Strain	Gene	Zyg	FClass	FTerms	similarity score	p-value	rank	description	GOBP	GOMF	GOCC
YOR207C	RET1	het	FF|FT	NUCLEUS	1	0	1	Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YOR116C	RPO31	het	FF|FT	NUCLEUS	0.431976250132464	1.20247843547236e-152	2	RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YLR243W	GPN3	het	FT	PROTEIN LOCALIZATION	0.423743950389241	2.33832806426356e-146	3	Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p	biological_process	signal sequence binding	cellular_component
YDR527W	RBA50	het	FF|FT	TRANSCRIPTION FROM RNA POL II	0.355719178696445	1.13475040761178e-100	4	Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1	transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YDL150W	RPC53	het	FF|FT	NUCLEUS	0.35506346978459	2.78105733959319e-100	5	RNA polymerase III subunit C53	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YDL152W_d	YDL152W	het	FF		0.343027880367904	2.67696044485385e-93	6	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome	Unknown	Unknown	Unknown
YAL024C	LTE1	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION	0.329784010423742	1.0318533580048e-85	7	Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint|vesicle-mediated transport	guanyl-nucleotide exchange factor activity	cellular bud
YMR185W	RTP1	het			0.305593573675996	1.77412542767325e-73	8	Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene	biological_process	molecular_function	cellular_component
YNL298W	CLA4	hom	FF|FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.287010726609777	1.96814996992247e-64	9	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p	negative regulation of gene expression|vacuole inheritance|protein phosphorylation|budding cell apical bud growth|Rho protein signal transduction|regulation of exit from mitosis|establishment of cell polarity|sterol import|response to pheromone|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	nucleus|cellular bud|fungal-type vacuole
YOR349W	CIN1	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	0.283242790435643	6.003029110984e-63	10	Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl	protein folding|tubulin complex assembly|tubulin complex biogenesis	beta-tubulin binding	cellular_component
YML124C	TUB3	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION|NUCLEUS|CYTOSKELETON	0.275678620231787	1.40381800778921e-59	11	Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication	nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation	structural constituent of cytoskeleton	tubulin complex|cytoplasmic microtubule|kinetochore microtubule|nuclear microtubule|spindle pole body|polar microtubule
YPL241C	CIN2	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON	0.270673478426524	1.95085029947907e-57	12	GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2	protein folding|tubulin complex assembly|tubulin complex biogenesis	GTPase activator activity	cellular_component
YNL221C	POP1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.259034062599704	1.52734065635907e-52	13	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YDR225W	HTA1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME|RSC COMPLEX	0.243604537002348	1.56515507665354e-46	14	Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p	DNA repair|chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter	DNA binding	replication fork protection complex|nuclear nucleosome
YGR083C	GCD2	het	FT	TRANSLATION	0.241734278868199	7.94939604810127e-46	15	Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression	regulation of translational initiation	enzyme regulator activity|guanyl-nucleotide exchange factor activity|translation initiation factor activity	eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YOR260W	GCD1	het	FT	TRANSLATION	0.240622750249213	2.13764008709318e-45	16	Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression	regulation of translational initiation	translation initiation factor activity|guanyl-nucleotide exchange factor activity	eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YER007W	PAC2	hom	FT	CYTOSKELETON	0.236997453235934	4.71432083192823e-44	17	Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl	protein folding|tubulin complex assembly|tubulin complex biogenesis	alpha-tubulin binding	cellular_component
YBR154C	RPB5	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.231540402352493	5.77337062143671e-42	18	RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation	tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YOR262W	GPN2	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION	0.216199432004123	8.6588867282177e-37	19	Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion	establishment of mitotic sister chromatid cohesion	molecular_function	cytoplasm
YNL248C	RPA49	hom	FT	NUCLEUS	0.21156433074943	2.88425725249922e-35	20	RNA polymerase I subunit A49	transcription elongation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size	molecular_function	DNA-directed RNA polymerase I complex
YPR085C	ASA1	het	FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.207871083140655	4.44326417847387e-34	21	Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1	biological_process	molecular_function	ASTRA complex
YBR058C-A	TSC3	hom	FF|FT	KETONE METABOLISM|LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.207311836961512	6.69234764678569e-34	22	Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis	3-keto-sphinganine metabolic process|sphingolipid biosynthetic process	enzyme activator activity	SPOTS complex
YNL148C	ALF1	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEUS|CYTOSKELETON	0.206815642767933	1.12166567921188e-33	23	Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance	protein folding|post-chaperonin tubulin folding pathway	microtubule binding|alpha-tubulin binding	nucleus|cytoplasm
YHR062C	RPP1	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.206317723801841	2.84660988911115e-33	24	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YKL195W	MIA40	het	FF|FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.205278882459359	3.27273483774952e-33	25	Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p	protein import into mitochondrial intermembrane space	molecular_function	mitochondrion|mitochondrial inner membrane|mitochondrial outer membrane translocase complex|mitochondrial intermembrane space
YFL023W	BUD27	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RIBOSOME	0.2047502526966	5.22414295400901e-33	26	Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP	formation of translation preinitiation complex	molecular_function	cytosolic ribosome|cytoplasm
YLR291C	GCD7	het	FT	TRANSLATION|MITOCHONDRION	0.199708106971828	1.55968089233647e-31	27	Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression	regulation of translational initiation	enzyme regulator activity|translation initiation factor activity|guanyl-nucleotide exchange factor activity	mitochondrion|eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YJR049C	UTR1	hom	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM|NUCLEUS	0.197252856782501	8.65530280120317e-31	28	ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication	cellular iron ion homeostasis|NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	nucleus|cytoplasm
YJR043C	POL32	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.186914357178871	9.70969089879191e-28	29	Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p	RNA-dependent DNA replication|lagging strand elongation|postreplication repair|base-excision repair|DNA replication, removal of RNA primer|nucleotide-excision repair|mismatch repair|double-strand break repair via break-induced replication|leading strand elongation	DNA-directed DNA polymerase activity|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity	delta DNA polymerase complex|nucleus
YER165W	PAB1	het	FF|FT	RNA PROCESSING|TRANSLATION|RNA LOCALIZATION|NUCLEUS|RIBOSOME	0.174999519860457	1.73374690299463e-24	30	Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G	regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	poly(A) RNA binding	ribosome|nucleus|cytoplasmic stress granule|cytoplasm
YCL063W	VAC17	hom			0.170763750997315	2.23335820827785e-23	31	Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p	vacuole inheritance	protein anchor	fungal-type vacuole membrane
YOR257W	CDC31	het	FF|FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON|NUCLEAR PORE	0.169261308260994	5.44336005549873e-23	32	Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation	microtubule nucleation|proteasomal ubiquitin-dependent protein catabolic process|spindle pole body duplication associated with nuclear envelope	structural constituent of cytoskeleton	integral to membrane|transcription export complex 2|nucleotide-excision repair factor 2 complex|half bridge of spindle pole body|nuclear pore
YDR211W	GCD6	het	FT	TRANSLATION	0.159356263883583	1.57753987651672e-20	33	Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress	regulation of translational initiation	guanyl-nucleotide exchange factor activity|translation initiation factor activity	eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YAL011W	SWC3	hom	FF|FT	CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.158934077875531	1.99305293998049e-20	34	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae	endoplasmic reticulum organization|chromatin remodeling|histone exchange	molecular_function	mitochondrion|Swr1 complex|nucleus
YJL179W	PFD1	hom	FT	CYTOSKELETON ORGANIZATION	0.151576504255909	1.05839916441614e-18	35	Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin	protein folding|cytoskeleton organization	unfolded protein binding	prefoldin complex
YDR334W	SWR1	hom	FF|FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.149577347142207	3.01251258972589e-18	36	Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A	chromatin remodeling|histone exchange	structural molecule activity	Swr1 complex|nucleus
YER083C	GET2	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.145531216558429	2.39624242017237e-17	37	Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division	retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane	protein anchor	integral to membrane|endoplasmic reticulum|GET complex
YHR025W	THR1	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.145319919420672	2.66606837905299e-17	38	Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway	threonine biosynthetic process|methionine metabolic process|isoleucine metabolic process|homoserine metabolic process	homoserine kinase activity	cellular_component
YDR016C	DAD1	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.144555081511921	3.91777154285946e-17	39	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis	mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization	microtubule binding|structural constituent of cytoskeleton	condensed nuclear chromosome kinetochore|DASH complex|spindle
YOR191W	ULS1	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION	0.13907464907079	5.81703761524587e-16	40	Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress	chromatin assembly or disassembly|mating type switching	SUMO binding|DNA-dependent ATPase activity	mitochondrion|nucleolus|nucleus
YDR076W	RAD55	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.138382663707052	8.11676416405432e-16	41	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p	DNA recombinase assembly|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|protein heterodimerization activity	nucleus|Rhp55-Rhp57 complex
YGR115C_d	YGR115C	het	FF		0.137744401168763	1.13462652133973e-15	42	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C	Unknown	Unknown	Unknown
YOR256C	TRE2	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	0.135124351468733	3.80930996930255e-15	43	Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	molecular_function	cellular_component
YJR139C	HOM6	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS	0.133842958545648	7.59236535028464e-15	44	Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions	threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process	homoserine dehydrogenase activity	nucleus|cytoplasm
YML041C	VPS71	hom	FF|FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|VACUOLAR TRANSPORT|NUCLEUS|CHROMOSOME	0.133296994815604	9.59435568868436e-15	45	Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting	chromatin remodeling|protein targeting to vacuole|histone exchange	nucleosome binding	Swr1 complex|nucleus
YOL005C	RPB11	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.132464474265434	1.32114013419702e-14	46	RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit	termination of RNA polymerase II transcription|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase II, core complex
YJL092W	SRS2	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.131009698069782	2.54551198154896e-14	47	DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability	DNA repair|double-strand break repair via nonhomologous end joining|DNA duplex unwinding	DNA helicase activity	nucleus
YDR004W	RAD57	hom	FF|FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.130256784494556	3.58056725570458e-14	48	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p	DNA recombinase assembly|telomere maintenance via recombination|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|protein heterodimerization activity	nucleus|Rhp55-Rhp57 complex
YGL163C	RAD54	hom	FF|FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS	0.130016851813414	3.99017360952579e-14	49	DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress	positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|DNA translocase activity	nucleus
YKL160W	ELF1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS	0.126567341917404	1.86749784396528e-13	50	Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression	regulation of transcription by chromatin organization|transcription elongation from RNA polymerase II promoter	RNA polymerase II core binding	transcription elongation factor complex|nucleus
YML007W	YAP1	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.125434591259062	3.18972212524838e-13	51	Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|response to heat|response to drug|response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to metal ion	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YJL011C	RPC17	het	FT	NUCLEUS	0.125354959892572	3.14599874088965e-13	52	RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress	transcription initiation from RNA polymerase III promoter|tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YBR231C	SWC5	hom	FF|FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.125144654738977	3.4470080742097e-13	53	Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress	chromatin remodeling|histone exchange	molecular_function	Swr1 complex|nucleus
YFL002C	SPB4	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.122276084245256	1.18060280346326e-12	54	Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients	ribosomal large subunit assembly|rRNA processing	ATP-dependent RNA helicase activity	nucleolus|90S preribosome
YMR283C	RIT1	hom	FT	RNA PROCESSING	0.121469394580727	1.71158709284985e-12	55	2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA	charged-tRNA amino acid modification	transferase activity, transferring pentosyl groups	cytoplasm
YDL059C	RAD59	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.121278341699746	1.84085184745817e-12	56	Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p	DNA strand renaturation|telomere maintenance via recombination|double-strand break repair via break-induced replication|double-strand break repair via single-strand annealing	protein binding	nucleus
YDR413C_d	YDR413C	het			0.120759658221536	2.27126485613664e-12	57	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing	Unknown	Unknown	Unknown
YBR257W	POP4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.119052135622448	4.55299270038131e-12	58	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YOL012C	HTZ1	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.118994677137498	4.66233470294808e-12	59	Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin	nuclear-transcribed mRNA catabolic process, non-stop decay|regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	chromatin binding	nuclear chromatin|chromatin assembly complex
YJL148W	RPA34	hom	FT	NUCLEUS	0.117395860897625	8.98281448096964e-12	60	RNA polymerase I subunit A34.5	transcription elongation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	molecular_function	DNA-directed RNA polymerase I complex|nucleolus|nucleus
YLR085C	ARP6	hom	FF|FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.115873052716957	1.67547093645763e-11	61	Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A	chromatin remodeling|histone exchange	nucleosome binding	Swr1 complex|cytoplasm
YML127W	RSC9	het	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|NUCLEUS|RSC COMPLEX	0.115503436518262	1.93019671936006e-11	62	Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway	G2/M transition of mitotic cell cycle|ATP-dependent chromatin remodeling|nucleosome disassembly|rRNA transcription|regulation of transcription from RNA polymerase II promoter|chromatin remodeling|transcription elongation from RNA polymerase II promoter|response to stress	chromatin binding|DNA translocase activity	RSC complex
YOL006C	TOP1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.114543945379202	2.83133593525053e-11	63	Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination	nuclear migration|chromatin assembly or disassembly|DNA topological change|DNA strand elongation involved in DNA replication|regulation of mitotic recombination|chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|mitotic chromosome condensation|transcription elongation from RNA polymerase II promoter	DNA topoisomerase type I activity	replication fork protection complex|nucleolus|nucleus
YLR033W	RSC58	het	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS|RSC COMPLEX	0.114451538085522	3.03788202624413e-11	64	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance	nucleosome disassembly|transcription elongation from RNA polymerase II promoter|G1/S transition of mitotic cell cycle|chromatin remodeling	molecular_function	RSC complex
YNL216W	RAP1	het	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|GENE SILENCING|NUCLEUS|CHROMOSOME	0.113393872490667	4.46301594739413e-11	65	Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain)	negative regulation of chromatin silencing|establishment of protein localization to chromatin|establishment of chromatin silencing at telomere|regulation of transcription by chromatin organization|protection from non-homologous end joining at telomere|negative regulation of transcription from RNA polymerase II promoter|telomere maintenance via telomere lengthening|telomere maintenance|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|establishment of protein localization to telomere|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	core promoter proximal region sequence-specific DNA binding|DNA binding, bending|sequence-specific DNA binding|TFIID-class transcription factor binding|TBP-class protein binding RNA polymerase II transcription factor activity|telomeric DNA binding|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|G-quadruplex DNA binding|nucleosomal DNA binding	nuclear chromosome|nuclear nucleosome|nuclear chromosome, telomeric region|nuclear telomere cap complex
YDR485C	VPS72	hom	FF|FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.112655027143034	5.96432418085748e-11	66	Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting	chromatin remodeling|histone exchange	histone binding	Swr1 complex|nucleus|cytoplasm
YJL120W_d	YJL120W	hom	FF		0.110818774050314	1.21628954879713e-10	67	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YJR072C	NPA3	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION	0.110522732244881	1.36289800107517e-10	68	Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress	cellular protein complex localization|nucleocytoplasmic transport|mitotic sister chromatid cohesion	ATPase activity|GTPase activity	cytoplasm
YNL112W	DBP2	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION	0.109842051369325	1.82433804177832e-10	69	ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|rRNA processing	RNA helicase activity	mitochondrion|nucleus|cytoplasm
YBR202W	MCM7	het	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME	0.109440612387341	2.06076313634749e-10	70	Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex	S phase of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter|DNA replication initiation|DNA strand elongation involved in DNA replication|DNA unwinding involved in replication|pre-replicative complex assembly|double-strand break repair via break-induced replication|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	DNA replication origin binding|single-stranded DNA-dependent ATPase activity|transcription cofactor activity|single-stranded DNA binding|ATP-dependent 3'-5' DNA helicase activity|ATP binding|four-way junction helicase activity|DNA helicase activity|chromatin binding	replication fork protection complex|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YMR033W	ARP9	het	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RSC COMPLEX	0.107978664465611	3.60147538426844e-10	71	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation	nucleosome positioning|ATP-dependent chromatin remodeling|nucleosome mobilization|chromatin organization|nucleosome disassembly|transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	DNA translocase activity	RSC complex|SWI/SNF complex|nucleus
YFR037C	RSC8	het	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|RSC COMPLEX	0.107975096610923	3.58470499224178e-10	72	Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters	ATP-dependent chromatin remodeling|double-strand break repair via nonhomologous end joining|nucleosome disassembly|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|G1/S transition of mitotic cell cycle	DNA translocase activity|DNA binding	RSC complex|nucleus
YJL039C	NUP192	het	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.106035126219826	7.86192277102309e-10	73	Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205	nucleocytoplasmic transport|nuclear pore organization	structural constituent of nuclear pore	integral to membrane|nuclear pore nuclear basket|nuclear pore|nuclear pore inner ring
YHL031C	GOS1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.103385902205477	1.93574794218991e-09	74	v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28	Golgi vesicle transport|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|Golgi medial cisterna
YIL052C	RPL34B	hom	FF|FT	TRANSLATION|RIBOSOME	0.103124539041359	2.12631428726553e-09	75	Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGL105W	ARC1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.101659150024032	3.58430004802382e-09	76	Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress	positive regulation of ligase activity|tRNA aminoacylation for protein translation	enzyme activator activity|tRNA binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding	methionyl glutamyl tRNA synthetase complex|cytoplasm
YGL020C	GET1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS	0.100991593988794	4.53594690613633e-09	77	Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance	retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane	protein anchor	mitochondrion|integral to membrane|endoplasmic reticulum|GET complex
YBL092W	RPL32	het	FF|FT	TRANSLATION|RIBOSOME	0.100807692086192	5.01974472132331e-09	78	Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YHR179W	OYE2	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEUS|MITOCHONDRION	0.0996910532056238	7.14535989743473e-09	79	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress	apoptotic process	NADPH dehydrogenase activity	mitochondrion|nucleus|cytoplasm
YGL175C	SAE2	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.09898954894486	9.34216109021033e-09	80	Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents	DNA double-strand break processing|DNA catabolic process, endonucleolytic|meiotic DNA double-strand break formation|meiotic DNA double-strand break processing|gene conversion at mating-type locus, DNA double-strand break processing	double-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity	nucleus|cytoplasm
YKL144C	RPC25	het	FT	NUCLEUS	0.0987919299517711	9.7503016548963e-09	81	RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p	transcription initiation from RNA polymerase III promoter|tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YBR091C	TIM12	het	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0983818252534531	1.12253117320865e-08	82	Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins	protein import into mitochondrial inner membrane	phospholipid binding|protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YNL114C_d	YNL114C	het			0.0973146551697501	1.61528663354194e-08	83	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit	Unknown	Unknown	Unknown
YLR355C	ILV5	het	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0965199144016552	2.11287128563758e-08	84	Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids	mitochondrial genome maintenance|branched-chain amino acid biosynthetic process	double-stranded DNA binding|ketol-acid reductoisomerase activity	mitochondrial nucleoid|mitochondrion
YDR439W	LRS4	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME|KINETOCHORE	0.096376237384218	2.21747348037813e-08	85	Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation	rDNA condensation|chromatin silencing at rDNA|homologous chromosome segregation|protein localization to nucleolar rDNA repeats	molecular_function	nucleolus|nucleus|monopolin complex
YJR104C	SOD1	hom	FF|FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|MITOCHONDRION	0.0963190922403051	2.27133804252949e-08	86	Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid	cellular copper ion homeostasis|fungal-type cell wall organization|superoxide metabolic process|cellular zinc ion homeostasis|positive regulation of sequence-specific DNA binding transcription factor activity|age-dependent response to reactive oxygen species involved in chronological cell aging	superoxide dismutase activity	cytosol|mitochondrion|nucleus|mitochondrial intermembrane space
YHR163W	SOL3	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0951165320107829	3.86876071804264e-08	87	6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	6-phosphogluconolactonase activity	nucleus|cytoplasm
YOR236W	DFR1	het	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.0926981014715542	7.46188604746797e-08	88	Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism	tetrahydrofolate biosynthetic process|dihydrofolate metabolic process	dihydrofolate reductase activity|mRNA binding	cytosol
YER107C	GLE2	hom	FF|FT	PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0914641401666434	1.10978892296957e-07	89	RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1	poly(A)+ mRNA export from nucleus|Unknown|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear pore distribution|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	molecular_function	integral to membrane|nuclear pore|cytoplasm
YKL056C	TMA19	hom	FT	TRANSLATION|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION|CYTOSKELETON	0.0913948127429032	1.13464573843744e-07	90	Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress	cytoplasmic translation|cellular response to oxidative stress	molecular_function	cytosol|mitochondrion|ribosome|cytoplasm
YBR216C	YBP1	hom	FT	RESPONSE TO OXIDATIVE STRESS	0.0911802225660472	1.22029938747325e-07	91	Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication	cellular response to oxidative stress	molecular_function	cytoplasm
YPR034W	ARP7	het	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RSC COMPLEX	0.0908424859055358	1.35285866956829e-07	92	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation	nucleosome mobilization|ATP-dependent chromatin remodeling|chromatin organization|nucleosome disassembly|transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	DNA translocase activity	RSC complex|SWI/SNF complex|nucleus
YBL026W	LSM2	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0905861506118828	1.46742473737945e-07	93	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|cytoplasmic mRNA processing body|U4/U6 x U5 tri-snRNP complex
YNR016C	ACC1	het	FF|FT	PROTEIN LOCALIZATION|KETONE METABOLISM|LIPID METABOLISM|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0904731058929761	1.52087843314503e-07	94	Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;	nuclear envelope organization|protein import into nucleus|fatty acid biosynthetic process	biotin carboxylase activity|acetyl-CoA carboxylase activity	mitochondrion|endoplasmic reticulum membrane
YMR016C	SOK2	hom	FT	NUCLEUS	0.090466468483369	1.52407478209855e-07	95	Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication	pseudohyphal growth	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YOR020C	HSP10	het	FT	MITOCHONDRION	0.0901358988789477	1.69174780786512e-07	96	Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES	protein folding|protein refolding	unfolded protein binding|chaperone binding	mitochondrion|mitochondrial matrix
YGL093W	SPC105	het	FF|FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.0889081705061897	2.50536344765678e-07	97	Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components	microtubule nucleation|protein localization to kinetochore|sister chromatid biorientation|mitotic cell cycle spindle assembly checkpoint	microtubule binding|structural constituent of cytoskeleton	mitochondrion|condensed nuclear chromosome kinetochore|spindle pole body
YBL105C	PKC1	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0881273602704233	3.22942015450855e-07	98	Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)	intracellular protein kinase cascade|regulation of nuclear-transcribed mRNA poly(A) tail shortening|fungal-type cell wall organization|signal transduction|actin filament organization|peroxisome degradation|protein phosphorylation|cytoplasmic mRNA processing body assembly	protein kinase C activity	site of polarized growth|cytoskeleton|nucleus|plasma membrane|cytoplasm
YMR274C	RCE1	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0868909959276665	4.71445401133716e-07	99	Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone	CAAX-box protein processing|peptide pheromone maturation|protein processing	metalloendopeptidase activity	integral to endoplasmic reticulum membrane|integral to membrane
YDL101C	DUN1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0864153625193936	5.3408887271719e-07	100	Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair	protein phosphorylation|replication fork protection|cell cycle checkpoint|DNA damage checkpoint	protein kinase activity	nucleus
YER095W	RAD51	hom	FF|FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0849324510986968	8.33766346699134e-07	101	Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein	strand invasion|telomere maintenance via recombination|heteroduplex formation|meiotic joint molecule formation|reciprocal meiotic recombination|double-strand break repair via single-strand annealing	recombinase activity|single-stranded DNA binding|DNA-dependent ATPase activity	condensed nuclear chromosome|nuclear chromosome
YOR210W	RPB10	het	FF|FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0841011447786659	1.0668288637439e-06	102	RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III	transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase II, core complex
YHR034C	PIH1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0831316767916043	1.42828032828563e-06	103	Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II	protein folding|rRNA processing|regulation of cell size|box C/D snoRNP assembly	molecular_function	R2TP complex|nucleus|small nucleolar ribonucleoprotein complex|cytoplasm
YHR031C	RRM3	hom	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|NUCLEUS|CHROMOSOME	0.083003345464527	1.50962608028691e-06	104	DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p	mitochondrial genome maintenance|replication fork progression beyond termination site|DNA replication	ATP-dependent DNA helicase activity|DNA helicase activity	nuclear telomeric heterochromatin|replication fork
YNL250W	RAD50	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION	0.082994892049842	1.49173949359607e-06	105	Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress	base-excision repair|meiotic DNA double-strand break processing|telomere maintenance via recombination|meiosis|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|negative regulation of endodeoxyribonuclease activity	double-stranded DNA binding|single-stranded telomeric DNA binding|ATPase activity|double-stranded telomeric DNA binding|G-quadruplex DNA binding|telomeric DNA binding|adenylate kinase activity	mitochondrion|nucleus|Mre11 complex
YOR264W	DSE3	hom	FT	CELL CYCLE|SITE OF POLARIZED GROWTH	0.0825887231055238	1.6607591140103e-06	106	Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cellular bud neck
YGR090W	UTP22	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0819587584354422	2.01358396807963e-06	107	Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	molecular_function	small-subunit processome|nucleolus|nucleus|UTP-C complex|90S preribosome|CURI complex
YJL121C	RPE1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	0.0819524555140111	1.9961239050852e-06	108	D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress	pentose-phosphate shunt	ribulose-phosphate 3-epimerase activity	cytosol
YGR113W	DAM1	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.0819425327181927	2.02300809783071e-06	109	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments	mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization	microtubule binding|structural constituent of cytoskeleton	spindle midzone|DASH complex|condensed nuclear chromosome kinetochore|kinetochore microtubule|spindle
YCL030C	HIS4	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0813823441515891	2.3510908118755e-06	110	Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis	histidine biosynthetic process	phosphoribosyl-ATP diphosphatase activity|phosphoribosyl-AMP cyclohydrolase activity|histidinol dehydrogenase activity	intracellular
YNR050C	LYS9	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0800012645135544	3.47962732282754e-06	111	Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112	lysine biosynthetic process via aminoadipic acid	saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity	cytoplasm
YMR038C	CCS1	hom	FF|FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|MITOCHONDRION	0.0790540265269308	4.78047581149809e-06	112	Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress	intracellular copper ion transport	superoxide dismutase copper chaperone activity	cytosol|mitochondrial inner membrane|nucleus
YER039C-A_p	YER039C-A	hom			0.0788615328967731	4.78614890143173e-06	113	Putative protein of unknown function; YER039C-A is not an essential gene	biological_process	molecular_function	integral to membrane
YHR206W	SKN7	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0787563415289619	4.96012517151508e-06	114	Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; SKN7 has a paralog, HMS2, that arose from the whole genome duplication	response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|transcription, DNA-dependent|response to osmotic stress|regulation of cell size	sequence-specific DNA binding|two-component response regulator activity|sequence-specific DNA binding transcription factor activity	nucleus
YML081W	TDA9	hom	FT	NUCLEUS	0.0785407845255542	5.23137205106877e-06	115	DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication	biological_process	sequence-specific DNA binding	nucleus
YBR002C	RER2	het	FF|FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0779322244339588	6.28660503921453e-06	116	Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting	dolichol biosynthetic process|protein glycosylation|ER to Golgi vesicle-mediated transport	dehydrodolichyl diphosphate synthase activity|prenyltransferase activity	endoplasmic reticulum
YJL081C	ARP4	het	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME|HISTONE ACETYLTRANSFERASE	0.0777734684795391	6.67117377409224e-06	117	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes	DNA repair|histone acetylation|kinetochore assembly|chromatin organization|regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|chromatin remodeling	chromatin binding|histone acetyltransferase activity|ATP-dependent 3'-5' DNA helicase activity	nuclear chromatin|Swr1 complex|nucleus|Ino80 complex|NuA4 histone acetyltransferase complex
YCL037C	SRO9	hom	FT	TRANSLATION	0.0776658333606097	6.65646419204061e-06	118	Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication	cytoplasmic translation	RNA binding	polysome
YJL015C_d	YJL015C	het			0.0776045066552938	6.8336069663788e-06	119	Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W	Unknown	Unknown	Unknown
YPL161C	BEM4	hom	FF|FT	SIGNALING|CYTOSKELETON ORGANIZATION|NUCLEUS	0.0770782951904175	7.81428565781668e-06	120	Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length	establishment of cell polarity|Rho protein signal transduction|actin cytoskeleton organization	molecular_function	nucleus|cytoplasm
YOR309C_d	YOR309C	hom			0.0768965597048291	8.20979288563165e-06	121	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58	Unknown	Unknown	Unknown
YML101C	CUE4	hom	FT	ENDOPLASMIC RETICULUM	0.0767747844040444	8.48543467799798e-06	122	Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication	biological_process	molecular_function	endoplasmic reticulum|cytoplasm
YNL239W	LAP3	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS|MITOCHONDRION	0.0767426164201405	8.55971095240504e-06	123	Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH	response to antibiotic|negative regulation of transcription from RNA polymerase II promoter|homocysteine catabolic process	double-stranded DNA binding|cysteine-type peptidase activity|mRNA binding|single-stranded DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	mitochondrion|cytoplasm
YPR107C	YTH1	het	FF|FT	RNA PROCESSING|NUCLEUS	0.0762704812556801	9.87356934094271e-06	124	Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation	mRNA cleavage|mRNA polyadenylation	RNA binding	mRNA cleavage and polyadenylation specificity factor complex
YPR074C	TKL1	hom	FF|FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	0.075942875782007	1.06190510179381e-05	125	Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication	pentose-phosphate shunt	transketolase activity	cytoplasm
YNL313C	EMW1	het	FT	CELL WALL ORG/BIOGENESIS|NUCLEUS	0.0758342643539142	1.09658541750392e-05	126	Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress	fungal-type cell wall organization	molecular_function	nucleus|cytoplasm
YKL111C_d	YKL111C	het			0.0757529849935128	1.11733311012686e-05	127	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified essential gene ABF1	Unknown	Unknown	Unknown
YNL075W	IMP4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0754218964641713	1.22064005306277e-05	128	Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs	rRNA processing	snoRNA binding|single-stranded telomeric DNA binding|rRNA primary transcript binding	small-subunit processome|Mpp10 complex|90S preribosome
YCL031C	RRP7	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0750827750762775	1.3358653829405e-05	129	Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress	ribosomal small subunit assembly|rRNA processing	molecular_function	nucleolus|nucleus|UTP-C complex|CURI complex
YLR402W_d	YLR402W	hom			0.0750533063617036	1.3543502465843e-05	130	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL020C	RPN4	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS	0.0749423821775572	1.43231515463717e-05	131	Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|regulation of DNA repair|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YER005W	YND1	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|GOLGI APPARATUS	0.07488750150817	1.40684541849717e-05	132	Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity	protein glycosylation	nucleoside-triphosphatase activity|nucleoside-diphosphatase activity	COPI-coated vesicle|Golgi apparatus|membrane|Golgi membrane
YNL108C_p	YNL108C	hom	FT	NUCLEUS	0.0742515886502585	1.66375524288432e-05	133	Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YHR193C	EGD2	hom	FT	PROTEIN LOCALIZATION|NUCLEUS	0.0740948967233469	1.73861998292528e-05	134	Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes	'de novo' cotranslational protein folding	unfolded protein binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding	nascent polypeptide-associated complex
YAL012W	CYS3	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0740039516098313	1.83260648849476e-05	135	Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress	sulfur amino acid metabolic process|cysteine biosynthetic process|cysteine biosynthetic process via cystathionine|transsulfuration|cysteine metabolic process	cystathionine gamma-lyase activity	cytoplasm
YKL089W	MIF2	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE	0.0729974135714224	2.30712376870089e-05	136	Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3	chromosome segregation|mitotic spindle organization in nucleus	centromeric DNA binding	condensed nuclear chromosome, centromeric region|condensed nuclear chromosome inner kinetochore
YDR121W	DPB4	hom	FT	GENE SILENCING|NUCLEUS|CHROMOSOME	0.072699132992972	2.51269039402513e-05	137	Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization	DNA-dependent DNA replication|chromatin silencing at telomere	double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity	chromatin accessibility complex|epsilon DNA polymerase complex
YGL048C	RPT6	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS	0.0723576565454421	2.7204250041589e-05	138	ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress	proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|nucleotide-excision repair|proteasome regulatory particle assembly|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of sequence-specific DNA binding transcription factor activity|chromatin remodeling	ATPase activity|protein domain specific binding	proteasome regulatory particle, base subcomplex|proteasome storage granule|nucleus
YLR163C	MAS1	het	FF|FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0722638718569345	2.84869679044987e-05	139	Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins	protein processing involved in protein targeting to mitochondrion	metalloendopeptidase activity	mitochondrion|mitochondrial processing peptidase complex
YGR163W	GTR2	hom	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION|NUCLEUS|CHROMOSOME	0.0712396663936217	3.61666527120248e-05	140	Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD	microautophagy|positive regulation of transcription from RNA polymerase II promoter	GTP binding	nuclear chromatin|fungal-type vacuole membrane|integral to membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YCR075W-A_p	YCR075W-A	hom			0.0709798026431479	3.86190017991997e-05	141	Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLR200W	YKE2	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEUS	0.0697732060097083	5.2221348676309e-05	142	Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin	protein folding|tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YDR468C	TLG1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|GOLGI APPARATUS	0.0693681216751383	5.77275318122774e-05	143	Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p	endocytosis|vesicle fusion	SNAP receptor activity	trans-Golgi network|SNARE complex|endosome
YPL266W	DIM1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0692032951420649	6.01216443203598e-05	144	Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing	rRNA modification|rRNA processing	rRNA (adenine-N6,N6-)-dimethyltransferase activity	nucleolus|90S preribosome
YIL164C	NIT1	hom			0.0685535374845578	7.06818959618158e-05	145	Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene	biological_process	nitrilase activity	cellular_component
YGL043W	DST1	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|NUCLEUS	0.0676288063239578	8.82431561352956e-05	146	General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress	transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|mRNA cleavage|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|tRNA transcription from RNA polymerase III promoter|regulation of mRNA 3'-end processing|positive regulation of transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|transcription antitermination|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter	RNA polymerase II regulatory region DNA binding|RNA polymerase II core binding|core RNA polymerase II recruiting transcription factor activity	nucleus
YHL034C	SBP1	hom	FT	TRANSLATION|NUCLEUS	0.0675462334613621	9.00170075144729e-05	147	Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11	negative regulation of translation|negative regulation of translation in response to stress	RNA binding|eukaryotic initiation factor 4G binding	nucleolus|cytoplasmic mRNA processing body|cytoplasm
YDR540C	IRC4	hom	FF|FT	NUCLEUS	0.0673848188580248	9.35822300420059e-05	148	Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	mitotic recombination	molecular_function	nucleus|cytoplasm
YKR025W	RPC37	het	FT	NUCLEUS	0.0671285108406308	9.97568616859154e-05	149	RNA polymerase III subunit C37	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YEL034W	HYP2	het	FF|FT	KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION|RIBOSOME	0.0670221711377566	0.000102817263893442	150	Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication	positive regulation of translational initiation|translational frameshifting|positive regulation of translational termination|positive regulation of translational elongation	ribosome binding|RNA binding|translation elongation factor activity|translation initiation factor activity	mitochondrion|cytosolic ribosome|cytoplasm
YBR152W	SPP381	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0667001293110016	0.000110240327971993	151	mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p	mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step	molecular_function	U4/U6 x U5 tri-snRNP complex
YPL061W	ALD6	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.0666851313181381	0.000110634757481518	152	Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress	response to salt stress|NADPH regeneration|acetate biosynthetic process	aldehyde dehydrogenase [NAD(P)+] activity	cytosol|mitochondrion
YLR081W	GAL2	hom	FT	CARBOHYDRATE METABOLISM|PLASMA MEMBRANE	0.0665077946936981	0.000115400524179572	153	Galactose permease, required for utilization of galactose; also able to transport glucose	galactose transport|galactose metabolic process	galactose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YPR187W	RPO26	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0662327664840081	0.000123176170795839	154	RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit	tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YBL099W	ATP1	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION	0.0660007885554598	0.000130417620225575	155	Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrial nucleoid|proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, catalytic core
YOR295W	UAF30	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS	0.0654779812999973	0.000148139984788295	156	Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|chromatin organization	RNA polymerase I upstream control element sequence-specific DNA binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity	nucleolus|RNA polymerase I upstream activating factor complex
YGR092W	DBF2	hom	FF|FT	CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0652652229969167	0.000154986362148021	157	Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis	nuclear division|protein phosphorylation|vacuolar acidification	protein serine/threonine kinase activity|protein kinase activity	spindle pole body|cellular bud neck
YLR321C	SFH1	het	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|RSC COMPLEX	0.0650999099193206	0.000161077630880796	158	Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog	ATP-dependent chromatin remodeling|double-strand break repair|chromosome segregation|regulation of DNA replication involved in S phase|chromatin remodeling at centromere|nucleosome disassembly|G2/M transition of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	DNA translocase activity	RSC complex
YBL039C	URA7	hom	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM	0.0647119745098612	0.000177847819275722	159	Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication	pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process	CTP synthase activity	cytosol
YOR318C_d	YOR318C	hom			0.0645313419020882	0.000183790766690164	160	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo	Unknown	Unknown	Unknown
YJL111W	CCT7	het	FF		0.0645303962048667	0.000183423398332477	161	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance	protein folding	unfolded protein binding	chaperonin-containing T-complex|cytoplasm
YPR161C	SGV1	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0639609763434534	0.000209117792265778	162	Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins	phosphorylation of RNA polymerase II C-terminal domain|protein phosphorylation|transcription, DNA-dependent|positive regulation of histone H3-K4 methylation	RNA polymerase II carboxy-terminal domain kinase activity|cyclin-dependent protein kinase activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YBR192W	RIM2	het	FF|FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.0638506061077779	0.000214473889062094	163	Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family	pyrimidine nucleotide transport|mitochondrial genome maintenance|transmembrane transport	pyrimidine nucleotide transmembrane transporter activity|transporter activity	mitochondrion|integral to membrane
YPL054W	LEE1	hom			0.0633935511730091	0.000238054710010777	164	Zinc-finger protein of unknown function	biological_process	molecular_function	cellular_component
YKL131W_d	YKL131W	hom			0.0632526013180427	0.000245803778815375	165	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR277W	FCP1	het	FF|FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0628604317371556	0.000269194990679442	166	Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)	dephosphorylation of RNA polymerase II C-terminal domain|regulation of transcription from RNA polymerase II promoter	protein serine/threonine phosphatase activity	nucleus
YOL067C	RTG1	hom	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|NUCLEUS	0.0623738605923509	0.000299705671067985	167	Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus	cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus|cytoplasm
YDL060W	TSR1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.062196073366083	0.000311878202079912	168	Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress	rRNA processing|ribosome biogenesis	ribonucleoprotein complex binding	nucleolus|cytoplasm|90S preribosome
YML103C	NUP188	hom	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0620032105625666	0.000325605232946464	169	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188	nuclear pore organization|protein import into nucleus|mRNA export from nucleus in response to heat stress	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YLR087C	CSF1	hom	FF|FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0619887881671873	0.000328676104401266	170	Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	fermentation	molecular_function	mitochondrion
YFR004W	RPN11	het	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION|NUCLEUS|MITOCHONDRION	0.0618631980248917	0.000344991939963866	171	Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress	protein deubiquitination|proteasomal ubiquitin-dependent protein catabolic process|peroxisome fission|mitochondrial fission	metallopeptidase activity|ubiquitin-specific protease activity	cytosol|mitochondrion|proteasome storage granule|nucleus|proteasome regulatory particle, lid subcomplex
YFR018C_p	YFR018C	hom	FT	PROTEOLYSIS	0.0618199488079519	0.000339170805793813	172	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR333C_d	YOR333C	hom			0.0614907186381665	0.000364878010261497	173	Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth	Unknown	Unknown	Unknown
YPR120C	CLB5	hom	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0614522668188788	0.000367996427000158	174	B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase	spindle assembly|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation|premeiotic DNA replication|positive regulation of DNA replication	cyclin-dependent protein kinase regulator activity	nucleus
YOR258W	HNT3	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0613607148198854	0.000375521761448621	175	DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress	response to DNA damage stimulus	DNA 5'-adenosine monophosphate hydrolase activity	nucleus|cytoplasm
YPL014W_p	YPL014W	hom	FT	NUCLEUS	0.0609190058063186	0.000413892347185521	176	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YPL122C	TFB2	het	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME	0.0606766295398753	0.00043647251763601	177	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	double-stranded DNA binding|core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YDR088C	SLU7	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0605793650849128	0.000448495223418204	178	RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain	generation of catalytic spliceosome for second transesterification step	second spliceosomal transesterification activity	spliceosomal complex
YIL126W	STH1	het	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|RSC COMPLEX	0.0602138770251282	0.000483749831309567	179	ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p	double-strand break repair|ATP-dependent chromatin remodeling|nucleosome positioning|chromosome segregation|chromatin remodeling at centromere|nucleosome disassembly|regulation of transcription, DNA-dependent|G2/M transition of mitotic cell cycle|meiosis|cytoskeleton organization|transcription elongation from RNA polymerase II promoter	histone acetyl-lysine binding|DNA translocase activity|helicase activity|DNA-dependent ATPase activity	RSC complex|nucleus
YEL044W	IES6	hom	FT	NUCLEUS	0.0598734994185966	0.000522788387275507	180	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes	biological_process	molecular_function	nucleus
YIL142W	CCT2	het			0.0594543814884274	0.000568915032790636	181	Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	protein folding	unfolded protein binding	chaperonin-containing T-complex|cytoplasm
YNL225C	CNM67	hom	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	0.0590399394741944	0.000622897677852642	182	Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication	microtubule nucleation|mitotic spindle organization	structural constituent of cytoskeleton	outer plaque of spindle pole body|spindle pole body
YJR032W	CPR7	hom			0.0585175610925601	0.000694797055350653	183	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity	protein refolding|response to stress	unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity	cytosol
YOR141C	ARP8	hom	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME|CYTOSKELETON	0.0583637631118548	0.000717783507348799	184	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity	mitotic recombination|response to DNA damage stimulus|chromatin remodeling	mRNA binding|ATP-dependent 3'-5' DNA helicase activity	nucleus|Ino80 complex
YGR029W	ERV1	het	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.0582638799657586	0.000733088069704799	185	Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)	cellular response to oxidative stress|cellular iron ion homeostasis|protein import into mitochondrial intermembrane space	thiol oxidase activity|flavin-linked sulfhydryl oxidase activity	mitochondrion|mitochondrial intermembrane space
YLR197W	NOP56	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0578408151916778	0.000808599385387188	186	Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects	rRNA modification|rRNA processing	molecular_function	box C/D snoRNP complex|small-subunit processome|nucleolus|nucleus|90S preribosome
YDL143W	CCT4	het	FF		0.0577498846272104	0.000816749099461554	187	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	protein folding	unfolded protein binding	chaperonin-containing T-complex
YLR424W	SPP382	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS|MITOCHONDRION	0.0577218189415124	0.000821562860490099	188	Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation	spliceosomal complex disassembly|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step	RNA binding|ATP-dependent RNA helicase activity	mitochondrion|U2-type post-mRNA release spliceosomal complex|nucleus|spliceosomal complex|cytoplasm
YPR061C	JID1	hom	FT	MITOCHONDRION	0.0576189624138818	0.000839430369158437	189	Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae	biological_process	molecular_function	mitochondrion
YOR159C	SME1	het	FT	RNA PROCESSING|NUCLEUS	0.0576162506111283	0.000839906282489521	190	Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E	mRNA splicing, via spliceosome	molecular_function	U1 snRNP|U2-type prespliceosome|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YPL029W	SUV3	hom	FF|FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION|MITOCHONDRION|CHROMOSOME	0.0574326454986896	0.000872716477709314	191	ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron	mitochondrial DNA replication|mitochondrial RNA catabolic process|Group I intron splicing	exoribonuclease II activity|ATP-dependent RNA helicase activity	mitochondrion|mitochondrial chromosome|mitochondrial degradosome
YMR275C	BUL1	hom	FT	MITOCHONDRION ORGANIZATION|PLASMA MEMBRANE|UBIQUITIN LIGASE COMPLEX	0.0573655265832395	0.000885004225127522	192	Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication	mitochondrion inheritance|protein monoubiquitination|protein polyubiquitination	ubiquitin-ubiquitin ligase activity	ubiquitin ligase complex|plasma membrane
YPL062W_d	YPL062W	hom			0.0572105849800205	0.000920474869491821	193	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation	Unknown	Unknown	Unknown
YPL110C	GDE1	hom	FT	LIPID METABOLISM|SIGNALING|CARBOHYDRATE METABOLISM	0.0570607771726735	0.00094283864736666	194	Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes	glycerophospholipid catabolic process	glycerophosphocholine phosphodiesterase activity	ribosome|cytoplasm
YGL072C_d	YGL072C	hom	FF		0.0569396006923353	0.000966792559031038	195	Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	Unknown	Unknown	Unknown
YIL106W	MOB1	het	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON	0.0568655076001868	0.000981715390647401	196	Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress	regulation of exit from mitosis|protein phosphorylation	kinase regulator activity	spindle pole body|cellular bud neck
YCR053W	THR4	hom	FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|AMINO ACID METABOLISM|NUCLEUS	0.0568514002837297	0.000996703940227666	197	Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway	endocytosis|threonine metabolic process	threonine synthase activity	nucleus|cytoplasm
YDL214C	PRR2	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0568093637316634	0.0010053766707404	198	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance	negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation	protein kinase activity|receptor signaling protein serine/threonine kinase activity	nucleus
YKL024C	URA6	het	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.0566115249296861	0.00103450220849726	199	Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)	'de novo' pyrimidine nucleobase biosynthetic process|nucleobase-containing compound metabolic process	uridylate kinase activity|adenylate kinase activity	nucleus|cytoplasm
YFR036W	CDC26	hom	FF|FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0564904289747864	0.00106058389221618	200	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YBR140C	IRA1	het	FF|FT	SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE	0.0562212438325741	0.00112075380822331	201	GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication	negative regulation of cAMP biosynthetic process|negative regulation of Ras protein signal transduction|regulation of adenylate cyclase activity|positive regulation of Ras GTPase activity	Ras GTPase activator activity	mitochondrion|integral to membrane|membrane
YNL107W	YAF9	hom	FF|FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME|HISTONE ACETYLTRANSFERASE	0.056146027989027	0.00113812177213195	202	Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain	DNA repair|chromatin remodeling|histone exchange|chromatin silencing at telomere	molecular_function	Swr1 complex|nucleus|NuA4 histone acetyltransferase complex|cytoplasm
YDR212W	TCP1	het			0.0560918917800318	0.00115077581564193	203	Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein	protein folding	unfolded protein binding	plasma membrane|chaperonin-containing T-complex
YDR145W	TAF12	het	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE	0.0558644327066709	0.00120537640664914	204	Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A	histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter	TBP-class protein binding|chromatin binding|RNA polymerase II activating transcription factor binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YPR086W	SUA7	het	FT	TRANSCRIPTION FROM RNA POL II|TRANSLATION|NUCLEUS	0.0558425305493317	0.00122103665399684	205	Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II	transcriptional start site selection at RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|Unknown	TBP-class protein binding|RNA polymerase II core binding|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|core RNA polymerase II recruiting transcription factor activity	nucleus
YJR007W	SUI2	het	FF|FT	TRANSLATION|RIBOSOME	0.0558127476246414	0.00122429989208682	206	Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress	translational initiation	translation initiation factor activity	ribosome|multi-eIF complex|eukaryotic translation initiation factor 2 complex|cytoplasm
YOL062C	APM4	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE	0.055650382139864	0.00126104998057553	207	Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport	intracellular protein transport|vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YDR449C	UTP6	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0551523589786304	0.00139445223907086	208	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YIL009C-A	EST3	hom	FT	NUCLEUS|CHROMOSOME	0.0549038113831927	0.00146338857541459	209	Component of the telomerase holoenzyme, involved in telomere replication	telomere maintenance via telomerase	ATP-dependent DNA/RNA helicase activity|GTPase activity|telomeric DNA binding	chromosome, telomeric region|nucleus|telomerase holoenzyme complex
YPR071W_p	YPR071W	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0548361208608355	0.00148336342719876	210	Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C	biological_process	molecular_function	integral to membrane
YPR088C	SRP54	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS	0.0547251906625067	0.00151664158656979	211	Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|SRP-dependent cotranslational protein targeting to membrane|protein targeting to ER	7S RNA binding|GTP binding|signal sequence binding	signal recognition particle, endoplasmic reticulum targeting
YJR013W	GPI14	het	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0545765445810878	0.0015623122524331	212	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M	fungal-type cell wall organization|GPI anchor biosynthetic process	mannosyltransferase activity	integral to membrane|endoplasmic reticulum membrane
YER019W	ISC1	hom	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0544635743876067	0.0016004449333715	213	Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance	response to salt stress|ceramide biosynthetic process|sphingolipid catabolic process	inositol phosphosphingolipid phospholipase activity	mitochondrion|endoplasmic reticulum|integral to mitochondrial outer membrane
YDR187C_d	YDR187C	het	FF		0.0544408711278265	0.00160509864748886	214	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W	Unknown	Unknown	Unknown
YDR102C_d	YDR102C	hom			0.0543698560223232	0.00162792157440775	215	Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index	Unknown	Unknown	Unknown
YPR190C	RPC82	het	FT	NUCLEUS	0.054231614144036	0.00167588892983428	216	RNA polymerase III subunit C82	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YER013W	PRP22	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0541871469542384	0.00169072001100472	217	DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes	spliceosomal complex disassembly|generation of catalytic spliceosome for second transesterification step	second spliceosomal transesterification activity|ATP-dependent RNA helicase activity	U2-type post-spliceosomal complex|U2-type catalytic step 2 spliceosome
YJR065C	ARP3	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.054168609795479	0.00169422982802982	218	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity	mitochondrion inheritance|Arp2/3 complex-mediated actin nucleation|actin filament organization	ATP binding	Arp2/3 protein complex|plasma membrane
YKL025C	PAN3	hom	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	0.0539400176018438	0.00177255525758918	219	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes	DNA repair|mRNA 3'-end processing|postreplication repair	poly(A)-specific ribonuclease activity	PAN complex|cytoplasm
YGR171C	MSM1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION	0.0534164393449606	0.00196465052323604	220	Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p	methionyl-tRNA aminoacylation	methionine-tRNA ligase activity	mitochondrion
YJL096W	MRPL49	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0531736128350298	0.00206007067749339	221	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGL252C	RTG2	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|SIGNALING|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|CHROMOSOME|HISTONE ACETYLTRANSFERASE	0.0530663665857743	0.00210355149742045	222	Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p	maintenance of DNA trinucleotide repeats|regulation of transcription from RNA polymerase II promoter|Unknown|nitrogen catabolite regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway|transcription factor import into nucleus	RNA polymerase II transcription factor binding transcription factor activity	SLIK (SAGA-like) complex|transcriptionally active chromatin|cytoplasm
YGR276C	RNH70	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0530318689498817	0.00212749415832945	223	3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts	U5 snRNA 3'-end processing|generation of mature 3'-end of 5S rRNA generated by RNA polymerase III|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|tRNA 3'-trailer cleavage, exonucleolytic	3'-5'-exoribonuclease activity|3'-5' exonuclease activity	nucleus
YIL104C	SHQ1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEUS	0.0529536460430575	0.00215345245813829	224	Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones	box H/ACA snoRNP assembly	unfolded protein binding	nucleoplasm
YGR167W	CLC1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE	0.0528391360691143	0.00220855290024927	225	Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W	endocytosis|vesicle-mediated transport	structural molecule activity	clathrin vesicle coat
YCL012C	YCL012C	hom			0.0527336850490267	0.00227473935750673	226	Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene	biological_process	molecular_function	cellular_component
YNR048W	YNR048W	hom			0.0524496078773251	0.00237035695666111	227	Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication	response to drug	phospholipid-translocating ATPase activity	integral to membrane
YDR369C	XRS2	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.0523976422565555	0.00239419514554475	228	Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling	double-strand break repair via nonhomologous end joining|meiotic DNA double-strand break formation|base-excision repair|telomere maintenance|sporulation resulting in formation of a cellular spore|double-strand break repair via break-induced replication	single-stranded telomeric DNA binding|protein binding, bridging|DNA binding|double-stranded telomeric DNA binding|telomeric DNA binding|G-quadruplex DNA binding	nucleus|Mre11 complex
YMR089C	YTA12	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0521710616027434	0.0025007192716529	229	Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes	proteolysis|signal peptide processing|protein complex assembly|protein import into mitochondrial intermembrane space	metallopeptidase activity|protein binding|ATPase activity|ATP binding	mitochondrion|mitochondrial inner boundary membrane|mitochondrial inner membrane|m-AAA complex|cytoplasm
YMR182W-A_p	YMR182W-A	hom			0.0519538039102692	0.00260691307461001	230	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR055C	SPT8	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0517619961402037	0.00270407540339396	231	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters	histone acetylation|negative regulation of transcription from RNA polymerase II promoter|chromatin modification|positive regulation of transcription from RNA polymerase II promoter	TBP-class protein binding|transcription cofactor activity	nucleus|SAGA complex
YNL131W	TOM22	het	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0516669677522463	0.00275342829105037	232	Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes	protein import into mitochondrial matrix|protein import into mitochondrial outer membrane	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YIL136W	OM45	hom	FT	MITOCHONDRION	0.0515613997858351	0.00280921824997244	233	Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YFL022C	FRS2	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.0513812807159502	0.00290679366296149	234	Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar	phenylalanyl-tRNA aminoacylation	phenylalanine-tRNA ligase activity	phenylalanine-tRNA ligase complex|cytoplasm
YHR166C	CDC23	het	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|CHROMOSOME|UBIQUITIN LIGASE COMPLEX	0.0513441012437734	0.00292731582047789	235	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity|cyclin binding	anaphase-promoting complex
YMR131C	RRB1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0510628133814188	0.00308691355444091	236	Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p	ribosome biogenesis	molecular_function	nucleolus
YML031W	NDC1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON|NUCLEAR PORE	0.0510552287640345	0.003091324697074	237	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1	nucleocytoplasmic transport|nuclear pore organization|spindle pole body duplication associated with nuclear envelope	structural constituent of nuclear pore	integral to membrane|nuclear pore transmembrane ring|spindle pole body|nuclear pore
YMR233W	TRI1	hom	FT	NUCLEUS	0.0510075992263192	0.00311915716098005	238	Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication	biological_process	molecular_function	nucleolus|nucleus|cytoplasm
YNL258C	DSL1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0509084883964198	0.00318233341041397	239	Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p; similar to the fly and human ZW10 gene	retrograde vesicle-mediated transport, Golgi to ER|ER-dependent peroxisome organization	molecular_function	Dsl1p complex|endoplasmic reticulum|peroxisome|nucleus
YBR020W	GAL1	hom	FT	CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	0.0508058591073099	0.00323959448068557	240	Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication	galactose catabolic process via UDP-galactose|carbohydrate phosphorylation|positive regulation of transcription by galactose	galactokinase activity	cytoplasm
YDL069C	CBS1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0507939833200632	0.00327455220592065	241	Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader	mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation	translation regulator activity	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial ribosome
YMR142C	RPL13B	hom	FT	TRANSLATION|RIBOSOME	0.0500763041256836	0.00371132136140112	242	Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOR033C	EXO1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.0499970547806012	0.00376615384820359	243	5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress	mismatch repair|telomeric 3' overhang formation|DNA double-strand break processing|meiotic DNA double-strand break processing|telomere maintenance|gene conversion at mating-type locus, DNA double-strand break processing	5'-3' exonuclease activity|5'-flap endonuclease activity	nucleus
YER159C	BUR6	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0499212168648807	0.00381931403970675	244	Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity|transcription corepressor activity	nucleus|negative cofactor 2 complex
