRT II complex
YCR085W_d	YCR085W	hom			0.0113191898573145	0.512203242960651	1510	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL140C	RPO21	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION|RNA POL II, HOLOENZYME	0.0113043772414457	0.512692635703129	1511	RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime	transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	mitochondrion|DNA-directed RNA polymerase II, core complex
YHR012W	VPS29	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM	0.0112997816168722	0.512864051534086	1512	Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval	retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YNL140C_p	YNL140C	hom			0.0112786988533605	0.513650816583263	1513	Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C	biological_process	molecular_function	cellular_component
YFR011C	AIM13	hom	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.011276127332715	0.513746823350601	1514	Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial crista junction|cytoplasm|mitochondrial intermembrane space
YOR071C	NRT1	hom	FT	PLASMA MEMBRANE	0.0112698472995859	0.513981325279088	1515	High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity	thiamine transport|nicotinamide riboside transport	nicotinamide riboside transporter activity	integral to membrane|plasma membrane
YPL232W	SSO1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PLASMA MEMBRANE	0.0112626850452013	0.514248838040997	1516	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p	ascospore formation|ascospore-type prospore assembly|vesicle fusion	phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|SNAP receptor activity	SNARE complex|fungal-type vacuole membrane|plasma membrane|prospore membrane
YMR174C	PAI3	hom			0.0112496153304291	0.514925291859066	1517	Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact	vacuolar protein catabolic process	endopeptidase inhibitor activity	cytoplasm
YMR138W	CIN4	hom	FT	SIGNALING	0.0112432030625667	0.5149768630481	1518	GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog	protein folding|tubulin complex assembly|tubulin complex biogenesis	GTP binding	cytoplasm
YBR196C-B_p	YBR196C-B	hom			0.0112256964704856	0.515631525623052	1519	Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YGR007W	ECT1	hom	FT	LIPID METABOLISM|NUCLEUS	0.0111814918593754	0.517286485312299	1520	Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases	phosphatidylethanolamine biosynthetic process	ethanolamine-phosphate cytidylyltransferase activity	nucleus|cytoplasm
YJL190C	RPS22A	hom	FT	TRANSLATION|RIBOSOME	0.0111563911238904	0.518227444333086	1521	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YFR044C	DUG1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS|MITOCHONDRION	0.011153353306047	0.518341383923483	1522	Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	metallodipeptidase activity|omega peptidase activity	mitochondrion|ribosome|cytoplasm
YCR050C_p	YCR050C	hom			0.0111192245828137	0.519684607450181	1523	Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein	biological_process	molecular_function	cellular_component
YDR370C	DXO1	hom			0.0110792361604794	0.521125304623887	1524	Protein with decapping and 5&#8242;-3&#8242; exoRNase activity; similar to Rai1p	biological_process	molecular_function	cytoplasm
YNL175C	NOP13	hom	FT	NUCLEUS	0.0110585734796276	0.521902786679993	1525	Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress	biological_process	RNA binding	nucleolus|preribosome
YHR141C	RPL42B	hom	FT	TRANSLATION|RIBOSOME	0.0110575234923963	0.521942310836477	1526	Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR354W	TRP4	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0110519386970699	0.522897963540205	1527	Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis	tryptophan biosynthetic process	anthranilate phosphoribosyltransferase activity	nucleus|cytoplasm
YIL066C	RNR3	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|MITOCHONDRION	0.011027792882882	0.523062083810488	1528	Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits	deoxyribonucleotide biosynthetic process	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	mitochondrion|ribonucleoside-diphosphate reductase complex|cytoplasm
YGR170W	PSD2	hom	FT	LIPID METABOLISM|GOLGI APPARATUS	0.0110208099376505	0.52332526795253	1529	Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine	phosphatidylcholine biosynthetic process	phosphatidylserine decarboxylase activity	endosome
YML048W	GSF2	hom	FF|FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0110186633274567	0.523406186396573	1530	ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression	protein folding|protein localization to cell surface	unfolded protein binding	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|cytoplasm
YDR398W	UTP5	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|CHROMOSOME	0.0110089932879173	0.523770786972349	1531	Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit	positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|t-UTP complex|rDNA heterochromatin|nucleolus
YDR079W	PET100	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0109883885549319	0.524548104832048	1532	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme	mitochondrial respiratory chain complex IV assembly|aerobic respiration	unfolded protein binding	mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YMR123W	PKR1	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.010970542833565	0.526770040594707	1533	V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress	vacuolar proton-transporting V-type ATPase complex assembly	molecular_function	integral to endoplasmic reticulum membrane
YLR051C	FCF2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0109657596421703	0.525464222574647	1534	Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|nucleus
YDR014W	RAD61	hom	FT	CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0109641655736656	0.525462676613834	1535	Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin	mitotic sister chromatid cohesion	molecular_function	nuclear cohesin complex
YJL136C	RPS21B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0109390954435169	0.526410091530019	1536	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YOR194C	TOA1	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0109256576296879	0.52691827320056	1537	TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA	transcription initiation from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly	TBP-class protein binding|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly	transcription factor TFIIA complex
YMR134W	ERG29	het	FT	LIPID METABOLISM|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0109240449544954	0.527287488607857	1538	Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes	cellular iron ion homeostasis|mitochondrion organization	molecular_function	nuclear envelope|endoplasmic reticulum|cytoplasm
YDL024C	DIA3	hom			0.0109151612330817	0.527808444677317	1539	Protein of unknown function, involved in invasive and pseudohyphal growth	pseudohyphal growth|invasive growth in response to glucose limitation	acid phosphatase activity	fungal-type cell wall
YGR027C	RPS25A	hom	FT	TRANSLATION|RIBOSOME	0.0108961175590432	0.52803627777143	1540	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR418W	RPL12B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0108480370381036	0.529858563962761	1541	Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR112W_d	IRC2	hom			0.0108444065220833	0.531348846999074	1542	Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci	Unknown	Unknown	Unknown
YPL079W	RPL21B	hom	FT	TRANSLATION|RIBOSOME	0.0108373157662236	0.530265343001437	1543	Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR217W	ATG12	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.0108354538233969	0.530826878529832	1544	Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly	Atg8 ligase activity|protein tag	Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YNL100W	AIM37	hom	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0108176838383835	0.531010614662524	1545	Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YEL062W	NPR2	hom	FT	SIGNALING|RESPONSE TO NUTRIENT LEVELS	0.0108002821382339	0.53185528488969	1546	Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline	proline transport|urea transport|regulation of TOR signaling cascade|cellular response to amino acid starvation|response to drug|cellular response to nitrogen starvation	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YIL045W	PIG2	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0107940793415685	0.531907396592943	1547	Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase	regulation of glycogen biosynthetic process	protein phosphatase type 1 regulator activity	cytoplasm
YLR406C	RPL31B	hom	FT	TRANSLATION|RIBOSOME	0.0107901085440085	0.532241844207538	1548	Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication	cytoplasmic translation|regulation of translational fidelity	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR271W_p	YLR271W	hom	FT	NUCLEUS	0.0107815524871181	0.533792810137579	1549	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YER091C-A_d	YER091C-A	hom			0.0107804504121092	0.532425535847036	1550	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL137C	GIP3	hom	FT	CHROMOSOME SEGREGATION|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0107643079722462	0.533039562964101	1551	Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication	chromosome segregation|regulation of phosphoprotein phosphatase activity	protein phosphatase type 1 regulator activity|protein phosphatase 1 binding	mitochondrion|ribosome|endoplasmic reticulum|cytoplasm
YGL137W	SEC27	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0107613366131869	0.533152626702258	1552	Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP	retrograde vesicle-mediated transport, Golgi to ER|late endosome to vacuole transport via multivesicular body sorting pathway|ER to Golgi vesicle-mediated transport	ubiquitin binding	COPI vesicle coat
YGL042C_d	YGL042C	hom			0.0107565248941289	0.533518908612652	1553	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1	Unknown	Unknown	Unknown
YNL201C	PSY2	hom	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0107542870346328	0.533481954466834	1554	Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3	Unknown|response to DNA damage stimulus|protein dephosphorylation|signal transduction involved in meiotic recombination checkpoint	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus
YGR081C	SLX9	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.010753485431219	0.533634564704893	1555	Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	preribosome, small subunit precursor|nucleolus|nucleus|90S preribosome
YHR129C	ARP1	hom	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0106906412003657	0.535846241192088	1556	Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin	nuclear migration|establishment of mitotic spindle orientation	structural constituent of cytoskeleton	cell cortex|dynactin complex|spindle pole body|astral microtubule
YLL029W	FRA1	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS	0.0106773195460782	0.536536918588114	1557	Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation	negative regulation of transcription from RNA polymerase II promoter in response to iron	molecular_function	cytosol|cytoplasm
YIL142W	CCT2	het			0.0106369514625283	0.537896477697776	1558	Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	protein folding	unfolded protein binding	chaperonin-containing T-complex|cytoplasm
YDR035W	ARO3	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS|MITOCHONDRION	0.0106369402857401	0.538260830351747	1559	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan	aromatic amino acid family biosynthetic process	3-deoxy-7-phosphoheptulonate synthase activity	mitochondrion|nucleus|cytoplasm
YPR106W	ISR1	hom	FT	PROTEIN PHOSPHORYLATION	0.0106216317355258	0.538482209285562	1560	Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C	biological_process	protein kinase activity	cellular_component
YIL101C	XBP1	hom	FT	NUCLEUS	0.0105940523596186	0.539537479400251	1561	Transcriptional repressor; binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress	response to stress	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YCR063W	BUD31	hom	FT	CELL CYCLE|RNA PROCESSING|CELL DIVISION|NUCLEUS	0.0105834160553208	0.539944732896691	1562	Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis	RNA splicing|mRNA splicing, via spliceosome|cellular bud site selection	molecular_function	U2 snRNP|nucleus
YML060W	OGG1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION	0.0105708402472649	0.540426446367251	1563	Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance	DNA repair|base-excision repair, AP site formation	oxidized purine nucleobase lesion DNA N-glycosylase activity	mitochondrion
YIL109C	SEC24	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0105699714111591	0.540580517177868	1564	Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p	cargo loading into COPII-coated vesicle	signal sequence binding	COPII vesicle coat
YGL034C_d	YGL034C	hom			0.0105433587201023	0.541479867118459	1565	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBL057C	PTH2	hom	FT	PROTEOLYSIS|MITOCHONDRION	0.0105229156079688	0.542444841460374	1566	One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	aminoacyl-tRNA hydrolase activity	mitochondrial outer membrane|mitochondrion|cytoplasm
YBR056W-A_p	YBR056W-A	hom			0.0104980922997184	0.543217248740661	1567	Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B	biological_process	molecular_function	cellular_component
YDR290W_d	YDR290W	hom			0.0104573064850959	0.544785031636724	1568	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103	Unknown	Unknown	Unknown
YKL126W	YPK1	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0104413021785147	0.545580640151338	1569	Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication	eisosome assembly|protein autophosphorylation|negative regulation of phospholipid translocation|protein phosphorylation	protein serine/threonine kinase activity	cytosol|plasma membrane|cellular bud neck
YHR197W	RIX1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0103935005462579	0.547242192302966	1570	Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene	ribosomal large subunit assembly|ribosomal subunit export from nucleus|rRNA processing	molecular_function	nucleoplasm|nucleus
YJL130C	URA2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|MITOCHONDRION	0.0103703481163473	0.548135143527986	1571	Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP	glutamine metabolic process|'de novo' pyrimidine nucleobase biosynthetic process|negative regulation of pyrimidine nucleobase metabolic process	aspartate carbamoyltransferase activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	mitochondrion|integral to membrane|cytoplasm
YDR283C	GCN2	hom	FF|FT	KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION|RIBOSOME	0.0103661962906434	0.548474322685919	1572	Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control	cellular amino acid biosynthetic process|protein phosphorylation|regulation of translational initiation|DNA damage checkpoint	protein homodimerization activity|protein kinase activity|eukaryotic translation initiation factor 2alpha kinase activity	cytosolic ribosome
YKR083C	DAD2	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.010342443486174	0.549271893087532	1573	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis	mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization	microtubule binding|structural constituent of cytoskeleton	DASH complex|condensed nuclear chromosome kinetochore|mitotic spindle
YOR188W	MSB1	hom	FT	MITOCHONDRION|SITE OF POLARIZED GROWTH	0.010333204437663	0.549569215907496	1574	Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress	establishment of cell polarity	molecular_function	mitochondrion|cellular bud neck|cellular bud tip
YNR040W_p	YNR040W	hom	FT	MITOCHONDRION	0.010326096485067	0.549903353809063	1575	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YIR008C	PRI1	het	FT	NUCLEUS|CHROMOSOME	0.0102923631374276	0.551148180041493	1576	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair	lagging strand elongation|DNA replication, synthesis of RNA primer|DNA replication initiation|DNA replication	single-stranded DNA binding|DNA primase activity	alpha DNA polymerase:primase complex|nuclear replication fork
YNL068C	FKH2	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.010285202826153	0.551425234160394	1577	Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication	negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|negative regulation of transcription involved in G1 phase of mitotic cell cycle|Unknown|chromatin remodeling|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle	RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus
YNL211C_p	YNL211C	hom	FT	MITOCHONDRION	0.0102707929431879	0.551983003486561	1578	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene	biological_process	molecular_function	mitochondrion
YFR040W	SAP155	hom	FT	CELL CYCLE	0.0102682443135278	0.552081683169219	1579	Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress	G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	cytoplasm
YGL094C	PAN2	hom	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	0.0102168750217075	0.554072480425052	1580	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes	mRNA 3'-end processing|postreplication repair|mRNA processing	poly(A)-specific ribonuclease activity	PAN complex|cytoplasm
YMR209C_p	YMR209C	hom			0.0102062811039122	0.554483480081285	1581	Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YKL157W	APE2	hom	FT	PROTEOLYSIS|MITOCHONDRION	0.0101787157074132	0.555553600060221	1582	Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication	peptide catabolic process	metalloaminopeptidase activity	mitochondrion|extracellular region|cell wall-bounded periplasmic space
YNL120C_d	YNL120C	hom			0.0101596690130381	0.55629360276624	1583	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene	Unknown	Unknown	Unknown
YIL125W	KGD1	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0101542594295017	0.556503863643985	1584	Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA	tricarboxylic acid cycle|2-oxoglutarate metabolic process	oxoglutarate dehydrogenase (succinyl-transferring) activity	mitochondrial nucleoid|mitochondrion|mitochondrial matrix|mitochondrial oxoglutarate dehydrogenase complex
YDR175C	RSM24	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.010149400478412	0.556987051227876	1585	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YPR057W	BRR1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0101437709406678	0.556911642834434	1586	snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed	spliceosomal complex assembly	RNA binding	small nuclear ribonucleoprotein complex
YJL182C_d	YJL182C	hom			0.0101296654716162	0.557460274989877	1587	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W	Unknown	Unknown	Unknown
YNR030W	ALG12	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0101241811612219	0.558320442839179	1588	Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation	dolichol-linked oligosaccharide biosynthetic process|protein glycosylation	alpha-1,6-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YBR028C	YPK3	hom	FT	PROTEIN PHOSPHORYLATION	0.0101163683532463	0.558153872035421	1589	An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner	biological_process	protein kinase activity	cytoplasm
YML049C	RSE1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|NUCLEUS	0.0100578994934116	0.560314164217572	1590	Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport	spliceosomal complex assembly|mRNA splicing, via spliceosome	U2 snRNA binding	U2 snRNP|U2-type prespliceosome
YML094C-A_d	YML094C-A	hom	FF		0.0100572252820489	0.560281971904175	1591	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YEL041W	YEF1	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.0100410897055782	0.560911427148452	1592	ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication	NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	cellular_component
YNL232W	CSL4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0100343983054101	0.561289364645259	1593	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)	nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing	molecular_function	nucleus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|cytoplasm
YPR070W	MED1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0100284738012205	0.56140381682319	1594	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	molecular_function	core mediator complex
YER059W	PCL6	hom	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.00999725904881966	0.562739519459549	1595	Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding	regulation of glycogen catabolic process|regulation of glycogen biosynthetic process	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YDR115W	YDR115W	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00998704879899808	0.56302207293146	1596	Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrial large ribosomal subunit
YPR042C	PUF2	hom			0.00996362700296807	0.564112432453003	1597	Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	mRNA binding	cytoplasm
YOR072W_d	YOR072W	hom	FF		0.00994711792963947	0.564584087104357	1598	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive	Unknown	Unknown	Unknown
YDR516C	EMI2	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.00994122246705752	0.565221363781136	1599	Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YBR046C	ZTA1	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.00989886396363996	0.56647446051969	1600	NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin	cellular response to oxidative stress	NADPH:quinone reductase activity|AU-rich element binding|2-alkenal reductase [NAD(P)] activity	nucleus|cytoplasm
YER183C	FAU1	hom	FT	COFACTOR METABOLISM|MITOCHONDRION	0.0098932270281621	0.566753334393149	1601	5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis	folic acid-containing compound biosynthetic process	5-formyltetrahydrofolate cyclo-ligase activity	mitochondrion
YFL029C	CAK1	het	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	0.00988721871639222	0.566931123088192	1602	Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases	G2/M transition of mitotic cell cycle|meiosis|G1 phase of mitotic cell cycle|protein phosphorylation	cyclin-dependent protein kinase activating kinase activity	cytoplasm
YAR014C	BUD14	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH	0.00985017034421417	0.568500493226693	1603	Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress	regulation of cell shape during vegetative growth phase|regulation of protein localization|regulation of transcription, DNA-dependent|cytoskeleton organization|negative regulation of actin filament polymerization	protein phosphatase type 1 regulator activity	incipient cellular bud site|cellular bud neck|cellular bud tip
YBL013W	FMT1	hom	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION	0.00982830443329883	0.569244116518906	1604	Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate	translational initiation|methionyl-tRNA aminoacylation	methionyl-tRNA formyltransferase activity	mitochondrion