YDR175C	RSM24	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0498935412041959	0.00386530327569754	245	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YGL116W	CDC20	het	FF|FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0497571767578319	0.00393663992961302	246	Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress	spindle checkpoint|activation of mitotic anaphase-promoting complex activity|meiotic anaphase I|positive regulation of protein catabolic process|activation of anaphase-promoting complex activity involved in meiotic cell cycle|positive regulation of mitotic metaphase/anaphase transition|cyclin catabolic process	anaphase-promoting complex binding|ubiquitin-protein ligase activator activity	mitotic checkpoint complex|anaphase-promoting complex
YDR394W	RPT3	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS	0.0495007543666307	0.00412660573663772	247	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	ATPase activity	proteasome regulatory particle, base subcomplex
YLR066W	SPC3	het	FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0494686285097004	0.00415098269577038	248	Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23	signal peptide processing|protein targeting to ER	peptidase activity	signal peptidase complex
YKL033W	TTI1	het	FT	CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0493280709325352	0.00426490478421379	249	Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	ASTRA complex|mitochondrion|cytoplasm
YIL083C	CAB2	het	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.0492350850537899	0.00433215654306245	250	Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)	coenzyme A biosynthetic process	phosphopantothenate--cysteine ligase activity	nucleus|cytoplasm
YDR188W	CCT6	het			0.0492231811346367	0.0043941796482173	251	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif	protein folding	unfolded protein binding	chaperonin-containing T-complex
YMR292W	GOT1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0491116724111459	0.00445443917236415	252	Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition	ER to Golgi vesicle-mediated transport|Golgi to endosome transport	molecular_function	integral to membrane|endoplasmic reticulum|Golgi apparatus|ER to Golgi transport vesicle|Golgi membrane
YDR450W	RPS18A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|MITOCHONDRION|RIBOSOME	0.0490201523378888	0.00450519361382829	253	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit|mitochondrion
YGR265W_d	YGR265W	het			0.0487776369311857	0.0047079339678874	254	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase	Unknown	Unknown	Unknown
YOR035C	SHE4	hom	FF|FT	CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	0.0486457959256503	0.00487873609387661	255	Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization	mating type switching|intracellular mRNA localization|actin cytoskeleton organization	myosin binding	cytoplasm
YJR082C	EAF6	hom	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.048547380728888	0.00490802882354817	256	Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3	DNA repair|histone acetylation	histone acetyltransferase activity	nucleus|NuA4 histone acetyltransferase complex|NuA3 histone acetyltransferase complex
YLR282C_d	YLR282C	hom			0.0485231636038476	0.00494882426194083	257	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition	Unknown	Unknown	Unknown
YFR052W	RPN12	het	FT	PROTEOLYSIS	0.0485129932511525	0.00493856299798202	258	Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress	ubiquitin-dependent protein catabolic process	molecular_function	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YLR005W	SSL1	het	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME	0.048466611682054	0.00499948509947414	259	Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p	phosphorylation of RNA polymerase II C-terminal domain|translational initiation|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YNL271C	BNI1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON	0.0483704755676341	0.00508009677646499	260	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1	barbed-end actin filament capping|actin nucleation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly|establishment of mitotic spindle orientation|formin-nucleated actin cable assembly	profilin binding	incipient cellular bud site|actin filament|polarisome|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YBR077C	SLM4	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|SIGNALING	0.0481313479910404	0.00535063403632946	261	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4	signal transduction|microautophagy	phosphatidylinositol-3,4-bisphosphate binding	fungal-type vacuole membrane|EGO complex|late endosome membrane|cytoplasm
YBR271W	EFM2	hom			0.0481088644919314	0.00531049581241484	262	S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis	peptidyl-lysine methylation	S-adenosylmethionine-dependent methyltransferase activity|protein-lysine N-methyltransferase activity	cytoplasm
YLR182W	SWI6	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS	0.0479248442524582	0.00551612308077153	263	Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of reciprocal meiotic recombination|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity	SBF transcription complex|MBF transcription complex|nucleus|cytoplasm
YDR041W	RSM10	het	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0478145631621783	0.00559706695580618	264	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YKR043C	SHB17	hom	FT	CARBOHYDRATE METABOLISM|NUCLEUS	0.0477098693967742	0.00570232663716426	265	Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus	ribose phosphate biosynthetic process	sedoheptulose-bisphosphatase activity	nucleus|cytoplasm
YIL021W	RPB3	het	FF|FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0476984382770957	0.0057428629638548	266	RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit	termination of RNA polymerase II transcription|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	nucleoplasm|DNA-directed RNA polymerase II, core complex
YNL275W	BOR1	hom	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT|PLASMA MEMBRANE	0.0475389444310109	0.00587801537890207	267	Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1	borate transport|protein targeting to vacuole	borate efflux transmembrane transporter activity	integral to membrane|plasma membrane|fungal-type vacuole
YFR031C	SMC2	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0471422146682866	0.00631253662769303	268	Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus	mitotic chromosome condensation|mitotic sister chromatid segregation|tRNA gene clustering	double-stranded DNA binding|ATPase activity|AT DNA binding|DNA secondary structure binding	mitochondrion|nuclear condensin complex
YBR039W	ATP3	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION	0.0470799257200704	0.00637421254614947	269	Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	ATP synthesis coupled proton transport	proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YDR069C	DOA4	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION	0.0469903604128545	0.00647531493172168	270	Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole	protein deubiquitination|endocytosis|regulation of DNA replication|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|free ubiquitin chain depolymerization|ubiquitin homeostasis|ubiquitin-dependent protein catabolic process	endopeptidase activity|ubiquitin-specific protease activity|ubiquitin thiolesterase activity	endosome|proteasome complex|mitochondrion
YMR086W	SEG1	hom			0.0469838426392921	0.00648272825295778	271	Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes	biological_process	molecular_function	eisosome|ribosome|cytoplasm
YJL008C	CCT8	het			0.0469256777384607	0.00654922374050774	272	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	protein folding	unfolded protein binding	chaperonin-containing T-complex|cytoplasm
YDR529C	QCR7	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0469112172448536	0.0065658501979289	273	Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration|mitochondrial respiratory chain complex III assembly	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YLR091W	GEP5	hom	FT	MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0468470156922059	0.00664012727864991	274	Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine	mitochondrial genome maintenance	molecular_function	mitochondrion
YOL046C_d	YOL046C	hom			0.0467232564764167	0.00678544295153713	275	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W	Unknown	Unknown	Unknown
YGL122C	NAB2	het	FT	RNA PROCESSING|RNA LOCALIZATION|NUCLEUS	0.0467053479369027	0.00680670575522625	276	Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress	poly(A)+ mRNA export from nucleus|mRNA polyadenylation|regulation of mRNA stability	poly(A) RNA binding	nucleus|cytoplasm
YIL148W	RPL40A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION|NUCLEUS|RIBOSOME	0.0466987431628328	0.0068228457895127	277	Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	cytoplasmic translation|protein ubiquitination|ribosome biogenesis	structural constituent of ribosome|protein tag	cytosolic large ribosomal subunit
YHL011C	PRS3	hom	FF|FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM	0.04656197752289	0.00697909839994663	278	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process|regulation of cell size	ribose phosphate diphosphokinase activity	cytoplasm
YBR098W	MMS4	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS	0.0464877630735886	0.00706986685113738	279	Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	transcription coactivator activity|endonuclease activity|crossover junction endodeoxyribonuclease activity	Holliday junction resolvase complex|nucleus
YKL183W	LOT5	hom	FT	NUCLEUS	0.0464256848872821	0.00715519826476904	280	Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YPL072W	UBP16	hom	FT	PROTEOLYSIS|MITOCHONDRION	0.0461927195027702	0.00744129107668568	281	Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria	protein deubiquitination	ubiquitin-specific protease activity	mitochondrial outer membrane|cytoplasm
YBR135W	CKS1	het	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|NUCLEUS	0.0459006357029004	0.00782612532603167	282	Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters	positive regulation of transcription, DNA-dependent|regulation of cell cycle|transcription, DNA-dependent|chromatin remodeling	ubiquitin binding|protein kinase activator activity|histone binding	cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YPL217C	BMS1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM|NUCLEUS|MITOCHONDRION	0.0458913228013843	0.00783868348876639	283	GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p	ribosome assembly|rRNA processing	U3 snoRNA binding|GTP binding|GTPase activity	mitochondrion|nucleolus|nucleus|90S preribosome|cytoplasm
YCL004W	PGS1	het	FT	LIPID METABOLISM|MITOCHONDRION	0.045764141995783	0.00801199786798276	284	Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis	cardiolipin biosynthetic process	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	mitochondrion
YMR179W	SPT21	hom	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING|NUCLEUS	0.0457636720898141	0.00801264453700462	285	Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress	chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	molecular_function	nucleus
YMR193W	MRPL24	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0457526890502405	0.00803717202272555	286	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YBL020W	RFT1	het	FT	MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.045609873798044	0.00822682330919762	287	Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein	glycolipid translocation	molecular_function|glycolipid-translocating activity	integral to membrane|endoplasmic reticulum membrane
YDR049W	VMS1	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0454516135054657	0.00845254770560202	288	Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans	ER-associated protein catabolic process|mitochondria-associated protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process	molecular_function	cytosol|mitochondrion|endoplasmic reticulum membrane|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytoplasm
YDR516C	EMI2	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0452866581435454	0.00876388398490785	289	Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YBR249C	ARO4	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0452706398391364	0.008717440032617	290	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress	aromatic amino acid family biosynthetic process	3-deoxy-7-phosphoheptulonate synthase activity	nucleus|cytoplasm
YMR311C	GLC8	hom	FT	SIGNALING|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION|NUCLEUS	0.0452606906954015	0.00873221539232877	291	Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress	chromosome segregation|glycogen biosynthetic process	enzyme activator activity	nucleus|cytoplasm
YLR320W	MMS22	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0452422805804908	0.00880997810480473	292	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation	replication fork processing|double-strand break repair|recombinational repair|meiotic sister chromatid segregation|response to DNA damage stimulus	molecular_function	Cul8-RING ubiquitin ligase complex|nucleus
YKL110C	KTI12	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.045152104153856	0.00892547368216388	293	Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p	regulation of transcription from RNA polymerase II promoter|cell growth|tRNA wobble uridine modification	chromatin binding	nucleus|cytoplasm
YAL034W-A	MTW1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.0447531268804974	0.00951631402693111	294	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly	chromosome segregation|protein localization to kinetochore	molecular_function	nuclear MIS12/MIND type complex|spindle pole
YPL246C	RBD2	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0443375806290134	0.0102043545788425	295	Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p	biological_process	molecular_function	COPI-coated vesicle|integral to membrane|Golgi apparatus
YGR219W_d	YGR219W	hom			0.0441757795452132	0.0104955254407001	296	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C	Unknown	Unknown	Unknown
YPR073C	LTP1	hom	FT	NUCLEUS	0.0440940381720827	0.0106278638984571	297	Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine	protein dephosphorylation	protein tyrosine phosphatase activity	nucleus|cytoplasm
YLR412C-A_p	YLR412C-A	hom			0.0439252640324376	0.0109304496075733	298	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR172W	SUP35	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEOTIDE METABOLISM	0.0439063105664467	0.0109649036801869	299	Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype	translational termination|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	translation release factor activity	cytosol|translation release factor complex
YPL084W	BRO1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.0438552003428182	0.0110582943500475	300	Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes	protein deubiquitination|vacuolar transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|response to nutrient|ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	endosome|cytoplasm
YPR025C	CCL1	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|NUCLEUS|MITOCHONDRION|RNA POL II, HOLOENZYME	0.0438468814238435	0.01107356167435	301	Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters	phosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity|cyclin-dependent protein kinase regulator activity	mitochondrion|holo TFIIH complex|TFIIK complex
YAL003W	EFB1	het	FT	TRANSLATION|RIBOSOME	0.0438409197154628	0.0110965237401551	302	Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site	translational elongation	translation elongation factor activity|guanyl-nucleotide exchange factor activity	ribosome|eukaryotic translation elongation factor 1 complex
YLR317W_d	YLR317W	het			0.043793365104589	0.0112206286106747	303	Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C	Unknown	Unknown	Unknown
YOR184W	SER1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0435883877495901	0.0116444110122635	304	3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress	serine family amino acid biosynthetic process|L-serine biosynthetic process|purine nucleobase biosynthetic process	O-phospho-L-serine:2-oxoglutarate aminotransferase activity	cytoplasm
YJL069C	UTP18	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0435821437128027	0.0115693011472506	305	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YLR089C	ALT1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0435643916839848	0.0116032366136174	306	Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive	alanine catabolic process|alanine biosynthetic process	L-alanine:2-oxoglutarate aminotransferase activity	mitochondrion
YIL004C	BET1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0434783111736607	0.0117690464973552	307	Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|endoplasmic reticulum membrane|ER to Golgi transport vesicle
YMR282C	AEP2	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0434153138886657	0.011891720829508	308	Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader	mitochondrial translational initiation	molecular_function	mitochondrion
YNL113W	RPC19	het	FT	NUCLEUS	0.0433300790067216	0.0120595018474117	309	RNA polymerase subunit AC19, common to RNA polymerases I and III	tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase III complex
YNL202W	SPS19	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0432504070571019	0.0122182254625073	310	Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate	fatty acid catabolic process|ascospore formation	2,4-dienoyl-CoA reductase (NADPH) activity	peroxisomal matrix
YNR033W	ABZ1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	0.0430775651038566	0.012621789180955	311	Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress	para-aminobenzoic acid biosynthetic process	4-amino-4-deoxychorismate synthase activity	cytoplasm
YLR027C	AAT2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0428465224817255	0.0130516489801435	312	Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells	aspartate biosynthetic process	L-aspartate:2-oxoglutarate aminotransferase activity	cytosol|peroxisome
YOR376W-A_p	YOR376W-A	hom			0.0427715252210402	0.0132118241125556	313	Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YBR061C	TRM7	hom	FT	RNA PROCESSING|TRANSLATION	0.0425820988744144	0.013638153241243	314	2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively	cytoplasmic translation|tRNA methylation	tRNA methyltransferase activity	cytoplasm
YNL056W	OCA2	hom			0.0425532896988833	0.013687845266525	315	Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene	biological_process	molecular_function	cytoplasm
YPR104C	FHL1	het	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|NUCLEUS|CHROMOSOME	0.0424815939870281	0.0139042774490077	316	Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter	RNA polymerase II transcription corepressor binding|RNA polymerase II transcription coactivator binding|sequence-specific DNA binding|DNA binding	nuclear chromatin|nucleolus|nucleus|CURI complex
YHR152W	SPO12	hom	FT	CELL CYCLE|NUCLEUS	0.0424416969616134	0.0139370559856746	317	Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis	regulation of exit from mitosis|mitotic cell cycle|meiosis I	molecular_function	nucleolus|nucleus
YBR008C	FLR1	hom	FT	PLASMA MEMBRANE	0.042381453166954	0.014073250626205	318	Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress	drug transmembrane transport|transmembrane transport	fluconazole transporter activity|drug transmembrane transporter activity	integral to membrane|plasma membrane
YPR021C	AGC1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.0419695858971811	0.0150362252619616	319	Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis	L-glutamate transport|aspartate transport|cellular nitrogen compound biosynthetic process	antiporter activity|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|uniporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YOR265W	RBL2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0418254935905639	0.0153865690051536	320	Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress	tubulin complex assembly|tubulin complex biogenesis	tubulin binding|beta-tubulin binding	cytoplasm
YGL249W	ZIP2	hom	FT	CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0415947106904059	0.0160098910277755	321	Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	synaptonemal complex assembly|synapsis|reciprocal meiotic recombination	molecular_function	synaptonemal complex
YJL128C	PBS2	hom	FF|FT	PROTEIN LOCALIZATION|SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH	0.0415262948510677	0.0161370504847045	322	MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition	activation of MAPK activity involved in osmosensory signaling pathway|actin filament organization|MAPK import into nucleus involved in osmosensory signaling pathway|protein phosphorylation|hyperosmotic response|osmosensory signaling pathway|cellular response to heat	MAP-kinase scaffold activity|MAP kinase kinase activity|protein kinase activity	cellular bud neck|cytoplasm|cellular bud tip
YPR175W	DPB2	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0415144470484913	0.0161674191779774	323	Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate	DNA-dependent DNA replication	double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity	nucleus|epsilon DNA polymerase complex|cytoplasm
YAL056W	GPB2	hom	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|MITOCHONDRION|PLASMA MEMBRANE	0.0414616193488308	0.0163034408103666	324	Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication	signal transduction|glucose mediated signaling pathway|pseudohyphal growth|ascospore formation|negative regulation of Ras protein signal transduction|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter	cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding	mitochondrion|plasma membrane|cytoplasm
YLR361C-A_p	YLR361C-A	hom			0.0414155785248651	0.0164228061355332	325	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKL092C	BUD2	hom	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM|PLASMA MEMBRANE	0.0414071014472402	0.016444867244089	326	GTPase activating factor for Rsr1p/Bud1p; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; mutant deficient in mitotic spindle position checkpoint	bipolar cellular bud site selection|small GTPase mediated signal transduction|filamentous growth|cellular bud site selection|axial cellular bud site selection	GTPase activator activity|Ras GTPase activator activity	intracellular
YLR403W	SFP1	hom	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|NUCLEUS	0.041375523609221	0.0165272759249915	327	Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion	positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of cell size|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription factor binding transcription factor activity	nucleus|cytoplasm
YBL004W	UTP20	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0413312788940928	0.0166433511368752	328	Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleoplasm|small-subunit processome|preribosome, small subunit precursor|nucleolus|90S preribosome|cytoplasm
YNL269W	BSC4	hom			0.0412771238153034	0.0167863994397535	329	Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p	biological_process	molecular_function	cellular_component
YDR478W	SNM1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0412516005851461	0.0168541912002429	330	Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP	mRNA cleavage|rRNA processing	ribonuclease MRP activity|RNA binding	ribonuclease MRP complex
YDR538W	PAD1	hom	FT	KETONE METABOLISM|MITOCHONDRION	0.0411706853060907	0.0170706991257409	331	Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX	cinnamic acid catabolic process|aromatic compound catabolic process	mRNA binding|carboxy-lyase activity	mitochondrion
YGR289C	MAL11	hom	FT	CARBOHYDRATE METABOLISM|PLASMA MEMBRANE	0.0411272499219786	0.0172543955140852	332	Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization	trehalose transport|maltose transport|disaccharide catabolic process	trehalose transmembrane transporter activity|alpha-glucoside:hydrogen symporter activity|maltose:hydrogen symporter activity	integral to membrane|plasma membrane
YDR347W	MRP1	hom	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0410526831862931	0.01739081331693	333	Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YCR067C	SED4	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0410419263541717	0.0174873731883073	334	Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p	positive regulation of GTPase activity|regulation of COPII vesicle coating	Sar GTPase activator activity	integral to endoplasmic reticulum membrane
YLL008W	DRS1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0408605212061066	0.0179233733497712	335	Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles	ribosomal large subunit assembly|rRNA processing	ATP-dependent RNA helicase activity	nucleolus|preribosome, large subunit precursor
YIL075C	RPN2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS	0.0406630554044888	0.0185204450048208	336	Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress	proteasome assembly|ubiquitin-dependent protein catabolic process	endopeptidase activity|protein binding, bridging	proteasome regulatory particle, base subcomplex|nucleus|proteasome storage granule
YNL098C	RAS2	hom	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS|PLASMA MEMBRANE	0.0406622320271235	0.0184878321309448	337	GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes	pseudohyphal growth|ascospore formation|activation of adenylate cyclase activity|regulation of protein localization|replicative cell aging|positive regulation of transcription by galactose|Ras protein signal transduction	GTP binding|GTPase activity	plasma membrane
YDL007W	RPT2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS	0.0406198579804909	0.0186104529813353	338	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle	positive regulation of protein catabolic process|proteasome regulatory particle assembly|peptide catabolic process|ubiquitin-dependent protein catabolic process	ATPase activity	proteasome regulatory particle, base subcomplex|nucleus
YJL202C_d	YJL202C	het			0.0406050353871724	0.0186535138034188	339	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex	Unknown	Unknown	Unknown
YLR356W	ATG33	hom	FT	MITOCHONDRION	0.0405863210000901	0.0188851438621435	340	Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes	mitochondrion degradation	molecular_function	mitochondrion|integral to membrane
YBR253W	SRB6	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0405631617889962	0.0187756310482448	341	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	positive regulation of transcription from RNA polymerase II promoter	molecular_function	core mediator complex
YIL107C	PFK26	hom	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.040374967626824	0.0193331374356242	342	6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YBR297W	MAL33	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|NUCLEUS	0.040266229736458	0.0196618096128148	343	MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C	cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent	sequence-specific DNA binding transcription factor activity	nucleus
YLR311C_d	YLR311C	hom			0.0402401199424795	0.0197414517962944	344	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL205C	HEM3	het	FT	COFACTOR METABOLISM|NUCLEUS	0.0400685328427148	0.0202718801153606	345	Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme	heme biosynthetic process	hydroxymethylbilane synthase activity	nucleus|cytoplasm
YBR029C	CDS1	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0399960212785137	0.0204997452379768	346	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids	phosphatidylserine metabolic process|phosphatidylglycerol biosynthetic process	phosphatidate cytidylyltransferase activity	mitochondrion|integral to membrane|endoplasmic reticulum
YER164W	CHD1	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME|HISTONE ACETYLTRANSFERASE	0.0399410774823428	0.0206738880318364	347	Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes	termination of RNA polymerase I transcription|ATP-dependent chromatin remodeling|nucleosome positioning|negative regulation of histone H3-K14 acetylation|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|regulation of transcriptional start site selection at RNA polymerase II promoter|nucleosome mobilization|Unknown|transcription elongation from RNA polymerase II promoter	chromatin DNA binding|DNA-dependent ATPase activity|methylated histone residue binding|DNA binding|rDNA binding	nuclear chromatin|SLIK (SAGA-like) complex|mitochondrion|SAGA complex|nucleolar chromatin
YGL070C	RPB9	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|NUCLEUS|RNA POL II, HOLOENZYME	0.0398792810324816	0.0210435342144449	348	RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription	transcription initiation from RNA polymerase II promoter|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|response to DNA damage stimulus|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity	DNA-directed RNA polymerase II, core complex
YJR037W_d	YJR037W	hom			0.0398466122873017	0.021129885763367	349	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces	Unknown	Unknown	Unknown
YPL121C	MEI5	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0397818174160714	0.0211859621873133	350	Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p	meiotic DNA recombinase assembly|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YGR075C	PRP38	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0397702253994096	0.0212429551448201	351	Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	molecular_function	U4/U6 x U5 tri-snRNP complex
YHL037C_d	YHL037C	hom			0.03961471651198	0.021735085749899	352	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR140W	CBF2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.0396082478944814	0.0217565894537822	353	Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; relative distribution to the spindle pole body decreases upon DNA replication stress	chromosome segregation|septin ring assembly|mitotic spindle elongation	DNA binding, bending|centromeric DNA binding	spindle midzone|condensed nuclear chromosome kinetochore|CBF3 complex|condensed nuclear chromosome, centromeric region|spindle
YOR177C	MPC54	hom	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|NUCLEUS|CYTOSKELETON	0.0395362645771725	0.0219971361325195	354	Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate	ascospore wall assembly|vesicle docking	structural molecule activity	spindle pole body
YMR291W	TDA1	hom	FT	PROTEIN PHOSPHORYLATION|NUCLEUS	0.039323404140938	0.0227220315049247	355	Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress	protein phosphorylation	protein kinase activity	nucleus|cytoplasm
YAL040C	CLN3	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.039305471478556	0.0228043194335238	356	G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis	vacuole organization|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|vacuole fusion, non-autophagic|regulation of cell size|G1/S transition of mitotic cell cycle	cyclin-dependent protein kinase regulator activity	nucleus
YNL134C	YNL134C	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEUS	0.0392917787721758	0.0228314829221348	357	Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress	biological_process	alcohol dehydrogenase (NADP+) activity	nucleus|cytoplasm
YMR049C	ERB1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.039287033480365	0.022847945219437	358	Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1	ribosomal large subunit biogenesis|rRNA processing	molecular_function	PeBoW complex|nucleolus|nucleus|preribosome, large subunit precursor
YLR148W	PEP3	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	0.0392607179893999	0.0230415043988685	359	Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|vacuole fusion, non-autophagic|late endosome to vacuole transport|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol binding|protein binding, bridging	fungal-type vacuole membrane|HOPS complex|proteasome storage granule|CORVET complex|extrinsic to vacuolar membrane
YOR304W	ISW2	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS	0.0392254056647839	0.0230626815394082	360	ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth	negative regulation of transcription from RNA polymerase II promoter by pheromones|nucleosome positioning|termination of RNA polymerase II transcription|negative regulation of antisense RNA transcription|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere	single-stranded DNA binding|DNA translocase activity	chromatin accessibility complex|nucleus
YFL048C	EMP47	hom	FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0391563358253053	0.0233054289352175	361	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport	ER to Golgi vesicle-mediated transport	glycoprotein binding	fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YNL296W_d	YNL296W	hom			0.0390741298383118	0.0235972306545089	362	Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog	Unknown	Unknown	Unknown
YCL017C	NFS1	het	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|COFACTOR METABOLISM|NUCLEUS|MITOCHONDRION	0.0389933235921304	0.0238871469699867	363	Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria	cellular iron ion homeostasis|iron-sulfur cluster assembly|mitochondrial tRNA thio-modification|tRNA thio-modification|tRNA wobble uridine modification	cysteine desulfurase activity	mitochondrion|nucleus
YOR174W	MED4	het	FF|FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0389513058962765	0.0240391145609631	364	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	transcription from RNA polymerase II promoter	molecular_function	core mediator complex
YHR065C	RRP3	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0388141989613676	0.0245408392642978	365	Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RNA-dependent ATPase activity|ATP-dependent RNA helicase activity	nucleolus
YML078W	CPR3	hom	FT	MITOCHONDRION	0.0387663792615043	0.0247179497467143	366	Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria	protein folding|apoptotic process	peptidyl-prolyl cis-trans isomerase activity	mitochondrion
YNR025C_d	YNR025C	hom			0.0387411622870652	0.024833315304503	367	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase	Unknown	Unknown	Unknown
YER017C	AFG3	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0387121288806499	0.0249202165985227	368	Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease; mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging	proteolysis|signal peptide processing|protein complex assembly|protein import into mitochondrial intermembrane space	metallopeptidase activity|protein binding|ATPase activity	mitochondrion|mitochondrial inner boundary membrane|mitochondrial inner membrane|m-AAA complex
YDR323C	PEP7	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	0.0385310623001351	0.0256057090274957	369	Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance	Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol-3-phosphate binding	external side of endosome membrane|cytoplasm
YFR041C	ERJ5	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0383312483279586	0.0264709875504616	370	Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response	protein folding	molecular_function	endoplasmic reticulum
YPR144C	NOC4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0382520148631345	0.0266940584249445	371	Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits	ribosomal small subunit biogenesis|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	molecular_function	small-subunit processome|nucleolus|nucleus|90S preribosome|Noc4p-Nop14p complex
YDR126W	SWF1	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|CYTOSKELETON	0.0382176519593617	0.0268308044777199	372	Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion	ascospore wall assembly|cortical actin cytoskeleton organization|establishment of cell polarity|vacuole fusion, non-autophagic|regulation of exocytosis|protein palmitoylation	palmitoyltransferase activity	integral to membrane|actin filament bundle|nuclear outer membrane-endoplasmic reticulum membrane network|actin cortical patch
YDL040C	NAT1	hom	FT	MITOCHONDRION|RIBOSOME	0.0381671822648389	0.0270327429179861	373	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	mitochondrion|NatA complex|cytosolic ribosome
YBR011C	IPP1	het			0.0381594782614412	0.0270865374864997	374	Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase	phosphate-containing compound metabolic process	inorganic diphosphatase activity|protein homodimerization activity	cytosol
YLR270W	DCS1	hom	FT	NUCLEUS|MITOCHONDRION	0.0381118726381534	0.0272555515538827	375	Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of nuclease activity|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|enzyme activator activity|m7G(5')pppN diphosphatase activity	mitochondrion|nucleus|cytoplasmic mRNA processing body|cytoplasm
YDL117W	CYK3	hom	FT	CELL CYCLE|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0381087027862651	0.0272683688001061	376	SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants	barrier septum assembly involved in cell cycle cytokinesis|cytokinesis	molecular_function	cellular bud neck contractile ring|cellular bud neck|cytoplasm
YCR086W	CSM1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|KINETOCHORE	0.0380584121583205	0.0275417468422023	377	Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation	meiotic chromosome segregation|rDNA condensation|protein localization to nucleolar rDNA repeats|homologous chromosome segregation	molecular_function	nuclear envelope|nucleolus|monopolin complex
YGR208W	SER2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0379788718375923	0.0278910555380399	378	Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source	L-serine biosynthetic process	phosphoserine phosphatase activity	nucleus|cytoplasm
YLR103C	CDC45	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0378490458975122	0.028336095296515	379	DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes	S phase of mitotic cell cycle|regulation of chromatin silencing at telomere|DNA replication initiation|pre-replicative complex assembly|double-strand break repair via break-induced replication	DNA replication origin binding|chromatin binding	replication fork protection complex|nucleus|DNA replication preinitiation complex|nuclear replication fork|pre-replicative complex
YDR075W	PPH3	hom	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.037744487113743	0.0287761089553341	380	Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes	Unknown|signal transduction involved in meiotic recombination checkpoint|double-strand break repair via homologous recombination|protein dephosphorylation|positive regulation of nitrogen compound metabolic process	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus|cytoplasm
YLR326W_p	YLR326W	hom			0.037731350073886	0.0288318071031622	381	Putative protein of unknown function, predicted to be palmitoylated	biological_process	molecular_function	cellular_component
YHR107C	CDC12	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.037729552201178	0.0290790549166558	382	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells	maintenance of cell polarity|cell cycle cytokinesis|positive regulation of protein kinase activity|septin ring assembly	protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding	septin filament array|cellular bud neck septin ring|septin complex|cytoplasm|mating projection
YCR065W	HCM1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|CHROMOSOME	0.0376980456544728	0.0289973708055295	383	Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role	positive regulation of transcription involved in S-phase of mitotic cell cycle|cellular response to oxidative stress|mitochondrion organization|spindle pole body organization|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	nuclear chromatin|nucleus|cytoplasm
YLR048W	RPS0B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME	0.0376417964247659	0.0292139723413423	384	Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YOL077W-A	ATP19	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.0376110895842103	0.0293460113784157	385	Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase	mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YKL094W	YJU3	hom	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0376056680969148	0.0293693769321485	386	Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family	triglyceride metabolic process	serine hydrolase activity|acylglycerol lipase activity	mitochondrial outer membrane|lipid particle|plasma membrane|membrane|cytoplasm
YLR406C	RPL31B	hom	FT	TRANSLATION|RIBOSOME	0.0374534838200289	0.0301054860310922	387	Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication	cytoplasmic translation|regulation of translational fidelity	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR065W	RRG1	hom	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.0373646026917076	0.0304246175147733	388	Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	mitochondrial genome maintenance|vacuolar acidification	molecular_function	mitochondrion
YLL056C_p	YLL056C	hom			0.0373403650509568	0.0305821362206042	389	Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin	biological_process	molecular_function	cellular_component
YDR207C	UME6	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|CHROMOSOME	0.0372836278660269	0.0308612172144314	390	Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p	spore germination|positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter during meiosis|lipid particle organization|nitrogen catabolite repression of transcription from RNA polymerase II promoter|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|repressing transcription factor binding|transcription factor binding transcription factor activity	Rpd3L-Expanded complex|Rpd3L complex
YNL285W_d	YNL285W	hom			0.037269245188669	0.0308509336584335	391	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL151W	NUT1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION	0.0372604475320834	0.0308905225136977	392	Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription	regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	molecular_function	mitochondrion|mediator complex|nucleus
YLR168C	UPS2	hom	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0370641708420446	0.0317851571026211	393	Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI	cristae formation|Unknown|phosphatidylethanolamine metabolic process|cardiolipin metabolic process	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YBL047C	EDE1	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0369158684849954	0.0324757676894743	394	Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death	endoplasmic reticulum unfolded protein response|endocytosis	ubiquitin binding	cellular bud neck|mating projection tip|actin cortical patch|cellular bud tip
YLR288C	MEC3	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0368035087814878	0.0330075195459949	395	DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1	telomere maintenance via recombination|DNA damage checkpoint|DNA metabolic process|chromatin silencing at telomere	DNA binding	nucleus|checkpoint clamp complex
YBR265W	TSC10	het	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.036779977164448	0.0331198235017274	396	3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family	3-keto-sphinganine metabolic process|sphingolipid biosynthetic process	oxidoreductase activity, acting on NADH or NADPH	mitochondrial outer membrane|endoplasmic reticulum|cytoplasm
YNL052W	COX5A	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0367730521216651	0.0331529352564125	397	Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YKR053C	YSR3	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0367730154074457	0.0331531108791029	398	Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication	phospholipid dephosphorylation|sphingolipid biosynthetic process	sphingosine-1-phosphate phosphatase activity	integral to membrane|endoplasmic reticulum
YNL162W-A_p	YNL162W-A	hom	FT	NUCLEUS	0.036771212441459	0.0332667648406512	399	Putative protein of unknown function; identified by homology	biological_process	molecular_function	nucleus|cytoplasm
YLR365W_d	YLR365W	hom			0.0365996225399798	0.0340181233859112	400	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene	Unknown	Unknown	Unknown
YIL063C	YRB2	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0365968823018254	0.0340048568028842	401	Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential	protein export from nucleus|regulation of chromatin silencing at telomere|ribosomal small subunit export from nucleus	molecular_function	integral to membrane|nucleus|nuclear pore
YPL238C_d	YPL238C	het	FF		0.0365886093970701	0.0341254474554908	402	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W	Unknown	Unknown	Unknown
YLR175W	CBF5	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION|NUCLEUS|CHROMOSOME|CYTOSKELETON	0.0364559784204648	0.0346996382453351	403	Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita	box H/ACA snoRNA 3'-end processing|rRNA pseudouridine synthesis|rRNA processing|snRNA pseudouridine synthesis	pseudouridine synthase activity	box H/ACA snoRNP complex|nucleolus|90S preribosome
YKL210W	UBA1	het	FT	NUCLEUS	0.0363479593237926	0.0353497944507259	404	Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress	protein ubiquitination	ubiquitin activating enzyme activity	nucleus|cytoplasm
YGL222C	EDC1	hom	FT	RNA PROCESSING|TRANSLATION|NUCLEUS	0.036276968477995	0.0355997636999115	405	RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of translation in response to stress	mRNA binding	nucleus|cytoplasm
YNL283C	WSC2	hom	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0362215376289201	0.0358824959005763	406	Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response	fungal-type cell wall organization|response to heat|Rho protein signal transduction	transmembrane signaling receptor activity	site of polarized growth|cellular bud|mating projection tip|cytoplasm
YHR040W	BCD1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0361188895589392	0.0364390206016593	407	Essential protein required for the accumulation of box C/D snoRNA	snoRNA metabolic process	nucleic acid binding	nucleus|cytoplasm
YML100W-A_p	YML100W-A	hom			0.0361107037486544	0.0364535612267806	408	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YDR386W	MUS81	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS	0.0360872728966016	0.0365752735939843	409	Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	crossover junction endodeoxyribonuclease activity|endonuclease activity	Holliday junction resolvase complex|nucleus
YLR400W_d	YLR400W	hom			0.0359406744105789	0.0373446671631628	410	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL087C	AIM19	hom	FT	MITOCHONDRION	0.0358598250385398	0.0377748501402276	411	Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth	biological_process	molecular_function	mitochondrion
YOR204W	DED1	het	FT	TRANSLATION	0.035858105841508	0.0377840431990875	412	ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility	translational initiation	RNA strand annealing activity|ATP-dependent RNA helicase activity	cytoplasm
YDR226W	ADK1	hom	FT	NUCLEOTIDE METABOLISM|MITOCHONDRION	0.0356375823693477	0.0389791262956175	413	Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress	ADP biosynthetic process|DNA replication initiation|nucleotide metabolic process	adenylate kinase activity	mitochondrion|mitochondrial intermembrane space|cytoplasm
YDR139C	RUB1	hom			0.0356090788336709	0.0391359129632911	414	Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)	protein neddylation	protein tag	cytoplasm
YML032C	RAD52	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0355589965390586	0.0394126925738624	415	Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis	postreplication repair|telomere maintenance via recombination|meiotic joint molecule formation|meiotic DNA recombinase assembly|DNA recombinase assembly|DNA strand renaturation|double-strand break repair via synthesis-dependent strand annealing|double-strand break repair via single-strand annealing|double-strand break repair via break-induced replication	recombinase activity	nuclear chromosome|nucleus
YJR018W_d	YJR018W	hom			0.0355550802367125	0.039434405854478	416	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR437W	GPI19	het	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0355497489936805	0.039463980349671	417	Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P	GPI anchor biosynthetic process	UDP-glycosyltransferase activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|nuclear envelope|integral to endoplasmic reticulum membrane|endoplasmic reticulum
YMR043W	MCM1	het	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|NUCLEUS|CHROMOSOME	0.0355203996235137	0.0396271300134789	418	Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes	regulation of mating type switching|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|DNA replication initiation|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of mating-type specific transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	DNA replication origin binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II repressing transcription factor binding	nuclear chromatin
YER073W	ALD5	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0354894112146405	0.0398000115643758	419	Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed	acetate biosynthetic process	aldehyde dehydrogenase [NAD(P)+] activity	mitochondrion
YDR510W	SMT3	het	FT	NUCLEUS|CHROMOSOME|CYTOSKELETON	0.0354548436788666	0.0399936151378093	420	Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2	protein sumoylation	protein tag	condensed nuclear chromosome|nucleus|septin ring
YAL007C	ERP2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0353922524976297	0.0403462040396201	421	Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles	ER to Golgi vesicle-mediated transport	molecular_function	ER to Golgi transport vesicle
YKL122C	SRP21	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEUS	0.0353918494463584	0.0403484830199768	422	Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER	signal sequence binding	nucleus|signal recognition particle, endoplasmic reticulum targeting
YBR084W	MIS1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.035346467174732	0.0406057875858244	423	Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase	nucleobase-containing compound metabolic process|folic acid biosynthetic process	formate-tetrahydrofolate ligase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methenyltetrahydrofolate cyclohydrolase activity	mitochondrion
YEL035C_p	UTR5	het			0.0353368346278151	0.0409010657977309	424	Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions	biological_process	molecular_function	cellular_component
YLR318W	EST2	hom	FT	NUCLEUS|CHROMOSOME	0.0353281630268356	0.04092046790483	425	Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia	telomere maintenance via telomerase|replicative cell aging	telomerase activity|telomeric template RNA reverse transcriptase activity|telomeric DNA binding	telomerase catalytic core complex|nucleolus|nucleus|telomerase holoenzyme complex
YIR021W-A_p	YIR021W-A	hom			0.0352869006404583	0.0409456217982661	426	Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YDR059C	UBC5	hom			0.0352824012976059	0.0410920360479535	427	Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication	protein polyubiquitination|response to stress	ubiquitin-protein ligase activity	proteasome complex
YOR347C	PYK2	hom	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0352740323901181	0.0410193522687143	428	Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication	pyruvate metabolic process	pyruvate kinase activity	cytosol|mitochondrion
YML069W	POB3	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0351147477966967	0.0419413440746159	429	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress	DNA replication-independent nucleosome organization|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|regulation of transcription by chromatin organization|DNA-dependent DNA replication	chromatin binding|nucleosome binding|histone binding	nuclear chromatin|FACT complex|replication fork protection complex|alpha DNA polymerase:primase complex
YOR200W_d	YOR200W	hom			0.0351115642224561	0.0419599489058265	430	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c	Unknown	Unknown	Unknown
YDL207W	GLE1	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|NUCLEAR PORE	0.0350834856273841	0.0421243429513194	431	Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export	poly(A)+ mRNA export from nucleus|mRNA export from nucleus|regulation of translational initiation|regulation of translational termination	translation initiation factor binding|inositol hexakisphosphate binding|phospholipid binding|enzyme activator activity	mitochondrion|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore|cytoplasm
YJR153W	PGU1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.0350369644906223	0.042397912906344	432	Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins	pseudohyphal growth|pectin catabolic process	polygalacturonase activity	extracellular region
YNR036C	MRPS12	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.034997043885535	0.042819655222079	433	Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins	mitochondrial translation	structural constituent of ribosome	mitochondrion|ribosome|mitochondrial small ribosomal subunit
YKL091C	YKL091C	hom	FT	NUCLEUS	0.0349842437259032	0.0427097543435922	434	Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study	biological_process	phosphatidylcholine binding|phosphatidylinositol transporter activity|phosphatidylinositol binding|phosphatidylcholine transporter activity	nucleus
YPL089C	RLM1	hom	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|NUCLEUS	0.0348829790712012	0.0433141703706725	435	MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication	signal transduction|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|DNA binding, bending|sequence-specific DNA binding	nucleus
YPL184C	MRN1	hom	FT	TRANSLATION	0.0346247279620741	0.0448883700671395	436	RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation	biological_process	molecular_function	cytoplasm
YIL112W	HOS4	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.0346087028239141	0.0449876222335888	437	Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate	negative regulation of meiosis|histone deacetylation	molecular_function	Set3 complex
YMR147W_p	YMR147W	hom			0.0345756871860819	0.0451926887564342	438	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR036W	PEP12	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0344954414713406	0.0457266949783656	439	Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin	Golgi to vacuole transport|vacuole inheritance	SNAP receptor activity	endosome|Golgi apparatus
YGL097W	SRM1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION|RNA LOCALIZATION|NUCLEUS|CHROMOSOME	0.0344705321163456	0.0459482615341826	440	Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p	ribosomal subunit export from nucleus|rRNA export from nucleus	signal transducer activity	nuclear chromatin|integral to membrane|nucleus
YMR229C	RRP5	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.034366150196979	0.0465452697119473	441	RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	poly(U) RNA binding	small-subunit processome|nucleolus|90S preribosome
YKL176C	LST4	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM	0.0343396984994244	0.0466815158833489	442	Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface	intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport	protein transporter activity	vesicle coat
YPR033C	HTS1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0343234552509523	0.0468510817541978	443	Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome	histidyl-tRNA aminoacylation|mitochondrial translation	aminoacyl-tRNA ligase activity	mitochondrion|cytoplasm
YBR163W	EXO5	hom	FT	MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0343096500385526	0.0468740168333248	444	Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2	mitochondrial genome maintenance	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity	mitochondrion
YGR214W	RPS0A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME	0.0341813526158467	0.0478363449485413	445	Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YCR009C	RVS161	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0340775168288294	0.0484507423802886	446	Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress	conjugation with cellular fusion|actin cytoskeleton reorganization|endocytosis|actin cortical patch localization|response to starvation|response to osmotic stress|lipid tube assembly|actin cytoskeleton organization	cytoskeletal protein binding|lipid binding	membrane raft|mating projection tip|mating projection|actin cortical patch
YHR011W	DIA4	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.03403190525029	0.0488534472462585	447	Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth	pseudohyphal growth|invasive growth in response to glucose limitation|mitochondrial seryl-tRNA aminoacylation	serine-tRNA ligase activity	mitochondrion|cytoplasm
YDL062W_d	YDL062W	hom			0.0339890338002065	0.0489698809059855	448	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential	Unknown	Unknown	Unknown
YJL047C	RTT101	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0338784582269143	0.0497447566214125	449	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p	replication fork processing|negative regulation of transposition, RNA-mediated|regulation of mitosis|nonfunctional rRNA decay|ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	Cul8-RING ubiquitin ligase complex|nucleus|cytoplasm
YEL007W	MIT1	hom	FT	NUCLEUS	0.0338289439489187	0.0500454742768099	450	Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1	biological_process	molecular_function	nucleus|cytoplasm
YLR058C	SHM2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|SITE OF POLARIZED GROWTH	0.0338085585332411	0.0502523696529108	451	Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis	one-carbon metabolic process	glycine hydroxymethyltransferase activity	plasma membrane|mating projection tip|cytoplasm
YNL305C	BXI1	hom	FT	SIGNALING|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.033722091357284	0.050774344196017	452	Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p	endoplasmic reticulum unfolded protein response|apoptotic process|calcium-mediated signaling	molecular_function	mitochondrion|integral to membrane|endoplasmic reticulum|fungal-type vacuole
YAR023C_p	YAR023C	hom			0.0336955791904897	0.0509565606311485	453	Putative integral membrane protein, member of DUP240 gene family	biological_process	molecular_function	cellular_component
YKL096W-A	CWP2	hom	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS	0.0336687699569903	0.0511413751049834	454	Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored	fungal-type cell wall organization|regulation of pH	structural constituent of cell wall	fungal-type cell wall
YLR272C	YCS4	het	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0336445045632377	0.0513091364967657	455	Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation	maintenance of rDNA|meiotic chromosome condensation|mitotic chromosome condensation|tRNA gene clustering|mitotic sister chromatid segregation|chromatin silencing at silent mating-type cassette	molecular_function	nucleolus|nuclear condensin complex
YGR280C	PXR1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0336228565395247	0.0514591908451897	456	Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain	box C/D snoRNA 3'-end processing|negative regulation of telomere maintenance via telomerase	telomerase inhibitor activity	nucleoplasm|nucleolus
YJL097W	PHS1	het	FT	KETONE METABOLISM|LIPID METABOLISM|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0335841330595699	0.0517285203043258	457	Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking	vacuolar transport|sphingolipid biosynthetic process	enoyl-CoA hydratase activity	fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum|fungal-type vacuole|nuclear outer membrane-endoplasmic reticulum membrane network
YPL063W	TIM50	het	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0335520995386371	0.0519522098975147	458	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel	protein import into mitochondrial matrix	mitochondrion targeting sequence binding|protein channel activity	mitochondrion|mitochondrial inner membrane presequence translocase complex
YKL042W	SPC42	het	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	0.0335421540540043	0.0521971597663436	459	Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane	microtubule nucleation|spindle pole body duplication associated with nuclear envelope	structural constituent of cytoskeleton	central plaque of spindle pole body|intermediate layer of spindle pole body
YLR299W	ECM38	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0335092474397128	0.052322960147357	460	Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation	xenobiotic metabolic process|glutathione catabolic process	gamma-glutamyltransferase activity	fungal-type vacuole
YDR201W	SPC19	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.0334429815482546	0.0527202578969606	461	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body	microtubule nucleation|mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization	microtubule binding|structural constituent of cytoskeleton	spindle microtubule|condensed nuclear chromosome kinetochore|DASH complex|spindle pole body|spindle
YCR106W	RDS1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0334268157142641	0.0528348470245548	462	Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide	response to xenobiotic stimulus	sequence-specific DNA binding|DNA binding	nucleus
YDR129C	SAC6	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0333879817184306	0.0537531933699519	463	Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress	bipolar cellular bud site selection|actin filament organization|endocytosis|response to osmotic stress	actin filament binding|protein binding, bridging	actin filament bundle|mating projection tip|actin cortical patch
YNL092W_p	YNL092W	hom			0.0332439328320071	0.0541457368400422	464	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YER146W	LSM5	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0331725500702445	0.054664711740775	465	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex
YOR082C_d	YOR082C	hom			0.0331397773112795	0.0549043652262055	466	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W	Unknown	Unknown	Unknown
YPL269W	KAR9	hom	FT	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0330982316162258	0.055318443318689	467	Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase	nuclear migration along microtubule|establishment of spindle localization	molecular_function	cell cortex|spindle pole body|mating projection tip
YNR068C_p	YNR068C	hom			0.0330859563890877	0.055299834664311	468	Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form	biological_process	molecular_function	cellular_component
YAL041W	CDC24	het	FT	CELL CYCLE|SIGNALING|NUCLEUS|SITE OF POLARIZED GROWTH	0.0330853002911336	0.0553046701924549	469	Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of exit from mitosis|establishment of cell polarity|small GTPase mediated signal transduction	Rho guanyl-nucleotide exchange factor activity	incipient cellular bud site|nucleus|cellular bud neck|mating projection tip|cellular bud tip|cytoplasm
YPL166W	ATG29	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	0.0330388280166976	0.0557210738962971	470	Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy	molecular_function	pre-autophagosomal structure|cytoplasm
YPL242C	IQG1	het	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0330007977268274	0.0559304160924985	471	Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress	actin filament organization|response to osmotic stress|cytokinesis	cytoskeletal protein binding	cellular bud neck contractile ring
YBR082C	UBC4	hom	FT	PROTEOLYSIS	0.0329692875451377	0.0561652543703065	472	Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress	ubiquitin binding|ubiquitin-protein ligase activity	proteasome complex
YLR306W	UBC12	hom			0.0329658484493685	0.0564115290798401	473	Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes	protein neddylation	NEDD8 ligase activity	cellular_component
YLR262C-A	TMA7	hom	FT	TRANSLATION|NUCLEUS	0.0329232091930173	0.0565469707904309	474	Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress	cytoplasmic translation	molecular_function	nucleus|cytoplasm
YNL147W	LSM7	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0329164144050939	0.0565611495764536	475	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasm
YOR020W-A_p	YOR020W-A	hom	FT	MITOCHONDRION	0.0327598863168794	0.0577468075147695	476	Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YDR099W	BMH2	hom	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.0327432153990857	0.0578742932566008	477	14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	glycogen metabolic process|ascospore formation|Ras protein signal transduction|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|DNA damage checkpoint|DNA replication initiation|signal transduction involved in filamentous growth|pseudohyphal growth|fungal-type cell wall chitin biosynthetic process|pre-replicative complex assembly	DNA replication origin binding|phosphoserine binding	nucleus|plasma membrane
YDL130W	RPP1B	hom	FT	TRANSLATION|RIBOSOME	0.0326993451013129	0.0584362224714035	478	Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component	cytoplasmic translation|translational elongation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR461W	PAU4	hom			0.0326992442873278	0.0582116709352768	479	Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YDR001C	NTH1	hom	FT	CARBOHYDRATE METABOLISM	0.0326820347735033	0.0583441585446295	480	Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication	trehalose catabolic process|response to stress	alpha,alpha-trehalase activity	cytosol|cytoplasm
YPR169W	JIP5	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0326058655487539	0.0589335580536534	481	Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein	ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus
YML061C	PIF1	hom	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|NUCLEUS|MITOCHONDRION	0.0325496546768934	0.0595616153912243	482	DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells	chromosome organization|negative regulation of telomere maintenance via telomerase|telomere maintenance|mitochondrial genome maintenance|DNA recombination	DNA helicase activity|telomerase inhibitor activity	mitochondrion|nucleus|mitochondrial membrane
YMR138W	CIN4	hom	FT	SIGNALING	0.03251192823611	0.05966724319705	483	GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog	protein folding|tubulin complex assembly|tubulin complex biogenesis	GTP binding	cytoplasm
YJR063W	RPA12	hom	FF|FT	NUCLEUS	0.032490261574402	0.0598375384150565	484	RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex	termination of RNA polymerase I transcription|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	molecular_function	DNA-directed RNA polymerase I complex
YPL167C	REV3	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.032478216427845	0.0599323847686147	485	Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair	error-prone translesion synthesis|error-free translesion synthesis	DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YOR297C	TIM18	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.0324752787784745	0.0599555354129126	486	Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex	cellular response to oxidative stress|protein import into mitochondrial inner membrane|apoptotic process|response to acid|response to osmotic stress|response to arsenic-containing substance	protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YKR006C	MRPL13	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0324534313401026	0.0601279405183507	487	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YLR141W	RRN5	het	FT	CHROMATIN ORGANIZATION|NUCLEUS	0.0323883049856557	0.0606443128093581	488	Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|chromatin organization	RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity	nucleolus|RNA polymerase I upstream activating factor complex
YIL147C	SLN1	het	FT	SIGNALING|PROTEIN PHOSPHORYLATION|PLASMA MEMBRANE	0.0323422623055283	0.0610501414991662	489	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators	negative regulation of protein kinase activity|protein autophosphorylation|peptidyl-histidine phosphorylation|osmosensory signaling pathway via two-component system	osmosensor activity|protein histidine kinase activity|histidine phosphotransfer kinase activity	plasma membrane|integral to plasma membrane
YML035C	AMD1	hom	FT	NUCLEOTIDE METABOLISM	0.0323118778804427	0.0616425907549861	490	AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools	guanine salvage|purine nucleotide metabolic process	AMP deaminase activity	cytoplasm
YIL070C	MAM33	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.032301094137544	0.0613415357098647	491	Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R	aerobic respiration	molecular_function	mitochondrion|mitochondrial matrix
YDL241W_p	YDL241W	hom			0.0322981880076395	0.061364883047363	492	Putative protein of unknown function; YDL241W is not an essential gene	biological_process	molecular_function	cellular_component
YLR312C_p	YLR312C	hom			0.0322826394724765	0.0614899222273561	493	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YER066C-A_d	YER066C-A	hom			0.0322496948907901	0.0617943866235277	494	Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W	Unknown	Unknown	Unknown
YAL044W-A_p	YAL044W-A	hom			0.0319829973101859	0.0639410763488555	495	Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein	biological_process	molecular_function	cellular_component
YLL021W	SPA2	hom	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH	0.0319113395705509	0.0645390556992259	496	Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate	regulation of initiation of mating projection growth|regulation of termination of mating projection growth|pseudohyphal growth|invasive filamentous growth|mating projection assembly	cytoskeletal regulatory protein binding	incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YMR257C	PET111	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0319063230056513	0.0645810908364974	497	Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrion|mitochondrial inner membrane
YMR020W	FMS1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	0.0319030735891475	0.0646083306155915	498	Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis	pantothenate biosynthetic process|polyamine catabolic process	polyamine oxidase activity	cytoplasm
YOR081C	TGL5	hom	FT	LIPID METABOLISM	0.0319019010127275	0.0647378767758687	499	Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate	triglyceride mobilization	lysophosphatidic acid acyltransferase activity|triglyceride lipase activity	lipid particle
YNR011C	PRP2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0318766252632936	0.0648303989785354	500	RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16	generation of catalytic spliceosome for first transesterification step	RNA-dependent ATPase activity	U2-type catalytic step 1 spliceosome
YJL033W	HCA4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0318376494216838	0.0652790958771241	501	DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis	rRNA processing	RNA-dependent ATPase activity|ATP-dependent RNA helicase activity	nucleolus
YDR112W_d	IRC2	hom			0.0318375818570358	0.066047076533262	502	Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci	Unknown	Unknown	Unknown
YIL138C	TPM2	hom	FT	VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0318108842125937	0.0653851092283303	503	Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication	vacuole inheritance|exocytosis|intracellular mRNA localization|budding cell apical bud growth|budding cell isotropic bud growth|mitochondrion inheritance|actin polymerization or depolymerization|vesicle-mediated transport|actin filament organization|establishment of cell polarity|actin filament bundle assembly	actin lateral binding	cellular bud neck contractile ring|actin filament bundle
YOR031W	CRS5	hom			0.0317047043209705	0.0662892921980583	504	Copper-binding metallothionein, required for wild-type copper resistance	response to metal ion	copper ion binding	cytoplasm
YJR134C	SGM1	hom	FT	GOLGI APPARATUS	0.0316504567256027	0.066755200857995	505	Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus	biological_process	molecular_function	COPI-coated vesicle|Golgi apparatus
YOR337W	TEA1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0316229591313871	0.0671146405377108	506	Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein	transcription, DNA-dependent	sequence-specific DNA binding|DNA binding	nucleus