YPR032W	SRO7	hom	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|PLASMA MEMBRANE	0.00981753937967027	0.569667242085914	1605	Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication	establishment of cell polarity|exocytosis|Golgi to plasma membrane transport|small GTPase mediated signal transduction	SNARE binding|Rab GTPase binding	cytosol|plasma membrane
YHR147C	MRPL6	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0098121394888579	0.570224870460382	1606	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YKL078W	DHR2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00980094455971249	0.570319803080579	1607	Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosome biogenesis	RNA helicase activity	nucleolus
YCL011C	GBP2	hom	FT	RNA LOCALIZATION|NUCLEUS|CHROMOSOME	0.00979613585504056	0.570681384447874	1608	Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication	poly(A)+ mRNA export from nucleus|telomere maintenance	RNA binding|telomeric DNA binding	nucleus|cytoplasmic stress granule
YGR108W	CLB1	hom	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.00978992447412431	0.570753344493548	1609	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|meiotic G2/MI transition|regulation of cyclin-dependent protein kinase activity|mitotic spindle organization in nucleus|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YBL095W_p	YBL095W	hom	FT	MITOCHONDRION	0.0097831368667261	0.571020453947657	1610	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPR173C	VPS4	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM	0.00976891870856254	0.571580167015169	1611	AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism	late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport	ATPase activity|protein homodimerization activity|ATP binding	endosome|endoplasmic reticulum|membrane|cytoplasm
YNR037C	RSM19	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.00975375007383176	0.572177584005354	1612	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YCR008W	SAT4	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS	0.00974912230428219	0.572359907822836	1613	Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p	cellular cation homeostasis|protein phosphorylation|cellular protein localization|G1/S transition of mitotic cell cycle|protein dephosphorylation	protein kinase activity	cellular_component
YDR141C	DOP1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS	0.00971671380959928	0.573637502669279	1614	Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies	endoplasmic reticulum organization|cell morphogenesis|Golgi to endosome transport	molecular_function	trans-Golgi network|endosome|mitochondrion|cytoplasm
YJL110C	GZF3	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.00970482781989172	0.574106405819764	1615	GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication	maintenance of protein location in nucleus|nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YBR298C	MAL31	hom	FT	CARBOHYDRATE METABOLISM	0.00970147339034783	0.574695753166891	1616	Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C	alpha-glucoside transport|transmembrane transport	alpha-glucoside:hydrogen symporter activity	integral to membrane|membrane
YMR258C	ROY1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|NUCLEUS	0.00969277405440526	0.574639161415628	1617	GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p	endocytosis|protein targeting to vacuole|negative regulation of GTPase activity	GTPase inhibitor activity	nucleus|cytoplasm
YLR087C	CSF1	hom	FF|FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.00968624906504399	0.575010802252132	1618	Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	fermentation	molecular_function	mitochondrion
YBR061C	TRM7	hom	FT	RNA PROCESSING|TRANSLATION	0.00967477048338236	0.575349954546035	1619	2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively	cytoplasmic translation|tRNA methylation	tRNA methyltransferase activity	cytoplasm
YMR314W	PRE5	het	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	0.00967033382668975	0.575753123597395	1620	Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YDR256C	CTA1	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.00966456737600009	0.575696029860119	1621	Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation	response to reactive oxygen species|age-dependent response to reactive oxygen species|hydrogen peroxide catabolic process	catalase activity	peroxisomal matrix|mitochondrial matrix
YPL249C-A	RPL36B	hom	FT	TRANSLATION|RIBOSOME	0.00966389327472927	0.575722663428502	1622	Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YPR006C	ICL2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.00964824037575185	0.576511907575241	1623	2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol	threonine catabolic process|propionate metabolic process	methylisocitrate lyase activity	mitochondrion|mitochondrial matrix
YOR211C	MGM1	hom	FT	MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00962330245324732	0.577327467337775	1624	Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy	mitochondrion organization|mitochondrial genome maintenance|mitochondrial fusion	GTPase activity	intrinsic to mitochondrial inner membrane|extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial inner boundary membrane|mitochondrial crista|mitochondrial intermembrane space
YDL045W-A	MRP10	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.00960243324212022	0.57843689546546	1625	Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs	mitochondrial translation|mitochondrial respiratory chain complex assembly	structural constituent of ribosome	mitochondrial small ribosomal subunit
YOR192C	THI72	hom			0.0095751007329659	0.579462255602858	1626	Transporter of thiamine or related compound; shares sequence similarity with Thi7p	thiamine transport	transporter activity	integral to membrane|membrane
YKR013W	PRY2	hom			0.00956507398859557	0.579633265737398	1627	Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication	biological_process	molecular_function	extracellular region|fungal-type vacuole
YDR306C_p	YDR306C	hom	FT	PROTEOLYSIS	0.00950853817475329	0.581876159849444	1628	F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YCR079W	PTC6	hom	FT	RESPONSE TO NUTRIENT LEVELS|MITOCHONDRION	0.00947850028538814	0.583069472611648	1629	Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase	mitochondrion degradation|positive regulation of catalytic activity|macroautophagy|protein dephosphorylation	protein serine/threonine phosphatase activity	mitochondrion|mitochondrial matrix|mitochondrial intermembrane space
YBR200W-A_p	YBR200W-A	hom			0.0094483731331144	0.584267476093806	1630	Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YDR519W	FPR2	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00941482594193542	0.585602822852255	1631	Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress	biological_process	FK506 binding|peptidyl-prolyl cis-trans isomerase activity	endoplasmic reticulum membrane
YDL203C	ACK1	hom	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|MITOCHONDRION	0.00941394827412466	0.585637777444871	1632	Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria	fungal-type cell wall organization|positive regulation of signal transduction	molecular_function	mitochondrion
YJL060W	BNA3	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.00932416938448687	0.589218475861873	1633	Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate	kynurenic acid biosynthetic process	arylformamidase activity|kynurenine-oxoglutarate transaminase activity	mitochondrion|cytoplasm
YAL038W	CDC19	het	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.00932311432156005	0.589649502745386	1634	Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication	pyruvate metabolic process|glycolysis	pyruvate kinase activity	cytosol|plasma membrane
YNL259C	ATX1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	0.00930930010218773	0.5899789150233	1635	Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake	copper ion transport|cellular response to oxidative stress|cellular iron ion homeostasis	copper chaperone activity	cytosol
YNR057C	BIO4	hom	FT	KETONE METABOLISM|COFACTOR METABOLISM	0.00929797654797053	0.590265037607314	1636	Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels	biotin biosynthetic process	dethiobiotin synthase activity	cytoplasm
YDR297W	SUR2	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00927673179354293	0.59111452153677	1637	Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis	sphingolipid metabolic process	sphingosine hydroxylase activity	integral to membrane|endoplasmic reticulum membrane
YLR436C	ECM30	hom	FT	CELL WALL ORG/BIOGENESIS	0.00926411491128046	0.591619280724156	1638	Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm	fungal-type cell wall organization	molecular_function	cytoplasm
YEL044W	IES6	hom	FT	NUCLEUS	0.00924499275496648	0.592550279017219	1639	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes	biological_process	molecular_function	nucleus
YBR296C-A_p	YBR296C-A	hom			0.00923818608578714	0.592657226947071	1640	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YOR204W	DED1	het	FT	TRANSLATION	0.00923438374296767	0.592809507120916	1641	ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility	translational initiation	RNA strand annealing activity|ATP-dependent RNA helicase activity	cytoplasm
YPR083W	MDM36	hom	FT	MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00922985095178926	0.593046191942873	1642	Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission	mitochondrial fission|mitochondrion organization	molecular_function	mitochondrion|cytoplasm
YLR330W	CHS5	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH	0.0092001039545377	0.594183188324579	1643	Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane	ascospore wall assembly|conjugation with cellular fusion|cell wall chitin catabolic process|Golgi to plasma membrane transport|cellular bud site selection|regulation of transcription, DNA-dependent	molecular_function	mating projection tip|cytoplasm|exomer complex
YCR075C	ERS1	hom			0.00918658474436709	0.594725338349005	1644	Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains	L-cystine transport|transmembrane transport	L-cystine transmembrane transporter activity	endosome|integral to membrane|fungal-type vacuole
YJL036W	SNX4	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	0.00917094508348549	0.59535280474673	1645	Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p	piecemeal microautophagy of nucleus|mitochondrion degradation|early endosome to Golgi transport|CVT pathway|protein targeting to vacuole	phosphatidylinositol-3-phosphate binding	cytosol|pre-autophagosomal structure|extrinsic to membrane|early endosome
YMR311C	GLC8	hom	FT	SIGNALING|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION|NUCLEUS	0.00916758649807154	0.595487591254662	1646	Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress	chromosome segregation|glycogen biosynthetic process	enzyme activator activity	nucleus|cytoplasm
YML081W	TDA9	hom	FT	NUCLEUS	0.00916402949219914	0.595630355928282	1647	DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication	biological_process	sequence-specific DNA binding	nucleus
YDR231C	COX20	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.00916175266973975	0.59572174710301	1648	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase	mitochondrial respiratory chain complex IV assembly|protein processing|aerobic respiration	unfolded protein binding	mitochondrion|mitochondrial inner membrane
YLR204W	QRI5	hom	FF|FT	RNA PROCESSING|MITOCHONDRION	0.00915580385421673	0.595960561467571	1649	Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA	mRNA processing	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YOR323C	PRO2	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS	0.00915232816492096	0.596978094517292	1650	Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis	proline biosynthetic process	glutamate-5-semialdehyde dehydrogenase activity	nucleus|cytoplasm
YDL126C	CDC48	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION|SITE OF POLARIZED GROWTH|UBIQUITI	0.00913225088787738	0.597015947664655	1651	AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP	proteasomal ubiquitin-dependent protein catabolic process|mitotic spindle disassembly|ER-associated protein catabolic process|mitochondria-associated protein catabolic process|macroautophagy|sister chromatid biorientation|ER-associated misfolded protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|retrograde protein transport, ER to cytosol|piecemeal microautophagy of nucleus|endoplasmic reticulum membrane fusion|ribophagy|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process	ubiquitin binding|ATPase activity	mitochondrion|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytosol|Doa10p ubiquitin ligase complex|nucleus|endoplasmic reticulum membrane|mating projection tip
YDR509W_d	YDR509W	hom			0.00912328606183081	0.59726675383712	1652	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL180W	TCO89	hom	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PLASMA MEMBRANE	0.00911830428873606	0.59746697929984	1653	Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin	TOR signaling cascade|fungal-type cell wall organization|response to salt stress|regulation of cell growth|glycerol metabolic process	molecular_function	TORC1 complex|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|extrinsic to vacuolar membrane
YER058W	PET117	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0090832270652864	0.598877651780579	1654	Protein required for assembly of cytochrome c oxidase	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion
YGR223C	HSV2	hom	FT	MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	0.00906539583362532	0.599595334294976	1655	Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization	piecemeal microautophagy of nucleus	phosphatidylinositol binding	endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YBR156C	SLI15	hom	FT	CELL DIVISION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON	0.00905983169400004	0.600254811318667	1656	Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly	chromosome segregation|protein phosphorylation|regulation of cytokinesis	protein kinase activator activity	spindle microtubule|spindle midzone|chromosome passenger complex|kinetochore microtubule
YHR200W	RPN10	hom	FT	PROTEOLYSIS	0.00903798793299556	0.600699222850454	1657	Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein	ubiquitin-dependent protein catabolic process	structural molecule activity|polyubiquitin binding	proteasome complex|proteasome regulatory particle, base subcomplex
YNL288W	CAF40	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.00901822742078855	0.601495672020356	1658	Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p	positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	molecular_function	CCR4-NOT core complex
YKL136W_d	YKL136W	hom			0.00899541966777741	0.602415532130646	1659	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C	Unknown	Unknown	Unknown
YBR082C	UBC4	hom	FT	PROTEOLYSIS	0.00897655174967058	0.603176973030558	1660	Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress	ubiquitin binding|ubiquitin-protein ligase activity	proteasome complex
YCR081W	SRB8	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0089669605122822	0.603726202741552	1661	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity	mediator complex
YCR071C	IMG2	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.00894501439907052	0.604774175917664	1662	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YCR010C	ADY2	hom	FT	CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION|PLASMA MEMBRANE	0.00889701254635586	0.606445313356111	1663	Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication	nitrogen utilization|ammonium transport|acetate transport|transmembrane transport	acetate transmembrane transporter activity|ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YNR018W	RCF2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00889163992118146	0.606609049794159	1664	Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion|mitochondrial respiratory chain supercomplex|mitochondrial respiratory chain complex IV|integral to mitochondrial inner membrane
YOL021C	DIS3	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION	0.00888916960929895	0.606762673496577	1665	Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress	nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nonfunctional rRNA decay|nuclear polyadenylation-dependent mRNA catabolic process|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing	3'-5'-exoribonuclease activity|endoribonuclease activity|tRNA binding	mitochondrion|nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YML021C	UNG1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION	0.0088529772554132	0.608174653098633	1666	Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus	DNA repair	uracil DNA N-glycosylase activity	mitochondrion|nucleus
YKL193C	SDS22	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS	0.00883972899318019	0.608818401151355	1667	Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function	maintenance of protein location in nucleus|chromosome segregation	protein serine/threonine phosphatase inhibitor activity|protein phosphatase type 1 activator activity	protein phosphatase type 1 complex|nucleus|cytoplasm
YLR131C	ACE2	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|NUCLEUS	0.00874503968451896	0.613032326919549	1668	Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication	Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YNR035C	ARC35	het	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.00874450455618609	0.612841805657981	1669	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin	mitochondrion inheritance|receptor-mediated endocytosis|microtubule cytoskeleton organization|actin cytoskeleton organization	structural molecule activity	cytosol|Arp2/3 protein complex
YKR048C	NAP1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME	0.00873931556496485	0.612787649218422	1670	Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress	budding cell bud growth|M phase of mitotic cell cycle|nucleosome disassembly|protein import into nucleus|nucleosome assembly	cyclin binding|histone binding	nucleus|nuclear nucleosome|cytoplasm
YPR059C_d	YPR059C	hom			0.0087271161294705	0.613548381372324	1671	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W	Unknown	Unknown	Unknown
YKL058W	TOA2	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.00872327136173593	0.613492953261501	1672	TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress	transcription initiation from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly	TBP-class protein binding|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|TBP-class protein binding RNA polymerase II transcription factor activity	transcription factor TFIIA complex
YIL065C	FIS1	hom	FT	MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION|MITOCHONDRION	0.00871612876302469	0.613730587398823	1673	Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation	peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization	molecular_function	mitochondrial outer membrane|mitochondrion|peroxisome
YPR161C	SGV1	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.00871405780410588	0.613814838236618	1674	Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins	phosphorylation of RNA polymerase II C-terminal domain|protein phosphorylation|transcription, DNA-dependent|positive regulation of histone H3-K4 methylation	RNA polymerase II carboxy-terminal domain kinase activity|cyclin-dependent protein kinase activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YGR233C	PHO81	hom	FT	LIPID METABOLISM|NUCLEUS	0.0087070873281338	0.614098448877158	1675	Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress	phosphate-containing compound metabolic process	cyclin-dependent protein kinase inhibitor activity	nucleus|cytoplasm
YPR087W_d	VPS69	hom			0.00868434763862538	0.615235032397496	1676	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YKR074W	AIM29	hom			0.00865994240906437	0.616281341306545	1677	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cytoplasm
YHR013C	ARD1	hom	FT	CHROMATIN ORGANIZATION|RIBOSOME	0.00864296262855213	0.616710220021848	1678	Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress	histone acetylation|N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	cytosolic ribosome|NatA complex
YMR275C	BUL1	hom	FT	MITOCHONDRION ORGANIZATION|PLASMA MEMBRANE|UBIQUITIN LIGASE COMPLEX	0.00861477174422753	0.617859961057199	1679	Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication	mitochondrion inheritance|protein monoubiquitination|protein polyubiquitination	ubiquitin-ubiquitin ligase activity	ubiquitin ligase complex|plasma membrane
YAL041W	CDC24	het	FT	CELL CYCLE|SIGNALING|NUCLEUS|SITE OF POLARIZED GROWTH	0.00860724057130712	0.618167272075391	1680	Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of exit from mitosis|establishment of cell polarity|small GTPase mediated signal transduction	Rho guanyl-nucleotide exchange factor activity	incipient cellular bud site|nucleus|cellular bud neck|mating projection tip|cellular bud tip|cytoplasm
YCL005W-A	VMA9	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS	0.00855252744212418	0.620401854547183	1681	Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis	cell wall mannoprotein biosynthetic process|vacuolar acidification|protein complex assembly|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions	vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane
YJL176C	SWI3	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|RSC COMPLEX	0.00854978256078104	0.620514052983046	1682	Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	histone binding|DNA binding	SWI/SNF complex|nucleus
YGR282C	BGL2	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.00852731952423364	0.62143257265686	1683	Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance	fungal-type cell wall organization	1,3-beta-glucanosyltransferase activity|glucan endo-1,3-beta-D-glucosidase activity	fungal-type cell wall
YGR242W_d	YGR242W	hom			0.00852039767779385	0.62171572780639	1684	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C	Unknown	Unknown	Unknown
YHR143W	DSE2	hom	FF|FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION	0.00851963336678395	0.621746997260666	1685	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP	cytokinesis, completion of separation|pseudohyphal growth	glucosidase activity	extracellular region|fungal-type cell wall
YCR092C	MSH3	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.00849429051081086	0.622784209192637	1686	Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability	mismatch repair|mitotic recombination|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination	DNA insertion or deletion binding|mismatched DNA binding|double-strand/single-strand DNA junction binding|loop DNA binding|Y-form DNA binding	MutSbeta complex|nucleus|cytoplasm
YHR104W	GRE3	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.008487714771177	0.62305345816534	1687	Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress	galactose catabolic process|cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process|response to stress	D-xylose:NADP reductase activity|mRNA binding|glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity	nucleus|cytoplasm
YBL046W	PSY4	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.00845767358028488	0.624284159385763	1688	Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2	Unknown|protein dephosphorylation	protein phosphatase regulator activity	nucleus|cytoplasm
YNL258C	DSL1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.00843514541135313	0.625259342548027	1689	Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p; similar to the fly and human ZW10 gene	retrograde vesicle-mediated transport, Golgi to ER|ER-dependent peroxisome organization	molecular_function	Dsl1p complex|endoplasmic reticulum|peroxisome|nucleus
YMR262W_p	YMR262W	hom			0.00840017295543219	0.626642716844134	1690	Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene	biological_process	molecular_function	cellular_component
YBR281C	DUG2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS|NUCLEUS	0.00832241775280099	0.629838150317276	1691	Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	peptidase activity|gamma-glutamyltransferase activity|omega peptidase activity	nucleus|cytoplasm
YLR425W	TUS1	hom	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|SITE OF POLARIZED GROWTH	0.00830963649439814	0.630364075253154	1692	Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate	fungal-type cell wall organization|signal transduction	Rho guanyl-nucleotide exchange factor activity	incipient cellular bud site|cellular bud neck
YPR137W	RRP9	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00827056304308789	0.632125486827025	1693	Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein	rRNA modification|rRNA processing	snoRNA binding	box C/D snoRNP complex|small-subunit processome|nucleolus|90S preribosome
YDL058W	USO1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|CYTOSKELETON	0.00821193183021395	0.634643351159492	1694	Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex	Golgi vesicle docking|ER to Golgi vesicle-mediated transport|SNARE complex assembly	molecular_function	integral to membrane|ER to Golgi transport vesicle membrane|Golgi membrane
YGR261C	APL6	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00819238008065262	0.635197669819846	1695	Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools	vesicle-mediated transport|Golgi to vacuole transport	molecular_function	AP-3 adaptor complex
YHR051W	COX6	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.00813770044290309	0.637457038136938	1696	Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YPL188W	POS5	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.00812629520651376	0.637928729381532	1697	Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress	cellular response to oxidative stress|NADP biosynthetic process	NADH kinase activity	mitochondrion|mitochondrial matrix
YMR071C	TVP18	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00811866124652445	0.638394809387208	1698	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments	vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|clathrin-coated vesicle
YDR136C_d	VPS61	hom	FF		0.00810105767598975	0.639273137643228	1699	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YML127W	RSC9	het	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|NUCLEUS|RSC COMPLEX	0.00807626001822976	0.639999785938994	1700	Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway	G2/M transition of mitotic cell cycle|ATP-dependent chromatin remodeling|nucleosome disassembly|rRNA transcription|regulation of transcription from RNA polymerase II promoter|chromatin remodeling|transcription elongation from RNA polymerase II promoter|response to stress	chromatin binding|DNA translocase activity	RSC complex
YOR123C	LEO1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|RNA POL II, HOLOENZYME	0.00801861506797562	0.642538132660994	1701	Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	chromatin organization|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription-coupled nucleotide-excision repair|histone H3-K4 trimethylation|transcription elongation from RNA polymerase II promoter	RNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|Cdc73/Paf1 complex
YOR250C	CLP1	het	FT	RNA PROCESSING|NUCLEUS	0.00800861756081029	0.64280410315384	1702	Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation	mRNA 3'-end processing|mRNA cleavage|mRNA polyadenylation	RNA binding	mRNA cleavage factor complex
YCR026C	NPP1	hom	FT	NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS	0.00798925479967154	0.643607783271777	1703	Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication	cellular response to phosphate starvation|phosphate-containing compound metabolic process|nucleoside triphosphate metabolic process	nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity	cellular_component
YPL219W	PCL8	hom	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.00795338325564944	0.645097785838277	1704	Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation	negative regulation of glycogen biosynthetic process	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YDR003W-A_p	YDR003W-A	hom			0.00793109135503735	0.646024446997818	1705	Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YOR282W_d	YOR282W	het			0.0079127044718695	0.647280428040821	1706	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C	Unknown	Unknown	Unknown
YOL146W	PSF3	het	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.00791130205498397	0.646847536881758	1707	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery	double-strand break repair via break-induced replication|DNA-dependent DNA replication	molecular_function	replication fork protection complex|GINS complex|DNA replication preinitiation complex
YCR017C	CWH43	hom	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.00789647684036604	0.647464440330303	1708	Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion	fungal-type cell wall organization|GPI anchor biosynthetic process	molecular_function	integral to membrane|integral to plasma membrane|cellular bud neck|cellular bud tip
YAL002W	VPS8	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.00786947767194417	0.648735185893779	1709	Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif	late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole	GTPase binding|protein anchor	late endosome|membrane|CORVET complex
YGL246C	RAI1	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00786493530807689	0.64951140525039	1710	Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z	deadenylation-dependent decapping of nuclear-transcribed mRNA|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|termination of RNA polymerase II transcription, poly(A)-coupled|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	enzyme regulator activity|m7G(5')pppN diphosphatase activity	nucleus
YMR319C	FET4	hom	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.00785922678990797	0.649357479769463	1711	Low-affinity Fe(II) transporter of the plasma membrane	intracellular copper ion transport|zinc ion transport|low-affinity iron ion transport|copper ion import	copper ion transmembrane transporter activity|iron ion transmembrane transporter activity	integral to membrane|plasma membrane|integral to plasma membrane
YMR206W_p	YMR206W	hom			0.0078408142089444	0.649782819393123	1712	Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YER154W	OXA1	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.00783502131892196	0.650170422708378	1713	Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals	protein insertion into mitochondrial membrane from inner side|mitochondrial genome maintenance|mitochondrial proton-transporting ATP synthase complex assembly	mitochondrial ribosome binding|membrane insertase activity	mitochondrion|mitochondrial inner boundary membrane|integral to membrane|mitochondrial crista|mitochondrial large ribosomal subunit
YOR198C	BFR1	hom	FT	CELL CYCLE|ENDOMEMBRANE SYSTEM	0.00783110374974049	0.650187613600259	1714	Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity	meiosis|mRNA metabolic process|regulation of mitosis	RNA binding	ribonucleoprotein complex|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YKL135C	APL2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE	0.00781315216205267	0.650936222556829	1715	Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YPR119W	CLB2	hom	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.00777146942386641	0.652675813871808	1716	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|spindle pole body|cellular bud neck|spindle|cytoplasm
YBR284W_p	YBR284W	hom	FT	NUCLEOTIDE METABOLISM	0.00775925593559021	0.653185891138205	1717	Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication	biological_process	AMP deaminase activity|molecular_function	cellular_component
YMR154C	RIM13	hom	FF|FT	ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS	0.0077319716068776	0.654856533501089	1718	Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB	protein processing	cysteine-type endopeptidase activity	cellular_component
YJL124C	LSM1	hom	FF|FT	RNA PROCESSING|NUCLEUS	0.0077029894628106	0.655970584363009	1719	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	RNA binding|RNA cap binding	mRNA cap binding complex|cytoplasmic mRNA processing body|cytoplasm
YNL077W	APJ1	hom	FT	NUCLEUS|MITOCHONDRION	0.00768249216903151	0.656395512153202	1720	Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress	biological_process	unfolded protein binding	mitochondrion|nucleus|cytoplasm
YOR048C	RAT1	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION	0.00767817853276973	0.656719852218973	1721	Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination	termination of RNA polymerase II transcription, exosome-dependent|nuclear mRNA surveillance|termination of RNA polymerase II transcription, poly(A)-coupled|rRNA processing|RNA processing	5'-3' exoribonuclease activity	mitochondrion|nucleus
YDR318W	MCM21	hom	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE	0.00764284870395551	0.658055561735657	1722	Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	COMA complex|condensed nuclear chromosome kinetochore
YHL011C	PRS3	hom	FF|FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM	0.00763361386527839	0.658442508337626	1723	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process|regulation of cell size	ribose phosphate diphosphokinase activity	cytoplasm
YIL004C	BET1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.00762868729709218	0.658648972617734	1724	Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|endoplasmic reticulum membrane|ER to Golgi transport vesicle
YDR315C	IPK1	hom	FT	NUCLEUS	0.00761235135444975	0.659333770871745	1725	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable	nuclear-transcribed mRNA catabolic process, non-stop decay|inositol phosphate biosynthetic process	inositol pentakisphosphate 2-kinase activity	nucleus
YPL086C	ELP3	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION|NUCLEUS	0.00758712665213961	0.660391744162588	1726	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	histone acetyltransferase activity	Elongator holoenzyme complex|nucleus|cytoplasm
YGL133W	ITC1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS	0.00758354656519875	0.660541955064995	1727	Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex	negative regulation of transcription from RNA polymerase II promoter by pheromones|chromatin remodeling|chromatin silencing at telomere	molecular_function	chromatin accessibility complex
YGR101W	PCP1	hom	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00755886400878363	0.661577941092516	1728	Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases	signal peptide processing|regulation of mitochondrion organization	serine-type endopeptidase activity	integral to membrane|mitochondrial inner membrane
YAR003W	SWD1	hom	FT	CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.00755384475733942	0.661788690457063	1729	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7	histone H3-K4 methylation|telomere maintenance|regulation of transcription, DNA-dependent|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YJL056C	ZAP1	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.00755102797015557	0.662096149841724	1730	Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains	regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II regulatory region sequence-specific DNA binding|zinc ion binding	nucleus
YGL161C	YIP5	hom	FT	GOLGI APPARATUS	0.00750506745857799	0.663838154616962	1731	Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YGR273C_p	YGR273C	hom			0.00750013199153743	0.664045667383043	1732	Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene	biological_process	molecular_function	cellular_component
YKR024C	DBP7	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00747211652267394	0.665458555902921	1733	Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus
YPR046W	MCM16	hom	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE	0.00739241440979314	0.668581066454264	1734	Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YCR046C	IMG1	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0073306031653332	0.671419936098906	1735	Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YHR155W	YSP1	hom	FF|FT	MITOCHONDRION	0.00732765435987495	0.671313602588466	1736	Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion
YKL138C	MRPL31	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.00728992256604365	0.673137495335211	1737	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrial large ribosomal subunit
YLR304C	ACO1	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.00728327108412742	0.673188859471374	1738	Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy	propionate metabolic process|glutamate biosynthetic process|tricarboxylic acid cycle|mitochondrial genome maintenance|citrate metabolic process	double-stranded DNA binding|aconitate hydratase activity|single-stranded DNA binding	mitochondrial nucleoid|cytosol|mitochondrion|mitochondrial matrix
YOL108C	INO4	hom	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|NUCLEUS	0.00724025982121758	0.675008086792425	1739	Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain	phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YOR357C	SNX3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00718518816696782	0.677340199570464	1740	Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p	protein localization|late endosome to Golgi transport	phosphatidylinositol-3-phosphate binding	cytosol|endosome
YML036W	CGI121	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|CHROMOSOME	0.0071254783066963	0.680007505369878	1741	Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification	telomere maintenance|positive regulation of transcription from RNA polymerase II promoter	molecular_function	EKC/KEOPS complex
YDR260C	SWM1	hom	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.00710288988449865	0.680831038431927	1742	Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation	ascospore wall assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of mitotic metaphase/anaphase transition|protein ubiquitination	molecular_function	anaphase-promoting complex|nucleus
YBR016W	YBR016W	hom	FT	PLASMA MEMBRANE	0.00709598007493995	0.681124443696799	1743	Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication	biological_process	molecular_function	cellular bud membrane|plasma membrane|mating projection membrane
YOL076W	MDM20	hom	FF|FT	MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION	0.00702848753446321	0.684215804142154	1744	Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly	mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization	peptide alpha-N-acetyltransferase activity	NatB complex
YBL092W	RPL32	het	FF|FT	TRANSLATION|RIBOSOME	0.0070257995091675	0.684419274789594	1745	Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGL218W_d	YGL218W	hom			0.00700833603449657	0.685072588057165	1746	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YNL025C	SSN8	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.00699050906838833	0.6856089311767	1747	Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance	positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter	cyclin-dependent protein kinase regulator activity	mediator complex
YDL154W	MSH5	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.00698437107149674	0.685870253727246	1748	Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans	reciprocal meiotic recombination	molecular_function	nucleus
YDR032C	PST2	hom	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0069510925830706	0.687331888257509	1749	Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|membrane raft|plasma membrane|cytoplasm
YPR134W	MSS18	hom	FT	RNA PROCESSING|MITOCHONDRION	0.0069324993116864	0.688124233613779	1750	Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions	Group I intron splicing	molecular_function	mitochondrion
YOR279C	RFM1	hom	FT	GENE SILENCING|NUCLEUS	0.00692884320469312	0.688236031868947	1751	DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance	chromatin silencing|chromatin silencing at silent mating-type cassette	unfolded protein binding	histone deacetylase complex|nucleus
YCL061C	MRC1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.00692562274804087	0.688373334070554	1752	S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres	maintenance of DNA repeat elements|intra-S DNA damage checkpoint|DNA repair|DNA replication checkpoint|telomere maintenance|replication fork protection|DNA replication|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	molecular_function	nuclear chromosome|replication fork protection complex|nucleus|nuclear replication fork
YOR038C	HIR2	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS	0.00692137090746069	0.688686664737113	1753	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p	DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter	nucleosome binding|transcription corepressor activity|DNA binding	HIR complex|nucleus
YLR119W	SRN2	hom	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT	0.00690200998309548	0.689380363198615	1754	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	protein binding	endosome|ESCRT I complex
YAL033W	POP5	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00689773515650096	0.689562733420167	1755	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YNL130C	CPT1	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS	0.00687112281437771	0.690698459093404	1756	Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication	CDP-choline pathway	diacylglycerol cholinephosphotransferase activity	mitochondrial outer membrane|integral to membrane|Golgi apparatus
YGR258C	RAD2	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|NUCLEUS	0.00684023880253056	0.692017358188847	1757	Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein	nucleotide-excision repair, DNA incision, 3'-to lesion|transcription from RNA polymerase II promoter	single-stranded DNA specific endodeoxyribonuclease activity	nucleotide-excision repair factor 3 complex
YCR069W	CPR4	hom			0.0068380701655111	0.692110004796201	1758	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	membrane
YOR146W_d	YOR146W	het			0.00681733519081249	0.693126426047132	1759	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C	Unknown	Unknown	Unknown
YER167W	BCK2	hom	FT	CELL CYCLE|NUCLEUS	0.00679077404523057	0.694174996822441	1760	Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations	regulation of cell cycle|positive regulation of gene expression|G1/S transition of mitotic cell cycle	molecular_function	nucleus|cytoplasm
YDR118W	APC4	het	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.00677525536551052	0.694795517253233	1761	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YBL079W	NUP170	hom	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.00674368760661393	0.696275753870123	1762	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication	nucleocytoplasmic transport|chromosome segregation|protein targeting to nuclear inner membrane|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YIL107C	PFK26	hom	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.00673959742339676	0.696321704201601	1763	6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YJL081C	ARP4	het	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME|HISTONE ACETYLTRANSFERASE	0.00673091396252337	0.697123700459211	1764	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes	DNA repair|histone acetylation|kinetochore assembly|chromatin organization|regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|chromatin remodeling	chromatin binding|histone acetyltransferase activity|ATP-dependent 3'-5' DNA helicase activity	nuclear chromatin|Swr1 complex|nucleus|Ino80 complex|NuA4 histone acetyltransferase complex
YDL101C	DUN1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS	0.00667772682715055	0.698972727971181	1765	Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair	protein phosphorylation|replication fork protection|cell cycle checkpoint|DNA damage checkpoint	protein kinase activity	nucleus
YLR065C	ENV10	hom	FF|FT	VACUOLAR PROTEIN PROCESSING	0.00665917627266256	0.699981331493638	1766	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene	vacuolar protein processing	molecular_function	integral to membrane
YBR035C	PDX3	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	0.00665777184484274	0.699828541612677	1767	Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism	fatty acid metabolic process	pyridoxamine-phosphate oxidase activity	cellular_component
YIR023W	DAL81	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.00659506728895429	0.702520242002437	1768	Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism	nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process|urea catabolic process	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YHL009C	YAP3	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0065812508436921	0.703113839639906	1769	Basic leucine zipper (bZIP) transcription factor	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YDR475C	JIP4	hom			0.00656676825850333	0.703736250982284	1770	Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence	biological_process	molecular_function	cellular_component
YER161C	SPT2	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION|NUCLEUS	0.00655355194019823	0.70430441575812	1771	Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins	negative regulation of transcription from RNA polymerase II promoter|chromatin organization|RNA polyadenylation|transcription elongation from RNA polymerase II promoter	DNA binding|DNA secondary structure binding	nucleus
YBR243C	ALG7	het	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0065501784812939	0.704449465986714	1772	UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin	protein N-linked glycosylation|aerobic respiration	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity	UDP-N-acetylglucosamine transferase complex|integral to membrane
YPL174C	NIP100	hom	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.00654761687963252	0.704811616835218	1773	Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)	establishment of mitotic spindle orientation	microtubule binding	dynactin complex|cell cortex|spindle pole body|astral microtubule
YKL033W-A_p	YKL033W-A	hom			0.00653262462036853	0.705204411063838	1774	Putative protein of unknown function; similar to uncharacterized proteins from other fungi	biological_process	molecular_function	cellular_component
YBR190W_d	YBR190W	het			0.00650397666281809	0.706437106946881	1775	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W	Unknown	Unknown	Unknown
YKL041W	VPS24	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM	0.0064588612316878	0.7083799437711	1776	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway	intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	molecular_function	ESCRT III complex|cytoplasm