YDL193W	NUS1	het	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0315700636613481	0.0678195199775069	507	Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY	protein glycosylation	prenyltransferase activity	nuclear envelope|lipid particle|endoplasmic reticulum
YOR052C	YOR052C	hom	FT	NUCLEUS	0.0315574197013425	0.0675605280558626	508	Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YOR266W	PNT1	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.031550489824961	0.0676208313321985	509	Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine	protein insertion into mitochondrial membrane from inner side	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YBL106C	SRO77	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|PLASMA MEMBRANE	0.0315170017989236	0.0679128657534332	510	Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication	exocytosis|Golgi to plasma membrane transport	molecular_function	plasma membrane
YML098W	TAF13	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0315146364103155	0.0679335324162992	511	TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors	RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	nucleus|transcription factor TFIID complex
YIL109C	SEC24	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0314808342606839	0.0683117661452852	512	Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p	cargo loading into COPII-coated vesicle	signal sequence binding	COPII vesicle coat
YGL082W_p	YGL082W	hom	FT	NUCLEUS	0.0314207424137384	0.0687994169155228	513	Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene	biological_process	molecular_function	nucleus|plasma membrane|cytoplasm
YML030W	RCF1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0313975294201707	0.0690045991502063	514	Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast	mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain supercomplex assembly	molecular_function	mitochondrion|mitochondrial respiratory chain supercomplex|integral to mitochondrial inner membrane|mitochondrial respiratory chain complex IV
YLR283W_p	YLR283W	hom	FT	MITOCHONDRION	0.0313339876572381	0.0697354954054724	515	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene	biological_process	molecular_function	mitochondrion
YHR075C	PPE1	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0312685427951323	0.0701120979943316	516	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein	cellular protein modification process|mitochondrial translation	structural constituent of ribosome|carboxylesterase activity	mitochondrial small ribosomal subunit
YGL094C	PAN2	hom	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	0.0312288507757055	0.0704687845567375	517	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes	mRNA 3'-end processing|postreplication repair|mRNA processing	poly(A)-specific ribonuclease activity	PAN complex|cytoplasm
YKL048C	ELM1	hom	FT	CELL CYCLE|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0310922998116853	0.0718767767531611	518	Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring	positive regulation of protein autophosphorylation|protein autophosphorylation|cell morphogenesis|budding cell bud growth|protein phosphorylation|response to drug|septin checkpoint|pseudohyphal growth|glucose metabolic process|axial cellular bud site selection|response to osmotic stress|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	cellular bud neck contractile ring
YEL002C	WBP1	het	FT	CELL CYCLE|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0310875490794429	0.0717930204498892	519	Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum	cell cycle|protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	nuclear envelope|oligosaccharyltransferase complex|endoplasmic reticulum
YLL058W_p	YLL058W	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0309902514040954	0.072644400561205	520	Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene	sulfur compound metabolic process	cystathionine gamma-synthase activity	cellular_component
YJL173C	RFA3	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0309661440062741	0.0728672427865488	521	Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress	establishment of protein localization|telomere maintenance via telomerase|telomere maintenance via recombination|nucleotide-excision repair|DNA repair|mitotic recombination|heteroduplex formation|DNA unwinding involved in replication|reciprocal meiotic recombination|double-strand break repair via homologous recombination|DNA replication|protein ubiquitination	double-stranded DNA binding|sequence-specific DNA binding	condensed nuclear chromosome|chromosome, telomeric region|DNA replication factor A complex
YMR048W	CSM3	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0308964679156455	0.0735144548264365	522	Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress	DNA repair|DNA replication checkpoint|meiotic chromosome segregation|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|mitotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	molecular_function	replication fork protection complex|nucleus
YBL027W	RPL19B	hom	FT	TRANSLATION|RIBOSOME	0.0308577992837724	0.0740049153417683	523	Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YHR210C_p	YHR210C	hom	FT	CARBOHYDRATE METABOLISM	0.0308544765355207	0.0739067715139511	524	Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions	biological_process	molecular_function	cellular_component
YDL082W	RPL13A	hom	FT	TRANSLATION|RIBOSOME	0.0307926836271415	0.0744871993118932	525	Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR158W	HOM2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS	0.0307541051518456	0.0753737302696897	526	Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	methionine biosynthetic process|threonine biosynthetic process|homoserine biosynthetic process	aspartate-semialdehyde dehydrogenase activity	nucleus|plasma membrane|cytoplasm
YMR021C	MAC1	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS|NUCLEUS	0.0307388466768275	0.0749959255860095	527	Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport	cellular copper ion homeostasis|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter	core promoter proximal region DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YIL096C_p	YIL096C	hom	FT	NUCLEUS	0.0307018351314581	0.07534730441417	528	Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleolus|nucleus
YNL041C	COG6	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0306628924379593	0.0758495089281699	529	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YML011C	RAD33	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0305567119449646	0.0767380515832321	530	Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	nucleotide-excision repair	molecular_function	nucleus
YKL118W_d	YKL118W	hom	FF		0.0305242926667193	0.0771838929753721	531	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2	Unknown	Unknown	Unknown
YER129W	SAK1	hom	FT	CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	0.030425392150815	0.0780588617236805	532	Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome	protein phosphorylation|glucose metabolic process|DNA-dependent DNA replication	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YOR272W	YTM1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0304251280270088	0.0780170632423255	533	Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats	chromosome organization|ribosomal large subunit biogenesis	molecular_function	PeBoW complex|nucleolus|nucleus|preribosome, large subunit precursor
YMR070W	MOT3	hom	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|NUCLEUS	0.0304218159567915	0.0780494794571309	534	Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion	cellular hyperosmotic response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ergosterol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	nucleus
YCL043C	PDI1	het	FT	ENDOPLASMIC RETICULUM	0.0304048528294129	0.0782156744943212	535	Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication	protein folding	protein disulfide oxidoreductase activity|protein disulfide isomerase activity	endoplasmic reticulum lumen
YCL036W	GFD2	hom			0.0303535078338722	0.0787204790257627	536	Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YJL167W	ERG20	het	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM	0.0302938593021184	0.0795793776012152	537	Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis	farnesyl diphosphate biosynthetic process|ergosterol biosynthetic process|isoprenoid biosynthetic process	dimethylallyltranstransferase activity|geranyltranstransferase activity	endoplasmic reticulum|cytoplasm
YMR197C	VTI1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.030292775837742	0.0793209901972016	538	Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways	Golgi to vacuole transport|vacuole fusion, non-autophagic|intra-Golgi vesicle-mediated transport|vesicle fusion	SNAP receptor activity	SNARE complex|integral to Golgi membrane
YOR386W	PHR1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION	0.0302841616526809	0.0794064670225065	539	DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p	photoreactive repair	mRNA binding|deoxyribodipyrimidine photo-lyase activity	mitochondrion|nucleus
YGR082W	TOM20	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION|MITOCHONDRION	0.0300931874435776	0.0813207688122718	540	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins	tRNA import into mitochondrion|protein import into mitochondrial matrix|mitochondrial outer membrane translocase complex assembly	protein channel activity|mitochondrion targeting sequence binding	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YAL001C	TFC3	het	FF|FT	PROTEIN LOCALIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0300562975515318	0.0816948283964475	541	Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding	protein localization to chromatin|transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter	RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending	transcription factor TFIIIC complex|mitochondrion|nuclear condensin complex
YJL048C	UBX6	hom	FT	PROTEOLYSIS|NUCLEUS	0.0300418938431765	0.0818412587024929	542	UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication	sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process	molecular_function	nucleus
YLR026C	SED5	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0299861814605479	0.0824553776205313	543	cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|cis-Golgi network
YGL169W	SUA5	het	FT	RNA PROCESSING|TRANSLATION|NUCLEUS|CHROMOSOME	0.0299517700834426	0.0829917806887053	544	Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family	threonylcarbamoyladenosine metabolic process|telomere maintenance|regulation of translational fidelity	single-stranded telomeric DNA binding	cytoplasm
YNL110C	NOP15	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS	0.0298312163441343	0.0841924643968907	545	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm	cytokinesis, actomyosin contractile ring assembly|ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YIL120W	QDR1	hom	FT	PLASMA MEMBRANE	0.0297971039261824	0.0843625289344892	546	Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication	drug transmembrane transport	drug transmembrane transporter activity	integral to membrane|plasma membrane
YGR291C_d	YGR291C	hom			0.0297805147255511	0.0845356416470615	547	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL219C	ALG9	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0297513267043376	0.0848409237135367	548	Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation	dolichol-linked oligosaccharide biosynthetic process|protein glycosylation	mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YKR023W_p	YKR023W	hom	FT	NUCLEUS|MITOCHONDRION	0.0296912902389424	0.0854716566020356	549	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YPL099C	AIM43	hom	FT	MITOCHONDRION	0.0296684899839476	0.0857588936203103	550	Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YJL002C	OST1	het	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.029653685745601	0.0858686490843006	551	Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins	protein N-linked glycosylation via asparagine|protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex
YIL059C_d	YIL059C	hom			0.0296307128478393	0.0861119070361536	552	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W	Unknown	Unknown	Unknown
YDR115W	YDR115W	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0295594721465952	0.0868698087631711	553	Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrial large ribosomal subunit
YIL028W_d	YIL028W	hom			0.0295209307625384	0.0872820736537332	554	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR092W	BUD4	hom	FT	CELL CYCLE|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0295154415307019	0.087340918394193	555	Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p	cellular bud site selection|axial cellular bud site selection	GTP binding	cellular bud neck contractile ring
YGL120C	PRP43	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION	0.0295142368390453	0.0873538370080677	556	RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|spliceosomal complex disassembly|ribosomal large subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA|rRNA processing	ATP-dependent RNA helicase activity	mitochondrion|post-mRNA release spliceosomal complex|90S preribosome
YNR034W	SOL1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0294497238636324	0.0880479015202749	557	Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	tRNA export from nucleus	molecular_function|6-phosphogluconolactonase activity	nucleus|cytoplasm
YER025W	GCD11	het	FT	TRANSLATION|NUCLEOTIDE METABOLISM|RIBOSOME	0.0294073855311346	0.0885058104391477	558	Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met	positive regulation of translational fidelity	GTP binding|tRNA binding|translation initiation factor activity	multi-eIF complex|ribosome|eukaryotic translation initiation factor 2 complex
YFR026C	ULI1	hom	FT	SIGNALING	0.0293878625417152	0.0887176060972358	559	Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response	endoplasmic reticulum unfolded protein response	molecular_function	cellular_component
YPL039W_p	YPL039W	hom			0.0293642720384426	0.0889740727806684	560	Putative protein of unknown function; YPL039W is not an essential gene	biological_process	molecular_function	cellular_component
YPL237W	SUI3	het	FT	TRANSLATION|RIBOSOME	0.0293486709998945	0.0891440088887033	561	Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding	translational initiation	translation initiation factor activity	multi-eIF complex|ribosome|eukaryotic translation initiation factor 2 complex
YBL024W	NCL1	hom	FT	RNA PROCESSING|NUCLEUS	0.0293482266017598	0.0891488533720076	562	S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120	tRNA methylation	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YKR002W	PAP1	het	FT	RNA PROCESSING|NUCLEUS	0.029272930262878	0.0899727411703783	563	Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping	mRNA polyadenylation|snoRNA polyadenylation	polynucleotide adenylyltransferase activity	nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex
YMR053C	STB2	hom	FT	NUCLEUS|CHROMOSOME	0.0292575698820723	0.0902855681773171	564	Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p	biological_process	molecular_function	Sin3-type complex
YIL093C	RSM25	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.029230976777714	0.0904344444063669	565	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YJL014W	CCT3	het	FF		0.0291814092364411	0.091175391489616	566	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	protein folding	unfolded protein binding	chaperonin-containing T-complex
YER062C	HOR2	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.0291715435839711	0.0910917734531825	567	Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication	cellular carbohydrate metabolic process|glycerol biosynthetic process|response to osmotic stress	glycerol-1-phosphatase activity	nucleus|cytoplasm
YOR316C-A_p	YOR316C-A	hom			0.0291529259664421	0.0912984716889055	568	Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YDR118W	APC4	het	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0290745059647858	0.0921732539529743	569	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YKL121W_p	DGR2	hom			0.0290674610624279	0.0922521688015803	570	Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds	biological_process	molecular_function	cellular_component
YCL035C	GRX1	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0290640676754242	0.0922901998396544	571	Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	protein glutathionylation|cellular response to oxidative stress	disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity	nucleus|cytoplasm
YBR215W	HPC2	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS	0.0290630221526659	0.0923019199652032	572	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes	DNA replication-independent nucleosome assembly|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	nucleosome binding|DNA binding	HIR complex|nucleus
YGR254W	ENO1	hom	FT	MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0290615942433599	0.0924637369494167	573	Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress	regulation of vacuole fusion, non-autophagic|gluconeogenesis|glycolysis	phosphopyruvate hydratase activity	mitochondrion|phosphopyruvate hydratase complex|plasma membrane|fungal-type vacuole|cytoplasm
YGR134W	CAF130	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0290215607283947	0.0927676592083133	574	Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation	regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter	molecular_function	CCR4-NOT core complex
YJR095W	SFC1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.0289808453770719	0.0934223077516283	575	Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization	succinate transport|fumarate transport	succinate:fumarate antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YIR022W	SEC11	het	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0289477886486092	0.0936010076635306	576	18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum	signal peptide processing|protein targeting to ER	peptidase activity	signal peptidase complex|endoplasmic reticulum
YGR162W	TIF4631	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION|RIBOSOME	0.0289463877974956	0.0936168899211094	577	Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication	translational initiation|ribosomal large subunit biogenesis|stress granule assembly	translation initiation factor activity	mitochondrion|ribosome|eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YNL226W_d	YNL226W	hom			0.0289305714037131	0.0937963594687588	578	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C	Unknown	Unknown	Unknown
YMR287C	DSS1	hom	FT	MITOCHONDRION	0.0288906045732271	0.0949905057477557	579	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs	mitochondrial RNA catabolic process	exoribonuclease II activity	mitochondrion|mitochondrial degradosome
YLR097C	HRT3	hom	FT	PROTEOLYSIS|UBIQUITIN LIGASE COMPLEX	0.0288683361705102	0.0945052257789284	580	Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YJR151W-A_p	YJR151W-A	hom			0.028866979011652	0.0947175827622213	581	Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YJR039W_p	YJR039W	hom	FT	MITOCHONDRION	0.02882133910726	0.0950433667109815	582	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGL100W	SEH1	hom	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE|NUCLEAR PORE	0.0287632299645133	0.0958606844780215	583	Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1	nucleocytoplasmic transport	structural constituent of nuclear pore	fungal-type vacuole membrane|integral to membrane|nuclear pore|Seh1-associated complex|nuclear pore outer ring
YMR244C-A	COA6	hom	FT	NUCLEUS|MITOCHONDRION	0.0287561469118062	0.097040059526033	584	Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YBR182C	SMP1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0287517380524669	0.095844839912623	585	Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress	DNA binding, bending|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YBR207W	FTH1	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	0.0287497889379647	0.0958673620456951	586	Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress	endocytosis|high-affinity iron ion transport	iron ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YMR174C	PAI3	hom			0.0287341122225439	0.0961974765670874	587	Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact	vacuolar protein catabolic process	endopeptidase inhibitor activity	cytoplasm
YDR327W_d	YDR327W	het			0.0287021886725604	0.0964187015554643	588	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1	Unknown	Unknown	Unknown
YDL011C_d	YDL011C	hom			0.0286105749030565	0.0979375650588119	589	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W	Unknown	Unknown	Unknown
YKR011C	YKR011C	hom	FT	NUCLEUS	0.028578192142142	0.0978668269677441	590	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YPL178W	CBC2	hom	FT	RNA PROCESSING|RNA LOCALIZATION|NUCLEUS	0.0285620380007808	0.098257335692551	591	Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif	mRNA splicing, via spliceosome	RNA cap binding	commitment complex|nuclear cap binding complex
YHR154W	RTT107	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0285412592979219	0.0983014980597831	592	Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress	negative regulation of transposition, RNA-mediated|double-strand break repair	molecular_function	Cul8-RING ubiquitin ligase complex|nucleus
YOL106W_d	YOL106W	hom			0.0284973659345702	0.0989710730509479	593	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR008C	STF2	hom	FT	MITOCHONDRION	0.0283704587262776	0.100483909238284	594	Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress	cellular response to desiccation	molecular_function	cytoplasm
YMR072W	ABF2	hom	FT	MITOCHONDRION ORGANIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0283512756077378	0.100561868024175	595	Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation	mitochondrion inheritance|mitochondrial DNA packaging|mitochondrial genome maintenance	DNA binding, bending|DNA binding	mitochondrial nucleoid|mitochondrial chromosome|mitochondrion
YLR352W_p	YLR352W	hom			0.0282914205762231	0.101486389358676	596	Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene	biological_process	molecular_function	SCF ubiquitin ligase complex
YPR181C	SEC23	het	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0282529126575178	0.101748324996295	597	GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p	regulation of COPII vesicle coating	GTPase activator activity	COPII vesicle coat
YFR020W_p	YFR020W	hom			0.0282041184375204	0.10239219167869	598	Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YLL045C	RPL8B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0281766872942876	0.102675397009308	599	Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR017C	KAP104	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|SITE OF POLARIZED GROWTH	0.0280707602050269	0.103974846255602	600	Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis	protein import into nucleus|cell cycle|mRNA-binding (hnRNP) protein import into nucleus|transcription factor import into nucleus	nuclear localization sequence binding	cytosol|integral to membrane|cellular bud neck|cellular bud tip
YER136W	GDI1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	0.0280403679265354	0.104350081715118	601	GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins	vesicle-mediated transport	Rab GDP-dissociation inhibitor activity	cellular_component
YML064C	TEM1	het	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON	0.0280364342780102	0.104398726622632	602	GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis	regulation of exit from mitosis	protein binding|GTPase activity	spindle pole body
YOL061W	PRS5	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM	0.0280185628473632	0.104619957862031	603	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YDR222W_p	YDR222W	hom	FT	RESPONSE TO OXIDATIVE STRESS	0.0280031725163379	0.104810773505491	604	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YIR023W	DAL81	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0279685703593281	0.105240793746003	605	Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism	nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process|urea catabolic process	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YGR165W	MRPS35	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0279478586614661	0.105863195879049	606	Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YGR057C	LST7	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM	0.0279380052800997	0.10562180601981	607	Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface	intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport	protein transporter activity	vesicle coat
YDR519W	FPR2	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0278720180490624	0.106448106534462	608	Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress	biological_process	FK506 binding|peptidyl-prolyl cis-trans isomerase activity	endoplasmic reticulum membrane
YLR117C	CLF1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|NUCLEUS|CHROMOSOME	0.0278423755219047	0.106820957461741	609	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins	cis assembly of pre-catalytic spliceosome|DNA replication initiation	DNA replication origin binding|chromatin binding|first spliceosomal transesterification activity|second spliceosomal transesterification activity	chromatin|U2-type post-mRNA release spliceosomal complex|Prp19 complex|U2-type prespliceosome|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YLR212C	TUB4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	0.0276857200501266	0.10923141613653	610	Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress	microtubule nucleation|mitotic spindle organization in nucleus	structural constituent of cytoskeleton	outer plaque of spindle pole body|gamma-tubulin small complex, spindle pole body|inner plaque of spindle pole body
YPL003W	ULA1	hom			0.0276739493482942	0.108959137905816	611	Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation	protein neddylation	NEDD8 activating enzyme activity	cellular_component
YDL110C	TMA17	hom	FT	NUCLEUS	0.0276144752196836	0.110093541878976	612	Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YPR003C_p	YPR003C	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0275165143052684	0.110988246896735	613	Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YML121W	GTR1	hom	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|GENE SILENCING|NUCLEUS	0.0273856487061334	0.112697509386636	614	Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB	phosphate ion transport|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|chromatin silencing at telomere	GDP binding|GTP binding	fungal-type vacuole membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YBR083W	TEC1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0273822224404294	0.112742537602704	615	Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member	pseudohyphal growth|chronological cell aging|positive regulation of transposition, RNA-mediated|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YNR056C	BIO5	hom	FT	KETONE METABOLISM|COFACTOR METABOLISM|PLASMA MEMBRANE	0.0273035490129706	0.113834263665501	616	Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis	biotin biosynthetic process|vitamin transport	transmembrane transporter activity	integral to membrane|plasma membrane
YGL028C	SCW11	hom	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	0.0272642373806767	0.114301770914476	617	Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p	cytokinesis, completion of separation	glucan endo-1,3-beta-D-glucosidase activity	fungal-type cell wall
YML070W	DAK1	hom	FT	CARBOHYDRATE METABOLISM	0.027235676397907	0.114681757969925	618	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation	response to stress|glycerol catabolic process	glycerone kinase activity	cytoplasm
YEL056W	HAT2	hom	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0272249873882404	0.114824224178992	619	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing	histone acetylation|chromatin assembly or disassembly|chromatin silencing at telomere	histone acetyltransferase activity|histone binding	histone acetyltransferase complex|nucleus|cytoplasm
YNL316C	PHA2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0271083892030789	0.116387332910301	620	Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway	L-phenylalanine biosynthetic process	prephenate dehydratase activity	cytoplasm
YJL127C-B_p	YJL127C-B	hom			0.0271051229795466	0.116758638054814	621	Putative protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i>	biological_process	molecular_function	cellular_component
YMR294W	JNM1	hom	FF|FT	CELL CYCLE|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0271035239135584	0.116452918099796	622	Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B	nuclear migration|establishment of mitotic spindle orientation	structural constituent of cytoskeleton	dynactin complex|cell cortex|spindle pole body|astral microtubule
YJL138C	TIF2	hom	FT	TRANSLATION|RIBOSOME	0.0270630436978907	0.116999726264474	623	Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication	translational initiation|regulation of translational initiation	ATP-dependent RNA helicase activity|translation initiation factor activity	ribosome|eukaryotic translation initiation factor 4F complex|plasma membrane|cytoplasm
YGR260W	TNA1	hom	FT	MITOCHONDRION|PLASMA MEMBRANE	0.0269936892489621	0.117941250212217	624	High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)	nicotinamide mononucleotide transport	nicotinamide mononucleotide transmembrane transporter activity	mitochondrion|integral to membrane|integral to plasma membrane
YIL162W	SUC2	hom	FT	CARBOHYDRATE METABOLISM|MITOCHONDRION	0.0269146122930387	0.119022000521968	625	Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively	sucrose catabolic process	beta-fructofuranosidase activity	mitochondrion|extracellular region|cytoplasm
YPL070W	MUK1	hom			0.0268818459415511	0.119472087723289	626	Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation	biological_process	molecular_function	cytoplasm
YIL035C	CKA1	hom	FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0268606291167089	0.119764237840274	627	Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching	regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase activity|protein kinase activity	protein kinase CK2 complex|UTP-C complex
YDL092W	SRP14	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEUS	0.0268479487104618	0.119939110566419	628	Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER	signal sequence binding	signal recognition particle, endoplasmic reticulum targeting
YML094W	GIM5	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS	0.0268087883867776	0.120480424064274	629	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it	tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YGR049W	SCM4	hom	FT	MITOCHONDRION	0.0267853519507969	0.120805299300545	630	Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to membrane
YDR417C_d	YDR417C	hom			0.0267480085254012	0.121324368132668	631	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W	Unknown	Unknown	Unknown
YJR017C	ESS1	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING|NUCLEUS	0.0266959856548808	0.122050384022682	632	Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3	termination of RNA polymerase II transcription|positive regulation of protein dephosphorylation|negative regulation of histone deacetylation|negative regulation of transcription from RNA polymerase II promoter|protein peptidyl-prolyl isomerization|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle	peptidyl-prolyl cis-trans isomerase activity|RNA polymerase II core binding	nucleus
YJR070C	LIA1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION|NUCLEUS	0.026694019716595	0.122245003879776	633	Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress	microtubule cytoskeleton organization|peptidyl-lysine modification to hypusine	deoxyhypusine monooxygenase activity	nucleus|cytoplasm
YDR151C	CTH1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|NUCLEUS	0.0266915588659768	0.122112319368667	634	Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis	nuclear-transcribed mRNA catabolic process|cellular iron ion homeostasis	mRNA binding	nucleus
YOL164W	BDS1	hom			0.0266458118203959	0.123033175034413	635	Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources	dodecyl sulfate metabolic process	arylsulfatase activity|alkyl sulfatase activity	cellular_component
YJL063C	MRPL8	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0265965049683094	0.123448154630715	636	Mitochondrial ribosomal protein of the large subunit	mitochondrial genome maintenance|mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOL011W	PLB3	hom	FT	LIPID METABOLISM|PLASMA MEMBRANE	0.0265585760812865	0.124040428059638	637	Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro	phosphatidylinositol metabolic process|phosphatidylserine catabolic process	lysophospholipase activity	extracellular region|plasma membrane
YOR123C	LEO1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|RNA POL II, HOLOENZYME	0.0265555496526577	0.124195540582636	638	Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	chromatin organization|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription-coupled nucleotide-excision repair|histone H3-K4 trimethylation|transcription elongation from RNA polymerase II promoter	RNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|Cdc73/Paf1 complex
YNR055C	HOL1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION|PLASMA MEMBRANE	0.0265530865607275	0.124118199988607	639	Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake	organic alcohol transport|cation transport	alcohol transmembrane transporter activity|inorganic cation transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YMR031W-A_d	YMR031W-A	hom			0.0264809961489512	0.125368515213874	640	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C	Unknown	Unknown	Unknown
YLR070C	XYL2	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM	0.0264691815554777	0.125255322794606	641	Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect	xylulose biosynthetic process	D-xylulose reductase activity	cellular_component
YDR147W	EKI1	hom	FT	LIPID METABOLISM	0.0264028214762248	0.126205342362879	642	Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolamine kinase activity|choline kinase activity	cytoplasm
YLR105C	SEN2	het	FT	RNA PROCESSING|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	0.0263946776829861	0.126718690957832	643	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease	tRNA-type intron splice site recognition and cleavage	tRNA-intron endonuclease activity	mitochondrial outer membrane|mitochondrion|tRNA-intron endonuclease complex
YNL161W	CBK1	het	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH	0.0263057155821576	0.127662415752973	644	Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress	regulation of fungal-type cell wall organization|establishment or maintenance of cell polarity|protein phosphorylation|establishment or maintenance of actin cytoskeleton polarity|budding cell apical bud growth|Unknown	protein serine/threonine kinase activity	incipient cellular bud site|cellular bud|cellular bud neck|cellular bud tip|cytoplasm|cell cortex|nucleus|mating projection tip
YHR051W	COX6	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0263002232955151	0.127685179753216	645	Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YDL148C	NOP14	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION	0.026297394016361	0.127726178524119	646	Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit biogenesis|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	snoRNA binding	small-subunit processome|mitochondrion|nucleolus|90S preribosome|Noc4p-Nop14p complex
YGL211W	NCS6	hom	FT	RNA PROCESSING|MITOCHONDRION	0.0262635762938467	0.12821701997758	647	Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	tRNA wobble position uridine thiolation|protein urmylation|tRNA wobble uridine modification	tRNA binding	cytosol|mitochondrion
YPL277C_p	YPL277C	hom			0.0262089258124372	0.12929896531219	648	Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels	biological_process	molecular_function	membrane
YMR259C	TRM732	hom			0.0262047225625595	0.129074735820168	649	Interacts with Trm7p for 2'-O-methylation of C32 of substrate tRNAs; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene	biological_process	molecular_function	cytoplasm
YLL043W	FPS1	hom	FT	ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0261815399633626	0.12941381231106	650	Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress	conjugation with cellular fusion|transport|arsenite transport|glycerol transport|acetate transport|response to arsenic-containing substance	glycerol transmembrane transporter activity|transporter activity	integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YHL026C_p	YHL026C	hom			0.0261765644325891	0.129543838445954	651	Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)	biological_process	molecular_function	cellular_component
YKL008C	LAC1	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0261736135372728	0.129529905373223	652	Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p	replicative cell aging|ceramide biosynthetic process	sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YBR115C	LYS2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0261535251316802	0.129824488838695	653	Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p	lysine biosynthetic process via aminoadipic acid	L-aminoadipate-semialdehyde dehydrogenase activity	cytoplasm
YEL071W	DLD3	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS	0.0261414760456372	0.130001430148246	654	D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm	lactate metabolic process|filamentous growth	D-lactate dehydrogenase (cytochrome) activity	cytoplasm
YML123C	PHO84	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0261075478006144	0.130558030734308	655	High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity	phosphate ion transport|manganese ion transport|polyphosphate metabolic process	manganese ion transmembrane transporter activity|inorganic phosphate transmembrane transporter activity	integral to membrane|integral to plasma membrane
YIL090W	ICE2	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0260714618973147	0.131033295418028	656	Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells	endoplasmic reticulum inheritance	molecular_function	integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum
YLR433C	CNA1	hom	FT	SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS	0.0260457595620548	0.132511616836597	657	Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity	calcineurin complex|cytoplasm
YPL177C	CUP9	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0260215281654444	0.131773086750542	658	Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YDR404C	RPB7	het	FF|FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|TRANSLATION|NUCLEUS|RNA POL II, HOLOENZYME	0.0260203212405592	0.131906243482638	659	RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation	transcription initiation from RNA polymerase II promoter|positive regulation of translational initiation|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|nuclear-transcribed mRNA catabolic process, exonucleolytic|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|translation initiation factor binding|single-stranded RNA binding|single-stranded DNA binding	nucleus|DNA-directed RNA polymerase II, core complex|cytoplasmic mRNA processing body|cytoplasm
YDR137W	RGP1	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL DIVISION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0259838602994678	0.13296960869805	660	Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p	retrograde transport, endosome to Golgi	guanyl-nucleotide exchange factor activity	Golgi apparatus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YPL183C	RTT10	hom	FT	VESICLE-MEDIATED TRANSPORT	0.0259713344649454	0.132693294956731	661	WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6	endocytic recycling	molecular_function	endosome|cytoplasm
YCL010C	SGF29	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0259624743850425	0.132652166928484	662	Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation	histone H3-K14 acetylation|cellular protein complex localization|histone H3-K18 acetylation|cellular protein localization|histone H3-K9 acetylation|positive regulation of transcription from RNA polymerase II promoter	methylated histone residue binding|RNA polymerase II transcription factor recruiting transcription factor activity	Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YPL254W	HFI1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0259424755033108	0.132950898914435	663	Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions	histone acetylation|chromatin modification|transcription from RNA polymerase II promoter	transcription coactivator activity|transcription cofactor activity	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YKL003C	MRP17	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.025924210560962	0.133224184891098	664	Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YJR118C	ILM1	hom	FF|FT	MITOCHONDRION ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0259203975513241	0.133281291169932	665	Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth	mitochondrial genome maintenance	molecular_function	integral to membrane|endoplasmic reticulum
YGL017W	ATE1	hom	FT	PROTEOLYSIS	0.0258854965595872	0.133804872921408	666	Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway	cellular protein modification process|protein arginylation	arginyltransferase activity	cytoplasm
YER171W	RAD3	het	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME	0.0258774202946862	0.133926258672373	667	5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress	regulation of transposition, RNA-mediated|phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair, DNA incision|regulation of mitotic recombination|transcription from RNA polymerase II promoter	damaged DNA binding|ATP-dependent 5'-3' DNA helicase activity|core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YNR072W	HXT17	hom	FT	PLASMA MEMBRANE	0.0258652990740332	0.134457251321985	668	Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose	hexose transport	mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YDL147W	RPN5	het	FT	PROTEOLYSIS|NUCLEUS	0.0258392857712619	0.134500568594759	669	Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein	cullin deneddylation|ubiquitin-dependent protein catabolic process	molecular_function	proteasome complex|signalosome|proteasome storage granule|proteasome regulatory particle, lid subcomplex
YGR123C	PPT1	hom	FT	NUCLEUS	0.0258287807343836	0.134659109428429	670	Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth	protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YGR182C_d	YGR182C	hom			0.0258165666053812	0.135076490710788	671	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W	Unknown	Unknown	Unknown
YHR006W	STP2	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|PLASMA MEMBRANE	0.0257335277404678	0.136103254502917	672	Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YBR150C	TBS1	hom	FT	TRANSCRIPTION FROM RNA POL II|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	0.0257162330576492	0.136717877826651	673	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication	biological_process	sequence-specific DNA binding	mitochondrion|nucleus|cytoplasm
YMR113W	FOL3	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	0.0257032492539766	0.136564805931892	674	Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis	folic acid-containing compound biosynthetic process	dihydrofolate synthase activity	cytoplasm
YMR308C	PSE1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|RNA LOCALIZATION|NUCLEUS	0.0256628978686981	0.137181779534954	675	Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p	mRNA export from nucleus|regulation of protein desumoylation|protein import into nucleus|regulation of mitosis	protein transporter activity|nuclear localization sequence binding	integral to membrane|nucleus|cytoplasm
YMR190C	SGS1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0256204436042386	0.137833223730531	676	Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes; forms nuclear foci upon DNA replication stress	DNA double-strand break processing|meiotic DNA double-strand break processing|telomeric 3' overhang formation|meiotic chromosome segregation|DNA unwinding involved in replication|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint|telomere maintenance via recombination|replicative cell aging|DNA duplex unwinding|response to DNA damage stimulus|negative regulation of meiotic joint molecule formation|chromosome organization|regulation of reciprocal meiotic recombination|gene conversion at mating-type locus, DNA double-strand break processing|mitotic sister chromatid segregation	ATP-dependent DNA helicase activity	RecQ helicase-Topo III complex|nucleolus
YDR194C	MSS116	hom	FT	RNA PROCESSING|TRANSLATION|MITOCHONDRION	0.0255585953035656	0.138845411824113	677	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing	RNA folding|Group I intron splicing|Group II intron splicing	RNA binding|RNA strand annealing activity|ATP-dependent RNA helicase activity	mitochondrion|mitochondrial matrix
YML058W	SML1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|NUCLEUS	0.0255494382849889	0.138928096542561	678	Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase	mitochondrion organization|response to DNA damage stimulus	enzyme inhibitor activity	nucleus|cytoplasm
YER104W	RTT105	het	FT	NUCLEUS	0.0255346384185043	0.139157145259695	679	Protein with a role in regulation of Ty1 transposition	negative regulation of transposition, RNA-mediated	molecular_function	nucleus|cytoplasm
YBR191W	RPL21A	hom	FT	TRANSLATION|RIBOSOME	0.0255318608647748	0.139200164176113	680	Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR099C_d	YBR099C	hom			0.0255152896385413	0.139457033018634	681	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4	Unknown	Unknown	Unknown
YMR173W	DDR48	hom	FT	RESPONSE TO DNA DAMAGE	0.0255023817076012	0.139657370067134	682	DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress	DNA repair	ATPase activity|GTPase activity	cytoplasm
YDR079C-A	TFB5	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME	0.025492597414841	0.139809374266362	683	Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleus
YJL043W_p	YJL043W	hom	FT	MITOCHONDRION	0.0254886887536466	0.139870132959997	684	Putative protein of unknown function; YJL043W is a non-essential gene	biological_process	molecular_function	mitochondrion|cytoplasm
YPR154W	PIN3	hom	FT	CYTOSKELETON ORGANIZATION|NUCLEUS	0.0254640107345318	0.140254212642688	685	Protein that induces appearance of [PIN+] prion when overproduced	actin cytoskeleton organization	molecular_function	nucleus|cytoplasm
YKL193C	SDS22	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS	0.0254381690611489	0.140775733685584	686	Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function	maintenance of protein location in nucleus|chromosome segregation	protein serine/threonine phosphatase inhibitor activity|protein phosphatase type 1 activator activity	protein phosphatase type 1 complex|nucleus|cytoplasm
YML091C	RPM2	het	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION|NUCLEUS|MITOCHONDRION	0.025401597674759	0.141229205419921	687	Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus	cytoplasmic translation|tRNA 5'-leader removal|mRNA processing|mitochondrion organization|RNA processing|positive regulation of transcription from RNA polymerase II promoter	ribonuclease P activity	mitochondrion|nucleus|mitochondrial matrix|cytoplasmic mRNA processing body|mitochondrial ribonuclease P complex
YML072C	TCB3	hom	FT	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE	0.0253057137932265	0.142737199424669	688	Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact	biological_process	lipid binding	mitochondrion|cortical endoplasmic reticulum|cellular bud
YDL230W	PTP1	hom	FT	MITOCHONDRION	0.0252821552147656	0.1431095958764	689	Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation	pseudohyphal growth|invasive growth in response to glucose limitation|protein dephosphorylation	protein tyrosine phosphatase activity	mitochondrion|cytoplasm
YGR215W	RSM27	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0252095832884718	0.144261442688356	690	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YOR372C	NDD1	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS	0.0252006616300211	0.144883194509878	691	Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes	positive regulation of transcription involved in G2/M-phase of mitotic cell cycle	transcription coactivator activity	nucleus
YDR490C	PKH1	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	0.0251933341477796	0.14476000116335	692	Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p	regulation of nuclear-transcribed mRNA poly(A) tail shortening|endocytosis|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly	protein kinase activity	cytosol|cell cortex|eisosome
YBR292C_d	YBR292C	hom			0.0251909311894583	0.144558629355924	693	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene	Unknown	Unknown	Unknown
YML042W	CAT2	hom	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0251852751859325	0.144648839901981	694	Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes	carnitine metabolic process	carnitine O-acetyltransferase activity	mitochondrion|peroxisomal matrix|peroxisome
YPR119W	CLB2	hom	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0251362958792663	0.14543184069518	695	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|spindle pole body|cellular bud neck|spindle|cytoplasm
YDR292C	SRP101	het	FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0251173788825143	0.145735121565142	696	Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p	SRP-dependent cotranslational protein targeting to membrane|protein targeting to ER	GTP binding|signal recognition particle binding	endoplasmic reticulum membrane|signal recognition particle receptor complex
YJL029C	VPS53	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0250967454165168	0.146066472758923	697	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting	Golgi to vacuole transport|retrograde transport, endosome to Golgi	molecular_function	Golgi apparatus|GARP complex|cytoplasm
YER172C	BRR2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0250726067861726	0.146454844249799	698	RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	ATP-dependent RNA helicase activity	U4/U6 x U5 tri-snRNP complex|U5 snRNP
YKL134C	OCT1	hom	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.0250471738872846	0.146864893303748	699	Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis	cellular iron ion homeostasis|protein processing involved in protein targeting to mitochondrion	metalloendopeptidase activity	mitochondrion
YLR410W	VIP1	hom	FT	CYTOSKELETON	0.0250132522042746	0.147413170359136	700	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1	inositol phosphate biosynthetic process	inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 4-kinase activity|inositol hexakisphosphate 6-kinase activity	cytoplasm
YHR077C	NMD2	hom			0.0249456843715586	0.148509929357971	701	Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|translational frameshifting	molecular_function	polysome|cytoplasm
YJL143W	TIM17	het	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0248815688036094	0.149556400553624	702	Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex	protein import into mitochondrial matrix|mitochondrial genome maintenance	protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane presequence translocase complex
YFR042W	KEG1	het	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0248504662587084	0.150066066498419	703	Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability	chromosome organization|(1->6)-beta-D-glucan biosynthetic process	molecular_function	integral to endoplasmic reticulum membrane|integral to membrane
YLR260W	LCB5	hom	FT	LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0248495570657282	0.15087344822208	704	Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules	response to heat|calcium-mediated signaling|sphingolipid metabolic process	D-erythro-sphingosine kinase activity	Golgi apparatus|membrane
YOR085W	OST3	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0247659444053858	0.151457782724438	705	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins	protein glycosylation|protein complex assembly|protein O-linked mannosylation|protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex|integral to membrane
YJL038C	LOH1	hom			0.0246325365628803	0.153735765741978	706	Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1	chromosome organization	molecular_function	cellular_component
YLR408C_p	BLS1	hom			0.0245964528480365	0.15433961998795	707	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene	biological_process	molecular_function	endosome|BLOC-1 complex
YGL089C	MF(ALPHA)2	hom	FT	SIGNALING	0.0245882095167705	0.15441635332226	708	Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YLL061W	MMP1	hom	FT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.0245789790848127	0.154571193338819	709	High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p	S-methylmethionine transport	S-methylmethionine transmembrane transporter activity	integral to membrane|plasma membrane
YOL031C	SIL1	hom	FT	PROTEIN LOCALIZATION|ENDOPLASMIC RETICULUM	0.0245537883789522	0.155117509909496	710	Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein	SRP-dependent cotranslational protein targeting to membrane, translocation	adenyl-nucleotide exchange factor activity	endoplasmic reticulum
YEL028W_d	YEL028W	hom			0.0244702494499437	0.156465782801138	711	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR173W_p	YLR173W	hom			0.0244591378987439	0.156592238924646	712	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YML126C	ERG13	het	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM	0.0244307702846572	0.157073559730749	713	3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis	ergosterol biosynthetic process	hydroxymethylglutaryl-CoA synthase activity	endoplasmic reticulum
YKL171W	NNK1	hom	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION	0.0244286480687024	0.157109612946721	714	Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm	proteolysis|protein phosphorylation	protein kinase activity	cytoplasm
YCL032W	STE50	hom	FT	CELL CYCLE|SIGNALING	0.0244285702574647	0.157420599283603	715	Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction	pheromone-dependent signal transduction involved in conjugation with cellular fusion|MAPK cascade involved in osmosensory signaling pathway|osmosensory signaling pathway via Sho1 osmosensor|signal transduction involved in filamentous growth|cellular response to heat	SAM domain binding|protein kinase regulator activity	cytoplasm
YML053C_p	YML053C	hom	FT	NUCLEUS	0.0244263407955191	0.15721070020161	716	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YOL034W	SMC5	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0243884547110615	0.157917607081228	717	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair	DNA repair|resolution of recombination intermediates|recombinational repair|rDNA separation	damaged DNA binding|single-stranded DNA binding|ATPase activity	Smc5-Smc6 complex|nucleus
YNL082W	PMS1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.0243880262818234	0.157800924389545	718	ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL	mismatch repair|meiotic mismatch repair	double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding	nucleus|MutLalpha complex|cytoplasm
YLR342W-A_p	YLR342W-A	hom			0.0243684762536977	0.158134451421348	719	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL307C	MCK1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION	0.0243561209633679	0.158345509939426	720	Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family	meiosis|double-strand break repair via nonhomologous end joining|ascospore formation|protein phosphorylation|response to stress|mitotic sister chromatid segregation	protein serine/threonine/tyrosine kinase activity|protein serine/threonine kinase activity|protein kinase activity	cellular_component
YGL146C_p	RRT6	hom			0.0243304412692003	0.158784863762049	721	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins	biological_process	molecular_function	membrane
YBR153W	RIB7	het	FT	OXIDATION-REDUCTION PROCESS	0.0243112563298231	0.15911370027445	722	Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway	riboflavin biosynthetic process	5-amino-6-(5-phosphoribosylamino)uracil reductase activity	cellular_component
YOR042W	CUE5	hom			0.0242766790874823	0.159707666529128	723	Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	ubiquitin binding	cytoplasm
YPL091W	GLR1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|MITOCHONDRION	0.0242750042702089	0.159736478964198	724	Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress|protein glutathionylation	glutathione-disulfide reductase activity	mitochondrion|nucleus|cytoplasm
YBR167C	POP7	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0242519935880467	0.160132737282837	725	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YBL036C	YBL036C	hom			0.024234360230966	0.160436897085805	726	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS	biological_process	pyridoxal phosphate binding	cellular_component
YPR092W_d	YPR092W	hom			0.0242175649880612	0.161039323097481	727	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR233C	PHO81	hom	FT	LIPID METABOLISM|NUCLEUS	0.0242132976938318	0.160800778996489	728	Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress	phosphate-containing compound metabolic process	cyclin-dependent protein kinase inhibitor activity	nucleus|cytoplasm
YLR257W	YLR257W	hom			0.0242076793072216	0.160897948942799	729	Protein of unknown function; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cytoplasm
YPR146C_d	YPR146C	hom			0.0241625727991095	0.161679673238745	730	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL056W	MBP1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS	0.0241227912839993	0.16237148765609	731	Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes	positive regulation of transcription involved in G1/S phase of mitotic cell cycle	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	MBF transcription complex|nucleus
YDL006W	PTC1	hom	FF|FT	RNA PROCESSING|SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0241033659061274	0.1634012368502	732	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation	mitochondrion inheritance|inactivation of MAPK activity involved in osmosensory signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|tRNA splicing, via endonucleolytic cleavage and ligation|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YNL246W	VPS75	hom	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.024095728610384	0.162843391437252	733	NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress	double-strand break repair via nonhomologous end joining|nucleosome assembly|positive regulation of histone acetylation	histone binding|acetyltransferase activator activity	chromatin|nucleus
YHR017W	YSC83	hom	FT	MITOCHONDRION	0.0240762731182537	0.163371641161779	734	Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YDR350C	ATP22	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.024056430295136	0.163718997128505	735	Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane	proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrial inner membrane
YJL025W	RRN7	het	FT	NUCLEUS	0.0240467846716461	0.163950961581688	736	Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p	transcription initiation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	TBP-class protein binding|RNA polymerase I CORE element sequence-specific DNA binding|RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity	nucleolus|RNA polymerase I core factor complex
YOR298C-A	MBF1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION	0.0240328663368722	0.164006402828716	737	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress	positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity	mitochondrion|nucleus
YKL117W	SBA1	hom	FT	NUCLEUS	0.024025036213547	0.164143847376997	738	Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress	protein folding|positive regulation of telomere maintenance via telomerase|regulation of telomerase activity	chaperone binding	nucleus|cytoplasm
YGL250W	RMR1	hom	FT	CELL CYCLE|NUCLEUS	0.0240037015107138	0.164455845758105	739	Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus	meiotic gene conversion|reciprocal meiotic recombination	molecular_function	nucleus|cytoplasm
YNL242W	ATG2	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	0.0239909307337092	0.164680555606209	740	Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress	mitochondrion degradation|piecemeal microautophagy of nucleus|peroxisome degradation|CVT pathway|autophagic vacuole assembly	molecular_function	pre-autophagosomal structure|cytoplasm|extrinsic to membrane
YLR323C	CWC24	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0239783888812028	0.164901462235874	741	Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p	generation of catalytic spliceosome for first transesterification step|snoRNA splicing	molecular_function	nucleus|U2-type spliceosomal complex
YFR027W	ECO1	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0239658290717092	0.165122908558294	742	Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress	double-strand break repair|regulation of DNA replication|mitotic chromosome condensation|internal peptidyl-lysine acetylation|establishment of mitotic sister chromatid cohesion|DNA repair|chromosome organization|DNA replication|regulation of mitosis|telomere organization|tRNA gene clustering	acetyltransferase activity|chromatin binding	nuclear chromatin|nuclear replication fork
YER043C	SAH1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0239621154578703	0.165251465214689	743	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor	methionine metabolic process|selenocysteine metabolic process	adenosylhomocysteinase activity	cytoplasm
YPL026C	SKS1	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0239407831740323	0.165565169250108	744	Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway	glucose transport|protein phosphorylation|response to glucose stimulus|positive regulation of transcription from RNA polymerase II promoter	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YHL008C_p	YHL008C	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.0239354603401545	0.165848665101722	745	Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	chloride transport|monocarboxylic acid transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|fungal-type vacuole
YCL024W	KCC4	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0238986994763436	0.166310288793678	746	Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication	budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly	phosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|protein kinase activity	incipient cellular bud site|cellular bud neck septin collar|plasma membrane|cellular bud neck|septin ring
YJL009W_d	YJL009W	het			0.0238644996593102	0.166917673224963	747	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex	Unknown	Unknown	Unknown
YMR211W	DML1	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0238608910236173	0.166981859206046	748	Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family	plasmid maintenance|mitochondrial genome maintenance	molecular_function	mitochondrion|cytoplasm
YOL037C_d	YOL037C	hom			0.0238385318198724	0.16744330780119	749	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W	Unknown	Unknown	Unknown
YHL033C	RPL8A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0238237488943903	0.167643575640063	750	Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR153W_p	YGR153W	hom			0.0237959242575453	0.168204021484977	751	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKR071C	DRE2	het	FT	COFACTOR METABOLISM|MITOCHONDRION	0.0237121573578294	0.169643509273	752	Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress	iron-sulfur cluster assembly	electron carrier activity	cytosol|cytoplasm|mitochondrial intermembrane space
YLR150W	STM1	hom	FT	SIGNALING|TRANSLATION|NUCLEUS|RIBOSOME	0.0236549060796508	0.170676476339911	753	Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery	translational elongation|TOR signaling cascade|regulation of translational initiation in response to stress|telomere maintenance|anti-apoptosis	triplex DNA binding|DNA binding|telomeric DNA binding	cytosolic ribosome|polysome|cytoplasm
YMR062C	ARG7	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|MITOCHONDRION	0.0236427582410735	0.170960064449256	754	Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine	fungal-type cell wall organization|ornithine biosynthetic process|arginine biosynthetic process	acetyl-CoA:L-glutamate N-acetyltransferase activity|glutamate N-acetyltransferase activity	mitochondrion|mitochondrial matrix
YPL069C	BTS1	hom	FF|FT	PROTEIN LOCALIZATION|LIPID METABOLISM|MITOCHONDRION	0.0236390892606608	0.171473951082797	755	Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic	terpenoid biosynthetic process	farnesyltranstransferase activity	mitochondrion
YOR201C	MRM1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION	0.0236232152616208	0.171250285242488	756	Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA	rRNA modification	rRNA (guanine-N1-)-methyltransferase activity	mitochondrion
YGL112C	TAF6	het	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE	0.0236208445951596	0.171293267619059	757	Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4	histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter	chromatin binding|RNA polymerase II activating transcription factor binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YOR192C	THI72	hom			0.0235979234595743	0.171965068123928	758	Transporter of thiamine or related compound; shares sequence similarity with Thi7p	thiamine transport	transporter activity	integral to membrane|membrane
YKR061W	KTR2	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0235931687147823	0.171795654391929	759	Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication	cell wall mannoprotein biosynthetic process|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YMR112C	MED11	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0235111290804132	0.173291355717114	760	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	TFIIH-class transcription factor binding|TFIIH-class transcription factor recruiting transcription factor activity	core mediator complex
YBR277C_d	YBR277C	hom			0.0235019076140776	0.17346008274148	761	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W	Unknown	Unknown	Unknown
YHR139C	SPS100	hom	FT	KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS	0.0234906936517574	0.173665432180879	762	Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin	ascospore wall assembly	molecular_function	ascospore wall
YEL017W	GTT3	hom	FT	ENDOMEMBRANE SYSTEM|NUCLEUS	0.0234470032135315	0.174467220803469	763	Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery	biological_process	molecular_function	cellular_component
YAL014C	SYN8	hom	FT	PROTEIN LOCALIZATION	0.0233630254555704	0.176016098550793	764	Endosomal SNARE related to mammalian syntaxin 8	transport	SNAP receptor activity	endosome
YOL102C	TPT1	het	FT	RNA PROCESSING|NUCLEUS	0.0233456617315466	0.176337628123107	765	tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide	tRNA splicing, via endonucleolytic cleavage and ligation	tRNA 2'-phosphotransferase activity	nucleus|cytoplasm
YFL008W	SMC1	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0233308816200126	0.177452657204061	766	Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure	double-strand break repair|mitotic sister chromatid cohesion|mitotic sister chromatid segregation	double-stranded DNA binding|ATPase activity|AT DNA binding|DNA secondary structure binding	nuclear mitotic cohesin complex
YGR275W	RTT102	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|RSC COMPLEX	0.0232847984917722	0.177468107600643	767	Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress	chromosome segregation|nucleosome disassembly|chromatin remodeling|transcription elongation from RNA polymerase II promoter	molecular_function	RSC complex|SWI/SNF complex|nucleus
YHL014C	YLF2	hom	FT	MITOCHONDRION	0.0232680390452416	0.177780344368082	768	Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	GTP binding	mitochondrion
YBL062W_d	YBL062W	hom			0.0232598710337352	0.177932666547978	769	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNR003C	RPC34	het	FT	NUCLEUS|MITOCHONDRION	0.0232536988992453	0.17804783276593	770	RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	mitochondrion|DNA-directed RNA polymerase III complex|nucleus|cytoplasm
YGR251W	NOP19	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0232333075448617	0.17842871051252	771	Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleoplasm|nucleolus|nucleus|90S preribosome
YPL233W	NSL1	het	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.023223409180367	0.178613814390409	772	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation	chromosome segregation	molecular_function	nuclear MIS12/MIND type complex|kinetochore|spindle pole
YCR100C_p	YCR100C	hom			0.0231983858705333	0.17908239831498	773	Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YJR012C_p	YJR012C	het			0.0231856229054404	0.179321747890832	774	Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W	biological_process	molecular_function	cellular_component
YNL279W	PRM1	hom	FT	MEMBRANE ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0231373809327734	0.180293564610187	775	Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p	plasma membrane fusion involved in cytogamy|response to pheromone	molecular_function	integral to membrane|mating projection tip
YLR078C	BOS1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.023130555269008	0.180357182025287	776	v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi	ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|ER to Golgi transport vesicle membrane|endoplasmic reticulum membrane
YKL203C	TOR2	het	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION|MITOCHONDRION|PLASMA MEMBRANE	0.0231139030513083	0.180671165381362	777	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication	G1 phase of mitotic cell cycle|regulation of cell cycle|actin filament reorganization involved in cell cycle|positive regulation of endocytosis|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity|Rho protein signal transduction|ribosome biogenesis|signal transduction|TOR signaling cascade|cytoskeleton organization|negative regulation of autophagy	protein binding|protein serine/threonine kinase activity	TORC1 complex|TORC2 complex|mitochondrion|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|plasma membrane|cytoplasm
YKL155C	RSM22	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.023095660717866	0.181210853724062	778	Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase	mitochondrial translation	structural constituent of ribosome|S-adenosylmethionine-dependent methyltransferase activity	mitochondrion|mitochondrial small ribosomal subunit
YNL051W	COG5	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0230915234983088	0.181680364882175	779	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YDL120W	YFH1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|COFACTOR METABOLISM|MITOCHONDRION	0.0230271350236899	0.182313774303841	780	Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia	cellular iron ion homeostasis|iron-sulfur cluster assembly|glutathione metabolic process	ferrous iron binding|ferroxidase activity|iron chaperone activity	mitochondrion|mitochondrial matrix
YER140W	EMP65	hom	FT	MITOCHONDRION	0.0230268221075716	0.182319718097617	781	ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	protein folding in endoplasmic reticulum	molecular_function	mitochondrion|integral to membrane
YOR014W	RTS1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CHROMOSOME SEGREGATION|NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON	0.0229840764976527	0.183198320149613	782	B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A	mitotic cell cycle spindle orientation checkpoint|cellular protein localization|meiotic sister chromatid cohesion, centromeric|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|spindle pole body|condensed nuclear chromosome, centromeric region|cellular bud neck|cytoplasm
YKL165C	MCD4	het	FF|FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0229720443305777	0.183362428352667	783	Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes	GPI anchor biosynthetic process|ATP transport	mannose-ethanolamine phosphotransferase activity	integral to membrane|fungal-type cell wall|endoplasmic reticulum|fungal-type vacuole
YBR298C	MAL31	hom	FT	CARBOHYDRATE METABOLISM	0.0229679365047213	0.183964279844707	784	Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C	alpha-glucoside transport|transmembrane transport	alpha-glucoside:hydrogen symporter activity	integral to membrane|membrane