YBR068C	BAP2	hom	FT	PLASMA MEMBRANE	0.00645619681357457	0.708494742928818	1777	High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YHR007C	ERG11	het	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOPLASMIC RETICULUM	0.00645192980237658	0.708678605224598	1778	Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p	ergosterol biosynthetic process	sterol 14-demethylase activity	endoplasmic reticulum
YNL121C	TOM70	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00643689306337705	0.709326662166617	1779	Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication	protein import into mitochondrial matrix|protein import into mitochondrial inner membrane	mitochondrion targeting sequence binding|protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YOR340C	RPA43	het	FF|FT	NUCLEUS	0.00643071599583973	0.709592943851302	1780	RNA polymerase I subunit A43	transcription of nuclear large rRNA transcript from RNA polymerase I promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase I complex
YDR525W_d	API2	hom			0.00641289837945208	0.710526224219853	1781	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology	Unknown	Unknown	Unknown
YHR026W	VMA16	hom	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.00640565166646157	0.710797400669495	1782	Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YMR105W-A_p	YMR105W-A	hom			0.0063963924739453	0.711073211013325	1783	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR064W	AEP1	hom	FT	TRANSLATION|MITOCHONDRION	0.0063843709145586	0.711591921575341	1784	Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase	regulation of translation	translation regulator activity	mitochondrion
YGL020C	GET1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS	0.00637187941581803	0.712131050643973	1785	Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance	retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane	protein anchor	mitochondrion|integral to membrane|endoplasmic reticulum|GET complex
YPL025C_d	YPL025C	hom			0.00633367699715802	0.713780746485064	1786	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL183C	RTT10	hom	FT	VESICLE-MEDIATED TRANSPORT	0.00628436984565437	0.716033546209381	1787	WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6	endocytic recycling	molecular_function	endosome|cytoplasm
YLR148W	PEP3	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	0.0062801082497042	0.716298825027668	1788	Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|vacuole fusion, non-autophagic|late endosome to vacuole transport|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol binding|protein binding, bridging	fungal-type vacuole membrane|HOPS complex|proteasome storage granule|CORVET complex|extrinsic to vacuolar membrane
YDR162C	NBP2	hom	FF|FT	PROTEIN PHOSPHORYLATION|NUCLEUS	0.0062471538689332	0.717885092404267	1789	Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)	negative regulation of protein kinase activity|response to heat|hyperosmotic response	molecular_function	nucleus|cytoplasm
YOL115W	PAP2	hom	FT	CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION|NUCLEUS	0.00621567031336584	0.718885054520341	1790	Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p	polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|base-excision repair|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U4 snRNA 3'-end processing|nuclear mRNA surveillance of mRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation|tRNA modification	5'-deoxyribose-5-phosphate lyase activity|polynucleotide adenylyltransferase activity	nucleolus|nucleus|TRAMP complex
YLR169W_d	YLR169W	hom			0.00618839606982764	0.720066580807607	1791	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR122W	YGR122W	hom	FF|FT	TRANSCRIPTION FROM RNA POL II	0.00616363349948223	0.721139880069429	1792	Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	cytoplasm
YBR289W	SNF5	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|CHROMOSOME|RSC COMPLEX	0.00614929119475352	0.721761778692645	1793	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions	sucrose catabolic process|double-strand break repair via homologous recombination|chromatin remodeling|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding	SWI/SNF complex|nucleus
YHL025W	SNF6	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|NUCLEUS|RSC COMPLEX	0.00614736177119013	0.721845454730776	1794	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions	sucrose catabolic process|nucleotide-excision repair|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex|nucleus
YJR059W	PTK2	hom	FF|FT	CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|NUCLEUS|PLASMA MEMBRANE	0.00613072467865942	0.722567116964804	1795	Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake	protein phosphorylation|cellular ion homeostasis|polyamine transport|G1/S transition of mitotic cell cycle|regulation of cell size	protein kinase activity	nucleus|plasma membrane|cytoplasm
YDR295C	HDA2	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.00612488245424347	0.722820591978196	1796	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance	negative regulation of transcription from RNA polymerase II promoter|gene silencing by RNA|histone deacetylation|gene silencing involved in chronological cell aging	histone deacetylase activity|chromatin binding|DNA binding	nucleus|HDA1 complex
YML042W	CAT2	hom	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.00611046804390676	0.723446116112104	1797	Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes	carnitine metabolic process	carnitine O-acetyltransferase activity	mitochondrion|peroxisomal matrix|peroxisome
YKR073C_d	YKR073C	hom			0.00605840925674585	0.725706781623779	1798	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL043C	CBR1	hom	FT	OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.00603657690847428	0.726655569429425	1799	Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia	biological_process	cytochrome-b5 reductase activity	mitochondrial outer membrane|mitochondrion
YPL238C_d	YPL238C	het	FF		0.00603559277689377	0.726815725763977	1800	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W	Unknown	Unknown	Unknown
YCR003W	MRPL32	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.00600349226381284	0.728094156924007	1801	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit
YDR268W	MSW1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00599831491705547	0.728319365287204	1802	Mitochondrial tryptophanyl-tRNA synthetase	mitochondrial tryptophanyl-tRNA aminoacylation	tryptophan-tRNA ligase activity	mitochondrion
YGL026C	TRP5	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.00599177401460603	0.728603920203585	1803	Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis	tryptophan biosynthetic process	tryptophan synthase activity	nucleus|cytoplasm
YHR176W	FMO1	hom	FT	OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00596489287532749	0.729773747364277	1804	Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins	protein folding	N,N-dimethylaniline monooxygenase activity	endoplasmic reticulum membrane
YLR382C	NAM2	hom	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00591401253410238	0.732451226575524	1805	Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance	Group I intron splicing|leucyl-tRNA aminoacylation|mitochondrial translation	mRNA binding|leucine-tRNA ligase activity	mitochondrion
YPR129W	SCD6	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	0.00589571740517352	0.732787046569282	1806	Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress	stress granule assembly|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly	mRNA binding|RNA binding|eukaryotic initiation factor 4G binding	cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YLR310C	CDC25	het	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEUS|PLASMA MEMBRANE	0.00584110501179332	0.735320950075606	1807	Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1	regulation of cell cycle|replicative cell aging|Ras protein signal transduction|traversing start control point of mitotic cell cycle	Ras guanyl-nucleotide exchange factor activity	cytosol|nucleus|plasma membrane|cytoplasm
YBR246W	RRT2	hom	FT	VESICLE-MEDIATED TRANSPORT	0.00583876926137158	0.735308808678192	1808	Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription	peptidyl-diphthamide biosynthetic process from peptidyl-histidine|endocytic recycling	molecular_function	endosome|cytoplasm
YDL147W	RPN5	het	FT	PROTEOLYSIS|NUCLEUS	0.00580649599085412	0.736679632900193	1809	Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein	cullin deneddylation|ubiquitin-dependent protein catabolic process	molecular_function	proteasome complex|signalosome|proteasome storage granule|proteasome regulatory particle, lid subcomplex
YNL231C	PDR16	hom	FF|FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00579894375844771	0.737160524277879	1810	Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress	response to drug|sterol biosynthetic process|phospholipid biosynthetic process|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cell periphery|lipid particle|plasma membrane|cytoplasm
YLR029C	RPL15A	het	FT	TRANSLATION|RIBOSOME	0.00579627783296648	0.737125868174673	1811	Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YML123C	PHO84	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.00578814395389065	0.73751884476228	1812	High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity	phosphate ion transport|manganese ion transport|polyphosphate metabolic process	manganese ion transmembrane transporter activity|inorganic phosphate transmembrane transporter activity	integral to membrane|integral to plasma membrane
YGR196C	FYV8	hom			0.005776922145814	0.737971389556761	1813	Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	cytoplasm
YJL159W	HSP150	hom	FT	CELL WALL ORG/BIOGENESIS	0.00574166426184917	0.739512386197231	1814	O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication	fungal-type cell wall organization	structural constituent of cell wall|ATPase activity	fungal-type cell wall|extracellular region
YMR052W	FAR3	hom	FT	CELL CYCLE|SIGNALING|ENDOPLASMIC RETICULUM	0.00571340349495782	0.740748319296251	1815	Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	endoplasmic reticulum
YOL087C	DUF1	hom			0.00564254610841992	0.743850073399053	1816	Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid	biological_process	ubiquitin binding	cytoplasm
YKL104C	GFA1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.00545520147919921	0.75217820926936	1817	Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication	fungal-type cell wall chitin biosynthetic process	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	cellular_component
YBL038W	MRPL16	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.00541017568897182	0.754050936452528	1818	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome|peptidyltransferase activity	mitochondrion|mitochondrial large ribosomal subunit
YDR462W	MRPL28	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.00540030038314691	0.754485420015548	1819	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YMR256C	COX7	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.00539856222777203	0.754774511490525	1820	Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YGR106C	VOA1	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00538487162529553	0.755341148896412	1821	Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval	protein complex assembly	molecular_function	fungal-type vacuole membrane|endoplasmic reticulum membrane
YIL030C	SSM4	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX	0.00537698957769628	0.755511332752831	1822	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation	ER-associated protein catabolic process	ubiquitin-protein ligase activity	nuclear envelope|integral to endoplasmic reticulum membrane|Doa10p ubiquitin ligase complex|integral to membrane|nuclear inner membrane
YOR330C	MIP1	hom	FT	MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00537347004852022	0.755842682169918	1823	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit	mitochondrial DNA replication	3'-5' exonuclease activity|DNA-directed DNA polymerase activity	mitochondrion
YHL019C	APM2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00535409420778447	0.756519381786665	1824	Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YHR073W	OSH3	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOPLASMIC RETICULUM	0.0053243086787383	0.757831414112664	1825	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	karyogamy involved in conjugation with cellular fusion|endocytosis|exocytosis|positive regulation of phosphatase activity|maintenance of cell polarity|pseudohyphal growth|sterol transport|invasive growth in response to glucose limitation	lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity	cortical endoplasmic reticulum|cytoplasm
YDR172W	SUP35	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEOTIDE METABOLISM	0.00531262842265686	0.758346112090756	1826	Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype	translational termination|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	translation release factor activity	cytosol|translation release factor complex
YHL004W	MRP4	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.00529113848815004	0.759293359406782	1827	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome|tRNA binding	mitochondrion|mitochondrial small ribosomal subunit
YDR320C	SWA2	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00528382073466979	0.759615998592788	1828	Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles	positive regulation of ATPase activity|endoplasmic reticulum inheritance|clathrin coat disassembly	ubiquitin binding|clathrin binding	endoplasmic reticulum membrane
YPL212C	PUS1	hom	FT	RNA PROCESSING|NUCLEUS	0.00528031793601654	0.759770451518375	1829	tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA	snRNA pseudouridine synthesis|tRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus
YJR118C	ILM1	hom	FF|FT	MITOCHONDRION ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00523865160449119	0.761608425801187	1830	Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth	mitochondrial genome maintenance	molecular_function	integral to membrane|endoplasmic reticulum
YGR037C	ACB1	hom	FF|FT	KETONE METABOLISM|LIPID METABOLISM|NUCLEUS	0.00520921108645756	0.76290790988202	1831	Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress	long-chain fatty acid transport|chronological cell aging|fatty acid metabolic process	long-chain fatty acid transporter activity|fatty-acyl-CoA binding	extracellular region|nucleus|cytoplasm
YDR326C	YSP2	hom	FT	MITOCHONDRION	0.00520646588032144	0.763029115492019	1832	Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication	apoptotic process	molecular_function	mitochondrion
YPL057C	SUR1	hom	FT	LIPID METABOLISM	0.00518023108580992	0.764187719679126	1833	Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication	glycosphingolipid biosynthetic process|mannosyl-inositol phosphorylceramide metabolic process|sphingolipid biosynthetic process	mannosyltransferase activity|transferase activity, transferring glycosyl groups	integral to membrane|intracellular
YGL011C	SCL1	het	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	0.0051711683721191	0.764588078061626	1834	Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|nucleus|proteasome storage granule|nuclear outer membrane-endoplasmic reticulum membrane network
YBL078C	ATG8	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|ENDOMEMBRANE SYSTEM	0.00512155579605252	0.766780896819654	1835	Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose &#65532;conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis	piecemeal microautophagy of nucleus|mitochondrion degradation|cellular membrane fusion|ER to Golgi vesicle-mediated transport|CVT pathway|autophagic vacuole assembly	molecular_function	cytosol|fungal-type vacuole membrane|pre-autophagosomal structure|extrinsic to membrane|autophagic vacuole
YMR079W	SEC14	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00511849435480747	0.766916270375715	1836	Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs	Golgi vesicle budding|phosphatidylinositol metabolic process|Golgi to plasma membrane protein transport|Golgi to vacuole transport|ascospore formation|Unknown|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cytosol|Golgi apparatus|Golgi membrane|cytoplasm
YOR054C	VHS3	hom	FT	CELL CYCLE|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM	0.00511562519439969	0.767043147940313	1837	Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis	coenzyme A biosynthetic process|cellular monovalent inorganic cation homeostasis	phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity	phosphopantothenoylcysteine decarboxylase complex
YHR080C	YHR080C	hom	FT	MITOCHONDRION	0.00510202989882683	0.767678082398901	1838	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|ribosome
YDR238C	SEC26	het	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00509243639687604	0.768068812000721	1839	Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)	ER to Golgi vesicle-mediated transport	molecular_function	coated vesicle|COPI vesicle coat
YNL170W_d	YNL170W	hom			0.00508904812844759	0.768218712596326	1840	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR143W	RRP15	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00505784530176831	0.769599565429906	1841	Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YOR256C	TRE2	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	0.00503083816763135	0.770795331761495	1842	Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	molecular_function	cellular_component
YBL104C	SEA4	hom			0.00502966386906371	0.770847337314881	1843	Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites	biological_process	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane|cytoplasm
YMR033W	ARP9	het	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RSC COMPLEX	0.00500720409529932	0.771875277386424	1844	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation	nucleosome positioning|ATP-dependent chromatin remodeling|nucleosome mobilization|chromatin organization|nucleosome disassembly|transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	DNA translocase activity	RSC complex|SWI/SNF complex|nucleus
YEL063C	CAN1	hom	FT	MITOCHONDRION|PLASMA MEMBRANE	0.00499913099971919	0.772265954655845	1845	Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity	mitochondrion|integral to membrane|membrane raft|plasma membrane
YBR291C	CTP1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.00498218444496644	0.772950894016713	1846	Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family	mitochondrial citrate transport|transmembrane transport	tricarboxylate secondary active transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDL226C	GCS1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|MITOCHONDRION|GOLGI APPARATUS|CYTOSKELETON	0.00493081943848006	0.775228478506434	1847	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p	retrograde vesicle-mediated transport, Golgi to ER|Golgi to plasma membrane protein transport|actin filament reorganization involved in cell cycle|ER to Golgi vesicle-mediated transport	actin binding|ARF GTPase activator activity|GTPase activator activity	endosome|trans-Golgi network|endoplasmic reticulum-Golgi intermediate compartment|cytoskeleton
YAL026C	DRS2	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS|GOLGI APPARATUS	0.0049229668932794	0.775609407411162	1848	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease	intracellular protein transport|post-Golgi vesicle-mediated transport|phospholipid translocation|endocytosis|ribosomal small subunit assembly	phospholipid-translocating ATPase activity	trans-Golgi network|integral to membrane
YML062C	MFT1	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION|NUCLEUS	0.00479671827818528	0.781470109722023	1849	Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance	mRNA export from nucleus|DNA recombination|transcription elongation from RNA polymerase II promoter	protein complex scaffold|nucleic acid binding	THO complex part of transcription export complex|nucleoplasmic THO complex
YJL105W	SET4	hom	FT	CHROMATIN ORGANIZATION	0.00478642184248301	0.781673273958943	1850	Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YML097C	VPS9	hom	FF|FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	0.00477737844206324	0.782043679360981	1851	A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin	vacuole inheritance|protein targeting to vacuole	ubiquitin binding|guanyl-nucleotide exchange factor activity	cytosol
YKR042W	UTH1	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|GENE SILENCING|MITOCHONDRION	0.00477566622719928	0.782119824230295	1852	Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication	mitochondrion degradation|fungal-type cell wall biogenesis|negative regulation of chromatin silencing involved in replicative cell aging	molecular_function	mitochondrial outer membrane|fungal-type cell wall
YNR003C	RPC34	het	FT	NUCLEUS|MITOCHONDRION	0.00472453819627665	0.784394526235894	1853	RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	mitochondrion|DNA-directed RNA polymerase III complex|nucleus|cytoplasm
YML092C	PRE8	het	FF|FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	0.00467501154181315	0.786692905298065	1854	Alpha 2 subunit of the 20S proteasome	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YER031C	YPT31	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS	0.00464565510038465	0.787938537095116	1855	Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication	early endosome to Golgi transport|vesicle-mediated transport|exocytosis	GTPase activity	mitochondrial outer membrane|endosome|Golgi apparatus
YJL024C	APS3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00459754754248981	0.790052312361689	1856	Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress	Golgi to vacuole transport|vesicle-mediated transport	molecular_function	AP-3 adaptor complex
YKL167C	MRP49	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.00459605951512423	0.790118674364324	1857	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YJR113C	RSM7	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.00457782229554148	0.791145385006601	1858	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YFR009W	GCN20	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEOTIDE METABOLISM|RIBOSOME	0.00451107186159494	0.794061638403198	1859	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA	regulation of translational elongation	ATPase activity	cytosol|cytosolic ribosome
YMR013C	SEC59	het	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00445074778067328	0.796606442590275	1860	Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation	protein glycosylation	dolichol kinase activity	integral to membrane|endoplasmic reticulum membrane
YML017W	PSP2	hom			0.00440697879892869	0.798563385785054	1861	Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing	biological_process	molecular_function	cytoplasm
YPR123C_d	YPR123C	hom	FF		0.00434057920091162	0.801621512207045	1862	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR	Unknown	Unknown	Unknown
YER086W	ILV1	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.00433583004129099	0.801747194588949	1863	Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation	threonine catabolic process|isoleucine biosynthetic process	L-threonine ammonia-lyase activity	mitochondrion