YMR241W	YHM2	hom	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.0229335287966227	0.184098222170708	785	Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome	tricarboxylic acid transport|mitochondrial citrate transport|alpha-ketoglutarate transport|mitochondrial genome maintenance	tricarboxylate secondary active transmembrane transporter activity|DNA binding	mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YNL236W	SIN4	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0229081153251009	0.185175121635176	786	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding	core mediator complex
YML094C-A_d	YML094C-A	hom	FF		0.0228720469185536	0.185277285517061	787	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YDR169C-A_p	YDR169C-A	hom			0.0228719163283918	0.185279795826463	788	Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YGR033C	TIM21	hom	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0228484207390627	0.185731856360071	789	Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity	protein import into mitochondrial matrix	molecular_function	mitochondrion|mitochondrial inner membrane presequence translocase complex
YDR036C	EHD3	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0227982135294624	0.186700585684193	790	3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis	fatty acid beta-oxidation|biological_process	3-hydroxyisobutyryl-CoA hydrolase activity	mitochondrion
YOL149W	DCP1	het	FT	RNA PROCESSING	0.0227393629241934	0.187840829812224	791	Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA	mRNA binding|enzyme activator activity|m7G(5')pppN diphosphatase activity	cytoplasmic mRNA processing body
YBL102W	SFT2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0227104199702245	0.188403487153253	792	Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5	Golgi to endosome transport	molecular_function	integral to membrane|Golgi membrane
YCL069W	VBA3	hom			0.0227023106741902	0.188627268548798	793	Permease of basic amino acids in the vacuolar membrane	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YLR305C	STT4	het	FT	LIPID METABOLISM|SIGNALING|MITOCHONDRION|PLASMA MEMBRANE	0.0226167181032786	0.190233595046588	794	Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization	phosphatidylinositol phosphorylation	1-phosphatidylinositol 4-kinase activity	mitochondrion|plasma membrane
YKL036C_d	YKL036C	het			0.0225862242251448	0.190831989802117	795	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W	Unknown	Unknown	Unknown
YFL041W	FET5	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0225801375366383	0.191150183405218	796	Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport	iron ion transport	ferroxidase activity	fungal-type vacuole membrane|integral to membrane
YMR268C	PRP24	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0225659852047235	0.191229912904552	797	Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling	assembly of spliceosomal tri-snRNP|spliceosomal complex assembly	U6 snRNA binding|snRNA binding	U6 snRNP
YML084W_d	YML084W	hom			0.0225270293580141	0.191997548219433	798	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL040C	ISM1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0224535920202641	0.19345080553034	799	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth	isoleucyl-tRNA aminoacylation|mitochondrial isoleucyl-tRNA aminoacylation|mitochondrial translation	isoleucine-tRNA ligase activity	mitochondrion
YER028C	MIG3	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0224218537511071	0.19408136963644	800	Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication	cellular response to UV|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|response to DNA damage stimulus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nuclear chromatin
YEL011W	GLC3	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0224105039328679	0.194307229261952	801	Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	glycogen biosynthetic process	1,4-alpha-glucan branching enzyme activity	cytoplasm
YPL035C_d	YPL035C	hom			0.0223903315983173	0.19504218996346	802	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene	Unknown	Unknown	Unknown
YGR292W	MAL12	hom	FT	CARBOHYDRATE METABOLISM	0.0223575262225023	0.195697418054846	803	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose	sucrose catabolic process|maltose catabolic process	sucrose alpha-glucosidase activity|maltose alpha-glucosidase activity	plasma membrane
YGR207C	CIR1	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0223442188046061	0.195630145118381	804	Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YGR141W	VPS62	hom	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	0.0223430680754241	0.195653169457977	805	Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins	protein targeting to vacuole	molecular_function	cellular_component
YNL170W_d	YNL170W	hom			0.0223369275354114	0.195776065883995	806	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL058W	PCM1	het	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEUS	0.0223361265784918	0.19579210035976	807	Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors	fungal-type cell wall chitin biosynthetic process	phosphoacetylglucosamine mutase activity	nucleus|cytoplasm
YLR249W	YEF3	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEOTIDE METABOLISM|RIBOSOME	0.0223324647429424	0.195865419444463	808	Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication	translational elongation|translational termination	ATPase activity|translation elongation factor activity	cytosolic ribosome|ribosome
YDR190C	RVB1	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0223283805623522	0.196214111768211	809	ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly	regulation of transcription from RNA polymerase II promoter|box C/D snoRNP assembly|chromatin remodeling|histone exchange	ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 3'-5' DNA helicase activity	ASTRA complex|R2TP complex|Swr1 complex|nucleus|Ino80 complex
YOR009W	TIR4	hom	FT	CELL WALL ORG/BIOGENESIS	0.0222813408192531	0.196891149333942	810	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock	biological_process	molecular_function	fungal-type cell wall
YPL036W	PMA2	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION|PLASMA MEMBRANE	0.0222776081436855	0.196966193952851	811	Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential	proton transport|regulation of pH	hydrogen-exporting ATPase activity, phosphorylative mechanism	mitochondrion|integral to membrane|plasma membrane
YLL014W	EMC6	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0222406945551167	0.198044017650967	812	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|integral to membrane|endoplasmic reticulum
YGR104C	SRB5	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0222180103021308	0.198167232035179	813	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance	transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly	core mediator complex
YBR273C	UBX7	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0222071856767307	0.198385947275091	814	UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication	sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process	molecular_function	nuclear envelope|endoplasmic reticulum
YGL064C	MRH4	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|MITOCHONDRION	0.022192102464815	0.198691002852917	815	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function	RNA metabolic process	RNA helicase activity	mitochondrion
YER048W-A	ISD11	het	FT	COFACTOR METABOLISM|MITOCHONDRION	0.0221734005937997	0.199069721057084	816	Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis	iron-sulfur cluster assembly	enzyme activator activity	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YHR205W	SCH9	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|CHROMOSOME	0.0221437196322993	0.199671851067531	817	AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan	protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|regulation of protein localization|positive regulation of transcription from RNA polymerase III promoter|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase I promoter|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of cell size|regulation of response to osmotic stress	protein serine/threonine kinase activity	chromatin|fungal-type vacuole membrane|nucleus|cytoplasm
YJR145C	RPS4A	hom	FT	TRANSLATION|RIBOSOME	0.0220877925810437	0.201011592507432	818	Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasm|90S preribosome
YDL131W	LYS21	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS|MITOCHONDRION	0.0220638354045633	0.201299045267596	819	Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication	lysine biosynthetic process via aminoadipic acid	homocitrate synthase activity	nucleus
YMR141C_d	YMR141C	hom			0.022051702550224	0.201547027587195	820	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR200C	ELP2	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.0219445923613835	0.203745908841028	821	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin	regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YOR355W	GDS1	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS|MITOCHONDRION	0.0219426532544501	0.203785877271039	822	Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	aerobic respiration	molecular_function	mitochondrion|nucleus|cytoplasm
YER067C-A_d	YER067C-A	hom			0.0218342331725029	0.206029691045202	823	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W	Unknown	Unknown	Unknown
YBR116C_d	YBR116C	hom			0.0217453935513314	0.207881605006411	824	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2	Unknown	Unknown	Unknown
YIL016W	SNL1	hom	FT	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0217382984972921	0.208030024222647	825	Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein	protein folding|nuclear pore organization	ribosome binding	nuclear envelope|mitochondrion|cytosolic ribosome|endoplasmic reticulum membrane|membrane
YOR230W	WTM1	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|GENE SILENCING|NUCLEUS	0.0217143812307038	0.208598766282186	826	Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats	negative regulation of chromatin silencing at silent mating-type cassette|maintenance of protein location in nucleus|negative regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of chromatin silencing at telomere|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter	protein binding|transcription corepressor activity	nucleus
YCL075W	YCL075W	hom	FT	NUCLEUS	0.0217017058104119	0.208796714801033	827	Pseudogene: encodes fragment of Ty Pol protein	transposition, RNA-mediated	ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity	retrotransposon nucleocapsid
YML081C-A	ATP18	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.0215421092180413	0.212164515439789	828	Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms	mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YJR058C	APS2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE	0.0215104425105139	0.212837383156751	829	Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YAL061W_p	BDH2	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEUS	0.0214126282130293	0.214925506079823	830	Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3	biological_process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	nucleus|cytoplasm
YDR361C	BCP1	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0214082966382349	0.215223591499523	831	Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport	protein export from nucleus|ribosomal large subunit export from nucleus	molecular_function	nucleus|cytoplasm
YKL189W	HYM1	het	FT	CELL DIVISION|SITE OF POLARIZED GROWTH	0.0214032147451805	0.215127238999014	832	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response	cytokinesis, completion of separation|regulation of cell shape|regulation of transcription, DNA-dependent|budding cell apical bud growth	molecular_function	incipient cellular bud site|intracellular|cellular bud|mating projection tip
YMR267W	PPA2	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0213962461002979	0.215413532437834	833	Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate	aerobic respiration	inorganic diphosphatase activity	mitochondrion
YBR279W	PAF1	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING|NUCLEUS|CHROMOSOME|RNA POL II, HOLOENZYME	0.0213746011328903	0.215741272972445	834	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1	negative regulation of DNA recombination|mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of transcription-coupled nucleotide-excision repair|rRNA processing|transcription elongation from RNA polymerase I promoter|regulation of chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin silencing at rDNA|Unknown|snoRNA 3'-end processing|transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity	transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YPL102C_d	YPL102C	hom			0.0213534226204147	0.216196565209431	835	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4	Unknown	Unknown	Unknown
YER057C	HMF1	hom	FT	NUCLEUS	0.0213466754002223	0.216341760982962	836	Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro	biological_process	molecular_function	cytosol|nucleus|cytoplasm
YOR151C	RPB2	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION|RNA POL II, HOLOENZYME	0.0213106041482682	0.217119181011771	837	RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit	transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	mitochondrion|DNA-directed RNA polymerase II, core complex
YJR106W	ECM27	hom	FT	CELL WALL ORG/BIOGENESIS	0.0212929270095212	0.217500897329821	838	Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p	fungal-type cell wall organization	molecular_function	integral to membrane
YCR071C	IMG2	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0212817176233012	0.218155270403521	839	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YNR006W	VPS27	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	0.0212662151349636	0.218628463009032	840	Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)	protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding|phosphatidylinositol-3-phosphate binding	endosome|ESCRT-0 complex
YBR236C	ABD1	het	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS|RNA POL II, HOLOENZYME	0.0211946511729953	0.219631841252942	841	Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA	7-methylguanosine mRNA capping|transcription from RNA polymerase II promoter	mRNA (guanine-N7-)-methyltransferase activity	nucleus|DNA-directed RNA polymerase II, holoenzyme
YIL140W	AXL2	hom	FT	CELL CYCLE|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON	0.0211887857310326	0.21975949535915	842	Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate	axial cellular bud site selection|cellular bud site selection	molecular_function	integral to plasma membrane|cellular bud neck|septin ring
YJL194W	CDC6	het	FT	CELL CYCLE|CELL DIVISION|GENE SILENCING|NUCLEUS|PLASMA MEMBRANE	0.0211743810066841	0.220073222243835	843	Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of DNA-dependent DNA replication initiation|regulation of chromatin silencing at telomere|pre-replicative complex assembly|G1/S transition of mitotic cell cycle	DNA replication origin binding|protein binding|chromatin binding|ATPase activity|GTP binding|GTPase activity|ATP binding	DNA replication preinitiation complex|pre-replicative complex
YFL004W	VTC2	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM	0.0211452405242245	0.221122287307436	844	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion	polyphosphate metabolic process|vacuolar transport|microautophagy|protein localization|vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex
YOR048C	RAT1	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION	0.0211444846746864	0.220931970461594	845	Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination	termination of RNA polymerase II transcription, exosome-dependent|nuclear mRNA surveillance|termination of RNA polymerase II transcription, poly(A)-coupled|rRNA processing|RNA processing	5'-3' exoribonuclease activity	mitochondrion|nucleus
YGL179C	TOS3	hom	FT	CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	0.0211440788406433	0.220734234783416	846	Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome	protein phosphorylation|glucose metabolic process	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YER037W	PHM8	hom	FT	RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0211134267723849	0.221404326622441	847	Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p	cellular response to phosphate starvation	lysophosphatidic acid phosphatase activity	nucleus|cytoplasm
YPL001W	HAT1	hom	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0210676948552534	0.222406789198477	848	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair	histone acetylation|chromatin silencing at telomere	histone acetyltransferase activity|histone binding	histone acetyltransferase complex|nucleus|cytoplasm
YKL006C-A	SFT1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0210582559564641	0.222614097550293	849	Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment	intra-Golgi vesicle-mediated transport|vesicle fusion	SNAP receptor activity	SNARE complex|Golgi membrane
YPL187W	MF(ALPHA)1	hom	FT	SIGNALING	0.0210489469704004	0.222818687992927	850	Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YMR269W	TMA23	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0210418079118504	0.22297567945141	851	Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan	ribosomal small subunit biogenesis	molecular_function	ribosome|nucleolus
YOR223W	YOR223W	hom	FT	ENDOPLASMIC RETICULUM	0.0210398176351481	0.223019460729176	852	Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3	biological_process	molecular_function	fungal-type vacuole lumen|endoplasmic reticulum
YBR088C	POL30	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0210341135472497	0.223144970941666	853	Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair	lagging strand elongation|postreplication repair|base-excision repair|nucleotide-excision repair|mismatch repair|meiotic mismatch repair|leading strand elongation|chromatin silencing at telomere|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette	DNA polymerase processivity factor activity	PCNA complex|nucleus|replication fork
YGR101W	PCP1	hom	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0210198887152421	0.22345818787113	854	Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases	signal peptide processing|regulation of mitochondrion organization	serine-type endopeptidase activity	integral to membrane|mitochondrial inner membrane
YDR279W	RNH202	hom	FT	NUCLEUS	0.0210133144167862	0.223603053677221	855	Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome	RNA catabolic process|DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus
YOR286W	RDL2	hom	FT	MITOCHONDRION	0.0210039575509299	0.223809349599932	856	Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	thiosulfate sulfurtransferase activity	mitochondrion
YLR079W	SIC1	hom	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0209575843373158	0.224833773053078	857	Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1	regulation of cyclin-dependent protein kinase activity|negative regulation of macroautophagy|G1/S transition of mitotic cell cycle	cyclin-dependent protein kinase inhibitor activity	nucleus|cytoplasm
YML047C	PRM6	hom			0.0209482311789136	0.225040797379354	858	Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family	biological_process	molecular_function	integral to membrane
YKL205W	LOS1	hom	FT	RNA PROCESSING|RNA LOCALIZATION|NUCLEUS|MITOCHONDRION	0.0209163940909332	0.22595418762125	859	Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus	tRNA binding|Ran GTPase binding	mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YOR186W_p	YOR186W	hom			0.020852758697153	0.227161789075981	860	Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YPL258C	THI21	hom			0.0208024523073195	0.228285096301513	861	Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p	thiamine biosynthetic process	phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity	cellular_component
YBR043C	QDR3	hom	FT	PLASMA MEMBRANE	0.0207977167235091	0.22839104194475	862	Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin	drug transmembrane transport|polyamine homeostasis	drug transmembrane transporter activity|polyamine transmembrane transporter activity	integral to membrane|plasma membrane
YER086W	ILV1	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0207861223643765	0.228650581537449	863	Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation	threonine catabolic process|isoleucine biosynthetic process	L-threonine ammonia-lyase activity	mitochondrion
YLL015W	BPT1	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	0.0206836872347515	0.231022265501816	864	ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p	cadmium ion transport|bilirubin transport	bilirubin transmembrane transporter activity|cadmium ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YLR313C	SPH1	hom	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0206158556350232	0.232486195337698	865	Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p	bipolar cellular bud site selection|pseudohyphal growth|invasive filamentous growth|mating projection assembly	molecular_function	incipient cellular bud site|cellular bud neck|cellular bud tip|mating projection
YHR066W	SSF1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0206001305625642	0.233121567747911	866	Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication	conjugation with cellular fusion|ribosomal large subunit assembly|regulation of cell size	rRNA binding	nucleolus
YML016C	PPZ1	hom	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|NUCLEUS|PLASMA MEMBRANE	0.0205952299979235	0.233023591935832	867	Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular sodium ion homeostasis|cellular protein localization|protein dephosphorylation	protein serine/threonine phosphatase activity	extrinsic to plasma membrane|nucleus|cytoplasm
YLR366W_d	YLR366W	hom			0.0205687008453051	0.233626197321237	868	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A	Unknown	Unknown	Unknown
YDR110W	FOB1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0205217385996898	0.234625858572881	869	Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases	extrachromosomal circular DNA accumulation involved in cell aging|negative regulation of DNA replication|rDNA condensation|chromatin silencing at rDNA|replicative cell aging|protein localization to nucleolar rDNA repeats|DNA recombination	rDNA spacer replication fork barrier binding	nucleolus|rDNA heterochromatin
YLR045C	STU2	het	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.0204934547388183	0.235271581567842	870	Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p	microtubule nucleation|mitotic spindle organization in nucleus	microtubule binding|structural constituent of cytoskeleton	cell cortex|spindle microtubule|condensed nuclear chromosome kinetochore|spindle pole body|kinetochore
YLR174W	IDP2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	0.0204642158786584	0.236150096147022	871	Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication	glutamate biosynthetic process|isocitrate metabolic process	isocitrate dehydrogenase (NADP+) activity	cytosol
YGR023W	MTL1	hom	FT	CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS|PLASMA MEMBRANE	0.0204312282273712	0.237256620664032	872	Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p	cellular response to glucose starvation|fungal-type cell wall organization|cellular response to oxidative stress	molecular_function	integral to plasma membrane
YOR105W_p	YOR105W	hom			0.020416273570471	0.23704002816007	873	Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YMR121C	RPL15B	hom	FT	TRANSLATION|RIBOSOME	0.0204129915796272	0.237115435761774	874	Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YKL175W	ZRT3	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.0204114485307937	0.237150894979996	875	Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency	cellular zinc ion homeostasis|zinc ion transport	zinc ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YJL101C	GSH1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS	0.0203775305985856	0.238562018192174	876	Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress	response to cadmium ion|response to hydrogen peroxide|glutathione biosynthetic process	glutamate-cysteine ligase activity	intracellular
YPR112C	MRD1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0203625713178198	0.238276030796355	877	Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|small-subunit processome assembly|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|90S preribosome
YMR132C_p	JLP2	hom			0.0202540193701542	0.241279862651024	878	Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)	biological_process	molecular_function	cytoplasm
YNL177C	MRPL22	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0202525297934678	0.240822919404611	879	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YCR023C	YCR023C	hom			0.020243827454167	0.241235701200704	880	Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YGL015C_p	YGL015C	hom			0.0202119508083583	0.241766931283401	881	Putative protein of unknown function; null mutants accumulate cargo in the Golgi	biological_process	molecular_function	cellular_component
YCR095C_p	OCA4	hom			0.020200320638078	0.242037969791841	882	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts	biological_process	molecular_function	cytoplasm
YOR219C	STE13	hom	FT	PROTEOLYSIS|GOLGI APPARATUS	0.0201692787022536	0.242762441230913	883	Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor	peptide pheromone maturation	aminopeptidase activity	trans-Golgi network
YAL065C_p	YAL065C	hom			0.0201587092080292	0.243009464548719	884	Putative protein of unknown function; has homology to FLO1; possible pseudogene	biological_process	molecular_function	cellular_component
YBR294W	SUL1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0201485651434447	0.243527985442691	885	High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates	sulfate transport|transmembrane transport	sulfate transmembrane transporter activity	integral to membrane|plasma membrane
YNL022C_p	YNL022C	hom	FT	NUCLEUS	0.020147195304854	0.243278760905085	886	Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis	biological_process	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YER050C	RSM18	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0201464387199518	0.243296463853836	887	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YJL197W	UBP12	hom	FT	PROTEOLYSIS|NUCLEUS	0.0201431354871934	0.243373765131933	888	Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm	biological_process	ubiquitin-specific protease activity	nucleus|cytoplasm
YMR105C	PGM2	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0201202434516217	0.244261784330803	889	Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress	glucose 6-phosphate metabolic process|cellular calcium ion homeostasis|galactose catabolic process|cellular cation homeostasis|glucose 1-phosphate metabolic process|trehalose biosynthetic process|UDP-glucose metabolic process|glycogen biosynthetic process	phosphoglucomutase activity	cytoplasm
YBL013W	FMT1	hom	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION	0.0200983430955496	0.244423686756687	890	Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate	translational initiation|methionyl-tRNA aminoacylation	methionyl-tRNA formyltransferase activity	mitochondrion
YEL029C	BUD16	hom	FT	CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM|NUCLEUS	0.0200822489842548	0.244872067694203	891	Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)	pyridoxal phosphate biosynthetic process|cellular bud site selection	pyridoxal kinase activity	cytoplasm
YMR137C	PSO2	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0200818338951914	0.244811458444561	892	Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress	DNA repair|double-strand break repair	damaged DNA binding|5'-3' exonuclease activity	nucleus
YCR001W_d	YCR001W	hom			0.0200801106517888	0.244851959220141	893	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene	Unknown	Unknown	Unknown
YDR044W	HEM13	het	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	0.0200413122236426	0.245976386647684	894	Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)	heme biosynthetic process	coproporphyrinogen oxidase activity	cytosol
YNL002C	RLP7	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS	0.020018455910115	0.246515502542114	895	Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs	ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rRNA binding	nucleolus|preribosome, large subunit precursor
YOR129C	AFI1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0199992120098935	0.246758582840081	896	Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p	asymmetric protein localization|actin cortical patch localization|cellular bud site selection	molecular_function	nucleus|plasma membrane|cellular bud neck|cytoplasm
YNL136W	EAF7	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0199855420809109	0.24708178049773	897	Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A	DNA repair|histone acetylation|regulation of transcription from RNA polymerase II promoter	molecular_function	histone acetyltransferase complex|nucleus|NuA4 histone acetyltransferase complex
YIR008C	PRI1	het	FT	NUCLEUS|CHROMOSOME	0.0199151325261312	0.24875116496049	898	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair	lagging strand elongation|DNA replication, synthesis of RNA primer|DNA replication initiation|DNA replication	single-stranded DNA binding|DNA primase activity	alpha DNA polymerase:primase complex|nuclear replication fork
YDR515W	SLF1	hom	FT	TRANSLATION|ION HOMEOSTASIS|ION HOMEOSTASIS	0.0198868936078494	0.249422909357447	899	RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cellular copper ion homeostasis|regulation of translation	RNA binding	polysome|cytoplasm
YPL220W	RPL1A	hom	FT	TRANSLATION|RIBOSOME	0.0198555159548788	0.250170802800217	900	Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YJL072C	PSF2	het	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0198496561903884	0.250381285898608	901	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery	double-strand break repair via break-induced replication|DNA-dependent DNA replication	molecular_function	GINS complex|replication fork protection complex|nuclear replication fork|nucleus|DNA replication preinitiation complex
YGL241W	KAP114	hom	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS	0.0197856699034938	0.251841216314655	902	Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress	protein import into nucleus|transcription factor import into nucleus	protein transporter activity	integral to membrane|nucleus|cytoplasm
YKL016C	ATP7	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION	0.0197349015217322	0.2530602439315	903	Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	protein complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase, stator stalk|integral to membrane|mitochondrial proton-transporting ATP synthase complex
YDR114C_p	YDR114C	hom			0.0197258806481475	0.253277278249871	904	Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium	biological_process	molecular_function	cellular_component
YDL049C	KNH1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.019725214376486	0.253364093547393	905	Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance	(1->6)-beta-D-glucan biosynthetic process	molecular_function	fungal-type cell wall|extracellular region
YEL049W	PAU2	hom			0.0196889159882478	0.254167968785429	906	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YGL150C	INO80	het	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0195633922464298	0.257208806024317	907	ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription	nucleosome positioning|histone exchange|transcription from RNA polymerase II promoter|DNA repair|nucleosome mobilization|chromatin remodeling|chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	ATPase activity|ATP-dependent 3'-5' DNA helicase activity	Ino80 complex
YKL011C	CCE1	hom	FT	MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0195392078574009	0.257797564995047	908	Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA	mitochondrial genome maintenance	endodeoxyribonuclease activity	mitochondrial inner membrane
YCR059C	YIH1	hom	FT	TRANSLATION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0195342742985477	0.258486315761626	909	Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT	negative regulation of protein phosphorylation	protein kinase inhibitor activity|ribosome binding|actin monomer binding	ribosome|nucleus|polysome|cytoplasm
YHR167W	THP2	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION|NUCLEUS	0.0195295797549794	0.258032217000332	910	Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance	mRNA export from nucleus|transcription elongation from RNA polymerase II promoter|DNA recombination	nucleic acid binding	THO complex part of transcription export complex|nucleoplasmic THO complex
YNL054W	VAC7	hom	FT	LIPID METABOLISM	0.0195212875895079	0.25823442874145	911	Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock	positive regulation of phosphatidylinositol biosynthetic process|positive regulation of kinase activity	molecular_function	fungal-type vacuole membrane|integral to membrane|PAS complex|vacuolar membrane|cytoplasm
YDR480W	DIG2	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0195066764772927	0.258591000727636	912	MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p	negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown	transcription factor binding	nucleus
YER139C	RTR1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0194982156390313	0.258939696724329	913	CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication	dephosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter	CTD phosphatase activity	nucleus|cytoplasm
YOR343C_d	YOR343C	hom			0.0194799589977106	0.259243900283925	914	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL162W	SUT1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0194356474936533	0.260329262441474	915	Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress	positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding	nucleus
YHR021W-A_p	ECM12	hom	FT	CELL WALL ORG/BIOGENESIS	0.019427971112013	0.260517606010768	916	Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity	fungal-type cell wall organization	molecular_function	cellular_component
YMR097C	MTG1	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0194261864658193	0.26105953628558	917	Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals	mitochondrial translation	GTPase activity	mitochondrion|mitochondrial inner membrane
YLR092W	SUL2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0193981908791689	0.261249169581004	918	High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates	sulfate transport	sulfate transmembrane transporter activity	integral to membrane|plasma membrane
YKL214C	YRA2	hom	FT	RNA LOCALIZATION|NUCLEUS	0.019370642409241	0.261927171999727	919	Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus	poly(A)+ mRNA export from nucleus	RNA binding	nucleus
YNR027W	BUD17	hom	FT	CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM|NUCLEUS	0.0193605115671496	0.262176810102334	920	Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)	pyridoxal phosphate biosynthetic process|cellular bud site selection	pyridoxal kinase activity	nucleus|cytoplasm
YHR058C	MED6	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0193562084260914	0.262567663999036	921	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress	RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly	core mediator complex
YGL076C	RPL7A	hom	FT	TRANSLATION|RIBOSOME	0.0193546729086588	0.262320757407843	922	Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit|cytoplasm
YNL081C	SWS2	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0193393642870419	0.262698437899307	923	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency	regulation of sporulation resulting in formation of a cellular spore|mitochondrial translation	structural constituent of ribosome	mitochondrial small ribosomal subunit|cytoplasm
YMR281W	GPI12	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0193380383021407	0.26308727511206	924	ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp	GPI anchor biosynthetic process	N-acetylglucosaminylphosphatidylinositol deacetylase activity	integral to membrane|endoplasmic reticulum membrane
YJL156C	SSY5	het	FT	PROTEOLYSIS|PLASMA MEMBRANE	0.0193076430090426	0.263553432296233	925	Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p	protein processing|response to amino acid stimulus	serine-type endopeptidase activity	extrinsic to plasma membrane
YGR097W	ASK10	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|RNA POL II, HOLOENZYME	0.0193013515699914	0.263637875726425	926	Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication	cellular protein catabolic process|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glycerol transport	molecular_function	DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YGL049C	TIF4632	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RIBOSOME	0.0192437913607894	0.265064811373319	927	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication	translational initiation|stress granule assembly	translation initiation factor binding|mRNA binding|translation initiation factor activity	eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YOR098C	NUP1	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0192419719873588	0.265110000762487	928	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153	poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YAL068C	PAU8	hom	FT	TRANSCRIPTION FROM RNA POL II	0.0192102796540093	0.265969311937424	929	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YMR228W	MTF1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0191672727771606	0.266969953024333	930	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation	transcription initiation from mitochondrial promoter	mitochondrial RNA polymerase binding promoter specificity activity	mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix|mitochondrial intermembrane space
YJR074W	MOG1	hom	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION|NUCLEUS	0.0191607164500114	0.267204960279552	931	Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p	protein import into nucleus	Ran GTPase binding	nucleus
YLR376C	PSY3	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0191137615261009	0.268307843996254	932	Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C	recombinational repair|error-free translesion synthesis	molecular_function	nucleus|Shu complex|cytoplasm
YLR451W	LEU3	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0191057783931081	0.268579211907284	933	Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation	negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YNL233W	BNI4	hom	FT	PROTEIN LOCALIZATION|CELL DIVISION|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0190833156857949	0.269071103793044	934	Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p	asymmetric protein localization|barrier septum assembly|chitin biosynthetic process	protein binding	incipient cellular bud site|cellular bud neck septin collar|cellular bud neck|septin ring
YBR090C_p	YBR090C	hom	FT	NUCLEUS	0.0190785713713443	0.269690485506179	935	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YPR137W	RRP9	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0190773244463125	0.269435755781727	936	Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein	rRNA modification|rRNA processing	snoRNA binding	box C/D snoRNP complex|small-subunit processome|nucleolus|90S preribosome
YJR097W	JJJ3	hom	FT	NUCLEUS	0.0190666291700698	0.269490056610655	937	Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	ferrous iron binding	nucleus|cytoplasm
YJL192C	SOP4	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0190331873844731	0.270331034759748	938	ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum
YDR156W	RPA14	hom	FT	NUCLEUS	0.0190291370941863	0.270433011514574	939	RNA polymerase I subunit A14	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size	molecular_function	DNA-directed RNA polymerase I complex
YJR077C	MIR1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.0190289749982154	0.270437093257288	940	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated	phosphate ion transmembrane transport	inorganic phosphate transmembrane transporter activity	mitochondrion|integral to membrane|integral to mitochondrial inner membrane
YPL225W	YPL225W	hom			0.0190141549401948	0.270810455900367	941	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|cytoplasm
YOR188W	MSB1	hom	FT	MITOCHONDRION|SITE OF POLARIZED GROWTH	0.0190120466855249	0.270863597966802	942	Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress	establishment of cell polarity	molecular_function	mitochondrion|cellular bud neck|cellular bud tip
YJR010C-A	SPC1	hom	FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0189580637912209	0.27222676016465	943	Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress	signal peptide processing|protein targeting to ER	molecular_function	signal peptidase complex
YLR090W	XDJ1	hom	FT	NUCLEUS|MITOCHONDRION	0.0189544769705311	0.272317499631938	944	Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	protein folding	chaperone binding	mitochondrion|integral to mitochondrial outer membrane|nucleus
YMR270C	RRN9	het	FT	NUCLEUS	0.0189084333818064	0.273698828161849	945	Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I	transcription of nuclear large rRNA transcript from RNA polymerase I promoter	TBP-class protein binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity	nucleolus|RNA polymerase I upstream activating factor complex
YML100W	TSL1	hom	FT	CARBOHYDRATE METABOLISM	0.0188693169478066	0.274836019411958	946	Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication	trehalose biosynthetic process|response to stress	enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YNL005C	MRP7	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0188564519831678	0.274876924019652	947	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome|peptidyltransferase activity	mitochondrion|mitochondrial large ribosomal subunit
YDR392W	SPT3	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0188531174277266	0.274890251325245	948	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters	conjugation with cellular fusion|histone acetylation|pseudohyphal growth|ascospore formation|chromatin modification|invasive growth in response to glucose limitation|transcription from RNA polymerase II promoter	transcription cofactor activity	SLIK (SAGA-like) complex|SAGA complex
YEL055C	POL5	het	FT	NUCLEUS	0.0188464456546335	0.27506017709781	949	DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA	rRNA transcription|DNA replication	DNA-directed DNA polymerase activity	nucleolus
YHR147C	MRPL6	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0188235238179486	0.276074470200402	950	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDL085C-A_p	YDL085C-A	hom	FT	NUCLEUS	0.0187538760720324	0.277425261809657	951	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YEL016C	NPP2	hom	FT	NUCLEOTIDE METABOLISM	0.0187470179721984	0.277816056781083	952	Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication	nucleoside triphosphate metabolic process	nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity	cellular_component
YOL112W	MSB4	hom	FT	SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH	0.0187276499921531	0.278097828440011	953	GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization	actin filament organization	Rab GTPase activator activity	incipient cellular bud site|polarisome|cellular bud tip
YGR050C_p	YGR050C	hom			0.0187122806877054	0.278492488730174	954	Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YML038C	YMD8	hom	FT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0186689538675172	0.279607105282016	955	Putative nucleotide sugar transporter, has similarity to Vrg4p	UDP-glucose transport|nucleotide-sugar transport	nucleotide-sugar transmembrane transporter activity	COPI-coated vesicle|integral to membrane
YML128C	MSC1	hom	FT	CELL CYCLE|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0186625212225847	0.279772848195742	956	Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated	reciprocal meiotic recombination	molecular_function	mitochondrion|endoplasmic reticulum|plasma membrane
YOR375C	GDH1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS	0.0185931141049778	0.281565430662212	957	NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication	glutamate biosynthetic process|ammonia assimilation cycle	glutamate dehydrogenase (NADP+) activity	nucleus|cytoplasm
YER064C	VHR2	hom	FT	NUCLEUS	0.0185869105366403	0.281726029042542	958	Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	regulation of transcription, DNA-dependent	molecular_function	nucleus
YOR018W	ROD1	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PLASMA MEMBRANE	0.0185840929549232	0.281798991290386	959	Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication	response to drug|ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	plasma membrane
YDL104C	QRI7	hom	FT	RNA PROCESSING|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0185617688045541	0.28237753576151	960	Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification	mitochondrial tRNA threonylcarbamoyladenosine modification	molecular_function	mitochondrion
YNL045W	LAP2	hom	FT	KETONE METABOLISM|LIPID METABOLISM|PROTEOLYSIS|NUCLEUS	0.0185612240494868	0.282391663487222	961	Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	cellular lipid metabolic process|protein catabolic process	aminopeptidase activity|leukotriene-A4 hydrolase activity|epoxide hydrolase activity	nucleus|cytoplasm
YMR301C	ATM1	het	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION	0.0185569261433347	0.282574916568628	962	Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol	cellular iron ion homeostasis	ATPase activity, coupled to transmembrane movement of substances|ATPase activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YJR047C	ANB1	hom	FT	KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|TRANSLATION|RIBOSOME	0.0185532012729471	0.282599782352988	963	Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication	translational frameshifting|positive regulation of translational termination|positive regulation of translational elongation	ribosome binding|RNA binding|translation elongation factor activity	cytosolic ribosome
YGL145W	TIP20	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0184716398755755	0.284721465242408	964	Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p	retrograde vesicle-mediated transport, Golgi to ER	molecular_function	Dsl1p complex|endoplasmic reticulum
YDR379W	RGA2	hom	FT	SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0184182994902501	0.286114837015957	965	GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p	budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|actin filament organization|pseudohyphal growth|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth	Rho GTPase activator activity	cellular bud neck split septin rings
YGL012W	ERG4	hom	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOPLASMIC RETICULUM	0.0183935686912615	0.286762421438457	966	C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol	ergosterol biosynthetic process	delta24(24-1) sterol reductase activity	integral to membrane|endoplasmic reticulum
YIL073C	SPO22	hom	FT	CELL CYCLE|NUCLEUS|CHROMOSOME	0.0183679787932442	0.288009216422339	967	Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis	regulation of synaptonemal complex assembly	molecular_function	condensed nuclear chromosome
YML107C	PML39	hom	FT	RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0183589134051969	0.287671545132936	968	Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes	maintenance of RNA location	molecular_function	ribosome|nuclear pore
YNR049C	MSO1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0183559981199059	0.288107766519208	969	Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress	cellular membrane fusion|ascospore-type prospore membrane assembly|vesicle docking involved in exocytosis	molecular_function	SNARE complex|cellular bud membrane|plasma membrane|prospore membrane|cellular bud neck|cellular bud tip
YDL174C	DLD1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0183536946216202	0.287808619420935	970	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane	cellular carbohydrate metabolic process|aerobic respiration	D-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial inner membrane
YOL128C	YGK3	hom	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION	0.018347112379646	0.288485277191982	971	Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation	proteolysis|protein phosphorylation|response to stress	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YDR494W	RSM28	hom	FT	TRANSLATION|MITOCHONDRION|RIBOSOME	0.0183330059536194	0.288352452214968	972	Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation	cytoplasmic translation|translational initiation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YKL170W	MRPL38	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.018320745526821	0.288675062587054	973	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YMR312W	ELP6	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.0183148393525552	0.289046345471116	974	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	protein urmylation|regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex
YFL029C	CAK1	het	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	0.0183036928036407	0.289124177508824	975	Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases	G2/M transition of mitotic cell cycle|meiosis|G1 phase of mitotic cell cycle|protein phosphorylation	cyclin-dependent protein kinase activating kinase activity	cytoplasm
YLR290C_p	YLR290C	hom	FT	MITOCHONDRION	0.0182958834818285	0.289330007401127	976	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene	biological_process	molecular_function	mitochondrion
YOR227W	HER1	hom	FT	MITOCHONDRION	0.0182787730194244	0.289781331791978	977	Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication	endoplasmic reticulum organization	molecular_function	mitochondrion|ribosome|cytoplasm
YOR385W_p	YOR385W	hom			0.0182737659177663	0.289913494180861	978	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene	biological_process	molecular_function	cytoplasm
YGR035W-A_p	YGR035W-A	hom			0.0182736391167678	0.289916841618216	979	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR495C	VPS3	hom	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	0.0182546488706042	0.290418461424664	980	Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase	vacuole inheritance|vacuolar acidification|protein targeting to vacuole	molecular_function	CORVET complex|cytoplasm
YOR012W_p	YOR012W	hom			0.0182420611713041	0.291039179922912	981	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YCR046C	IMG1	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0182296442723009	0.291439795068277	982	Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YER052C	HOM3	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0182256539955218	0.291473402537391	983	Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process	aspartate kinase activity	cytoplasm
YGR236C	SPG1	hom	FT	MITOCHONDRION	0.0181996074490425	0.291875655019669	984	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YNL042W	BOP3	hom	FT	NUCLEUS	0.0181845083974343	0.292564251383939	985	Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury	cellular response to methylmercury	molecular_function	nucleus|cytoplasm
YPL049C	DIG1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0181576744820099	0.292989099278366	986	MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p	negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown	DNA binding|transcription factor binding	nucleus
YLR385C	SWC7	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.0181400592707656	0.293457684167439	987	Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin	chromatin remodeling	molecular_function	Swr1 complex|nucleus
YPL139C	UME1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0181107233765728	0.29423916762925	988	Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter|regulation of meiosis	transcription corepressor activity	Rpd3S complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YEL036C	ANP1	hom	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0180992430293911	0.294545373732978	989	Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity|mannosyltransferase activity	alpha-1,6-mannosyltransferase complex|Golgi cis cisterna
YGR226C_d	YGR226C	hom			0.0180934322916977	0.294700440230567	990	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W	Unknown	Unknown	Unknown
YJR113C	RSM7	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0180743742059088	0.295713959713349	991	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YBL091C-A	SCS22	hom	FT	LIPID METABOLISM	0.0180711460574239	0.29529568209644	992	Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication	phospholipid biosynthetic process|chromatin silencing at telomere	molecular_function	cellular_component
YEL031W	SPF1	hom	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS	0.0180540253855105	0.296113820211377	993	P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1	cellular calcium ion homeostasis|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	mitochondrion|integral to membrane|endoplasmic reticulum membrane|cis-Golgi network
YMR032W	HOF1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0180218647694752	0.296614789514801	994	Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p	cytokinesis after mitosis|barrier septum assembly involved in cell cycle cytokinesis|response to DNA damage stimulus|cytokinesis	cytoskeletal protein binding	cellular bud neck contractile ring|cellular bud neck septin ring
YDL030W	PRP9	het	FT	RNA PROCESSING|NUCLEUS	0.0180188735547727	0.296911142383857	995	Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex	mRNA splicing, via spliceosome	RNA binding	U2 snRNP|U2-type prespliceosome
YDL183C	YDL183C	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.0180168505569902	0.297109608608057	996	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene	potassium ion transport|proton transport	molecular_function	integral to mitochondrial inner membrane
YDR003W	RCR2	hom	FT	VESICLE-MEDIATED TRANSPORT	0.0179974314519301	0.297774993953554	997	Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication	vesicle-mediated transport	molecular_function	vesicle|integral to membrane|fungal-type vacuole|cytoplasm
YDR024W_d	FYV1	hom			0.0179267611451847	0.299459923122522	998	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin	Unknown	Unknown	Unknown
YPR114W_p	YPR114W	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0179174197568093	0.299423464644934	999	Putative protein of unknown function	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YKR039W	GAP1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PLASMA MEMBRANE	0.0178406753685038	0.301498498039649	1000	General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth	amino acid transport|gamma-aminobutyric acid transport|ammonia assimilation cycle|polyamine transport	amino acid transmembrane transporter activity|polyamine transmembrane transporter activity|L-proline transmembrane transporter activity	endosome|fungal-type vacuole lumen|integral to membrane|plasma membrane|ER to Golgi transport vesicle|integral to plasma membrane|multivesicular body
YER022W	SRB4	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0178336198779179	0.301689745322654	1001	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination	transcription initiation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	activating transcription factor binding|structural molecule activity|core RNA polymerase II recruiting transcription factor activity	core mediator complex
YKL186C	MTR2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0178212520039939	0.302025185668569	1002	mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA	poly(A)+ mRNA export from nucleus|ribosomal large subunit export from nucleus	protein binding	integral to membrane|nuclear RNA export factor complex|nuclear pore
YMR074C	YMR074C	hom	FT	NUCLEUS	0.0178138973676799	0.302224775027261	1003	Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress	apoptotic process	molecular_function	nucleus|cytoplasm
YOR360C	PDE2	hom	FT	SIGNALING|NUCLEUS	0.0177768617844713	0.303231175645855	1004	High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon	cAMP-mediated signaling	3',5'-cyclic-AMP phosphodiesterase activity	nucleus|cytoplasm
YGR238C	KEL2	hom	FT	CELL CYCLE|SITE OF POLARIZED GROWTH	0.01774345162351	0.304140967685541	1005	Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate	conjugation with cellular fusion|negative regulation of exit from mitosis	molecular_function	mating projection tip|cellular bud neck|cellular bud tip
YDR508C	GNP1	hom	FT	MITOCHONDRION|PLASMA MEMBRANE	0.0177194364570837	0.304796042868358	1006	High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity|L-proline transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YER041W	YEN1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.017686057702694	0.305708087414627	1007	Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p	DNA repair|response to DNA damage stimulus	single-stranded DNA specific endodeoxyribonuclease activity|crossover junction endodeoxyribonuclease activity	nucleus|cytoplasm
YHL003C	LAG1	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0176684831513116	0.30647766260144	1008	Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress	replicative cell aging|ceramide biosynthetic process	sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YNL199C	GCR2	hom	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM|NUCLEUS	0.0176639797271565	0.306312341253855	1009	Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p	positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity	nuclear envelope|nucleus
YHR143W-A	RPC10	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0176586607946738	0.306458033717869	1010	RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress	transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YKL179C	COY1	hom	FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0176536371495581	0.306595680017786	1011	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function	Golgi vesicle transport	molecular_function	Golgi membrane
YHL038C	CBP2	hom	FT	RNA PROCESSING|MITOCHONDRION	0.0176536145425673	0.306596299534765	1012	Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene	Group I intron splicing	RNA binding	mitochondrion
YLR371W	ROM2	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|SITE OF POLARIZED GROWTH	0.017603071165977	0.30798345203447	1013	GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p	regulation of fungal-type cell wall organization|positive regulation of endocytosis|establishment of cell polarity|small GTPase mediated signal transduction|negative regulation of cAMP-mediated signaling|activation of Rho GTPase activity	phosphatidylinositol-4,5-bisphosphate binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity	incipient cellular bud site|mating projection tip|cellular bud tip
YIL069C	RPS24B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS|RIBOSOME	0.0175783029929675	0.308736864781868	1014	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YDL199C_p	YDL199C	hom			0.0175521036353958	0.309602945897367	1015	Putative transporter, member of the sugar porter family	transport|transmembrane transport	substrate-specific transmembrane transporter activity	integral to membrane|membrane
YDR245W	MNN10	hom	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0175482615023101	0.309708881186473	1016	Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family	N-glycan processing|cell wall mannoprotein biosynthetic process|substituted mannan metabolic process|barrier septum assembly	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YBR027C_d	YBR027C	hom			0.0175479664198592	0.309500512711405	1017	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR260C	TIF11	het	FT	TRANSLATION|RIBOSOME	0.0174992483183533	0.310845849238569	1018	Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3	translational initiation	double-stranded RNA binding|translation initiation factor activity	ribosome
YLR264W	RPS28B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME	0.0174928414071624	0.311023060804057	1019	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YOR380W	RDR1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0174817054172276	0.311692224875736	1020	Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins	response to xenobiotic stimulus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YMR129W	POM152	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|NUCLEAR PORE	0.0174594210829489	0.311948528115708	1021	Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210	nucleocytoplasmic transport|nuclear pore organization|protein import into nucleus|spindle pole body duplication associated with nuclear envelope	protein anchor|structural constituent of nuclear pore	mitochondrion|integral to membrane|nuclear pore transmembrane ring|nuclear envelope lumen|nuclear pore
YGR004W	PEX31	hom	FT	PEROXISOME ORGANIZATION	0.017458626204084	0.31197056176978	1022	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p	peroxisome organization	molecular_function	integral to membrane|integral to peroxisomal membrane
YBL015W	ACH1	hom	FT	KETONE METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.0174508944896683	0.312184934607747	1023	Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth	acetate metabolic process	acetate CoA-transferase activity|acetyl-CoA hydrolase activity	cytosol|mitochondrion
YBL056W	PTC3	hom	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0174452697401808	0.312340949785436	1024	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication	inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YGR248W	SOL4	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0174420508935311	0.312502413051012	1025	6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	6-phosphogluconolactonase activity	cytosol|nucleus|cytoplasm
YLR373C	VID22	hom	FT	PROTEIN LOCALIZATION|NUCLEUS|PLASMA MEMBRANE	0.0174171501397303	0.313121680545041	1026	Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles	vacuolar protein catabolic process	molecular_function	integral to plasma membrane
YJR096W	YJR096W	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0174081905934833	0.313370708730621	1027	Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity	nucleus|cytoplasm
YKR065C	PAM17	hom	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0174067216553678	0.313700323404891	1028	Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress	protein import into mitochondrial matrix	molecular_function	mitochondrion|presequence translocase-associated import motor
YNR035C	ARC35	het	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0174055930880052	0.313803951594152	1029	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin	mitochondrion inheritance|receptor-mediated endocytosis|microtubule cytoskeleton organization|actin cytoskeleton organization	structural molecule activity	cytosol|Arp2/3 protein complex
YOR122C	PFY1	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE|CYTOSKELETON	0.0173769567458805	0.31423986378396	1030	Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress	positive regulation of formin-nucleated actin cable assembly|sequestering of actin monomers|intracellular transport	actin monomer binding|phosphatidylinositol-4,5-bisphosphate binding|proline-rich region binding	cytosol|extrinsic to plasma membrane
YLR222C	UTP13	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.017367764108628	0.314495972015718	1031	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YPR142C_d	YPR142C	het			0.01730014763505	0.316383991186926	1032	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing	Unknown	Unknown	Unknown
YPL262W	FUM1	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0172677738375147	0.318085579777287	1033	Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria	fumarate metabolic process|tricarboxylic acid cycle	fumarate hydratase activity	cytosol|mitochondrion|mitochondrial matrix
YBR069C	TAT1	hom	FF|FT	PLASMA MEMBRANE	0.0172672109505833	0.318391098506822	1034	Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress	amino acid transport|tyrosine transport|tryptophan transport|transmembrane transport	amino acid transmembrane transporter activity|low-affinity tryptophan transmembrane transporter activity	integral to membrane|plasma membrane
YNR064C	YNR064C	hom			0.0172547580758273	0.317655542075358	1035	Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides	response to toxin	epoxide hydrolase activity	cellular_component
YGR216C	GPI1	het	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM	0.0172386678030464	0.318107100440359	1036	Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs	GPI anchor biosynthetic process	phosphatidylinositol N-acetylglucosaminyltransferase activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane
YCR002C	CDC10	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0172385834254683	0.318109469525135	1037	Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress	sporulation|maintenance of cell polarity|exit from mitosis|cell cycle cytokinesis|septin ring assembly	protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding	spindle microtubule|ascospore-type prospore|septin complex|prospore membrane|mating projection base|meiotic spindle|septin filament array|cellular bud neck septin ring|mating projection tip
YKL202W_d	YKL202W	hom			0.0172345854414786	0.318221734900539	1038	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL060W_p	YIL060W	hom			0.0171999493976334	0.319195418022807	1039	Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene	biological_process	molecular_function	cellular_component
YOR013W_d	IRC11	hom			0.0171774927126648	0.320044311803432	1040	Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci	Unknown	Unknown	Unknown
YPR152C	URN1	hom	FT	RNA PROCESSING|NUCLEUS	0.0171657075611908	0.32015993301665	1041	Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase	biological_process	molecular_function	nucleus
YGR185C	TYS1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEUS	0.0171439653606757	0.320989898424456	1042	Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress	tyrosyl-tRNA aminoacylation	tyrosine-tRNA ligase activity	nucleus|cytoplasm
YJL102W	MEF2	hom	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION	0.0171353709105654	0.32101603741164	1043	Mitochondrial elongation factor involved in translational elongation	translational elongation	translation elongation factor activity	mitochondrion
YHR097C_p	YHR097C	hom	FT	NUCLEUS	0.0171067155977897	0.321826065835075	1044	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YKR106W	GEX2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0170983855874554	0.322061788555232	1045	Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway	glutathione transmembrane transport	solute:hydrogen antiporter activity	integral to membrane|plasma membrane|vacuolar membrane
YGL246C	RAI1	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0170803112061549	0.323658237507341	1046	Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z	deadenylation-dependent decapping of nuclear-transcribed mRNA|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|termination of RNA polymerase II transcription, poly(A)-coupled|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	enzyme regulator activity|m7G(5')pppN diphosphatase activity	nucleus
YOR078W	BUD21	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0170771129152826	0.322664273792412	1047	Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|90S preribosome
YJL105W	SET4	hom	FT	CHROMATIN ORGANIZATION	0.0170635184456769	0.323121836575259	1048	Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLL060C	GTT2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0170470565239268	0.323516783484753	1049	Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress	glutathione metabolic process	glutathione transferase activity	mitochondrion
YLR205C	HMX1	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0170331942968258	0.324126980799713	1050	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants	response to oxidative stress|cellular iron ion homeostasis|heme catabolic process	heme oxygenase (decyclizing) activity	endoplasmic reticulum|membrane|nuclear outer membrane
YDR463W	STP1	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS|PLASMA MEMBRANE	0.017020612111311	0.324629021208997	1051	Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication	positive regulation of transcription, DNA-dependent|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	plasma membrane|nucleus|cytoplasm
YMR145C	NDE1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.016947155531367	0.326360875364724	1052	Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain	glucose catabolic process to ethanol|NADH oxidation|chronological cell aging	NADH dehydrogenase activity	mitochondrion
YPL228W	CET1	het	FT	RNA PROCESSING|NUCLEUS	0.0169318229830398	0.32679881254878	1053	Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide	7-methylguanosine mRNA capping	polynucleotide 5'-phosphatase activity	mRNA cap methyltransferase complex|nucleus
YGR270W	YTA7	hom	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0168632224606297	0.328762890809351	1054	Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p	negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter	chromatin binding|histone binding	extrinsic to endoplasmic reticulum membrane|nucleus
YEL052W	AFG1	hom	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|RESPONSE TO OXIDATIVE STRESS|PEROXISOME ORGANIZATION|MITOCHONDRION	0.0168595494042374	0.32886826813999	1055	Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain	protein import into peroxisome matrix|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process	molecular_function	mitochondrion|mitochondrial inner membrane
YMR182C	RGM1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|CHROMOSOME	0.0168588752171401	0.328887612456933	1056	Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nuclear chromatin
YBL028C	YBL028C	hom	FT	NUCLEUS	0.0168447287120289	0.329293685355743	1057	Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YNL227C	JJJ1	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION|RIBOSOME	0.0168400226443247	0.329428844136018	1058	Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis	ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|endocytosis|regulation of cell size|rRNA processing	ATPase activator activity	cytosol|mitochondrion|cytosolic large ribosomal subunit|nucleolus|cytoplasm
YLR138W	NHA1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0168371660368167	0.329510903735798	1059	Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH	cellular potassium ion homeostasis|cellular monovalent inorganic cation homeostasis|response to osmotic stress	cation:cation antiporter activity|sodium:hydrogen antiporter activity	membrane raft|integral to membrane|plasma membrane
YJL019W	MPS3	het	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON	0.0168259528026215	0.32990526342172	1060	Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p	meiotic telomere clustering|synapsis|nuclear migration involved in conjugation with cellular fusion|spindle pole body duplication associated with nuclear envelope|telomere tethering at nuclear periphery|mitotic sister chromatid cohesion	molecular_function	nuclear envelope|nuclear periphery|integral to membrane|nuclear chromosome, telomeric region|half bridge of spindle pole body
YJR137C	MET5	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS	0.0168224343940113	0.330295092822195	1061	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine	fungal-type cell wall organization|sulfate assimilation	sulfite reductase (NADPH) activity	sulfite reductase complex (NADPH)|cytoplasm
YJL122W	ALB1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0167640729557889	0.331615094733339	1062	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p	ribosomal large subunit biogenesis	molecular_function	ribosome|nucleus|cytoplasm
YPR069C	SPE3	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.0167581094108499	0.33178715449029	1063	Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells	spermidine biosynthetic process|pantothenate biosynthetic process	spermidine synthase activity	nucleus|cytoplasm
YOR150W	MRPL23	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0167564803337032	0.331834166531254	1064	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDR122W	KIN1	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION|PLASMA MEMBRANE	0.016742213950154	0.332246050832289	1065	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p	protein autophosphorylation|exocytosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	internal side of plasma membrane|plasma membrane
YHR143W	DSE2	hom	FF|FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION	0.0167067050934012	0.333272658684804	1066	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP	cytokinesis, completion of separation|pseudohyphal growth	glucosidase activity	extracellular region|fungal-type cell wall
YGR169C-A_p	YGR169C-A	hom			0.0166989865069696	0.333496083649638	1067	Putative protein of unknown function; YGR169C-A has a paralog, YJR005C-A, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YOR100C	CRC1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|MITOCHONDRION	0.0166913250156673	0.333717951427562	1068	Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation	fatty acid metabolic process	carnitine:acyl carnitine antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YBR037C	SCO1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.0166870047101634	0.333843104350517	1069	Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication	copper ion transport|response to redox state|protein complex assembly	copper ion binding|thioredoxin peroxidase activity	mitochondrion|mitochondrial inner membrane
YER126C	NSA2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0166740104906297	0.334219710210132	1070	Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleus|preribosome, large subunit precursor
YHL013C	OTU2	hom			0.0166674064541581	0.334411217046796	1071	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|cytoplasm
YDR457W	TOM1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|PROTEOLYSIS|RNA LOCALIZATION|NUCLEUS	0.0166647773446893	0.334487476825694	1072	E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mitosis|nucleocytoplasmic transport|nucleus organization|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell size|protein ubiquitination	ubiquitin-protein ligase activity	integral to membrane|nucleolus|nucleus
YJL104W	PAM16	het	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0165808275896288	0.336928407685955	1073	Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain	protein import into mitochondrial matrix	protein domain specific binding	mitochondrion|presequence translocase-associated import motor|mitochondrial inner membrane presequence translocase complex
YBL048W_d	RRT1	hom			0.016577705806159	0.337091445665298	1074	Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR054W	SMK1	hom	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION|MITOCHONDRION	0.0165654864547244	0.337375702082488	1075	Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p	ascospore wall assembly|protein phosphorylation|negative regulation of sporulation resulting in formation of a cellular spore	MAP kinase activity	mitochondrion
YGR150C	CCM1	hom	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0165498721906413	0.338336056336076	1076	Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport	rRNA metabolic process|mitochondrial RNA processing|mitochondrial genome maintenance	rRNA binding	mitochondrion
YDR246W	TRS23	het	FT	VESICLE-MEDIATED TRANSPORT|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0165399805973721	0.338120208543668	1077	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4	chromosome organization|ER to Golgi vesicle-mediated transport	Rab guanyl-nucleotide exchange factor activity	TRAPP complex
YDR420W	HKR1	hom	FT	CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.016525740687802	0.338752476653687	1078	Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection	(1->3)-beta-D-glucan biosynthetic process|fungal-type cell wall organization|osmosensory signaling pathway via Sho1 osmosensor|hyperosmotic response|cellular bud site selection	osmosensor activity	site of polarized growth|plasma membrane
YLR230W_d	YLR230W	het			0.0165117041075456	0.338946820494895	1079	Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity	Unknown	Unknown	Unknown
YOR157C	PUP1	het	FF|FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0165089917397474	0.339747344827622	1080	Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	endopeptidase activity	proteasome storage granule|nucleus|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YDR184C	ATC1	hom	FT	CELL CYCLE|CELL DIVISION|NUCLEUS	0.0164973232598107	0.339367715333194	1081	Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress	bipolar cellular bud site selection|response to stress	molecular_function	nucleus
YPR019W	MCM4	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0164321077360169	0.341280629110258	1082	Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p	S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|DNA unwinding involved in replication|double-strand break repair via break-induced replication|DNA replication initiation|pre-replicative complex assembly	four-way junction helicase activity|DNA helicase activity|DNA replication origin binding|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding|ATP-dependent 3'-5' DNA helicase activity	replication fork protection complex|nuclear replication fork|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YBR064W_d	YBR064W	hom			0.016430591110289	0.341325196992164	1083	Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C	Unknown	Unknown	Unknown
YLR067C	PET309	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0164296249804034	0.341353589829399	1084	Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)	positive regulation of mitochondrial translational initiation|RNA metabolic process|mitochondrial respiratory chain complex IV biogenesis|aerobic respiration	translation regulator activity	extrinsic to mitochondrial inner membrane|mitochondrion|integral to membrane|mitochondrial inner membrane
YGR147C	NAT2	het	FT	MITOCHONDRION	0.0164192415826448	0.341658834795105	1085	Protein with an apparent role in acetylation of N-terminal methionine residues	N-terminal peptidyl-methionine acetylation	molecular_function	mitochondrion
YPL271W	ATP15	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION	0.0164135836180477	0.343051781363529	1086	Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YLR149C	YLR149C	hom			0.0164051570532645	0.342073162373805	1087	Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cellular_component
YIR001C	SGN1	hom			0.0163665422165991	0.343210750133498	1088	Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation	mRNA metabolic process	poly(A) RNA binding	cytoplasm
YPL137C	GIP3	hom	FT	CHROMOSOME SEGREGATION|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.016352002704044	0.343639707553687	1089	Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication	chromosome segregation|regulation of phosphoprotein phosphatase activity	protein phosphatase type 1 regulator activity|protein phosphatase 1 binding	mitochondrion|ribosome|endoplasmic reticulum|cytoplasm
YDR322W	MRPL35	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0163084158379625	0.347094714559685	1090	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YLR346C_p	YLR346C	hom	FT	MITOCHONDRION	0.0163027005614292	0.345168744640553	1091	Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene	biological_process	molecular_function	mitochondrion
YDR160W	SSY1	het	FT	PLASMA MEMBRANE	0.0162995587840757	0.345189795974785	1092	Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes	response to amino acid stimulus	molecular_function	integral to membrane|plasma membrane
YEL046C	GLY1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0162605585158197	0.346561219848699	1093	Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis	threonine catabolic process|glycine biosynthetic process	threonine aldolase activity|L-allo-threonine aldolase activity	cytosol
YML111W	BUL2	hom	FT	UBIQUITIN LIGASE COMPLEX	0.0162387241745469	0.346993462202088	1094	Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication	protein polyubiquitination|protein monoubiquitination	ubiquitin-ubiquitin ligase activity	ubiquitin ligase complex|cytoplasm
YLR421C	RPN13	hom	FT	PROTEOLYSIS|NUCLEUS	0.01622735154996	0.347331309560102	1095	Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress	ubiquitin-dependent protein catabolic process	ubiquitin binding	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YOR261C	RPN8	het	FT	PROTEOLYSIS	0.0162162893652158	0.347660135288944	1096	Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p	ubiquitin-dependent protein catabolic process	molecular_function	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YJR076C	CDC11	het	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0162063493958495	0.348243441068922	1097	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells	maintenance of cell polarity|cell cycle cytokinesis|positive regulation of protein kinase activity	structural molecule activity|GTP binding|1-phosphatidylinositol binding	spindle microtubule|septin complex|prospore membrane|ascospore wall|mating projection base|meiotic spindle|cellular bud neck septin ring|septin filament array|cytoplasmic microtubule|mating projection tip
YGL234W	ADE5,7	hom	FT	NUCLEOTIDE METABOLISM	0.0162043081716569	0.348016501917211	1098	Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities	purine nucleobase metabolic process|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity	cytoplasm
YHR057C	CPR2	hom			0.0161875473202312	0.348515423266667	1099	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	cellular_component
YGR078C	PAC10	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS	0.0161650822227888	0.350120669392903	1100	Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding	tubulin complex assembly	tubulin binding	prefoldin complex|polysome|cytoplasm
YLR369W	SSQ1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM|MITOCHONDRION	0.0161648485317897	0.349191823426882	1101	Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia	iron-sulfur cluster assembly|intracellular sequestering of iron ion|protein maturation	unfolded protein binding	mitochondrion|mitochondrial matrix
YDR337W	MRPS28	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0161431351095262	0.349911492552457	1102	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome|RNA binding	mitochondrion|mitochondrial small ribosomal subunit
YKL201C	MNN4	hom	FT	CARBOHYDRATE METABOLISM	0.016134741045562	0.350090279666884	1103	Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication	protein O-linked glycosylation|protein N-linked glycosylation|response to stress	molecular_function	membrane
YKL028W	TFA1	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION|RNA POL II, HOLOENZYME	0.0161208436256418	0.350505495285849	1104	TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening	transcriptional open complex formation at RNA polymerase II promoter|transcription from RNA polymerase II promoter	single-stranded DNA binding|TFIIH-class transcription factor binding|RNA polymerase II core binding	mitochondrion|transcription factor TFIIE complex
YLR375W	STP3	hom	FT	NUCLEUS	0.0161046696778297	0.350989119987888	1105	Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids	biological_process	sequence-specific DNA binding	nucleus
YBL007C	SLA1	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON	0.0160627358255009	0.353252074221496	1106	Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains	fungal-type cell wall organization|endocytosis|actin cortical patch assembly	ubiquitin binding|protein binding, bridging	cell cortex|nucleus|mating projection tip|actin cortical patch
YOR094W	ARF3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH	0.0160393475503832	0.352946646080048	1107	Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity	intracellular protein transport|positive regulation of phosphatidylinositol biosynthetic process|endocytosis|actin filament bundle assembly|actin cortical patch localization|cellular bud site selection	mRNA binding|GTPase activity	cellular bud neck|cellular bud tip
YNR009W	NRM1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS	0.0159804463064902	0.354717662130428	1108	Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase	negative regulation of transcription involved in G1 phase of mitotic cell cycle	repressing transcription factor binding|transcription factor binding transcription factor activity	MBF transcription complex|nucleus|cytoplasm
YBR220C_p	YBR220C	hom			0.0159647341090034	0.35526277966756	1109	Putative protein of unknown function; YBR220C is not an essential gene	biological_process	molecular_function	integral to membrane
YOR263C_d	YOR263C	hom			0.0159540865325044	0.355512049325175	1110	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W	Unknown	Unknown	Unknown
YPR155C	NCA2	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0159506813361243	0.35561475125008	1111	Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p	mRNA metabolic process|aerobic respiration	molecular_function	mitochondrial outer membrane|mitochondrion
YFR050C	PRE4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.015942416755523	0.356079340009155	1112	Beta 7 subunit of the 20S proteasome	proteasome assembly|proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YGR120C	COG2	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0159409279738255	0.355909019612844	1113	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	peroxisome degradation|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|retrograde transport, vesicle recycling within Golgi|CVT pathway	molecular_function	Golgi transport complex|extrinsic to membrane
YDR433W_d	YDR433W	hom			0.0159394600810888	0.355953320639328	1114	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR499W	LCD1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0159313762277012	0.356197353736164	1115	Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress	establishment of protein localization|telomere maintenance via telomerase|DNA damage checkpoint	damaged DNA binding	nuclear chromosome
YFL010C	WWM1	hom	FT	NUCLEUS|MITOCHONDRION	0.0159195411890383	0.357992871576528	1116	WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1	biological_process	molecular_function	mitochondrion|nucleus|cytoplasm
YJL149W	DAS1	hom	FT	PROTEOLYSIS|UBIQUITIN LIGASE COMPLEX	0.0159119768791449	0.356783405757636	1117	Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YGR025W_d	YGR025W	hom			0.0159074746229459	0.357134682701302	1118	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR439W	MRPL4	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0158773317636856	0.357831540163272	1119	Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOR247W	SRL1	hom	FT	CELL WALL ORG/BIOGENESIS|SITE OF POLARIZED GROWTH	0.0158719973396887	0.357993096824924	1120	Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication	fungal-type cell wall organization|nucleobase-containing compound metabolic process	molecular_function	fungal-type cell wall|fungal-type vacuole|cytoplasm|cellular bud tip
YPR082C	DIB1	het	FT	CELL CYCLE|RNA PROCESSING|CELL DIVISION|NUCLEUS	0.0158703623352609	0.358042623230969	1121	17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein	mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex|U5 snRNP
YNR069C	BSC5	hom			0.0158463343605674	0.358842622073078	1122	Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro	biological_process	molecular_function	cellular_component
YKL220C	FRE2	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|PLASMA MEMBRANE	0.0158257608811451	0.359395320961136	1123	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YDR026C	NSI1	hom	FT	CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0157795564469466	0.360871629208504	1124	RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication	termination of RNA polymerase I transcription|chromatin silencing at rDNA|Unknown	DNA binding	ribosome|nucleolus|rDNA heterochromatin
YJL157C	FAR1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEUS|SITE OF POLARIZED GROWTH	0.0157632572495319	0.361296358539107	1125	Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress	maintenance of protein location in nucleus|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell cycle arrest in response to pheromone	cyclin-dependent protein kinase inhibitor activity	nucleus|mating projection tip|membrane|cytoplasm
YKL079W	SMY1	hom	FT	VESICLE-MEDIATED TRANSPORT|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0157594135160164	0.361413470407158	1126	Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins	exocytosis	motor activity	incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YPL274W	SAM3	hom	FT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.0157299646532556	0.362311515188975	1127	High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p	spermidine transport|putrescine transport|S-adenosylmethionine transport	S-adenosylmethionine transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity	integral to membrane|plasma membrane
YNL256W	FOL1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.0157080047664559	0.362982091776104	1128	Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities	tetrahydrofolate biosynthetic process	dihydroneopterin aldolase activity|2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity|dihydropteroate synthase activity	mitochondrial envelope|mitochondrion|cytoplasm
YER044C	ERG28	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0157060032511734	0.363043249501149	1129	Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p	ergosterol biosynthetic process	protein binding, bridging	endoplasmic reticulum membrane
YMR273C	ZDS1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL WALL ORG/BIOGENESIS|RNA LOCALIZATION|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|SITE OF POLARIZED GROWTH|NUCLEAR PORE	0.0156988011256536	0.363263368906472	1130	Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication	mRNA export from nucleus|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|chromatin silencing|establishment of cell polarity|regulation of protein localization|cell aging	protein phosphatase type 2A regulator activity	incipient cellular bud site|nuclear pore|cellular bud neck|cellular bud tip|cytoplasm
YOL147C	PEX11	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|PEROXISOME ORGANIZATION|ENDOPLASMIC RETICULUM	0.0156926748757188	0.363808604169186	1131	Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p	peroxisome fission|fatty acid oxidation	molecular_function	endoplasmic reticulum|peroxisomal membrane
YER099C	PRS2	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM	0.0156820082411599	0.364349793339685	1132	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YIL046W-A_p	YIL046W-A	hom			0.0156726604477941	0.364063010661881	1133	Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YOR235W_d	IRC13	hom			0.0156711211137681	0.36411013306869	1134	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci	Unknown	Unknown	Unknown
YDL074C	BRE1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0156591574250841	0.364476497862811	1135	E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control	mitotic cell cycle G1/S transition DNA damage checkpoint|intra-S DNA damage checkpoint|meiotic DNA double-strand break formation|histone monoubiquitination|double-strand break repair via homologous recombination|transcription from RNA polymerase II promoter|chromatin silencing at telomere	ubiquitin-protein ligase activity	nuclear chromatin
YKL084W	HOT13	hom	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0156498638233463	0.36476125528151	1136	Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc	protein import into mitochondrial intermembrane space	zinc ion binding	mitochondrial intermembrane space
YEL008W_d	YEL008W	hom			0.0156373189249324	0.365431980524502	1137	Hypothetical protein predicted to be involved in metabolism	Unknown	Unknown	Unknown
YIL097W	FYV10	hom	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS	0.0156332401426396	0.36555706770758	1138	Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis	ubiquitin-protein ligase activity	nucleus|GID complex|cytoplasm
YDL031W	DBP10	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0156258794704668	0.365496781348946	1139	Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus|preribosome, large subunit precursor
YIR037W	HYR1	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	0.015618844446183	0.36599876522087	1140	Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor	cellular response to oxidative stress	phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity	intracellular
YJL183W	MNN11	hom	FT	CARBOHYDRATE METABOLISM|GOLGI APPARATUS	0.0156059012513855	0.366324645531903	1141	Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p	protein glycosylation	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YDR460W	TFB3	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME	0.0155937675672168	0.366554468603816	1142	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	holo TFIIH complex|TFIIK complex
YLR452C	SST2	hom	FT	SIGNALING|PLASMA MEMBRANE	0.0155881980401462	0.366654222238589	1143	GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|signal transduction	GTPase activator activity	plasma membrane
YPL092W	SSU1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0155588162518996	0.367987219140058	1144	Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein	sulfite transport	sulfite transmembrane transporter activity	integral to membrane|plasma membrane
YLL054C_p	YLL054C	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0155295453338866	0.368460366381099	1145	Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene	biological_process	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	cellular_component
YER174C	GRX4	hom	FT	ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0154960460433641	0.369494418217959	1146	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription is regulated by Yap5	cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization	disulfide oxidoreductase activity	nucleus
YDR047W	HEM12	het	FF|FT	COFACTOR METABOLISM|NUCLEUS	0.0154955871602963	0.369508595470173	1147	Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda	heme biosynthetic process	uroporphyrinogen decarboxylase activity	nucleus|cytoplasm
YLR386W	VAC14	hom	FT	PROTEIN LOCALIZATION|LIPID METABOLISM	0.0154722741067377	0.37022930003688	1148	Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p	phosphatidylinositol biosynthetic process|positive regulation of kinase activity	protein binding, bridging	fungal-type vacuole membrane|PAS complex|extrinsic to vacuolar membrane
YBR095C	RXT2	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0154718324714799	0.370599949731591	1149	Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth	conjugation with cellular fusion|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|invasive growth in response to glucose limitation	histone deacetylase activity	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YKL163W	PIR3	hom	FT	CELL WALL ORG/BIOGENESIS	0.0154694240005202	0.370317468644014	1150	O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall
YOR370C	MRS6	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|PROTEIN PRENYLATION	0.0154575542848447	0.370684800850322	1151	Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress	protein targeting to membrane|protein geranylgeranylation|ER to Golgi vesicle-mediated transport|activation of Rab GTPase activity	Rab geranylgeranyltransferase activity|Rab GTPase binding	Rab-protein geranylgeranyltransferase complex|membrane|cytoplasm
YKR012C_d	YKR012C	hom			0.0154403284322433	0.371218291517284	1152	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2	Unknown	Unknown	Unknown
YEL041W	YEF1	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.0154278481061269	0.371605108914285	1153	ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication	NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	cellular_component
YER002W	NOP16	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0154248129169071	0.371770535795876	1154	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis	ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YAL046C	AIM1	hom			0.0154152868745964	0.372065993145329	1155	Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YKL074C	MUD2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0153950715324755	0.372622181093321	1156	Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65	mRNA branch site recognition	pre-mRNA branch point binding	commitment complex
YOL164W-A_p	YOL164W-A	hom			0.0153689303474302	0.373505851507279	1157	Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YML009C-A_d	YML009C-A	hom			0.0153104377023473	0.375256370581318	1158	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER176W	ECM32	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	0.0152931326822037	0.375796394192681	1159	DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes	regulation of translational termination	RNA helicase activity|DNA helicase activity	polysome
YER143W	DDI1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|PLASMA MEMBRANE	0.0152692511221988	0.376542433750766	1160	DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains	vesicle-mediated transport|protein secretion|ubiquitin-dependent protein catabolic process	ubiquitin binding|SNARE binding|aspartic-type endopeptidase activity	plasma membrane
YGR259C_d	YGR259C	hom			0.015252553703241	0.37727808698548	1161	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W	Unknown	Unknown	Unknown
YJL091C	GWT1	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0152408052592016	0.378144449590295	1162	Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors	GPI anchor biosynthetic process	glucosaminyl-phosphotidylinositol O-acyltransferase activity	integral to membrane|nuclear outer membrane-endoplasmic reticulum membrane network
YDL083C	RPS16B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.015234889857354	0.377973284761394	1163	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YGR230W	BNS1	hom	FT	CELL CYCLE	0.0152041412480711	0.378581045843113	1164	Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis	meiosis	molecular_function	cellular_component
YMR059W	SEN15	het	FT	RNA PROCESSING|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	0.0151871985529909	0.379112638867463	1165	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p	tRNA-type intron splice site recognition and cleavage	tRNA-intron endonuclease activity	tRNA-intron endonuclease complex
YJL185C	ATG36	hom			0.0151673918092394	0.379734675810455	1166	Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene	peroxisome degradation	molecular_function	peroxisome
YLL046C	RNP1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	0.0151635731419285	0.380210130733108	1167	Ribonucleoprotein that contains two RNA recognition motifs (RRM)	ribosome biogenesis	RNA binding	cytoplasm
YDR298C	ATP5	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION	0.0151574444897229	0.380047310943722	1168	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, stator stalk|mitochondrial proton-transporting ATP synthase complex
YDR541C_p	YDR541C	hom	FT	OXIDATION-REDUCTION PROCESS	0.0151260926926513	0.381033703366756	1169	Putative dihydrokaempferol 4-reductase	biological_process	carbonyl reductase (NADPH) activity	cellular_component
YPR026W	ATH1	hom	FT	CARBOHYDRATE METABOLISM	0.015115411594017	0.381370111331706	1170	Acid trehalase required for utilization of extracellular trehalose	trehalose catabolic process|response to stress	alpha,alpha-trehalase activity	fungal-type cell wall|cell wall-bounded periplasmic space|fungal-type vacuole
YAR008W	SEN34	het	FT	RNA PROCESSING|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	0.01508955144889	0.382185347272539	1171	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease	tRNA-type intron splice site recognition and cleavage	tRNA-intron endonuclease activity	mitochondrial outer membrane|mitochondrion|tRNA-intron endonuclease complex
YOR008C-A_p	YOR008C-A	hom			0.0150880826497958	0.382444652566566	1172	Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres	biological_process	molecular_function	cellular_component
YKL037W	AIM26	hom	FF|FT	MITOCHONDRION	0.0150737563744451	0.382683808907263	1173	Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT	mitochondrion degradation	molecular_function	mitochondrion|integral to membrane
YDL027C_p	YDL027C	hom	FT	MITOCHONDRION	0.015044961695164	0.383593536851399	1174	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene	biological_process	molecular_function	mitochondrion
YPL165C	SET6	hom			0.0150418703783077	0.383691281329429	1175	SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability	biological_process	molecular_function	cellular_component
YOR350C	MNE1	hom	FT	RNA PROCESSING|MITOCHONDRION	0.0150352802701409	0.383899705109622	1176	Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA	Group I intron splicing	molecular_function	mitochondrion|ribonucleoprotein complex|mitochondrial matrix
YOR269W	PAC1	hom	FT	CELL CYCLE|CELL DIVISION|NUCLEUS|CYTOSKELETON	0.0150075526389986	0.384777398855176	1177	Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly	nuclear migration along microtubule	microtubule plus-end binding	cytoplasmic microtubule|nucleus|cytoplasm
YGR022C_d	YGR022C	hom			0.01499098602642	0.385302385207149	1178	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W	Unknown	Unknown	Unknown
YIL046W	MET30	het	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0149849068801678	0.385565993055483	1179	F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus	response to cadmium ion|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA-dependent DNA replication initiation|M phase of mitotic cell cycle|response to arsenic-containing substance|G1/S transition of mitotic cell cycle|protein polyubiquitination|regulation of transcription involved in G1 phase of mitotic cell cycle|protein ubiquitination	ubiquitin binding	nuclear SCF ubiquitin ligase complex|SCF ubiquitin ligase complex|nucleus
YPL155C	KIP2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|MITOCHONDRION|CYTOSKELETON	0.0149698216715378	0.385973707541259	1180	Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle	nuclear migration along microtubule|mitotic anaphase B|negative regulation of microtubule depolymerization	microtubule motor activity	mitochondrion|kinesin complex|cytoplasmic microtubule
YBL012C_d	YBL012C	hom			0.014963380209115	0.386178169013832	1181	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL169C_d	YKL169C	hom			0.0149571803998902	0.387084064862453	1182	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38	Unknown	Unknown	Unknown
YOL057W	YOL057W	hom	FT	PROTEOLYSIS|NUCLEUS	0.0149386864751865	0.38703339555608	1183	Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers	proteolysis	dipeptidyl-peptidase activity	nucleus|cytoplasm
YDR526C_d	YDR526C	het	FF		0.0149259638149758	0.387579533487232	1184	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL224C	WHI4	hom			0.0149102620515638	0.387866736023717	1185	Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication	regulation of cell size	RNA binding	cytoplasm
YAR007C	RFA1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0149072763531183	0.388457497214401	1186	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination	establishment of protein localization|telomere maintenance via telomerase|telomere maintenance via recombination|nucleotide-excision repair|DNA repair|mitotic recombination|heteroduplex formation|DNA unwinding involved in replication|reciprocal meiotic recombination|DNA replication|double-strand break repair via homologous recombination|protein ubiquitination	double-stranded DNA binding|single-stranded DNA binding|sequence-specific DNA binding	condensed nuclear chromosome|chromosome, telomeric region|DNA replication factor A complex|cytoplasm
YGR271C-A	EFG1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0148979263470585	0.388259516868953	1187	Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus	G1 phase of mitotic cell cycle|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus
YKL045W	PRI2	het	FT	RESPONSE TO DNA DAMAGE|ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME	0.0148614055951301	0.389423792292948	1188	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair	lagging strand elongation|DNA replication, synthesis of RNA primer|DNA synthesis involved in DNA repair|DNA replication|DNA replication initiation	single-stranded DNA binding|DNA primase activity	nuclear envelope|alpha DNA polymerase:primase complex|nucleus
YKL187C	FAT3	hom	FT	MITOCHONDRION	0.0148594739923039	0.390051567440939	1189	Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|integral to membrane
YBR289W	SNF5	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|CHROMOSOME|RSC COMPLEX	0.0148561530727199	0.389591416279487	1190	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions	sucrose catabolic process|double-strand break repair via homologous recombination|chromatin remodeling|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding	SWI/SNF complex|nucleus
YLR261C_d	VPS63	hom	FF		0.0148528944964613	0.389695429417313	1191	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YML086C	ALO1	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.0148410898496936	0.390072372836478	1192	D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress	cellular response to oxidative stress|dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinono-1,4-lactone oxidase activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YNL324W_d	YNL324W	hom			0.0148390399459233	0.39013785248916	1193	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL091C	NBP35	het	FT	RNA PROCESSING|COFACTOR METABOLISM|NUCLEUS	0.014838662944422	0.390149895697299	1194	Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases	iron-sulfur cluster assembly|tRNA wobble uridine modification	4 iron, 4 sulfur cluster binding|ATPase activity|iron ion binding	mitochondrion|nucleus|cytoplasm
YLL039C	UBI4	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.014837215667918	0.390196130640833	1195	Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress	protein deubiquitination|ascospore formation|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress	ATP-dependent protein binding|protein tag	cytoplasm
YMR310C_p	YMR310C	hom	FT	NUCLEUS	0.0147930598589464	0.391608339354657	1196	Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleus
YOL133W	HRT1	het	FT	CELL CYCLE|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0147753743587234	0.392174832602444	1197	RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF	G2/M transition of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle	ubiquitin-protein ligase activity	SCF ubiquitin ligase complex|nucleus|cytoplasm
YLL057C	JLP1	hom	FT	OXIDATION-REDUCTION PROCESS	0.0147110036880627	0.39424091359371	1198	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation	sulfur compound catabolic process	sulfonate dioxygenase activity	cellular_component
YMR140W	SIP5	hom	FT	RESPONSE TO NUTRIENT LEVELS	0.0147083554800152	0.39432605288117	1199	Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress	cellular response to glucose starvation	molecular_function	cytoplasm
YJL062W-A	COA3	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0146871535539864	0.395008090813561	1200	Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly	mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation	molecular_function	mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YGR034W	RPL26B	hom	FT	TRANSLATION|RIBOSOME	0.0146745287013751	0.395414554067898	1201	Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YEL005C	VAB2	hom			0.0146501202785328	0.396201111161227	1202	Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter	biological_process	molecular_function	cytoplasm
YJR098C_p	YJR098C	hom	FT	LIPID METABOLISM|MITOCHONDRION	0.0146475326318388	0.396284552942105	1203	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YMR218C	TRS130	het	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|GOLGI APPARATUS	0.0146280155704507	0.397266438836142	1204	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy	regulation of Rab GTPase activity|early endosome to Golgi transport|intra-Golgi vesicle-mediated transport	Rab guanyl-nucleotide exchange factor activity	TRAPP complex|trans-Golgi network|early endosome
YGL227W	VID30	hom	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS	0.0146232060633892	0.397139906786035	1205	Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm	regulation of nitrogen utilization|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process	molecular_function	nucleus|GID complex|cytoplasm
YBR157C	ICS2	hom			0.014606796463579	0.397599536832567	1206	Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization	biological_process	molecular_function	cellular_component
YGR202C	PCT1	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS	0.0145599282131022	0.399326695934237	1207	Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity	phosphatidylcholine biosynthetic process|CDP-choline pathway	choline-phosphate cytidylyltransferase activity	nuclear envelope|Golgi apparatus|nucleus
YGR169C	PUS6	hom	FT	RNA PROCESSING|MITOCHONDRION	0.0145296458287222	0.400097192345325	1208	tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|cytoplasm
YHR108W	GGA2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0145274720669189	0.400167701461523	1209	Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to vacuole transport|Golgi to endosome transport	ubiquitin binding|phosphatidylinositol-4-phosphate binding	trans-Golgi network
YLR111W_d	YLR111W	hom	FF		0.014515639309986	0.400551645009148	1210	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL032W	OPI10	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|NUCLEUS	0.01449483542925	0.401227215428908	1211	Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress	inositol metabolic process	molecular_function	nucleus|cytoplasm
YDR260C	SWM1	hom	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0144878575325842	0.401453963735822	1212	Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation	ascospore wall assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of mitotic metaphase/anaphase transition|protein ubiquitination	molecular_function	anaphase-promoting complex|nucleus
YHR019C	DED81	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.0144818047380155	0.40186136042139	1213	Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA	asparaginyl-tRNA aminoacylation	asparagine-tRNA ligase activity	cytosol
YLR396C	VPS33	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	0.0144775870267121	0.401787845940293	1214	ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole	regulation of SNARE complex assembly|endocytosis|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle fusion with vacuole|Golgi to vacuole transport|vacuole organization|vacuole fusion, non-autophagic|vesicle docking|protein targeting to vacuole	phosphatidylinositol binding|ATP binding	cytosol|fungal-type vacuole membrane|HOPS complex|fungal-type vacuole|CORVET complex
YBL018C	POP8	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0144494149656049	0.403055475068885	1215	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YCL052C	PBN1	het	FT	LIPID METABOLISM|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.014440270068201	0.403002378037223	1216	Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X	GPI anchor biosynthetic process|ER-associated protein catabolic process|protein processing	mannosyltransferase activity	endoplasmic reticulum
YDR067C_p	OCA6	hom			0.0144370290788919	0.403107964202038	1217	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT	biological_process	molecular_function	cytoplasm
YML074C	FPR3	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS	0.0144362360943919	0.403203932763626	1218	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p	meiotic recombination checkpoint	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	nucleolus
YOR203W_d	YOR203W	het			0.0144358475792498	0.403146459660488	1219	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation	Unknown	Unknown	Unknown
YMR144W_p	YMR144W	hom	FT	NUCLEUS	0.0144173874503655	0.403748210895814	1220	Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene	biological_process	molecular_function	nucleus
YPR014C_d	YPR014C	hom			0.0144026130648302	0.404230203697652	1221	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene	Unknown	Unknown	Unknown
YDR005C	MAF1	hom	FT	NUCLEUS	0.0143846846787481	0.404815553135284	1222	Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions	negative regulation of transcription from RNA polymerase III promoter	RNA polymerase III core binding	nucleolus|nucleus|cytoplasm
YLR131C	ACE2	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|NUCLEUS	0.0143759163285799	0.405733039346917	1223	Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication	Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YGR112W	SHY1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.014375136760496	0.405127492721688	1224	Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome	mitochondrial respiratory chain complex IV assembly|aerobic respiration	unfolded protein binding	mitochondrion|integral to membrane|mitochondrial inner membrane
YBR180W	DTR1	hom	FT	CELL WALL ORG/BIOGENESIS	0.0143604163925607	0.405608702473601	1225	Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation	ascospore wall assembly|amine transport|transmembrane transport	amine transmembrane transporter activity	integral to membrane|prospore membrane
YMR055C	BUB2	hom	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON	0.0143411867531366	0.406237834515545	1226	Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint	GTPase activator activity	spindle pole body
YKL097C_d	YKL097C	hom			0.0143366189372231	0.406457347781222	1227	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species	Unknown	Unknown	Unknown
YLR056W	ERG3	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0143131759408412	0.407155299525999	1228	C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase	ergosterol biosynthetic process	C-5 sterol desaturase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YPR099C_d	YPR099C	hom			0.0143021120015449	0.407867857190202	1229	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W	Unknown	Unknown	Unknown
YGL255W	ZRT1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0142961546513639	0.408063200933604	1230	High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor	high-affinity zinc ion transport	high affinity zinc uptake transmembrane transporter activity	integral to membrane|integral to plasma membrane
YML052W	SUR7	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|MITOCHONDRION|PLASMA MEMBRANE	0.0142468604493092	0.409332312353566	1231	Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants	endocytosis|ascospore formation	molecular_function	cell cortex|eisosome|mitochondrion|membrane raft|integral to membrane|plasma membrane|actin cortical patch
YJL131C	AIM23	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0142415687804269	0.409506325576442	1232	Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss	positive regulation of mitochondrial translational initiation	ribosome binding|translation initiation factor activity	mitochondrion
YNL332W	THI12	hom			0.0142298016832914	0.409963255113591	1233	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13	thiamine biosynthetic process	molecular_function	cellular_component
YDL123W	SNA4	hom			0.0142128331926516	0.410452045014929	1234	Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated	biological_process	molecular_function	fungal-type vacuole lumen|fungal-type vacuole membrane
YMR007W_d	YMR007W	hom			0.0141852309106007	0.411361686329875	1235	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR060C	ARO7	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.014177030739094	0.411632155645786	1236	Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis	aromatic amino acid family biosynthetic process	chorismate mutase activity	nucleus|cytoplasm
YJR067C	YAE1	het	FT	NUCLEUS	0.0141740300439803	0.411731155044361	1237	Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species	biological_process	molecular_function	nucleus|cytoplasm
YGL010W_p	YGL010W	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0141525387641384	0.412440611273734	1238	Putative protein of unknown function; YGL010W is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YBR118W	TEF2	hom	FT	TRANSLATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|CYTOSKELETON|RIBOSOME	0.0141222078110175	0.413443108630955	1239	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication	translational elongation|tRNA export from nucleus	GDP binding|GTP binding|translation elongation factor activity	ribosome|eukaryotic translation elongation factor 1 complex|cytoplasm
YNL061W	NOP2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0141072279667961	0.414287032307658	1240	Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles	rRNA processing	S-adenosylmethionine-dependent methyltransferase activity|RNA methyltransferase activity	nucleolus|preribosome, large subunit precursor
YDR462W	MRPL28	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0140988242180417	0.414216965695455	1241	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDR068W	DOS2	hom			0.0140890378730783	0.414541089244054	1242	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YKL148C	SDH1	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0140844759142031	0.414692232445919	1243	Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits	cellular respiration|mitochondrial electron transport, succinate to ubiquinone|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity|flavin adenine dinucleotide binding	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial membrane
YNL013C_d	YNL013C	hom			0.0140401162764351	0.416233127720587	1244	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W	Unknown	Unknown	Unknown
YBR251W	MRPS5	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0140315279577788	0.416448843401387	1245	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YJL013C	MAD3	hom	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS	0.0139772133853498	0.418255345339147	1246	Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover	distributive segregation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	mitotic checkpoint complex
YOR327C	SNC2	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0139745723982951	0.418343301952315	1247	Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication	endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion	SNAP receptor activity	SNARE complex|trans-Golgi network|endosome|transport vesicle membrane
YML083C	YML083C	hom			0.0139692608830156	0.418520231987339	1248	Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions	biological_process	molecular_function	cellular_component
YDL154W	MSH5	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0139490471829253	0.419193965976591	1249	Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans	reciprocal meiotic recombination	molecular_function	nucleus
YBR178W_d	YBR178W	hom			0.0139243267963703	0.420018776455184	1250	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C	Unknown	Unknown	Unknown
YMR034C_p	YMR034C	hom			0.0139187581815504	0.420204708075348	1251	Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene	biological_process	sterol transporter activity	integral to membrane
YBL069W	AST1	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|GOLGI APPARATUS|PLASMA MEMBRANE	0.0138927694189797	0.421073091089065	1252	Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication	protein targeting to membrane|protein transport into membrane raft	molecular_function	late endosome|membrane raft|Golgi apparatus|plasma membrane
YDL113C	ATG20	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.013889202993454	0.42119234096592	1253	Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate	mitochondrion degradation|early endosome to Golgi transport|macroautophagy|CVT pathway	phosphatidylinositol-3-phosphate binding	endosome|pre-autophagosomal structure|extrinsic to membrane
YBL100W-C_p	YBL100W-C	hom			0.0138837311101142	0.42172171485778	1254	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YIL150C	MCM10	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0138681052738738	0.421898186385879	1255	Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins	S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|double-strand break repair via break-induced replication|DNA replication initiation|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	double-stranded DNA binding|protein binding|DNA replication origin binding|single-stranded DNA binding	replication fork protection complex|replication fork|nucleus
YDL004W	ATP16	het	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION	0.0138631072265272	0.422065502590894	1256	Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YDR178W	SDH4	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0138620969530789	0.422306985408578	1257	Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain	mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion
YNR058W	BIO3	hom	FT	KETONE METABOLISM|COFACTOR METABOLISM	0.0137878338040718	0.424590077715258	1258	7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis	biotin biosynthetic process	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	cytoplasm
YDR373W	FRQ1	het	FT	SIGNALING|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE	0.0137842222315045	0.424711426648562	1259	N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily	regulation of signal transduction	enzyme activator activity|calcium ion binding	Golgi membrane
YPL056C_p	LCL1	hom	FT	PLASMA MEMBRANE	0.0137695128209579	0.425274908036054	1260	Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan	biological_process	molecular_function	cellular_component
YGR032W	GSC2	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PLASMA MEMBRANE|CYTOSKELETON	0.0137670614755915	0.425288305246843	1261	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)	ascospore wall assembly|(1->3)-beta-D-glucan biosynthetic process	1,3-beta-D-glucan synthase activity	1,3-beta-D-glucan synthase complex|integral to membrane|actin cap|prospore membrane
YLR144C	ACF2	hom	FT	CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	0.0137570349914634	0.425625568644738	1262	Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress	actin cytoskeleton organization	glucan endo-1,3-beta-D-glucosidase activity	intracellular
YPL208W	RKM1	hom	FT	NUCLEUS	0.0137554153162837	0.425749074487977	1263	SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)	peptidyl-lysine dimethylation	protein-lysine N-methyltransferase activity	nucleus|cytoplasm
YBR262C	AIM5	hom	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0136510076783324	0.429201575434228	1264	Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YPL097W	MSY1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0136478198232653	0.429309362546646	1265	Mitochondrial tyrosyl-tRNA synthetase	mitochondrial tyrosyl-tRNA aminoacylation	tyrosine-tRNA ligase activity	mitochondrion
YCL039W	GID7	hom	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS	0.0135949128717361	0.431375469691073	1266	Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process	molecular_function	nucleus|GID complex|cytoplasm
YDL018C	ERP3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0135769303821108	0.431710321911806	1267	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YLR259C	HSP60	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0135733412554282	0.431832088806608	1268	Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated	protein refolding|protein stabilization|chaperone-mediated protein complex assembly|'de novo' protein folding|protein maturation|protein import into mitochondrial intermembrane space	unfolded protein binding|DNA replication origin binding|single-stranded DNA binding|ATPase activity|chaperone binding	mitochondrial nucleoid|mitochondrion
YCL033C	MXR2	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.0135678636080914	0.432498906498026	1269	Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan	cellular response to oxidative stress	peptide-methionine (R)-S-oxide reductase activity	mitochondrion
YNL058C_p	YNL058C	hom			0.0135630231913333	0.432182256495917	1270	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene	biological_process	molecular_function	fungal-type vacuole
YMR203W	TOM40	het	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.0135501533245095	0.433031234909281	1271	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore	protein import into mitochondrial matrix	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YDR375C	BCS1	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0135354359580079	0.433187893930565	1272	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases	protein insertion into mitochondrial membrane from inner side|chaperone-mediated protein complex assembly|mitochondrial respiratory chain complex III assembly	protein transmembrane transporter activity|ATPase activity	mitochondrion|mitochondrial inner membrane
YBR171W	SEC66	hom	FF|FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0135224104362582	0.43376789371731	1273	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	posttranslational protein targeting to membrane, translocation|filamentous growth	protein transporter activity	integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YOR364W_d	YOR364W	hom			0.0135005183995222	0.434307014316722	1274	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C	Unknown	Unknown	Unknown
YOR218C_d	YOR218C	het			0.0134956009600503	0.434474430950288	1275	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W	Unknown	Unknown	Unknown
YOR354C	MSC6	hom	FT	CELL CYCLE|MITOCHONDRION	0.0134695767684386	0.435429520608013	1276	Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	reciprocal meiotic recombination	molecular_function	mitochondrion
YMR224C	MRE11	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION	0.0134681561111715	0.435409488267184	1277	Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress	DNA repair|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|base-excision repair|ascospore formation|meiotic DNA double-strand break processing|double-strand break repair via break-induced replication|regulation of transcription during meiosis	3'-5' exonuclease activity|protein complex scaffold|double-stranded telomeric DNA binding|adenylate kinase activity|telomeric DNA binding|single-stranded telomeric DNA binding|endodeoxyribonuclease activity|G-quadruplex DNA binding|endonuclease activity	mitochondrion|nucleus|Mre11 complex
YKL057C	NUP120	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0134666944416463	0.435459320478896	1278	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160	double-strand break repair|protein export from nucleus|ribosomal large subunit export from nucleus|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore outer ring
YML122C_d	YML122C	hom	FF		0.0134558521483058	0.436651379811478	1279	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR211W	ZPR1	het	FT	CELL CYCLE|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0134524534173036	0.436287316211567	1280	Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress	regulation of mitotic cell cycle|cellular response to starvation	protein binding	nucleus|cytoplasm
YJL080C	SCP160	hom	FT	CELL CYCLE|SIGNALING|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0134029259242397	0.437704888047161	1281	Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins	meiotic telomere clustering|pheromone-dependent signal transduction involved in conjugation with cellular fusion|chromosome segregation|intracellular mRNA localization|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	G-protein alpha-subunit binding|RNA binding	endoplasmic reticulum membrane|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YGL001C	ERG26	het	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0133581508581378	0.439169040860793	1282	C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis	ergosterol biosynthetic process	C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity	endoplasmic reticulum|endoplasmic reticulum membrane
YGR021W_p	YGR021W	hom	FT	MITOCHONDRION	0.0133522600022434	0.439370891764098	1283	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YBL063W	KIP1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|CYTOSKELETON	0.0133436965043918	0.439664416014523	1284	Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions	mitotic anaphase B|microtubule depolymerization|spindle pole body separation|plasmid partitioning|mitotic sister chromatid segregation	microtubule motor activity|structural constituent of cytoskeleton	spindle microtubule|kinesin complex|spindle pole body
YER131W	RPS26B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME	0.0133404836750831	0.439774568641623	1285	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YLR443W	ECM7	hom	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS	0.0133315101286355	0.440082312688619	1286	Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency	fungal-type cell wall organization|calcium ion transport	molecular_function	integral to membrane
YEL042W	GDA1	hom	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0133283246593719	0.440191586725549	1287	Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate	protein glycosylation	guanosine-diphosphatase activity|uridine-diphosphatase activity	Golgi apparatus
YGL142C	GPI10	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0133272533850985	0.440228339112438	1288	Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog	GPI anchor biosynthetic process	dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity	integral to membrane
YKL066W_d	YKL066W	hom			0.0133229871942535	0.440374717492259	1289	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene YNK1	Unknown	Unknown	Unknown
YNR045W	PET494	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0133189085384307	0.440514687392896	1290	Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrion|mitochondrial inner membrane
YDR511W	ACN9	hom	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|MITOCHONDRION	0.0132996455628376	0.441516838816002	1291	Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes	carbon utilization|regulation of gluconeogenesis	molecular_function	mitochondrion|mitochondrial intermembrane space
YIL135C	VHS2	hom	FT	CELL CYCLE	0.0132961242151129	0.441297060829198	1292	Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p	G1/S transition of mitotic cell cycle	molecular_function	cytoplasm
YDR384C	ATO3	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION|PLASMA MEMBRANE	0.0132921145108466	0.441843679633824	1293	Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters	ammonium transport|nitrogen utilization|transmembrane transport	ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YPL160W	CDC60	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.0132858639414922	0.441649640161112	1294	Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA	leucyl-tRNA aminoacylation|DNA replication initiation	leucine-tRNA ligase activity	cytoplasm
YMR206W_p	YMR206W	hom			0.0132720703540546	0.442123890637649	1295	Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YER183C	FAU1	hom	FT	COFACTOR METABOLISM|MITOCHONDRION	0.0132444770150608	0.443141478382943	1296	5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis	folic acid-containing compound biosynthetic process	5-formyltetrahydrofolate cyclo-ligase activity	mitochondrion
YDL097C	RPN6	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	0.0132395372444415	0.443447615931723	1297	Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress	proteasome assembly|ubiquitin-dependent protein catabolic process	structural molecule activity	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YFL010W-A	AUA1	hom			0.0132359650001351	0.443570639174736	1298	Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease	amino acid transport	molecular_function	cellular_component
YIL099W	SGA1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0132326635006124	0.443480378932645	1299	Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation	ascospore formation|glycogen catabolic process	glucan 1,4-alpha-glucosidase activity	fungal-type vacuole
YHR035W_p	YHR035W	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM	0.0132238503346671	0.443784076329864	1300	Putative protein of unknown function; not an essential gene	biological_process	molecular_function	cellular_component
YJL117W	PHO86	hom	FT	VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOPLASMIC RETICULUM	0.0132213082154389	0.443871698573661	1301	Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress	protein folding|ER to Golgi vesicle-mediated transport|regulation of phosphate transport	unfolded protein binding	endoplasmic reticulum
YML036W	CGI121	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|CHROMOSOME	0.0132187607081667	0.444163404491223	1302	Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification	telomere maintenance|positive regulation of transcription from RNA polymerase II promoter	molecular_function	EKC/KEOPS complex
YBR263W	SHM1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0132119230763354	0.444195272824007	1303	Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine	serine family amino acid biosynthetic process|one-carbon metabolic process	glycine hydroxymethyltransferase activity	mitochondrion
YLR016C	PML1	hom	FT	RNA PROCESSING|RNA LOCALIZATION|NUCLEUS	0.0132018279679675	0.444611385576155	1304	Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p	mRNA export from nucleus|mRNA splicing, via spliceosome|maintenance of RNA location	molecular_function	RES complex|nucleus|cytoplasm
YHR046C	INM1	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|NUCLEUS	0.0131989001601548	0.444644490665206	1305	Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate	inositol phosphate dephosphorylation	inositol monophosphate 1-phosphatase activity	nucleus|cytoplasm
YGR121W-A_p	YGR121W-A	hom			0.0131900292379267	0.444950636190816	1306	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR013C	ARD1	hom	FT	CHROMATIN ORGANIZATION|RIBOSOME	0.0131773932252096	0.445386926634363	1307	Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress	histone acetylation|N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	cytosolic ribosome|NatA complex
YER166W	DNF1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION|GOLGI APPARATUS|PLASMA MEMBRANE	0.0131600553578772	0.445985956999443	1308	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase	intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity	phospholipid-translocating ATPase activity|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	mitochondrion|integral to membrane|plasma membrane
YJR127C	RSF2	hom	FT	NUCLEUS	0.0131588802738378	0.446026573220698	1309	Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YER030W	CHZ1	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS	0.0131560043797072	0.446125986016788	1310	Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress	chromatin remodeling	histone binding	chromatin assembly complex|nucleus
YNL326C	PFA3	hom	FT	MEMBRANE ORGANIZATION	0.0131412985158729	0.446634529722152	1311	Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions	vacuole fusion, non-autophagic|protein palmitoylation	palmitoyltransferase activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YHR041C	SRB2	hom	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|RNA POL II, HOLOENZYME	0.0131339830442598	0.446887628927715	1312	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding	core mediator complex
YOL020W	TAT2	hom	FT	PLASMA MEMBRANE	0.0131137047643238	0.447725094825526	1313	High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance	aromatic amino acid transport|tryptophan transport	high-affinity tryptophan transmembrane transporter activity|aromatic amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YMR041C	ARA2	hom	FT	OXIDATION-REDUCTION PROCESS	0.0131115702409926	0.447663570084013	1314	NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase	dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinose 1-dehydrogenase [NAD(P)+] activity	cellular_component
YIR027C	DAL1	hom			0.0131087485284446	0.447761313238443	1315	Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression	allantoin assimilation pathway	allantoinase activity	cellular_component
YPL216W_p	YPL216W	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS	0.0130842049897385	0.448612004143582	1316	Putative protein of unknown function; YPL216W is not an essential gene	biological_process	molecular_function	cellular_component
YOR007C	SGT2	hom	FT	PROTEIN LOCALIZATION	0.0130747832137517	0.448938810896313	1317	Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress	response to heat|posttranslational protein targeting to membrane	molecular_function	TRC complex|cytoplasm
YOR011W	AUS1	hom	FT	NUCLEOTIDE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE	0.0130617927946705	0.449524849416959	1318	Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen	sterol import	sterol-transporting ATPase activity	mitochondrion|integral to membrane|plasma membrane
YDL075W	RPL31A	hom	FT	TRANSLATION|RIBOSOME	0.0130520839977818	0.449726717532449	1319	Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication	cytoplasmic translation|regulation of translational fidelity	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR138C_p	YBR138C	hom			0.013036826138015	0.450256769248561	1320	Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene	biological_process	molecular_function	cytoplasm
YDR424C	DYN2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON	0.0130341295799847	0.450350483328535	1321	Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex	microtubule-based process|actin filament-based process|nuclear pore complex assembly	molecular_function	cytoplasmic dynein complex|cytoplasmic microtubule|peroxisome|nuclear pore
YFL063W_d	YFL063W	hom			0.0130136916183264	0.451331216237682	1322	Dubious open reading frame, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR042C	PUF2	hom			0.0130127222485291	0.451297385295856	1323	Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	mRNA binding	cytoplasm
YDL063C	SYO1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0129677107071141	0.452931910581791	1324	Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	ribosomal large subunit biogenesis	molecular_function	nucleus|cytoplasm
YMR126C_p	DLT1	hom			0.0129607544209062	0.452972120933253	1325	Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)	biological_process	molecular_function	cellular_component
YLL017W	YLL017W	hom	FT	SIGNALING	0.0129447488487846	0.453462995248951	1326	Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication	Ras protein signal transduction	Ras guanyl-nucleotide exchange factor activity	membrane
YLR039C	RIC1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS	0.012923985595481	0.454187768354258	1327	Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes	intracellular protein transport|retrograde transport, endosome to Golgi	guanyl-nucleotide exchange factor activity	nucleus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YHR003C	YHR003C	hom	FT	MITOCHONDRION	0.0129122761900255	0.454596790758015	1328	Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YGR046W	TAM41	het	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0128868376227363	0.45548610242374	1329	Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition	cardiolipin biosynthetic process|protein import into mitochondrial matrix	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YBR261C	TAE1	hom	FT	TRANSLATION	0.0128678348046419	0.456151063681891	1330	AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm	cytoplasmic translation|N-terminal peptidyl-proline dimethylation	N-terminal protein N-methyltransferase activity	cytosol|cytoplasm
YNL184C_p	YNL184C	hom			0.0128614850892679	0.456373379392313	1331	Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YOR037W	CYC2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0128584548758895	0.45647949443155	1332	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)	cytochrome c-heme linkage|mitochondrial membrane organization	oxidoreductase activity	extrinsic to mitochondrial inner membrane|mitochondrion
YDR432W	NPL3	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|NUCLEUS	0.0128531643314227	0.457269542764228	1333	RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress	translational termination|mRNA export from nucleus|negative regulation of translation|mRNA splicing, via spliceosome|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter	mRNA binding|RNA polymerase II core binding|eukaryotic initiation factor 4G binding|poly(A) RNA binding	nucleus|cytoplasm
YGL247W	BRR6	het	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|MEMBRANE ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS	0.0128527711557117	0.456678570007969	1334	Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism	mRNA export from nucleus|protein export from nucleus|cellular lipid metabolic process	molecular_function	nuclear envelope
YNL034W_p	YNL034W	hom			0.0128337719642302	0.457344381515809	1335	Putative protein of unknown function; YNL034W is not an essential gene	biological_process	molecular_function	cellular_component
YPR002W	PDH1	hom	FT	KETONE METABOLISM|MITOCHONDRION	0.0128281022618306	0.457543177217563	1336	Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate	propionate metabolic process|propionate catabolic process, 2-methylcitrate cycle	2-methylcitrate dehydratase activity	mitochondrial outer membrane|mitochondrion|cytoplasm
YJR019C	TES1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM|MITOCHONDRION	0.0128195214044435	0.458582575185796	1337	Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids	fatty acid beta-oxidation|fatty acid oxidation	acyl-CoA hydrolase activity	mitochondrion|peroxisome
YBR013C_p	YBR013C	hom			0.0128189479244461	0.457864256341413	1338	Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein	biological_process	molecular_function	cellular_component
YER067W	RGI1	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS|PLASMA MEMBRANE	0.0128131389264352	0.458068066596851	1339	Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress	energy reserve metabolic process	molecular_function	cell periphery|nucleus|cytoplasm
YLL049W	LDB18	hom	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0128064516344758	0.458302755011967	1340	Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24	establishment of mitotic spindle orientation	molecular_function	dynactin complex|cell cortex|spindle pole body|astral microtubule
YLR023C	IZH3	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0127951713459942	0.45896686125098	1341	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity	cellular zinc ion homeostasis	metal ion binding	integral to membrane|endoplasmic reticulum|membrane
YDR146C	SWI5	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS	0.0127921481258393	0.458804958373329	1342	Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication	positive regulation of mating type switching|regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter	RNA polymerase II distal enhancer sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|mediator complex binding	nucleus|cytoplasm
YJL174W	KRE9	het	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.0127909922375946	0.458845555648939	1343	Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects	(1->6)-beta-D-glucan metabolic process|fungal-type cell wall organization	molecular_function	extracellular region
YOR091W	TMA46	hom	FT	TRANSLATION	0.0127902948538981	0.458870050234218	1344	Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p	cytoplasmic translation	molecular_function	polysomal ribosome|ribosome|cytoplasm
YDR237W	MRPL7	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0127312301906496	0.460947266732913	1345	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YPL136W_d	YPL136W	hom			0.0127233564509218	0.4612245707801	1346	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C	Unknown	Unknown	Unknown
YGR036C	CAX4	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.012709306466483	0.461719626448512	1347	Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation	lipid biosynthetic process|protein N-linked glycosylation	dolichyldiphosphatase activity	integral to endoplasmic reticulum membrane|integral to membrane
YPL118W	MRP51	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0127033926117003	0.461994868200574	1348	Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences	mitochondrial translational initiation|mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YGL025C	PGD1	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0126814929907491	0.463034288417294	1349	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity	core mediator complex
YOL022C	TSR4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	0.012674590115439	0.462944139040116	1350	Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2	maturation of SSU-rRNA	molecular_function	cytoplasm
YIL157C	COA1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0126709694149434	0.463071952259206	1351	Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly	mitochondrial respiratory chain complex IV assembly	molecular_function	integral to mitochondrial membrane|mitochondrion|integral to mitochondrial inner membrane
YGR065C	VHT1	het	FT	PLASMA MEMBRANE	0.0126625151408647	0.463637272159785	1352	High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin	biotin transport	biotin transporter activity	integral to membrane|plasma membrane
YBR267W	REI1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION|RIBOSOME	0.0126544265791716	0.463656175825707	1353	Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network	ribosomal large subunit biogenesis|nucleocytoplasmic transport|mitotic cell cycle|budding cell bud growth	sequence-specific DNA binding	cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YER011W	TIR1	hom			0.0126316525375899	0.464461130398369	1354	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking	response to stress	structural constituent of cell wall	fungal-type cell wall
YOR152C_p	YOR152C	hom			0.0126125894541962	0.4651355173631	1355	Putative protein of unknown function; YOR152C is not an essential gene	biological_process	molecular_function	membrane