YDL190C	UFD2	hom	FT	PROTEOLYSIS|NUCLEUS	0.00433200676248732	0.80200515298797	1864	Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3	ER-associated protein catabolic process|protein ubiquitination|ubiquitin-dependent protein catabolic process|response to stress	ubiquitin-ubiquitin ligase activity	nucleus|cytoplasm
YPR124W	CTR1	hom	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.00433195286230204	0.801920788103792	1865	High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress	copper ion import	copper uptake transmembrane transporter activity	integral to membrane|plasma membrane
YBL049W	MOH1	hom			0.00431781042137836	0.802554072510338	1866	Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase	biological_process	molecular_function	cellular_component
YKL028W	TFA1	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION|RNA POL II, HOLOENZYME	0.00431650082118723	0.802612721665769	1867	TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening	transcriptional open complex formation at RNA polymerase II promoter|transcription from RNA polymerase II promoter	single-stranded DNA binding|TFIIH-class transcription factor binding|RNA polymerase II core binding	mitochondrion|transcription factor TFIIE complex
YHL039W	EFM1	hom			0.00431576600032355	0.802645630381571	1868	Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	cytoplasm
YJL119C_d	YJL119C	hom			0.00425740717307982	0.805260324175468	1869	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR279C	YMR279C	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.00424658400454809	0.805745482934887	1870	Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication	borate transmembrane transport	borate efflux transmembrane transporter activity	integral to membrane
YNL147W	LSM7	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00423588343254204	0.806225219676607	1871	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasm
YBR255W	MTC4	hom			0.00420286915289198	0.807705801332109	1872	Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1	biological_process	molecular_function	cytoplasm
YHR004C	NEM1	hom	FF|FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.00411297485633245	0.811961217993653	1873	Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|mitochondrion|integral to membrane
YDR120C	TRM1	hom	FT	RNA PROCESSING|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	0.00411051711858531	0.811851127901928	1874	tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments	tRNA methylation	tRNA (guanine-N2-)-methyltransferase activity	mitochondrion|nuclear envelope|nuclear inner membrane
YNL296W_d	YNL296W	hom			0.00406650427646217	0.813828558626943	1875	Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog	Unknown	Unknown	Unknown
YNL184C_p	YNL184C	hom			0.00406569172639982	0.813865076471595	1876	Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YOR358W	HAP5	hom	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.00405004947894453	0.814568153321689	1877	Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex
YDR207C	UME6	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|CHROMOSOME	0.00400458581338025	0.816693055393487	1878	Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p	spore germination|positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter during meiosis|lipid particle organization|nitrogen catabolite repression of transcription from RNA polymerase II promoter|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|repressing transcription factor binding|transcription factor binding transcription factor activity	Rpd3L-Expanded complex|Rpd3L complex
YGL007W_d	BRP1	hom	FF		0.00399948707953791	0.816841815505097	1879	Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1	Unknown	Unknown	Unknown
YOR260W	GCD1	het	FT	TRANSLATION	0.00398135411088793	0.817684296090284	1880	Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression	regulation of translational initiation	translation initiation factor activity|guanyl-nucleotide exchange factor activity	eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YFL002C	SPB4	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00392508830887414	0.820190136564943	1881	Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients	ribosomal large subunit assembly|rRNA processing	ATP-dependent RNA helicase activity	nucleolus|90S preribosome
YMR301C	ATM1	het	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION	0.00388171461852396	0.822169765364506	1882	Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol	cellular iron ion homeostasis	ATPase activity, coupled to transmembrane movement of substances|ATPase activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YBR036C	CSG2	hom	FF|FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00388150966686617	0.822152922615603	1883	Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress	cellular calcium ion homeostasis|glycosphingolipid biosynthetic process	enzyme regulator activity	integral to endoplasmic reticulum membrane|integral to membrane
YKL194C	MST1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00375338557370911	0.827930046863754	1884	Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro	mitochondrial threonyl-tRNA aminoacylation	threonine-tRNA ligase activity	mitochondrion
YNL255C	GIS2	hom	FT	TRANSLATION|RIBOSOME	0.00374911966263979	0.828122559094437	1885	Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2	positive regulation of translation	mRNA binding|translation regulator activity|single-stranded DNA binding	polysomal ribosome|cytoplasm
YDR008C_d	YDR008C	hom	FF		0.0037345434086497	0.829132681493975	1886	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR220C_p	YBR220C	hom			0.00369720539115193	0.830491067648464	1887	Putative protein of unknown function; YBR220C is not an essential gene	biological_process	molecular_function	integral to membrane
YMR077C	VPS20	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT	0.00369339257839894	0.830712981191579	1888	Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes	intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	protein binding	ESCRT III complex|cytoplasm
YER127W	LCP5	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00363427707844601	0.833309023071112	1889	Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus	rRNA modification|rRNA processing	RNA binding	small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex
YPL049C	DIG1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0036041726062215	0.834669796460848	1890	MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p	negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown	DNA binding|transcription factor binding	nucleus
YNL298W	CLA4	hom	FF|FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.00356588170296998	0.836690164638891	1891	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p	negative regulation of gene expression|vacuole inheritance|protein phosphorylation|budding cell apical bud growth|Rho protein signal transduction|regulation of exit from mitosis|establishment of cell polarity|sterol import|response to pheromone|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	nucleus|cellular bud|fungal-type vacuole
YGL175C	SAE2	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.0035634518332909	0.836631437322504	1892	Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents	DNA double-strand break processing|DNA catabolic process, endonucleolytic|meiotic DNA double-strand break formation|meiotic DNA double-strand break processing|gene conversion at mating-type locus, DNA double-strand break processing	double-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity	nucleus|cytoplasm
YBL050W	SEC17	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	0.00355744124656437	0.836783112620902	1893	Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP	autophagy|SNARE complex disassembly|vesicle fusion with Golgi apparatus|vacuole fusion, non-autophagic	ATPase activator activity|soluble NSF attachment protein activity	SNARE complex|cytosol|extrinsic to membrane
YBR023C	CHS3	hom	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH	0.00353517462951843	0.837790483440079	1894	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan	ascospore wall assembly|fungal-type cell wall chitin biosynthetic process|cytokinesis	chitin synthase activity	incipient cellular bud site|integral to membrane|chitosome|prospore membrane|cellular bud neck|mating projection tip|cytoplasm
YDR372C	VPS74	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS	0.00352258666507073	0.838478981983016	1895	Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33	retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum unfolded protein response|protein localization to Golgi apparatus	enzyme binding|phosphatidylinositol-4-phosphate binding	cytosol|Golgi apparatus|nucleus|extrinsic to membrane|cytoplasm
YAL001C	TFC3	het	FF|FT	PROTEIN LOCALIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.00351180826752489	0.838847893987226	1896	Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding	protein localization to chromatin|transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter	RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending	transcription factor TFIIIC complex|mitochondrion|nuclear condensin complex
YGL181W	GTS1	hom	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM|NUCLEUS|CYTOSKELETON	0.00349415080951447	0.839647149500691	1897	Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations	endocytosis|ultradian rhythm|regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylinositol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	ARF GTPase activator activity|repressing transcription factor binding|transcription factor binding transcription factor activity	nucleus|cytoplasm|actin cortical patch
YDL145C	COP1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00348770088444098	0.839939143217671	1898	Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport	ubiquitin binding	COPI vesicle coat
YNL110C	NOP15	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS	0.00341133671456314	0.843490094609131	1899	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm	cytokinesis, actomyosin contractile ring assembly|ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YDL196W_d	YDL196W	het	FF		0.00337974654716705	0.844898108888366	1900	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31	Unknown	Unknown	Unknown
YNL052W	COX5A	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0033244357374596	0.847337525586062	1901	Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YJL129C	TRK1	hom	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.0033221593024668	0.847440779262655	1902	Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication	cellular potassium ion homeostasis	potassium ion transmembrane transporter activity	membrane raft|integral to membrane|plasma membrane
YBR179C	FZO1	hom	FT	MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00329980083419083	0.848522024640032	1903	Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system	mitochondrial fusion	GTPase activity|protein homodimerization activity	mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YGL033W	HOP2	hom	FF|FT	CELL CYCLE|NUCLEUS|CHROMOSOME	0.003292794560374	0.848772928160448	1904	Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair	synapsis|reciprocal meiotic recombination	protein binding|double-stranded DNA binding	condensed nuclear chromosome
YJR047C	ANB1	hom	FT	KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|TRANSLATION|RIBOSOME	0.00328404865249897	0.849169775075858	1905	Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication	translational frameshifting|positive regulation of translational termination|positive regulation of translational elongation	ribosome binding|RNA binding|translation elongation factor activity	cytosolic ribosome
YDL192W	ARF1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS|GOLGI APPARATUS	0.00326577293559579	0.850065475492396	1906	ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|intra-Golgi vesicle-mediated transport|macroautophagy	GTPase activity	cytosol|Golgi-associated vesicle
YMR070W	MOT3	hom	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|NUCLEUS	0.00326192492049758	0.850173813171652	1907	Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion	cellular hyperosmotic response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ergosterol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	nucleus
YNL084C	END3	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON	0.00324811577779881	0.850800634704931	1908	EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p	bipolar cellular bud site selection|ascospore wall assembly|endocytosis|actin filament organization|cytokinesis|actin cortical patch assembly	protein binding, bridging	mating projection tip|actin cortical patch
YBR015C	MNN2	hom	FF|FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00323529851580842	0.851382517356895	1909	Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment	protein glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YHR036W	BRL1	het	FF|FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0031915921423013	0.85336732128031	1910	Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export	mRNA export from nucleus|protein export from nucleus|nuclear envelope organization	molecular_function	nuclear envelope|endoplasmic reticulum
YLR052W	IES3	hom	FT	CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.00319152488750444	0.853413611623415	1911	Subunit of the INO80 chromatin remodeling complex	nucleosome mobilization|telomere maintenance|chromatin silencing at telomere	molecular_function	nucleus|Ino80 complex
YHR143W-A	RPC10	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.00318472011438563	0.853679480164268	1912	RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress	transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YLL041C	SDH2	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.00308876848328453	0.858145157894263	1913	Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain	mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial membrane
YJR063W	RPA12	hom	FF|FT	NUCLEUS	0.00308594557868648	0.858168777237365	1914	RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex	termination of RNA polymerase I transcription|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	molecular_function	DNA-directed RNA polymerase I complex
YDR292C	SRP101	het	FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00308044959264981	0.858418705587976	1915	Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p	SRP-dependent cotranslational protein targeting to membrane|protein targeting to ER	GTP binding|signal recognition particle binding	endoplasmic reticulum membrane|signal recognition particle receptor complex
YJR134C	SGM1	hom	FT	GOLGI APPARATUS	0.00307673108578156	0.85858781164181	1916	Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus	biological_process	molecular_function	COPI-coated vesicle|Golgi apparatus
YDR353W	TRR1	het	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	0.00303709369701371	0.860390797516721	1917	Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication	cellular response to oxidative stress|cell redox homeostasis	ferrous iron binding|thioredoxin-disulfide reductase activity	cytosol
YGR287C	IMA1	hom	FT	CARBOHYDRATE METABOLISM|MITOCHONDRION	0.00303147600876689	0.860646388386759	1918	Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family	disaccharide catabolic process	oligo-1,6-glucosidase activity	mitochondrion|ribosome
YJL053W	PEP8	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM	0.00302227220034051	0.861065170345758	1919	Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YDL143W	CCT4	het	FF		0.00300964706120045	0.861639689575532	1920	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	protein folding	unfolded protein binding	chaperonin-containing T-complex
YGL099W	LSG1	het	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|SITE OF POLARIZED GROWTH	0.00300549797912815	0.861828513579784	1921	Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm	conjugation with cellular fusion|ribosomal large subunit assembly|ribosomal subunit export from nucleus|ascospore formation	GTPase activity	mating projection tip|cytoplasm
YHR017W	YSC83	hom	FT	MITOCHONDRION	0.00297950828856457	0.863072161485499	1922	Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YHR041C	SRB2	hom	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|RNA POL II, HOLOENZYME	0.00290829690922347	0.866254353181383	1923	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding	core mediator complex
YJL047C	RTT101	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.00289457838636693	0.866899001670998	1924	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p	replication fork processing|negative regulation of transposition, RNA-mediated|regulation of mitosis|nonfunctional rRNA decay|ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	Cul8-RING ubiquitin ligase complex|nucleus|cytoplasm
YMR001C-A_p	YMR001C-A	hom			0.00288743904417831	0.867204622195624	1925	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPR174C	YPR174C	hom	FT	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON	0.00281432459513069	0.870537168917895	1926	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication	biological_process	molecular_function	nuclear envelope|spindle pole body
YAL047C	SPC72	hom	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CYTOSKELETON	0.00280300234241649	0.871053442740894	1927	Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization	microtubule nucleation|nuclear migration along microtubule|mitotic cell cycle spindle orientation checkpoint|mitotic spindle elongation|mitotic sister chromatid segregation	structural constituent of cytoskeleton	outer plaque of spindle pole body
YGR116W	SPT6	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RNA LOCALIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.00279981301689508	0.871198880021361	1928	Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region	poly(A)+ mRNA export from nucleus|regulation of transcription by chromatin organization|regulation of mRNA 3'-end processing|transcription antitermination|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|regulation of transcriptional start site selection at RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of transcription from RNA polymerase II promoter|nucleosome organization|chromatin maintenance|regulation of nucleosome density|nucleosome assembly|chromatin remodeling|regulation of histone H3-K36 methylation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to stress	core RNA polymerase II binding transcription factor activity|nucleosome binding|histone binding|DNA binding transcription antitermination factor activity	mitochondrion|nucleus|transcriptionally active chromatin
YNL243W	SLA2	hom	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON	0.00275965941204199	0.873030306047935	1929	Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo	bipolar cellular bud site selection|fungal-type cell wall organization|actin filament organization|endocytosis|exocytosis	protein binding, bridging	incipient cellular bud site|mating projection tip|actin cortical patch
YMR277W	FCP1	het	FF|FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.00272293792378679	0.874724315607124	1930	Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)	dephosphorylation of RNA polymerase II C-terminal domain|regulation of transcription from RNA polymerase II promoter	protein serine/threonine phosphatase activity	nucleus
YKR072C	SIS2	hom	FF|FT	CELL CYCLE|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.00270710349849474	0.875502143527979	1931	Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis	regulation of mitotic cell cycle|response to salt stress|coenzyme A biosynthetic process	phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity	phosphopantothenoylcysteine decarboxylase complex|nucleus|cytoplasm
YLR417W	VPS36	hom	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.00264934056495298	0.87811960388328	1932	Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome	negative regulation of transcription from RNA polymerase II promoter by glucose|protein retention in Golgi apparatus|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	ubiquitin binding	ESCRT II complex
YMR203W	TOM40	het	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.00262009946613401	0.879508045200826	1933	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore	protein import into mitochondrial matrix	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YML057W	CMP2	hom	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS	0.00260619234444745	0.880036201820766	1934	Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity	calcineurin complex|cytoplasm
YDR452W	PPN1	hom	FT	NUCLEUS	0.002478135963258	0.885889295501128	1935	Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress	polyphosphate catabolic process|polyphosphate metabolic process	endopolyphosphatase activity|exopolyphosphatase activity	fungal-type vacuole membrane|nucleus
YPR145W	ASN1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.00243329711600052	0.887940240567244	1936	Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication	asparagine biosynthetic process	asparagine synthase (glutamine-hydrolyzing) activity	cytoplasm
YGR093W_p	YGR093W	hom	FT	NUCLEUS	0.00242700984767581	0.888227882774311	1937	Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	biological_process	molecular_function	nucleus
YKL039W	PTM1	hom	FT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00242311363279312	0.888406141793973	1938	Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YER119C-A_d	YER119C-A	hom	FF		0.00241678170467881	0.888695851217769	1939	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2	Unknown	Unknown	Unknown
YKL212W	SAC1	hom	FF|FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS	0.00235979317810124	0.891303953923286	1940	Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|mitochondrion|SPOTS complex|integral to Golgi membrane
YJL120W_d	YJL120W	hom	FF		0.00234239475190856	0.892100435451294	1941	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YOR376W-A_p	YOR376W-A	hom			0.00233440826989067	0.892466084627851	1942	Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YNL178W	RPS3	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME	0.00230171938108126	0.893962934040458	1943	Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome|DNA-(apurinic or apyrimidinic site) lyase activity	preribosome, small subunit precursor|cytosolic small ribosomal subunit|90S preribosome
YOL001W	PHO80	hom	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.00229159982073267	0.894426393287553	1944	Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling	negative regulation of phosphate metabolic process|regulation of cyclin-dependent protein kinase activity|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|cellular metal ion homeostasis|regulation of protein localization|negative regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YIR033W	MGA2	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.00225641024541817	0.8960382975157	1945	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	molecular_function	integral to endoplasmic reticulum membrane|nucleus
YBR283C	SSH1	hom	FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00223718365305647	0.896919178247357	1946	Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential	SRP-dependent cotranslational protein targeting to membrane	protein transmembrane transporter activity|signal sequence binding	integral to membrane|Ssh1 translocon complex