YPL021W	ECM23	hom	FT	CELL WALL ORG/BIOGENESIS	0.012583552196076	0.466230285092483	1356	Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p	pseudohyphal growth	sequence-specific DNA binding	cellular_component
YIL079C	AIR1	hom	FT	RNA PROCESSING|NUCLEUS	0.0125741427687004	0.466497284150072	1357	Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication	nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent snRNA catabolic process	polynucleotide adenylyltransferase activity	nucleolus|TRAMP complex
YEL047C	FRD1	hom	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0125684460818193	0.466699246571619	1358	Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication	cellular response to anoxia	fumarate reductase (NADH) activity	cytosol|mitochondrion|ribosome|plasma membrane
YCR020W-B	HTL1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|RSC COMPLEX	0.0125393581690936	0.468329150414266	1359	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance	regulation of cell cycle|nucleosome disassembly|response to DNA damage stimulus|chromatin remodeling|transcription elongation from RNA polymerase II promoter	chromatin binding	RSC complex
YNL230C	ELA1	hom	FT	PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0125215317435499	0.468364325156034	1360	Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	elongin complex|Cul3-RING ubiquitin ligase complex
YBL082C	ALG3	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0125098767878392	0.468778490823983	1361	Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins	oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation	alpha-1,3-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YMR222C	FSH2	hom			0.0125065744101798	0.468895879566265	1362	Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2	biological_process	molecular_function	cytoplasm
YLR192C	HCR1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	0.0124955985433992	0.469286152573451	1363	Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	translation initiation factor activity	eukaryotic translation initiation factor 3 complex
YLR061W	RPL22A	hom	FT	TRANSLATION|RIBOSOME	0.0124887520345177	0.469794762037162	1364	Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YPR100W	MRPL51	hom	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION|RIBOSOME	0.0124757714753451	0.470190290666455	1365	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation|aerobic respiration	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YLR280C_d	YLR280C	hom			0.0124622507411515	0.470473013669279	1366	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR012W	CLU1	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	0.0124287432948898	0.471667223224617	1367	eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant	translational initiation|mitochondrion organization	molecular_function	eukaryotic translation initiation factor 3 complex|cytoplasm
YOR096W	RPS7A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS|RIBOSOME	0.0124190983469681	0.472011279718606	1368	Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication	cytoplasmic translation|ribosome biogenesis	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YJL205C	NCE101	hom	FT	PROTEIN LOCALIZATION	0.0124135881278069	0.472340027004503	1369	Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences	protein secretion	molecular_function	cellular_component
YMR230W-A_p	YMR230W-A	hom			0.0123869450132174	0.473159257755831	1370	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YML050W	AIM32	hom			0.0123750482211769	0.473584400581137	1371	Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YNR043W	MVD1	het	FT	LIPID METABOLISM	0.0123473608370274	0.474574647245622	1372	Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer	sterol biosynthetic process	diphosphomevalonate decarboxylase activity	cytoplasm
YOR065W	CYT1	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0123432941523961	0.474983766886242	1373	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex	oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c	electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity	mitochondrion|mitochondrial respiratory chain|integral to membrane|mitochondrial inner membrane|mitochondrial respiratory chain complex III
YDR094W_d	YDR094W	hom			0.0122964017046506	0.476400181691147	1374	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2	Unknown	Unknown	Unknown
YBR058C	UBP14	hom	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS	0.0122962958260143	0.476403978633567	1375	Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T	protein deubiquitination|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	cytoplasm
YMR239C	RNT1	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|NUCLEUS	0.0122915754727869	0.476573273335812	1376	Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes	U5 snRNA 3'-end processing|mRNA cleavage|chromatin organization|termination of RNA polymerase II transcription, exosome-dependent|U4 snRNA 3'-end processing|U1 snRNA 3'-end processing|rRNA transcription|rRNA processing	ribonuclease III activity	nucleoplasm|nucleolus
YGR139W_d	YGR139W	hom			0.0122785785349592	0.477039576557686	1377	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR202C_d	YLR202C	hom			0.0122705316099101	0.477656960184805	1378	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron	Unknown	Unknown	Unknown
YLR154C	RNH203	hom	FT	NUCLEUS	0.0122536175221083	0.478198457683939	1379	Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome	RNA catabolic process|DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus|cytoplasm
YLR360W	VPS38	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0122429674816801	0.478318505602462	1380	Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated	ER-associated protein catabolic process|late endosome to vacuole transport	molecular_function	phosphatidylinositol 3-kinase complex II
YGR209C	TRX2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS|ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS	0.0122354777494155	0.478587728706252	1381	Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress	vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|sulfate assimilation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic	disulfide oxidoreductase activity	cytosol|fungal-type vacuole
YLR393W	ATP10	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0122318437191078	0.478718386003411	1382	Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6	mitochondrial proton-transporting ATP synthase complex assembly	unfolded protein binding	integral to mitochondrial membrane|mitochondrion|mitochondrial inner membrane
YPL163C	SVS1	hom			0.0122178947730328	0.479220084790895	1383	Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication	response to chemical stimulus	molecular_function	fungal-type cell wall|fungal-type vacuole
YDR046C	BAP3	hom	FT	MITOCHONDRION|PLASMA MEMBRANE	0.0122151362436694	0.479319334195686	1384	Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YGR146C-A_p	YGR146C-A	hom			0.0122136538458836	0.479372674166135	1385	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YAL015C	NTG1	hom	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|MITOCHONDRION	0.0122006796933606	0.479839651192715	1386	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication	DNA repair|cellular response to oxidative stress|base-excision repair|base-excision repair, AP site formation|positive regulation of mitochondrial DNA replication	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|oxidized purine nucleobase lesion DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity	mitochondrion|nucleus
YDR459C	PFA5	hom	FT	PLASMA MEMBRANE	0.0121860161866534	0.480367731319684	1387	Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain	protein palmitoylation	palmitoyltransferase activity	integral to membrane|plasma membrane
YPR016C	TIF6	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS	0.0121741418361906	0.480795596834174	1388	Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits	ribosomal subunit export from nucleus|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	ribosomal large subunit binding	nucleolus|nucleus|preribosome, large subunit precursor|cytoplasm
YBR195C	MSI1	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS	0.0121740370231882	0.480799374458616	1389	Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase	DNA replication-dependent nucleosome assembly	histone binding	nucleus|CAF-1 complex|cytoplasm
YIL008W	URM1	hom	FT	RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0121721722144984	0.480866587780086	1390	Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response	cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|invasive growth in response to glucose limitation|tRNA wobble uridine modification	protein tag	cytosol|nucleus|cytoplasm
YKL115C_d	YKL115C	hom			0.0121609145643301	0.481272456027327	1391	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1	Unknown	Unknown	Unknown
YKL173W	SNU114	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEOTIDE METABOLISM|NUCLEUS	0.0121491244138201	0.481697722079108	1392	GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2	assembly of spliceosomal tri-snRNP|spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step	GTP binding|GTPase activity|U5 snRNA binding	U4/U6 x U5 tri-snRNP complex|U5 snRNP
YPR153W	YPR153W	hom			0.0121462609383158	0.481801037337996	1393	Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YDR045C	RPC11	het	FT	NUCLEUS	0.0121432062142687	0.481911266196484	1394	RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS	termination of RNA polymerase III transcription|tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YBR293W	VBA2	hom			0.0121043117963154	0.483315958220191	1395	Permease of basic amino acids in the vacuolar membrane	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity|drug transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YPR191W	QCR2	hom	FT	OXIDATION-REDUCTION PROCESS|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0120921744164481	0.483754760377404	1396	Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial crista|mitochondrial respiratory chain complex III
YMR194C-B	CMC4	hom	FT	MITOCHONDRION	0.0120900836763415	0.483830368619231	1397	Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs	biological_process	molecular_function	mitochondrial intermembrane space
YNL229C	URE2	hom	FF|FT	PROTEIN LOCALIZATION	0.0120826516329765	0.484099188340694	1398	Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion	regulation of nitrogen utilization|response to aluminum ion|protein urmylation|cytoplasmic sequestering of transcription factor	glutathione peroxidase activity|phosphoprotein binding|transcription corepressor activity	cytosol
YOR076C	SKI7	hom	FT	TRANSLATION|NUCLEOTIDE METABOLISM	0.0120814811066675	0.484141534083031	1399	Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay|nonfunctional rRNA decay	protein binding, bridging	Ski complex|cytoplasmic exosome (RNase complex)|cytoplasm
YDR017C	KCS1	hom			0.012049287652619	0.485306972596142	1400	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance	inositol phosphate biosynthetic process	inositol heptakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol heptakisphosphate 5-kinase activity	cytoplasm
YFL013W-A_d	YFL013W-A	hom			0.0120413962919895	0.486570283424486	1401	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching	Unknown	Unknown	Unknown
YOR055W_d	YOR055W	hom			0.0120375583399245	0.48573196368435	1402	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER150W	SPI1	hom			0.0120332366199853	0.486148836514729	1403	GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p	response to acid	molecular_function	fungal-type cell wall
YOR027W	STI1	hom			0.0120023877655217	0.487007513650987	1404	Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop	protein folding	Hsp70 protein binding|Hsp90 protein binding|mRNA binding|ATPase inhibitor activity	cytoplasm
YGL009C	LEU1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0119927435443963	0.487357601460605	1405	Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway	leucine biosynthetic process	3-isopropylmalate dehydratase activity	cytosol
YBL107C	MIC23	hom			0.0119773278744715	0.487917476345844	1406	Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C)	biological_process	molecular_function	cytoplasm
YHR021C	RPS27B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0119598061403694	0.488554261375221	1407	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YOL038W	PRE6	het	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	0.0119407597053529	0.489246965586736	1408	Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YIL022W	TIM44	het	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0119383170436154	0.48933584155225	1409	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)	protein import into mitochondrial matrix	protein binding, bridging|chaperone binding	mitochondrion|integral to membrane|presequence translocase-associated import motor
YJL142C_d	IRC9	hom			0.0119277335015935	0.489721022881105	1410	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci	Unknown	Unknown	Unknown
YDL010W	GRX6	hom	FT	RESPONSE TO OXIDATIVE STRESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0119259137719374	0.489787267222143	1411	Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication	cellular response to oxidative stress	glutathione-disulfide reductase activity|iron ion binding|protein homodimerization activity|2 iron, 2 sulfur cluster binding	integral to membrane|Golgi apparatus|Golgi lumen|endoplasmic reticulum membrane|fungal-type vacuole|cis-Golgi network
YMR096W	SNZ1	hom	FT	COFACTOR METABOLISM	0.0119191999111373	0.490355437577629	1412	Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins	pyridoxine metabolic process|thiamine biosynthetic process	protein binding	cellular_component
YDR055W	PST1	hom	FT	CELL WALL ORG/BIOGENESIS|PLASMA MEMBRANE	0.0119110479051036	0.490976182801693	1413	Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1	fungal-type cell wall organization	molecular_function	fungal-type cell wall|plasma membrane
YPL226W	NEW1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|NUCLEUS|MITOCHONDRION	0.0118980706002522	0.490801454084122	1414	ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction	ribosomal small subunit biogenesis|poly(A)+ mRNA export from nucleus	ATPase activity|ATP binding	mitochondrion|polysome|cytoplasm
YOL129W	VPS68	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|MITOCHONDRION	0.011894809798426	0.490920302460513	1415	Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria	late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole	molecular_function	Vps55/Vps68 complex|mitochondrion|fungal-type vacuole membrane|integral to membrane
YNL201C	PSY2	hom	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.011887257412642	0.491260252740899	1416	Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3	Unknown|response to DNA damage stimulus|protein dephosphorylation|signal transduction involved in meiotic recombination checkpoint	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus
YDR395W	SXM1	hom	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS	0.0118741265480784	0.491674516969962	1417	Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1	mRNA export from nucleus|nucleocytoplasmic transport	protein transporter activity	integral to membrane|nucleus|cytoplasm
YBR162C	TOS1	hom			0.0118646079526421	0.492474037138491	1418	Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C	biological_process	molecular_function	fungal-type cell wall|fungal-type vacuole
YKR063C	LAS1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION	0.0118612548661945	0.492208746441302	1419	Protein required for pre-rRNA processing at both ends of ITS2; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S transition of the cell cycle; human ortholog is Las1L; mutants require the SSD1-v allele for viability	maturation of LSU-rRNA|maturation of 5.8S rRNA	molecular_function	mitochondrion|nucleus|preribosome|cytoplasm
YJL112W	MDV1	hom	FT	MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION|MITOCHONDRION	0.011846948795816	0.492666497801093	1420	Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication	peroxisome fission|mitochondrial fission|mitochondrial genome maintenance	ubiquitin binding	mitochondrial outer membrane|mitochondrion
YNL321W	VNX1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0118217219240834	0.493588230767298	1421	Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate	potassium ion transport|sodium ion transport|hydrogen transport	potassium:hydrogen antiporter activity|sodium:hydrogen antiporter activity|calcium:hydrogen antiporter activity	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum membrane|fungal-type vacuole
YEL072W	RMD6	hom	FT	CELL CYCLE	0.0118113447427495	0.493967657256989	1422	Protein required for sporulation	biological_process	molecular_function	cellular_component
YOL041C	NOP12	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0117835611310958	0.495177309339015	1423	Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RNA binding	nucleolus|preribosome
YBR170C	NPL4	hom	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX	0.0117683726000396	0.495540530042003	1424	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)	retrograde protein transport, ER to cytosol|proteasomal ubiquitin-dependent protein catabolic process|mitochondria-associated protein catabolic process|mitotic spindle disassembly|ER-associated protein catabolic process|ER-associated misfolded protein catabolic process|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process	molecular_function	Doa10p ubiquitin ligase complex|integral to membrane|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|Cdc48p-Npl4p-Vms1p AAA ATPase complex|nuclear outer membrane-endoplasmic reticulum membrane network
YDR070C	FMP16	hom	FT	MITOCHONDRION	0.0117361580554065	0.496721402224481	1425	Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrion
YLR207W	HRD3	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX	0.0117345101352856	0.496781849479451	1426	Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events	ER-associated protein catabolic process	ubiquitin-protein ligase activity	Hrd1p ubiquitin ligase ERAD-M complex|luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YPL164C	MLH3	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0117291331447796	0.496979109784812	1427	Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability	mismatch repair|reciprocal meiotic recombination	molecular_function	nucleus|MutLbeta complex
YGL077C	HNM1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0117216399019714	0.497254076499173	1428	Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol	choline transport|ethanolamine transport|glycine betaine transport	choline transmembrane transporter activity|ethanolamine transmembrane transporter activity	integral to membrane|plasma membrane
YIL068C	SEC6	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH	0.0117186189374987	0.497429089025524	1429	Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p	exocyst localization|Golgi to plasma membrane transport|exocytosis|vesicle fusion|negative regulation of SNARE complex assembly|vesicle docking involved in exocytosis	protein homodimerization activity	mating projection tip|cellular bud neck|cellular bud tip|exocyst
YLR038C	COX12	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0117061511494869	0.497822697409519	1430	Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV	mitochondrial respiratory chain complex IV assembly	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YMR008C	PLB1	hom	FT	LIPID METABOLISM|PLASMA MEMBRANE	0.01168995106784	0.498417802453744	1431	Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol	glycerophospholipid metabolic process	lysophospholipase activity	periplasmic space|plasma membrane
YHR048W_p	YHK8	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.0116851120618609	0.498595635177821	1432	Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles	drug transport	molecular_function	integral to membrane
YMR219W	ESC1	hom	FT	GENE SILENCING|NUCLEUS	0.0116838496883753	0.498642032753913	1433	Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p	chromatin silencing at telomere	molecular_function	nuclear periphery
YEL004W	YEA4	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.011682315969555	0.498890528961504	1434	Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER	fungal-type cell wall chitin biosynthetic process|UDP-N-acetylglucosamine transport|UDP-glucose transport|transmembrane transport	UDP-N-acetylglucosamine transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YER069W	ARG5,6	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0116604587257399	0.499502164737716	1435	Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine	ornithine biosynthetic process|arginine biosynthetic process|regulation of transcription, DNA-dependent	N-acetyl-gamma-glutamyl-phosphate reductase activity|acetylglutamate kinase activity	mitochondrion|mitochondrial matrix
YJR108W	ABM1	hom	FT	CYTOSKELETON ORGANIZATION	0.0116543846398292	0.499725649623402	1436	Protein of unknown function, required for normal microtubule organization	microtubule cytoskeleton organization	molecular_function	cellular_component
YJL037W	IRC18	hom			0.0116513286099313	0.499838110714443	1437	Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YOR202W	HIS3	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0116507588094775	0.499859080705265	1438	Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p	histidine biosynthetic process	imidazoleglycerol-phosphate dehydratase activity	cellular_component
YEL022W	GEA2	hom	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|GOLGI APPARATUS	0.0116485106517088	0.499941822728162	1439	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication	retrograde vesicle-mediated transport, Golgi to ER|secretory granule organization|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization	ARF guanyl-nucleotide exchange factor activity	integral to membrane|Golgi cis cisterna|extrinsic to membrane
YBL034C	STU1	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|CHROMOSOME|CYTOSKELETON	0.0116391903887484	0.500284926581395	1440	Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles	microtubule nucleation	structural constituent of cytoskeleton	spindle pole body
YGL171W	ROK1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION|NUCLEUS	0.0116214215983496	0.500939389088883	1441	RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|snoRNA localization	RNA-dependent ATPase activity	nucleolus|90S preribosome
YOR352W	TFB6	hom	FT	NUCLEUS	0.0116187088153616	0.501039346570015	1442	Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|holo TFIIH complex|cytoplasm
YDR390C	UBA2	het	FT	NUCLEUS	0.0116177069609928	0.501076264408629	1443	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability	protein sumoylation	SUMO activating enzyme activity	SUMO activating enzyme complex|nucleus
YBR193C	MED8	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0116122420200062	0.501277670143838	1444	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	TBP-class protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription corepressor activity|structural molecule activity	core mediator complex
YDR408C	ADE8	hom	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.0116102148225093	0.501607719180104	1445	Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process|adenine biosynthetic process	phosphoribosylglycinamide formyltransferase activity	nucleus|cytoplasm
YJR031C	GEA1	hom	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|GOLGI APPARATUS	0.011586122624742	0.502240869824324	1446	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization	ARF guanyl-nucleotide exchange factor activity	integral to membrane|Golgi cis cisterna|Golgi-associated vesicle|extrinsic to membrane
YKL215C	OXP1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0115808706376891	0.502434664392058	1447	5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	glutathione metabolic process	5-oxoprolinase (ATP-hydrolyzing) activity	cytoplasm
YLR077W	FMP25	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0115589488457522	0.503243989468777	1448	Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria	mitochondrial respiratory chain complex III assembly	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YIL143C	SSL2	het	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|RNA LOCALIZATION|NUCLEUS|RNA POL II, HOLOENZYME	0.011549353894455	0.503598439489045	1449	Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3	poly(A)+ mRNA export from nucleus|promoter clearance from RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|nucleotide-excision repair, DNA incision|transcription from RNA polymerase II promoter|phosphorylation of RNA polymerase II C-terminal domain|regulation of transposition, RNA-mediated|regulation of mitotic recombination	ATP-dependent DNA helicase activity|core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YKR072C	SIS2	hom	FF|FT	CELL CYCLE|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.0115285686615615	0.504621060577291	1450	Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis	regulation of mitotic cell cycle|response to salt stress|coenzyme A biosynthetic process	phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity	phosphopantothenoylcysteine decarboxylase complex|nucleus|cytoplasm
YMR149W	SWP1	het	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0115210293010244	0.504645554959848	1451	Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum	protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex|integral to membrane
YLR022C	SDO1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0115097418873262	0.505063152283026	1452	Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes	mature ribosome assembly	molecular_function	nucleus|preribosome, large subunit precursor|polysome|cytoplasm
YNL232W	CSL4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0114925572578552	0.505826196161434	1453	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)	nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing	molecular_function	nucleus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|cytoplasm
YFL033C	RIM15	hom	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.011491596160463	0.506115771047211	1454	Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase	protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|response to stress|regulation of meiosis	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YOL095C	HMI1	hom	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0114860894546997	0.505938804674117	1455	Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD	mitochondrial genome maintenance|mitochondrial DNA metabolic process	ATP-dependent 3'-5' DNA helicase activity	mitochondrion|mitochondrial matrix
YDL066W	IDP1	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0114855825124885	0.50595758125488	1456	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes	isocitrate metabolic process|glutamate biosynthetic process	isocitrate dehydrogenase (NADP+) activity	mitochondrial nucleoid|mitochondrion
YBR084C-A	RPL19A	hom	FT	TRANSLATION|RIBOSOME	0.0114796742723649	0.507447306832919	1457	Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOR190W	SPR1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.0114775090922534	0.506256661234082	1458	Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance	ascospore formation	glucan exo-1,3-beta-glucosidase activity	fungal-type cell wall|ascospore wall
YCR016W_p	YCR016W	hom	FT	NUCLEUS	0.0114135534756319	0.508629178761077	1459	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	nucleolus|nucleus
YMR299C	DYN3	hom	FT	CYTOSKELETON	0.0114007677540565	0.509104179685782	1460	Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration	nuclear migration along microtubule	motor activity	cytoplasmic dynein complex|cytoplasmic microtubule
YPR094W	RDS3	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0113989511063215	0.509171688605747	1461	Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance	spliceosomal complex assembly|response to xenobiotic stimulus|mRNA splicing, via spliceosome	molecular_function	U2 snRNP
YLR165C	PUS5	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION	0.0113980839267514	0.509203915744385	1462	Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability	rRNA modification|pseudouridine synthesis	pseudouridylate synthase activity	mitochondrion
YLR450W	HMG2	hom	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0113652623489069	0.510550581666709	1463	HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at the nuclear periphery upon DNA replication stress	ergosterol biosynthetic process	hydroxymethylglutaryl-CoA reductase (NADPH) activity	nuclear envelope|integral to membrane|endoplasmic reticulum membrane
YPL114W_d	YPL114W	hom			0.0113528475736851	0.510886521598013	1464	Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index	Unknown	Unknown	Unknown
YKL010C	UFD4	hom	FT	PROTEOLYSIS|MITOCHONDRION	0.0113244678196957	0.512258387405981	1465	Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress	protein monoubiquitination|protein polyubiquitination	ubiquitin-protein ligase activity	mitochondrion|cytoplasm
YDR064W	RPS13	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0113100833542915	0.512479840436511	1466	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome|SSU rRNA binding	cytosolic small ribosomal subunit|90S preribosome
YDL141W	BPL1	het	FT	NUCLEUS	0.0113053635605762	0.512655850097449	1467	Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation	protein biotinylation	biotin-[pyruvate-carboxylase] ligase activity|biotin-[acetyl-CoA-carboxylase] ligase activity	nucleus|cytoplasm
YNL078W	NIS1	hom	FT	CELL CYCLE|NUCLEUS|SITE OF POLARIZED GROWTH	0.0112736931202841	0.513837712365823	1468	Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network	regulation of mitosis	molecular_function	nucleus|cellular bud neck
YKL149C	DBR1	hom	FT	RNA PROCESSING|NUCLEUS	0.0112709364771052	0.514003408350534	1469	RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition	snoRNA metabolic process|pseudohyphal growth|RNA catabolic process|transposition, RNA-mediated	RNA lariat debranching enzyme activity	nucleus
YIR029W	DAL2	hom			0.0112649653845108	0.514163658700453	1470	Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process	allantoicase activity	cellular_component
YJR079W_p	YJR079W	hom			0.0112645549022463	0.514869838213035	1471	Putative protein of unknown function; mutation results in impaired mitochondrial respiration	biological_process	molecular_function	cellular_component
YGR079W_p	YGR079W	hom			0.011264098033881	0.514196056678845	1472	Putative protein of unknown function; YGR079W is not an essential gene	biological_process	molecular_function	cellular_component
YGR095C	RRP46	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0112565315573771	0.514478730796698	1473	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)	nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing	molecular_function	nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YBR232C_d	YBR232C	hom			0.0112532362032474	0.51460186635003	1474	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNR060W	FRE4	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|PLASMA MEMBRANE	0.0112486666621003	0.514835325612582	1475	Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels	siderophore transport	ferric-chelate reductase activity	integral to membrane|plasma membrane
YMR001C-A_p	YMR001C-A	hom			0.011245867565148	0.514877261286946	1476	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL028W	ERG10	het	FT	LIPID METABOLISM	0.0112408147894832	0.515066147577152	1477	Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis	ergosterol biosynthetic process	acetyl-CoA C-acetyltransferase activity	cytosol
YGL236C	MTO1	hom	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0112357409327058	0.515255858130237	1478	Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants	mitochondrial tRNA wobble uridine modification	molecular_function	mitochondrion
YCL061C	MRC1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0112257992519775	0.515627680828755	1479	S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres	maintenance of DNA repeat elements|intra-S DNA damage checkpoint|DNA repair|DNA replication checkpoint|telomere maintenance|replication fork protection|DNA replication|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	molecular_function	nuclear chromosome|replication fork protection complex|nucleus|nuclear replication fork
YNL016W	PUB1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEUS	0.0112224111487744	0.516192923159008	1480	Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|stress granule assembly|regulation of mRNA stability	mRNA binding|poly(U) RNA binding	nucleus|cytoplasmic stress granule|cytoplasm
YDR274C_d	YDR274C	hom			0.0112216698972304	0.516220638618343	1481	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCL051W	LRE1	hom	FT	CELL WALL ORG/BIOGENESIS	0.0112202301574181	0.515836027923014	1482	Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; <br>LRE1 has a paralog, HLR1, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cellular_component
YOR034C	AKR2	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|GOLGI APPARATUS	0.0112199193248972	0.51584765785943	1483	Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication	endocytosis|protein palmitoylation	palmitoyltransferase activity	integral to membrane|Golgi apparatus
YLR275W	SMD2	het	FT	RNA PROCESSING|NUCLEUS	0.0112114502878836	0.516728162150431	1484	Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2	mRNA splicing, via spliceosome	molecular_function	U1 snRNP|U4/U6 x U5 tri-snRNP complex|U2-type prespliceosome|U5 snRNP
YDL107W	MSS2	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0112113741278183	0.51616743343638	1485	Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p	protein insertion into mitochondrial membrane from inner side	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrial matrix
YLR124W_d	YLR124W	hom			0.0112110892913718	0.516178094262236	1486	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR139W	RIM11	hom	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION	0.0112093999006909	0.516241326928722	1487	Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress	proteolysis|ascospore formation|protein phosphorylation|response to stress	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YEL026W	SNU13	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0112056441315992	0.516444465064236	1488	RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mRNA splicing, via spliceosome	RNA binding	box C/D snoRNP complex|small-subunit processome|nucleolus|U4/U6 x U5 tri-snRNP complex
YKL006W	RPL14A	hom	FT	TRANSLATION|RIBOSOME	0.0111924881278595	0.516937048967475	1489	Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YJL054W	TIM54	het	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0111907560613024	0.51693941883236	1490	Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane	protein import into mitochondrial inner membrane	protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YPL116W	HOS3	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS|SITE OF POLARIZED GROWTH	0.0111882908709764	0.517031760931395	1491	Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats	regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation	histone deacetylase activity	nucleus|cellular bud neck|cytoplasm
YPL107W_p	YPL107W	hom	FT	MITOCHONDRION	0.0111862311628826	0.517108920860079	1492	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene	biological_process	molecular_function	mitochondrion
YKL116C	PRR1	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION	0.0111744416822234	0.517550688158264	1493	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor	negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation	protein kinase activity|receptor signaling protein serine/threonine kinase activity	cytoplasm
YNL024C_p	YNL024C	hom			0.0111716349522854	0.517655888773638	1494	Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cytoplasm
YKR064W	OAF3	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION	0.0111579632446674	0.518980627637152	1495	Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|cellular response to oleic acid	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity	mitochondrion|nucleus|cytoplasm
YCR028C-A	RIM1	hom	FT	MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0111578692287181	0.518172009660591	1496	Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication	mitochondrial DNA replication|mitochondrial genome maintenance	single-stranded DNA binding	mitochondrial nucleoid|mitochondrion
YBR300C_d	YBR300C	hom			0.0111550040046806	0.518279469478983	1497	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene	Unknown	Unknown	Unknown
YOR171C	LCB4	hom	FT	LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE	0.0111488840218976	0.518509037121606	1498	Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes	calcium-mediated signaling|sphingolipid metabolic process	D-erythro-sphingosine kinase activity	Golgi apparatus|endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum
YIL072W	HOP1	hom	FT	CELL CYCLE|NUCLEUS|CHROMOSOME	0.0111309629247467	0.519181580226935	1499	Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments	synaptonemal complex assembly|meiotic recombination checkpoint|synapsis	four-way junction DNA binding	condensed nuclear chromosome|lateral element
YJR078W	BNA2	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.0111103180289113	0.519956899720282	1500	Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp	de novo NAD biosynthetic process from tryptophan	tryptophan 2,3-dioxygenase activity|indoleamine 2,3-dioxygenase activity	cytoplasm
YDL028C	MPS1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.0110608454275595	0.521817270119896	1501	Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p	protein phosphorylation|sister chromatid biorientation|spindle assembly|spindle pole body duplication associated with nuclear envelope|mitotic cell cycle spindle assembly checkpoint	protein serine/threonine/tyrosine kinase activity|protein kinase activity	condensed nuclear chromosome kinetochore|spindle pole body
YJL058C	BIT61	hom	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE	0.0110439545641156	0.52245321774411	1502	Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication	fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity	molecular_function	TORC2 complex|plasma membrane|cytoplasm
YDR530C	APA2	hom	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.0110245861316341	0.523182936424327	1503	Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication	nucleoside catabolic process	bis(5'-nucleosyl)-tetraphosphatase activity	nucleus|cytoplasm
YDR287W	INM2	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	0.0109971981356454	0.524649000408897	1504	Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy	inositol phosphate dephosphorylation	inositol monophosphate 1-phosphatase activity	cellular_component
YBR224W_d	YBR224W	hom			0.0109927880365405	0.52438208388814	1505	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1	Unknown	Unknown	Unknown
YKL181W	PRS1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM	0.0109823267737079	0.524776899188606	1506	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YLR223C	IFH1	het	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0109551137519876	0.52580464966865	1507	Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing	positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|chromatin silencing at telomere	transcription coactivator activity	nuclear chromatin|nucleolus|nucleus|CURI complex
YAL045C_d	YAL045C	hom			0.010949922934454	0.526000807321966	1508	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A	Unknown	Unknown	Unknown
YKR004C	ECM9	het	FT	CELL WALL ORG/BIOGENESIS	0.010949100820374	0.526031877913127	1509	Non-essential protein of unknown function	fungal-type cell wall organization	molecular_function	cellular_component
YLR431C	ATG23	hom	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.0109375939569198	0.526466861259293	1510	Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p	protein localization to pre-autophagosomal structure|positive regulation of macroautophagy|CVT pathway	molecular_function	pre-autophagosomal structure|extrinsic to membrane
YIR010W	DSN1	het	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.0109271033035974	0.526863589721394	1511	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation	chromosome segregation	molecular_function	nuclear MIS12/MIND type complex|kinetochore|spindle pole
YER056C	FCY2	hom	FT	PLASMA MEMBRANE	0.0109210119040421	0.527094020150823	1512	Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress	cytosine transport|cytidine transport|purine nucleobase transport|transmembrane transport	nucleobase transmembrane transporter activity|cytidine transmembrane transporter activity	integral to membrane|plasma membrane
YOL044W	PEX15	hom	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0109110109185135	0.527472457039452	1513	Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly	protein import into peroxisome matrix, receptor recycling	protein anchor	integral to peroxisomal membrane
YCL064C	CHA1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0108952550681288	0.528068938654395	1514	Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine	threonine catabolic process|L-serine catabolic process	L-threonine ammonia-lyase activity|L-serine ammonia-lyase activity	mitochondrial nucleoid|mitochondrion
YML113W	DAT1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0108840632120325	0.5284928461443	1515	DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability	negative regulation of transcription from RNA polymerase II promoter	AT DNA binding	nucleus
YNL117W	MLS1	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	0.0108556389504501	0.529570233566551	1516	Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic	glyoxylate cycle	malate synthase activity	peroxisomal matrix|cytoplasm
YML116W	ATR1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0108405091160438	0.530144166568303	1517	Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	borate transport|drug transmembrane transport	drug transmembrane transporter activity|borate transmembrane transporter activity	integral to membrane|plasma membrane|vacuole
YER071C_p	TDA2	hom	FT	SITE OF POLARIZED GROWTH	0.0108186348741791	0.531526269756504	1518	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	mating projection tip|cytoplasm
YJL161W_p	FMP33	hom	FT	MITOCHONDRION	0.0107997599630603	0.531691508390785	1519	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YLR312W-A	MRPL15	hom	FT	RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0107602082442654	0.533378768624953	1520	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOR066W	MSA1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS	0.0107542256872824	0.533423255078765	1521	Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation	G1/S transition of mitotic cell cycle|regulation of transcription involved in G1 phase of mitotic cell cycle|regulation of cell size	molecular_function	nucleus|cytoplasm
YML082W_p	YML082W	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0107270251024669	0.534459097952511	1522	Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene	sulfur compound metabolic process	carbon-sulfur lyase activity	nucleus|cytoplasm
YOL114C_p	YOL114C	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	0.0107246156557553	0.534550902532553	1523	Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene	biological_process	molecular_function	cellular_component
YDL142C	CRD1	hom	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.0107085630348178	0.535162741387011	1524	Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis	lipid biosynthetic process|cellular ion homeostasis|mitochondrial membrane organization	cardiolipin synthase activity	mitochondrion|integral to membrane
YFR032C_p	RRT5	hom			0.0106810267271155	0.536213097319292	1525	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation	biological_process	molecular_function	cellular_component
YGL149W_d	YGL149W	hom			0.0106701318782587	0.536628960961611	1526	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.	Unknown	Unknown	Unknown
YLR044C	PDC1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.0106681668962283	0.536703982892819	1527	Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism	L-phenylalanine catabolic process|pyruvate metabolic process|glucose catabolic process to ethanol|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	pyruvate decarboxylase activity	cytosol|nucleus|cytoplasm
YCL074W	YCL074W	hom	FT	NUCLEUS	0.0106493313360559	0.537423381606783	1528	Pseudogene: encodes fragment of Ty Pol protein	transposition, RNA-mediated	ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity	retrotransposon nucleocapsid
YGR240C	PFK1	hom	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0106489485682485	0.537620039831079	1529	Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes	proton transport|glycolysis	6-phosphofructokinase activity	mitochondrion|6-phosphofructokinase complex|cytoplasm
YML097C	VPS9	hom	FF|FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	0.0106452270547468	0.537580203302913	1530	A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin	vacuole inheritance|protein targeting to vacuole	ubiquitin binding|guanyl-nucleotide exchange factor activity	cytosol
YNR032W	PPG1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.0106438489732918	0.537632863975667	1531	Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases	glycogen metabolic process|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YOR155C	ISN1	hom	FT	NUCLEOTIDE METABOLISM	0.0106391205050424	0.537813572775967	1532	Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms	nicotinamide riboside biosynthetic process|inosine salvage|nicotinic acid riboside biosynthetic process	IMP 5'-nucleotidase activity	cellular_component
YIR026C	YVH1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|CELL WALL ORG/BIOGENESIS|NUCLEUS	0.0106305643913746	0.538140640920357	1533	Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases	meiosis|ascospore wall assembly|ribosomal large subunit assembly|cAMP-mediated signaling|protein dephosphorylation	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	nucleus|preribosome, large subunit precursor|cytoplasm
YLR254C	NDL1	hom	FT	CELL CYCLE|CELL DIVISION|NUCLEUS|CYTOSKELETON	0.0105923596799498	0.539602280129954	1534	Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends	nuclear migration along microtubule	microtubule plus-end binding	cytoplasmic microtubule|nucleus|cytoplasm
YBR089W_d	YBR089W	het			0.01059139422079	0.539639242475489	1535	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30	Unknown	Unknown	Unknown
YCL076W_d	YCL076W	hom			0.0105630701786556	0.540724184410841	1536	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL023C	PET130	hom	FT	MITOCHONDRION	0.0105518954520302	0.541152527777357	1537	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YML131W	YML131W	hom	FT	OXIDATION-REDUCTION PROCESS	0.0105495981706169	0.541240606872912	1538	Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cytoplasm
YKL168C	KKQ8	hom	FT	PROTEIN PHOSPHORYLATION	0.0105421808575187	0.541947297438359	1539	Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication	biological_process	protein kinase activity	cytoplasm
YOR111W_p	YOR111W	hom			0.0105283854816119	0.542054251617087	1540	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKL182W	FAS1	het	FF|FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0105192926453864	0.542583854317068	1541	Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities	fatty acid biosynthetic process	palmitoyltransferase activity|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|fatty acid synthase activity|3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity	cytosol|fatty acid synthase complex|mitochondrion|lipid particle|cytoplasm
YKL127W	PGM1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0105136879242792	0.542618356081961	1542	Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism	glucose 6-phosphate metabolic process|galactose catabolic process|glucose 1-phosphate metabolic process|UDP-glucose metabolic process|trehalose biosynthetic process|glycogen biosynthetic process	phosphoglucomutase activity	cytoplasm
YIL094C	LYS12	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0104972543507047	0.543249436404233	1543	Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate	lysine biosynthetic process	homoisocitrate dehydrogenase activity	mitochondrion
YPR183W	DPM1	het	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0104797373888282	0.543982583246892	1544	Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation	GPI anchor biosynthetic process|protein O-linked glycosylation|protein N-linked glycosylation	dolichyl-phosphate beta-D-mannosyltransferase activity	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YHR087W	RTC3	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0104655770699046	0.544526942770237	1545	Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress	RNA metabolic process	molecular_function	nucleus|cytoplasm
YOR006C	TSR3	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0104633081909022	0.544554188675861	1546	Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress	maturation of SSU-rRNA	molecular_function	nucleus|cytoplasm
YCR068W	ATG15	hom	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.010458350403033	0.544744876043934	1547	Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway	membrane disassembly|autophagy|piecemeal microautophagy of nucleus|vacuolar protein processing|multivesicular body membrane disassembly	lipase activity	integral to membrane|vacuolar lumen
YKL159C	RCN1	hom	FT	SIGNALING	0.0104500174734944	0.545065453419338	1548	Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region	calcium-mediated signaling	protein phosphatase 2B binding|calcium-dependent protein serine/threonine phosphatase regulator activity	cytoplasm
YGL074C_d	YGL074C	het			0.0104461639993328	0.545213732650916	1549	Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor	Unknown	Unknown	Unknown
YPL264C_p	YPL264C	hom			0.0104443454468512	0.545283716342744	1550	Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene	biological_process	molecular_function	integral to membrane
YAL016C-B_d	YAL016C-B	hom			0.0104371131954864	0.54556208050711	1551	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR228C	PCF11	het	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.0104193926132722	0.546663573225365	1552	mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping	mRNA cleavage|termination of RNA polymerase II transcription|mRNA polyadenylation	mRNA binding|RNA polymerase II core binding	mRNA cleavage factor complex
YPR027C_p	YPR027C	hom			0.0104152353341346	0.546404572450377	1553	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJR131W	MNS1	hom	FT	CARBOHYDRATE METABOLISM|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.010375912170083	0.547920481432877	1554	Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation	ER-associated protein catabolic process|protein deglycosylation involved in glycoprotein catabolic process	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum
YLR412W	BER1	hom	FT	CYTOSKELETON	0.0103739393512508	0.547996588350618	1555	Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene	biological_process	molecular_function	cytoplasm
YFR005C	SAD1	het	FT	RNA PROCESSING|PROTEOLYSIS|NUCLEUS	0.0103553548658727	0.548713792241542	1556	Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle	mRNA splicing, via spliceosome	molecular_function	nucleus
YPL173W	MRPL40	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0103382750435367	0.549373337046947	1557	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDR339C	FCF1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0103367987866014	0.549430361695793	1558	Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus
YOR017W	PET127	hom	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0103277093268395	0.549781532357916	1559	Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane	mitochondrial RNA 5'-end processing	molecular_function	mitochondrial envelope|mitochondrion
YMR307W	GAS1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|GENE SILENCING|NUCLEUS|MITOCHONDRION|PLASMA MEMBRANE	0.0103251345231682	0.549881029815772	1560	Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery	fungal-type cell wall organization|chromatin silencing|filamentous growth	1,3-beta-glucanosyltransferase activity	mitochondrion|membrane raft|primary cell septum|nuclear periphery|integral to membrane|fungal-type cell wall|plasma membrane|cellular bud scar|ER to Golgi transport vesicle
YDR537C_d	YDR537C	hom			0.010313534137859	0.550329410396857	1561	Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W	Unknown	Unknown	Unknown
YKL174C	TPO5	hom	FT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0103065299440211	0.550600225097484	1562	Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles	polyamine transport	polyamine transmembrane transporter activity	integral to membrane|Golgi apparatus
YJL193W_p	YJL193W	hom			0.0102996375495058	0.551163899942704	1563	Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect	biological_process	molecular_function	integral to membrane
YLR140W_d	YLR140W	het			0.0102901014661414	0.551235683556866	1564	Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I	Unknown	Unknown	Unknown
YGR031W	IMO32	hom	FT	MITOCHONDRION	0.0102825412991456	0.551528234138777	1565	Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1	biological_process	molecular_function	mitochondrion
YDL033C	SLM3	hom	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.01027406068443	0.552212500270818	1566	tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)	mitochondrial tRNA thio-modification	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	mitochondrion
YKR007W	MEH1	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	0.0102564512807587	0.552834720434265	1567	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification	microautophagy|vacuolar acidification	molecular_function	fungal-type vacuole membrane|EGO complex|late endosome membrane
YBR015C	MNN2	hom	FF|FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0102154962779856	0.554125961471363	1568	Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment	protein glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YHL044W_p	YHL044W	hom	FT	PLASMA MEMBRANE	0.0101965542985642	0.554860970615202	1569	Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern	biological_process	molecular_function	plasma membrane
YLL012W	YEH1	hom	FT	LIPID METABOLISM	0.0101854973510432	0.555290235489498	1570	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes	sterol metabolic process	sterol esterase activity	integral to membrane|lipid particle
YDL051W	LHP1	hom	FT	RNA PROCESSING|NUCLEUS	0.0101788525235326	0.555548286214997	1571	RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen	tRNA processing	RNA binding|tRNA binding	nucleoplasm|nucleolus|nucleus
YBR189W	RPS9B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS|RIBOSOME	0.0101660590309828	0.556045284052741	1572	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication	positive regulation of translational fidelity|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YAL018C_p	YAL018C	hom			0.0101540917400079	0.556569235387956	1573	Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YMR316W	DIA1	hom			0.0101407084662627	0.557030735411186	1574	Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	pseudohyphal growth|invasive growth in response to glucose limitation	molecular_function	cytoplasm
YDR013W	PSF1	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0101302160667404	0.557438854663519	1575	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery	double-strand break repair via break-induced replication|DNA-dependent DNA replication	molecular_function	GINS complex|replication fork protection complex|DNA replication preinitiation complex
YMR265C_p	YMR265C	hom			0.0101123536544154	0.55813397728877	1576	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL119W	NCS2	hom	FT	RNA PROCESSING	0.0101064007465114	0.558894200790691	1577	Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	tRNA wobble position uridine thiolation|pseudohyphal growth|protein urmylation|invasive growth in response to glucose limitation	molecular_function	cytosol|cytoplasm
YOR087W	YVC1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.0100993393779537	0.558640698015027	1578	Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock	cellular cation homeostasis	voltage-gated ion channel activity|calcium activated cation channel activity|sodium channel activity|calcium channel activity|potassium channel activity	fungal-type vacuole membrane|fungal-type vacuole
YLR179C	YLR179C	hom	FT	NUCLEUS	0.0100922790107969	0.558915692217685	1579	Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YPL077C_p	YPL077C	hom			0.0100825789323228	0.559293607647493	1580	Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YKR020W	VPS51	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL DIVISION|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0100567059574528	0.560419200375955	1581	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p	vesicle organization|retrograde transport, endosome to Golgi|budding cell apical bud growth|regulation of cell size|protein targeting to vacuole	protein binding	Golgi apparatus|GARP complex
YOR345C_d	YOR345C	hom			0.0100502375977213	0.560554522239868	1582	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	Unknown	Unknown	Unknown
YNL336W	COS1	hom			0.0100146915065866	0.561941968608686	1583	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YDL198C	GGC1	hom	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.00999173389422675	0.563130207847051	1584	Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family	cellular iron ion homeostasis|mitochondrial genome maintenance|transmembrane transport|guanine nucleotide transport	guanine nucleotide transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YOR244W	ESA1	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.00998465744297484	0.563115559212031	1585	Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy	DNA repair|histone acetylation|regulation of cell cycle|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|chromatin silencing at rDNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	H4 histone acetyltransferase activity|histone acetyltransferase activity	Piccolo NuA4 histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YPL162C_p	YPL162C	hom			0.00997016872638103	0.563682132643398	1586	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YDL171C	GLT1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.00996587711243023	0.563850006582888	1587	NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source	glutamate biosynthetic process|ammonia assimilation cycle	glutamate synthase (NADH) activity	mitochondrion
YDL211C_p	YDL211C	hom			0.00995732829192634	0.564358805994442	1588	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	fungal-type vacuole
YLR454W_p	FMP27	hom	FT	MITOCHONDRION	0.00995523808869024	0.564266274277025	1589	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YMR073C	IRC21	hom	FF		0.00994931604975883	0.564962896596452	1590	Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study	response to drug	molecular_function	cytoplasm
YGR093W_p	YGR093W	hom	FT	NUCLEUS	0.00994878553641343	0.564518812045277	1591	Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	biological_process	molecular_function	nucleus
YDR242W	AMD2	hom			0.0099342291431046	0.565843704153462	1592	Putative amidase	biological_process	amidase activity	cellular_component
YBR179C	FZO1	hom	FT	MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00992248801124761	0.565722514946205	1593	Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system	mitochondrial fusion	GTPase activity|protein homodimerization activity	mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YPR084W_p	YPR084W	hom			0.00991482698852638	0.566312535216336	1594	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YCL055W	KAR4	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS	0.00991100969807067	0.566172142191726	1595	Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone	karyogamy involved in conjugation with cellular fusion|meiosis|negative regulation of transcription from RNA polymerase II promoter by pheromones|positive regulation of transcription from RNA polymerase II promoter by pheromones|G1 phase of mitotic cell cycle	sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YPR150W_d	YPR150W	hom			0.00990181710453589	0.566416562616406	1596	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C	Unknown	Unknown	Unknown
YDR411C	DFM1	hom	FT	SIGNALING|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX	0.00988034637022855	0.567258497087008	1597	Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p	endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process	molecular_function	Doa10p ubiquitin ligase complex|integral to membrane|endoplasmic reticulum|Hrd1p ubiquitin ligase ERAD-L complex
YLR315W	NKP2	hom	FT	CELL CYCLE|CELL DIVISION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.00985773217940282	0.568781443460196	1598	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2	biological_process	molecular_function	spindle pole body|kinetochore
YKL034W	TUL1	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00984741232798808	0.568493441215833	1599	Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein ubiquitination	ubiquitin-protein ligase activity	integral to membrane|Golgi apparatus
YGR149W_p	YGR149W	hom			0.00983459639626305	0.56899687738667	1600	Putative protein of unknown function; predicted to be an integal membrane protein	biological_process	molecular_function	integral to membrane
YER077C_p	YER077C	hom	FT	MITOCHONDRION	0.00983316077202934	0.569053284915654	1601	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport	biological_process	molecular_function	mitochondrion
YHR183W	GND1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.0098288770003119	0.569509691595826	1602	6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication	cellular response to oxidative stress|pentose-phosphate shunt, oxidative branch	phosphogluconate dehydrogenase (decarboxylating) activity	mitochondrion|cytoplasm
YPR118W	MRI1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.00982674440498359	0.569305424881799	1603	5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway	L-methionine salvage from methylthioadenosine	S-methyl-5-thioribose-1-phosphate isomerase activity	nucleus|cytoplasm
YJR002W	MPP10	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00981975137240126	0.569580286413793	1604	Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|Mpp10 complex|nucleolus|nucleus|90S preribosome
YGL034C_d	YGL034C	hom			0.00981095032943548	0.569926301828038	1605	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL202W	MRPL11	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.00980933585182973	0.569989786332377	1606	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOR335C	ALA1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00980538167502702	0.570145286747539	1607	Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog	alanyl-tRNA aminoacylation|mitochondrial alanyl-tRNA aminoacylation	alanine-tRNA ligase activity	mitochondrion|cytoplasm
YBL049W	MOH1	hom			0.0098028126584241	0.570246325725183	1608	Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase	biological_process	molecular_function	cellular_component
YKR047W_d	YKR047W	hom			0.00978941928423615	0.570773222939662	1609	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1	Unknown	Unknown	Unknown
YJR147W	HMS2	hom	FT	NUCLEUS	0.00977217798139585	0.571451839201182	1610	Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication	pseudohyphal growth	molecular_function	nucleus|cytoplasm
YHR184W	SSP1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION	0.00976778662000771	0.571682093550681	1611	Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis	ascospore wall assembly|protein complex assembly	molecular_function	prospore membrane
YPR195C_d	YPR195C	hom			0.00976503323020034	0.571733168406978	1612	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL245W_p	YPL245W	hom	FT	NUCLEUS	0.00975740253113436	0.572033704797024	1613	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YOL163W_p	YOL163W	hom			0.00972523498464223	0.573301453397951	1614	Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family	transmembrane transport	transmembrane transporter activity	integral to membrane|membrane
YDR022C	ATG31	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|CHROMOSOME SEGREGATION|CYTOSKELETON	0.00970724045272941	0.574011212605544	1615	Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion	autophagy|mitochondrion degradation|piecemeal microautophagy of nucleus	molecular_function	pre-autophagosomal structure|cytoplasm
YPL192C	PRM3	hom	FT	MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON	0.00968731036129329	0.574797801380794	1616	Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body	karyogamy involved in conjugation with cellular fusion|nuclear membrane fusion involved in karyogamy	molecular_function	nuclear envelope|spindle pole body|extrinsic to nuclear outer membrane
YNL006W	LST8	het	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE	0.00967524463771667	0.575274251577421	1617	Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat	transport|TOR signaling cascade|fungal-type cell wall organization|signal transduction|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity|mitochondria-nucleus signaling pathway	protein kinase activator activity|protein binding	TORC1 complex|TORC2 complex|endosome membrane|extrinsic to internal side of plasma membrane|Golgi membrane
YBR258C	SHG1	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS	0.0096659179085831	0.575642672414084	1618	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres	histone H3-K4 methylation	histone methyltransferase activity (H3-K4 specific)	nucleus|Set1C/COMPASS complex
YHL024W	RIM4	hom	FT	CELL CYCLE	0.0096643913539967	0.575702984388233	1619	Putative RNA-binding protein required for the expression of early and middle sporulation genes	meiosis|reciprocal meiotic recombination|sporulation resulting in formation of a cellular spore|premeiotic DNA replication	RNA binding	cytoplasm
YKR003W	OSH6	hom	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.00965200115426533	0.576192613673699	1620	Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion	sterol homeostasis|maintenance of cell polarity|endocytosis|sterol transport|exocytosis|sterol metabolic process	phosphatidic acid binding|lipid binding|phosphatidylinositol-3,4-bisphosphate binding|oxysterol binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-4-phosphate binding	cortical endoplasmic reticulum|extrinsic to membrane|cytoplasm
YJR142W_p	YJR142W	hom			0.00964473144317543	0.576479985630779	1621	Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member	biological_process	molecular_function	cellular_component
YFL051C_p	YFL051C	hom	FT	PLASMA MEMBRANE	0.00963309700152778	0.576940036106648	1622	Putative protein of unknown function; YFL051C is not an essential gene	biological_process	molecular_function	cellular_component
YPR201W	ARR3	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0096327894101906	0.576952201266242	1623	Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite	arsenite transport|antimonite transport	antiporter activity|arsenite transmembrane transporter activity|antimonite transmembrane transporter activity	integral to membrane|plasma membrane
YDR330W	UBX5	hom	FT	PROTEOLYSIS|NUCLEUS	0.00960932148432816	0.578107615274048	1624	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p	proteasomal ubiquitin-dependent protein catabolic process	molecular_function	nucleus|cytoplasm
YCL057C-A	MOS1	hom	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00959721963456884	0.578359791128309	1625	Mitochondrial protein essential for proper inner membrane organization; conserved component of the mitochondrial inner membrane organizing system (MICOS, MINOS, or MitOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture; ortholog of human MINOS1	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YDR273W	DON1	hom	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION	0.00959139739216803	0.578760290720756	1626	Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II	meiosis|ascospore wall assembly	molecular_function	prospore membrane
YLR167W	RPS31	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION|NUCLEUS|RIBOSOME	0.00959134412803056	0.578592455637588	1627	Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)|ribosomal small subunit assembly|ribosome biogenesis	structural constituent of ribosome|protein tag	cytosolic small ribosomal subunit|cytoplasm
YPL249C-A	RPL36B	hom	FT	TRANSLATION|RIBOSOME	0.00958544284209146	0.578826185234693	1628	Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YLR060W	FRS1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.00958227921291379	0.578951503934962	1629	Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control	phenylalanyl-tRNA aminoacylation	phenylalanine-tRNA ligase activity	phenylalanine-tRNA ligase complex|cytoplasm
YKL072W	STB6	hom			0.00956414823719031	0.579669959564898	1630	Protein that binds Sin3p in a two-hybrid assay	biological_process	molecular_function	cellular_component
YNR012W	URK1	hom	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.00955696008917492	0.579954911837694	1631	Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP	pyrimidine-containing compound salvage	uridine kinase activity	nucleus|cytoplasm
YPR010C	RPA135	het	FT	NUCLEUS	0.00954926634271067	0.580259979739637	1632	RNA polymerase I second largest subunit A135	transcription of nuclear large rRNA transcript from RNA polymerase I promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase I complex
YML023C	NSE5	het	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.00954689696968548	0.58041039873782	1633	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair	DNA repair	molecular_function	Smc5-Smc6 complex|nucleus
YOR301W	RAX1	hom	FT	CELL CYCLE|SIGNALING|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.00954256268066999	0.580525850660948	1634	Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily	cellular bud site selection	molecular_function	integral to membrane|cellular bud neck
YOR339C	UBC11	hom			0.00954005050427698	0.580625499647259	1635	Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2	protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YDR481C	PHO8	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.00953914214968912	0.580661532771945	1636	Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN	nicotinamide nucleotide metabolic process|protein dephosphorylation	nucleotide phosphatase activity|alkaline phosphatase activity	fungal-type vacuole membrane
YLL052C	AQY2	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.00952273440769506	0.581312584522289	1637	Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains	water transport	water channel activity	plasma membrane|endoplasmic reticulum membrane
YMR086C-A_d	YMR086C-A	hom			0.00952269393655611	0.581314190820586	1638	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL133W	MRS3	hom	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.00951899321941369	0.581461080943684	1639	Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication	mitochondrial iron ion transport|RNA splicing	iron ion transmembrane transporter activity	mitochondrion|integral to membrane
YIL124W	AYR1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.00951404782036235	0.581713722197078	1640	NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones	phosphatidic acid biosynthetic process	acylglycerone-phosphate reductase activity	mitochondrial outer membrane|mitochondrion|integral to membrane|endoplasmic reticulum|lipid particle|cytoplasm
YEL013W	VAC8	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.00949896250983308	0.582256447621704	1641	Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions	piecemeal microautophagy of nucleus|vacuole inheritance|CVT vesicle assembly|vacuole fusion, non-autophagic|macroautophagy|nucleus-vacuole junction assembly	protein anchor	fungal-type vacuole membrane|nucleus-vacuole junction|Myo2p-Vac17p-Vac8p transport complex
YJL064W_d	YJL064W	hom			0.00949336841532225	0.582478665055646	1642	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1	Unknown	Unknown	Unknown
YPR164W	MMS1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.00949260717603137	0.58250890726052	1643	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay	replication fork processing|negative regulation of transposition, RNA-mediated|recombinational repair|nonfunctional rRNA decay	molecular_function	Cul8-RING ubiquitin ligase complex
YGL021W	ALK1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	0.00949070799292864	0.582978153271351	1644	Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins	mitosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YPL087W	YDC1	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.00946942312757681	0.583430304431046	1645	Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication	ceramide catabolic process|ceramide biosynthetic process	dihydroceramidase activity	integral to membrane|endoplasmic reticulum