YLR099C	ICT1	hom	FT	KETONE METABOLISM|LIPID METABOLISM	0.00219282965121127	0.898951772769541	1947	Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication	phosphatidic acid biosynthetic process	lysophosphatidic acid acyltransferase activity	cellular_component
YGR036C	CAX4	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00215031490695645	0.900900702599862	1948	Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation	lipid biosynthetic process|protein N-linked glycosylation	dolichyldiphosphatase activity	integral to endoplasmic reticulum membrane|integral to membrane
YGR020C	VMA7	hom	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.00214939536067232	0.900942862409822	1949	Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YKL033W	TTI1	het	FT	CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.00210490253665904	0.902997517379669	1950	Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	ASTRA complex|mitochondrion|cytoplasm
YLR200W	YKE2	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEUS	0.00210057356655185	0.90318166618414	1951	Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin	protein folding|tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YBL036C	YBL036C	hom			0.00208185823599625	0.904040093544055	1952	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS	biological_process	pyridoxal phosphate binding	cellular_component
YER048W-A	ISD11	het	FT	COFACTOR METABOLISM|MITOCHONDRION	0.00201502474193621	0.907106493897104	1953	Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis	iron-sulfur cluster assembly	enzyme activator activity	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YIL128W	MET18	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE|NUCLEUS	0.0020079128558853	0.907474105790043	1954	Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19	methionine metabolic process|nucleotide-excision repair|transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YHR170W	NMD3	het	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS|RIBOSOME	0.00197766662734299	0.908983705349526	1955	Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex	ribosomal large subunit export from nucleus	ribosomal large subunit binding	cytosol|cytosolic large ribosomal subunit
YNL220W	ADE12	hom	FT	NUCLEOTIDE METABOLISM	0.00194259813352729	0.910431074769767	1956	Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence	purine nucleotide biosynthetic process	DNA replication origin binding|adenylosuccinate synthase activity	cytoplasm
YCR030C	SYP1	hom	FT	CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH	0.00193922882090427	0.910585774124444	1957	Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization	septin cytoskeleton organization|actin cortical patch assembly	molecular_function	mating projection base|mating projection tip|cellular bud neck|cellular bud tip
YER106W	MAM1	hom	FT	CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE	0.00193833127388242	0.910626984865923	1958	Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle	meiotic chromosome segregation|meiotic sister chromatid cohesion involved in meiosis I	molecular_function	condensed nuclear chromosome kinetochore|monopolin complex
YBR265W	TSC10	het	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.00193013956275222	0.911003117188052	1959	3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family	3-keto-sphinganine metabolic process|sphingolipid biosynthetic process	oxidoreductase activity, acting on NADH or NADPH	mitochondrial outer membrane|endoplasmic reticulum|cytoplasm
YMR041C	ARA2	hom	FT	OXIDATION-REDUCTION PROCESS	0.00190136182629215	0.912324639232052	1960	NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase	dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinose 1-dehydrogenase [NAD(P)+] activity	cellular_component
YDR303C	RSC3	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS|RSC COMPLEX	0.00189342613545118	0.913065936451219	1961	Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p	nucleosome positioning|ATP-dependent chromatin remodeling|regulation of cell cycle|nucleosome disassembly|regulation of DNA replication involved in S phase|regulation of transcription, DNA-dependent|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	sequence-specific DNA binding|DNA translocase activity|DNA binding	RSC complex|nucleus
YGR131W	FHN1	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PLASMA MEMBRANE	0.00186744892950477	0.913882287342423	1962	Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain	establishment of protein localization to plasma membrane	molecular_function	integral to membrane|membrane raft
YEL049W	PAU2	hom			0.0018521615884115	0.91458455637598	1963	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YDR382W	RPP2B	hom	FT	TRANSLATION|RIBOSOME	0.0018384302029097	0.915215404847935	1964	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	translational elongation|cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOL141W	PPM2	hom	FT	RNA PROCESSING|MITOCHONDRION	0.00181444034622569	0.916317676738155	1965	AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p	tRNA methylation|wybutosine biosynthetic process	tRNA methyltransferase activity	mitochondrion|cytoplasm
YJL088W	ARG3	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.00179452262950668	0.917232966620929	1966	Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine	arginine biosynthetic process|ornithine metabolic process	ornithine carbamoyltransferase activity	cytosol
YBL105C	PKC1	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.00177775927358173	0.918064322402076	1967	Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)	intracellular protein kinase cascade|regulation of nuclear-transcribed mRNA poly(A) tail shortening|fungal-type cell wall organization|signal transduction|actin filament organization|peroxisome degradation|protein phosphorylation|cytoplasmic mRNA processing body assembly	protein kinase C activity	site of polarized growth|cytoskeleton|nucleus|plasma membrane|cytoplasm
YJR098C_p	YJR098C	hom	FT	LIPID METABOLISM|MITOCHONDRION	0.00176476268041457	0.91860074604128	1968	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YFL034W_p	YFL034W	hom			0.00174949021966813	0.919338748512895	1969	Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk	biological_process	molecular_function	integral to membrane
YDL109C_p	YDL109C	hom	FT	LIPID METABOLISM	0.00171326181363745	0.920968313566262	1970	Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication	cellular lipid metabolic process	molecular_function	cellular_component
YDR378C	LSM6	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00165130565875626	0.923953463485986	1971	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasmic mRNA processing body
YGL146C_p	RRT6	hom			0.00162031882664739	0.925242792104624	1972	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins	biological_process	molecular_function	membrane
YBL004W	UTP20	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00156610633499046	0.927737046910651	1973	Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleoplasm|small-subunit processome|preribosome, small subunit precursor|nucleolus|90S preribosome|cytoplasm
YPL235W	RVB2	het	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0015210179564484	0.929895606511107	1974	ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly	regulation of transcription from RNA polymerase II promoter|rRNA processing|chromatin remodeling|box C/D snoRNP assembly|histone exchange	ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 3'-5' DNA helicase activity	nuclear telomeric heterochromatin|ASTRA complex|R2TP complex|Swr1 complex|nucleus|Ino80 complex
YOR298W	MUM3	hom	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	0.0015115301760097	0.930259124704334	1975	Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases	ascospore wall assembly|phospholipid biosynthetic process	transferase activity, transferring acyl groups	cellular_component
YDR048C_d	YDR048C	hom			0.00148436067405958	0.931499405935844	1976	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR125W_p	YLR125W	hom			0.00147793220249525	0.931795343522749	1977	Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene	biological_process	molecular_function	cellular_component
YOR243C	PUS7	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00143136864719032	0.933949024362972	1978	Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria	snRNA pseudouridine synthesis|tRNA pseudouridine synthesis|enzyme-directed rRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus
YJL175W_d	YJL175W	hom			0.00142165637541983	0.9344157133942	1979	Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor	Unknown	Unknown	Unknown
YNL067W	RPL9B	hom	FT	TRANSLATION|RIBOSOME	0.00139398584149806	0.935660702204949	1980	Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR107C	TMN2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	0.00139224559435198	0.935740849247973	1981	Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments	cellular copper ion homeostasis|pseudohyphal growth|vacuolar transport|invasive growth in response to glucose limitation	molecular_function	fungal-type vacuole membrane|integral to membrane
YBL081W_p	YBL081W	hom			0.00138890693838459	0.936037835004735	1982	Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport	biological_process	molecular_function	cellular_component
YGL148W	ARO2	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.00138029604728355	0.936319645224758	1983	Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress	aromatic amino acid family biosynthetic process	chorismate synthase activity|riboflavin reductase (NADPH) activity	cytoplasm
YKL180W	RPL17A	het	FT	TRANSLATION|RIBOSOME	0.00136629397886457	0.936936127098462	1984	Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit|cytoplasm
YGR216C	GPI1	het	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM	0.00134947342177086	0.937710923296099	1985	Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs	GPI anchor biosynthetic process	phosphatidylinositol N-acetylglucosaminyltransferase activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane
YPR187W	RPO26	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.00133917241030191	0.938185442353527	1986	RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit	tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YFL041W	FET5	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0013372142258086	0.938303209156274	1987	Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport	iron ion transport	ferroxidase activity	fungal-type vacuole membrane|integral to membrane
YCR021C	HSP30	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|PLASMA MEMBRANE	0.00133358986975692	0.938442612868809	1988	Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase	negative regulation of ATPase activity|response to stress	molecular_function	integral to membrane|plasma membrane
YDL208W	NHP2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00132713622804727	0.93873992033849	1989	Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing	cleavage involved in rRNA processing|rRNA pseudouridine synthesis|snRNA pseudouridine synthesis	snoRNA binding	box H/ACA snoRNP complex
YPL041C_p	YPL041C	hom			0.00131868460407258	0.939192723913556	1990	Protein of unknown function involved in maintenance of proper telomere length	biological_process	molecular_function	cellular_component
YDR165W	TRM82	hom	FT	RNA PROCESSING|NUCLEUS	0.0013165909310971	0.939225741231274	1991	Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p	tRNA methylation	tRNA (guanine-N7-)-methyltransferase activity	tRNA methyltransferase complex|nucleus
YDL056W	MBP1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS	0.00128388286752406	0.940732741832017	1992	Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes	positive regulation of transcription involved in G1/S phase of mitotic cell cycle	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	MBF transcription complex|nucleus
YLR338W_d	OPI9	hom	FF		0.00127196530755589	0.941281887884585	1993	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C	Unknown	Unknown	Unknown
YLR390W-A	CCW14	hom	FT	CELL WALL ORG/BIOGENESIS|MITOCHONDRION	0.00126680216098613	0.941554632841463	1994	Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall	fungal-type cell wall organization	structural constituent of cell wall	mitochondrion|fungal-type cell wall
YIL014W	MNT3	hom	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0012421148836162	0.942657479475905	1995	Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation	protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	cellular_component
YIL042C	PKP1	hom	FT	SIGNALING|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|MITOCHONDRION	0.00124209975454022	0.942692326205314	1996	Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p	peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization	protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity	mitochondrion
YGR097W	ASK10	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|RNA POL II, HOLOENZYME	0.00123787136778813	0.942853046610033	1997	Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication	cellular protein catabolic process|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glycerol transport	molecular_function	DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YGR114C_d	YGR114C	het	FF		0.00123015745129213	0.943327028650508	1998	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6	Unknown	Unknown	Unknown
YOL154W	ZPS1	hom			0.00121432136124534	0.943938437044414	1999	Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH	biological_process	molecular_function	fungal-type cell wall|fungal-type vacuole
YPL152W	RRD2	hom	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	0.00121339541969046	0.943981114675075	2000	Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress	mitotic spindle organization in nucleus|response to osmotic stress	peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity	protein phosphatase type 2A complex
YJR137C	MET5	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS	0.00120958995945435	0.944198092353753	2001	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine	fungal-type cell wall organization|sulfate assimilation	sulfite reductase (NADPH) activity	sulfite reductase complex (NADPH)|cytoplasm
YDR094W_d	YDR094W	hom			0.00120189975389576	0.944510975478906	2002	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2	Unknown	Unknown	Unknown
YDL097C	RPN6	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	0.00119442774650242	0.944880022162776	2003	Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress	proteasome assembly|ubiquitin-dependent protein catabolic process	structural molecule activity	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YJL004C	SYS1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00118723322932471	0.945219672132628	2004	Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation	vesicle organization|Golgi to plasma membrane protein transport|Golgi to endosome transport	molecular_function	trans-Golgi network|integral to membrane|integral to Golgi membrane
YCL023C_d	YCL023C	hom			0.00117600400373278	0.945704657745371	2005	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4	Unknown	Unknown	Unknown
YKL122C	SRP21	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEUS	0.00117518217955285	0.945742542300594	2006	Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER	signal sequence binding	nucleus|signal recognition particle, endoplasmic reticulum targeting
YMR074C	YMR074C	hom	FT	NUCLEUS	0.00116997810633748	0.945982443171104	2007	Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress	apoptotic process	molecular_function	nucleus|cytoplasm
YML101C-A_d	YML101C-A	hom			0.00116419294727372	0.946249137074122	2008	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL109W_d	YNL109W	hom			0.00115560425404176	0.946645084062802	2009	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C	Unknown	Unknown	Unknown
YGR088W	CTT1	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	0.00113840314959106	0.947438110974147	2010	Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide	response to reactive oxygen species	catalase activity	cytoplasm
YGR236C	SPG1	hom	FT	MITOCHONDRION	0.00113649204079272	0.947526222538478	2011	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YOR087W	YVC1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.00113259367586146	0.947705958423474	2012	Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock	cellular cation homeostasis	voltage-gated ion channel activity|calcium activated cation channel activity|sodium channel activity|calcium channel activity|potassium channel activity	fungal-type vacuole membrane|fungal-type vacuole
YGR022C_d	YGR022C	hom			0.00112295275003023	0.948150469090654	2013	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W	Unknown	Unknown	Unknown
YBR090C_p	YBR090C	hom	FT	NUCLEUS	0.00109781842908739	0.949362265126565	2014	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YNR009W	NRM1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS	0.00109187355903015	0.94958353519205	2015	Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase	negative regulation of transcription involved in G1 phase of mitotic cell cycle	repressing transcription factor binding|transcription factor binding transcription factor activity	MBF transcription complex|nucleus|cytoplasm
YLR014C	PPR1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM|NUCLEUS	0.00108376393975914	0.949957497943642	2016	Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding|zinc ion binding	nucleus
YIL114C	POR2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.00107848084197813	0.950201125889746	2017	Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication	DNA transport|ion transport|cell redox homeostasis	voltage-gated anion channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane
YNL263C	YIF1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.00107791313671582	0.950227305668658	2018	Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|endoplasmic reticulum membrane|ER to Golgi transport vesicle
YML047W-A_d	YML047W-A	hom			0.00105675627778436	0.951239340041804	2019	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML065W	ORC1	het	FT	GENE SILENCING|NUCLEUS|CHROMOSOME	0.00104011659451971	0.951970416008504	2020	Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity	pre-replicative complex assembly|DNA replication initiation|chromatin silencing at silent mating-type cassette	chromatin binding|DNA replication origin binding|ATPase activity|ATP binding	DNA replication preinitiation complex|nucleus|pre-replicative complex|nuclear origin of replication recognition complex
YFR025C	HIS2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.00103633719484954	0.952158983329595	2021	Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control	histidine biosynthetic process	histidinol-phosphatase activity	intracellular
YBL086C_p	YBL086C	hom			0.0010198502493644	0.952905159496767	2022	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YJL171C	YJL171C	hom	FT	MITOCHONDRION|PLASMA MEMBRANE	0.00100544169724284	0.953569763793606	2023	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrion|fungal-type cell wall|plasma membrane
YML108W	YML108W	hom	FT	NUCLEUS	0.00100186995788378	0.953734517718082	2024	Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YNL218W	MGS1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.000963903934980867	0.955485900431655	2025	Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress	regulation of DNA repair|DNA replication, Okazaki fragment processing|DNA strand renaturation	ubiquitin binding|single-stranded DNA-dependent ATPase activity|enzyme activator activity	nucleus|cytoplasm
YFR016C	YFR016C	hom			0.000962026631801304	0.955572506569523	2026	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene	biological_process	molecular_function	cellular bud|cytoplasm
YGR209C	TRX2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS|ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS	0.000961575806507807	0.95559330469344	2027	Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress	vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|sulfate assimilation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic	disulfide oxidoreductase activity	cytosol|fungal-type vacuole
YBR118W	TEF2	hom	FT	TRANSLATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|CYTOSKELETON|RIBOSOME	0.00095837445416681	0.955740994974292	2028	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication	translational elongation|tRNA export from nucleus	GDP binding|GTP binding|translation elongation factor activity	ribosome|eukaryotic translation elongation factor 1 complex|cytoplasm
YNL142W	MEP2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.000937940223748483	0.95670955333304	2029	Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation	nitrogen utilization|ammonium transport|pseudohyphal growth	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YPL143W	RPL33A	het	FT	TRANSLATION|RIBOSOME	0.000936930232350265	0.956794834700428	2030	Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YMR026C	PEX12	hom	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	0.000911991253688678	0.957931214488493	2031	C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder	protein import into peroxisome matrix	ubiquitin-protein ligase activity|protein binding	integral to peroxisomal membrane
YDR465C	RMT2	hom	FT	NUCLEUS	0.000889254995026612	0.959003576753619	2032	Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress	peptidyl-arginine methylation	protein-arginine N5-methyltransferase activity	nucleus|cytoplasm
YDL157C_p	YDL157C	hom	FT	MITOCHONDRION	0.000882712894416606	0.959231974958516	2033	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YFL009W	CDC4	het	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.000858505203780743	0.960354979291422	2034	F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p	meiosis|G2/M transition of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle	ubiquitin-protein ligase activity|ubiquitin binding	nuclear SCF ubiquitin ligase complex|SCF ubiquitin ligase complex|nucleus|nuclear matrix
YKR023W_p	YKR023W	hom	FT	NUCLEUS|MITOCHONDRION	0.000856026151333911	0.960463475531569	2035	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YJR049C	UTR1	hom	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM|NUCLEUS	0.000852104682735231	0.960644445714656	2036	ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication	cellular iron ion homeostasis|NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	nucleus|cytoplasm
YLR346C_p	YLR346C	hom	FT	MITOCHONDRION	0.000845680793215165	0.960946722842134	2037	Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene	biological_process	molecular_function	mitochondrion
YOR301W	RAX1	hom	FT	CELL CYCLE|SIGNALING|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.000836484610859762	0.96136530978005	2038	Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily	cellular bud site selection	molecular_function	integral to membrane|cellular bud neck
YMR270C	RRN9	het	FT	NUCLEUS	0.000828514113305661	0.961750266524654	2039	Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I	transcription of nuclear large rRNA transcript from RNA polymerase I promoter	TBP-class protein binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity	nucleolus|RNA polymerase I upstream activating factor complex