YJL124C	LSM1	hom	FF|FT	RNA PROCESSING|NUCLEUS	0.00944221752999027	0.585016985148676	1646	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	RNA binding|RNA cap binding	mRNA cap binding complex|cytoplasmic mRNA processing body|cytoplasm
YCR105W	ADH7	hom	FT	OXIDATION-REDUCTION PROCESS	0.00943039467956367	0.584982932745318	1647	NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance	alcohol metabolic process	alcohol dehydrogenase (NADP+) activity	cellular_component
YAR047C_d	YAR047C	hom			0.00942499810733532	0.585197769962297	1648	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL027W	VMA3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	0.00942060036942647	0.585540699812855	1649	Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis	cellular copper ion homeostasis|cellular iron ion homeostasis|endocytosis|vacuole organization|proton transport|vacuolar acidification|protein targeting to vacuole	hydrogen ion transmembrane transporter activity	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YOL026C	MIM1	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00939542610623858	0.586375679563435	1650	Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex	mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane	molecular_function	mitochondrial outer membrane|integral to mitochondrial outer membrane
YKL069W	YKL069W	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.00939431016244813	0.586475973633381	1651	Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress	cellular response to oxidative stress	methionine-R-sulfoxide reductase activity	nucleus|cytoplasm
YDL045C	FAD1	het	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.00937841944302526	0.587053584907406	1652	Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin	FAD biosynthetic process	FMN adenylyltransferase activity	cytoplasm
YML073C	RPL6A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.00937488175820188	0.587417675288883	1653	Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YHL040C	ARN1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.00936442827030754	0.587611561146658	1654	ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress	siderophore transport	siderophore transmembrane transporter activity	endosome|integral to membrane|plasma membrane|cytoplasmic membrane-bounded vesicle
YDL009C_p	YDL009C	hom			0.00935989171468802	0.587792534304986	1655	Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene	biological_process	molecular_function	cellular_component
YPR089W_p	YPR089W	hom	FT	GOLGI APPARATUS	0.00933481090085657	0.588793527696025	1656	Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p	biological_process	molecular_function	cellular_component
YMR068W	AVO2	hom	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE	0.00932842443102363	0.589048541922555	1657	Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth	fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity	molecular_function	TORC2 complex|cytoplasm
YDL053C	PBP4	hom	FT	NUCLEUS	0.00932377099628755	0.589234387462347	1658	Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasmic stress granule|cytoplasm
YFR012W-A_p	YFR012W-A	hom			0.00930742678761443	0.589942801859099	1659	Putative protein of unknown function; identified by homology	biological_process	molecular_function	cellular_component
YHR010W	RPL27A	hom	FT	TRANSLATION|RIBOSOME	0.00930249274309547	0.590084527349351	1660	Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YHR082C	KSP1	hom	FT	PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.00928839547125872	0.590648073001135	1661	Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress	TOR signaling cascade|protein phosphorylation|Unknown|cellular protein localization|regulation of filamentous growth|negative regulation of macroautophagy	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YDL002C	NHP10	hom	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.00928642884002377	0.590726709762658	1662	Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair	double-strand break repair|nucleosome mobilization	DNA end binding|loop DNA binding	nucleus|Ino80 complex
YBR062C_p	YBR062C	hom			0.00927080579554306	0.591572847171583	1663	Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.	biological_process	molecular_function	cellular_component
YML105C	SEC65	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS	0.00925266753781611	0.592353652486755	1664	Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER	7S RNA binding	signal recognition particle, endoplasmic reticulum targeting
YDL070W	BDF2	hom	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS	0.0092512586820341	0.592354757277926	1665	Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress	negative regulation of heterochromatin assembly	histone acetyl-lysine binding|core promoter binding|histone binding|TFIID-class transcription factor binding	nucleus
YOR293C-A_p	YOR293C-A	hom			0.00924276611681788	0.592473824915345	1666	Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YJL189W	RPL39	hom	FT	TRANSLATION|RIBOSOME	0.00924108610711591	0.592541095933992	1667	Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOR365C_p	YOR365C	hom			0.00924032611770091	0.592626700752368	1668	Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YER079W_p	YER079W	hom	FT	NUCLEUS	0.00923640609866793	0.592728511487773	1669	Putative protein of unknown function	biological_process	molecular_function	nucleus|cytoplasm
YJR093C	FIP1	het	FT	RNA PROCESSING|NUCLEUS	0.00922589896561562	0.593149378916635	1670	Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p	mRNA cleavage|mRNA polyadenylation	RNA binding|protein binding, bridging	mRNA cleavage and polyadenylation specificity factor complex
YDL233W_p	MFG1	hom	FT	NUCLEUS	0.00920587589376689	0.59395178971207	1671	Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YFR034C	PHO4	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.00919748294009065	0.594508298706303	1672	Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability	cellular response to phosphate starvation|positive regulation of phosphate metabolic process|phosphate-containing compound metabolic process|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YPR095C	SYT1	hom	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|MITOCHONDRION|GOLGI APPARATUS	0.00918257875798847	0.594886030573798	1673	Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain	vesicle-mediated transport|exocytosis|positive regulation of ARF protein signal transduction	ARF guanyl-nucleotide exchange factor activity	mitochondrion|Golgi apparatus part
YIL084C	SDS3	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.00912203840161697	0.597535617230519	1674	Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|chromatin silencing|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation	histone deacetylase activity	Rpd3L-Expanded complex|Rpd3L complex
YML079W_p	YML079W	hom	FT	NUCLEUS	0.00910216848486114	0.600362012007686	1675	Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YOR029W_d	YOR029W	hom			0.00909176289969611	0.598534234045156	1676	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL049W	GSH2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.00905339606588625	0.600132894226362	1677	Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock	glutathione biosynthetic process	glutathione synthase activity	intracellular
YBR031W	RPL4A	hom	FT	TRANSLATION|RIBOSOME	0.00904884035420565	0.600262017805809	1678	Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDL008W	APC11	het	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0090402400914759	0.600608479653027	1679	Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YFR053C	HXK1	hom	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.00903860414395762	0.600674394074234	1680	Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication	mannose metabolic process|glucose import|glycolysis|fructose import|glucose metabolic process|fructose metabolic process	hexokinase activity	cytosol|mitochondrion|cytoplasm
YCR043C_p	YCR043C	hom	FT	GOLGI APPARATUS|SITE OF POLARIZED GROWTH	0.00902627246153966	0.601171358468327	1681	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene	biological_process	molecular_function	Golgi apparatus|mating projection tip
YNL276C_d	YNL276C	hom			0.00902557396801911	0.601199513172855	1682	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W	Unknown	Unknown	Unknown
YLR203C	MSS51	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00902109005309877	0.601380263877862	1683	Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	extrinsic to mitochondrial inner membrane|mitochondrion
YIR043C	YIR043C	hom			0.0090070187227297	0.601947651169243	1684	Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family	biological_process	molecular_function	cellular_component
YMR090W_p	YMR090W	hom			0.00900624905372124	0.601978692890461	1685	Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability	biological_process	molecular_function	cytoplasm
YNL220W	ADE12	hom	FT	NUCLEOTIDE METABOLISM	0.00900356921995212	0.602086779591931	1686	Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence	purine nucleotide biosynthetic process	DNA replication origin binding|adenylosuccinate synthase activity	cytoplasm
YGL168W	HUR1	hom	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	0.00898090862389317	0.603001106928726	1687	Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene	DNA replication	molecular_function	cellular_component
YDR324C	UTP4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00897979168896172	0.603046190032844	1688	Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript	positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus|t-UTP complex|90S preribosome
YBL065W_d	YBL065W	hom			0.00895920859647239	0.605717467399081	1689	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene	Unknown	Unknown	Unknown
YNL042W-B_p	YNL042W-B	hom			0.00895368948822357	0.60410019057108	1690	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR004C	GPI18	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.00894195377210422	0.604574345252365	1691	Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria	GPI anchor biosynthetic process	mannosyltransferase activity|dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity	integral to endoplasmic reticulum membrane|mitochondrion|mannosyltransferase complex|integral to membrane|endoplasmic reticulum
YIL062C	ARC15	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|MITOCHONDRION|CYTOSKELETON	0.00894174714827598	0.604582694909007	1692	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity	mitochondrion inheritance|actin cortical patch assembly	mRNA binding|structural molecule activity	Arp2/3 protein complex|extrinsic to mitochondrial outer membrane
YJR015W_p	YJR015W	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.008939403628188	0.60467740003608	1693	Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum|cytoplasm
YGL262W_p	YGL262W	hom			0.00893737617968759	0.604759337607128	1694	Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene	biological_process	molecular_function	cellular_component
YDR021W	FAL1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00891019030128737	0.605858511778829	1695	Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus|FAl1-SGD1 complex
YHL043W	ECM34	hom	FT	CELL WALL ORG/BIOGENESIS	0.00890306528086097	0.606146736983591	1696	Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	fungal-type cell wall organization	molecular_function	cellular_component
YOL122C	SMF1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.00889995665984607	0.606272507821218	1697	Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins	copper ion transport|cellular copper ion homeostasis|manganese ion transport|cadmium ion transport|cellular manganese ion homeostasis|cellular cadmium ion homeostasis|iron ion transport	solute:hydrogen symporter activity|inorganic cation transmembrane transporter activity	integral to membrane|plasma membrane
YDR414C	ERD1	hom	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00888175824678539	0.607009026320678	1698	Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)	protein retention in ER lumen|protein glycosylation	molecular_function	integral to membrane|membrane
YHL006C	SHU1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.00887630234117067	0.607229913236628	1699	Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function	recombinational repair|maintenance of rDNA	molecular_function	nucleolus|Shu complex
YJR025C	BNA1	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.00887513286495326	0.607598912435662	1700	3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p	de novo NAD biosynthetic process from tryptophan	3-hydroxyanthranilate 3,4-dioxygenase activity	cytoplasm
YOL018C	TLG2	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.00887453301575789	0.608213789468535	1701	Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)	inositolphosphoceramide metabolic process|Golgi to vacuole transport|endocytosis|mannosyl-inositol phosphorylceramide metabolic process|protein exit from endoplasmic reticulum|vesicle fusion|CVT pathway	SNAP receptor activity	SNARE complex|trans-Golgi network|integral to endosome membrane
YLR227C	ADY4	hom	FT	CELL CYCLE|CELL DIVISION|NUCLEUS|CYTOSKELETON	0.00884912370158795	0.608384264127529	1702	Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane	sporulation resulting in formation of a cellular spore	structural molecule activity	spindle pole body
YDR427W	RPN9	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	0.00884870751323027	0.608347662058097	1703	Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress	proteasome assembly|ubiquitin-dependent protein catabolic process	structural molecule activity	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YLR401C	DUS3	hom	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS|NUCLEUS	0.00884757619066458	0.608393506657846	1704	Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress	tRNA modification	tRNA dihydrouridine synthase activity	nucleus|cytoplasm
YMR210W	YMR210W	hom	FT	KETONE METABOLISM|LIPID METABOLISM	0.00878747961356679	0.610831008703878	1705	Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification	medium-chain fatty acid biosynthetic process	transferase activity, transferring acyl groups	cellular_component
YER149C	PEA2	hom	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.00878491437570564	0.610935150374499	1706	Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth	bipolar cellular bud site selection|regulation of initiation of mating projection growth|regulation of termination of mating projection growth|actin filament organization|pseudohyphal growth|establishment of cell polarity|filamentous growth|Rho protein signal transduction	cytoskeletal regulatory protein binding	polarisome|actin cap|mating projection tip
YIL077C_p	YIL077C	hom	FT	MITOCHONDRION	0.00878110834011725	0.611089679549282	1707	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	biological_process	molecular_function	mitochondrion
YDR089W	YDR089W	hom	FT	MEMBRANE ORGANIZATION	0.00877828964225609	0.611363612955079	1708	Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress	cellular membrane organization	molecular_function	integral to membrane|membrane
YDR387C_p	YDR387C	hom			0.00877198903090487	0.611460003828617	1709	Putative transporter, member of the sugar porter family; YDR387C is not an essential gene	transport|transmembrane transport	substrate-specific transmembrane transporter activity	integral to membrane|membrane
YLL009C	COX17	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.00877141714087349	0.611483230911639	1710	Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex IV assembly|intracellular copper ion transport	copper chaperone activity	cytosol|mitochondrion|mitochondrial intermembrane space
YKL030W_d	YKL030W	hom			0.00876359415296862	0.611800997617706	1711	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene MAE1	Unknown	Unknown	Unknown
YKL126W	YPK1	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.00876255099925288	0.612002643424657	1712	Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication	eisosome assembly|protein autophosphorylation|negative regulation of phospholipid translocation|protein phosphorylation	protein serine/threonine kinase activity	cytosol|plasma membrane|cellular bud neck
YDL229W	SSB1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS	0.00876249862053412	0.611845503547745	1713	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication	cytoplasmic translation|cellular response to glucose starvation|translational termination|ribosomal subunit export from nucleus|regulation of translational fidelity|rRNA processing|'de novo' cotranslational protein folding	unfolded protein binding|ATPase activity|calmodulin binding	plasma membrane|polysome|cytoplasm
YLR432W	IMD3	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM	0.00875328575066803	0.612219832407223	1714	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed	GTP biosynthetic process	IMP dehydrogenase activity	plasma membrane|cytoplasm
YFL047W	RGD2	hom	FT	SIGNALING|SITE OF POLARIZED GROWTH	0.00871761345420407	0.613670190267236	1715	GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress	small GTPase mediated signal transduction	Rho GTPase activator activity	cellular bud neck|cytoplasm
YHR129C	ARP1	hom	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0087126806216988	0.613870867651012	1716	Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin	nuclear migration|establishment of mitotic spindle orientation	structural constituent of cytoskeleton	cell cortex|dynactin complex|spindle pole body|astral microtubule
YLR120C	YPS1	hom	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS|PLASMA MEMBRANE	0.00871258814687953	0.613874629985727	1717	Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	fungal-type cell wall organization|protein processing	aspartic-type endopeptidase activity	fungal-type cell wall
YBR276C	PPS1	hom	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|NUCLEUS	0.00870227498124439	0.614294284502331	1718	Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle	inactivation of MAPK activity|protein dephosphorylation|regulation of S phase of mitotic cell cycle	protein tyrosine/serine/threonine phosphatase activity	cellular_component
YML109W	ZDS2	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|GENE SILENCING|NUCLEUS|SITE OF POLARIZED GROWTH	0.00870056697099266	0.614363797586146	1719	Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication	positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|establishment of cell polarity|regulation of protein localization|chromatin silencing at rDNA|cell aging	molecular_function	nucleus|cellular bud neck|cellular bud tip|cytoplasm
YGR204W	ADE3	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.00869193672487968	0.614715086725997	1720	Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine	purine nucleobase biosynthetic process|folic acid-containing compound metabolic process	methylenetetrahydrofolate dehydrogenase (NADP+) activity|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity	nucleus|cytoplasm
YEL020C_p	YEL020C	hom			0.00868376158672905	0.615047932444719	1721	Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cytoplasm
YPL249C	GYP5	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.00867532240462359	0.615602411070296	1722	GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress	vesicle-mediated transport|ER to Golgi vesicle-mediated transport	Rab GTPase activator activity	cytosol|incipient cellular bud site|plasma membrane|cellular bud neck|Golgi-associated vesicle|cellular bud tip
YJR073C	OPI3	hom	FF|FT	LIPID METABOLISM|MITOCHONDRION	0.00867331283174403	0.615736940643921	1723	Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis	phosphatidylcholine biosynthetic process	phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|phosphatidyl-N-methylethanolamine N-methyltransferase activity	mitochondrion|integral to membrane
YBL080C	PET112	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00866796721411368	0.6156912149323	1724	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog	glutaminyl-tRNAGln biosynthesis via transamidation|mitochondrial translation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YDL054C	MCH1	hom			0.00866511768040918	0.615859942599418	1725	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|membrane
YDR053W_d	YDR053W	het			0.00866019473703492	0.616007885384001	1726	Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex	Unknown	Unknown	Unknown
YLR405W	DUS4	hom	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	0.00864690696506063	0.616759710771917	1727	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p	tRNA modification	tRNA dihydrouridine synthase activity	cellular_component
YML063W	RPS1B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.00862800624894637	0.617320086379845	1728	Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YBR134W_d	YBR134W	hom			0.00860980020098853	0.618062818379736	1729	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML057C-A_d	YML057C-A	hom			0.0085872034589017	0.618985215558889	1730	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W	Unknown	Unknown	Unknown
YFL028C	CAF16	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM|NUCLEUS	0.00858130165732317	0.619226225519261	1731	Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator	regulation of transcription from RNA polymerase II promoter	ATPase activity	CCR4-NOT complex|cytoplasm
YNL064C	YDJ1	hom	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	0.00852550689325774	0.621506717371323	1732	Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family	protein refolding|ER-associated protein catabolic process|protein targeting to mitochondrion|protein targeting to ER|'de novo' protein folding	unfolded protein binding|ATPase activator activity	cytosol|TRC complex|perinuclear region of cytoplasm
YDR507C	GIN4	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH	0.00851380198957566	0.621985592744031	1733	Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication	protein autophosphorylation|budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly	protein kinase activity	cellular bud neck
YMR006C	PLB2	hom	FT	LIPID METABOLISM	0.00851349189052482	0.621998281808073	1734	Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine	glycerophospholipid metabolic process	lysophospholipase activity	extracellular region|fungal-type cell wall
YJL127C	SPT10	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS	0.00850555709706797	0.622323006908674	1735	Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box	DNA repair|negative regulation of transcription from RNA polymerase II promoter|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	histone acetyltransferase activity|sequence-specific DNA binding	nucleus
YKR095W	MLP1	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON	0.00850208327414844	0.622465193471949	1736	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs	protein localization to nuclear pore|poly(A)+ mRNA export from nucleus|protein import into nucleus|transcriptional activation by promoter-terminator looping|nuclear retention of unspliced pre-mRNA at the site of transcription|telomere tethering at nuclear periphery	ribonucleoprotein complex binding	nucleoplasm|nuclear envelope|integral to membrane|ribonucleoprotein complex|spindle pole body
YIL029C_p	YIL029C	hom			0.00846055108109934	0.624166230992567	1737	Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W	biological_process	molecular_function	integral to membrane
YER127W	LCP5	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00845681277107237	0.62431943973286	1738	Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus	rRNA modification|rRNA processing	RNA binding	small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex
YDR152W	GIR2	hom	FT	TRANSLATION	0.00845497338878191	0.624549877099239	1739	Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein	cytoplasmic translation	molecular_function	polysome|cytoplasm
YOR025W	HST3	hom	FT	KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS	0.00845027022079791	0.624587614910339	1740	Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism	short-chain fatty acid metabolic process|histone deacetylation|chromatin silencing at telomere	histone deacetylase activity|DNA binding	nucleus
YJR107W_p	YJR107W	hom	FT	LIPID METABOLISM	0.0084265996136226	0.625558273798053	1741	Putative lipase	biological_process	lipase activity	cellular_component
YCR022C_d	YCR022C	hom			0.0084189626512123	0.625871580759328	1742	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene	Unknown	Unknown	Unknown
YAL028W	FRT2	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00841646481988185	0.625974069137857	1743	Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication	response to stress	molecular_function	endoplasmic reticulum
YKL172W	EBP2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00838312192769928	0.627496892207568	1744	Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering	nuclear division|rRNA processing	molecular_function	nuclear periphery|nucleolus|preribosome, large subunit precursor
YER065C	ICL1	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	0.00836628349885102	0.628034584104779	1745	Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose	glyoxylate cycle	isocitrate lyase activity	cellular_component
YCL054W	SPB1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00835470407569078	0.62856166844214	1746	AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA methylation	rRNA (uridine-2'-O-)-methyltransferase activity|rRNA (guanine) methyltransferase activity	nucleolus|nucleus|preribosome, large subunit precursor
YLR050C_p	YLR050C	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00834599203739548	0.628868604507694	1747	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YKR068C	BET3	het	FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.00832804331940049	0.629606728160178	1748	Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport	Rab guanyl-nucleotide exchange factor activity	TRAPP complex|cis-Golgi network membrane
YOL033W	MSE1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00832118982555355	0.629888669094405	1749	Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated	mitochondrial glutamyl-tRNA aminoacylation|glutamyl-tRNA aminoacylation|mitochondrial translation	glutamate-tRNA(Gln) ligase activity|glutamate-tRNA ligase activity	mitochondrion
YLR335W	NUP2	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CHROMOSOME|NUCLEAR PORE	0.00831729182383765	0.630100078785275	1750	Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization	rRNA export from nucleus|snRNA export from nucleus|nuclear pore organization|tRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA-binding (hnRNP) protein import into nucleus|ribosomal protein import into nucleus|snRNP protein import into nucleus|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|protein targeting to membrane|poly(A)+ mRNA export from nucleus|protein export from nucleus|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, non-stop decay	nucleocytoplasmic transporter activity	nuclear chromatin|mitochondrion|integral to membrane|nuclear pore
YLR233C	EST1	hom	FT	NUCLEUS|CHROMOSOME	0.00830907482435564	0.63038719122487	1751	TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA	telomere maintenance via telomerase|telomere maintenance|G-quadruplex DNA formation	single-stranded DNA binding|RNA binding|telomeric DNA binding	nucleolus|nucleus|telomerase holoenzyme complex
YAR002C-A	ERP1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.00828368455362269	0.63168696816572	1752	Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport	molecular_function	mitochondrion|ER to Golgi transport vesicle
YDL219W	DTD1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.00825056862505172	0.632797037077466	1753	D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes	Unknown	D-leucyl-tRNA(Leu) deacylase activity|D-tyrosyl-tRNA(Tyr) deacylase activity	cytoplasm
YOL048C	RRT8	hom			0.00824683489458535	0.632950960574582	1754	Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|lipid particle
YJR054W	KCH1	hom			0.00824420937646749	0.633059207396552	1755	Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YKR013W	PRY2	hom			0.0082386384590515	0.633288915353101	1756	Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication	biological_process	molecular_function	extracellular region|fungal-type vacuole
YKL140W	TGL1	hom	FT	LIPID METABOLISM	0.00823662804637158	0.633371820215926	1757	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes	cellular lipid metabolic process|sterol metabolic process	lipase activity|sterol esterase activity	integral to membrane|lipid particle
YLR241W_p	YLR241W	hom			0.00822751006656311	0.633798486376921	1758	Putative protein of unknown function, may be involved in detoxification	biological_process	molecular_function	integral to membrane
YJL098W	SAP185	hom	FT	CELL CYCLE|RNA PROCESSING|MITOCHONDRION	0.00821961025570975	0.634073779607196	1759	Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication	tRNA wobble uridine modification|G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	mitochondrion|cytoplasm
YNL281W	HCH1	hom	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.00821149300664822	0.634408720461972	1760	Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress	protein folding|response to stress	ATPase activator activity|chaperone binding	nucleus|cytoplasm
YDR200C	VPS64	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0082112334463584	0.634419431895311	1761	Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance	re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole	molecular_function	endoplasmic reticulum membrane|cytoplasm
YDR423C	CAD1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.00820521992315779	0.634667617059425	1762	AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication	cellular response to cadmium ion|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YHR134W	WSS1	hom	FT	RESPONSE TO DNA DAMAGE|ENDOMEMBRANE SYSTEM|NUCLEUS	0.00819770552329203	0.634977802866681	1763	Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response	protein sumoylation|response to UV-B|response to UV-C|response to DNA damage stimulus	molecular_function	nuclear envelope
YAL059W	ECM1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|CELL WALL ORG/BIOGENESIS|NUCLEUS	0.00816305270853875	0.636409059463161	1764	Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm	fungal-type cell wall organization|ribosomal large subunit export from nucleus	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YJL171C	YJL171C	hom	FT	MITOCHONDRION|PLASMA MEMBRANE	0.00816044180639075	0.636516951968565	1765	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrion|fungal-type cell wall|plasma membrane
YBL097W	BRN1	het	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.00815546531106531	0.636722621211552	1766	Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission	mitotic chromosome condensation|tRNA gene clustering|mitotic sister chromatid segregation	molecular_function	nucleus|SMC loading complex|nuclear condensin complex
YGL096W	TOS8	hom	FT	NUCLEUS|CHROMOSOME	0.00815233607721371	0.636851960924431	1767	Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication	biological_process	chromatin binding|sequence-specific DNA binding	nuclear chromatin
YNL211C_p	YNL211C	hom	FT	MITOCHONDRION	0.00814368917474725	0.637209418331973	1768	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene	biological_process	molecular_function	mitochondrion
YER097W_d	YER097W	hom			0.00812730730802198	0.637886865537422	1769	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR134W	MSS18	hom	FT	RNA PROCESSING|MITOCHONDRION	0.00812161642806693	0.638172371494868	1770	Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions	Group I intron splicing	molecular_function	mitochondrion
YKL080W	VMA5	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.00811424930410291	0.638427076076553	1771	Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YDR085C	AFR1	hom	FT	SIGNALING	0.00810048785990123	0.638996595680915	1772	Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication	regulation of G-protein coupled receptor protein signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation	receptor signaling protein activity	mating projection base
YDR296W	MHR1	hom	FT	MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|MITOCHONDRION	0.00809806221644228	0.639097003404221	1773	Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress	cellular response to oxidative stress|positive regulation of mitochondrial DNA replication|regulation of transcription, DNA-dependent|mitochondrial genome maintenance|DNA recombination	single-stranded DNA binding|recombinase activity|DNA binding	mitochondrion|nucleus
YLR334C_d	YLR334C	hom			0.00809729832398981	0.639128625538364	1774	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here	Unknown	Unknown	Unknown
YKL088W	CAB3	het	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.00808971115591394	0.639442739957327	1775	Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC	response to salt stress|coenzyme A biosynthetic process	phosphopantothenoylcysteine decarboxylase activity|purine nucleotide binding	phosphopantothenoylcysteine decarboxylase complex|cytoplasm
YDR412W	RRP17	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00807849620861501	0.639907165512705	1776	Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5&#8242; end processing of pre-60S ribosomal RNA	rRNA processing	molecular_function	cytoplasm
YCR102W-A_d	YCR102W-A	hom			0.00806915957337961	0.640293915339033	1777	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL067C	COX9	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.00805657705769556	0.640815273224785	1778	Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YDR093W	DNF2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.00803261633968087	0.641808577969283	1779	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase	intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity	phospholipid-translocating ATPase activity	integral to membrane|plasma membrane
YMR069W	NAT4	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS	0.00802094593062436	0.642739440720754	1780	N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A	histone acetylation	histone acetyltransferase activity	nucleus|cytoplasm
YBL088C	TEL1	hom	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.00801977281684545	0.642539754318183	1781	Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)	double-strand break repair|histone phosphorylation|telomere maintenance|response to DNA damage stimulus|phosphorylation|DNA damage induced protein phosphorylation	protein kinase activity|telomeric DNA binding	mitochondrion|nucleus
YDR360W_d	OPI7	hom			0.00801472737414883	0.64255059294108	1782	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.	Unknown	Unknown	Unknown
YOR117W	RPT5	het	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS	0.00800754318544632	0.643245308541057	1783	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	ATPase activity	proteasome regulatory particle, base subcomplex
YKR098C	UBP11	hom	FT	PROTEOLYSIS	0.00797703915744375	0.644115026128088	1784	Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins	biological_process	ubiquitin-specific protease activity	cellular_component
YNL032W	SIW14	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	0.0079729731888897	0.644283898352052	1785	Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm	actin filament organization|endocytosis|protein dephosphorylation|response to stress	protein tyrosine phosphatase activity	cytoplasm
YGL061C	DUO1	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.00795819453575754	0.644947162092181	1786	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis	mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization	microtubule binding|structural constituent of cytoskeleton	spindle microtubule|DASH complex|condensed nuclear chromosome kinetochore|spindle pole body|spindle
YOR250C	CLP1	het	FT	RNA PROCESSING|NUCLEUS	0.00793969115525745	0.645666893221441	1787	Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation	mRNA 3'-end processing|mRNA cleavage|mRNA polyadenylation	RNA binding	mRNA cleavage factor complex
YJL031C	BET4	het	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN PRENYLATION	0.00793193194738269	0.646481672349591	1788	Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p	protein targeting to membrane|protein geranylgeranylation|ER to Golgi vesicle-mediated transport	Rab geranylgeranyltransferase activity	Rab-protein geranylgeranyltransferase complex
YNR029C_p	YNR029C	hom			0.0078836559876537	0.647998133989362	1789	Putative protein of unknown function, deletion confers reduced fitness in saline	biological_process	molecular_function	cytoplasm
YLR216C	CPR6	hom			0.00787419938023978	0.648391900115006	1790	Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress	protein folding|protein refolding	unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity	cytoplasm
YMR150C	IMP1	hom	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00786975842108519	0.648576852291181	1791	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	protein processing involved in protein targeting to mitochondrion	endopeptidase activity	mitochondrion|mitochondrial inner membrane peptidase complex
YDR286C_p	YDR286C	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.00786788408059618	0.64865491926326	1792	Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site	biological_process	molecular_function	cellular_component
YMR044W	IOC4	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS	0.00786357227207245	0.649078821866263	1793	Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing	chromatin remodeling	nucleosome binding|ATPase activity|DNA binding	ISW1 complex
YPL108W_p	YPL108W	hom			0.00785671945260265	0.649168818627874	1794	Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cytoplasm
YOL086W-A	MHF1	hom	FT	RESPONSE TO DNA DAMAGE	0.00785341478961309	0.649257700402363	1795	Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1	response to DNA damage stimulus	molecular_function	cellular_component
YPL189C-A	COA2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00785166336202716	0.649330679311297	1796	Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrial matrix
YER114C	BOI2	hom	FT	SIGNALING|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.00782652768638527	0.650378409046767	1797	Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication	cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction	phospholipid binding	site of polarized growth|cellular bud|cellular bud neck
YGL152C_d	YGL152C	hom			0.00782545338643557	0.650423204478616	1798	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W	Unknown	Unknown	Unknown
YGL004C	RPN14	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS	0.00782282526984013	0.65087346815514	1799	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p	proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|cytoplasm
YDL061C	RPS29B	hom	FT	TRANSLATION|RIBOSOME	0.00782092995284836	0.650611833396278	1800	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YNL243W	SLA2	hom	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON	0.007819498215352	0.650671542061212	1801	Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo	bipolar cellular bud site selection|fungal-type cell wall organization|actin filament organization|endocytosis|exocytosis	protein binding, bridging	incipient cellular bud site|mating projection tip|actin cortical patch
YMR116C	ASC1	hom	FT	SIGNALING|TRANSLATION|RIBOSOME	0.00781379427883917	0.650909439219141	1802	G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation	negative regulation of translation|glucose mediated signaling pathway|G-protein coupled receptor signaling pathway|invasive growth in response to glucose limitation	G-protein alpha-subunit binding|GDP-dissociation inhibitor activity|signal transducer activity	cytosolic small ribosomal subunit|cytoplasm
YNL102W	POL1	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.00781082454447151	0.651033313605323	1803	Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis	RNA-dependent DNA replication|lagging strand elongation|DNA synthesis involved in DNA repair|DNA replication|DNA replication initiation|premeiotic DNA replication	DNA-directed DNA polymerase activity	mitochondrion|alpha DNA polymerase:primase complex|replication fork
YMR118C_p	SHH3	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.00780905525769249	0.651107119166828	1804	Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase	biological_process	molecular_function	integral to membrane
YLR418C	CDC73	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|CHROMOSOME|RNA POL II, HOLOENZYME	0.00779616973074012	0.651644740268065	1805	Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress	transcription elongation from RNA polymerase I promoter|negative regulation of DNA recombination|mRNA 3'-end processing|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair|transcription elongation from RNA polymerase II promoter	chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YIL100W_d	YIL100W	hom			0.00779581906422836	0.651659373611635	1806	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A	Unknown	Unknown	Unknown
YCR073C	SSK22	hom	FT	SIGNALING|PROTEIN PHOSPHORYLATION	0.00778924931095097	0.651933554764387	1807	MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p	MAPK cascade involved in osmosensory signaling pathway|protein phosphorylation	protein kinase activity|MAP kinase kinase kinase activity	cellular_component
YDR251W	PAM1	hom	FT	OXIDATION-REDUCTION PROCESS|SITE OF POLARIZED GROWTH	0.0077823738133628	0.652220546179026	1808	Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype	pseudohyphal growth	molecular_function	cellular bud|cellular bud neck
YJL139C	YUR1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00775649453040073	0.653301239384868	1809	Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication	cell wall mannoprotein biosynthetic process|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YLR295C	ATP14	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.00774545962514077	0.65376226742351	1810	Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress	cristae formation|mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YDL166C	FAP7	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.00774056514968348	0.653966796340613	1811	Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D	cellular response to oxidative stress|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit export from nucleus	nucleoside-triphosphatase activity	nucleus|preribosome|cytoplasm
YKR032W_d	YKR032W	hom			0.00773813688696208	0.654406006994412	1812	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL127C	HHO1	hom	FT	CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.00773643753566171	0.654139300066456	1813	Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination	negative regulation of DNA recombination|negative regulation of chromatin silencing|regulation of transcription, DNA-dependent	DNA binding	nucleus|nuclear nucleosome
YNL222W	SSU72	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00772614789857641	0.654569411144575	1814	Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo	transcription initiation from RNA polymerase II promoter|mRNA 3'-end processing|mRNA cleavage|termination of RNA polymerase II transcription|termination of RNA polymerase II transcription, poly(A)-coupled|transcription antitermination|transcriptional start site selection at RNA polymerase II promoter|dephosphorylation of RNA polymerase II C-terminal domain|termination of RNA polymerase II transcription, exosome-dependent|snoRNA transcription|transcription elongation from RNA polymerase II promoter	protein tyrosine phosphatase activity|phosphoprotein phosphatase activity|CTD phosphatase activity	mRNA cleavage and polyadenylation specificity factor complex|nucleus
YCR020C-A	MAK31	hom			0.00770525999502185	0.655442886571549	1815	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex
YNL314W	DAL82	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.00769914309837607	0.655698767865171	1816	Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain	allantoin catabolic process|nitrogen catabolite activation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YPL143W	RPL33A	het	FT	TRANSLATION|RIBOSOME	0.00768969075433105	0.656574436156477	1817	Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YEL051W	VMA8	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.00768775025227384	0.65617545972487	1818	Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YER063W	THO1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION|NUCLEUS	0.00768506419168487	0.656527735059308	1819	Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation	poly(A)+ mRNA export from nucleus|transcription, DNA-dependent|ribonucleoprotein complex assembly	chromatin binding|double-stranded DNA binding|RNA binding	nucleus
YPL074W	YTA6	hom			0.00763314887606442	0.658461994150215	1820	Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress	biological_process	ATPase activity	cell cortex
YOL003C	PFA4	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00762316190501082	0.658880563559195	1821	Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases	protein palmitoylation	palmitoyltransferase activity	integral to membrane|endoplasmic reticulum
YNL069C	RPL16B	hom	FT	TRANSLATION|RIBOSOME	0.0076117654609552	0.659358336673842	1822	Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YGR198W	YPP1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|PLASMA MEMBRANE|CYTOSKELETON	0.00760402687277315	0.660063471116569	1823	Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene	receptor-mediated endocytosis|response to pheromone|protein targeting to vacuole	molecular_function	endosome|cytosol|ribosome|plasma membrane|actin cortical patch|cytoplasm
YPL052W	OAZ1	hom	FT	TRANSLATION|PROTEOLYSIS	0.00760357898475387	0.659939443184698	1824	Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p	Unknown|regulation of proteasomal protein catabolic process	ornithine decarboxylase inhibitor activity	cytoplasm
YER113C	TMN3	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00760106459282824	0.659807075653193	1825	Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation	cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|invasive growth in response to glucose limitation	molecular_function	COPI-coated vesicle|integral to membrane|Golgi apparatus
YGR091W	PRP31	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS|MITOCHONDRION	0.00756759303822602	0.661211488649465	1826	Splicing factor, component of the U4/U6-U5 snRNP complex	mRNA splicing, via spliceosome|spliceosomal snRNP assembly	molecular_function	mitochondrion|U4/U6 x U5 tri-snRNP complex
YKL120W	OAC1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.00756292768830905	0.661454675695159	1827	Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family	sulfate transport|oxaloacetate transport|isopropylmalate transport	secondary active sulfate transmembrane transporter activity|oxaloacetate secondary active transmembrane transporter activity|isopropylmalate transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YKL046C	DCW1	hom	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|PLASMA MEMBRANE	0.00755434013190621	0.661767889375955	1828	Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p	fungal-type cell wall biogenesis|budding cell bud growth	mannosidase activity	anchored to plasma membrane
YIL067C_p	YIL067C	hom			0.00755063715836386	0.661923385814406	1829	Uncharacterized protein of unknown function	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YGR194C	XKS1	hom	FT	CARBOHYDRATE METABOLISM	0.00754429030219696	0.6621899389059	1830	Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains	xylulose catabolic process	xylulokinase activity	cytoplasm
YIL163C_p	YIL163C	hom			0.00753605795307633	0.662535742023704	1831	Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YJR130C	STR2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.00751783018828261	0.663631628856098	1832	Cystathionine gamma-synthase, converts cysteine into cystathionine	sulfur compound metabolic process|transsulfuration	cystathionine gamma-synthase activity	nucleus|cytoplasm
YOR296W_p	YOR296W	hom			0.00751478053632417	0.663618281501175	1833	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene	biological_process	molecular_function	cytoplasm
YJR100C	AIM25	hom	FT	MITOCHONDRION	0.00750675856336191	0.663955334586544	1834	Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YGR159C	NSR1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION	0.00749874564305958	0.664103961334156	1835	Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis	ribosomal small subunit assembly|rRNA processing	single-stranded DNA binding|RNA binding	mitochondrion|nucleolus|nucleus
YBR050C	REG2	hom	FT	TRANSCRIPTION FROM RNA POL II	0.00749164355302151	0.664402625816757	1836	Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease	negative regulation of transcription from RNA polymerase II promoter	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex
YGR160W_d	YGR160W	hom			0.00740987179890599	0.667845204220645	1837	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR074W	SMD1	het	FT	RNA PROCESSING|NUCLEUS	0.00740798090293846	0.667924893695608	1838	Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1; protein abundance increases in response to DNA replication stress	mRNA splicing, via spliceosome	mRNA binding	commitment complex|U1 snRNP|U4/U6 x U5 tri-snRNP complex|U2-type prespliceosome|U5 snRNP
YLL038C	ENT4	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.00740485847511578	0.668056492750503	1839	Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome	endocytosis|actin filament organization|establishment of protein localization to plasma membrane|actin cortical patch assembly	clathrin binding	actin cortical patch
YPL186C	UIP4	hom	FT	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.00739849317762997	0.668324798636752	1840	Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope	biological_process	molecular_function	mitochondrial outer membrane|nuclear envelope|endoplasmic reticulum
YDR037W	KRS1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.00739570598345627	0.668442295972434	1841	Lysyl-tRNA synthetase	lysyl-tRNA aminoacylation	lysine-tRNA ligase activity	cytoplasm
YGL134W	PCL10	hom	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.00735504047883544	0.670157518626293	1842	Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate	negative regulation of glycogen biosynthetic process|regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YDL047W	SIT4	hom	FT	CELL CYCLE|RNA PROCESSING|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.00735101574338673	0.670327370883036	1843	Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization	intracellular protein kinase cascade|replicative cell aging|G1/S transition of mitotic cell cycle|actin cytoskeleton organization|DNA repair|cellular response to oxidative stress|fungal-type cell wall organization|TOR signaling cascade|dephosphorylation|tRNA wobble uridine modification	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YGR069W_d	YGR069W	hom			0.00732020028993348	0.67181285597574	1844	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR204C-A_p	YGR204C-A	hom			0.00731566337444187	0.67182003784966	1845	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YNL055C	POR1	hom	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.00731388412376055	0.671895196602253	1846	Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication	DNA transport|mitochondrion organization|apoptotic process|ion transport|cell redox homeostasis	voltage-gated anion channel activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YNR054C	ESF2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00731098115807863	0.672017830138267	1847	Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|small-subunit processome assembly|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATPase activator activity|RNA binding	nucleolus|90S preribosome|cytoplasm
YCR060W	TAH1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEUS	0.00730458777955422	0.672287944224349	1848	Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II	protein folding|box C/D snoRNP assembly	chaperone binding	R2TP complex|nucleus|cytoplasm
YIL160C	POT1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0072969190061221	0.67261199829997	1849	3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids	fatty acid beta-oxidation	mRNA binding|acetyl-CoA C-acyltransferase activity	peroxisomal matrix|peroxisome
YOL030W	GAS5	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.00728448203053763	0.673137668227917	1850	1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall	(1->3)-beta-D-glucan metabolic process	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane
YKR100C	SKG1	hom	FT	CELL WALL ORG/BIOGENESIS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.00725330566114927	0.674501845750146	1851	Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell	fungal-type cell wall organization	molecular_function	incipient cellular bud site|cellular bud|cellular bud tip
YGL218W_d	YGL218W	hom			0.00723535442244013	0.675444072212036	1852	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YDR262W_p	YDR262W	hom			0.00723259392784947	0.675332527282054	1853	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment	biological_process	molecular_function	fungal-type vacuole
YDR206W	EBS1	hom	FT	TRANSLATION|NUCLEUS|CHROMOSOME	0.00722389236556257	0.675746473989439	1854	Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors	negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YLR455W	YLR455W	hom	FT	NUCLEUS	0.00722176063077708	0.675791123328342	1855	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YCR034W	FEN1	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00721525951882508	0.676066386709361	1856	Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication	fatty acid elongation|vesicle-mediated transport|sphingolipid biosynthetic process	fatty acid elongase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YDR043C	NRG1	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.00719416938007675	0.676959661443906	1857	Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter by glucose|cellular hyperosmotic salinity response|biofilm formation|negative regulation of transcription from RNA polymerase II promoter|pseudohyphal growth|Unknown	RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nucleus
YLR342W	FKS1	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON	0.00719261428769638	0.677025545525605	1858	Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling	(1->3)-beta-D-glucan biosynthetic process|positive regulation of endocytosis|regulation of cell size	1,3-beta-D-glucan synthase activity	mitochondrion|1,3-beta-D-glucan synthase complex|integral to membrane|plasma membrane|cellular bud neck|cellular bud tip|actin cortical patch
YCL045C	EMC1	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00717120833832387	0.677932695111978	1859	Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YNL322C	KRE1	hom	FT	CELL WALL ORG/BIOGENESIS|PLASMA MEMBRANE	0.00717105324089865	0.677939269595735	1860	Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall|integral to membrane
YPR151C	SUE1	hom	FT	PROTEOLYSIS|MITOCHONDRION	0.00716872955612383	0.678037772087977	1861	Mitochondrial protein required for degradation of unstable forms of cytochrome c	protein catabolic process	molecular_function	mitochondrial envelope
YPL088W_p	YPL088W	hom	FT	OXIDATION-REDUCTION PROCESS	0.00716739431039049	0.678094376502053	1862	Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YLR268W	SEC22	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.00714241375689006	0.679153699275715	1863	R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion with endoplasmic reticulum|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle membrane
YKR057W	RPS21A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.00713946783971108	0.679414168180794	1864	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YKL095W	YJU2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.00713397835499286	0.679511553288299	1865	Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing	generation of catalytic spliceosome for first transesterification step	first spliceosomal transesterification activity	nucleus|U2-type catalytic step 1 spliceosome
YKL191W	DPH2	hom			0.00712817837973459	0.679757646812249	1866	Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	molecular_function	cytoplasm
YOL121C	RPS19A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME	0.0071178160817529	0.680197405031418	1867	Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit biogenesis|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR154C_d	YDR154C	hom			0.00710686896901436	0.680707088441238	1868	Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein	Unknown	Unknown	Unknown
YDR231C	COX20	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.00709575880613906	0.681133840039588	1869	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase	mitochondrial respiratory chain complex IV assembly|protein processing|aerobic respiration	unfolded protein binding	mitochondrion|mitochondrial inner membrane
YGR136W	LSB1	hom	FT	NUCLEUS	0.00708593301446945	0.681685807888988	1870	Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YDL016C_d	YDL016C	het			0.00705349439538047	0.682929534801453	1871	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication	Unknown	Unknown	Unknown
YLR262C	YPT6	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|GOLGI APPARATUS|PLASMA MEMBRANE	0.00704451751889699	0.683802854366339	1872	Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6	intracellular protein transport|retrograde transport, endosome to Golgi	GTPase activity	Golgi apparatus
YAL029C	MYO4	hom	FT	RNA LOCALIZATION|MITOCHONDRION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.00704157991246776	0.68343607212457	1873	Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication	mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization	microfilament motor activity|actin filament binding	mitochondrion|filamentous actin|myosin V complex|cellular bud|cellular bud tip
YNL190W_p	YNL190W	hom			0.00701720562489119	0.684472774471606	1874	Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site	cellular response to water deprivation	molecular_function	fungal-type cell wall
YJR069C	HAM1	hom	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.00701534586908331	0.684551899196556	1875	Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine; protein abundance increases in response to DNA replication stress	purine deoxyribonucleoside triphosphate catabolic process|pyrimidine deoxyribonucleoside triphosphate catabolic process	dITP diphosphatase activity|ITP diphosphatase activity|XTP diphosphatase activity|dCTP diphosphatase activity|UTP diphosphatase activity|dTTP diphosphatase activity|dATP pyrophosphohydrolase activity|dGTP diphosphatase activity|dUTP diphosphatase activity|GTP diphosphatase activity	nucleus|cytoplasm
YOR083W	WHI5	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS	0.00699829795027754	0.685277377025105	1876	Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1	negative regulation of transcription involved in G1/S phase of mitotic cell cycle|regulation of cell size	RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	SBF transcription complex|nucleus|cytoplasm
YLR329W	REC102	hom	FT	CELL CYCLE|NUCLEUS|CHROMOSOME	0.00699737274965712	0.685627790999074	1877	Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome|nucleus
YKL086W	SRX1	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0069972112773993	0.685323630466567	1878	Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress	sulfiredoxin activity	nucleus|cytoplasm
YHL042W_p	YHL042W	hom			0.00698861614938225	0.685689517374027	1879	Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	cellular_component
YDR083W	RRP8	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|CHROMOSOME	0.00698109968153678	0.686009547077597	1880	Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1	rRNA processing	methyltransferase activity	nucleolus
YMR027W_p	YMR027W	hom	FT	NUCLEUS	0.0069722751095986	0.686385343955202	1881	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YKR041W	YKR041W	hom	FT	NUCLEUS|CYTOSKELETON	0.00697058957457874	0.686501399740166	1882	Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking	biological_process	molecular_function	nucleus|mitotic spindle|cytoplasm
YDR513W	GRX2	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.00696900669323038	0.686524550061589	1883	Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication	cellular response to oxidative stress	disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity	cytosol|mitochondrion
YEL045C_d	YEL045C	hom			0.00696589194168132	0.686657221274944	1884	Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress	Unknown	Unknown	Unknown
YOR229W	WTM2	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS	0.00694149828418558	0.687696589795288	1885	Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats	negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter during meiosis|cellular protein complex localization|negative regulation of chromatin silencing at telomere|response to DNA damage stimulus|positive regulation of transcription from RNA polymerase II promoter	protein binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription corepressor activity	nucleus
YJL182C_d	YJL182C	hom			0.00693926697916845	0.687791691050135	1886	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W	Unknown	Unknown	Unknown
YJL026W	RNR2	het	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|NUCLEUS	0.00692470558577109	0.688456462216438	1887	Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits	deoxyribonucleotide biosynthetic process	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ribonucleoside-diphosphate reductase complex|nucleus|cytoplasm
YPL038W	MET31	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.00691429769890744	0.688856252120352	1888	Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication	regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YJL209W	CBP1	hom	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0068877439184017	0.690164394191753	1889	Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress	mitochondrial mRNA catabolic process|aerobic respiration	mRNA binding	mitochondrion|extrinsic to mitochondrial inner membrane
YDR250C_d	YDR250C	hom			0.00688273991827931	0.690202594211121	1890	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL088W_d	YGL088W	hom			0.00685680020903685	0.691309988332166	1891	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing	Unknown	Unknown	Unknown
YFL013C	IES1	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.00684786126309311	0.692040864714072	1892	Subunit of the INO80 chromatin remodeling complex	nucleosome mobilization	molecular_function	nucleus|Ino80 complex
YBR200W-A_p	YBR200W-A	hom			0.006846515763973	0.691749225320056	1893	Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YER016W	BIM1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.00684326017066699	0.691888289631552	1894	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally	nuclear migration along microtubule|microtubule nucleation|microtubule depolymerization|negative regulation of microtubule depolymerization|positive regulation of microtubule polymerization|mitotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint	microtubule plus-end binding|protein homodimerization activity|structural constituent of cytoskeleton	spindle midzone|microtubule plus end|cytoplasmic microtubule|spindle pole body|kinetochore|spindle pole|spindle
YGL081W_p	YGL081W	hom			0.00683982443298837	0.692035060164753	1895	Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis	biological_process	molecular_function	cellular_component
YPL224C	MMT2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.0068365868848396	0.692173374863582	1896	Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p	cellular iron ion homeostasis	molecular_function	mitochondrion|integral to membrane
YDR133C_d	YDR133C	hom			0.00683295294090815	0.692764298123399	1897	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C	Unknown	Unknown	Unknown
YDR505C	PSP1	hom	FT	MITOCHONDRION	0.00683041500936085	0.692785438262244	1898	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|cytoplasm
YLR422W_p	YLR422W	hom			0.00681876292062274	0.692935034849902	1899	Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein	biological_process	molecular_function	cytoplasm
YMR095C	SNO1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0068078285479038	0.693402440006586	1900	Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase	pyridoxine metabolic process|thiamine biosynthetic process|anti-apoptosis	molecular_function	cytoplasm
YLR327C	TMA10	hom	FT	NUCLEUS|MITOCHONDRION	0.00679821590705405	0.694768770915339	1901	Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YOR317W	FAA1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.00678531613333194	0.694365131997595	1902	Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms ER foci upon DNA replication stress; FAA1 has a paralog, FAA4, that arose from the whole genome duplication	long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process	long-chain fatty acid-CoA ligase activity	mitochondrial outer membrane|mitochondrion|lipid particle|plasma membrane
YNL194C	YNL194C	hom	FT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.00678355208901067	0.694440588174101	1903	Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate	ascospore formation	molecular_function	cell cortex|integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YBL055C	YBL055C	hom	FT	RESPONSE TO OXIDATIVE STRESS	0.00677671928406945	0.694732886794089	1904	3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases	cellular response to oxidative stress|apoptotic DNA fragmentation	3'-5'-exodeoxyribonuclease activity|endonuclease activity	cytoplasm
YMR290C	HAS1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|ENDOMEMBRANE SYSTEM|NUCLEUS	0.0067698567456241	0.69502650304531	1905	ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles	rRNA processing	RNA binding|RNA-dependent ATPase activity|ATP-dependent RNA helicase activity	nuclear envelope|nucleolus|preribosome, large subunit precursor|90S preribosome
YFR044C	DUG1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS|MITOCHONDRION	0.00676472563164976	0.695246069539852	1906	Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	metallodipeptidase activity|omega peptidase activity	mitochondrion|ribosome|cytoplasm
YCR083W	TRX3	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.00675841046406789	0.695516338173537	1907	Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p	cellular response to oxidative stress	disulfide oxidoreductase activity	mitochondrion
YOR276W	CAF20	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	0.00675644467678015	0.695600475369741	1908	Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E	negative regulation of translation|positive regulation of cytoplasmic mRNA processing body assembly	translation regulator activity	mRNA cap binding complex
YNL001W	DOM34	hom	FT	CELL CYCLE|TRANSLATION|CELL DIVISION	0.00674282351119222	0.696312735646523	1909	Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication	nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|nonfunctional rRNA decay	ribosome binding|endoribonuclease activity	cytoplasm
YGR067C_p	YGR067C	hom	FT	NUCLEUS	0.00671967848149143	0.697475387477151	1910	Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p	biological_process	sequence-specific DNA binding	cellular_component
YBL008W	HIR1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.00671161912288556	0.697734518082415	1911	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores	DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter	nucleosome binding|transcription corepressor activity|DNA binding	chromosome, centromeric region|HIR complex|nucleus
YOR183W_p	FYV12	hom			0.00670934613963341	0.697617446664124	1912	Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	cellular_component
YML010W	SPT5	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.00670767316403892	0.697689130396876	1913	Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair	7-methylguanosine mRNA capping|intracellular mRNA localization|mRNA splicing, via spliceosome|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair	core RNA polymerase I binding transcription factor activity|core RNA polymerase II binding transcription factor activity|rRNA binding|RNA polymerase II core binding|RNA polymerase I transcription factor binding|RNA polymerase I core binding	DSIF complex|mitochondrion|rDNA heterochromatin|nucleus
YDL156W	CMR1	hom	FT	NUCLEUS|CHROMOSOME	0.00668852022513457	0.698509988385571	1914	DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS	biological_process	DNA binding	nuclear chromatin|nucleus|cytoplasm
YHR069C	RRP4	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION|NUCLEUS	0.0066768764922363	0.699137276401766	1915	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)	nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|polyadenylation-dependent snoRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YFR010W	UBP6	hom	FT	PROTEOLYSIS	0.00666913440743135	0.699341186136811	1916	Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance	protein deubiquitination	ubiquitin-specific protease activity	proteasome complex|proteasome regulatory particle
YLR035C	MLH2	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.00666554262286723	0.699495229199622	1917	Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p	mismatch repair|reciprocal meiotic recombination	molecular_function	nucleus
YOR073W	SGO1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.00665469831609816	0.699960390609483	1918	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability	positive regulation of maintenance of meiotic sister chromatid cohesion|meiotic sister chromatid segregation|meiotic sister chromatid separation|sister chromatid biorientation|maintenance of meiotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint|mitotic sister chromatid segregation	molecular_function	condensed nuclear chromosome kinetochore|nucleus|spindle pole body|condensed nuclear chromosome, centromeric region
YIL145C	PAN6	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.00665372583533085	0.70017240431909	1919	Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC	pantothenate biosynthetic process	pantoate-beta-alanine ligase activity	nucleus|cytoplasm
YER020W	GPA2	hom	FT	SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE	0.00665060489423495	0.700136005270844	1920	Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	adenylate cyclase-activating G-protein coupled receptor signaling pathway|ascospore formation|replicative cell aging|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|regulation of cell size	GTPase activity	mitochondrion|plasma membrane
YNL062C	GCD10	het	FT	RNA PROCESSING|TRANSLATION|NUCLEUS	0.00665000019574602	0.700459898356192	1921	Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression	tRNA methylation	tRNA (adenine-N1-)-methyltransferase activity	tRNA (m1A) methyltransferase complex|nucleus
YIR030C	DCG1	hom			0.00664853755756486	0.700224703571889	1922	Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain	nitrogen compound metabolic process	molecular_function	cellular_component
YNL073W	MSK1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION|MITOCHONDRION	0.0066472556190389	0.700279706714319	1923	Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)	tRNA import into mitochondrion|lysyl-tRNA aminoacylation|mitochondrial lysyl-tRNA aminoacylation|mitochondrial translation	lysine-tRNA ligase activity	mitochondrion
YGR146C	ECL1	hom			0.0066394876875327	0.700613032925022	1924	Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	cellular_component
YDR471W	RPL27B	hom	FT	TRANSLATION|RIBOSOME	0.00662586537381843	0.701197713013456	1925	Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YHR029C	YHI9	hom	FT	SIGNALING	0.00662213605378978	0.701654693672225	1926	Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production	endoplasmic reticulum unfolded protein response	molecular_function	cellular_component
YLR338W_d	OPI9	hom	FF		0.00659328396320093	0.702596849063578	1927	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C	Unknown	Unknown	Unknown
YOL047C_p	YOL047C	hom			0.00659032440572471	0.702723990660067	1928	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	integral to membrane|cytoplasm
YPL078C	ATP4	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION	0.00656639234492266	0.703752409089858	1929	Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated	protein complex oligomerization|ATP synthesis coupled proton transport	proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase, stator stalk|integral to membrane
YKL194C	MST1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00656343145372947	0.703879683436007	1930	Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro	mitochondrial threonyl-tRNA aminoacylation	threonine-tRNA ligase activity	mitochondrion
YLL020C_d	YLL020C	hom			0.00656019786638393	0.704018689138598	1931	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1	Unknown	Unknown	Unknown
YNL237W	YTP1	hom	FF|FT	MITOCHONDRION	0.00654148911732553	0.70482313620189	1932	Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins	biological_process	molecular_function	integral to membrane|membrane