YBR102C	EXO84	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|SITE OF POLARIZED GROWTH	0.000827862674217792	0.961763224474224	2040	Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate	spliceosomal complex assembly|Golgi to plasma membrane transport|exocyst localization|exocytosis|exocyst assembly	molecular_function	incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip|exocyst
YML031W	NDC1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON|NUCLEAR PORE	0.00082042220747161	0.962106620301411	2041	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1	nucleocytoplasmic transport|nuclear pore organization|spindle pole body duplication associated with nuclear envelope	structural constituent of nuclear pore	integral to membrane|nuclear pore transmembrane ring|spindle pole body|nuclear pore
YJL100W	LSB6	hom	FT	LIPID METABOLISM|PLASMA MEMBRANE	0.000815524044150964	0.962332686416505	2042	Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization	phosphatidylinositol phosphorylation	1-phosphatidylinositol 4-kinase activity	fungal-type vacuole membrane|plasma membrane|cytoplasm
YIL108W	YIL108W	hom	FT	PROTEOLYSIS	0.000812740138407564	0.962461174041127	2043	Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress	biological_process	molecular_function	cytoplasm
YLR004C	THI73	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.000809671546889798	0.96262509581185	2044	Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs	transport	transporter activity	integral to membrane|endoplasmic reticulum
YDR143C	SAN1	hom	FT	PROTEOLYSIS|NUCLEUS	0.000805764849143543	0.962783113907261	2045	Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition	nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to misfolded protein|response to stress	ubiquitin-protein ligase activity	nucleus|cytoplasm
YBR165W	UBS1	hom	FT	PROTEIN LOCALIZATION|NUCLEUS	0.000800847039809014	0.963010095795672	2046	Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity	protein export from nucleus|protein ubiquitination	molecular_function	nucleus
YOR300W_d	YOR300W	hom			0.000797809644979184	0.963150288498306	2047	Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7	Unknown	Unknown	Unknown
YKL205W	LOS1	hom	FT	RNA PROCESSING|RNA LOCALIZATION|NUCLEUS|MITOCHONDRION	0.000791840572080787	0.963442149418215	2048	Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus	tRNA binding|Ran GTPase binding	mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YCL074W	YCL074W	hom	FT	NUCLEUS	0.000766020187203569	0.964617616686035	2049	Pseudogene: encodes fragment of Ty Pol protein	transposition, RNA-mediated	ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity	retrotransposon nucleocapsid
YCR084C	TUP1	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.000763341698563723	0.9647412550958	2050	General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes	nucleosome positioning|regulation of transcription from RNA polymerase II promoter in response to osmotic stress|histone exchange|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown	ubiquitin binding|histone deacetylase binding|histone binding|phosphatidylinositol-3,5-bisphosphate binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|mediator complex binding	nucleus|transcriptional repressor complex
YMR093W	UTP15	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|CHROMOSOME	0.000762537957684073	0.964836131951302	2051	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|rDNA heterochromatin|nucleolus|t-UTP complex|90S preribosome
YGR032W	GSC2	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PLASMA MEMBRANE|CYTOSKELETON	0.000760379709680834	0.964877980797058	2052	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)	ascospore wall assembly|(1->3)-beta-D-glucan biosynthetic process	1,3-beta-D-glucan synthase activity	1,3-beta-D-glucan synthase complex|integral to membrane|actin cap|prospore membrane
YNL080C	EOS1	hom	FT	CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.000759367385746992	0.964924710007348	2053	Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene	cellular response to oxidative stress|protein N-linked glycosylation	molecular_function	integral to membrane|endoplasmic reticulum membrane
YHR151C	MTC6	hom			0.000737203134382056	0.96594784913866	2054	Protein of unknown function; mtc6 is synthetically sick with cdc13-1	biological_process	molecular_function	cellular_component
YDR007W	TRP1	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.000737125189728497	0.965951447294868	2055	Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)	tryptophan biosynthetic process	phosphoribosylanthranilate isomerase activity	cytoplasm
YBR029C	CDS1	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.000722207058160959	0.966640125132953	2056	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids	phosphatidylserine metabolic process|phosphatidylglycerol biosynthetic process	phosphatidate cytidylyltransferase activity	mitochondrion|integral to membrane|endoplasmic reticulum
YLR290C_p	YLR290C	hom	FT	MITOCHONDRION	0.000717815168672824	0.966842876260522	2057	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene	biological_process	molecular_function	mitochondrion
YGL067W	NPY1	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.000715695951017885	0.966940710493275	2058	NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member	NADH metabolic process	NAD+ diphosphatase activity	peroxisome|cytoplasm
YLR328W	NMA1	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.000715025772233508	0.966971649574284	2059	Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication	NAD biosynthetic process	nicotinamide-nucleotide adenylyltransferase activity	nucleus|cytoplasm
YOR347C	PYK2	hom	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.000712671864433678	0.967080319095804	2060	Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication	pyruvate metabolic process	pyruvate kinase activity	cytosol|mitochondrion
YDL110C	TMA17	hom	FT	NUCLEUS	0.000712225286040527	0.967135270489726	2061	Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YGL235W_p	YGL235W	hom			0.000707575684678948	0.967315589286655	2062	Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	biological_process	molecular_function	cellular_component
YPR011C_p	YPR011C	hom	FT	MITOCHONDRION	0.000703016395001718	0.967530915308247	2063	Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	transport	transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YNL190W_p	YNL190W	hom			0.000700673396741848	0.967634244782608	2064	Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site	cellular response to water deprivation	molecular_function	fungal-type cell wall
YOL123W	HRP1	het	FT	RNA PROCESSING|NUCLEUS	0.000699172031790313	0.967703558455275	2065	Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences	mRNA cleavage|mRNA polyadenylation	mRNA binding|RNA binding	mRNA cleavage factor complex|nucleus|cytoplasmic stress granule|cytoplasm
YDR244W	PEX5	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION	0.000699142572709378	0.967704918498186	2066	Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions	protein import into peroxisome matrix, docking	peroxisome matrix targeting signal-1 binding|protein binding, bridging	cytosol|peroxisomal membrane|peroxisome
YML077W	BET5	het	FT	VESICLE-MEDIATED TRANSPORT|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.000697788596173475	0.967767427887939	2067	Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi	ER to Golgi vesicle-mediated transport	Rab guanyl-nucleotide exchange factor activity	TRAPP complex
YNL305C	BXI1	hom	FT	SIGNALING|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.000687278256436974	0.96825266820177	2068	Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p	endoplasmic reticulum unfolded protein response|apoptotic process|calcium-mediated signaling	molecular_function	mitochondrion|integral to membrane|endoplasmic reticulum|fungal-type vacuole
YDL184C	RPL41A	hom	FT	TRANSLATION|RIBOSOME	0.000675670691410861	0.968788578749074	2069	Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR177C	ATF2	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.000674460955466321	0.968872301663746	2070	Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking	steroid metabolic process|response to toxin|Unknown|sterol acetylation	alcohol O-acetyltransferase activity	integral to endoplasmic reticulum membrane|endoplasmic reticulum|cytoplasm
YML022W	APT1	hom	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.00067251139918972	0.968934442799829	2071	Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication	AMP biosynthetic process|adenine salvage	adenine phosphoribosyltransferase activity	nucleus|cytoplasm
YOR094W	ARF3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH	0.000668156650772453	0.969135502586718	2072	Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity	intracellular protein transport|positive regulation of phosphatidylinositol biosynthetic process|endocytosis|actin filament bundle assembly|actin cortical patch localization|cellular bud site selection	mRNA binding|GTPase activity	cellular bud neck|cellular bud tip
YBR147W	RTC2	hom	FT	MITOCHONDRION	0.000665941483117839	0.969237778165959	2073	Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter	biological_process	molecular_function	mitochondrion|integral to membrane
YML003W_p	YML003W	hom			0.000660625699501065	0.969483213047669	2074	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR006C	PLB2	hom	FT	LIPID METABOLISM	0.000659206076629154	0.969548758901349	2075	Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine	glycerophospholipid metabolic process	lysophospholipase activity	extracellular region|fungal-type cell wall
YHL006C	SHU1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.000658204800868793	0.969594989242769	2076	Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function	recombinational repair|maintenance of rDNA	molecular_function	nucleolus|Shu complex
YDR293C	SSD1	hom	FF|FT	CELL CYCLE|TRANSLATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|RNA LOCALIZATION|NUCLEUS|SITE OF POLARIZED GROWTH	0.000648774835358989	0.970133291317116	2077	Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function	regulation of fungal-type cell wall organization|negative regulation of translation|intracellular mRNA localization	mRNA binding|mRNA 5'-UTR binding|translation repressor activity, nucleic acid binding	nucleus|cellular bud|cytoplasmic stress granule|cytoplasmic mRNA processing body|cellular bud neck|cytoplasm
YJL001W	PRE3	het	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0006427943980799	0.970306522483457	2078	Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	endopeptidase activity	nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YPL234C	VMA11	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.000639689316696856	0.970449894009923	2079	Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane|fungal-type vacuole
YJR153W	PGU1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.000638268849982524	0.970515481814232	2080	Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins	pseudohyphal growth|pectin catabolic process	polygalacturonase activity	extracellular region
YMR233W	TRI1	hom	FT	NUCLEUS	0.000628758312391422	0.97095462096149	2081	Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication	biological_process	molecular_function	nucleolus|nucleus|cytoplasm
YAR007C	RFA1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.000616316171529239	0.971558854652792	2082	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination	establishment of protein localization|telomere maintenance via telomerase|telomere maintenance via recombination|nucleotide-excision repair|DNA repair|mitotic recombination|heteroduplex formation|DNA unwinding involved in replication|reciprocal meiotic recombination|DNA replication|double-strand break repair via homologous recombination|protein ubiquitination	double-stranded DNA binding|single-stranded DNA binding|sequence-specific DNA binding	condensed nuclear chromosome|chromosome, telomeric region|DNA replication factor A complex|cytoplasm
YJR078W	BNA2	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.000613099398665242	0.971677674075005	2083	Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp	de novo NAD biosynthetic process from tryptophan	tryptophan 2,3-dioxygenase activity|indoleamine 2,3-dioxygenase activity	cytoplasm
YKL010C	UFD4	hom	FT	PROTEOLYSIS|MITOCHONDRION	0.000605273659727775	0.97205988157149	2084	Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress	protein monoubiquitination|protein polyubiquitination	ubiquitin-protein ligase activity	mitochondrion|cytoplasm
YDL039C	PRM7	hom			0.000587801714426791	0.972845848027544	2085	Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements	conjugation with cellular fusion	molecular_function	integral to membrane
YCL058C	FYV5	hom	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS	0.000585393553476069	0.972961083820375	2086	Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis	pheromone-dependent signal transduction involved in conjugation with cellular fusion|cellular ion homeostasis	molecular_function	integral to membrane
YGR067C_p	YGR067C	hom	FT	NUCLEUS	0.000578504359921251	0.973303084208289	2087	Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p	biological_process	sequence-specific DNA binding	cellular_component
YBL051C	PIN4	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	0.000571530216206498	0.97359724972208	2088	Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage	G2/M transition of mitotic cell cycle|DNA damage checkpoint	molecular_function	cytoplasm
YFR014C	CMK1	hom	FT	SIGNALING|PROTEIN PHOSPHORYLATION	0.000569643116623073	0.973704013865035	2089	Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication	signal transduction|protein phosphorylation	protein kinase activity|calmodulin-dependent protein kinase activity	cytoplasm
YDL218W_p	YDL218W	hom			0.000554587376302119	0.974379678194822	2090	Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin	biological_process	molecular_function	integral to membrane|cytoplasm
YDR330W	UBX5	hom	FT	PROTEOLYSIS|NUCLEUS	0.000552113857094378	0.974509119561005	2091	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p	proteasomal ubiquitin-dependent protein catabolic process	molecular_function	nucleus|cytoplasm
YOR274W	MOD5	hom	FT	RNA PROCESSING|NUCLEUS|MITOCHONDRION	0.000548730142401993	0.974650173836096	2092	Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis	tRNA modification	tRNA dimethylallyltransferase activity	cytosol|mitochondrion|nucleolus|nucleus
YOR267C	HRK1	hom	FT	ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS	0.000547404694566289	0.974711385364143	2093	Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress	protein phosphorylation|cellular ion homeostasis	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YLR405W	DUS4	hom	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	0.000545877354102513	0.974796960173334	2094	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p	tRNA modification	tRNA dihydrouridine synthase activity	cellular_component
YGR008C	STF2	hom	FT	MITOCHONDRION	0.0005416475716202	0.974988452572276	2095	Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress	cellular response to desiccation	molecular_function	cytoplasm
YPL035C_d	YPL035C	hom			0.000539371565681263	0.975100949382633	2096	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene	Unknown	Unknown	Unknown
YDR169C	STB3	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.000525506430118455	0.975722707269724	2097	Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter by glucose	sequence-specific DNA binding	nucleus|cytoplasm
YJL085W	EXO70	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH	0.000521847345286111	0.975909671420324	2098	Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress	Golgi to plasma membrane transport|exocytosis|exocyst localization|exocyst assembly|vesicle fusion|vesicle docking involved in exocytosis	Rho GTPase binding|phosphatidylinositol-4,5-bisphosphate binding	incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip|exocyst
YKR060W	UTP30	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS	0.000503138127394596	0.976755777096174	2099	Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit	ribosomal small subunit biogenesis	molecular_function	nucleolus|nucleus|90S preribosome
YCL022C_d	YCL022C	hom			0.000464057963529682	0.978560769074321	2100	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W	Unknown	Unknown	Unknown
YFL012W_p	YFL012W	hom			0.000463293005312795	0.978596101255046	2101	Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin	biological_process	molecular_function	cellular_component
YPR060C	ARO7	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.000450376976899637	0.979192677964129	2102	Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis	aromatic amino acid family biosynthetic process	chorismate mutase activity	nucleus|cytoplasm
YDR110W	FOB1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.000444813020121206	0.979449674424081	2103	Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases	extrachromosomal circular DNA accumulation involved in cell aging|negative regulation of DNA replication|rDNA condensation|chromatin silencing at rDNA|replicative cell aging|protein localization to nucleolar rDNA repeats|DNA recombination	rDNA spacer replication fork barrier binding	nucleolus|rDNA heterochromatin
YGR292W	MAL12	hom	FT	CARBOHYDRATE METABOLISM	0.000434257892760486	0.979952175493501	2104	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose	sucrose catabolic process|maltose catabolic process	sucrose alpha-glucosidase activity|maltose alpha-glucosidase activity	plasma membrane
YBR294W	SUL1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.000430549956733368	0.980120352283753	2105	High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates	sulfate transport|transmembrane transport	sulfate transmembrane transporter activity	integral to membrane|plasma membrane
YPR026W	ATH1	hom	FT	CARBOHYDRATE METABOLISM	0.00042700450693923	0.980272255195729	2106	Acid trehalase required for utilization of extracellular trehalose	trehalose catabolic process|response to stress	alpha,alpha-trehalase activity	fungal-type cell wall|cell wall-bounded periplasmic space|fungal-type vacuole
YLR106C	MDN1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM|NUCLEUS|MITOCHONDRION	0.000421565337538603	0.980523496345101	2107	Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus	ribosomal large subunit assembly|rRNA processing	ATPase activity	nucleoplasm|mitochondrion|nucleus
YOL034W	SMC5	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.000409560451892491	0.981083664107046	2108	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair	DNA repair|resolution of recombination intermediates|recombinational repair|rDNA separation	damaged DNA binding|single-stranded DNA binding|ATPase activity	Smc5-Smc6 complex|nucleus
YGL125W	MET13	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.000403970978454134	0.981336212023062	2109	Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway	methionine biosynthetic process	methylenetetrahydrofolate reductase (NADPH) activity	mitochondrion
YGR074W	SMD1	het	FT	RNA PROCESSING|NUCLEUS	0.000401987982523889	0.98142781146759	2110	Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1; protein abundance increases in response to DNA replication stress	mRNA splicing, via spliceosome	mRNA binding	commitment complex|U1 snRNP|U4/U6 x U5 tri-snRNP complex|U2-type prespliceosome|U5 snRNP
YDR104C	SPO71	hom	FT	CELL WALL ORG/BIOGENESIS	0.00039042756242074	0.981961820453417	2111	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains	ascospore wall assembly	molecular_function	ascospore wall
YGR167W	CLC1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE	0.00038946641134149	0.982014268092162	2112	Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W	endocytosis|vesicle-mediated transport	structural molecule activity	clathrin vesicle coat
YJR108W	ABM1	hom	FT	CYTOSKELETON ORGANIZATION	0.000387012504772271	0.982119573324869	2113	Protein of unknown function, required for normal microtubule organization	microtubule cytoskeleton organization	molecular_function	cellular_component
YGR278W	CWC22	het	FT	RNA PROCESSING|NUCLEUS	0.000376690907884943	0.982596366438254	2114	Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex|U2-type catalytic step 1 spliceosome
YJR052W	RAD7	hom	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.000362546214443645	0.983262262667871	2115	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	damaged DNA binding|ubiquitin-protein ligase activity|DNA-dependent ATPase activity	nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YBL099W	ATP1	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION	0.000361104151135006	0.983318875989678	2116	Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrial nucleoid|proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, catalytic core
YER038W-A_d	YER038W-A	hom			0.000358333037687531	0.983459215221396	2117	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria	Unknown	Unknown	Unknown
YGR010W	NMA2	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.000351658375584193	0.983762429367474	2118	Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication	NAD biosynthetic process	nicotinamide-nucleotide adenylyltransferase activity	nucleus
YNL157W	IGO1	hom	FT	NUCLEUS	0.000351107307345647	0.983780613419743	2119	Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p	mRNA stabilization	molecular_function	nucleus|cytoplasmic mRNA processing body|cytoplasm
YER071C_p	TDA2	hom	FT	SITE OF POLARIZED GROWTH	0.000333769170720194	0.984599850813601	2120	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	mating projection tip|cytoplasm
YOR126C	IAH1	hom	FT	KETONE METABOLISM|LIPID METABOLISM	0.000323910963418941	0.985045722133477	2121	Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing	acetate metabolic process	hydrolase activity, acting on ester bonds	cellular_component
YPL169C	MEX67	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.000320588694621091	0.985196876852803	2122	Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP	mRNA export from nucleus|ribosomal large subunit export from nucleus	protein binding|RNA binding|structural constituent of nuclear pore	integral to membrane|nuclear RNA export factor complex|nuclear pore|cytoplasm
YFR004W	RPN11	het	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION|NUCLEUS|MITOCHONDRION	0.00031759696955019	0.985354716802585	2123	Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress	protein deubiquitination|proteasomal ubiquitin-dependent protein catabolic process|peroxisome fission|mitochondrial fission	metallopeptidase activity|ubiquitin-specific protease activity	cytosol|mitochondrion|proteasome storage granule|nucleus|proteasome regulatory particle, lid subcomplex
YKL174C	TPO5	hom	FT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00030800832845746	0.985769221404822	2124	Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles	polyamine transport	polyamine transmembrane transporter activity	integral to membrane|Golgi apparatus
YOL022C	TSR4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	0.000303199848925609	0.985991362551979	2125	Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2	maturation of SSU-rRNA	molecular_function	cytoplasm
YDL176W	YDL176W	hom			0.000302276296500485	0.986044443071375	2126	Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene	biological_process	molecular_function	cellular_component
YER171W	RAD3	het	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME	0.000301797197320618	0.986056162167255	2127	5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress	regulation of transposition, RNA-mediated|phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair, DNA incision|regulation of mitotic recombination|transcription from RNA polymerase II promoter	damaged DNA binding|ATP-dependent 5'-3' DNA helicase activity|core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YJR094W-A	RPL43B	hom	FT	TRANSLATION|RIBOSOME	0.000299926772247603	0.98614257209632	2128	Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDL197C	ASF2	hom	FT	GENE SILENCING|NUCLEUS|CHROMOSOME	0.000293929740485928	0.986419624161432	2129	Anti-silencing protein that causes derepression of silent loci when overexpressed	chromatin silencing at silent mating-type cassette	molecular_function	nuclear chromosome, telomeric region|nucleus
YOL075C_p	YOL075C	hom	FT	NUCLEOTIDE METABOLISM	0.000292704969108494	0.986476206595314	2130	Putative ABC transporter	transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YKL152C	GPM1	het	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.000287181644725607	0.986731375986099	2131	Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis	gluconeogenesis|glycolysis	phosphoglycerate mutase activity	cytosol|mitochondrion
YLR223C	IFH1	het	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|GENE SILENCING|NUCLEUS|CHROMOSOME	0.00028446462527293	0.986856898752674	2132	Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing	positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|chromatin silencing at telomere	transcription coactivator activity	nuclear chromatin|nucleolus|nucleus|CURI complex
YER151C	UBP3	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS	0.000283103615353724	0.986919775764064	2133	Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|regulation of response to osmotic stress	ubiquitin-specific protease activity|mRNA binding	cytoplasm
YJL052W	TDH1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.000278499698953265	0.9871363090145	2134	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress	gluconeogenesis|glycolysis	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YOR346W	REV1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.000272606951893268	0.987404711613567	2135	Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress	error-prone translesion synthesis|error-free translesion synthesis	deoxycytidyl transferase activity|DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|replication fork
YJR037W_d	YJR037W	hom			0.00027030622344671	0.987525908053165	2136	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces	Unknown	Unknown	Unknown
YOR079C	ATX2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.000270200234237592	0.987521485192929	2137	Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation	cellular manganese ion homeostasis	manganese ion transmembrane transporter activity	integral to membrane|Golgi membrane
YDL230W	PTP1	hom	FT	MITOCHONDRION	0.000266068005356922	0.987706807075217	2138	Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation	pseudohyphal growth|invasive growth in response to glucose limitation|protein dephosphorylation	protein tyrosine phosphatase activity	mitochondrion|cytoplasm
YDR171W	HSP42	hom	FT	CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.000261185748734631	0.987950370253443	2139	Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	cytoskeleton organization	unfolded protein binding	cytoskeleton|chaperonin-containing T-complex|cytoplasm
YGL139W	FLC3	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.000253963661694929	0.988274775399386	2140	Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER	FAD transport|transmembrane transport	FAD transmembrane transporter activity	mitochondrion|integral to membrane|endoplasmic reticulum
YNL042W	BOP3	hom	FT	NUCLEUS	0.000250326364843784	0.988440968098904	2141	Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury	cellular response to methylmercury	molecular_function	nucleus|cytoplasm
YDR215C_d	YDR215C	hom			0.000249904794499751	0.988460433108721	2142	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein	Unknown	Unknown	Unknown
YOR234C	RPL33B	hom	FT	TRANSLATION|RIBOSOME	0.000246854613872554	0.988594464427198	2143	Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR173W	RBG2	hom	FT	TRANSLATION	0.000244657926760427	0.988695952138817	2144	Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein	cytoplasmic translation	GTP binding	cytoplasm
YLL046C	RNP1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	0.000240332246821995	0.988904081216259	2145	Ribonucleoprotein that contains two RNA recognition motifs (RRM)	ribosome biogenesis	RNA binding	cytoplasm
YDR133C_d	YDR133C	hom			0.000238361660278741	0.989003274466372	2146	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C	Unknown	Unknown	Unknown
YDR324C	UTP4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.000230209468595057	0.989363480431179	2147	Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript	positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus|t-UTP complex|90S preribosome
YLR269C_d	YLR269C	hom			0.000229736108427189	0.989385350111454	2148	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YFL021W	GAT1	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.000228389370900358	0.989447570682047	2149	Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p	nitrogen catabolite activation of transcription from RNA polymerase II promoter|nitrogen catabolite activation of transcription	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity	cytosol|nucleus
YNL078W	NIS1	hom	FT	CELL CYCLE|NUCLEUS|SITE OF POLARIZED GROWTH	0.000227233722748592	0.989500962790657	2150	Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network	regulation of mitosis	molecular_function	nucleus|cellular bud neck
YLR267W_p	BOP2	hom			0.000225659362083353	0.989573699914707	2151	Protein of unknown function	biological_process	molecular_function	cellular_component
YNL047C	SLM2	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE	0.000220921072289858	0.989826149503085	2152	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol binding	plasma membrane
YDL036C	PUS9	hom	FT	RNA PROCESSING|NUCLEUS|MITOCHONDRION	0.000210667251142167	0.990266355514169	2153	Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|nucleus|cytoplasm
YER063W	THO1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION|NUCLEUS	0.000209935589595593	0.990307392922501	2154	Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation	poly(A)+ mRNA export from nucleus|transcription, DNA-dependent|ribonucleoprotein complex assembly	chromatin binding|double-stranded DNA binding|RNA binding	nucleus
YDR521W_d	YDR521W	hom			0.000203594477445758	0.990597338088757	2155	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol	Unknown	Unknown	Unknown
YHR180W_d	YHR180W	hom			0.000200611673199687	0.990730940819994	2156	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL066W_d	YKL066W	hom			0.000189145276355557	0.991260712253626	2157	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene YNK1	Unknown	Unknown	Unknown
YNL188W	KAR1	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	0.000186604349332694	0.991387111802726	2158	Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p	karyogamy involved in conjugation with cellular fusion|spindle pole body duplication associated with nuclear envelope	protein binding	half bridge of spindle pole body
YDR028C	REG1	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.000179540341970984	0.991704483215778	2159	Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p	cellular response to glucose starvation|vacuolar protein catabolic process|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of carbohydrate metabolic process	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex|cytoplasm
YGR001C_p	YGR001C	hom			0.00017714437131679	0.991821286960304	2160	Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae	biological_process	methyltransferase activity	cytoplasm
YJR146W_p	YJR146W	hom			0.000170021930694208	0.992144259134264	2161	Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2	biological_process	molecular_function	cellular_component
YOL117W	RRI2	hom	FT	SIGNALING|NUCLEUS	0.000164743045535574	0.992389293666736	2162	Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	molecular_function	signalosome
YML109W	ZDS2	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|GENE SILENCING|NUCLEUS|SITE OF POLARIZED GROWTH	0.000158612523937727	0.992671407205664	2163	Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication	positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|establishment of cell polarity|regulation of protein localization|chromatin silencing at rDNA|cell aging	molecular_function	nucleus|cellular bud neck|cellular bud tip|cytoplasm
YMR034C_p	YMR034C	hom			0.000155085484081263	0.992834367454391	2164	Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene	biological_process	sterol transporter activity	integral to membrane
YPL152W-A_p	YPL152W-A	hom			0.00014144705792679	0.993464508056588	2165	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YDL237W	AIM6	hom			0.000130879446711142	0.993952769627898	2166	Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene	biological_process	molecular_function	cellular_component
YKL130C	SHE2	hom	FT	RNA LOCALIZATION|NUCLEUS|SITE OF POLARIZED GROWTH	0.000130797940369798	0.993956535522473	2167	RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud	mating type switching|intracellular mRNA localization	mRNA binding	cellular bud tip|cytoplasm
YDR327W_d	YDR327W	het			0.000128889631958346	0.994044706470825	2168	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1	Unknown	Unknown	Unknown
YOR286W	RDL2	hom	FT	MITOCHONDRION	0.000126243517953322	0.994166966902615	2169	Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	thiosulfate sulfurtransferase activity	mitochondrion
YOR364W_d	YOR364W	hom			0.000121559023072341	0.994383408540929	2170	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C	Unknown	Unknown	Unknown
YJR031C	GEA1	hom	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|GOLGI APPARATUS	0.00012149721701034	0.994386264220945	2171	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization	ARF guanyl-nucleotide exchange factor activity	integral to membrane|Golgi cis cisterna|Golgi-associated vesicle|extrinsic to membrane
YDR459C	PFA5	hom	FT	PLASMA MEMBRANE	0.000116657035856003	0.994609899601765	2172	Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain	protein palmitoylation	palmitoyltransferase activity	integral to membrane|plasma membrane
YER002W	NOP16	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.000107663036602954	0.995026200544583	2173	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis	ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YIL021W	RPB3	het	FF|FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.000104712866420777	0.995164655225833	2174	RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit	termination of RNA polymerase II transcription|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	nucleoplasm|DNA-directed RNA polymerase II, core complex
YML023C	NSE5	het	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.000102831606381049	0.995249399473949	2175	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair	DNA repair	molecular_function	Smc5-Smc6 complex|nucleus
YAL003W	EFB1	het	FT	TRANSLATION|RIBOSOME	0.000102335146361908	0.995272334597257	2176	Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site	translational elongation	translation elongation factor activity|guanyl-nucleotide exchange factor activity	ribosome|eukaryotic translation elongation factor 1 complex
YKL057C	NUP120	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.000100812954856495	0.995341961244523	2177	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160	double-strand break repair|protein export from nucleus|ribosomal large subunit export from nucleus|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore outer ring
YER089C	PTC2	hom	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS	0.000100134434041233	0.995373311786022	2178	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication	endoplasmic reticulum unfolded protein response|inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation|DNA damage checkpoint	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YJR106W	ECM27	hom	FT	CELL WALL ORG/BIOGENESIS	9.98202784289864e-05	0.995387827111095	2179	Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p	fungal-type cell wall organization	molecular_function	integral to membrane
YGR025W_d	YGR025W	hom			9.30362284997537e-05	0.995703202630673	2180	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL179C	COY1	hom	FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	9.07795434278755e-05	0.995805548143964	2181	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function	Golgi vesicle transport	molecular_function	Golgi membrane
YJR100C	AIM25	hom	FT	MITOCHONDRION	8.91074691255034e-05	0.995885261505164	2182	Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YOR199W_d	YOR199W	hom			8.30804297501046e-05	0.996164144154314	2183	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL187C	FAT3	hom	FT	MITOCHONDRION	8.1592254182331e-05	0.996234541189034	2184	Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|integral to membrane
YKR032W_d	YKR032W	hom			8.0668320928441e-05	0.996276623782522	2185	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR138C	TPO2	hom	FT	PLASMA MEMBRANE	8.02007023959076e-05	0.996296548444431	2186	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication	spermine transport	spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YGL254W	FZF1	hom	FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS|NUCLEUS	7.64253372235567e-05	0.996468776826952	2187	Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress	positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YKL024C	URA6	het	FT	NUCLEOTIDE METABOLISM|NUCLEUS	7.58572414116165e-05	0.99649502545368	2188	Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)	'de novo' pyrimidine nucleobase biosynthetic process|nucleobase-containing compound metabolic process	uridylate kinase activity|adenylate kinase activity	nucleus|cytoplasm
YDL046W	NPC2	hom			7.39519007484183e-05	0.996585609168478	2189	Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes	intracellular sterol transport	molecular_function	fungal-type vacuole lumen|fungal-type vacuole
YLR323C	CWC24	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	7.21348131522755e-05	0.996667018769608	2190	Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p	generation of catalytic spliceosome for first transesterification step|snoRNA splicing	molecular_function	nucleus|U2-type spliceosomal complex
YGR174W-A_p	YGR174W-A	hom			7.04975281410299e-05	0.996746070308143	2191	Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YLR016C	PML1	hom	FT	RNA PROCESSING|RNA LOCALIZATION|NUCLEUS	6.86713135558038e-05	0.996827521642287	2192	Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p	mRNA export from nucleus|mRNA splicing, via spliceosome|maintenance of RNA location	molecular_function	RES complex|nucleus|cytoplasm
YDL222C	FMP45	hom	FT	CELL WALL ORG/BIOGENESIS|MITOCHONDRION|PLASMA MEMBRANE	6.70825513229836e-05	0.996903230803154	2193	Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C	fungal-type cell wall organization|ascospore formation	molecular_function	cell cortex|mitochondrion|integral to membrane|plasma membrane
YGR077C	PEX8	hom	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	4.93646645226846e-05	0.997719107496007	2194	Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p	protein targeting to peroxisome|peroxisome organization	peroxisome targeting sequence binding	peroxisomal matrix|peroxisomal membrane|extrinsic to intraperoxisomal membrane
YMR204C	INP1	hom	FT	PEROXISOME ORGANIZATION	4.83552474975501e-05	0.99776608059576	2195	Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane	peroxisome inheritance	molecular_function	peroxisome|extrinsic to intraperoxisomal membrane
YLR288C	MEC3	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME	4.33047895419076e-05	0.997999103168305	2196	DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1	telomere maintenance via recombination|DNA damage checkpoint|DNA metabolic process|chromatin silencing at telomere	DNA binding	nucleus|checkpoint clamp complex
YGR199W	PMT6	hom	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	3.9974285284994e-05	0.998154090625861	2197	Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases	protein O-linked glycosylation|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane
YFL027C	GYP8	hom	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	3.97548325169678e-05	0.998163128550617	2198	GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport	vesicle-mediated transport	Rab GTPase activator activity	intracellular
YGR047C	TFC4	het	FT	NUCLEUS	3.91602760568042e-05	0.998190599975651	2199	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102	transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter	RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending	transcription factor TFIIIC complex
YIL059C_d	YIL059C	hom			3.83566971543228e-05	0.998227729266272	2200	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W	Unknown	Unknown	Unknown
YPL233W	NSL1	het	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	3.6516509305753e-05	0.998312754993955	2201	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation	chromosome segregation	molecular_function	nuclear MIS12/MIND type complex|kinetochore|spindle pole
YGR003W	CUL3	hom	FT	PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	2.88993465269493e-05	0.998664904668846	2202	Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3	protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	nucleus|Cul3-RING ubiquitin ligase complex|cytoplasm
YLR129W	DIP2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	2.86093804992512e-05	0.998678103433811	2203	Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YPR056W	TFB4	het	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME	2.82536339608035e-05	0.99869454068961	2204	Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YLR042C_p	YLR042C	hom			2.64228405031568e-05	0.998779132442975	2205	Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene	biological_process	molecular_function	fungal-type cell wall
YKL097C_d	YKL097C	hom			2.43536345004651e-05	0.998874907843202	2206	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species	Unknown	Unknown	Unknown
YOR050C_d	YOR050C	hom			2.18414685421031e-05	0.998990814646455	2207	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable	Unknown	Unknown	Unknown
YGL209W	MIG2	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|MITOCHONDRION	1.30356758873347e-05	0.999397686313497	2208	Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	mitochondrion|nucleus
YKL201C	MNN4	hom	FT	CARBOHYDRATE METABOLISM	1.20196802239008e-05	0.999444630407216	2209	Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication	protein O-linked glycosylation|protein N-linked glycosylation|response to stress	molecular_function	membrane
YDR384C	ATO3	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION|PLASMA MEMBRANE	1.18410281571501e-05	0.999453374690023	2210	Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters	ammonium transport|nitrogen utilization|transmembrane transport	ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YLL017W	YLL017W	hom	FT	SIGNALING	9.56252627841162e-06	0.999558163246972	2211	Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication	Ras protein signal transduction	Ras guanyl-nucleotide exchange factor activity	membrane
YOR296W_p	YOR296W	hom			-4.54740514220388e-06	0.999790012376509	2212	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene	biological_process	molecular_function	cytoplasm
YLR360W	VPS38	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|GOLGI APPARATUS	-4.69233313366637e-06	0.999783190628088	2213	Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated	ER-associated protein catabolic process|late endosome to vacuole transport	molecular_function	phosphatidylinositol 3-kinase complex II
YPL012W	RRP12	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|RIBOSOME	-5.03766032423668e-06	0.999767234776892	2214	Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosome biogenesis	molecular_function	ribosome|nucleus|90S preribosome
YLR400W_d	YLR400W	hom			-5.38593697575843e-06	0.999751142645876	2215	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL151C	YKL151C	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	-5.97037203261603e-06	0.999724262228943	2216	NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	nicotinamide nucleotide metabolic process	ATP-dependent NAD(P)H-hydrate dehydratase activity	cytoplasm
YGL243W	TAD1	hom	FT	RNA PROCESSING|NUCLEUS	-1.65570111045904e-05	0.999234982988108	2217	tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala	tRNA modification	tRNA-specific adenosine-37 deaminase activity	nucleus
YOR266W	PNT1	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	-1.73085879117111e-05	0.999200256378862	2218	Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine	protein insertion into mitochondrial membrane from inner side	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YBR210W	ERV15	hom	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION	-1.83849908231127e-05	0.99915064784583	2219	Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|axial cellular bud site selection	molecular_function	integral to membrane|ER to Golgi transport vesicle
YHL015W	RPS20	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	-1.99740758936119e-05	0.999077097509129	2220	Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YLR144C	ACF2	hom	FT	CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	-2.10943418341155e-05	0.999025335628777	2221	Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress	actin cytoskeleton organization	glucan endo-1,3-beta-D-glucosidase activity	intracellular
YMR140W	SIP5	hom	FT	RESPONSE TO NUTRIENT LEVELS	-2.11832049643386e-05	0.999021229708607	2222	Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress	cellular response to glucose starvation	molecular_function	cytoplasm
YHL012W_p	YHL012W	hom			-2.42324820489423e-05	0.998880337903487	2223	Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YOR326W	MYO2	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	-2.48640775329776e-05	0.998851326350269	2224	Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication	vacuole inheritance|establishment of mitotic spindle orientation|peroxisome inheritance|budding cell apical bud growth|unidimensional cell growth|mitochondrion inheritance|membrane addition at site of cytokinesis|vesicle transport along actin filament|vesicle-mediated transport|Golgi inheritance	microfilament motor activity|actin filament binding|calmodulin binding	fungal-type vacuole membrane|incipient cellular bud site|filamentous actin|myosin V complex|actin filament bundle|cellular bud neck|cellular bud tip|vesicle|mating projection tip
YMR005W	TAF4	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	-2.76891558197563e-05	0.998720622382608	2225	TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate	RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter	chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|RNA polymerase II activating transcription factor bind