YNL149C	PGA2	het	FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.00653386634783241	0.705318668040147	1933	Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect	protein transport	molecular_function	nuclear envelope|endoplasmic reticulum
YBL010C_p	YBL010C	hom	FT	NUCLEUS	0.00652175990378313	0.705671819218789	1934	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles	biological_process	molecular_function	clathrin-coated vesicle
YGR117C_p	YGR117C	hom			0.00651746718097187	0.705856525944237	1935	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YHR156C	LIN1	hom	FT	NUCLEUS|CHROMOSOME	0.00651630027619832	0.705906738367888	1936	Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication	biological_process	protein binding	chromatin|nucleus|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YLL051C	FRE6	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.00651065101217452	0.706191625835554	1937	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels	intracellular sequestering of iron ion|copper ion import	ferric-chelate reductase activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YLL044W_d	YLL044W	hom			0.00649994161481713	0.706610793383769	1938	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant	Unknown	Unknown	Unknown
YNL195C_p	YNL195C	hom	FT	MITOCHONDRION	0.00649788613366149	0.706699276318659	1939	Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YER076C_p	YER076C	hom	FT	MITOCHONDRION	0.00646973435706292	0.707911532811539	1940	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization	biological_process	molecular_function	mitochondrion
YLR314C	CDC3	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.00646690059192916	0.708199793665056	1941	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells	septin ring disassembly|maintenance of cell polarity|cell cycle cytokinesis|septin ring assembly	structural molecule activity|GTP binding|1-phosphatidylinositol binding	mating projection base|septin filament array|cellular bud neck septin ring|septin complex|prospore membrane|ascospore wall
YMR326C_d	YMR326C	hom			0.00646444389345594	0.708139430601475	1942	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13	Unknown	Unknown	Unknown
YKL213C	DOA1	hom	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS	0.0064557646120399	0.70905310828769	1943	WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress	double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process	ubiquitin binding	nucleus|cytoplasm
YKL053C-A	MDM35	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|NUCLEUS|MITOCHONDRION	0.00644742564235059	0.708872704493908	1944	Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	mitochondrion organization|mitochondrial respiratory chain complex assembly	molecular_function	nucleus|cytoplasm|mitochondrial intermembrane space
YDR365C	ESF1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00643213805033553	0.709779817732197	1945	Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels	rRNA processing	RNA binding	nucleolus|nucleus
YGL033W	HOP2	hom	FF|FT	CELL CYCLE|NUCLEUS|CHROMOSOME	0.00642136032194962	0.709996316751937	1946	Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair	synapsis|reciprocal meiotic recombination	protein binding|double-stranded DNA binding	condensed nuclear chromosome
YPL191C_p	YPL191C	hom			0.00642125797015604	0.710000730132004	1947	Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YKR075C_p	YKR075C	hom	FT	NUCLEUS	0.00641754822731995	0.710160699743964	1948	Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YDR238C	SEC26	het	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00641313631486877	0.710350964570871	1949	Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)	ER to Golgi vesicle-mediated transport	molecular_function	coated vesicle|COPI vesicle coat
YDR176W	NGG1	hom	FF|FT	CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.00641005572477253	0.710483826488982	1950	Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex	histone acetylation|chromatin modification	histone acetyltransferase activity|transcription cofactor activity	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YBL053W_d	YBL053W	hom			0.00640486817543486	0.7107075787424	1951	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL217W	JEN1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION|PLASMA MEMBRANE	0.0063998340010213	0.711089447538422	1952	Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose	plasma membrane lactate transport|plasma membrane selenite transport|plasma membrane pyruvate transport	selenite:hydrogen symporter activity|secondary active monocarboxylate transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YIR033W	MGA2	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.00639354110516622	0.711196230811661	1953	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	molecular_function	integral to endoplasmic reticulum membrane|nucleus
YBR023C	CHS3	hom	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH	0.00639318694916896	0.711211511085641	1954	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan	ascospore wall assembly|fungal-type cell wall chitin biosynthetic process|cytokinesis	chitin synthase activity	incipient cellular bud site|integral to membrane|chitosome|prospore membrane|cellular bud neck|mating projection tip|cytoplasm
YER122C	GLO3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00639006523645898	0.711387316614551	1955	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p	retrograde vesicle-mediated transport, Golgi to ER|COPI coating of Golgi vesicle|ER to Golgi vesicle-mediated transport	ARF GTPase activator activity	COPI-coated vesicle|endoplasmic reticulum-Golgi intermediate compartment|COPI vesicle coat
YOR092W	ECM3	hom	FT	CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00638007144134783	0.712682331567108	1956	Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication	fungal-type cell wall organization	ATPase activity	integral to membrane|endoplasmic reticulum
YMR164C	MSS11	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|NUCLEUS	0.00637808335344654	0.711863272693505	1957	Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals	biofilm formation|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YPL141C	FRK1	hom	FT	PROTEIN PHOSPHORYLATION	0.00637387210553237	0.712168125097178	1958	Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication	protein phosphorylation	protein kinase activity	cytoplasm
YDL090C	RAM1	hom	FF|FT	PROTEIN PRENYLATION	0.00634820974317162	0.714012948831682	1959	Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit	protein farnesylation	protein farnesyltransferase activity	protein farnesyltransferase complex
YBL103C	RTG3	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|SIGNALING|NUCLEUS	0.00634498934113632	0.713292105482539	1960	Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways	mitochondrion degradation|cellular response to oleic acid|mitochondria-nucleus signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription factor import into nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus|cytoplasm
YPL248C	GAL4	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0063173573441964	0.714485886861731	1961	DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p	galactose metabolic process|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YNL155W	YNL155W	hom	FT	NUCLEUS	0.00631429711675019	0.714658830940866	1962	Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YGR187C	HGH1	hom			0.00630328011896958	0.715134961065537	1963	Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	cytoplasm
YBR281C	DUG2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS|NUCLEUS	0.00629824040442065	0.715312202488741	1964	Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	peptidase activity|gamma-glutamyltransferase activity|omega peptidase activity	nucleus|cytoplasm
YDR002W	YRB1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|PROTEOLYSIS|RNA LOCALIZATION|NUCLEUS	0.00629686398738498	0.715818611635048	1965	Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1	RNA export from nucleus|protein import into nucleus|G1/S transition of mitotic cell cycle|ubiquitin-dependent protein catabolic process	Ran GTPase binding	nucleus|cytoplasm
YER038C	KRE29	het	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.00627589054054251	0.716278681775454	1966	Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance	DNA repair	molecular_function	Smc5-Smc6 complex|nucleus|cytoplasm
YMR199W	CLN1	hom	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.00627053575273161	0.716550753183493	1967	G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)	regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase regulator activity	nucleus|cytoplasm
YOL015W	IRC10	hom			0.00626699938778251	0.716825034848178	1968	Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YGL258W	VEL1	hom			0.00626348484012776	0.716815340026665	1969	Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C	biological_process	molecular_function	cytosol
YPR168W	NUT2	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.00625512651803354	0.717176991561499	1970	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	molecular_function	core mediator complex
YJL077C	ICS3	hom			0.00622206391149265	0.718648353345007	1971	Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2	biological_process	molecular_function	cellular_component
YLR219W	MSC3	hom	FT	CELL CYCLE|PLASMA MEMBRANE	0.00621377041393048	0.718967336864837	1972	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress	reciprocal meiotic recombination	molecular_function	cellular_component
YHL035C	VMR1	hom	FT	NUCLEOTIDE METABOLISM|MITOCHONDRION	0.00620575789657048	0.71931438510581	1973	Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions	transport|response to drug|response to metal ion|drug transport	ATPase activity, coupled to transmembrane movement of substances	fungal-type vacuole membrane|mitochondrion|integral to membrane|ribosome
YOR302W	YOR302W	hom	FT	TRANSLATION	0.00619160125195673	0.719927696883124	1974	CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA	regulation of translation	translation regulator activity	cytosol
YDR221W	GTB1	hom	FT	CARBOHYDRATE METABOLISM|ENDOPLASMIC RETICULUM	0.00617300169072847	0.720853477544472	1975	Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress	polysaccharide biosynthetic process|protein N-linked glycosylation	alpha-glucosidase activity	glucosidase II complex|endoplasmic reticulum|endoplasmic reticulum lumen
YLR264C-A_p	YLR264C-A	hom			0.00616530849554735	0.721067262346567	1976	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOL071W	EMI5	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.00613667883697155	0.722308816817228	1977	Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)	protein-FAD linkage|cellular respiration|mitochondrial electron transport, succinate to ubiquinone|ascospore formation|tricarboxylic acid cycle|positive regulation of transcription from RNA polymerase II promoter	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial matrix
YMR322C_p	SNO4	hom	FT	PROTEOLYSIS	0.00612849313117063	0.722663932922654	1978	Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation	biological_process	cysteine-type peptidase activity	cellular_component
YOR176W	HEM15	het	FT	COFACTOR METABOLISM|MITOCHONDRION	0.00612701758248326	0.722767590338667	1979	Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway	heme biosynthetic process	ferrochelatase activity	mitochondrion|mitochondrial inner membrane
YNL011C_p	YNL011C	hom			0.00612634216906673	0.722757256874822	1980	Putative protein of unknown function; YNL011C is not an essential gene	biological_process	molecular_function	cellular_component
YJR021C	REC107	hom	FT	CELL CYCLE|NUCLEUS|CHROMOSOME	0.00612125908533405	0.722977813385173	1981	Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation	reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YJL073W	JEM1	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.00611919677177383	0.723106898223522	1982	DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2	karyogamy involved in conjugation with cellular fusion|ER-associated protein catabolic process|protein folding in endoplasmic reticulum	unfolded protein binding|chaperone binding	endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YDL190C	UFD2	hom	FT	PROTEOLYSIS|NUCLEUS	0.00611553233121414	0.723345065864963	1983	Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3	ER-associated protein catabolic process|protein ubiquitination|ubiquitin-dependent protein catabolic process|response to stress	ubiquitin-ubiquitin ligase activity	nucleus|cytoplasm
YLL010C	PSR1	hom	FT	PLASMA MEMBRANE	0.00611222700072342	0.72336977496099	1984	Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p	response to stress	phosphoprotein phosphatase activity	plasma membrane
YER085C_p	YER085C	hom			0.006084525307935	0.724611783175743	1985	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR039C	MSC7	hom	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|ENDOPLASMIC RETICULUM	0.00608217423638422	0.724910887796403	1986	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids	reciprocal meiotic recombination	molecular_function	integral to membrane|endoplasmic reticulum
YMR135C	GID8	hom	FT	KETONE METABOLISM|CELL CYCLE|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS	0.00607911195980595	0.724807474298588	1987	Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|traversing start control point of mitotic cell cycle	molecular_function	nucleus|GID complex|cytoplasm
YIL057C	RGI2	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.00607536211745175	0.724970336075474	1988	Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose	energy reserve metabolic process	molecular_function	cytoplasm
YLR231C	BNA5	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.00606289857025708	0.725511737617281	1989	Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p	de novo NAD biosynthetic process from tryptophan	kynureninase activity	nucleus|cytoplasm
YIL086C_d	YIL086C	hom			0.00606059725283093	0.72561171909412	1990	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER152C	YER152C	hom	FT	NUCLEUS	0.00605242635897247	0.72596674396198	1991	Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene	biological_process	2-aminoadipate transaminase activity	nucleus|cytoplasm
YNL339C	YRF1-6	hom	FT	NUCLEUS	0.00604815012712672	0.726191760383721	1992	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p	telomere maintenance via recombination	DNA helicase activity	nucleus
YML017W	PSP2	hom			0.00603868658812895	0.726563868881274	1993	Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing	biological_process	molecular_function	cytoplasm
YMR306W	FKS3	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE	0.00603208829895841	0.726850686933743	1994	Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	ascospore wall assembly	1,3-beta-D-glucan synthase activity	mitochondrion|integral to membrane
YDL068W_d	YDL068W	hom			0.00602871417883168	0.726997369828682	1995	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR200W	ROT1	het	FT	CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|CYTOSKELETON ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00602642664554364	0.727096821297438	1996	Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation	budding cell apical bud growth|cell cycle cytokinesis|establishment or maintenance of actin cytoskeleton polarity|protein O-linked mannosylation|endoplasmic reticulum unfolded protein response|protein folding|fungal-type cell wall biogenesis|'de novo' protein folding|protein N-linked glycosylation	unfolded protein binding	endoplasmic reticulum|endoplasmic reticulum membrane
YBR123C	TFC1	het	FT	NUCLEUS	0.00602355429000399	0.727221704667103	1997	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63	transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter	RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending	transcription factor TFIIIC complex
YML117W	NAB6	hom			0.00602279635401561	0.727528123116658	1998	Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP	biological_process	molecular_function	cytoplasm
YJR083C	ACF4	hom			0.00600912299189428	0.727849253654073	1999	Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate	biological_process	molecular_function	cellular_component
YPR148C	YPR148C	hom			0.00600822812985404	0.727888172988715	2000	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	ribosome|cytoplasm
YPR103W	PRE2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0060066461210859	0.72795697942096	2001	Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome	proteasomal ubiquitin-dependent protein catabolic process|proteasome core complex assembly|proteasomal ubiquitin-independent protein catabolic process	endopeptidase activity	nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YLL018C	DPS1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEUS	0.00599925152705639	0.728395379098129	2002	Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation	cytoplasmic translation|aspartyl-tRNA aminoacylation	RNA binding|aspartate-tRNA ligase activity	nucleus|cytoplasm
YML067C	ERV41	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.00599689609215291	0.728381086559432	2003	Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein	ER to Golgi vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YGL177W_d	YGL177W	hom			0.00599515269722422	0.728456929584809	2004	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHL029C_p	OCA5	hom	FT	SIGNALING|NUCLEOTIDE METABOLISM	0.00598720187547813	0.728802848394269	2005	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts	biological_process	molecular_function	cytoplasm
YBR019C	GAL10	hom	FT	CARBOHYDRATE METABOLISM	0.00598717404792583	0.728804059192995	2006	UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers	galactose catabolic process via UDP-galactose	aldose 1-epimerase activity|UDP-glucose 4-epimerase activity	cytosol
YJL176C	SWI3	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|RSC COMPLEX	0.00597568575035808	0.729303981804836	2007	Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	histone binding|DNA binding	SWI/SNF complex|nucleus
YMR226C	YMR226C	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEUS	0.00596920185461136	0.729586184607835	2008	NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments	metabolic process	oxidoreductase activity|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|carbonyl reductase (NADPH) activity	integral to membrane|ribosome|nucleus|cytoplasm
YFL007W	BLM10	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS	0.00595793236101192	0.730076761197217	2009	Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200	proteasome assembly|regulation of proteasomal protein catabolic process	proteasome binding|peptidase activator activity	proteasome core complex|proteasome complex|integral to membrane|nucleus
YKL043W	PHD1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.00593950166287236	0.730879312784923	2010	Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication	pseudohyphal growth|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YJR004C	SAG1	hom			0.00593614777515238	0.731025387131345	2011	Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YDR101C	ARX1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS|NUCLEUS|RIBOSOME	0.00593565212765646	0.731085524239147	2012	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex	ribosomal large subunit biogenesis	molecular_function	nucleoplasm|cytosolic large ribosomal subunit|cytoplasm
YOL123W	HRP1	het	FT	RNA PROCESSING|NUCLEUS	0.0059310262671082	0.731248466758408	2013	Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences	mRNA cleavage|mRNA polyadenylation	mRNA binding|RNA binding	mRNA cleavage factor complex|nucleus|cytoplasmic stress granule|cytoplasm
YML054C	CYB2	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.00591863476127597	0.731788302597679	2014	Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions	lactate metabolic process	L-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial intermembrane space
YLR151C	PCD1	hom	FT	NUCLEOTIDE METABOLISM	0.00591223439276333	0.732067186594263	2015	Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member	biological_process	pyrophosphatase activity	peroxisome
YLR390W	ECM19	hom	FT	CELL WALL ORG/BIOGENESIS|MITOCHONDRION	0.00590818671781375	0.732320364132607	2016	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	fungal-type cell wall organization	molecular_function	mitochondrion
YDL089W	NUR1	hom	FT	ENDOMEMBRANE SYSTEM|NUCLEUS	0.00589765963537534	0.732855748907896	2017	Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate	maintenance of rDNA	molecular_function	nuclear periphery
YMR036C	MIH1	hom	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0058704200870236	0.733890035177845	2018	Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25	G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	protein tyrosine phosphatase activity	nucleus|cytoplasm
YMR040W	YET2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0058544470965071	0.734624839357189	2019	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein	biological_process	molecular_function	ribosome|integral to membrane
YIL149C	MLP2	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CYTOSKELETON	0.00584972936425714	0.734792579975594	2020	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length	poly(A)+ mRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|regulation of transcription, DNA-dependent|telomere tethering at nuclear periphery|spindle pole body organization|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	ribonucleoprotein complex binding	nucleoplasm|nuclear envelope|mitochondrion|ribonucleoprotein complex|integral to membrane|spindle pole body
YMR243C	ZRC1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.00584057304143649	0.73519210259505	2021	Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication	cobalt ion transport|cellular zinc ion homeostasis|zinc ion transport|glutathione metabolic process	zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity	integral to membrane|fungal-type vacuole
YIL139C	REV7	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0058207025034076	0.736059370417687	2022	Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair	error-prone translesion synthesis|error-free translesion synthesis	DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YER082C	UTP7	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00581534120206193	0.736331284212166	2023	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus|90S preribosome
YLR388W	RPS29A	hom	FT	TRANSLATION|RIBOSOME	0.00581206180934197	0.736436606399645	2024	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YGL213C	SKI8	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEUS|CHROMOSOME	0.00579125348597285	0.737345318001646	2025	Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay|protein-DNA complex assembly|reciprocal meiotic recombination	molecular_function	Ski complex|nuclear chromosome
YMR180C	CTL1	hom	FT	RNA PROCESSING|NUCLEUS	0.00578914524012135	0.737437406829279	2026	RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm	biological_process	polynucleotide 5'-phosphatase activity	nucleus|cytoplasm
YLR258W	GSY2	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.00578786869869497	0.737493168383051	2027	Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress	glycogen biosynthetic process	glycogen (starch) synthase activity	cytoplasm
YLL033W	IRC19	hom			0.00578283996925133	0.73771284548086	2028	Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci	mitotic recombination|ascospore formation	molecular_function	cellular_component
YNR067C	DSE4	hom	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION	0.00578155280584449	0.737769077902665	2029	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother	cytokinesis, completion of separation	glucan endo-1,3-beta-D-glucosidase activity	fungal-type cell wall|extracellular region|cell septum
YOR163W	DDP1	hom	FT	CARBOHYDRATE METABOLISM|NUCLEUS	0.0057813575307157	0.737777609027076	2030	Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress	polyphosphate catabolic process|inositol phosphate dephosphorylation|diadenosine polyphosphate catabolic process	diphosphoinositol-polyphosphate diphosphatase activity|endopolyphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|bis(5'-adenosyl)-hexaphosphatase activity	nucleus|cytoplasm
YGR242W_d	YGR242W	hom			0.00577718335278617	0.737959977047391	2031	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C	Unknown	Unknown	Unknown
YHR130C_d	YHR130C	hom			0.00577564335457354	0.738027262623603	2032	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL028W	YJL028W	hom			0.00577282199949321	0.738150538426823	2033	Protein of unknown function; may interact with ribosomes, based on co-purification experiments	biological_process	molecular_function	ribosome
YPL023C	MET12	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	0.00576583222354462	0.738455977480573	2034	Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR	biological_process	methylenetetrahydrofolate reductase (NADPH) activity	cellular_component
YOR194C	TOA1	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.00576458159149896	0.738510631921864	2035	TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA	transcription initiation from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly	TBP-class protein binding|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly	transcription factor TFIIA complex
YIL128W	MET18	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE|NUCLEUS	0.00574244204012995	0.739590706093149	2036	Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19	methionine metabolic process|nucleotide-excision repair|transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YIL018W	RPL2B	hom	FT	TRANSLATION|RIBOSOME	0.00574240071782881	0.739480187610396	2037	Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YCR076C	FUB1	hom			0.00573945337972229	0.739609050900997	2038	Putative protein of unknown function; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; exhibits boundary activity which blocks the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene	biological_process	proteasome binding	cellular_component
YKL132C	RMA1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.00573093593645573	0.739981490962259	2039	Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	tetrahydrofolylpolyglutamate synthase activity	mitochondrion
YMR152W	YIM1	hom	FT	RESPONSE TO DNA DAMAGE|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.00571217977656828	0.740801851523728	2040	Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	response to DNA damage stimulus	molecular_function	mitochondrion|lipid particle|cytoplasm
YOR238W_p	YOR238W	hom			0.00571206999779245	0.740806653917384	2041	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YHR190W	ERG9	het	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.00570877669487875	0.740950727779558	2042	Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway	ergosterol biosynthetic process	squalene synthase activity|farnesyl-diphosphate farnesyltransferase activity	mitochondrial outer membrane|integral to membrane|endoplasmic reticulum
YMR019W	STB4	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0057026244871564	0.74121989598204	2043	Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;	biological_process	sequence-specific DNA binding|DNA binding	nucleus
YMR178W	YMR178W	hom	FT	COFACTOR METABOLISM|NUCLEUS	0.00569905879973587	0.741375914582227	2044	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YGL209W	MIG2	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|MITOCHONDRION	0.00569802686795496	0.741421069304068	2045	Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	mitochondrion|nucleus
YKR038C	KAE1	het	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|PROTEOLYSIS|NUCLEUS|CHROMOSOME	0.00569339875825732	0.741623594610759	2046	Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription	chromosome organization|threonylcarbamoyladenosine metabolic process|telomere maintenance|positive regulation of transcription from RNA polymerase II promoter	chromatin DNA binding	nuclear chromatin|EKC/KEOPS complex|nucleus|cytoplasm
YGL254W	FZF1	hom	FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS|NUCLEUS	0.00567476577123814	0.742439151870782	2047	Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress	positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YPL068C_p	YPL068C	hom	FT	NUCLEUS	0.00567179770201159	0.742569089610978	2048	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus
YPL034W_p	YPL034W	hom			0.00565550417176299	0.743282527115027	2049	Putative protein of unknown function; YPL034W is not essential gene	biological_process	molecular_function	cellular_component
YKL018W	SWD2	het	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.00565223359725154	0.743425760874459	2050	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination	mRNA 3'-end processing|termination of RNA polymerase II transcription, exosome-dependent|histone H3-K4 methylation|termination of RNA polymerase II transcription, poly(A)-coupled|telomere maintenance|snoRNA 3'-end processing|histone H3-K79 methylation	histone methyltransferase activity (H3-K4 specific)	mRNA cleavage and polyadenylation specificity factor complex|Set1C/COMPASS complex
YMR052C-A_d	YMR052C-A	hom			0.0056484567949559	0.743591175759872	2051	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL188W	KAR1	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	0.00564428312751802	0.74403216626755	2052	Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p	karyogamy involved in conjugation with cellular fusion|spindle pole body duplication associated with nuclear envelope	protein binding	half bridge of spindle pole body
YDL037C	BSC1	hom			0.00564269155195067	0.743843702389467	2053	Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression	biological_process	molecular_function	cellular_component
YNL031C	HHT2	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.00563711484733758	0.744087996946982	2054	Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation	chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint	DNA binding	nuclear nucleosome
YCL023C_d	YCL023C	hom			0.00563639371071529	0.744119589123739	2055	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4	Unknown	Unknown	Unknown
YDR034C	LYS14	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.00561412341535482	0.745132125645256	2056	Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YGL039W	YGL039W	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS	0.00560761045947624	0.745527539596839	2057	Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols	cellular ketone metabolic process|cellular aromatic compound metabolic process	oxidoreductase activity, acting on CH-OH group of donors|carbonyl reductase (NADPH) activity	cytoplasm
YJL070C_p	YJL070C	hom	FT	NUCLEOTIDE METABOLISM|MITOCHONDRION	0.00560304814210649	0.745727421176206	2058	Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication	biological_process	AMP deaminase activity|molecular_function	mitochondrion|cytoplasm
YPR178W	PRP4	het	FT	RNA PROCESSING|NUCLEUS	0.00559304368009345	0.746129207381523	2059	Splicing factor, component of the U4/U6-U5 snRNP complex	mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YER091C-A_d	YER091C-A	hom			0.00558841637185439	0.746222386410359	2060	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR059C	REX2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00558223612851225	0.746493397876325	2061	3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease	U5 snRNA 3'-end processing|U4 snRNA 3'-end processing|mitochondrial genome maintenance|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3'-5'-exoribonuclease activity|3'-5' exonuclease activity	mitochondrion
YLR028C	ADE16	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.00556568436739275	0.747219367771049	2062	Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine	ascospore formation|'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process|aerobic respiration	phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity	cytosol
YCR087W_d	YCR087W	hom			0.00555321281720007	0.747766525388024	2063	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene	Unknown	Unknown	Unknown
YMR254C_d	YMR254C	hom			0.00555185394596278	0.747826150095054	2064	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR521W_d	YDR521W	hom			0.00555104582430677	0.747970585004405	2065	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol	Unknown	Unknown	Unknown
YOR363C	PIP2	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS	0.00554851466482156	0.747972677858477	2066	Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication	cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	integral to membrane|nucleus
YIL168W	YIL168W	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0055434139093024	0.748269071408766	2067	Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase	serine family amino acid metabolic process	L-serine ammonia-lyase activity	cellular_component
YGL133W	ITC1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS	0.00554256596830385	0.748233729395955	2068	Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex	negative regulation of transcription from RNA polymerase II promoter by pheromones|chromatin remodeling|chromatin silencing at telomere	molecular_function	chromatin accessibility complex
YPL183W-A	RTC6	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.00553486909807775	0.748571540291352	2069	Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress	mitochondrial translation|ribosome biogenesis	structural constituent of ribosome	mitochondrial large ribosomal subunit
YIL025C_d	YIL025C	hom			0.0055190732852661	0.749264959822667	2070	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER074W	RPS24A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS|MITOCHONDRION|RIBOSOME	0.00551821487051454	0.749302649136277	2071	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|mitochondrion
YPR083W	MDM36	hom	FT	MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00551807909800619	0.749344735914051	2072	Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission	mitochondrial fission|mitochondrion organization	molecular_function	mitochondrion|cytoplasm
YLR361C	DCR2	hom	FT	CELL CYCLE|SIGNALING	0.00551105882819705	0.749652947830651	2073	Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START	endoplasmic reticulum unfolded protein response|traversing start control point of mitotic cell cycle|protein dephosphorylation	hydrolase activity, acting on ester bonds|phosphoprotein phosphatase activity|phosphoric ester hydrolase activity	cellular_component
YOR283W	YOR283W	hom	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.00549808389306197	0.750186685502994	2074	Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene	dephosphorylation	phosphatase activity	nucleus|cytoplasm
YPR108W	RPN7	het	FT	PROTEOLYSIS|NUCLEUS	0.00549581327747874	0.750394419860669	2075	Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits	ubiquitin-dependent protein catabolic process	structural molecule activity	nucleus|proteasome regulatory particle, lid subcomplex
YMR192W	GYL1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.00549406157694376	0.750399346020542	2076	Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress	ER to Golgi vesicle-mediated transport|regulation of exocytosis	protein binding	mitochondrion|incipient cellular bud site|cellular bud|cellular bud neck|cellular bud tip|cytoplasm|Golgi-associated vesicle|plasma membrane
YPR072W	NOT5	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.00547697533801333	0.751114003753585	2077	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation	deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination	ubiquitin-protein ligase activity	CCR4-NOT core complex|cytoplasm
YOR306C	MCH5	hom	FT	PLASMA MEMBRANE	0.00546440030088567	0.751702417117908	2078	Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport	riboflavin transport	monocarboxylic acid transmembrane transporter activity|riboflavin transporter activity	integral to membrane|plasma membrane
YJL168C	SET2	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.00546172151992551	0.751784341817016	2079	Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p	negative regulation of histone H3-K14 acetylation|DNA-dependent transcription, elongation|ascospore formation|regulation of transcription, DNA-dependent|histone deacetylation|regulation of DNA-dependent DNA replication initiation|histone methylation|negative regulation of antisense RNA transcription|Unknown|negative regulation of reciprocal meiotic recombination|positive regulation of histone acetylation	histone methyltransferase activity|histone methyltransferase activity (H3-K36 specific)	nucleus
YKL090W	CUE2	hom			0.0054465624393074	0.752450702078364	2080	Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination	biological_process	ubiquitin binding	cellular_component
YOR291W	YPK9	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	0.00540877634699445	0.754254457088917	2081	Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YKL164C	PIR1	hom	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	0.00540653100498981	0.754211282462962	2082	O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication	intracellular protein transport|fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall
YLR011W	LOT6	hom	FT	PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.00540449895053028	0.754300686260426	2083	FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions	cellular response to oxidative stress|cytoplasmic sequestering of transcription factor	NAD(P)H dehydrogenase (quinone) activity|transcription factor binding	cytosol|nucleus|cytoplasm
YER112W	LSM4	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00539658262988289	0.754684418787967	2084	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|cytoplasmic mRNA processing body assembly	U6 snRNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|cytoplasmic mRNA processing body|U4/U6 x U5 tri-snRNP complex
YDR210W_p	YDR210W	hom	FT	PLASMA MEMBRANE	0.00539420920081347	0.754753452340577	2085	Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YLL024C	SSA2	hom	FT	PROTEIN LOCALIZATION|MITOCHONDRION	0.00538612532173702	0.75514456236511	2086	ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity|ATP binding	cytosol|fungal-type vacuole membrane|mitochondrion|fungal-type cell wall|plasma membrane|polysome|chaperonin-containing T-complex|cytoplasm
YJR111C_p	YJR111C	hom	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.00536917770965949	0.755855231002699	2087	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria	biological_process	molecular_function	mitochondrion
YDR266C	HEL2	hom			0.00535809763933384	0.756343086725011	2088	RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor	biological_process	molecular_function	ribosome|cytoplasm
YGL005C	COG7	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS	0.00535623033274902	0.756742047061255	2089	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	mitochondrion|Golgi transport complex
YLR139C	SLS1	hom	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0053491934617203	0.756735208222751	2090	Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery	aerobic respiration|mitochondrial translation	molecular_function	mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YJR062C	NTA1	hom	FT	PROTEOLYSIS|MITOCHONDRION	0.00534388462336972	0.756969028242555	2091	Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation	cellular protein modification process|protein catabolic process	protein-N-terminal asparagine amidohydrolase activity	mitochondrion
YKL005C	BYE1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.00534084782813601	0.757243136759684	2092	Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit	negative regulation of transcription from RNA polymerase II promoter	methylated histone residue binding	nucleus
YOL053W	AIM39	hom	FT	MITOCHONDRION	0.00533109021253449	0.75753263068866	2093	Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YNL310C	ZIM17	het	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00532550249330522	0.757778813947314	2094	Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix	protein folding|protein stabilization|protein import into mitochondrial matrix|response to unfolded protein|mitochondrion organization	chaperone binding	mitochondrion|mitochondrial matrix
YNR039C	ZRG17	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00532532032114924	0.757786840486171	2095	Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency	zinc ion transport	zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YIL098C	FMC1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00532085413648905	0.757983629569872	2096	Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p	mitochondrial proton-transporting ATP synthase complex assembly	molecular_function	mitochondrion|mitochondrial matrix
YJR120W	YJR120W	hom	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.00532004048527402	0.758194312284857	2097	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p	cellular respiration|sterol transport|mitochondrion organization	molecular_function	cellular_component
YBL041W	PRE7	het	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0053074168511062	0.75892484903839	2098	Beta 6 subunit of the 20S proteasome	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YPL223C	GRE1	hom			0.00530716821891147	0.75858675621084	2099	Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway	biological_process	molecular_function	cytoplasm
YJL024C	APS3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00530272210777487	0.75878272413467	2100	Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress	Golgi to vacuole transport|vesicle-mediated transport	molecular_function	AP-3 adaptor complex
YDR051C	DET1	hom	FT	NUCLEUS	0.00528775330240513	0.759442606783302	2101	Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel	intracellular sterol transport|dephosphorylation	acid phosphatase activity	nucleus|cytoplasm
YKL044W_p	YKL044W	hom			0.00528588465787299	0.759524996141626	2102	Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YGR157W	CHO2	hom	FT	LIPID METABOLISM	0.00528139749796055	0.760035572746211	2103	Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis	phosphatidylcholine biosynthetic process	phosphatidylethanolamine N-methyltransferase activity	integral to membrane|endoplasmic reticulum
YBR009C	HHF1	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.00528001232672877	0.75978392755412	2104	Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity	chromatin assembly or disassembly|sexual sporulation resulting in formation of a cellular spore|histone H3-K79 methylation	DNA binding	replication fork protection complex|nuclear nucleosome
YIL129C	TAO3	het	FT	CELL DIVISION|MITOCHONDRION|SITE OF POLARIZED GROWTH	0.00527432585741585	0.760034689324386	2105	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p	cell morphogenesis|cell budding|budding cell apical bud growth	molecular_function	incipient cellular bud site|mitochondrion|cellular bud|mating projection tip
YPR059C_d	YPR059C	hom			0.00526338568140545	0.760690341734751	2106	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W	Unknown	Unknown	Unknown
YGR085C	RPL11B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.00525167557253582	0.761275719714667	2107	Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome	cytosolic large ribosomal subunit
YPR017C	DSS4	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	0.00524636583209941	0.761268036048379	2108	Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol	post-Golgi vesicle-mediated transport	zinc ion binding|guanyl-nucleotide exchange factor activity	cytosol|membrane
YDR182W-A_p	YDR182W-A	hom			0.00524425122621725	0.76136133829344	2109	Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YPR066W	UBA3	hom			0.00524030065285415	0.76153565778038	2110	Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	protein neddylation	NEDD8 activating enzyme activity	cytoplasm
YOL146W	PSF3	het	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0052347982348426	0.761778472741257	2111	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery	double-strand break repair via break-induced replication|DNA-dependent DNA replication	molecular_function	replication fork protection complex|GINS complex|DNA replication preinitiation complex
YDR382W	RPP2B	hom	FT	TRANSLATION|RIBOSOME	0.00520919415924028	0.762908657230209	2112	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	translational elongation|cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YJL003W	COX16	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0052075035011903	0.762983302049023	2113	Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion|mitochondrial inner membrane
YHR133C	NSG1	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00520352541774541	0.763158948453722	2114	Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; forms foci at the nuclear periphery upon DNA replication stress	sterol biosynthetic process	unfolded protein binding	integral to membrane|endoplasmic reticulum
YPL125W	KAP120	hom	FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.00518736323208503	0.763872691176087	2115	Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p	protein import into nucleus|transcription factor import into nucleus	protein transporter activity|structural constituent of nuclear pore	integral to membrane|nucleus|nuclear pore|cytoplasm
YNL067W-B_p	YNL067W-B	hom			0.00518614192780208	0.76392663368986	2116	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR172C	DPH5	hom			0.0051844966346837	0.764101757561716	2117	Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	diphthine synthase activity	cytoplasm
YPL152W	RRD2	hom	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	0.00517852503746114	0.764263082002659	2118	Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress	mitotic spindle organization in nucleus|response to osmotic stress	peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity	protein phosphatase type 2A complex
YNR044W	AGA1	hom			0.00517143647966168	0.76457623312283	2119	Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YNR051C	BRE5	hom	FT	VESICLE-MEDIATED TRANSPORT	0.0051627816552873	0.764958629351701	2120	Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown	molecular_function	cytoplasm
YKR029C	SET3	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.00514868115631082	0.765581754540221	2121	Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication	negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation	methylated histone residue binding	Rpd3L-Expanded complex|Set3 complex
YER169W	RPH1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS	0.00514229096604331	0.765864197949927	2122	JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|histone demethylation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)	nucleus
YKL114C	APN1	hom	FF|FT	RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION	0.0051231056711237	0.766712365765505	2123	Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine	base-excision repair	3'-tyrosyl-DNA phosphodiesterase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity	mitochondrion|nucleus
YOL019W_p	YOL019W	hom	FT	PLASMA MEMBRANE	0.00511642218394103	0.767007903522204	2124	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; YOL019W has a paralog, DCV1, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane|plasma membrane|fungal-type vacuole
YCR028C	FEN2	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PLASMA MEMBRANE	0.00511333890307003	0.767144254834921	2125	Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress	pantothenate transmembrane transport|endocytosis	pantothenate transmembrane transporter activity	integral to membrane|plasma membrane
YGL166W	CUP2	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.00510456549047	0.767633291513056	2126	Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter|response to copper ion	RNA polymerase II core promoter proximal region sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|copper ion binding	nucleus
YPL222W_p	FMP40	hom	FT	MITOCHONDRION	0.00509607690939379	0.768075887213963	2127	Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YHR122W	CIA2	het	FT	CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS	0.00509450852557498	0.767977143097258	2128	Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B	establishment of mitotic sister chromatid cohesion	molecular_function	nucleus|cytoplasm
YBR205W	KTR3	hom	FT	CARBOHYDRATE METABOLISM	0.00508417257424324	0.768467970022572	2129	Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress	N-glycan processing|protein O-linked glycosylation	mannosyltransferase activity	fungal-type vacuole
YGR161C_p	RTS3	hom	FT	NUCLEUS	0.00508330923248752	0.76847262721514	2130	Putative component of the protein phosphatase type 2A complex	biological_process	molecular_function	nucleus|cytoplasm
YLR414C	PUN1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|PLASMA MEMBRANE	0.00505169080725806	0.769872013415822	2131	Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress	fungal-type cell wall organization|protein oligomerization	molecular_function	integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YDR113C	PDS1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CYTOSKELETON	0.00504099885221914	0.77047855441173	2132	Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation	protein localization|recombinational repair|meiosis I|mitotic sister chromatid segregation	enzyme binding	nucleus|cytoplasm|spindle
YEL033W_p	MTC7	hom			0.0050229926832352	0.771375125815138	2133	Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant	biological_process	molecular_function	cellular_component
YIL009W	FAA3	hom	FT	KETONE METABOLISM|LIPID METABOLISM	0.00502174952678036	0.77119786254203	2134	Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	long-chain fatty acid metabolic process	long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity	cellular_component
YOR303W	CPA1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.00501826348564281	0.771352273686605	2135	Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader	arginine biosynthetic process	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carbamoyl-phosphate synthase complex
YLR319C	BUD6	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.00500256849762301	0.772047581534539	2136	Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate	bipolar cellular bud site selection|positive regulation of formin-nucleated actin cable assembly|cellular bud site selection|Rho protein signal transduction|extrachromosomal circular DNA localization involved in cell aging|establishment of cell polarity|response to osmotic stress|cytokinesis	cytoskeletal regulatory protein binding	polarisome|actin cap|spindle pole body|mating projection tip
YKL156W	RPS27A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.00497955919032608	0.773100164052773	2137	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasm
YGR030C	POP6	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00497711154727514	0.773175745623351	2138	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YGR098C	ESP1	het	FT	CELL CYCLE|LIPID METABOLISM|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CYTOSKELETON	0.00496499337307553	0.773712949742363	2139	Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress	regulation of exit from mitosis|regulation of mitotic spindle elongation|negative regulation of protein phosphatase type 2A activity|apoptotic process|mitotic sister chromatid segregation	cysteine-type endopeptidase activity	mitochondrion|nucleus|cytoplasm|spindle
YHR086W	NAM8	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS|MITOCHONDRION	0.00495075983206052	0.774344067386117	2140	RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function	mRNA splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|mRNA splice site selection	mRNA binding|RNA binding	commitment complex|U1 snRNP|U2-type prespliceosome
YBR024W	SCO2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.00494180679181331	0.774741123133103	2141	Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication	copper ion transport	thioredoxin peroxidase activity	mitochondrial envelope|mitochondrion
YER091C	MET6	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.00493321694574228	0.775220030469013	2142	Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs	methionine biosynthetic process	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	plasma membrane|cytoplasm
YPR064W_d	YPR064W	hom			0.00493071340974899	0.775233181951499	2143	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL078C	MDH3	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	0.0049202675383466	0.775696602228355	2144	Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle	glyoxylate cycle|fatty acid beta-oxidation|malate metabolic process|NADH regeneration	L-malate dehydrogenase activity|mRNA binding	peroxisomal matrix|peroxisome
YBR225W_p	YBR225W	hom			0.00491124973223302	0.776096732091424	2145	Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components	biological_process	molecular_function	cellular_component
YOL093W	TRM10	hom	FT	RNA PROCESSING|NUCLEUS	0.00490655320123604	0.776305145811721	2146	tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress	tRNA methylation	tRNA (guanine) methyltransferase activity	nucleus|cytoplasm
YDR119W_p	VBA4	hom			0.00490478948536602	0.776643214586703	2147	Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YDR018C_p	YDR018C	hom	FT	LIPID METABOLISM	0.0049036649262602	0.776433324181162	2148	Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication	phospholipid biosynthetic process	transferase activity, transferring acyl groups	integral to membrane
YGL037C	PNC1	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING|NUCLEUS	0.00489430211080114	0.776848877139334	2149	Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress	replicative cell aging|chromatin silencing at rDNA|nicotinate nucleotide salvage|chromatin silencing at telomere	nicotinamidase activity	nucleus|peroxisome|cytoplasm
YDR492W	IZH1	hom	FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0048696314817393	0.777944147309375	2150	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc	response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process	metal ion binding	integral to membrane|endoplasmic reticulum|membrane
YGR059W	SPR3	hom	FT	CELL CYCLE|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.00485826388504441	0.778448968466197	2151	Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI	ascospore formation	structural molecule activity	septin complex|ascospore wall|prospore membrane
YDL109C_p	YDL109C	hom	FT	LIPID METABOLISM	0.00485452937986136	0.778614833709533	2152	Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication	cellular lipid metabolic process	molecular_function	cellular_component
YIL064W	SEE1	hom	FT	VESICLE-MEDIATED TRANSPORT	0.00485043937799386	0.77879649963594	2153	Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport	vesicle-mediated transport|peptidyl-lysine dimethylation	protein-lysine N-methyltransferase activity	cytoplasm
YPR132W	RPS23B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0048429532207463	0.779129044142847	2154	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity	structural constituent of ribosome	cytosolic small ribosomal subunit
YLR073C	RFU1	hom			0.00484010644056522	0.779255512303846	2155	Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes	regulation of ubiquitin homeostasis	enzyme inhibitor activity	endosome
YHR157W	REC104	hom	FT	CELL CYCLE|NUCLEUS|CHROMOSOME	0.00483562646219122	0.779454547094929	2156	Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YNL105W_d	RRT16	hom			0.00482445185978189	0.779951071084346	2157	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription	Unknown	Unknown	Unknown
YLR374C_d	YLR374C	hom			0.00480565125589425	0.781041602844963	2158	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W	Unknown	Unknown	Unknown
YJL130C	URA2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|MITOCHONDRION	0.00478830264442339	0.781557912203203	2159	Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP	glutamine metabolic process|'de novo' pyrimidine nucleobase biosynthetic process|negative regulation of pyrimidine nucleobase metabolic process	aspartate carbamoyltransferase activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	mitochondrion|integral to membrane|cytoplasm
YCR015C_p	YCR015C	hom			0.00478275528324854	0.781804576411252	2160	Putative protein of unknown function; YCR015C is not an essential gene	biological_process	molecular_function	cellular_component
YLR102C	APC9	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.00477857013461655	0.781990684164031	2161	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	chromatin assembly|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YPR043W	RPL43A	hom	FT	TRANSLATION|RIBOSOME	0.00477406824462025	0.782190890894413	2162	Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YER109C	FLO8	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|NUCLEUS	0.00476754103929509	0.782481192467861	2163	Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene	biofilm formation|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YBR107C	IML3	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE	0.00473293078860899	0.784021010294178	2164	Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1	establishment of meiotic sister chromatid cohesion|ascospore formation|protein localization to chromosome, centromeric region|meiotic sister chromatid segregation|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome outer kinetochore
YFR055W_p	IRC7	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.00473220684654924	0.784053227689127	2165	Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner	sulfur compound metabolic process|L-cysteine catabolic process to pyruvate	cysteine-S-conjugate beta-lyase activity	cellular_component
YOL070C	NBA1	hom	FT	SITE OF POLARIZED GROWTH	0.00472912814764065	0.784221625210607	2166	Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate	biological_process	molecular_function	ribosome|cellular bud neck|cytoplasm
YLR119W	SRN2	hom	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT	0.0047265152534816	0.784306531978897	2167	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	protein binding	endosome|ESCRT I complex
YJL077W-B_p	YJL077W-B	hom			0.00472127006106427	0.784539989438724	2168	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YPL180W	TCO89	hom	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PLASMA MEMBRANE	0.00472098960109738	0.78455247293412	2169	Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin	TOR signaling cascade|fungal-type cell wall organization|response to salt stress|regulation of cell growth|glycerol metabolic process	molecular_function	TORC1 complex|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|extrinsic to vacuolar membrane
YDR050C	TPI1	het	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.00471208062144618	0.784980325701758	2170	Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease	glycolysis	triose-phosphate isomerase activity	mitochondrion|plasma membrane|cytoplasm
YCL042W_p	YCL042W	hom			0.00470735929990217	0.785221738561167	2171	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YPR045C	THP3	hom	FT	RNA PROCESSING|NUCLEUS|CHROMOSOME	0.00470612800245302	0.785214053648583	2172	Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes	mRNA splicing, via spliceosome	molecular_function	nucleus|transcriptionally active chromatin
YDR234W	LYS4	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.00470252054968556	0.785374666864588	2173	Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway	lysine biosynthetic process via aminoadipic acid	homoaconitate hydratase activity	mitochondrion
YKL061W_p	BLI1	hom			0.00468845668985369	0.786125475621897	2174	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YJR141W_p	YJR141W	het			0.0046774272424766	0.786492138792871	2175	Essential protein of unknown function	biological_process	molecular_function	cellular_component
YOL066C	RIB2	het	FT	RNA PROCESSING	0.00466855235561045	0.786980512923551	2176	Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs	riboflavin biosynthetic process|tRNA pseudouridine synthesis	pseudouridine synthase activity|2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity	cytoplasm
YDL203C	ACK1	hom	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|MITOCHONDRION	0.00466050884189716	0.787245808639271	2177	Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria	fungal-type cell wall organization|positive regulation of signal transduction	molecular_function	mitochondrion
YBR065C	ECM2	hom	FT	RNA PROCESSING|NUCLEUS	0.00464294321864749	0.788028521332266	2178	Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p	mRNA splicing, via spliceosome	molecular_function	nucleus
YKR042W	UTH1	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|GENE SILENCING|MITOCHONDRION	0.00464170280891501	0.788083801277933	2179	Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication	mitochondrion degradation|fungal-type cell wall biogenesis|negative regulation of chromatin silencing involved in replicative cell aging	molecular_function	mitochondrial outer membrane|fungal-type cell wall
YOL082W	ATG19	hom	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT	0.00462451327049111	0.789065254392027	2180	Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles	vesicle organization|ER-associated protein catabolic process|protein processing|protein complex localization|CVT pathway	protein binding, bridging	pre-autophagosomal structure|cytoplasm|CVT complex|extrinsic to membrane
YKL196C	YKT6	het	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|MITOCHONDRION|GOLGI APPARATUS|PLASMA MEMBRANE	0.0046235084624622	0.788894770715514	2181	Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus	intra-Golgi vesicle-mediated transport|vacuole fusion, non-autophagic|vesicle fusion	palmitoyltransferase activity|SNAP receptor activity	SNARE complex|endosome|mitochondrion|Golgi apparatus|fungal-type vacuole|membrane
YER018C	SPC25	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE	0.0046191064063463	0.789091016222544	2182	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering	microtubule nucleation|chromosome segregation	structural constituent of cytoskeleton	Ndc80 complex|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region
YGR191W	HIP1	het	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.00461600128259619	0.789229451987274	2183	High-affinity histidine permease, also involved in the transport of manganese ions	manganese ion transport|histidine transport	high affinity L-histidine transmembrane transporter activity	integral to membrane|plasma membrane
YIL020C	HIS6	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.00460363083506428	0.789781029771358	2184	Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts	histidine biosynthetic process	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	intracellular
YKR044W	UIP5	hom	FT	ENDOMEMBRANE SYSTEM|NUCLEUS	0.00459585255164352	0.790127904497261	2185	Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates	biological_process	molecular_function	nuclear envelope
YKL054C	DEF1	hom	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS|CHROMOSOME	0.00459265808479086	0.790545431441618	2186	RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis	transcription-coupled nucleotide-excision repair|telomere maintenance|response to DNA damage stimulus|ubiquitin-dependent protein catabolic process	molecular_function	nucleus
YLR428C_d	YLR428C	hom			0.00458087543917855	0.79079593004054	2187	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1	Unknown	Unknown	Unknown
YOR043W	WHI2	hom	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	0.00456801866063955	0.79136950471075	2188	Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression	response to salt stress|mitochondrion degradation|actin filament organization|endocytosis|response to heat|regulation of growth|response to stress	phosphatase activator activity	cellular_component
YHR204W	MNL1	hom	FT	PROTEOLYSIS|ENDOPLASMIC RETICULUM	0.0045660967951001	0.791455253891301	2189	Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation	ER-associated protein catabolic process	carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum lumen
YHR142W	CHS7	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00455812176613738	0.791993153053025	2190	Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress	protein folding|ER to Golgi vesicle-mediated transport|fungal-type cell wall chitin biosynthetic process	unfolded protein binding	integral to membrane|endoplasmic reticulum membrane
YAL037C-A_p	YAL037C-A	hom			0.0045577755276606	0.791826558626491	2191	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR146W_d	YOR146W	het			0.00455236384201162	0.792158953451057	2192	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C	Unknown	Unknown	Unknown
YKR049C	FMP46	hom	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.00453402257663352	0.792916882105917	2193	Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	oxidoreductase activity	mitochondrion
YDR332W	IRC3	hom	FT	MITOCHONDRION	0.00450216975398612	0.794308961452609	2194	Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	ATP-dependent RNA helicase activity	mitochondrion
YML043C	RRN11	het	FT	NUCLEUS	0.00448885597540015	0.794903637231981	2195	Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p	transcription initiation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	TBP-class protein binding|RNA polymerase I CORE element sequence-specific DNA binding|RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity	RNA polymerase I core factor complex
YGR130C	YGR130C	hom			0.00448869386340355	0.795000587847338	2196	Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)	biological_process	molecular_function	eisosome|membrane raft|cytoplasm
YDR444W_p	YDR444W	hom	FT	LIPID METABOLISM	0.00448739818356478	0.794968758483786	2197	Putative hydrolase acting on ester bonds	biological_process	molecular_function	cytoplasm
YBR226C_d	YBR226C	hom			0.00448610732207061	0.795026423955773	2198	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W	Unknown	Unknown	Unknown
YFL038C	YPT1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS	0.00446015770772019	0.796185884311161	2199	Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)	Golgi vesicle budding|Golgi vesicle docking|early endosome to Golgi transport|macroautophagy|endocytic recycling|protein complex assembly|CVT pathway|retrograde vesicle-mediated transport, Golgi to ER|SNARE complex disassembly|ER to Golgi vesicle-mediated transport|COPII-coated vesicle budding	SNARE binding|GTPase activity	trans-Golgi network|mitochondrion|Golgi stack|endoplasmic reticulum membrane|Golgi membrane|pre-autophagosomal structure
YDL235C	YPD1	het	FT	SIGNALING|NUCLEUS	0.00445689193393551	0.796331834983677	2200	Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus	osmosensory signaling pathway via two-component system	protein histidine kinase binding|transferase activity, transferring phosphorus-containing groups	nucleus|cytoplasm
YKR074W	AIM29	hom			0.00445206064381105	0.796696162926253	2201	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cytoplasm
YLL063C	AYT1	hom			0.00444900310759436	0.796684423832259	2202	Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis	secondary metabolic process	trichothecene 3-O-acetyltransferase activity	cellular_component
YML115C	VAN1	hom	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.00444872859542082	0.796696693823031	2203	Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YJL164C	TPK1	hom	FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.00444868356772433	0.796698706450485	2204	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication	protein phosphorylation|Ras protein signal transduction	cAMP-dependent protein kinase activity|protein kinase activity	cAMP-dependent protein kinase complex|nucleus|cytoplasm
YBR040W	FIG1	hom	FT	SITE OF POLARIZED GROWTH	0.00443981379645969	0.797095189779758	2205	Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating	cell morphogenesis involved in conjugation with cellular fusion|cytogamy	molecular_function	fungal-type cell wall|integral to membrane|mating projection tip
YPR055W	SEC8	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.00442156741669665	0.797910976800764	2206	Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress	Golgi inheritance|endoplasmic reticulum inheritance|Golgi to plasma membrane transport|exocytosis|vesicle fusion|vesicle docking involved in exocytosis	molecular_function	incipient cellular bud site|cellular bud neck|mating projection tip|exocyst|cellular bud tip
YCL050C	APA1	hom	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.0044110153148085	0.798382857045983	2207	AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication	nucleotide biosynthetic process|nucleoside catabolic process	bis(5'-nucleosyl)-tetraphosphatase activity|sulfate adenylyltransferase (ADP) activity	nucleus|cytoplasm
YDR185C	UPS3	hom	FT	MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00438913690915406	0.799361473535345	2208	Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations	mitochondrion morphogenesis	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YGL003C	CDH1	hom	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.00438794339065954	0.799473415080196	2209	Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p	activation of mitotic anaphase-promoting complex activity|negative regulation of spindle pole body separation|positive regulation of mitotic metaphase/anaphase transition|Unknown|regulation of cell size	anaphase-promoting complex binding|cyclin binding|ubiquitin-protein ligase activator activity	nucleus|anaphase-promoting complex|cytoplasm
YPL174C	NIP100	hom	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.00437967496719333	0.799960187839213	2210	Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)	establishment of mitotic spindle orientation	microtubule binding	dynactin complex|cell cortex|spindle pole body|astral microtubule
YDR509W_d	YDR509W	hom			0.00437782018693596	0.799867791865671	2211	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR117W	STE24	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.00437333857867371	0.800068325514106	2212	Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans	CAAX-box protein processing|peptide pheromone maturation	metalloendopeptidase activity	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|integral to membrane|nuclear inner membrane
YPR097W	YPR097W	hom	FT	MITOCHONDRION	0.00437150199547607	0.800150508910746	2213	Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	phosphatidylinositol binding	mitochondrion
YKL218C	SRY1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.00433251634663201	0.80206917543231	2214	3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity	cellular modified amino acid catabolic process	serine racemase activity|threo-3-hydroxyaspartate ammonia-lyase activity	cellular_component
YOL060C	MAM3	hom	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	0.00433090470078215	0.801967719274919	2215	Protein required for normal mitochondrial morphology, has similarity to hemolysins	cellular manganese ion homeostasis|mitochondrion organization	molecular_function	fungal-type vacuole membrane|integral to membrane
YKL064W	MNR2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.00430573735685339	0.803094794894698	2216	Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations	cellular magnesium ion homeostasis	magnesium ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YDL125C	HNT1	hom	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.00430235099585361	0.803246478472565	2217	Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress	nucleotide metabolic process	hydrolase activity|nucleotide binding	nucleus|cytoplasm
YGL006W-A_p	YGL006W-A	hom			0.00429480433531582	0.803584538912951	2218	Putative protein of unknown function; identified by SAGE	biological_process	molecular_function	cellular_component
YLR307W	CDA1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.00428551265121011	0.804201327356482	2219	Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall	ascospore wall assembly	chitin deacetylase activity	chitosan layer of spore wall
YJL035C	TAD2	het	FT	RNA PROCESSING|NUCLEUS	0.00428094561912555	0.804205450011757	2220	Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs	tRNA modification	tRNA-specific adenosine deaminase activity	nucleus|cytoplasm
YDR195W	REF2	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.00426031727877291	0.805129888711932	2221	RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes	mRNA 3'-end processing|termination of RNA polymerase II transcription, poly(A)-coupled|snoRNA 3'-end processing|Unknown	chromatin binding|RNA binding	mRNA cleavage and polyadenylation specificity factor complex|nucleus
YPL234C	VMA11	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.00425862659316647	0.805205667210915	2222	Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane|fungal-type vacuole
YNL273W	TOF1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.00425730111794926	0.805378918163227	2223	Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase	DNA repair|DNA replication checkpoint|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|DNA replication|mitotic sister chromatid cohesion	molecular_function	nuclear chromosome|replication fork protection complex|nuclear replication fork
YJL188C_d	BUD19	hom			0.0042488471918014	0.805644027239872	2224	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant