Strain	Gene	Zyg	FClass	FTerms	similarity score	p-value	rank	description	GOBP	GOMF	GOCC
YOR219C	STE13	hom	FT	PROTEOLYSIS|GOLGI APPARATUS	1	0	1	Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor	peptide pheromone maturation	aminopeptidase activity	trans-Golgi network
YJL171C	YJL171C	hom	FT	MITOCHONDRION|PLASMA MEMBRANE	0.130996458413224	2.56087372308661e-14	2	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrion|fungal-type cell wall|plasma membrane
YGR189C	CRH1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.118362062246821	6.04994822332441e-12	3	Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress	fungal-type cell wall organization|cell wall chitin metabolic process	transferase activity, transferring glycosyl groups	incipient cellular bud site|fungal-type cell wall
YDR215C_d	YDR215C	hom			0.116951483852169	1.10689660557985e-11	4	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein	Unknown	Unknown	Unknown
YGR100W	MDR1	hom	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM	0.0994251234534282	7.83562848680249e-09	5	Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function	intracellular protein transport	Rab GTPase activator activity	cytoplasm
YOL099C_d	YOL099C	hom			0.0993680082016746	7.99212094299953e-09	6	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes	Unknown	Unknown	Unknown
YJR153W	PGU1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.0976826662395265	1.42539067397218e-08	7	Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins	pseudohyphal growth|pectin catabolic process	polygalacturonase activity	extracellular region
YLL054C_p	YLL054C	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0908312993326687	1.35767265488316e-07	8	Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene	biological_process	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	cellular_component
YDL238C	GUD1	hom			0.0903669652750997	1.57277755952894e-07	9	Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures	guanine metabolic process	guanine deaminase activity|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	cytoplasm
YPL185W_d	YPL185W	hom			0.0901829468058243	1.66683970843581e-07	10	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C	Unknown	Unknown	Unknown
YDR497C	ITR1	hom	FT	PLASMA MEMBRANE	0.0901094587980025	1.70590318996691e-07	11	Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress	myo-inositol transport|transmembrane transport	myo-inositol transmembrane transporter activity	integral to membrane|plasma membrane|membrane
YLR128W	DCN1	hom			0.0873704588081668	3.99348625107136e-07	12	Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation	protein neddylation|positive regulation of ubiquitin-protein ligase activity	ubiquitin binding|NEDD8 ligase activity|small conjugating protein binding	cellular_component
YDL146W	LDB17	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0867471659805773	4.82946631359013e-07	13	Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck	endocytosis	molecular_function	cellular bud|cellular bud neck|cytoplasm|actin cortical patch
YNL166C	BNI5	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0864105783431111	5.60400402692276e-07	14	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner	septin ring assembly|cytokinesis	molecular_function	cellular bud neck septin ring|cellular bud neck
YGR022C_d	YGR022C	hom			0.0847553082332726	8.78899226922343e-07	15	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W	Unknown	Unknown	Unknown
YDR521W_d	YDR521W	hom			0.0845408290970741	9.47223183040468e-07	16	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol	Unknown	Unknown	Unknown
YDR051C	DET1	hom	FT	NUCLEUS	0.0841799823927908	1.04228195612171e-06	17	Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel	intracellular sterol transport|dephosphorylation	acid phosphatase activity	nucleus|cytoplasm
YDL230W	PTP1	hom	FT	MITOCHONDRION	0.0827793546215644	1.57130501166506e-06	18	Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation	pseudohyphal growth|invasive growth in response to glucose limitation|protein dephosphorylation	protein tyrosine phosphatase activity	mitochondrion|cytoplasm
YDL157C_p	YDL157C	hom	FT	MITOCHONDRION	0.079833223208337	3.64806851202666e-06	19	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YKL198C	PTK1	hom	FT	PROTEIN PHOSPHORYLATION	0.0777184419690272	6.56120271136177e-06	20	Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein	polyamine transport	protein kinase activity	cellular_component
YNL085W	MKT1	hom	FT	RESPONSE TO DNA DAMAGE|TRANSLATION	0.077205807247358	7.54772495007875e-06	21	Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress	positive regulation of translation|interspecies interaction between organisms|response to DNA damage stimulus	nuclease activity	polysome|cytoplasm
YJR037W_d	YJR037W	hom			0.076620555492477	9.06801616440343e-06	22	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces	Unknown	Unknown	Unknown
YLR213C	CRR1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.0763029688059191	9.63922045610568e-06	23	Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation	ascospore wall assembly	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	ascospore wall
YLL042C	ATG10	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.0761325733034529	1.00915990494261e-05	24	Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy	piecemeal microautophagy of nucleus|cellular protein modification process|mitochondrion degradation|macroautophagy|CVT pathway	Atg12 ligase activity	cellular_component
YLR412C-A_p	YLR412C-A	hom			0.0756194801742876	1.15794374215742e-05	25	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR490C	PKH1	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	0.0755529075150099	1.19294153622425e-05	26	Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p	regulation of nuclear-transcribed mRNA poly(A) tail shortening|endocytosis|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly	protein kinase activity	cytosol|cell cortex|eisosome
YCR021C	HSP30	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0749726852742933	1.37545072712938e-05	27	Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase	negative regulation of ATPase activity|response to stress	molecular_function	integral to membrane|plasma membrane
YKR030W	GMH1	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0731179327338696	2.2362697361143e-05	28	Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting	transport	molecular_function	integral to membrane|integral to Golgi membrane
YCL026C-A	FRM2	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS	0.0730147019868885	2.41594264011581e-05	29	Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin	cellular response to oxidative stress|negative regulation of fatty acid metabolic process	oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor	nucleus|cytoplasm
YLL045C	RPL8B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0724307862965493	2.66984173949953e-05	30	Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR059C	UBC5	hom			0.0722751085099608	2.80939954835296e-05	31	Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication	protein polyubiquitination|response to stress	ubiquitin-protein ligase activity	proteasome complex
YIL159W	BNR1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH	0.0722697438236272	2.78243943925132e-05	32	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1	barbed-end actin filament capping|actin filament bundle assembly|formin-nucleated actin cable assembly	profilin binding	cellular bud neck
YDL057W_p	YDL057W	hom			0.0721504635640409	2.86873158791281e-05	33	Putative protein of unknown function; YDL057W is not an essential gene	biological_process	molecular_function	cellular_component
YDL222C	FMP45	hom	FT	CELL WALL ORG/BIOGENESIS|MITOCHONDRION|PLASMA MEMBRANE	0.0720367909196619	3.00222948349628e-05	34	Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C	fungal-type cell wall organization|ascospore formation	molecular_function	cell cortex|mitochondrion|integral to membrane|plasma membrane
YLR136C	TIS11	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|NUCLEUS	0.0715970563268256	3.30343944367257e-05	35	mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	cellular iron ion homeostasis|nuclear-transcribed mRNA catabolic process	mRNA binding	nucleus|cytoplasm
YCL041C_d	YCL041C	het			0.0702541631814624	4.63295777787361e-05	36	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W	Unknown	Unknown	Unknown
YJR137C	MET5	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS	0.0701268666789661	4.84502680929551e-05	37	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine	fungal-type cell wall organization|sulfate assimilation	sulfite reductase (NADPH) activity	sulfite reductase complex (NADPH)|cytoplasm
YFL014W	HSP12	hom	FT	MEMBRANE ORGANIZATION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|PLASMA MEMBRANE	0.0700133318021429	4.91962688812548e-05	38	Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension	cellular response to oxidative stress|cell adhesion|plasma membrane organization|cellular response to osmotic stress|cellular response to heat	lipid binding	cytosol|endosome|nucleus|plasma membrane|cytoplasm
YBL081W_p	YBL081W	hom			0.0677934182903205	8.79632560071407e-05	39	Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport	biological_process	molecular_function	cellular_component
YPR008W	HAA1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0676872845928886	8.70069330730202e-05	40	Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress	response to acid|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YGR077C	PEX8	hom	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	0.067496151726627	9.11092226135289e-05	41	Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p	protein targeting to peroxisome|peroxisome organization	peroxisome targeting sequence binding	peroxisomal matrix|peroxisomal membrane|extrinsic to intraperoxisomal membrane
YNL322C	KRE1	hom	FT	CELL WALL ORG/BIOGENESIS|PLASMA MEMBRANE	0.067406298018746	9.31002396671982e-05	42	Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall|integral to membrane
YKL021C	MAK11	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|ENDOMEMBRANE SYSTEM|NUCLEUS	0.0664597235452322	0.000116725353259576	43	Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats	ribosomal large subunit assembly|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	membrane
YMR288W	HSH155	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0663020901034429	0.000122308759938132	44	U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155	spliceosomal complex assembly|mRNA splicing, via spliceosome	mRNA binding	U2 snRNP|U2-type prespliceosome
YNL218W	MGS1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0662857479145054	0.000121640893106922	45	Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress	regulation of DNA repair|DNA replication, Okazaki fragment processing|DNA strand renaturation	ubiquitin binding|single-stranded DNA-dependent ATPase activity|enzyme activator activity	nucleus|cytoplasm
YBR274W	CHK1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0656419541630737	0.00014158007606134	46	Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase	protein phosphorylation|replication fork protection|DNA damage checkpoint	protein serine/threonine kinase activity	nucleus
YNR017W	TIM23	het	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0656285982634549	0.000142350438402998	47	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel	protein import into mitochondrial matrix	mitochondrion targeting sequence binding|protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane presequence translocase complex
YER037W	PHM8	hom	FT	RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0652254051614322	0.00015607947962515	48	Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p	cellular response to phosphate starvation	lysophosphatidic acid phosphatase activity	nucleus|cytoplasm
YEL060C	PRB1	hom	FT	PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS	0.065184517478877	0.000157575639451509	49	Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress	vacuolar protein catabolic process|sporulation resulting in formation of a cellular spore|cellular response to starvation	serine-type endopeptidase activity	fungal-type vacuole lumen|fungal-type vacuole
YGR136W	LSB1	hom	FT	NUCLEUS	0.0641773163453492	0.000200296945105068	50	Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YLR179C	YLR179C	hom	FT	NUCLEUS	0.0641356129885009	0.000200898781312777	51	Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YDR169C	STB3	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0641259464388144	0.000201345675268394	52	Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter by glucose	sequence-specific DNA binding	nucleus|cytoplasm
YDR530C	APA2	hom	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.0640383608397669	0.000205437606104542	53	Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication	nucleoside catabolic process	bis(5'-nucleosyl)-tetraphosphatase activity	nucleus|cytoplasm
YDL197C	ASF2	hom	FT	GENE SILENCING|NUCLEUS|CHROMOSOME	0.0638258838128704	0.000215691146868207	54	Anti-silencing protein that causes derepression of silent loci when overexpressed	chromatin silencing at silent mating-type cassette	molecular_function	nuclear chromosome, telomeric region|nucleus
YKL029C	MAE1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0634198292606562	0.000239190353322701	55	Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids	pyruvate metabolic process|cellular amino acid metabolic process	malic enzyme activity	mitochondrion
YDR459C	PFA5	hom	FT	PLASMA MEMBRANE	0.0633550242475801	0.000240149755707473	56	Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain	protein palmitoylation	palmitoyltransferase activity	integral to membrane|plasma membrane
YGR072W	UPF3	hom	FT	NUCLEUS	0.0629301173262072	0.000267810955200505	57	Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|translational frameshifting|protein ubiquitination	molecular_function	nucleolus|nucleus|polysome|cytoplasm
YGL215W	CLG1	hom	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	0.0626244161316991	0.000283899044269349	58	Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2	positive regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YDR034C	LYS14	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0623464024378128	0.000302183848903303	59	Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YOR301W	RAX1	hom	FT	CELL CYCLE|SIGNALING|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0622186201129677	0.00031030927651679	60	Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily	cellular bud site selection	molecular_function	integral to membrane|cellular bud neck
YPL076W	GPI2	het	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM	0.062179494880183	0.000316291652075721	61	Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein	GPI anchor biosynthetic process	phosphatidylinositol N-acetylglucosaminyltransferase activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane|endoplasmic reticulum
YDL225W	SHS1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0619667064318388	0.000331657537397445	62	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress	cytokinesis, actomyosin contractile ring assembly|G1 phase of mitotic cell cycle|barrier septum assembly|exit from mitosis|cell cycle cytokinesis|septin ring assembly|cellular bud neck septin ring organization	GTP binding	cellular bud neck septin ring|mating projection tip
YOR234C	RPL33B	hom	FT	TRANSLATION|RIBOSOME	0.0616598057842612	0.000351455985397944	63	Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YIL166C_p	YIL166C	hom			0.061474190813215	0.000366215367200412	64	Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene	transport	transporter activity	integral to membrane|membrane
YGL233W	SEC15	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0609097767875094	0.000414731780128978	65	Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase	Golgi to plasma membrane transport|exocytosis|vesicle fusion|vesicle docking involved in exocytosis	Rab GTPase binding	incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip|exocyst
YPR170C_d	YPR170C	hom			0.0608727230972522	0.000418118054824076	66	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B	Unknown	Unknown	Unknown
YCL069W	VBA3	hom			0.0608080374148081	0.000424933576171819	67	Permease of basic amino acids in the vacuolar membrane	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YDR522C	SPS2	hom	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|PLASMA MEMBRANE	0.0604409548714251	0.000459526145111406	68	Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component	ascospore wall assembly|ascospore formation	molecular_function	fungal-type cell wall|plasma membrane
YDR502C	SAM2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	0.0602059436386464	0.000483641719047196	69	S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication	methionine metabolic process|S-adenosylmethionine biosynthetic process	methionine adenosyltransferase activity	cellular_component
YMR322C_p	SNO4	hom	FT	PROTEOLYSIS	0.0594715568712595	0.000566819120684113	70	Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation	biological_process	cysteine-type peptidase activity	cellular_component
YER123W	YCK3	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION|ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE	0.0593431712142402	0.000588207659408188	71	Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway	vesicle-mediated transport|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	fungal-type vacuole membrane|plasma membrane|nucleus|fungal-type vacuole
YOR094W	ARF3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH	0.0591794823767708	0.000603458049046082	72	Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity	intracellular protein transport|positive regulation of phosphatidylinositol biosynthetic process|endocytosis|actin filament bundle assembly|actin cortical patch localization|cellular bud site selection	mRNA binding|GTPase activity	cellular bud neck|cellular bud tip
YPR082C	DIB1	het	FT	CELL CYCLE|RNA PROCESSING|CELL DIVISION|NUCLEUS	0.0590439448246239	0.000621198356841901	73	17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein	mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex|U5 snRNP
YBL017C	PEP1	hom	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0589859161018355	0.000628940931750536	74	Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments	vacuolar transport|protein targeting to vacuole	signal sequence binding	integral to membrane|Golgi apparatus
YCR012W	PGK1	het	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0588607805507502	0.000645943728334865	75	3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis	gluconeogenesis|glycolysis	phosphoglycerate kinase activity	mitochondrion|plasma membrane|cytoplasm
YHR130C_d	YHR130C	hom			0.0584316835810188	0.000707546476171793	76	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR356W	ATG33	hom	FT	MITOCHONDRION	0.0584120436865065	0.000723681887069998	77	Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes	mitochondrion degradation	molecular_function	mitochondrion|integral to membrane
YKR035W-A	DID2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM	0.0581656857716349	0.000749795570297795	78	Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors	late endosome to vacuole transport via multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole	molecular_function	late endosome|cytoplasm
YMR182C	RGM1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|CHROMOSOME	0.0577257403795657	0.000820888686973744	79	Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nuclear chromatin
YLR254C	NDL1	hom	FT	CELL CYCLE|CELL DIVISION|NUCLEUS|CYTOSKELETON	0.0575291643851961	0.000855323321838812	80	Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends	nuclear migration along microtubule	microtubule plus-end binding	cytoplasmic microtubule|nucleus|cytoplasm
YOR152C_p	YOR152C	hom			0.0575043525220522	0.000859763588658012	81	Putative protein of unknown function; YOR152C is not an essential gene	biological_process	molecular_function	membrane
YDR528W	HLR1	hom	FT	CELL WALL ORG/BIOGENESIS	0.0573877208945442	0.000880923387455063	82	Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A; <br>HLR1 has a paralog, LRE1, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cytoplasm
YPL211W	NIP7	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|RIBOSOME	0.0570292083960144	0.000949025592420482	83	Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p	ribosomal large subunit assembly|ribosomal large subunit biogenesis|rRNA processing	molecular_function	cytosolic large ribosomal subunit|nucleolus|preribosome, large subunit precursor
YNL255C	GIS2	hom	FT	TRANSLATION|RIBOSOME	0.0568812846293101	0.000978520042705379	84	Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2	positive regulation of translation	mRNA binding|translation regulator activity|single-stranded DNA binding	polysomal ribosome|cytoplasm
YMR137C	PSO2	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0563468501834906	0.00109229536561797	85	Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress	DNA repair|double-strand break repair	damaged DNA binding|5'-3' exonuclease activity	nucleus
YDL176W	YDL176W	hom			0.0562400302457306	0.00112605908105008	86	Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene	biological_process	molecular_function	cellular_component
YHR157W	REC104	hom	FT	CELL CYCLE|NUCLEUS|CHROMOSOME	0.0561602812728413	0.00113481159232168	87	Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YAL038W	CDC19	het	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0560109810284581	0.00118393815809561	88	Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication	pyruvate metabolic process|glycolysis	pyruvate kinase activity	cytosol|plasma membrane
YJR019C	TES1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM|MITOCHONDRION	0.0556677938335876	0.00127790772019508	89	Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids	fatty acid beta-oxidation|fatty acid oxidation	acyl-CoA hydrolase activity	mitochondrion|peroxisome
YDL227C	HO	hom	FT	NUCLEUS	0.0555769781281097	0.00127779969932461	90	Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p	mating type switching|gene conversion at mating-type locus, DNA double-strand break formation	endonuclease activity	nucleus
YKL132C	RMA1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.0555737316502848	0.0012786400982036	91	Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	tetrahydrofolylpolyglutamate synthase activity	mitochondrion
YNL310C	ZIM17	het	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0554301628228746	0.00131631900731358	92	Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix	protein folding|protein stabilization|protein import into mitochondrial matrix|response to unfolded protein|mitochondrion organization	chaperone binding	mitochondrion|mitochondrial matrix
YIL010W	DOT5	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|CHROMOSOME	0.0550303579635602	0.00142670897682372	93	Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth	cellular response to oxidative stress|cell redox homeostasis	thioredoxin peroxidase activity	nucleus
YDR517W	GRH1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0547723212953117	0.001502419673063	94	Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress	protein secretion|ER to Golgi vesicle-mediated transport|Golgi organization	molecular_function	COPII vesicle coat|cis-Golgi network|cytoplasm
YGR108W	CLB1	hom	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.054596517890064	0.0015561028078239	95	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|meiotic G2/MI transition|regulation of cyclin-dependent protein kinase activity|mitotic spindle organization in nucleus|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YOL010W	RCL1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0541776147786145	0.00169121049991807	96	Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RNA-3'-phosphate cyclase activity|endoribonuclease activity|enzyme activator activity	nucleolus|90S preribosome
YLR455W	YLR455W	hom	FT	NUCLEUS	0.054173116980413	0.00169271797134446	97	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YJL037W	IRC18	hom			0.0540274499307723	0.00174221243070324	98	Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YKL153W_d	YKL153W	het			0.0540244919089359	0.00174323114166167	99	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant	Unknown	Unknown	Unknown
YKR032W_d	YKR032W	hom			0.0539666969600902	0.00178293456954687	100	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR243W	GPN3	het	FT	PROTEIN LOCALIZATION	0.0537599768502981	0.00183657228623224	101	Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p	biological_process	signal sequence binding	cellular_component
YGR045C_d	YGR045C	hom			0.0536226181284214	0.00188683341168424	102	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR322W_d	VPS65	hom			0.0534920337889275	0.00200340717892199	103	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth	Unknown	Unknown	Unknown
YKL172W	EBP2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0533405050423759	0.00200335182748441	104	Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering	nuclear division|rRNA processing	molecular_function	nuclear periphery|nucleolus|preribosome, large subunit precursor
YPL065W	VPS28	hom	FF|FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT	0.0525995453892453	0.00230278842779699	105	Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	protein complex binding	endosome|ESCRT I complex
YDR099W	BMH2	hom	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.0525715598265018	0.0023152645399241	106	14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	glycogen metabolic process|ascospore formation|Ras protein signal transduction|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|DNA damage checkpoint|DNA replication initiation|signal transduction involved in filamentous growth|pseudohyphal growth|fungal-type cell wall chitin biosynthetic process|pre-replicative complex assembly	DNA replication origin binding|phosphoserine binding	nucleus|plasma membrane
YKL185W	ASH1	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.052491635325206	0.00235123679328954	107	Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate	Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|core promoter proximal region sequence-specific DNA binding	Rpd3L-Expanded complex|nucleus|cellular bud|Rpd3L complex
YML101C	CUE4	hom	FT	ENDOPLASMIC RETICULUM	0.0523950081543727	0.00239540930860639	108	Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication	biological_process	molecular_function	endoplasmic reticulum|cytoplasm
YPR035W	GLN1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0520721842226196	0.00254854942049833	109	Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	nitrogen compound metabolic process|glutamine biosynthetic process	glutamate-ammonia ligase activity	cytoplasm
YJL185C	ATG36	hom			0.0520624785450874	0.0025532891587	110	Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene	peroxisome degradation	molecular_function	peroxisome
YMR077C	VPS20	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT	0.0520541481848369	0.00256877066558917	111	Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes	intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	protein binding	ESCRT III complex|cytoplasm
YDR284C	DPP1	hom	FT	LIPID METABOLISM|SIGNALING	0.0519429955255492	0.00261230219796847	112	Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism	phospholipid metabolic process|signal transduction	diacylglycerol diphosphate phosphatase activity|phosphatidate phosphatase activity	fungal-type vacuole membrane|integral to membrane
YGL198W	YIP4	hom	FT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0516580301378413	0.00278242465229502	113	Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YKL038W	RGT1	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|NUCLEUS	0.051581316125068	0.00279861465125545	114	Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication	glucose transport|regulation of glucose import|negative regulation of transcription from RNA polymerase II promoter|glucose metabolic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nucleus
YKL166C	TPK3	hom	FT	SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0513520822546641	0.002956925775392	115	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication	protein phosphorylation|mitochondrion organization|Ras protein signal transduction	cAMP-dependent protein kinase activity|protein kinase activity	cAMP-dependent protein kinase complex|nucleus|cytoplasm
YOR050C_d	YOR050C	hom			0.0511416754581053	0.00304138687138108	116	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable	Unknown	Unknown	Unknown
YOR262W	GPN2	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION	0.051042215528799	0.00309890645987607	117	Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion	establishment of mitotic sister chromatid cohesion	molecular_function	cytoplasm
YPL140C	MKK2	hom	FT	SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	0.0509672302397629	0.00314292548824567	118	MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication	signal transduction|peroxisome degradation|protein phosphorylation	MAP kinase kinase activity	intracellular
YKL188C	PXA2	hom	FT	NUCLEOTIDE METABOLISM	0.0509477844440556	0.00315443351634658	119	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder	fatty acid transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|integral to peroxisomal membrane
YDR263C	DIN7	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION	0.0509293950834483	0.00319252732313705	120	Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination	DNA repair	nuclease activity	mitochondrion
YGR186W	TFG1	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0508619593597804	0.00320568487978643	121	TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74	transcription initiation from RNA polymerase II promoter|transcriptional start site selection at RNA polymerase II promoter|dephosphorylation of RNA polymerase II C-terminal domain|promoter clearance from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|regulation of protein serine/threonine phosphatase activity	core RNA polymerase II binding transcription factor activity|protein phosphatase activator activity|core RNA polymerase II recruiting transcription factor activity	transcription factor TFIIF complex
YKR102W	FLO10	hom			0.0507665806415167	0.00326353029446618	122	Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth	filamentous growth of a population of unicellular organisms|flocculation via cell wall protein-carbohydrate interaction|flocculation|invasive growth in response to glucose limitation	mannose binding	fungal-type cell wall
YBR109C	CMD1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0506950220392033	0.00330755158334335	123	Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin	karyogamy involved in conjugation with cellular fusion|phosphatidylinositol biosynthetic process|NLS-bearing substrate import into nucleus|microautophagy|cell budding|vacuole fusion, non-autophagic|receptor-mediated endocytosis|cytoskeleton organization|spindle pole body organization|transcription factor import into nucleus	calcium-dependent protein binding|protein binding|calcium ion binding	incipient cellular bud site|central plaque of spindle pole body|mating projection tip|cellular bud neck|cellular bud tip
YLR361C-A_p	YLR361C-A	hom			0.0506933598839605	0.0033085804991484	124	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL186C	UIP4	hom	FT	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0503793093794978	0.00350829723780597	125	Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope	biological_process	molecular_function	mitochondrial outer membrane|nuclear envelope|endoplasmic reticulum
YER008C	SEC3	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH	0.0503079391100808	0.00357007277703552	126	Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress	exocytosis|Golgi to plasma membrane transport|endoplasmic reticulum inheritance|exocyst localization|exocyst assembly|vesicle fusion|vesicle docking involved in exocytosis	Rho GTPase binding|phosphatidylinositol-4,5-bisphosphate binding	incipient cellular bud site|cellular bud neck|mating projection tip|exocyst|cellular bud tip
YOR272W	YTM1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0502155706149699	0.00361671776692147	127	Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats	chromosome organization|ribosomal large subunit biogenesis	molecular_function	PeBoW complex|nucleolus|nucleus|preribosome, large subunit precursor
YDR492W	IZH1	hom	FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0501912855760165	0.00363305511125711	128	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc	response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process	metal ion binding	integral to membrane|endoplasmic reticulum|membrane
YDR312W	SSF2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0500721043419334	0.00375546666400992	129	Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication	conjugation with cellular fusion|ribosomal large subunit assembly	rRNA binding	nucleolus
YBR157C	ICS2	hom			0.0499114440325685	0.00382621385814196	130	Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization	biological_process	molecular_function	cellular_component
YKR004C	ECM9	het	FT	CELL WALL ORG/BIOGENESIS	0.0497234509901263	0.00396116324388563	131	Non-essential protein of unknown function	fungal-type cell wall organization	molecular_function	cellular_component
YMR107W	SPG4	hom			0.0496809784485269	0.00399224391526193	132	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	biological_process	molecular_function	cellular_component
YKR054C	DYN1	hom	FT	CELL CYCLE|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|CYTOSKELETON	0.0495301684451556	0.0041044004055376	133	Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p	nuclear migration along microtubule|establishment of mitotic spindle orientation|mitotic spindle elongation|mitotic sister chromatid segregation	microtubule motor activity	cytoplasmic dynein complex|cell cortex|cytoplasmic microtubule|spindle pole body|astral microtubule
YGR278W	CWC22	het	FT	RNA PROCESSING|NUCLEUS	0.0494247971394496	0.00418445239358126	134	Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex|U2-type catalytic step 1 spliceosome
YLR420W	URA4	hom	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.0494003955849243	0.00420319131557855	135	Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate	'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine nucleotide biosynthetic process	dihydroorotase activity	nucleus|cytoplasm
YER117W	RPL23B	hom	FT	TRANSLATION|RIBOSOME	0.0493748356123672	0.00425140854201779	136	Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR292W	MAL12	hom	FT	CARBOHYDRATE METABOLISM	0.0493592534855635	0.00426353020284775	137	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose	sucrose catabolic process|maltose catabolic process	sucrose alpha-glucosidase activity|maltose alpha-glucosidase activity	plasma membrane
YOR176W	HEM15	het	FT	COFACTOR METABOLISM|MITOCHONDRION	0.049263715636538	0.00431534556843033	138	Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway	heme biosynthetic process	ferrochelatase activity	mitochondrion|mitochondrial inner membrane
YDL091C	UBX3	hom			0.0492169309801566	0.00434653559326375	139	Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10	biological_process	molecular_function	cytoplasm
YMR004W	MVP1	hom	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|NUCLEUS	0.0491693142489382	0.0043844564428033	140	Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress	protein targeting to vacuole	phosphatidylinositol-3-phosphate binding	nucleus|cytoplasm
YKL190W	CNB1	hom	FF|FT	SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS	0.0490658044458061	0.00446792518506067	141	Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding	calcineurin complex
YLR400W_d	YLR400W	hom			0.048874582872587	0.00462591787657737	142	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER128W	VFA1	hom	FT	VACUOLAR TRANSPORT	0.0486201349285814	0.00484398902670254	143	Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology	vacuolar transport	molecular_function	endosome|cytoplasm
YOL114C_p	YOL114C	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	0.0484873240215182	0.00496146768001752	144	Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene	biological_process	molecular_function	cellular_component
YDL095W	PMT1	hom	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0484367129138205	0.00504608476817524	145	Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen	ER-associated misfolded protein catabolic process|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YOR360C	PDE2	hom	FT	SIGNALING|NUCLEUS	0.0484287162769574	0.00501412375409481	146	High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon	cAMP-mediated signaling	3',5'-cyclic-AMP phosphodiesterase activity	nucleus|cytoplasm
YDL163W_d	YDL163W	het			0.0481380076276441	0.00528285156803149	147	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase	Unknown	Unknown	Unknown
YGR209C	TRX2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS|ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS	0.0481167778114799	0.00530297660430391	148	Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress	vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|sulfate assimilation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic	disulfide oxidoreductase activity	cytosol|fungal-type vacuole
YDR368W	YPR1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0480256447826459	0.00539015572024508	149	NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YDL199C_p	YDL199C	hom			0.0479785957856081	0.00545652290271688	150	Putative transporter, member of the sugar porter family	transport|transmembrane transport	substrate-specific transmembrane transporter activity	integral to membrane|membrane
YKR039W	GAP1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PLASMA MEMBRANE	0.0477724262721089	0.00563921908439356	151	General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth	amino acid transport|gamma-aminobutyric acid transport|ammonia assimilation cycle|polyamine transport	amino acid transmembrane transporter activity|polyamine transmembrane transporter activity|L-proline transmembrane transporter activity	endosome|fungal-type vacuole lumen|integral to membrane|plasma membrane|ER to Golgi transport vesicle|integral to plasma membrane|multivesicular body
YGL109W_d	YGL109W	hom			0.0477265590847664	0.00568542805896519	152	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C	Unknown	Unknown	Unknown
YGR194C	XKS1	hom	FT	CARBOHYDRATE METABOLISM	0.0476460046639433	0.00576740965377976	153	Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains	xylulose catabolic process	xylulokinase activity	cytoplasm
YIL155C	GUT2	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.04743976673938	0.00598217887858701	154	Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner	NADH oxidation|replicative cell aging|glycerol metabolic process	glycerol-3-phosphate dehydrogenase activity	mitochondrion|integral to mitochondrial outer membrane
YPR173C	VPS4	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM	0.0474345874180251	0.00598766397056063	155	AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism	late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport	ATPase activity|protein homodimerization activity|ATP binding	endosome|endoplasmic reticulum|membrane|cytoplasm
YGL255W	ZRT1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0473845766248345	0.00607866344879263	156	High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor	high-affinity zinc ion transport	high affinity zinc uptake transmembrane transporter activity	integral to membrane|integral to plasma membrane
YGR011W_d	YGR011W	hom			0.0472698749770928	0.00616448025437317	157	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR289C	MAL11	hom	FT	CARBOHYDRATE METABOLISM|PLASMA MEMBRANE	0.0469000193141077	0.00661105057184088	158	Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization	trehalose transport|maltose transport|disaccharide catabolic process	trehalose transmembrane transporter activity|alpha-glucoside:hydrogen symporter activity|maltose:hydrogen symporter activity	integral to membrane|plasma membrane
YGL056C	SDS23	hom	FT	CELL DIVISION|NUCLEUS	0.0468429894275766	0.00665293293786299	159	One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication	cytokinetic cell separation	molecular_function	nucleus|cytoplasm
YPR172W_p	YPR172W	hom	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM|NUCLEUS	0.0467020749051037	0.00681059828712686	160	Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YFL024C	EPL1	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0462898198421199	0.00748529948559038	161	Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb	DNA repair|histone acetylation|regulation of transcription from RNA polymerase II promoter	histone acetyltransferase activity	Piccolo NuA4 histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YLR172C	DPH5	hom			0.0462464396538405	0.00739882995049672	162	Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	diphthine synthase activity	cytoplasm
YIR013C	GAT4	hom	FT	NUCLEUS	0.0462384008702477	0.00747127379991303	163	Protein containing GATA family zinc finger motifs	transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YBR104W	YMC2	hom	FT	MITOCHONDRION	0.0460431510195324	0.00763618239718669	164	Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication	mitochondrial transport|transmembrane transport	organic acid transmembrane transporter activity	mitochondrion|integral to membrane
YNL339C	YRF1-6	hom	FT	NUCLEUS	0.0458160805218879	0.00795013041864832	165	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p	telomere maintenance via recombination	DNA helicase activity	nucleus
YJL029C	VPS53	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0456406322992556	0.0081835839561191	166	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting	Golgi to vacuole transport|retrograde transport, endosome to Golgi	molecular_function	Golgi apparatus|GARP complex|cytoplasm
YKR015C_p	YKR015C	hom			0.0455412680781924	0.00836273132269867	167	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNR040W_p	YNR040W	hom	FT	MITOCHONDRION	0.0454810844504422	0.00841983987269799	168	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YNL333W	SNZ2	hom	FT	COFACTOR METABOLISM	0.0454326550120937	0.00847995593864222	169	Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p	pyridoxine metabolic process|thiamine biosynthetic process	protein binding	cellular_component
YDL093W	PMT5	hom	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0453011727414498	0.008672235299614	170	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals	protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YIL152W_p	YIL152W	hom			0.0452675798140911	0.00872198206106683	171	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPR147C_p	YPR147C	hom			0.0452466576885495	0.00875309367664595	172	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cytoplasm
YBR165W	UBS1	hom	FT	PROTEIN LOCALIZATION|NUCLEUS	0.0451751546937601	0.00886016963674989	173	Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity	protein export from nucleus|protein ubiquitination	molecular_function	nucleus
YPL191C_p	YPL191C	hom			0.0451031407024784	0.00896919145131623	174	Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YPL235W	RVB2	het	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0450982751632354	0.00905884232109808	175	ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly	regulation of transcription from RNA polymerase II promoter|rRNA processing|chromatin remodeling|box C/D snoRNP assembly|histone exchange	ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 3'-5' DNA helicase activity	nuclear telomeric heterochromatin|ASTRA complex|R2TP complex|Swr1 complex|nucleus|Ino80 complex
YDR421W	ARO80	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0450716243442473	0.00901727955105315	176	Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids	aromatic amino acid family catabolic process|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|nucleic acid binding transcription factor activity	nucleus
YPL249C	GYP5	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0450137299506972	0.00914769076652656	177	GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress	vesicle-mediated transport|ER to Golgi vesicle-mediated transport	Rab GTPase activator activity	cytosol|incipient cellular bud site|plasma membrane|cellular bud neck|Golgi-associated vesicle|cellular bud tip
YDR430C	CYM1	hom	FT	PROTEOLYSIS|MITOCHONDRION	0.0447998586850549	0.00944158472039074	178	Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology	proteolysis|proteolysis involved in cellular protein catabolic process	metalloendopeptidase activity	mitochondrion|mitochondrial intermembrane space
YMR181C_p	YMR181C	hom			0.0446764073292481	0.00964014079347034	179	Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YJR098C_p	YJR098C	hom	FT	LIPID METABOLISM|MITOCHONDRION	0.044526829001449	0.00988569846079648	180	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YKR013W	PRY2	hom			0.0444720460828368	0.00997701792810171	181	Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication	biological_process	molecular_function	extracellular region|fungal-type vacuole
YGR181W	TIM13	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0444506716116034	0.0100128509381298	182	Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane	protein import into mitochondrial inner membrane	protein transporter activity	mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex|mitochondrial intermembrane space
YDR133C_d	YDR133C	hom			0.044401358815622	0.0102084666181891	183	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C	Unknown	Unknown	Unknown
YIL013C	PDR11	hom	FT	NUCLEOTIDE METABOLISM	0.044167615690771	0.0105560701863685	184	ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth	sterol transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YMR219W	ESC1	hom	FT	GENE SILENCING|NUCLEUS	0.0440829564665258	0.0106475008386963	185	Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p	chromatin silencing at telomere	molecular_function	nuclear periphery
YKL130C	SHE2	hom	FT	RNA LOCALIZATION|NUCLEUS|SITE OF POLARIZED GROWTH	0.0439590649132935	0.0108692441531927	186	RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud	mating type switching|intracellular mRNA localization	mRNA binding	cellular bud tip|cytoplasm
YLR432W	IMD3	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM	0.043845221033041	0.0110766111519694	187	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed	GTP biosynthetic process	IMP dehydrogenase activity	plasma membrane|cytoplasm
YJR058C	APS2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE	0.0438348496893236	0.0110956760678846	188	Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YBR271W	EFM2	hom			0.0437947831952025	0.0111696014909914	189	S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis	peptidyl-lysine methylation	S-adenosylmethionine-dependent methyltransferase activity|protein-lysine N-methyltransferase activity	cytoplasm
YJR091C	JSN1	hom	FT	PROTEIN LOCALIZATION|MITOCHONDRION	0.0431373458326878	0.0124859723304828	190	Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|cellular protein complex localization|establishment of mitochondrion localization	mRNA binding	external side of mitochondrial outer membrane
YDL234C	GYP7	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	0.0431351709659398	0.0124510737008453	191	GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking	regulation of vacuole fusion, non-autophagic|vesicle-mediated transport	Rab GTPase activator activity	cytoplasm
YNR033W	ABZ1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	0.0431331247814759	0.0125077379112378	192	Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress	para-aminobenzoic acid biosynthetic process	4-amino-4-deoxychorismate synthase activity	cytoplasm
YER063W	THO1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION|NUCLEUS	0.0430242438987852	0.0127454438064283	193	Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation	poly(A)+ mRNA export from nucleus|transcription, DNA-dependent|ribonucleoprotein complex assembly	chromatin binding|double-stranded DNA binding|RNA binding	nucleus
YKL168C	KKQ8	hom	FT	PROTEIN PHOSPHORYLATION	0.0429337337688155	0.0129618131494197	194	Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication	biological_process	protein kinase activity	cytoplasm
YNL157W	IGO1	hom	FT	NUCLEUS	0.0428785442698444	0.0129972960755132	195	Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p	mRNA stabilization	molecular_function	nucleus|cytoplasmic mRNA processing body|cytoplasm
YGL257C	MNT2	hom	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0428746366955214	0.0129920480068395	196	Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans	protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	cellular_component
YBL010C_p	YBL010C	hom	FT	NUCLEUS	0.042869809246603	0.0130022648549205	197	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles	biological_process	molecular_function	clathrin-coated vesicle
YMR294W	JNM1	hom	FF|FT	CELL CYCLE|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0428047105980188	0.0131407355145551	198	Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B	nuclear migration|establishment of mitotic spindle orientation	structural constituent of cytoskeleton	dynactin complex|cell cortex|spindle pole body|astral microtubule
YDL047W	SIT4	hom	FT	CELL CYCLE|RNA PROCESSING|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0427698600573159	0.0132154001080515	199	Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization	intracellular protein kinase cascade|replicative cell aging|G1/S transition of mitotic cell cycle|actin cytoskeleton organization|DNA repair|cellular response to oxidative stress|fungal-type cell wall organization|TOR signaling cascade|dephosphorylation|tRNA wobble uridine modification	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YOR073W	SGO1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.0426978908681829	0.0133707760684282	200	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability	positive regulation of maintenance of meiotic sister chromatid cohesion|meiotic sister chromatid segregation|meiotic sister chromatid separation|sister chromatid biorientation|maintenance of meiotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint|mitotic sister chromatid segregation	molecular_function	condensed nuclear chromosome kinetochore|nucleus|spindle pole body|condensed nuclear chromosome, centromeric region
YGL139W	FLC3	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0426741612771135	0.0134917523347291	201	Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER	FAD transport|transmembrane transport	FAD transmembrane transporter activity	mitochondrion|integral to membrane|endoplasmic reticulum
YOL042W	NGL1	hom	FT	MITOCHONDRION	0.0426245362582023	0.0135866174632387	202	Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	endonuclease activity	mitochondrion
YGL262W_p	YGL262W	hom			0.042521999548284	0.0137573229358744	203	Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene	biological_process	molecular_function	cellular_component
YDR264C	AKR1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0423556041577935	0.0142620608876799	204	Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication	protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation	palmitoyltransferase activity	integral to membrane|Golgi apparatus|membrane
YGR274C	TAF1	het	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RNA POL II, HOLOENZYME	0.0423477746488054	0.0141498989993241	205	TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression	RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter	TBP-class protein binding|chromatin binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|histone acetyltransferase activity	transcription factor TFIID complex
YHL024W	RIM4	hom	FT	CELL CYCLE	0.0422484613894818	0.0143780723713546	206	Putative RNA-binding protein required for the expression of early and middle sporulation genes	meiosis|reciprocal meiotic recombination|sporulation resulting in formation of a cellular spore|premeiotic DNA replication	RNA binding	cytoplasm
YDR380W	ARO10	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0421561809314997	0.0145929888215106	207	Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway	L-phenylalanine catabolic process|methionine catabolic process to 3-methylthiopropanol|tryptophan catabolic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway|leucine catabolic process	pyruvate decarboxylase activity|carboxy-lyase activity|phenylpyruvate decarboxylase activity	cytoplasm
YNR034W	SOL1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0421168788455044	0.014685377641838	208	Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	tRNA export from nucleus	molecular_function|6-phosphogluconolactonase activity	nucleus|cytoplasm
YIL056W	VHR1	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.042089184525033	0.014765634253524	209	Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter in response to biotin starvation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YIL004C	BET1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0420199299750186	0.0149154856931867	210	Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|endoplasmic reticulum membrane|ER to Golgi transport vesicle
YIR043C	YIR043C	hom			0.0419553730846705	0.0150704670628062	211	Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family	biological_process	molecular_function	cellular_component
YJL048C	UBX6	hom	FT	PROTEOLYSIS|NUCLEUS	0.0419428439652742	0.015100709390003	212	UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication	sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process	molecular_function	nucleus
YFR024C-A	LSB3	hom	FT	MITOCHONDRION|SITE OF POLARIZED GROWTH	0.0418387094049692	0.0153541397841929	213	Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication	actin cortical patch localization	molecular_function	mitochondrion|cellular bud neck|cytoplasm
YDR096W	GIS1	hom	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|MITOCHONDRION	0.0417307423706012	0.0156208413766922	214	Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|chronological cell aging|regulation of phospholipid biosynthetic process|histone demethylation|positive regulation of transcription from RNA polymerase II promoter|maintenance of stationary phase in response to starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|histone demethylase activity (H3-K36 specific)	mitochondrion|nucleus
YPR126C_d	YPR126C	hom			0.0416632503232978	0.0160570357348752	215	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR106C	YKU80	hom	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0416209256741001	0.0158962829734065	216	Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair	chromatin assembly or disassembly|protein localization to chromosome|chromatin silencing|double-strand break repair via nonhomologous end joining|donor selection|telomere maintenance|double-strand break repair via homologous recombination	damaged DNA binding|RNA binding|DNA binding|telomeric DNA binding	nuclear chromatin|nuclear telomeric heterochromatin|Ku70:Ku80 complex
YPR059C_d	YPR059C	hom			0.041459767478518	0.0163882560062225	217	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W	Unknown	Unknown	Unknown
YDL169C	UGX2	hom			0.0414234217017167	0.016402417866707	218	Protein of unknown function, transcript accumulates in response to any combination of stress conditions	biological_process	molecular_function	cellular_component
YER015W	FAA2	hom	FT	KETONE METABOLISM|LIPID METABOLISM|MITOCHONDRION	0.0414180308184067	0.0164164290303258	219	Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome	long-chain fatty acid metabolic process	long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|medium-chain fatty acid-CoA ligase activity	mitochondrion|peroxisome
YBR285W_p	YBR285W	hom			0.041396597646802	0.0164722388759708	220	Putative protein of unknown function; YBR285W is not an essential gene	biological_process	molecular_function	cellular_component
YOR106W	VAM3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	0.0413404233572609	0.0166193023116092	221	Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region	autophagic vacuole fusion|vesicle fusion with vacuole|piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle docking|vesicle fusion	protein homodimerization activity|SNAP receptor activity	SNARE complex|fungal-type vacuole membrane
YOR215C	AIM41	hom	FT	MITOCHONDRION	0.0412878147760262	0.0167580745614396	222	Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YGL126W	SCS3	hom	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM	0.0412741531960803	0.0169088425862118	223	Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol	phospholipid metabolic process	molecular_function	integral to membrane|endoplasmic reticulum
YGL209W	MIG2	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|MITOCHONDRION	0.0410434604296342	0.0174160529209571	224	Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	mitochondrion|nucleus
YKL128C	PMU1	hom	FT	NUCLEUS	0.0410402569214771	0.0174248273622007	225	Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant	biological_process	molecular_function	nucleus|cytoplasm
YKL085W	MDH1	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0408907906443139	0.0179239353194423	226	Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated	chronological cell aging|replicative cell aging|tricarboxylic acid cycle|aerobic respiration	L-malate dehydrogenase activity|mRNA binding	mitochondrion|mitochondrial matrix
YDL239C	ADY3	hom	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION|NUCLEUS|CYTOSKELETON	0.0408768208532168	0.0179803291884793	227	Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication	mitochondrion inheritance|ascospore wall assembly|sporulation resulting in formation of a cellular spore	molecular_function	spindle pole body|prospore membrane
YMR305C	SCW10	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOPLASMIC RETICULUM	0.0408320394076691	0.0180035112949072	228	Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p	conjugation with cellular fusion	glucosidase activity	fungal-type cell wall|extracellular region|endoplasmic reticulum|cytoplasm
YDR257C	RKM4	hom	FT	NUCLEUS	0.0407945738817701	0.0181094039794964	229	Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein	peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	nucleus
YGL037C	PNC1	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING|NUCLEUS	0.0405910610428411	0.0186941901627072	230	Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress	replicative cell aging|chromatin silencing at rDNA|nicotinate nucleotide salvage|chromatin silencing at telomere	nicotinamidase activity	nucleus|peroxisome|cytoplasm
YDR179C	CSN9	hom	FT	SIGNALING|NUCLEUS	0.0405803410060999	0.0187961422716982	231	Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	molecular_function	signalosome
YHR160C	PEX18	hom	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	0.0402725387934912	0.0196426073500851	232	Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p	protein import into peroxisome matrix	protein binding	cytosol|peroxisome
YGL192W	IME4	hom	FT	CELL CYCLE|NUCLEUS	0.0402725167873466	0.0196975119944371	233	Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids	meiosis|mRNA methylation	mRNA (N6-adenosine)-methyltransferase activity	cellular_component
YJR152W	DAL5	hom	FT	PLASMA MEMBRANE	0.0401037024823673	0.0202366816363875	234	Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression	dipeptide transport|allantoate transport	dipeptide transporter activity|allantoate transmembrane transporter activity	integral to membrane|plasma membrane
YKR034W	DAL80	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0400470471679968	0.0203391667207193	235	Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication	nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YKR041W	YKR041W	hom	FT	NUCLEUS|CYTOSKELETON	0.0400431422870062	0.0203701445733793	236	Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking	biological_process	molecular_function	nucleus|mitotic spindle|cytoplasm
YGL051W	MST27	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE	0.0400398500854797	0.0203617492975533	237	Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles	vesicle organization	molecular_function	integral to membrane|Golgi apparatus|endoplasmic reticulum|plasma membrane
YOR297C	TIM18	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.0399698429315117	0.0205825566341566	238	Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex	cellular response to oxidative stress|protein import into mitochondrial inner membrane|apoptotic process|response to acid|response to osmotic stress|response to arsenic-containing substance	protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YML086C	ALO1	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.039819478813571	0.0210638814622407	239	D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress	cellular response to oxidative stress|dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinono-1,4-lactone oxidase activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YHL003C	LAG1	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0397761639094141	0.021281573590084	240	Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress	replicative cell aging|ceramide biosynthetic process	sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YPR188C	MLC2	hom	FT	CELL CYCLE|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0396916906470376	0.0215780877899307	241	Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring	actomyosin contractile ring contraction	myosin II binding	cellular bud neck contractile ring
YGL095C	VPS45	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0396906829776394	0.0215423647949432	242	Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment	vacuole inheritance|CVT pathway|positive regulation of SNARE complex assembly|Golgi vesicle fusion to target membrane|Golgi to vacuole transport|vacuole organization|vacuolar acidification|protein targeting to vacuole|Golgi to endosome transport	unfolded protein binding|SNARE binding	cytosol|SNARE complex|Golgi membrane|extrinsic to membrane
YPL217C	BMS1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM|NUCLEUS|MITOCHONDRION	0.0396386372838174	0.0216557261656706	243	GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p	ribosome assembly|rRNA processing	U3 snoRNA binding|GTP binding|GTPase activity	mitochondrion|nucleolus|nucleus|90S preribosome|cytoplasm
YMR042W	ARG80	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0395291898090352	0.0223399524408729	244	Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding	nucleus
YCR030C	SYP1	hom	FT	CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH	0.039432610775917	0.0223475775815378	245	Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization	septin cytoskeleton organization|actin cortical patch assembly	molecular_function	mating projection base|mating projection tip|cellular bud neck|cellular bud tip
YLR342W	FKS1	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON	0.0393900648438098	0.0224928189685917	246	Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling	(1->3)-beta-D-glucan biosynthetic process|positive regulation of endocytosis|regulation of cell size	1,3-beta-D-glucan synthase activity	mitochondrion|1,3-beta-D-glucan synthase complex|integral to membrane|plasma membrane|cellular bud neck|cellular bud tip|actin cortical patch
YIL120W	QDR1	hom	FT	PLASMA MEMBRANE	0.0393659745753761	0.0225754203668931	247	Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication	drug transmembrane transport	drug transmembrane transporter activity	integral to membrane|plasma membrane
YLR351C	NIT3	hom	FT	MITOCHONDRION	0.0393072536025613	0.0227778694113038	248	Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member	biological_process	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	mitochondrion|cytoplasm
YLR417W	VPS36	hom	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.0392653941558094	0.0229843071817712	249	Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome	negative regulation of transcription from RNA polymerase II promoter by glucose|protein retention in Golgi apparatus|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	ubiquitin binding	ESCRT II complex
YNL313C	EMW1	het	FT	CELL WALL ORG/BIOGENESIS|NUCLEUS	0.0391843370441541	0.0232272962666163	250	Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress	fungal-type cell wall organization	molecular_function	nucleus|cytoplasm
YGL059W	PKP2	hom	FT	CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|MITOCHONDRION	0.039167921583286	0.0232645564417321	251	Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization|negative regulation of catalytic activity	protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity	mitochondrion
YOR353C	SOG2	het	FT	CELL CYCLE|SIGNALING|CELL DIVISION|SITE OF POLARIZED GROWTH	0.0391507534463993	0.0233251448097545	252	Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis	signal transduction|cytokinetic cell separation|budding cell apical bud growth	molecular_function	incipient cellular bud site|cellular bud|mating projection tip|cytoplasm
YLR133W	CKI1	hom	FT	LIPID METABOLISM	0.0390786011423299	0.0235812780211034	253	Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolamine kinase activity|choline kinase activity	cytoplasm
YER178W	PDA1	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0390762976393578	0.0235894952465989	254	E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose	acetyl-CoA biosynthetic process from pyruvate	pyruvate dehydrogenase (acetyl-transferring) activity	mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YOR267C	HRK1	hom	FT	ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS	0.0390522928083975	0.023675274950854	255	Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress	protein phosphorylation|cellular ion homeostasis	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YDR131C_p	YDR131C	hom	FT	PROTEOLYSIS	0.038876394150216	0.0243971348622653	256	F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YHL042W_p	YHL042W	hom			0.0388205302055918	0.0245174727374361	257	Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	cellular_component
YKR035C_d	OPI8	hom			0.0387733984675339	0.0247993368153456	258	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A	Unknown	Unknown	Unknown
YIR015W	RPR2	het	FT	RNA PROCESSING|NUCLEUS	0.0387385296249331	0.0248216059374789	259	Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress	tRNA processing|intronic box C/D snoRNA processing	ribonuclease P activity	nucleolar ribonuclease P complex
YLR285W	NNT1	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING	0.038699386875076	0.02514142085855	260	S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination	chromatin silencing at rDNA|nicotinamide metabolic process	S-adenosylmethionine-dependent methyltransferase activity|nicotinamide N-methyltransferase activity	cytoplasm
YIR025W	MND2	hom	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CHROMOSOME SEGREGATION|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0386614237554438	0.0251105590244013	261	Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|reciprocal meiotic recombination|regulation of mitotic metaphase/anaphase transition|protein ubiquitination|mitotic sister chromatid segregation	molecular_function	nucleus|anaphase-promoting complex
YDL235C	YPD1	het	FT	SIGNALING|NUCLEUS	0.0386598751829447	0.025116391968122	262	Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus	osmosensory signaling pathway via two-component system	protein histidine kinase binding|transferase activity, transferring phosphorus-containing groups	nucleus|cytoplasm
YFR028C	CDC14	het	FT	CELL CYCLE|NUCLEUS|CYTOSKELETON	0.038463654457373	0.0261321752363258	263	Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis	regulation of exit from mitosis|mitotic cell cycle|protein dephosphorylation	phosphoprotein phosphatase activity	nucleolus|RENT complex|nucleus|spindle pole body
YCL012C	YCL012C	hom			0.0383071264923866	0.0266793260769293	264	Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene	biological_process	molecular_function	cellular_component
YGL241W	KAP114	hom	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS	0.038300531934268	0.0265020109534958	265	Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress	protein import into nucleus|transcription factor import into nucleus	protein transporter activity	integral to membrane|nucleus|cytoplasm
YNL314W	DAL82	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0381826985326854	0.026970520350946	266	Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain	allantoin catabolic process|nitrogen catabolite activation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YML109W	ZDS2	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|GENE SILENCING|NUCLEUS|SITE OF POLARIZED GROWTH	0.0379772766164185	0.0278043843809181	267	Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication	positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|establishment of cell polarity|regulation of protein localization|chromatin silencing at rDNA|cell aging	molecular_function	nucleus|cellular bud neck|cellular bud tip|cytoplasm
YLR105C	SEN2	het	FT	RNA PROCESSING|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	0.0379723205170052	0.0279882503795911	268	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease	tRNA-type intron splice site recognition and cleavage	tRNA-intron endonuclease activity	mitochondrial outer membrane|mitochondrion|tRNA-intron endonuclease complex
YLR219W	MSC3	hom	FT	CELL CYCLE|PLASMA MEMBRANE	0.0379530094399468	0.0279043438565787	269	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress	reciprocal meiotic recombination	molecular_function	cellular_component
YIL070C	MAM33	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0378244997955432	0.0284388685743781	270	Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R	aerobic respiration	molecular_function	mitochondrion|mitochondrial matrix
YKL201C	MNN4	hom	FT	CARBOHYDRATE METABOLISM	0.0376376763525519	0.0292316588669279	271	Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication	protein O-linked glycosylation|protein N-linked glycosylation|response to stress	molecular_function	membrane
YLR067C	PET309	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0375692581190935	0.0295267117171951	272	Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)	positive regulation of mitochondrial translational initiation|RNA metabolic process|mitochondrial respiratory chain complex IV biogenesis|aerobic respiration	translation regulator activity	extrinsic to mitochondrial inner membrane|mitochondrion|integral to membrane|mitochondrial inner membrane
YDR171W	HSP42	hom	FT	CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0374840038584021	0.03014349384563	273	Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	cytoskeleton organization	unfolded protein binding	cytoskeleton|chaperonin-containing T-complex|cytoplasm
YJR102C	VPS25	hom	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.0374178863959568	0.030262537520704	274	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome	negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	structural molecule activity	ESCRT II complex
YDR222W_p	YDR222W	hom	FT	RESPONSE TO OXIDATIVE STRESS	0.0374132784074058	0.0302089591744062	275	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YGR099W	TEL2	het	FT	PROTEIN LOCALIZATION|NUCLEUS|CHROMOSOME	0.0373742493128979	0.0304560185189383	276	Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1	protein localization to chromosome|telomere maintenance via telomerase|telomere maintenance	telomeric DNA binding	ASTRA complex|nuclear telomere cap complex
YDL074C	BRE1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME	0.037169727425806	0.0313013056275363	277	E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control	mitotic cell cycle G1/S transition DNA damage checkpoint|intra-S DNA damage checkpoint|meiotic DNA double-strand break formation|histone monoubiquitination|double-strand break repair via homologous recombination|transcription from RNA polymerase II promoter|chromatin silencing at telomere	ubiquitin-protein ligase activity	nuclear chromatin
YDR132C	YDR132C	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|NUCLEUS|PLASMA MEMBRANE	0.0371565983574786	0.0313611407461368	278	Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YEL059W_d	HHY1	hom			0.0371411053077896	0.0314318757419729	279	Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking	Unknown	Unknown	Unknown
YLR330W	CHS5	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH	0.0370444851697471	0.0318760981704312	280	Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane	ascospore wall assembly|conjugation with cellular fusion|cell wall chitin catabolic process|Golgi to plasma membrane transport|cellular bud site selection|regulation of transcription, DNA-dependent	molecular_function	mating projection tip|cytoplasm|exomer complex
YBR287W_p	YBR287W	hom	FT	ENDOPLASMIC RETICULUM	0.0370107154003581	0.0320326222883295	281	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YCL008C	STP22	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|PLASMA MEMBRANE	0.03694762788698	0.0323267998354097	282	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding	endosome|ESCRT I complex|internal side of plasma membrane
YOR024W_d	YOR024W	hom			0.0368655323729949	0.032713073788082	283	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL056W	HAT2	hom	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0368605965412165	0.0327364231308324	284	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing	histone acetylation|chromatin assembly or disassembly|chromatin silencing at telomere	histone acetyltransferase activity|histone binding	histone acetyltransferase complex|nucleus|cytoplasm
YMR121C	RPL15B	hom	FT	TRANSLATION|RIBOSOME	0.0366298848647468	0.0338438539213787	285	Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YPR183W	DPM1	het	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.036626977733775	0.0338846002005432	286	Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation	GPI anchor biosynthetic process|protein O-linked glycosylation|protein N-linked glycosylation	dolichyl-phosphate beta-D-mannosyltransferase activity	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YDL150W	RPC53	het	FF|FT	NUCLEUS	0.0365214647375788	0.0343752394138486	287	RNA polymerase III subunit C53	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YLR210W	CLB4	hom	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS|CYTOSKELETON	0.0363578984310356	0.0352176619215974	288	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation	G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|spindle pole body|cytoplasm
YKL136W_d	YKL136W	hom			0.0363363245695527	0.0352991186294289	289	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C	Unknown	Unknown	Unknown
YDR097C	MSH6	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0362820319701589	0.0355740316526031	290	Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p	mismatch repair|meiotic mismatch repair	guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity|single base insertion or deletion binding|ATP binding	MutSalpha complex|nucleus
YER114C	BOI2	hom	FT	SIGNALING|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0360954366629223	0.0365328274026956	291	Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication	cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction	phospholipid binding	site of polarized growth|cellular bud|cellular bud neck
YGR245C	SDA1	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CYTOSKELETON ORGANIZATION|NUCLEUS	0.0359760798261291	0.0371575985360109	292	Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis	ribosomal large subunit biogenesis|ribosomal large subunit export from nucleus|traversing start control point of mitotic cell cycle|actin cytoskeleton organization	molecular_function	nucleus
YKR026C	GCN3	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.035967190861004	0.0372044892858229	293	Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression	regulation of translational initiation	enzyme regulator activity|guanyl-nucleotide exchange factor activity|translation initiation factor activity	eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YNL117W	MLS1	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	0.0359616058986441	0.0372339766286307	294	Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic	glyoxylate cycle	malate synthase activity	peroxisomal matrix|cytoplasm
YMR060C	SAM37	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0359000754261123	0.0375601622229141	295	Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability	mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to membrane
YFL046W_p	FMP32	hom	FT	MITOCHONDRION	0.0358952652940405	0.0375857638299842	296	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YER001W	MNN1	hom	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0358550166219639	0.0378005669570434	297	Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family	N-glycan processing|protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	Golgi apparatus
YGL149W_d	YGL149W	hom			0.0358153823533947	0.0380131102294012	298	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.	Unknown	Unknown	Unknown
YDR379W	RGA2	hom	FT	SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.035810326611875	0.0380402951380857	299	GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p	budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|actin filament organization|pseudohyphal growth|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth	Rho GTPase activator activity	cellular bud neck split septin rings
YIL165C_p	YIL165C	hom			0.0357878312432849	0.0381614540027211	300	Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene	mitochondrion degradation	molecular_function	cellular_component
YDR361C	BCP1	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0357470055457975	0.0384688822051401	301	Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport	protein export from nucleus|ribosomal large subunit export from nucleus	molecular_function	nucleus|cytoplasm
YBR089C-A	NHP6B	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0356837355906589	0.0387263866391536	302	High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication	RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling|transcription from RNA polymerase II promoter	nucleosome binding|DNA binding, bending|sequence-specific DNA binding	nucleus
YPR159C-A_p	YPR159C-A	hom			0.0356363666910197	0.0389858023569171	303	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YER120W	SCS2	hom	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH	0.0355767421002191	0.0393144323840104	304	Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication	endoplasmic reticulum inheritance|regulation of intracellular lipid transport|negative regulation of transcription factor import into nucleus|phospholipid biosynthetic process|chromatin silencing at telomere	phosphatidylinositol binding|FFAT motif binding	nuclear membrane|integral to endoplasmic reticulum membrane|nuclear envelope|endoplasmic reticulum|cellular bud tip
YOR141C	ARP8	hom	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME|CYTOSKELETON	0.0355489424289431	0.0394684563191052	305	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity	mitotic recombination|response to DNA damage stimulus|chromatin remodeling	mRNA binding|ATP-dependent 3'-5' DNA helicase activity	nucleus|Ino80 complex
YNL071W	LAT1	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0355260957666581	0.0395954211558896	306	Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA	acetyl-CoA biosynthetic process from pyruvate	dihydrolipoyllysine-residue acetyltransferase activity	mitochondrion|mitochondrial pyruvate dehydrogenase complex
YLR454W_p	FMP27	hom	FT	MITOCHONDRION	0.0354224815740766	0.0401755898822928	307	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YBR221W-A_p	YBR221W-A	hom			0.0353106003871299	0.040840174889757	308	Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YOR273C	TPO4	hom	FF|FT	PLASMA MEMBRANE	0.0352890697659665	0.0409332045468611	309	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane	spermidine transport|spermine transport	spermidine transmembrane transporter activity|spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YGR122C-A_d	YGR122C-A	hom			0.0352538632180256	0.0411351406216443	310	Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W	Unknown	Unknown	Unknown
YNR050C	LYS9	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0352338196564989	0.0412504819266186	311	Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112	lysine biosynthetic process via aminoadipic acid	saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity	cytoplasm
YPR015C_p	YPR015C	hom			0.0352320064740798	0.0412609294342128	312	Putative protein of unknown function; overexpression causes a cell cycle delay or arrest	biological_process	sequence-specific DNA binding	cellular_component
YMR074C	YMR074C	hom	FT	NUCLEUS	0.0351773740408112	0.0415767723138588	313	Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress	apoptotic process	molecular_function	nucleus|cytoplasm
YDR079C-A	TFB5	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME	0.0351658614406238	0.0416435897294109	314	Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleus
YDR295C	HDA2	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0350830673347804	0.0421267960752865	315	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance	negative regulation of transcription from RNA polymerase II promoter|gene silencing by RNA|histone deacetylation|gene silencing involved in chronological cell aging	histone deacetylase activity|chromatin binding|DNA binding	nucleus|HDA1 complex
YDR440W	DOT1	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS	0.0350776243911744	0.0424975592857838	316	Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response	meiotic recombination checkpoint|postreplication repair|recombinational repair|global genome nucleotide-excision repair|nucleotide-excision repair|DNA damage checkpoint|chromatin silencing at telomere|histone H3-K79 methylation	nucleosomal histone binding|histone methyltransferase activity (H3-K79 specific)	nucleus
YER118C	SHO1	hom	FT	SIGNALING|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0350395883059729	0.0423824435513164	317	Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p	signal transduction involved in filamentous growth|establishment of cell polarity|osmosensory signaling pathway|cellular response to heat|cytokinesis	osmosensor activity|MAP-kinase scaffold activity	integral to membrane|plasma membrane|plasma membrane part|cellular bud|cellular bud neck|mating projection tip
YPL133C	RDS2	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0349685907835837	0.0428027133149702	318	Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|cellular response to xenobiotic stimulus|positive regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YDR246W-A_p	YDR246W-A	hom			0.0349484105655097	0.0429228109217653	319	Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YGL019W	CKB1	hom	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS	0.034941338051796	0.0430893480893517	320	Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases	regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein kinase regulator activity|protein serine/threonine kinase inhibitor activity	protein kinase CK2 complex|UTP-C complex
YLL050C	COF1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	0.0348955454866648	0.0432699607352291	321	Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes	actin filament depolymerization|actin filament severing	actin filament binding	plasma membrane|actin cortical patch
YJL211C_d	YJL211C	hom			0.0348111394788404	0.0439361947774278	322	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2	Unknown	Unknown	Unknown
YNR073C_p	YNR073C	hom			0.0348095482911272	0.0438513010970008	323	Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p	biological_process	mannitol dehydrogenase activity	cellular_component
YKR094C	RPL40B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION|NUCLEUS|MITOCHONDRION|RIBOSOME	0.0347708670041771	0.0441496320846281	324	Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication	cytoplasmic translation|protein ubiquitination|ribosome biogenesis	structural constituent of ribosome|protein tag	mitochondrion|cytosolic large ribosomal subunit
YJL051W	IRC8	hom			0.0347619999240231	0.0441720742422078	325	Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc	mitotic recombination	molecular_function	integral to membrane|cellular bud
YDL243C	AAD4	hom	FT	OXIDATION-REDUCTION PROCESS	0.0347403776875153	0.0443041525091403	326	Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YDR414C	ERD1	hom	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0346951323619187	0.0444545025269963	327	Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)	protein retention in ER lumen|protein glycosylation	molecular_function	integral to membrane|membrane
YOL091W	SPO21	hom	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON	0.0346509586327819	0.0448219713190944	328	Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation	ascospore wall assembly|meiosis	structural molecule activity	spindle pole body
YOR216C	RUD3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|GOLGI APPARATUS	0.0346476920114363	0.0447464633746027	329	Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1	ER to Golgi vesicle-mediated transport	molecular_function	Golgi apparatus
YJL110C	GZF3	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0346407897809327	0.0447890760017515	330	GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication	maintenance of protein location in nucleus|nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YPL130W	SPO19	hom	FT	CELL CYCLE|MEMBRANE ORGANIZATION	0.0345549734637934	0.0453217473840543	331	Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation	meiosis|spore membrane bending pathway	molecular_function	fungal-type cell wall|prospore membrane
YGR258C	RAD2	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|NUCLEUS	0.0345403598568188	0.0454129854192214	332	Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein	nucleotide-excision repair, DNA incision, 3'-to lesion|transcription from RNA polymerase II promoter	single-stranded DNA specific endodeoxyribonuclease activity	nucleotide-excision repair factor 3 complex
YKL221W	MCH2	hom			0.0345384155521281	0.0454251360719084	333	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|membrane
YCL034W	LSB5	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0344908016813378	0.0458205547544841	334	Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat	endocytosis|actin filament organization|actin cortical patch localization|actin cytoskeleton organization	molecular_function	cell cortex|cytoplasm|actin cortical patch
YKR061W	KTR2	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0344424643498014	0.0460281810446804	335	Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication	cell wall mannoprotein biosynthetic process|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YLR349W_d	YLR349W	hom			0.0343470943592046	0.0466342375359403	336	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C	Unknown	Unknown	Unknown
YNL304W	YPT11	hom	FT	SIGNALING|MITOCHONDRION ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH	0.0343435277516924	0.0466570321945781	337	Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells	mitochondrion inheritance|endoplasmic reticulum inheritance|Golgi inheritance|Golgi localization	GTPase activity	incipient cellular bud site|endoplasmic reticulum|cellular bud neck|cellular bud tip
YCL075W	YCL075W	hom	FT	NUCLEUS	0.0342059601293467	0.0475434248526431	338	Pseudogene: encodes fragment of Ty Pol protein	transposition, RNA-mediated	ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity	retrotransposon nucleocapsid
YPR022C_p	YPR022C	hom	FT	NUCLEUS	0.0341764544095294	0.0477353716316067	339	Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	sequence-specific DNA binding	nucleus|cytoplasm
YPL067C_p	YPL067C	hom			0.0341668886551738	0.0477977403661166	340	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene	biological_process	molecular_function	cytoplasm
YDR028C	REG1	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.0341339747242378	0.0480128625166934	341	Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p	cellular response to glucose starvation|vacuolar protein catabolic process|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of carbohydrate metabolic process	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex|cytoplasm
YLR334C_d	YLR334C	hom			0.0341117047329964	0.0481588777242803	342	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here	Unknown	Unknown	Unknown
YKL002W	DID4	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT	0.0340650199260072	0.0485667993979641	343	Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis	protein retention in Golgi apparatus|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	molecular_function	ESCRT III complex|cytoplasm
YOR376W_d	YOR376W	hom			0.0339878854557355	0.0489775266542724	344	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.	Unknown	Unknown	Unknown
YLR212C	TUB4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	0.0339554722739662	0.0494650578455214	345	Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress	microtubule nucleation|mitotic spindle organization in nucleus	structural constituent of cytoskeleton	outer plaque of spindle pole body|gamma-tubulin small complex, spindle pole body|inner plaque of spindle pole body
YLR405W	DUS4	hom	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	0.0338657609344751	0.0499328608819012	346	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p	tRNA modification	tRNA dihydrouridine synthase activity	cellular_component
YBR229C	ROT2	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0338163676104278	0.0501308030012927	347	Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations	fungal-type cell wall biogenesis	alpha-glucosidase activity	glucosidase II complex|mitochondrion|endoplasmic reticulum|endoplasmic reticulum lumen
YOR055W_d	YOR055W	hom			0.0337805010457357	0.0503748225124832	348	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL089W	MIF2	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE	0.0336891228934915	0.0510010171387733	349	Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3	chromosome segregation|mitotic spindle organization in nucleus	centromeric DNA binding	condensed nuclear chromosome, centromeric region|condensed nuclear chromosome inner kinetochore
YHR032W	ERC1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	0.0336361274575892	0.0513671593347923	350	Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine	S-adenosylmethionine biosynthetic process|transmembrane transport	antiporter activity	integral to membrane
YDL068W_d	YDL068W	hom			0.033542066199001	0.0520224386796062	351	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL134C_d	YOL134C	het			0.0335317385484929	0.0520948103871638	352	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit	Unknown	Unknown	Unknown
YDR154C_d	YDR154C	hom			0.033495785794065	0.0523825604352067	353	Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein	Unknown	Unknown	Unknown
YDR185C	UPS3	hom	FT	MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0334929117688084	0.0523676451473938	354	Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations	mitochondrion morphogenesis	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YJL043W_p	YJL043W	hom	FT	MITOCHONDRION	0.0334142019066766	0.052924402575892	355	Putative protein of unknown function; YJL043W is a non-essential gene	biological_process	molecular_function	mitochondrion|cytoplasm
YLR169W_d	YLR169W	hom			0.0333969910898057	0.05304680047971	356	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR259C	YAP6	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0333642432355618	0.0533870242588694	357	Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding transcription factor recruiting transcription factor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YOL052C	SPE2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.0333561522308379	0.0533381798322744	358	S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically	spermidine biosynthetic process|spermine biosynthetic process|pantothenate biosynthetic process	adenosylmethionine decarboxylase activity	nucleus|cytoplasm
YLL024C	SSA2	hom	FT	PROTEIN LOCALIZATION|MITOCHONDRION	0.0333289151704325	0.053568891539465	359	ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity|ATP binding	cytosol|fungal-type vacuole membrane|mitochondrion|fungal-type cell wall|plasma membrane|polysome|chaperonin-containing T-complex|cytoplasm
YGL041C-B_p	YGL041C-B	hom			0.0332368561057382	0.0541970026392179	360	Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YOR322C	LDB19	hom	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|GOLGI APPARATUS|PLASMA MEMBRANE	0.0332019905927172	0.054450169686808	361	Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye	ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	cytosol|Golgi apparatus|plasma membrane|clathrin-coated vesicle|cytoplasm
YKL205W	LOS1	hom	FT	RNA PROCESSING|RNA LOCALIZATION|NUCLEUS|MITOCHONDRION	0.033186098583251	0.0546741326382816	362	Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus	tRNA binding|Ran GTPase binding	mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YDL214C	PRR2	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0331846549005229	0.0548293597316405	363	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance	negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation	protein kinase activity|receptor signaling protein serine/threonine kinase activity	nucleus
YNL035C	YNL035C	hom	FT	NUCLEUS	0.0331059165041975	0.0551528942599177	364	Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YJR072C	NPA3	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION	0.0330897800478816	0.0552716608037863	365	Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress	cellular protein complex localization|nucleocytoplasmic transport|mitotic sister chromatid cohesion	ATPase activity|GTPase activity	cytoplasm
YKL152C	GPM1	het	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0330892993463449	0.0552752020990277	366	Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis	gluconeogenesis|glycolysis	phosphoglycerate mutase activity	cytosol|mitochondrion
YGL150C	INO80	het	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0330482492225829	0.055578313607593	367	ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription	nucleosome positioning|histone exchange|transcription from RNA polymerase II promoter|DNA repair|nucleosome mobilization|chromatin remodeling|chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	ATPase activity|ATP-dependent 3'-5' DNA helicase activity	Ino80 complex
YPL223C	GRE1	hom			0.0330321704611342	0.0556974148573785	368	Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway	biological_process	molecular_function	cytoplasm
YPR159W	KRE6	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0330260013314205	0.0558162434522177	369	Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p	fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process	glucosidase activity	integral to endoplasmic reticulum membrane|integral to membrane|site of polarized growth|transport vesicle|plasma membrane
YNL013C_d	YNL013C	hom			0.0329500388096344	0.0563458628923545	370	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W	Unknown	Unknown	Unknown
YOL007C	CSI2	hom	FT	SITE OF POLARIZED GROWTH	0.0329369305812412	0.0565545591309475	371	Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene	biological_process	molecular_function	fungal-type vacuole|cellular bud neck
YHR150W	PEX28	hom	FT	PEROXISOME ORGANIZATION	0.032934294701331	0.0564638043957383	372	Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p	peroxisome organization	molecular_function	integral to membrane|peroxisomal membrane
YCR005C	CIT2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0329318614362849	0.0565926103653723	373	Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication	glyoxylate cycle|glutamate biosynthetic process|citrate metabolic process	citrate (Si)-synthase activity	mitochondrion|peroxisome
YLR104W_p	LCL2	hom	FT	PROTEOLYSIS	0.0329255572835385	0.0564925254196841	374	Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)	ER-associated protein catabolic process	molecular_function	cellular_component
YJR024C	MDE1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0329243838729513	0.056501328869192	375	5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant	L-methionine salvage from methylthioadenosine	methylthioribulose 1-phosphate dehydratase activity	cytoplasm
YDR102C_d	YDR102C	hom			0.032903426626874	0.0566587518071123	376	Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index	Unknown	Unknown	Unknown
YNL168C_p	FMP41	hom	FT	MITOCHONDRION	0.0328898497115316	0.0567609311002817	377	Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGR023W	MTL1	hom	FT	CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS|PLASMA MEMBRANE	0.0327843967659304	0.0578584177724363	378	Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p	cellular response to glucose starvation|fungal-type cell wall organization|cellular response to oxidative stress	molecular_function	integral to plasma membrane
YDR117C	TMA64	hom	FT	TRANSLATION	0.0327674534715585	0.0576890170562696	379	Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity	biological_process	RNA binding	ribosome
YLR424W	SPP382	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS|MITOCHONDRION	0.0326670846736252	0.0584594551725368	380	Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation	spliceosomal complex disassembly|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step	RNA binding|ATP-dependent RNA helicase activity	mitochondrion|U2-type post-mRNA release spliceosomal complex|nucleus|spliceosomal complex|cytoplasm
YOR054C	VHS3	hom	FT	CELL CYCLE|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM	0.0326122764562063	0.0588837605886871	381	Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis	coenzyme A biosynthetic process|cellular monovalent inorganic cation homeostasis	phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity	phosphopantothenoylcysteine decarboxylase complex
YJL194W	CDC6	het	FT	CELL CYCLE|CELL DIVISION|GENE SILENCING|NUCLEUS|PLASMA MEMBRANE	0.0325870307061886	0.0590800620630509	382	Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of DNA-dependent DNA replication initiation|regulation of chromatin silencing at telomere|pre-replicative complex assembly|G1/S transition of mitotic cell cycle	DNA replication origin binding|protein binding|chromatin binding|ATPase activity|GTP binding|GTPase activity|ATP binding	DNA replication preinitiation complex|pre-replicative complex
YGL108C	YGL108C	hom			0.0325777411037377	0.059303992485212	383	Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cellular_component
YMR158W-B_d	YMR158W-B	hom			0.0325482129234907	0.0593829536051468	384	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C	Unknown	Unknown	Unknown
YPR190C	RPC82	het	FT	NUCLEUS	0.0325432732028826	0.0594595443537194	385	RNA polymerase III subunit C82	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YDR116C	MRPL1	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0325074303514046	0.0597025624946423	386	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOR052C	YOR052C	hom	FT	NUCLEUS	0.0324594465673595	0.06008043150222	387	Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YOR136W	IDH2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0324516341487381	0.0601421409995603	388	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated	glutamate biosynthetic process|isocitrate metabolic process|tricarboxylic acid cycle	isocitrate dehydrogenase (NAD+) activity	mitochondrial isocitrate dehydrogenase complex (NAD+)|mitochondrion|mitochondrial matrix
YMR005W	TAF4	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0324161725077182	0.0604229096036751	389	TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate	RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter	chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|RNA polymerase II activating transcription factor binding	transcription factor TFIID complex
YKL144C	RPC25	het	FT	NUCLEUS	0.0324151696223246	0.060430865742311	390	RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p	transcription initiation from RNA polymerase III promoter|tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YNL225C	CNM67	hom	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	0.0323068046933673	0.0613343402308871	391	Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication	microtubule nucleation|mitotic spindle organization	structural constituent of cytoskeleton	outer plaque of spindle pole body|spindle pole body
YNL267W	PIK1	het	FF|FT	LIPID METABOLISM|SIGNALING|NUCLEUS|GOLGI APPARATUS	0.0322852113193712	0.0618966364800659	392	Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton	phosphatidylinositol phosphorylation	1-phosphatidylinositol 4-kinase activity	trans-Golgi network|nucleus
YER027C	GAL83	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION|ENDOMEMBRANE SYSTEM|NUCLEUS	0.03227121011756	0.0615819699275025	393	One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain	signal transduction|cell adhesion|protein phosphorylation|invasive growth in response to glucose limitation|regulation of protein complex assembly	AMP-activated protein kinase activity	AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|cytoplasm
YBR059C	AKL1	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH	0.0322171501742658	0.0620188946654001	394	Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization	regulation of endocytosis|protein phosphorylation|actin cytoskeleton organization	protein kinase activity	cellular bud neck|cytoplasm
YLR456W_p	YLR456W	hom	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM|NUCLEUS	0.0321583215112294	0.0627715623499716	395	Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YIL127C_p	RRT14	hom	FT	NUCLEUS	0.032111143039969	0.0631583971726827	396	Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	nucleolus
YCL038C	ATG22	hom	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	0.032090581422122	0.063051887440475	397	Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation	amino acid export from vacuole	molecular_function	integral to fungal-type vacuolar membrane|integral to membrane
YHR046C	INM1	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|NUCLEUS	0.0320640326808595	0.0632703592615316	398	Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate	inositol phosphate dephosphorylation	inositol monophosphate 1-phosphatase activity	nucleus|cytoplasm
YLR278C_p	YLR278C	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0320572398350408	0.0633263585131402	399	Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene	biological_process	sequence-specific DNA binding	nucleus
YDR289C	RTT103	hom	FT	RNA PROCESSING|NUCLEUS|CHROMOSOME	0.0320313921504218	0.0635398175275169	400	Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition	negative regulation of transposition, RNA-mediated|mRNA 3'-end processing	RNA polymerase II core binding	nuclear chromatin|site of double-strand break
YLR170C	APS1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0320100819133469	0.0637162513141806	401	Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YOR222W	ODC2	hom	FT	MITOCHONDRION	0.0319913506465173	0.0641892701849761	402	Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism	mitochondrial transport	dicarboxylic acid transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YER013W	PRP22	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0319251155791483	0.0644635472996311	403	DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes	spliceosomal complex disassembly|generation of catalytic spliceosome for second transesterification step	second spliceosomal transesterification activity|ATP-dependent RNA helicase activity	U2-type post-spliceosomal complex|U2-type catalytic step 2 spliceosome
YHR198C	AIM18	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0319123838334355	0.0645303083803915	404	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YJL176C	SWI3	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|RSC COMPLEX	0.0318475395583797	0.0650753379664105	405	Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	histone binding|DNA binding	SWI/SNF complex|nucleus
YER099C	PRS2	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM	0.0318235726042263	0.0655994022942004	406	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YLR395C	COX8	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0317954376689026	0.0655160101708614	407	Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YLR265C	NEJ1	hom	FT	RESPONSE TO DNA DAMAGE|ENDOMEMBRANE SYSTEM|NUCLEUS	0.0317605008489505	0.0658128772248403	408	Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p	double-strand break repair via nonhomologous end joining|double-strand break repair via single-strand annealing	DNA end binding	DNA ligase IV complex|nucleus
YOR203W_d	YOR203W	het			0.0316408617771509	0.0668378874904767	409	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation	Unknown	Unknown	Unknown
YBR226C_d	YBR226C	hom			0.0316083073937973	0.0671190606069147	410	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W	Unknown	Unknown	Unknown
YOR056C	NOB1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|ENDOPLASMIC RETICULUM	0.031589510846718	0.0672818496000663	411	Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress	proteasome assembly|ribosomal small subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA	endoribonuclease activity|SSU rRNA binding	preribosome, small subunit precursor|nucleus|cytoplasm
YNL076W	MKS1	hom	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|NUCLEUS	0.0315440364658513	0.0676770277852266	412	Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling	regulation of nitrogen utilization|negative regulation of transcription from RNA polymerase II promoter|Unknown|mitochondria-nucleus signaling pathway	molecular_function	cytoplasm
YGL199C_d	YGL199C	hom			0.0313929217652353	0.0690039645757699	413	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W	Unknown	Unknown	Unknown
YBL021C	HAP3	hom	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.0313925053749685	0.0690076501992973	414	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex
YPL046C	ELC1	hom	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0313023824154768	0.0698925958514988	415	Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair	global genome nucleotide-excision repair|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	elongin complex|Cul3-RING ubiquitin ligase complex
YLR122C_d	YLR122C	hom			0.0312595939538952	0.0701923858822481	416	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C	Unknown	Unknown	Unknown
YKR002W	PAP1	het	FT	RNA PROCESSING|NUCLEUS	0.0311559666226429	0.0711276214900012	417	Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping	mRNA polyadenylation|snoRNA polyadenylation	polynucleotide adenylyltransferase activity	nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex
YDR252W	BTT1	hom	FT	PROTEIN LOCALIZATION|NUCLEUS	0.0311521299764048	0.0711624422595535	418	Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3	'de novo' cotranslational protein folding	unfolded protein binding	nascent polypeptide-associated complex|CCR4-NOT complex
YOR210W	RPB10	het	FF|FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0311415692135211	0.0712583621498136	419	RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III	transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase II, core complex
YHL022C	SPO11	hom	FT	CELL CYCLE|NUCLEUS|CHROMOSOME	0.0311330841947386	0.0713355054698708	420	Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation	meiotic DNA double-strand break formation	endodeoxyribonuclease activity, producing 3'-phosphomonoesters	nuclear chromosome
YDL212W	SHR3	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH	0.0311329847719112	0.0713364097986505	421	Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface	protein folding|ER to Golgi vesicle-mediated transport	unfolded protein binding	integral to endoplasmic reticulum membrane|integral to membrane|mating projection tip
YDR244W	PEX5	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION	0.0311277574043834	0.0713839700459933	422	Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions	protein import into peroxisome matrix, docking	peroxisome matrix targeting signal-1 binding|protein binding, bridging	cytosol|peroxisomal membrane|peroxisome
YDL229W	SSB1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS	0.0310935753287593	0.071695610063666	423	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication	cytoplasmic translation|cellular response to glucose starvation|translational termination|ribosomal subunit export from nucleus|regulation of translational fidelity|rRNA processing|'de novo' cotranslational protein folding	unfolded protein binding|ATPase activity|calmodulin binding	plasma membrane|polysome|cytoplasm
YKL215C	OXP1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0310777015996897	0.0718407101833038	424	5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	glutathione metabolic process	5-oxoprolinase (ATP-hydrolyzing) activity	cytoplasm
YOR101W	RAS1	hom	FT	SIGNALING|NUCLEOTIDE METABOLISM|PLASMA MEMBRANE	0.0310657102615046	0.0719929012258001	425	GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress	adenylate cyclase-activating G-protein coupled receptor signaling pathway|replicative cell aging|Ras protein signal transduction	GTPase activity	plasma membrane
YPR001W	CIT3	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0310626825268698	0.0719782192788048	426	Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate	propionate catabolic process, 2-methylcitrate cycle|propionate metabolic process|tricarboxylic acid cycle	2-methylcitrate synthase activity|citrate (Si)-synthase activity	mitochondrion
YBL054W	TOD6	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|CHROMOSOME	0.0310467062496813	0.0721247286364892	427	PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	Rpd3L-Expanded complex|nucleus|Rpd3L complex|cytoplasm
YHR156C	LIN1	hom	FT	NUCLEUS|CHROMOSOME	0.0310201443785299	0.0723688527250513	428	Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication	biological_process	protein binding	chromatin|nucleus|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YBL001C	ECM15	hom	FT	CELL WALL ORG/BIOGENESIS|NUCLEUS	0.0310190596212518	0.072421399568678	429	Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis	fungal-type cell wall organization	molecular_function	nucleus|cytoplasm
YIL057C	RGI2	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.030997683337921	0.0725758143375704	430	Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose	energy reserve metabolic process	molecular_function	cytoplasm
YHR048W_p	YHK8	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.0309421491934838	0.0730895992517181	431	Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles	drug transport	molecular_function	integral to membrane
YLR396C	VPS33	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	0.030936104451382	0.0731457024216031	432	ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole	regulation of SNARE complex assembly|endocytosis|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle fusion with vacuole|Golgi to vacuole transport|vacuole organization|vacuole fusion, non-autophagic|vesicle docking|protein targeting to vacuole	phosphatidylinositol binding|ATP binding	cytosol|fungal-type vacuole membrane|HOPS complex|fungal-type vacuole|CORVET complex
YLR419W_p	YLR419W	hom	FT	MITOCHONDRION	0.0309345009110785	0.07316059129688	433	Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene	biological_process	molecular_function	mitochondrion|cytoplasm
YPL049C	DIG1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0308656776634136	0.073801954779717	434	MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p	negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown	DNA binding|transcription factor binding	nucleus
YDR041W	RSM10	het	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0307804683076413	0.0746023787415309	435	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YOR233W	KIN4	hom	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0306958052313431	0.0756227127698494	436	Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication	mitotic cell cycle spindle orientation checkpoint|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cell cortex|spindle pole body|cellular bud neck
YDR441C	APT2	hom			0.030626388137486	0.0760677407179061	437	Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication	biological_process	adenine phosphoribosyltransferase activity|molecular_function	cytoplasm
YOR113W	AZF1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL WALL ORG/BIOGENESIS|NUCLEUS	0.0305692596665787	0.0766169837461298	438	Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity	regulation of fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|cellular response to carbohydrate stimulus	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YGL057C	GEP7	hom	FT	MITOCHONDRION	0.0305276236837083	0.0770193119562579	439	Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YCL005W	LDB16	hom	FT	MITOCHONDRION	0.0305173537820552	0.0771188141095354	440	Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria	biological_process	molecular_function	mitochondrion|lipid particle
YIR023W	DAL81	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0304509449615748	0.0777647606443642	441	Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism	nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process|urea catabolic process	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YLR240W	VPS34	hom	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION|GOLGI APPARATUS	0.030420976396097	0.0780576982281525	442	Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery	peroxisome degradation|phosphatidylinositol phosphorylation|protein phosphorylation	1-phosphatidylinositol-3-kinase activity|protein kinase activity	endosome|fungal-type vacuole membrane|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|peroxisome|pre-autophagosomal structure
YDL131W	LYS21	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS|MITOCHONDRION	0.0304042566865291	0.0782215203955258	443	Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication	lysine biosynthetic process via aminoadipic acid	homocitrate synthase activity	nucleus
YPL137C	GIP3	hom	FT	CHROMOSOME SEGREGATION|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0303908747184021	0.0783528403485361	444	Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication	chromosome segregation|regulation of phosphoprotein phosphatase activity	protein phosphatase type 1 regulator activity|protein phosphatase 1 binding	mitochondrion|ribosome|endoplasmic reticulum|cytoplasm
YPL264C_p	YPL264C	hom			0.0303814238261123	0.0784456918850619	445	Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene	biological_process	molecular_function	integral to membrane
YKL033W-A_p	YKL033W-A	hom			0.0303411542833488	0.0788423290690208	446	Putative protein of unknown function; similar to uncharacterized proteins from other fungi	biological_process	molecular_function	cellular_component
YMR075W	RCO1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.0303276321850268	0.0789758809351371	447	Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p	regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|transcription elongation from RNA polymerase II promoter|histone deacetylation	molecular_function	Rpd3S complex|histone deacetylase complex|nucleus|Rpd3L complex
YDL061C	RPS29B	hom	FT	TRANSLATION|RIBOSOME	0.0302865317427879	0.0793829416335065	448	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YHR006W	STP2	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|PLASMA MEMBRANE	0.0302770369627535	0.0794772204378617	449	Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YLL007C_p	YLL007C	hom			0.0302691610261986	0.079555493898534	450	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene	biological_process	molecular_function	cytoplasm
YPR025C	CCL1	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|NUCLEUS|MITOCHONDRION|RNA POL II, HOLOENZYME	0.0302691484545847	0.0795556188891265	451	Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters	phosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity|cyclin-dependent protein kinase regulator activity	mitochondrion|holo TFIIH complex|TFIIK complex
YDL105W	NSE4	het	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0302329016730572	0.0800967216435074	452	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair	DNA repair	molecular_function	Smc5-Smc6 complex|nucleus
YBR004C	GPI18	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0301904371758528	0.0803413228774839	453	Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria	GPI anchor biosynthetic process	mannosyltransferase activity|dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity	integral to endoplasmic reticulum membrane|mitochondrion|mannosyltransferase complex|integral to membrane|endoplasmic reticulum
YMR218C	TRS130	het	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|GOLGI APPARATUS	0.0301329388848788	0.0811459343547333	454	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy	regulation of Rab GTPase activity|early endosome to Golgi transport|intra-Golgi vesicle-mediated transport	Rab guanyl-nucleotide exchange factor activity	TRAPP complex|trans-Golgi network|early endosome
YPL012W	RRP12	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|RIBOSOME	0.0300770195831774	0.0814845378163613	455	Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosome biogenesis	molecular_function	ribosome|nucleus|90S preribosome
YLR217W_d	YLR217W	hom			0.0300544841903266	0.0818499043010796	456	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6	Unknown	Unknown	Unknown
YHR138C	YHR138C	hom	FT	MEMBRANE ORGANIZATION	0.0299840431238512	0.0824315231532653	457	Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress	vacuole fusion, non-autophagic	endopeptidase inhibitor activity	cellular_component
YNL175C	NOP13	hom	FT	NUCLEUS	0.0299495472109749	0.0827851318093327	458	Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress	biological_process	RNA binding	nucleolus|preribosome
YDL002C	NHP10	hom	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0299265823994084	0.0830212187242206	459	Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair	double-strand break repair|nucleosome mobilization	DNA end binding|loop DNA binding	nucleus|Ino80 complex
YHR203C	RPS4B	hom	FT	TRANSLATION|RIBOSOME	0.0298856580571091	0.0834432878712883	460	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YNL034W_p	YNL034W	hom			0.0298037144585604	0.0842936262194255	461	Putative protein of unknown function; YNL034W is not an essential gene	biological_process	molecular_function	cellular_component
YOL014W_p	YOL014W	hom			0.0298031308635455	0.0845314664156593	462	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKL120W	OAC1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.0297922842587658	0.0844591240553131	463	Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family	sulfate transport|oxaloacetate transport|isopropylmalate transport	secondary active sulfate transmembrane transporter activity|oxaloacetate secondary active transmembrane transporter activity|isopropylmalate transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDR412W	RRP17	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0297817500441361	0.0845227408777515	464	Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5&#8242; end processing of pre-60S ribosomal RNA	rRNA processing	molecular_function	cytoplasm
YFL001W	DEG1	hom	FT	RNA PROCESSING|NUCLEUS	0.0296861055387402	0.0859472075045236	465	tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability	tRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus|cytoplasm
YOL072W	THP1	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0296589583538514	0.0858128962939191	466	Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding	mRNA export from nucleus|mRNA 3'-end processing|transcription-coupled nucleotide-excision repair|cellular bud site selection|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|transcription elongation from RNA polymerase II promoter	double-stranded DNA binding|RNA binding	nuclear envelope|nucleus|transcription export complex 2|nuclear pore
YKL162C-A_d	YKL162C-A	hom			0.0295892435160082	0.0865524307660384	467	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL084W	BRO1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.0295303168191485	0.0871815289195566	468	Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes	protein deubiquitination|vacuolar transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|response to nutrient|ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	endosome|cytoplasm
YJL128C	PBS2	hom	FF|FT	PROTEIN LOCALIZATION|SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH	0.0295212367938484	0.0872787939296678	469	MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition	activation of MAPK activity involved in osmosensory signaling pathway|actin filament organization|MAPK import into nucleus involved in osmosensory signaling pathway|protein phosphorylation|hyperosmotic response|osmosensory signaling pathway|cellular response to heat	MAP-kinase scaffold activity|MAP kinase kinase activity|protein kinase activity	cellular bud neck|cytoplasm|cellular bud tip
YER180C-A	SLO1	hom	FT	PROTEIN LOCALIZATION	0.0295137070882084	0.0873595183242521	470	Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO	intracellular protein transport	small GTPase regulator activity	cytoplasm
YJL103C	GSM1	hom	FT	TRANSCRIPTION FROM RNA POL II|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.0295014421988828	0.0874911365496319	471	Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis	oxidative phosphorylation	sequence-specific DNA binding|DNA binding	cellular_component
YDR267C	CIA1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|COFACTOR METABOLISM|NUCLEUS	0.0294940892394371	0.0877592747915519	472	Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein	iron-sulfur cluster assembly|ribosomal large subunit export from nucleus|tRNA wobble uridine modification	molecular_function	cytosol|nucleus|cytoplasm
YGR131W	FHN1	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PLASMA MEMBRANE	0.0294287904654668	0.0882740668072519	473	Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain	establishment of protein localization to plasma membrane	molecular_function	integral to membrane|membrane raft
YGR210C_p	YGR210C	hom			0.0293796667777671	0.0888066396357543	474	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YDR023W	SES1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.0293719178951688	0.0888908847147464	475	Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p	seryl-tRNA aminoacylation	serine-tRNA ligase activity	cytoplasm
YMR185W	RTP1	het			0.0293510018667804	0.0891186030596992	476	Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene	biological_process	molecular_function	cellular_component
YDR153C	ENT5	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM	0.0293178087193063	0.0894809496408087	477	Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin	late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|Golgi to endosome transport	clathrin binding|phosphatidylinositol-3,5-bisphosphate binding	endosome|clathrin vesicle coat|cytoplasm
YBR042C	CST26	hom	FT	LIPID METABOLISM	0.0292982211650969	0.0896953291586434	478	Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication	phospholipid biosynthetic process	transferase activity, transferring acyl groups	lipid particle
YGR067C_p	YGR067C	hom	FT	NUCLEUS	0.0292961698233759	0.0900533738438322	479	Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p	biological_process	sequence-specific DNA binding	cellular_component
YPR007C	REC8	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.0292869149186712	0.0898192604385911	480	Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p	synaptonemal complex assembly|protein localization to chromosome, centromeric region|reciprocal meiotic recombination|meiotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome|condensed nuclear chromosome, centromeric region
YDR457W	TOM1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|PROTEOLYSIS|RNA LOCALIZATION|NUCLEUS	0.0292783958200009	0.0899127319199826	481	E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mitosis|nucleocytoplasmic transport|nucleus organization|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell size|protein ubiquitination	ubiquitin-protein ligase activity	integral to membrane|nucleolus|nucleus
YBR011C	IPP1	het			0.0292389991021556	0.0903940415713897	482	Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase	phosphate-containing compound metabolic process	inorganic diphosphatase activity|protein homodimerization activity	cytosol
YDR480W	DIG2	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0291677442990136	0.0911339236538675	483	MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p	negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown	transcription factor binding	nucleus
YDL168W	SFA1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0291570751964141	0.0913006553664833	484	Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress	furaldehyde metabolic process|formaldehyde catabolic process|amino acid catabolic process to alcohol via Ehrlich pathway	S-(hydroxymethyl)glutathione dehydrogenase activity|hydroxymethylfurfural reductase (NADH) activity|alcohol dehydrogenase (NAD) activity	mitochondrion|cytoplasm
YHR118C	ORC6	het	FT	GENE SILENCING|NUCLEUS|CHROMOSOME	0.0291419909618372	0.09142005088984	485	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p	DNA replication initiation|pre-replicative complex assembly|chromatin silencing at silent mating-type cassette	DNA replication origin binding	pre-replicative complex|DNA replication preinitiation complex|nuclear origin of replication recognition complex
YDR018C_p	YDR018C	hom	FT	LIPID METABOLISM	0.0290885128799113	0.0920165137711007	486	Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication	phospholipid biosynthetic process	transferase activity, transferring acyl groups	integral to membrane
YHR148W	IMP3	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.029070941389534	0.0922131764616836	487	Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA	rRNA processing|ribosome biogenesis	snoRNA binding	small-subunit processome|Mpp10 complex|90S preribosome
YML003W_p	YML003W	hom			0.0289635231822199	0.0934227645502756	488	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YFL034W_p	YFL034W	hom			0.0289549356694756	0.0936668002292864	489	Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk	biological_process	molecular_function	integral to membrane
YOR170W_d	YOR170W	hom			0.0289540920396678	0.0935295692113979	490	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4	Unknown	Unknown	Unknown
YCR089W	FIG2	hom	FT	CELL WALL ORG/BIOGENESIS	0.02891902293328	0.0940256260871103	491	Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating	filamentous growth of a population of unicellular organisms|cell morphogenesis involved in conjugation with cellular fusion|invasive growth in response to glucose limitation|cytogamy	molecular_function	fungal-type cell wall|mating projection
YJL183W	MNN11	hom	FT	CARBOHYDRATE METABOLISM|GOLGI APPARATUS	0.028908830157422	0.0941907210188365	492	Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p	protein glycosylation	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YIR010W	DSN1	het	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.028883265756399	0.0943347860290969	493	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation	chromosome segregation	molecular_function	nuclear MIS12/MIND type complex|kinetochore|spindle pole
YNL131W	TOM22	het	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0288770422192413	0.0944058054689489	494	Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes	protein import into mitochondrial matrix|protein import into mitochondrial outer membrane	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YML020W_p	YML020W	hom			0.0288355411919313	0.0948804873300924	495	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YML037C_p	YML037C	hom			0.0287946521841389	0.0953994286631646	496	Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene	biological_process	molecular_function	clathrin-coated vesicle
YJL135W_d	YJL135W	hom			0.0287772530604393	0.0955504027732297	497	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3	Unknown	Unknown	Unknown
YIL154C	IMP2'	hom	FF|FT	RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS	0.0287685118117438	0.0961471698835288	498	Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat	DNA repair|cellular carbohydrate metabolic process	transcription coactivator activity	cytoplasm
YGR259C_d	YGR259C	hom			0.0287167872194548	0.0963983159271912	499	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W	Unknown	Unknown	Unknown
YDR157W_d	YDR157W	hom			0.028622151536529	0.0973514611470002	500	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL031W	ULP2	het	FT	CELL CYCLE|PROTEOLYSIS|NUCLEUS	0.0286161193955546	0.097422051399866	501	Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate	plasmid maintenance|protein desumoylation|chromosome condensation|mitotic cell cycle spindle assembly checkpoint	cysteine-type peptidase activity|SUMO-specific protease activity	nucleus
YBR214W	SDS24	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION	0.0285838328215191	0.0978005758503387	502	Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication	endocytosis|cytokinetic cell separation	molecular_function	cytoplasm
YPL002C	SNF8	hom	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.0285736761385369	0.0979198943322779	503	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression	negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	molecular_function	ESCRT II complex
YJL149W	DAS1	hom	FT	PROTEOLYSIS|UBIQUITIN LIGASE COMPLEX	0.028571594275528	0.0979443659525631	504	Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YER075C	PTP3	hom	FT	PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0285664703994522	0.0980046162464984	505	Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm	inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of sporulation|regulation of protein localization|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion	protein tyrosine phosphatase activity	nucleus|cytoplasm
YMR002W	MIC17	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS|MITOCHONDRION	0.0285395110940557	0.0983221112125323	506	Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	aerobic respiration	molecular_function	nucleus|cytoplasm|mitochondrial intermembrane space
YDR124W_p	YDR124W	hom			0.0284566897231504	0.0996055792487028	507	Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor	biological_process	molecular_function	cellular_component
YMR171C	EAR1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	0.028406749483395	0.0998976168719405	508	Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	molecular_function	endosome
YKL091C	YKL091C	hom	FT	NUCLEUS	0.0283905472309544	0.100091262084432	509	Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study	biological_process	phosphatidylcholine binding|phosphatidylinositol transporter activity|phosphatidylinositol binding|phosphatidylcholine transporter activity	nucleus
YOR300W_d	YOR300W	hom			0.0283185383509483	0.100955516036592	510	Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7	Unknown	Unknown	Unknown
YEL052W	AFG1	hom	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|RESPONSE TO OXIDATIVE STRESS|PEROXISOME ORGANIZATION|MITOCHONDRION	0.0283168066258305	0.100976373230512	511	Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain	protein import into peroxisome matrix|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process	molecular_function	mitochondrion|mitochondrial inner membrane
YKL069W	YKL069W	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0282988195796181	0.101244117865947	512	Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress	cellular response to oxidative stress	methionine-R-sulfoxide reductase activity	nucleus|cytoplasm
YGR235C	MOS2	hom	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0282723812708742	0.101665646323878	513	Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YIR020C_p	YIR020C	hom			0.0282483680764298	0.101803409954692	514	Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YML090W_d	YML090W	hom			0.0282183337439438	0.102168053591095	515	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source	Unknown	Unknown	Unknown
YBR090C_p	YBR090C	hom	FT	NUCLEUS	0.0281714170067993	0.103099353022917	516	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YBR178W_d	YBR178W	hom			0.0281125889366144	0.103460164882714	517	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C	Unknown	Unknown	Unknown
YJR015W_p	YJR015W	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0280966696826884	0.103655804135997	518	Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum|cytoplasm
YMR230W-A_p	YMR230W-A	hom			0.0280507490255446	0.104221791728008	519	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YCR032W	BPH1	hom	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS|MITOCHONDRION	0.0280401644680413	0.104352597314408	520	Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting	intracellular protein transport|fungal-type cell wall organization|response to pH	molecular_function	cytosol|mitochondrion|extrinsic to membrane
YER005W	YND1	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|GOLGI APPARATUS	0.0279931449727279	0.104935247630484	521	Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity	protein glycosylation	nucleoside-triphosphatase activity|nucleoside-diphosphatase activity	COPI-coated vesicle|Golgi apparatus|membrane|Golgi membrane
YLL052C	AQY2	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.0279849682966759	0.105036833319328	522	Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains	water transport	water channel activity	plasma membrane|endoplasmic reticulum membrane
YBL064C	PRX1	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.0278817748797412	0.106586704110376	523	Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress	response to cadmium ion|cellular response to oxidative stress|cell redox homeostasis	thioredoxin peroxidase activity	mitochondrion
YMR010W_p	YMR010W	hom			0.0278603646461282	0.106594562676894	524	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1	biological_process	molecular_function	integral to membrane|cytoplasm
YCR020W-B	HTL1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|RSC COMPLEX	0.0278585681534497	0.107088261399649	525	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance	regulation of cell cycle|nucleosome disassembly|response to DNA damage stimulus|chromatin remodeling|transcription elongation from RNA polymerase II promoter	chromatin binding	RSC complex
YPL166W	ATG29	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	0.0278473198992435	0.106863255292208	526	Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy	molecular_function	pre-autophagosomal structure|cytoplasm
YGR288W	MAL13	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|NUCLEUS	0.0277832787182871	0.107567377931131	527	MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C	cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent	sequence-specific DNA binding transcription factor activity	nucleus
YGR251W	NOP19	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0277601615845618	0.107860479180629	528	Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleoplasm|nucleolus|nucleus|90S preribosome
YNL253W	TEX1	hom	FT	RNA LOCALIZATION|NUCLEUS	0.0277458644229539	0.108042068422489	529	Protein involved in mRNA export, component of the transcription export (TREX) complex	mRNA export from nucleus	molecular_function	transcription export complex
YDR391C_p	YDR391C	hom	FT	NUCLEUS	0.0277249183682666	0.108361176413849	530	Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YCR067C	SED4	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0276997323995556	0.108840650907519	531	Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p	positive regulation of GTPase activity|regulation of COPII vesicle coating	Sar GTPase activator activity	integral to endoplasmic reticulum membrane
YMR057C_d	YMR057C	hom			0.0276978020017988	0.10865428644499	532	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1	Unknown	Unknown	Unknown
YER113C	TMN3	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.027685108150963	0.108816437532688	533	Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation	cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|invasive growth in response to glucose limitation	molecular_function	COPI-coated vesicle|integral to membrane|Golgi apparatus
YLR317W_d	YLR317W	het			0.027684844557309	0.10903099166666	534	Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C	Unknown	Unknown	Unknown
YKL160W	ELF1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS	0.027676297093375	0.108981881988945	535	Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression	regulation of transcription by chromatin organization|transcription elongation from RNA polymerase II promoter	RNA polymerase II core binding	transcription elongation factor complex|nucleus
YDR397C	NCB2	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0276668736764135	0.109049699234517	536	Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity|transcription corepressor activity	nucleus|negative cofactor 2 complex
YPR045C	THP3	hom	FT	RNA PROCESSING|NUCLEUS|CHROMOSOME	0.0276069742680972	0.109818736007174	537	Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes	mRNA splicing, via spliceosome	molecular_function	nucleus|transcriptionally active chromatin
YNL230C	ELA1	hom	FT	PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0275595154270132	0.110431087490546	538	Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	elongin complex|Cul3-RING ubiquitin ligase complex
YFL047W	RGD2	hom	FT	SIGNALING|SITE OF POLARIZED GROWTH	0.0275479669231632	0.110580502470234	539	GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress	small GTPase mediated signal transduction	Rho GTPase activator activity	cellular bud neck|cytoplasm
YJR118C	ILM1	hom	FF|FT	MITOCHONDRION ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0275368462258002	0.110724533258431	540	Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth	mitochondrial genome maintenance	molecular_function	integral to membrane|endoplasmic reticulum
YMR180C	CTL1	hom	FT	RNA PROCESSING|NUCLEUS	0.0274909175968469	0.111320951547815	541	RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm	biological_process	polynucleotide 5'-phosphatase activity	nucleus|cytoplasm
YPL063W	TIM50	het	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0274711125102307	0.111578916495707	542	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel	protein import into mitochondrial matrix	mitochondrion targeting sequence binding|protein channel activity	mitochondrion|mitochondrial inner membrane presequence translocase complex
YLR310C	CDC25	het	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEUS|PLASMA MEMBRANE	0.0274690630117578	0.111819400919481	543	Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1	regulation of cell cycle|replicative cell aging|Ras protein signal transduction|traversing start control point of mitotic cell cycle	Ras guanyl-nucleotide exchange factor activity	cytosol|nucleus|plasma membrane|cytoplasm
YDL196W_d	YDL196W	het	FF		0.0274463384246812	0.112062749570454	544	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31	Unknown	Unknown	Unknown
YAR015W	ADE1	hom	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.0274431362022525	0.111997591797186	545	N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	nucleus|cytoplasm
YHR022C-A_p	YHR022C-A	hom			0.0273610805810342	0.113020699010337	546	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YBR222C	PCS60	hom			0.0273324432649376	0.113398339102668	547	Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase	biological_process	mRNA binding|AMP binding	integral to membrane|peroxisomal matrix|peroxisomal membrane|cytoplasm
YLR282C_d	YLR282C	hom			0.0273304868229106	0.11358568978261	548	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition	Unknown	Unknown	Unknown
YDR022C	ATG31	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|CHROMOSOME SEGREGATION|CYTOSKELETON	0.0272904652739013	0.113953697399866	549	Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion	autophagy|mitochondrion degradation|piecemeal microautophagy of nucleus	molecular_function	pre-autophagosomal structure|cytoplasm
YAL066W_d	YAL066W	hom			0.0272664149332439	0.114651431777107	550	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL095C	EEB1	hom	FT	KETONE METABOLISM|LIPID METABOLISM	0.0272337065186934	0.114708002634562	551	Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication	medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process	short-chain carboxylesterase activity|alcohol O-octanoyltransferase activity	cellular_component
YLR319C	BUD6	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0272275990185343	0.114789402774052	552	Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate	bipolar cellular bud site selection|positive regulation of formin-nucleated actin cable assembly|cellular bud site selection|Rho protein signal transduction|extrachromosomal circular DNA localization involved in cell aging|establishment of cell polarity|response to osmotic stress|cytokinesis	cytoskeletal regulatory protein binding	polarisome|actin cap|spindle pole body|mating projection tip
YPR174C	YPR174C	hom	FT	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON	0.027199354162497	0.115166438296969	553	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication	biological_process	molecular_function	nuclear envelope|spindle pole body
YKL064W	MNR2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.0271984816439066	0.115178100874764	554	Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations	cellular magnesium ion homeostasis	magnesium ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YER181C_d	YER181C	hom			0.0271926807836724	0.115255662066792	555	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies	Unknown	Unknown	Unknown
YFL034C-A	RPL22B	hom	FT	TRANSLATION|RIBOSOME	0.0271734796449137	0.1155126864098	556	Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YPL038W	MET31	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0271555958876517	0.11575248138891	557	Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication	regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YGR239C	PEX21	hom	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	0.0270964065684587	0.116548913777257	558	Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress	protein import into peroxisome matrix|positive regulation of protein binding	protein binding	cytosol|peroxisome
YLR280C_d	YLR280C	hom			0.0270830218990224	0.116729608698945	559	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR173W	DCS2	hom			0.0270315529824465	0.117426495913036	560	Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance	deadenylation-dependent decapping of nuclear-transcribed mRNA	m7G(5')pppN diphosphatase activity	cytoplasmic mRNA processing body|cytoplasm
YNL217W_p	YNL217W	hom			0.0270067744794465	0.11776315786839	561	Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate	biological_process	phosphatase activity	fungal-type vacuole
YIL022W	TIM44	het	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0270047597005314	0.117790565626222	562	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)	protein import into mitochondrial matrix	protein binding, bridging|chaperone binding	mitochondrion|integral to membrane|presequence translocase-associated import motor
YDR420W	HKR1	hom	FT	CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0269882450735066	0.118179951499974	563	Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection	(1->3)-beta-D-glucan biosynthetic process|fungal-type cell wall organization|osmosensory signaling pathway via Sho1 osmosensor|hyperosmotic response|cellular bud site selection	osmosensor activity	site of polarized growth|plasma membrane
YKL094W	YJU3	hom	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0269678762226909	0.118293189364302	564	Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family	triglyceride metabolic process	serine hydrolase activity|acylglycerol lipase activity	mitochondrial outer membrane|lipid particle|plasma membrane|membrane|cytoplasm
YCL023C_d	YCL023C	hom			0.0269490380343717	0.118550551667208	565	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4	Unknown	Unknown	Unknown
YML064C	TEM1	het	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON	0.0269480461779293	0.11856411429718	566	GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis	regulation of exit from mitosis	protein binding|GTPase activity	spindle pole body
YIL071C	PCI8	hom	FT	NUCLEUS	0.0269350823592661	0.11874149319988	567	Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain	cullin deneddylation	molecular_function	signalosome
YOR256C	TRE2	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	0.0269072202542786	0.119123423288812	568	Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	molecular_function	cellular_component
YBR030W	RKM3	hom	FT	NUCLEUS	0.026904405608492	0.119162059543092	569	Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein	peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	nucleus
YBR102C	EXO84	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|SITE OF POLARIZED GROWTH	0.0268914342992058	0.119340241789078	570	Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate	spliceosomal complex assembly|Golgi to plasma membrane transport|exocyst localization|exocytosis|exocyst assembly	molecular_function	incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip|exocyst
YNL144C_p	YNL144C	hom	FT	MITOCHONDRION	0.0268816403956104	0.119474915357338	571	Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study	biological_process	molecular_function	mitochondrion
YNL080C	EOS1	hom	FT	CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0268746772071352	0.119570736823771	572	Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene	cellular response to oxidative stress|protein N-linked glycosylation	molecular_function	integral to membrane|endoplasmic reticulum membrane
YMR061W	RNA14	het	FT	RNA PROCESSING|NUCLEUS|MITOCHONDRION	0.0268443430422569	0.119988872033959	573	Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping	mRNA cleavage|mRNA polyadenylation	RNA binding|protein heterodimerization activity	mRNA cleavage factor complex|mitochondrion|nucleus
YDR438W	THI74	hom	FT	MITOCHONDRION	0.0268369648483501	0.12009074812038	574	Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane
YFR017C	IGD1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0268342444872474	0.120515807764266	575	Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication	negative regulation of glycogen catabolic process	enzyme inhibitor activity	cytoplasm
YER080W	AIM9	hom	FT	MITOCHONDRION	0.0268163545275838	0.12037568851793	576	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YLL053C_p	YLL053C	hom			0.0267717639598908	0.120993969229601	577	Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin	biological_process	molecular_function	integral to membrane
YOR090C	PTC5	hom	FT	MITOCHONDRION	0.0266767529536207	0.122542727572927	578	Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p	positive regulation of catalytic activity|regulation of catalytic activity|protein dephosphorylation	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|protein serine/threonine phosphatase activity	mitochondrion
YIR003W	AIM21	hom	FT	SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0266151249281952	0.123185585719601	579	Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton	mitochondrion migration along actin filament	molecular_function	ribosome|mating projection tip|actin cytoskeleton
YGR073C_d	YGR073C	het			0.0266144328282757	0.123195337543285	580	Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein	Unknown	Unknown	Unknown
YGL103W	RPL28	het	FT	TRANSLATION|NUCLEUS|RIBOSOME	0.026466517117251	0.125293359571823	581	Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit|nucleus
YOR012W_p	YOR012W	hom			0.0264290489658884	0.126055135104418	582	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR508C	GNP1	hom	FT	MITOCHONDRION|PLASMA MEMBRANE	0.0263951664895755	0.126315292036866	583	High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity|L-proline transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YDR029W_d	YDR029W	hom			0.026379739539189	0.127960162254356	584	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR389W	SAC7	hom	FF|FT	CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0263770011078466	0.126576502414964	585	GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate	actin filament reorganization involved in cell cycle|small GTPase mediated signal transduction	Rho GTPase activator activity	intracellular
YOL013C	HRD1	hom	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX	0.0263453094117583	0.127033221538876	586	Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon	fungal-type cell wall organization|ER-associated protein catabolic process	ubiquitin-protein ligase activity	Hrd1p ubiquitin ligase ERAD-M complex|integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YEL072W	RMD6	hom	FT	CELL CYCLE	0.0263414593527431	0.127088793180878	587	Protein required for sporulation	biological_process	molecular_function	cellular_component
YGL170C	SPO74	hom	FT	NUCLEUS|CYTOSKELETON	0.0263385832007219	0.127187020876984	588	Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation	ascospore formation	structural molecule activity	spindle pole body
YOR008C-A_p	YOR008C-A	hom			0.0262975988319203	0.127893748828707	589	Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres	biological_process	molecular_function	cellular_component
YNL277W-A_p	YNL277W-A	hom			0.0262926311104128	0.127795220381516	590	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR069C	RRP4	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION|NUCLEUS	0.0262636854904347	0.128386261256184	591	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)	nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|polyadenylation-dependent snoRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YLR053C_p	YLR053C	hom			0.0262107367981263	0.12955880314129	592	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBL020W	RFT1	het	FT	MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0261943771868674	0.129225965433296	593	Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein	glycolipid translocation	molecular_function|glycolipid-translocating activity	integral to membrane|endoplasmic reticulum membrane
YNL045W	LAP2	hom	FT	KETONE METABOLISM|LIPID METABOLISM|PROTEOLYSIS|NUCLEUS	0.0261594046716899	0.129738215429512	594	Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	cellular lipid metabolic process|protein catabolic process	aminopeptidase activity|leukotriene-A4 hydrolase activity|epoxide hydrolase activity	nucleus|cytoplasm
YCL050C	APA1	hom	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.0261313818107461	0.130149808372443	595	AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication	nucleotide biosynthetic process|nucleoside catabolic process	bis(5'-nucleosyl)-tetraphosphatase activity|sulfate adenylyltransferase (ADP) activity	nucleus|cytoplasm
YPL109C_p	YPL109C	hom	FT	MITOCHONDRION	0.0261059632406939	0.13052402557859	596	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YKL073W	LHS1	hom	FT	PROTEIN LOCALIZATION|NUCLEOTIDE METABOLISM|ENDOPLASMIC RETICULUM	0.0260913512863938	0.130739523042595	597	Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway	posttranslational protein targeting to membrane, translocation|response to unfolded protein	unfolded protein binding|adenyl-nucleotide exchange factor activity|ATP binding	endoplasmic reticulum lumen
YBR027C_d	YBR027C	hom			0.0259873587035787	0.132281184798528	598	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR077C	PAT1	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|TRANSLATION|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|RIBOSOME	0.0259695989306617	0.132661390867652	599	Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|chromosome segregation|regulation of translational initiation|formation of translation preinitiation complex|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly	molecular_function	cytosolic small ribosomal subunit|cytoplasmic mRNA processing body
YKL088W	CAB3	het	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.0259491384654599	0.132851313579399	600	Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC	response to salt stress|coenzyme A biosynthetic process	phosphopantothenoylcysteine decarboxylase activity|purine nucleotide binding	phosphopantothenoylcysteine decarboxylase complex|cytoplasm
YER170W	ADK2	hom	FT	NUCLEOTIDE METABOLISM|MITOCHONDRION	0.0259112719310843	0.133707869924667	601	Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background	nucleotide metabolic process	nucleoside triphosphate adenylate kinase activity|adenylate kinase activity	mitochondrion|mitochondrial inner membrane
YNL334C	SNO2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0258777904640077	0.134094787858906	602	Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin	pyridoxine metabolic process|thiamine biosynthetic process	molecular_function	cellular_component
YMR200W	ROT1	het	FT	CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|CYTOSKELETON ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0258047138028051	0.135022869161545	603	Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation	budding cell apical bud growth|cell cycle cytokinesis|establishment or maintenance of actin cytoskeleton polarity|protein O-linked mannosylation|endoplasmic reticulum unfolded protein response|protein folding|fungal-type cell wall biogenesis|'de novo' protein folding|protein N-linked glycosylation	unfolded protein binding	endoplasmic reticulum|endoplasmic reticulum membrane
YDL072C	YET3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0257847750839403	0.13532480750152	604	Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YLR113W	HOG1	hom	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0257825940857285	0.135357866659472	605	Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase II promoter by pheromones|protein phosphorylation|hyperosmotic response|response to arsenic-containing substance|osmosensory signaling pathway|positive regulation of transcription from RNA polymerase II promoter|cellular response to heat	MAP kinase activity	nucleus|cytoplasm
YNL278W	CAF120	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|SITE OF POLARIZED GROWTH	0.025756265608306	0.135757440942866	606	Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter	molecular_function	CCR4-NOT complex
YER057C	HMF1	hom	FT	NUCLEUS	0.0257293357616101	0.136167083228304	607	Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro	biological_process	molecular_function	cytosol|nucleus|cytoplasm
YDL098C	SNU23	het	FT	RNA PROCESSING|NUCLEUS	0.0257178175206925	0.136576545979182	608	Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome	mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YFR053C	HXK1	hom	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0256729924019916	0.137027232705786	609	Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication	mannose metabolic process|glucose import|glycolysis|fructose import|glucose metabolic process|fructose metabolic process	hexokinase activity	cytosol|mitochondrion|cytoplasm
YDR165W	TRM82	hom	FT	RNA PROCESSING|NUCLEUS	0.0256681055763377	0.137102033003837	610	Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p	tRNA methylation	tRNA (guanine-N7-)-methyltransferase activity	tRNA methyltransferase complex|nucleus
YKL156W	RPS27A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0256668798300415	0.137179389280549	611	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasm
YER086W	ILV1	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0256466258281727	0.137431186565313	612	Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation	threonine catabolic process|isoleucine biosynthetic process	L-threonine ammonia-lyase activity	mitochondrion
YLR070C	XYL2	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM	0.0256369369255651	0.137579857554409	613	Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect	xylulose biosynthetic process	D-xylulose reductase activity	cellular_component
YOR350C	MNE1	hom	FT	RNA PROCESSING|MITOCHONDRION	0.0256161806652173	0.137898768341989	614	Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA	Group I intron splicing	molecular_function	mitochondrion|ribonucleoprotein complex|mitochondrial matrix
YOR105W_p	YOR105W	hom			0.025575842971874	0.138520167844263	615	Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YOL149W	DCP1	het	FT	RNA PROCESSING	0.0255713073700819	0.138590173132362	616	Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA	mRNA binding|enzyme activator activity|m7G(5')pppN diphosphatase activity	cytoplasmic mRNA processing body
YKR020W	VPS51	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL DIVISION|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0255574410223356	0.138922173471074	617	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p	vesicle organization|retrograde transport, endosome to Golgi|budding cell apical bud growth|regulation of cell size|protein targeting to vacuole	protein binding	Golgi apparatus|GARP complex
YHR024C	MAS2	het	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0255095594462951	0.139545940939359	618	Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins	protein processing involved in protein targeting to mitochondrion	metalloendopeptidase activity	mitochondrion|mitochondrial processing peptidase complex
YOR239W	ABP140	hom	FT	RNA PROCESSING|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0255071730668113	0.139582980137483	619	AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift	actin filament bundle assembly|tRNA methylation	tRNA (cytosine-3-)-methyltransferase activity|actin filament binding|protein binding, bridging	actin filament|actin filament bundle|mating projection tip|actin cortical patch
YPL269W	KAR9	hom	FT	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0254704097701864	0.140332013813104	620	Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase	nuclear migration along microtubule|establishment of spindle localization	molecular_function	cell cortex|spindle pole body|mating projection tip
YPL082C	MOT1	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0254442742745359	0.140561966895555	621	Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA	regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of transcription from RNA polymerase II promoter|rRNA processing	TBP-class protein binding|ATPase activity	nuclear chromosome|mitochondrion
YGL112C	TAF6	het	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE	0.0254416018401261	0.140603678528365	622	Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4	histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter	chromatin binding|RNA polymerase II activating transcription factor binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YDR482C	CWC21	hom	FT	RNA PROCESSING|NUCLEUS	0.0254268045268298	0.140894056707686	623	Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YDL048C	STP4	hom	FT	NUCLEUS|MITOCHONDRION	0.0254184674666708	0.140965159989022	624	Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress	biological_process	sequence-specific DNA binding	mitochondrion|nucleus|cytoplasm
YBL037W	APL3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE	0.0253975469560609	0.141292663671208	625	Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YAL019W	FUN30	hom	FT	CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0253966208812154	0.141307174565117	626	Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate	chromosome organization|chromatin silencing at rDNA|heterochromatin maintenance involved in chromatin silencing|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|heterochromatin assembly involved in chromatin silencing	chromatin binding|DNA-dependent ATPase activity|DNA binding|protein homodimerization activity	mitochondrion|mating-type region heterochromatin|nucleus
YEL012W	UBC8	hom	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	0.025351228723134	0.142019839603047	627	Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YNL307C	MCK1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION	0.0253172722358807	0.14255476425198	628	Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family	meiosis|double-strand break repair via nonhomologous end joining|ascospore formation|protein phosphorylation|response to stress|mitotic sister chromatid segregation	protein serine/threonine/tyrosine kinase activity|protein serine/threonine kinase activity|protein kinase activity	cellular_component
YER174C	GRX4	hom	FT	ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0252795992202248	0.143150043900655	629	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription is regulated by Yap5	cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization	disulfide oxidoreductase activity	nucleus
YGL072C_d	YGL072C	hom	FF		0.0251908761887838	0.144559506382785	630	Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	Unknown	Unknown	Unknown
YDR214W	AHA1	hom	FT	NUCLEOTIDE METABOLISM	0.0251297152630298	0.145717520297417	631	Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress	protein folding|response to stress	ATPase activator activity|chaperone binding	cytoplasm
YLR114C	AVL9	hom	FT	VESICLE-MEDIATED TRANSPORT	0.0250796918652377	0.146340769138829	632	Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress	post-Golgi vesicle-mediated transport	molecular_function	cytoplasm
YEL031W	SPF1	hom	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS	0.0250441378551102	0.147215568947091	633	P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1	cellular calcium ion homeostasis|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	mitochondrion|integral to membrane|endoplasmic reticulum membrane|cis-Golgi network
YOR080W	DIA2	hom	FT	CELL CYCLE|PROTEOLYSIS|NUCLEUS|CHROMOSOME|UBIQUITIN LIGASE COMPLEX	0.0250267537806736	0.14719475695714	634	Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA replication|invasive growth in response to glucose limitation|protein ubiquitination	ubiquitin-protein ligase activity|DNA replication origin binding	SCF ubiquitin ligase complex|nucleus|nuclear replication fork
YIL090W	ICE2	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0250049881996371	0.1475469783025	635	Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells	endoplasmic reticulum inheritance	molecular_function	integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum
YCL061C	MRC1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0249926301065231	0.147747249440447	636	S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres	maintenance of DNA repeat elements|intra-S DNA damage checkpoint|DNA repair|DNA replication checkpoint|telomere maintenance|replication fork protection|DNA replication|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	molecular_function	nuclear chromosome|replication fork protection complex|nucleus|nuclear replication fork
YBR177C	EHT1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|MITOCHONDRION	0.0249229557592826	0.148880256187689	637	Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication	medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process|cellular lipid metabolic process	short-chain carboxylesterase activity|alcohol O-butanoyltransferase activity|serine hydrolase activity	mitochondrial outer membrane|mitochondrion|lipid particle
YML072C	TCB3	hom	FT	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE	0.0248300113807205	0.150401974074681	638	Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact	biological_process	lipid binding	mitochondrion|cortical endoplasmic reticulum|cellular bud
YNL022C_p	YNL022C	hom	FT	NUCLEUS	0.0247797967525329	0.151229022467408	639	Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis	biological_process	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YFR038W	IRC5	hom	FT	NUCLEUS	0.0247791562909085	0.151239593365831	640	Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci	mitotic recombination	molecular_function	cellular_component
YBR146W	MRPS9	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0247708925501697	0.151376037905082	641	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YDR234W	LYS4	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0247351691147243	0.151966954427888	642	Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway	lysine biosynthetic process via aminoadipic acid	homoaconitate hydratase activity	mitochondrion
YKR069W	MET1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	0.0247198877956892	0.152220264665914	643	S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis	siroheme biosynthetic process|methionine biosynthetic process|sulfate assimilation	uroporphyrin-III C-methyltransferase activity	intracellular
YKL154W	SRP102	het	FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.02469654150714	0.152607883762987	644	Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane	protein targeting to ER|SRP-dependent cotranslational protein targeting to membrane	signal recognition particle binding|GTP binding|GTPase activity	integral to endoplasmic reticulum membrane|signal recognition particle receptor complex
YBR294W	SUL1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0246907373348779	0.152949354484243	645	High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates	sulfate transport|transmembrane transport	sulfate transmembrane transporter activity	integral to membrane|plasma membrane
YOR193W	PEX27	hom	FT	PEROXISOME ORGANIZATION	0.0246761605015277	0.153008126474644	646	Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p	peroxisome organization	molecular_function	peroxisomal membrane
YLR387C	REH1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RIBOSOME	0.0246688662893085	0.153252216841364	647	Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains	ribosomal large subunit biogenesis|budding cell bud growth	molecular_function	cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YMR123W	PKR1	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0246682201428386	0.154619069427938	648	V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress	vacuolar proton-transporting V-type ATPase complex assembly	molecular_function	integral to endoplasmic reticulum membrane
YDR159W	SAC3	hom	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0246659168645349	0.153608417413708	649	Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)	ribosomal small subunit biogenesis|actin filament-based process|mRNA export from nucleus|mRNA 3'-end processing|mitosis|protein export from nucleus|transcription-coupled nucleotide-excision repair|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery	protein binding	transcription export complex 2|nuclear pore
YMR244C-A	COA6	hom	FT	NUCLEUS|MITOCHONDRION	0.0246499814118681	0.154924297853587	650	Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YPR066W	UBA3	hom			0.0246243416004585	0.153811372383174	651	Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	protein neddylation	NEDD8 activating enzyme activity	cytoplasm
YLR065C	ENV10	hom	FF|FT	VACUOLAR PROTEIN PROCESSING	0.0246086102329864	0.154381914313613	652	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene	vacuolar protein processing	molecular_function	integral to membrane
YLR120C	YPS1	hom	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS|PLASMA MEMBRANE	0.0245702098255215	0.15471840639007	653	Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	fungal-type cell wall organization|protein processing	aspartic-type endopeptidase activity	fungal-type cell wall
YJL151C	SNA3	hom	FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM	0.0245639479436542	0.154823592224951	654	Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles	cellular protein catabolic process|endosome transport via multivesicular body sorting pathway	ubiquitin protein ligase binding	fungal-type vacuole lumen|integral to membrane
YGR270W	YTA7	hom	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0245618651183062	0.154858591136354	655	Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p	negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter	chromatin binding|histone binding	extrinsic to endoplasmic reticulum membrane|nucleus
YOL133W	HRT1	het	FT	CELL CYCLE|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0245494045965679	0.155068097903001	656	RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF	G2/M transition of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle	ubiquitin-protein ligase activity	SCF ubiquitin ligase complex|nucleus|cytoplasm
YBL013W	FMT1	hom	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION	0.0245258485011732	0.155464749357376	657	Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate	translational initiation|methionyl-tRNA aminoacylation	methionyl-tRNA formyltransferase activity	mitochondrion
YPL248C	GAL4	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0245191048362566	0.155578444790881	658	DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p	galactose metabolic process|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YER006W	NUG1	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0245169961011628	0.155614010146277	659	GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus	ribosomal large subunit export from nucleus|rRNA processing	RNA binding|GTPase activity	nucleolus|nucleus|preribosome, large subunit precursor
YGL196W	DSD1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0244855534969452	0.1562067769876	660	D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate	D-serine metabolic process	D-serine ammonia-lyase activity	cellular_component
YDR166C	SEC5	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH	0.0244266065098838	0.157144301837446	661	Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip	Golgi to plasma membrane transport|endoplasmic reticulum inheritance|exocytosis|exocyst assembly|vesicle fusion|vesicle docking involved in exocytosis	molecular_function	incipient cellular bud site|mating projection tip|cellular bud neck|exocyst|cellular bud tip
YHR044C	DOG1	hom	FT	CARBOHYDRATE METABOLISM	0.02440898485075	0.157443959292542	662	2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified	glucose metabolic process	2-deoxyglucose-6-phosphatase activity	cellular_component
YPL136W_d	YPL136W	hom			0.024401054041712	0.157578964359531	663	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C	Unknown	Unknown	Unknown
YHR028C	DAP2	hom	FT	PROTEOLYSIS	0.024376525499683	0.157997065255325	664	Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p	protein processing	dipeptidyl-peptidase activity	fungal-type vacuole membrane
YLR453C	RIF2	hom	FT	NUCLEUS|CHROMOSOME	0.0243230153233672	0.158974230124614	665	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation	telomere capping|telomere maintenance via telomerase	telomeric DNA binding	nuclear telomere cap complex
YLR098C	CHA4	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0243182220180039	0.158994246459034	666	DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain	positive regulation of transcription, DNA-dependent|cellular amino acid catabolic process	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YFL028C	CAF16	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM|NUCLEUS	0.0243171584120548	0.159012481730267	667	Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator	regulation of transcription from RNA polymerase II promoter	ATPase activity	CCR4-NOT complex|cytoplasm
YBR256C	RIB5	het	FT	OXIDATION-REDUCTION PROCESS	0.0243059907684451	0.15920404384404	668	Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway	riboflavin biosynthetic process	riboflavin synthase activity	cellular_component
YER087C-B	SBH1	hom	FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.024250189863496	0.160163829913909	669	Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p	posttranslational protein targeting to membrane, translocation|SRP-dependent cotranslational protein targeting to membrane, translocation	ARF guanyl-nucleotide exchange factor activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity	Sec61 translocon complex
YDL029W	ARP2	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT|MITOCHONDRION|CYTOSKELETON	0.0242418768055305	0.160307189499194	670	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity	mitochondrion inheritance|Arp2/3 complex-mediated actin nucleation|ascospore wall assembly|actin filament organization|establishment of mitochondrion localization|ATP catabolic process|CVT pathway	ATPase activity|ATP binding	Arp2/3 protein complex|mitochondrion
YPL106C	SSE1	hom			0.0242174497893293	0.16072899702555	671	ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication	protein folding|protein refolding	peptide binding|adenyl-nucleotide exchange factor activity|ATP binding	polysome|cytoplasm
YOR178C	GAC1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0242109048902766	0.161029514322073	672	Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock	meiosis|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|response to heat|mitotic cell cycle spindle assembly checkpoint	protein phosphatase type 1 regulator activity|structural molecule activity|heat shock protein binding	protein phosphatase type 1 complex
YHR185C	PFS1	hom	FT	CELL WALL ORG/BIOGENESIS|NUCLEUS|CYTOSKELETON	0.0241969221476125	0.161084117637805	673	Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation	ascospore wall assembly	molecular_function	cellular_component
YBL080C	PET112	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0241869009053447	0.161257696475999	674	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog	glutaminyl-tRNAGln biosynthesis via transamidation|mitochondrial translation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YDL166C	FAP7	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0241572861669393	0.161771481243101	675	Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D	cellular response to oxidative stress|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit export from nucleus	nucleoside-triphosphatase activity	nucleus|preribosome|cytoplasm
YGR034W	RPL26B	hom	FT	TRANSLATION|RIBOSOME	0.0240811887268572	0.16309735641468	676	Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YOR277C_d	YOR277C	hom			0.0240711127498283	0.163273526354529	677	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20	Unknown	Unknown	Unknown
YOR356W	CIR2	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0240567743482941	0.163775858509182	678	Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YGR120C	COG2	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0240503165814387	0.163637583148476	679	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	peroxisome degradation|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|retrograde transport, vesicle recycling within Golgi|CVT pathway	molecular_function	Golgi transport complex|extrinsic to membrane
YPL099C	AIM43	hom	FT	MITOCHONDRION	0.0240480499924748	0.163740126508202	680	Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YLR406C	RPL31B	hom	FT	TRANSLATION|RIBOSOME	0.0240271942899104	0.164231797558043	681	Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication	cytoplasmic translation|regulation of translational fidelity	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR070C	FMP16	hom	FT	MITOCHONDRION	0.0240052580201906	0.164428473784857	682	Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrion
YOR346W	REV1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.0239957143704173	0.164596357456551	683	Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress	error-prone translesion synthesis|error-free translesion synthesis	deoxycytidyl transferase activity|DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|replication fork
YBR272C	HSM3	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|NUCLEUS	0.0239850101832166	0.165415869775709	684	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation	mismatch repair|proteasome regulatory particle assembly	molecular_function	cytosol|proteasome regulatory particle, base subcomplex|nucleus|cytoplasm
YJL195C_d	YJL195C	het	FF		0.023952000735357	0.165366979420214	685	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6	Unknown	Unknown	Unknown
YNL335W_p	DDI3	hom			0.0239195216126149	0.166004446129341	686	Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants	biological_process	molecular_function	cellular_component
YNL082W	PMS1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.0239077797800055	0.166149303174832	687	ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL	mismatch repair|meiotic mismatch repair	double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding	nucleus|MutLalpha complex|cytoplasm
YER186C_p	YER186C	hom			0.0239025523470947	0.166241966546406	688	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR018W	ROD1	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PLASMA MEMBRANE	0.0238553644096853	0.167080195767522	689	Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication	response to drug|ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	plasma membrane
YER168C	CCA1	het	FT	RNA PROCESSING|NUCLEUS|MITOCHONDRION	0.0238327374389603	0.167483257322079	690	ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites	tRNA 3'-terminal CCA addition	tRNA adenylyltransferase activity	mitochondrion|nucleus|mitochondrial matrix|cytoplasm
YJL041W	NSP1	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0238217526881066	0.167679195301881	691	FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress	poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|ncRNA export from nucleus|ribosomal large subunit export from nucleus|tRNA export from nucleus|protein import into nucleus|ribosomal small subunit export from nucleus	nucleocytoplasmic transporter activity|phospholipid binding|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore nuclear basket|nuclear pore
YKL150W	MCR1	hom	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.0238054034521944	0.16816147231118	692	Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis	ergosterol biosynthetic process|cellular response to oxidative stress	cytochrome-b5 reductase activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane|mitochondrial intermembrane space
YPL103C	FMP30	hom	FT	LIPID METABOLISM|MITOCHONDRION	0.0237705200335218	0.168595319541019	693	Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D	N-acylphosphatidylethanolamine metabolic process|N-acylethanolamine metabolic process	NAPE-specific phospholipase D activity	mitochondrion|integral to mitochondrial inner membrane
YBR268W	MRPL37	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0237537241862154	0.168960013198536	694	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YLR253W_p	YLR253W	hom	FT	MITOCHONDRION	0.0237534021860388	0.168902250174818	695	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene	biological_process	molecular_function	mitochondrion
YBR045C	GIP1	hom	FT	CELL WALL ORG/BIOGENESIS	0.0237272832736269	0.169371381129072	696	Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p	ascospore wall assembly|regulation of phosphoprotein phosphatase activity	protein phosphatase type 1 regulator activity|protein phosphatase 1 binding	protein phosphatase type 1 complex|prospore membrane
YDL063C	SYO1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0237086558043918	0.169961307792818	697	Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	ribosomal large subunit biogenesis	molecular_function	nucleus|cytoplasm
YNL275W	BOR1	hom	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT|PLASMA MEMBRANE	0.0237004643576257	0.169854100799623	698	Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1	borate transport|protein targeting to vacuole	borate efflux transmembrane transporter activity	integral to membrane|plasma membrane|fungal-type vacuole
YFL053W	DAK2	hom	FT	CARBOHYDRATE METABOLISM	0.0236943499043664	0.16996430038172	699	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation	response to stress|glycerol catabolic process	glycerone kinase activity	cellular_component
YDR413C_d	YDR413C	het			0.0236863066278172	0.17023677359842	700	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing	Unknown	Unknown	Unknown
YLR252W_d	YLR252W	hom			0.0236821940244473	0.170183542496732	701	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism	Unknown	Unknown	Unknown
YIR018C-A_p	YIR018C-A	hom			0.0236802409640949	0.170218787423035	702	Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YML066C	SMA2	hom	FT	MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|ENDOPLASMIC RETICULUM	0.0236533067001336	0.17070540092187	703	Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation	ascospore wall assembly|spore membrane bending pathway	molecular_function	integral to membrane|prospore membrane|cytoplasm
YER176W	ECM32	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	0.0236245238767921	0.171226562296465	704	DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes	regulation of translational termination	RNA helicase activity|DNA helicase activity	polysome
YIL008W	URM1	hom	FT	RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0236090767130158	0.171506749727331	705	Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response	cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|invasive growth in response to glucose limitation|tRNA wobble uridine modification	protein tag	cytosol|nucleus|cytoplasm
YGL065C	ALG2	het	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0235912850594188	0.171829887489967	706	Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol	oligosaccharide-lipid intermediate biosynthetic process	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity|glycolipid 6-alpha-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YLL001W	DNM1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION|MITOCHONDRION	0.0235215337528666	0.173101126587897	707	Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance	mitochondrion inheritance|peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization|mitochondrion organization|protein homooligomerization	protein homodimerization activity|GTPase activity|identical protein binding	mitochondrial outer membrane|mitochondrion|peroxisome
YOR089C	VPS21	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT|MITOCHONDRION	0.0234975726304644	0.173539443198985	708	Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication	endocytosis|vacuole inheritance|protein targeting to vacuole	GTP binding|GTPase activity	mitochondrial outer membrane|late endosome|mitochondrion
YBR217W	ATG12	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	0.0234951133902967	0.174098441332408	709	Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly	Atg8 ligase activity|protein tag	Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YJL143W	TIM17	het	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0234707487201532	0.174031111167368	710	Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex	protein import into mitochondrial matrix|mitochondrial genome maintenance	protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane presequence translocase complex
YDR115W	YDR115W	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0234540296328195	0.174338088806802	711	Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrial large ribosomal subunit
YGL068W	MNP1	het	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0234256523783715	0.174860045864544	712	Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth	aerobic respiration	structural constituent of ribosome	mitochondrial nucleoid|mitochondrion
YHR108W	GGA2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0234064479252507	0.175213943909166	713	Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to vacuole transport|Golgi to endosome transport	ubiquitin binding|phosphatidylinositol-4-phosphate binding	trans-Golgi network
YGL131C	SNT2	hom	FT	NUCLEUS|CHROMOSOME	0.0233672279940002	0.175938344533736	714	DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress	biological_process	DNA binding	nucleus|Snt2C complex|cytoplasm
YHR080C	YHR080C	hom	FT	MITOCHONDRION	0.0233452500968859	0.176409751490394	715	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|ribosome
YIL161W_p	YIL161W	hom			0.023244850680391	0.178407282688234	716	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene	biological_process	molecular_function	cytoplasm
YPL016W	SWI1	het	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|RSC COMPLEX	0.0231985830321822	0.179078702718142	717	Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter|DNA-dependent DNA replication	RNA polymerase II activating transcription factor binding	SWI/SNF complex|nucleus
YLR150W	STM1	hom	FT	SIGNALING|TRANSLATION|NUCLEUS|RIBOSOME	0.0231881289172314	0.179274732786498	718	Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery	translational elongation|TOR signaling cascade|regulation of translational initiation in response to stress|telomere maintenance|anti-apoptosis	triplex DNA binding|DNA binding|telomeric DNA binding	cytosolic ribosome|polysome|cytoplasm
YPL031C	PHO85	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES A	0.0231734403031018	0.179550435358896	719	Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle	regulation of transcription involved in G1/S phase of mitotic cell cycle|negative regulation of calcium-mediated signaling|regulation of protein stability|regulation of protein localization|protein phosphorylation|response to DNA damage stimulus|negative regulation of phosphate metabolic process|fungal-type cell wall organization|regulation of establishment or maintenance of cell polarity|negative regulation of glycogen biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of macroautophagy|negative regulation of macroautophagy	protein kinase activity|cyclin-dependent protein kinase activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YLR025W	SNF7	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT	0.0231456136594246	0.180073599846694	720	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes	cellular response to anoxia|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	protein binding	ESCRT III complex|cytoplasm
YKR097W	PCK1	hom	FT	CARBOHYDRATE METABOLISM	0.0231307367879318	0.18035376165658	721	Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol	gluconeogenesis	phosphoenolpyruvate carboxykinase (ATP) activity	cytosol
YFR041C	ERJ5	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0231260361003739	0.180702479145843	722	Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response	protein folding	molecular_function	endoplasmic reticulum
YPR196W_p	YPR196W	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0230794365530286	0.181322331915909	723	Putative maltose-responsive transcription factor	regulation of transcription, DNA-dependent	sequence-specific DNA binding	cellular_component
YBR180W	DTR1	hom	FT	CELL WALL ORG/BIOGENESIS	0.0230507098845048	0.181866386369903	724	Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation	ascospore wall assembly|amine transport|transmembrane transport	amine transmembrane transporter activity	integral to membrane|prospore membrane
YGR156W	PTI1	het	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.0230250967704065	0.182352493192396	725	Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64	termination of RNA polymerase II transcription, exosome-dependent|mRNA cleavage|termination of RNA polymerase II transcription, poly(A)-coupled|mRNA polyadenylation|snoRNA 3'-end processing	RNA binding	mRNA cleavage and polyadenylation specificity factor complex|nucleus
YLR188W	MDL1	hom	FT	NUCLEOTIDE METABOLISM|MITOCHONDRION	0.0230049582212129	0.182735374994807	726	Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress	oligopeptide transport|oligopeptide export from mitochondrion	ATPase activity|oligopeptide-transporting ATPase activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YML093W	UTP14	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0229958323638474	0.183235741981804	727	Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus
YPR168W	NUT2	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0229840173425022	0.183134142419019	728	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	molecular_function	core mediator complex
YNL151C	RPC31	het	FT	NUCLEUS	0.0229679158911903	0.183833641147485	729	RNA polymerase III subunit C31	transcription initiation from RNA polymerase III promoter|tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YIL068C	SEC6	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH	0.0229649418232172	0.183563296365621	730	Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p	exocyst localization|Golgi to plasma membrane transport|exocytosis|vesicle fusion|negative regulation of SNARE complex assembly|vesicle docking involved in exocytosis	protein homodimerization activity	mating projection tip|cellular bud neck|cellular bud tip|exocyst
YLR443W	ECM7	hom	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS	0.0229646445293468	0.183503623543275	731	Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency	fungal-type cell wall organization|calcium ion transport	molecular_function	integral to membrane
YCL043C	PDI1	het	FT	ENDOPLASMIC RETICULUM	0.0229625215892673	0.1835441461014	732	Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication	protein folding	protein disulfide oxidoreductase activity|protein disulfide isomerase activity	endoplasmic reticulum lumen
YBR015C	MNN2	hom	FF|FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0229563980533423	0.183661068922849	733	Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment	protein glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YBL008W	HIR1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.0229505389623701	0.184100156530401	734	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores	DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter	nucleosome binding|transcription corepressor activity|DNA binding	chromosome, centromeric region|HIR complex|nucleus
YCR095C_p	OCA4	hom			0.0229304197991811	0.184157711075301	735	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts	biological_process	molecular_function	cytoplasm
YJL139C	YUR1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.022930066533955	0.184164471505228	736	Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication	cell wall mannoprotein biosynthetic process|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YNL198C_d	YNL198C	hom			0.0229213353723735	0.184331617949666	737	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL143C	RIB4	hom	FT	NUCLEUS	0.0228962296400804	0.184878355847345	738	Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin	riboflavin biosynthetic process	6,7-dimethyl-8-ribityllumazine synthase activity	nucleus|cytoplasm
YER116C	SLX8	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0228891217586406	0.184949275723324	739	Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress	protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination	ubiquitin-protein ligase activity	ubiquitin ligase complex|nucleus
YGL207W	SPT16	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0228801890399584	0.185120820748983	740	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome	DNA replication-independent nucleosome organization|regulation of transcription by chromatin organization|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription initiation from RNA polymerase II promoter|nucleosome assembly|transcription elongation from RNA polymerase II promoter|DNA-dependent DNA replication	chromatin binding|nucleosome binding|histone binding	nuclear chromatin|FACT complex|replication fork protection complex|alpha DNA polymerase:primase complex|transcription elongation factor complex
YKL075C_p	YKL075C	hom			0.0228718141273373	0.18528176043509	741	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin	response to drug	molecular_function	cytoplasm
YER184C_p	YER184C	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0228437239403516	0.18588793179999	742	Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source	biological_process	sequence-specific DNA binding	cellular_component
YFL048C	EMP47	hom	FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.0228389034940442	0.185915202124802	743	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport	ER to Golgi vesicle-mediated transport	glycoprotein binding	fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YGR079W_p	YGR079W	hom			0.0227950693633339	0.186761375101386	744	Putative protein of unknown function; YGR079W is not an essential gene	biological_process	molecular_function	cellular_component
YNL257C	SIP3	hom	FT	TRANSCRIPTION FROM RNA POL II	0.0227732595328573	0.187183449463942	745	Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	transcription cofactor activity	integral to membrane
YDR010C_d	YDR010C	hom			0.0227527412061756	0.188306509191802	746	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL161C	KDX1	hom	FT	PROTEIN PHOSPHORYLATION	0.0227325823087585	0.188236088637939	747	Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p	biological_process	protein kinase activity	cellular_component
YIL037C	PRM2	hom			0.0227020378723141	0.188566668790986	748	Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion	karyogamy involved in conjugation with cellular fusion	molecular_function	integral to membrane
YHL036W	MUP3	hom			0.0226999460451208	0.188937263207579	749	Low affinity methionine permease, similar to Mup1p	amino acid transport	L-methionine transmembrane transporter activity	integral to membrane|membrane
YJL022W_d	YJL022W	hom			0.0226947383125212	0.18870886057162	750	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130	Unknown	Unknown	Unknown
YLL039C	UBI4	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0226931054335694	0.188740679053242	751	Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress	protein deubiquitination|ascospore formation|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress	ATP-dependent protein binding|protein tag	cytoplasm
YGL120C	PRP43	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION	0.0226577760951953	0.189430079628601	752	RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|spliceosomal complex disassembly|ribosomal large subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA|rRNA processing	ATP-dependent RNA helicase activity	mitochondrion|post-mRNA release spliceosomal complex|90S preribosome
YNL097C-B_p	YNL097C-B	hom			0.0226380014094542	0.189882810394137	753	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR247W	SRL1	hom	FT	CELL WALL ORG/BIOGENESIS|SITE OF POLARIZED GROWTH	0.0226283034055625	0.1900066140344	754	Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication	fungal-type cell wall organization|nucleobase-containing compound metabolic process	molecular_function	fungal-type cell wall|fungal-type vacuole|cytoplasm|cellular bud tip
YHR107C	CDC12	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.022554285462368	0.192123649962584	755	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells	maintenance of cell polarity|cell cycle cytokinesis|positive regulation of protein kinase activity|septin ring assembly	protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding	septin filament array|cellular bud neck septin ring|septin complex|cytoplasm|mating projection
YER156C_p	YER156C	hom	FT	NUCLEUS	0.0225221722874865	0.192093416663241	756	Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1	biological_process	molecular_function	nucleus|cytoplasm
YML013W	UBX2	hom	FF|FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|UBIQUITIN LIGASE COMPLEX	0.0225173178105338	0.19218926906457	757	Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis	proteasomal ubiquitin-dependent protein catabolic process|ER-associated protein catabolic process|lipid particle organization	protein binding, bridging	mitochondrial outer membrane|Doa10p ubiquitin ligase complex|integral to endoplasmic reticulum membrane|lipid particle|endoplasmic reticulum
YJR134C	SGM1	hom	FT	GOLGI APPARATUS	0.0225159635487333	0.192216015443758	758	Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus	biological_process	molecular_function	COPI-coated vesicle|Golgi apparatus
YBR160W	CDC28	het	FT	CELL CYCLE|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0225107863863193	0.192318288504144	759	Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress	regulation of budding cell apical bud growth|negative regulation of meiotic cell cycle|positive regulation of triglyceride catabolic process|protein phosphorylation|regulation of filamentous growth|negative regulation of transcription, DNA-dependent|positive regulation of meiotic cell cycle|positive regulation of transcription, DNA-dependent|regulation of double-strand break repair via homologous recombination|vesicle-mediated transport|positive regulation of DNA replication involved in S phase|positive regulation of mitotic cell cycle|positive regulation of spindle pole body separation|chromatin remodeling|negative regulation of mitotic cell cycle	histone binding|protein kinase activity|cyclin-dependent protein kinase activity	cyclin-dependent protein kinase holoenzyme complex|ribosome|endoplasmic reticulum|nucleus|spindle pole body|cellular bud neck|astral microtubule|cytoplasm
YER165W	PAB1	het	FF|FT	RNA PROCESSING|TRANSLATION|RNA LOCALIZATION|NUCLEUS|RIBOSOME	0.0225103569698318	0.192326773274495	760	Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G	regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	poly(A) RNA binding	ribosome|nucleus|cytoplasmic stress granule|cytoplasm
YGR232W	NAS6	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS	0.0225001846455237	0.193258992829861	761	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6	proteolysis|proteasome regulatory particle assembly	molecular_function	cytosol|nucleus|proteasome regulatory particle
YMR172C-A_d	YMR172C-A	hom			0.0224971300066357	0.192920226536273	762	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR203C	MSS51	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.022444948668095	0.193622379225561	763	Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	extrinsic to mitochondrial inner membrane|mitochondrion
YLR376C	PSY3	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0224378986934869	0.193762406477744	764	Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C	recombinational repair|error-free translesion synthesis	molecular_function	nucleus|Shu complex|cytoplasm
YJL066C	MPM1	hom	FT	MITOCHONDRION	0.0223989685421	0.19453697925189	765	Mitochondrial intermembrane space protein of unknown function	biological_process	molecular_function	mitochondrion|extrinsic to membrane
YDR014W	RAD61	hom	FT	CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.022368484112256	0.195145095457602	766	Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin	mitotic sister chromatid cohesion	molecular_function	nuclear cohesin complex
YAL036C	RBG1	hom	FT	TRANSLATION|RIBOSOME	0.0223456202231098	0.195602107548158	767	Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid	cytoplasmic translation	GTP binding	polysomal ribosome|polysome|cytoplasm
YAR035C-A_p	YAR035C-A	hom			0.0223337800696913	0.195839081006546	768	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YPL203W	TPK2	hom	FT	SIGNALING|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0223055226484711	0.196405485866276	769	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase	protein phosphorylation|Ras protein signal transduction|invasive growth in response to glucose limitation	cAMP-dependent protein kinase activity|protein kinase activity	nucleus|cAMP-dependent protein kinase complex
YOR097C_p	YOR097C	hom			0.0222721475448469	0.197142811619764	770	Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene	biological_process	molecular_function	cellular_component
YGR243W	FMP43	hom	FT	MITOCHONDRION	0.0222299665132162	0.197925857669109	771	Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|mitochondrial membrane
YBL100W-C_p	YBL100W-C	hom			0.022195765360765	0.198951889915782	772	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YDR197W	CBS2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0221922427489827	0.198688164049471	773	Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader	mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial ribosome
YGR144W	THI4	hom	FT	MITOCHONDRION ORGANIZATION|NUCLEUS	0.0221790699039765	0.198954860258746	774	Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents	thiamine biosynthetic process|mitochondrial genome maintenance|thiazole biosynthetic process	ferrous iron binding	cytosol
YOR039W	CKB2	hom	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0221755074980002	0.19936222822795	775	Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase	regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase inhibitor activity|protein kinase regulator activity	protein kinase CK2 complex|UTP-C complex|CURI complex
YML078W	CPR3	hom	FT	MITOCHONDRION	0.0221687870253925	0.199163228164013	776	Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria	protein folding|apoptotic process	peptidyl-prolyl cis-trans isomerase activity	mitochondrion
YDR256C	CTA1	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.02215051288209	0.199533920953805	777	Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation	response to reactive oxygen species|age-dependent response to reactive oxygen species|hydrogen peroxide catabolic process	catalase activity	peroxisomal matrix|mitochondrial matrix
YGR040W	KSS1	hom	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0221251437183468	0.200049371756316	778	Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains	pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|negative regulation of sequence-specific DNA binding transcription factor activity|protein phosphorylation|invasive growth in response to glucose limitation	MAP kinase activity|protein kinase activity|transcription factor binding	nucleus
YDR469W	SDC1	hom	FT	CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS	0.0221180522349526	0.200193630205434	779	Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30	histone H3-K4 methylation|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YNL317W	PFS2	het	FT	RNA PROCESSING|NUCLEUS	0.0220872969972161	0.201156204592615	780	Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex	mRNA cleavage|mRNA polyadenylation	RNA binding	mRNA cleavage and polyadenylation specificity factor complex
YOR339C	UBC11	hom			0.0220682402770833	0.201209069538318	781	Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2	protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YFL044C	OTU1	hom	FT	PROTEOLYSIS|NUCLEUS	0.0220332879945565	0.201991089100499	782	Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress	protein deubiquitination|regulation of transcription, DNA-dependent	ubiquitin-specific protease activity	nucleus|cytoplasm
YMR144W_p	YMR144W	hom	FT	NUCLEUS	0.0220234929509506	0.202124461660236	783	Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene	biological_process	molecular_function	nucleus
YDR407C	TRS120	het	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|GOLGI APPARATUS	0.0219952341734746	0.202704109883985	784	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic	regulation of Rab GTPase activity|early endosome to Golgi transport|intra-Golgi vesicle-mediated transport	Rab guanyl-nucleotide exchange factor activity	trans-Golgi network|TRAPP complex|early endosome
YIL094C	LYS12	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.0219916776129711	0.202777148251789	785	Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate	lysine biosynthetic process	homoisocitrate dehydrogenase activity	mitochondrion
YPL108W_p	YPL108W	hom			0.0219855375144833	0.202970641817873	786	Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cytoplasm
YDL082W	RPL13A	hom	FT	TRANSLATION|RIBOSOME	0.0219764574346953	0.203089929908237	787	Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YMR176W	ECM5	hom	FT	CELL WALL ORG/BIOGENESIS|NUCLEUS|CHROMOSOME	0.0219238914465892	0.204172885989437	788	Non-essential protein of unknown function; contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress	fungal-type cell wall organization	molecular_function	nucleus|Snt2C complex
YOR265W	RBL2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0218808436035126	0.205062873822331	789	Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress	tubulin complex assembly|tubulin complex biogenesis	tubulin binding|beta-tubulin binding	cytoplasm
YHR177W_p	YHR177W	hom			0.0218756588458272	0.205170255442195	790	Putative protein of unknown function; overexpression causes a cell cycle delay or arrest	biological_process	molecular_function	cellular_component
YNL247W	YNL247W	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.0218652293634805	0.205386384405299	791	Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments	cysteinyl-tRNA aminoacylation	cysteine-tRNA ligase activity	ribosome|cytoplasm
YOL152W	FRE7	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|PLASMA MEMBRANE	0.021860731191665	0.205479650536038	792	Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YOL097C	WRS1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.0218440533384567	0.205825721483477	793	Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA	tryptophanyl-tRNA aminoacylation	tryptophan-tRNA ligase activity	cytoplasm
YMR100W	MUB1	hom	FT	CELL DIVISION	0.0218408665558246	0.20623028889049	794	MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene	regulation of cell budding|protein monoubiquitination	molecular_function	cellular_component
YDR379C-A	YDR379C-A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0218392399961945	0.205925678582847	795	Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy	mitochondrial respiratory chain complex II assembly	molecular_function	mitochondrion
YOR248W_d	YOR248W	hom			0.0218344181882666	0.206025846822993	796	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR082C	KSP1	hom	FT	PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0218298456203674	0.206120870028002	797	Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress	TOR signaling cascade|protein phosphorylation|Unknown|cellular protein localization|regulation of filamentous growth|negative regulation of macroautophagy	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YMR062C	ARG7	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|MITOCHONDRION	0.0218283833868694	0.206218912816874	798	Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine	fungal-type cell wall organization|ornithine biosynthetic process|arginine biosynthetic process	acetyl-CoA:L-glutamate N-acetyltransferase activity|glutamate N-acetyltransferase activity	mitochondrion|mitochondrial matrix
YLR096W	KIN2	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION|PLASMA MEMBRANE	0.0218046793620212	0.206644423243811	799	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p	protein autophosphorylation|exocytosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	plasma membrane
YDL084W	SUB2	het	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0218044152202769	0.206649923502505	800	Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress	mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|mRNA splicing, via spliceosome|transcription elongation from RNA polymerase II promoter|chromatin silencing at telomere	ATP-dependent RNA helicase activity	chromosome, telomeric region|nucleus|transcription export complex|spliceosomal complex
YPR047W	MSF1	hom	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0217705119433655	0.207356778138185	801	Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase	phenylalanyl-tRNA aminoacylation|mitochondrial phenylalanyl-tRNA aminoacylation	phenylalanine-tRNA ligase activity	mitochondrion
YMR269W	TMA23	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0217436798009197	0.207917447382281	802	Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan	ribosomal small subunit biogenesis	molecular_function	ribosome|nucleolus
YBR017C	KAP104	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|SITE OF POLARIZED GROWTH	0.0217388089028042	0.208019344646259	803	Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis	protein import into nucleus|cell cycle|mRNA-binding (hnRNP) protein import into nucleus|transcription factor import into nucleus	nuclear localization sequence binding	cytosol|integral to membrane|cellular bud neck|cellular bud tip
YKL112W	ABF1	het	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS	0.0217380303302962	0.208035635430064	804	DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair	negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	DNA replication origin binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding, bending	nucleotide-excision repair factor 4 complex|nucleus
YGR180C	RNR4	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.0216569034820603	0.210078270894508	805	Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress	cofactor biosynthetic process|deoxyribonucleotide biosynthetic process	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ribonucleoside-diphosphate reductase complex|nucleus|cytoplasm
YGL077C	HNM1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0216464363069129	0.2099585991258	806	Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol	choline transport|ethanolamine transport|glycine betaine transport	choline transmembrane transporter activity|ethanolamine transmembrane transporter activity	integral to membrane|plasma membrane
YJR080C	AIM24	hom	FT	MITOCHONDRION	0.0215956527657491	0.211030296409088	807	Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YPR038W_d	IRC16	hom			0.0215299869321705	0.212421913239805	808	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci	Unknown	Unknown	Unknown
YJR054W	KCH1	hom			0.0215121319066932	0.212801447299573	809	Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YPL168W_p	YPL168W	hom	FT	MITOCHONDRION	0.0215067995591273	0.212914888813778	810	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated	biological_process	molecular_function	mitochondrion
YPL250C	ICY2	hom			0.0214972301712984	0.213118579464979	811	Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate	mitochondrion degradation	molecular_function	cellular_component
YDR479C	PEX29	hom	FT	PEROXISOME ORGANIZATION	0.0214926166388114	0.213216831727938	812	Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress	peroxisome organization	molecular_function	integral to membrane|peroxisomal membrane
YGL161C	YIP5	hom	FT	GOLGI APPARATUS	0.0214897331590114	0.213278256454441	813	Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YDR486C	VPS60	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	0.021473616176944	0.213621820211907	814	Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p	late endosome to vacuole transport via multivesicular body sorting pathway|filamentous growth	molecular_function	fungal-type vacuole membrane|cytoplasm
YLR147C	SMD3	het	FT	RNA PROCESSING|NUCLEUS	0.0214305071600963	0.214953286692412	815	Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3	mRNA splicing, via spliceosome	mRNA binding	commitment complex|U1 snRNP|U2-type prespliceosome|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YLR143W	DPH6	hom			0.0214078233723215	0.215028457957438	816	Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene	biological_process	molecular_function	cytoplasm
YMR026C	PEX12	hom	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	0.021403005679534	0.215679713451557	817	C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder	protein import into peroxisome matrix	ubiquitin-protein ligase activity|protein binding	integral to peroxisomal membrane
YDR303C	RSC3	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS|RSC COMPLEX	0.0213927654358689	0.217346233128074	818	Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p	nucleosome positioning|ATP-dependent chromatin remodeling|regulation of cell cycle|nucleosome disassembly|regulation of DNA replication involved in S phase|regulation of transcription, DNA-dependent|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	sequence-specific DNA binding|DNA translocase activity|DNA binding	RSC complex|nucleus
YDL049C	KNH1	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	0.0213842328210671	0.215602881522945	819	Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance	(1->6)-beta-D-glucan biosynthetic process	molecular_function	fungal-type cell wall|extracellular region
YMR183C	SSO2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.0213444403850287	0.216389872517016	820	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p	Golgi to plasma membrane transport|ascospore-type prospore assembly|vesicle fusion	phosphatidic acid binding|SNAP receptor activity	endoplasmic reticulum|plasma membrane|prospore membrane|cytoplasm
YBL103C	RTG3	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|SIGNALING|NUCLEUS	0.0213425349888918	0.21643089466159	821	Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways	mitochondrion degradation|cellular response to oleic acid|mitochondria-nucleus signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription factor import into nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus|cytoplasm
YPL247C_p	YPL247C	hom	FT	NUCLEUS	0.0213278312506356	0.216816182701524	822	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest	biological_process	molecular_function	nucleus|cytoplasm
YDR291W	HRQ1	hom	FT	NUCLEUS	0.0213097290134313	0.218652518417089	823	3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)	biological_process	molecular_function	nucleus
YKR062W	TFA2	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0212682314751557	0.218378414573218	824	TFIIE small subunit, involved in RNA polymerase II transcription initiation	transcription from RNA polymerase II promoter	single-stranded DNA binding|RNA polymerase II core binding|TFIIH-class transcription factor binding	transcription factor TFIIE complex
YGL075C	MPS2	het	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON	0.0212527497495706	0.218370269923594	825	Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p	mitotic anaphase|spindle pole body duplication associated with nuclear envelope	structural constituent of cytoskeleton	nuclear envelope|spindle pole body
YDR385W	EFT2	hom	FT	TRANSLATION|NUCLEOTIDE METABOLISM|RIBOSOME	0.0212481562722723	0.218469824294973	826	Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication	translational elongation|positive regulation of translational elongation	translation elongation factor activity	ribosome
YMR301C	ATM1	het	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION	0.0212424186150359	0.218662901625482	827	Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol	cellular iron ion homeostasis	ATPase activity, coupled to transmembrane movement of substances|ATPase activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDR090C_p	YDR090C	hom	FT	PLASMA MEMBRANE	0.0212370311794146	0.218711073340191	828	Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YLR440C	SEC39	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0212317901738447	0.218824791466417	829	Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope	retrograde vesicle-mediated transport, Golgi to ER|vesicle-mediated transport|ER-dependent peroxisome organization	molecular_function	Dsl1p complex|nuclear envelope|endoplasmic reticulum|peroxisome|endoplasmic reticulum membrane
YOR192C	THI72	hom			0.0212309281449214	0.21911844785411	830	Transporter of thiamine or related compound; shares sequence similarity with Thi7p	thiamine transport	transporter activity	integral to membrane|membrane
YML038C	YMD8	hom	FT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0211982590563767	0.219553346553645	831	Putative nucleotide sugar transporter, has similarity to Vrg4p	UDP-glucose transport|nucleotide-sugar transport	nucleotide-sugar transmembrane transporter activity	COPI-coated vesicle|integral to membrane
YKL110C	KTI12	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.0211949040346973	0.219832689984903	832	Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p	regulation of transcription from RNA polymerase II promoter|cell growth|tRNA wobble uridine modification	chromatin binding	nucleus|cytoplasm
YDR346C	SVF1	hom	FT	RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0211729432867254	0.220104552604677	833	Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance	cellular response to oxidative stress	molecular_function	nucleus|cytoplasm
YNL324W_d	YNL324W	hom			0.0211465888258185	0.22067942788307	834	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL173C	MDG1	hom	FT	SIGNALING|PLASMA MEMBRANE	0.0211402004395042	0.220818940978084	835	Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations	pheromone-dependent signal transduction involved in conjugation with cellular fusion	molecular_function	membrane raft|plasma membrane
YPL148C	PPT2	hom	FF|FT	KETONE METABOLISM|LIPID METABOLISM|MITOCHONDRION	0.0211247653897436	0.221156280918923	836	Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation	protein-cofactor linkage	holo-[acyl-carrier-protein] synthase activity	mitochondrion
YER020W	GPA2	hom	FT	SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE	0.0209962917026048	0.223978464094188	837	Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	adenylate cyclase-activating G-protein coupled receptor signaling pathway|ascospore formation|replicative cell aging|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|regulation of cell size	GTPase activity	mitochondrion|plasma membrane
YOR295W	UAF30	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS	0.0209757162716803	0.224640231377189	838	Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|chromatin organization	RNA polymerase I upstream control element sequence-specific DNA binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity	nucleolus|RNA polymerase I upstream activating factor complex
YBL011W	SCT1	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0209664625326046	0.22463738749276	839	Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed	phospholipid biosynthetic process	glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YER188W_d	YER188W	hom			0.0209520256747077	0.22495679299143	840	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p	Unknown	Unknown	Unknown
YMR065W	KAR5	hom	FT	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.020910199402286	0.225884000734245	841	Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone	karyogamy involved in conjugation with cellular fusion	molecular_function	mitochondrion|endoplasmic reticulum membrane
YJL052W	TDH1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0208924564402517	0.226416654112028	842	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress	gluconeogenesis|glycolysis	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YLR225C_p	YLR225C	hom	FT	RESPONSE TO OXIDATIVE STRESS	0.0208438281458345	0.22736091406453	843	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene	biological_process	molecular_function	cytoplasm
YHR125W_d	YHR125W	hom			0.0208341879399156	0.227576001814035	844	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR271W	SLH1	hom	FT	TRANSLATION|RIBOSOME	0.0208085544405554	0.228148629476751	845	Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses	cytoplasmic translation|regulation of translation	RNA helicase activity	polysomal ribosome|cytoplasm
YHR050W-A_p	YHR050W-A	hom			0.0207927219435492	0.22850282431107	846	Protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YOL127W	RPL25	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.020786467027818	0.228642863224386	847	Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YGL034C_d	YGL034C	hom			0.0207770339590412	0.228854172092637	848	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR075W	UFE1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0207701129176317	0.229009297740895	849	t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER	retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum membrane fusion|vesicle fusion with endoplasmic reticulum	SNAP receptor activity	SNARE complex|integral to membrane|endoplasmic reticulum
YPR020W	ATP20	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.0207234640426174	0.230056819928767	850	Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex	protein oligomerization|cristae formation|protein complex assembly|ATP synthesis coupled proton transport	structural molecule activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YKR053C	YSR3	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0207228005990779	0.230071742385754	851	Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication	phospholipid dephosphorylation|sphingolipid biosynthetic process	sphingosine-1-phosphate phosphatase activity	integral to membrane|endoplasmic reticulum
YLR255C_d	YLR255C	hom			0.020718081553386	0.230177905039947	852	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL283C	WSC2	hom	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.020697822094424	0.230634070303789	853	Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response	fungal-type cell wall organization|response to heat|Rho protein signal transduction	transmembrane signaling receptor activity	site of polarized growth|cellular bud|mating projection tip|cytoplasm
YER038W-A_d	YER038W-A	hom			0.0206735443731476	0.231599338394981	854	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria	Unknown	Unknown	Unknown
YHL033C	RPL8A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.020626423049641	0.232246822007662	855	Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR431W_d	YDR431W	hom			0.0205503450368829	0.234253175144412	856	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL190C	RPS22A	hom	FT	TRANSLATION|RIBOSOME	0.0205184150027398	0.234701671460671	857	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YLL018C-A	COX19	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.0205040086892524	0.235100296141492	858	Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex IV assembly|metal ion transport	copper ion binding|copper chaperone activity	cytosol|mitochondrial intermembrane space
YJL004C	SYS1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0205013431613589	0.23537076365848	859	Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation	vesicle organization|Golgi to plasma membrane protein transport|Golgi to endosome transport	molecular_function	trans-Golgi network|integral to membrane|integral to Golgi membrane
YGR168C_p	YGR168C	hom			0.020489246564533	0.235367761901614	860	Putative protein of unknown function; YGR168C is not an essential gene	biological_process	molecular_function	integral to membrane
YDL053C	PBP4	hom	FT	NUCLEUS	0.0204883320451444	0.235388667466731	861	Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasmic stress granule|cytoplasm
YER104W	RTT105	het	FT	NUCLEUS	0.0204699529772245	0.235809084467985	862	Protein with a role in regulation of Ty1 transposition	negative regulation of transposition, RNA-mediated	molecular_function	nucleus|cytoplasm
YGR265W_d	YGR265W	het			0.020457495460747	0.236094349101727	863	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase	Unknown	Unknown	Unknown
YIR031C	DAL7	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	0.0204282954374767	0.237113775144498	864	Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process	malate synthase activity	cellular_component
YOL112W	MSB4	hom	FT	SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH	0.0203857335552051	0.237742375764391	865	GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization	actin filament organization	Rab GTPase activator activity	incipient cellular bud site|polarisome|cellular bud tip
YHR200W	RPN10	hom	FT	PROTEOLYSIS	0.020361172109205	0.238308295437794	866	Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein	ubiquitin-dependent protein catabolic process	structural molecule activity|polyubiquitin binding	proteasome complex|proteasome regulatory particle, base subcomplex
YMR044W	IOC4	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS	0.0203535357346924	0.238834762628007	867	Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing	chromatin remodeling	nucleosome binding|ATPase activity|DNA binding	ISW1 complex
YER031C	YPT31	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS	0.0203399169174353	0.238868835550003	868	Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication	early endosome to Golgi transport|vesicle-mediated transport|exocytosis	GTPase activity	mitochondrial outer membrane|endosome|Golgi apparatus
YDL073W_p	YDL073W	hom			0.0203393439024552	0.239022212222285	869	Putative protein of unknown function; YDL073W is not an essential gene	biological_process	molecular_function	cellular_component
YPR105C	COG4	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.020338571635883	0.238829871510615	870	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	peroxisome degradation|intra-Golgi vesicle-mediated transport|retrograde transport, vesicle recycling within Golgi|macroautophagy|CVT pathway	molecular_function	Golgi transport complex
YHR155W	YSP1	hom	FF|FT	MITOCHONDRION	0.0203229441652075	0.239190994403274	871	Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion
YFL039C	ACT1	het	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MEMBRANE ORGANIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPON	0.0202937690099359	0.23986620994368	872	Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions	ascospore wall assembly|vacuole inheritance|protein secretion|DNA repair|budding cell isotropic bud growth|mitochondrion inheritance|fungal-type cell wall organization|vesicle transport along actin filament|establishment of cell polarity|chronological cell aging|cytokinesis|actin filament reorganization involved in cell cycle|histone acetylation|endocytosis|exocytosis|establishment of mitotic spindle orientation|regulation of transcription from RNA polymerase II promoter|actomyosin contractile ring contraction|cellular response to oxidative stress	structural constituent of cytoskeleton	cellular bud neck contractile ring|actin filament|histone acetyltransferase complex|Swr1 complex|actin filament bundle|NuA4 histone acetyltransferase complex|Ino80 complex|actin cortical patch
YPL182C_d	YPL182C	hom			0.0202737067050486	0.240331300750735	873	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W	Unknown	Unknown	Unknown
YOR121C_d	YOR121C	hom			0.0202726326307792	0.240707077188124	874	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W	Unknown	Unknown	Unknown
YDL033C	SLM3	hom	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0202712173336925	0.240810171037556	875	tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)	mitochondrial tRNA thio-modification	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	mitochondrion
YLR321C	SFH1	het	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|RSC COMPLEX	0.0202257152042604	0.241516614083641	876	Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog	ATP-dependent chromatin remodeling|double-strand break repair|chromosome segregation|regulation of DNA replication involved in S phase|chromatin remodeling at centromere|nucleosome disassembly|G2/M transition of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	DNA translocase activity	RSC complex
YCL044C	MGR1	hom	FT	PROTEOLYSIS|MITOCHONDRION	0.0202256414929479	0.242010307371919	877	Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA	misfolded or incompletely synthesized protein catabolic process	misfolded protein binding	mitochondrion|i-AAA complex
YGL062W	PYC1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.0202229103823276	0.241862897863027	878	Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication	NADPH regeneration|gluconeogenesis	pyruvate carboxylase activity	cytosol
YBR279W	PAF1	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING|NUCLEUS|CHROMOSOME|RNA POL II, HOLOENZYME	0.0202138344480642	0.241723053579935	879	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1	negative regulation of DNA recombination|mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of transcription-coupled nucleotide-excision repair|rRNA processing|transcription elongation from RNA polymerase I promoter|regulation of chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin silencing at rDNA|Unknown|snoRNA 3'-end processing|transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity	transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YOR330C	MIP1	hom	FT	MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0202063046600763	0.242249775027523	880	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit	mitochondrial DNA replication	3'-5' exonuclease activity|DNA-directed DNA polymerase activity	mitochondrion
YOR207C	RET1	het	FF|FT	NUCLEUS	0.0201692787022536	0.242762441230913	881	Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YOR165W	SEY1	hom	FT	MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0201580089986774	0.243025835619933	882	Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3	cellular membrane organization|endoplasmic reticulum organization|endoplasmic reticulum membrane fusion|endoplasmic reticulum inheritance	GTPase activity	integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum|cytoplasm
YNL053W	MSG5	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0201474007753875	0.243273953359883	883	Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|regulation of fungal-type cell wall organization|inactivation of MAPK activity involved in cell wall biogenesis|regulation of MAPK export from nucleus|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion	protein tyrosine/serine/threonine phosphatase activity	nucleus|cytoplasm
YDR067C_p	OCA6	hom			0.0201329976062493	0.243611116544001	884	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT	biological_process	molecular_function	cytoplasm
YKL055C	OAR1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0201165402950135	0.243996766585158	885	Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p	fatty acid metabolic process|aerobic respiration	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	mitochondrion
YBR031W	RPL4A	hom	FT	TRANSLATION|RIBOSOME	0.0201083923883935	0.244187857922677	886	Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR212W	TCP1	het			0.0200810138977864	0.244830729965253	887	Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein	protein folding	unfolded protein binding	plasma membrane|chaperonin-containing T-complex
YBR022W	POA1	hom	FT	RNA PROCESSING	0.0200693164601853	0.245105758185222	888	Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing	tRNA splicing, via endonucleolytic cleavage and ligation	phosphatase activity	cellular_component
YLR295C	ATP14	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	0.0200689092006636	0.245115337505338	889	Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress	cristae formation|mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YEL054C	RPL12A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0200610766604393	0.245299621015821	890	Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome	cytosolic large ribosomal subunit
YHR121W	LSM12	hom	FT	NUCLEUS	0.0199908868601757	0.246955378801979	891	Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress	RNA metabolic process	RNA binding	ribosome|nucleus|cytoplasmic stress granule|cytoplasm
YOR180C	DCI1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	0.0199369294995308	0.24823352637035	892	Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed	fatty acid beta-oxidation	dodecenoyl-CoA delta-isomerase activity	peroxisomal matrix
YER119C-A_d	YER119C-A	hom	FF		0.0199153503647965	0.248745987957373	893	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2	Unknown	Unknown	Unknown
YMR194W	RPL36A	hom	FT	TRANSLATION|RIBOSOME	0.0198714095162516	0.249791780744685	894	Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YGR208W	SER2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.019820861085522	0.251281468842636	895	Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source	L-serine biosynthetic process	phosphoserine phosphatase activity	nucleus|cytoplasm
YJR010C-A	SPC1	hom	FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0198187750411881	0.251048518823144	896	Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress	signal peptide processing|protein targeting to ER	molecular_function	signal peptidase complex
YBL005W	PDR3	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0198115007700535	0.25122255076525	897	Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YNL329C	PEX6	hom	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION	0.019810424923971	0.251248296784659	898	AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol	protein import into peroxisome matrix, receptor recycling|replicative cell aging	ATPase activity|protein heterodimerization activity	cytosol|peroxisome
YNL264C	PDR17	hom	FT	LIPID METABOLISM	0.0197856246278882	0.251842301625486	899	Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition	Golgi to plasma membrane protein transport|phosphatidylserine metabolic process|response to drug|sterol biosynthetic process|Unknown|phospholipid transport|phospholipid biosynthetic process	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	endosome|cell periphery|cytosol|cytoplasm
YIL032C_d	YIL032C	hom			0.0197591461374617	0.25261909166397	900	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIR009W	MSL1	hom	FT	RNA PROCESSING|NUCLEUS	0.0197398912734594	0.252940250513038	901	U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members	mRNA splicing, via spliceosome	U2 snRNA binding	U2 snRNP|U2-type prespliceosome
YLR291C	GCD7	het	FT	TRANSLATION|MITOCHONDRION	0.0196842859407079	0.254279686520755	902	Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression	regulation of translational initiation	enzyme regulator activity|translation initiation factor activity|guanyl-nucleotide exchange factor activity	mitochondrion|eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YDR123C	INO2	hom	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|NUCLEUS	0.0196308670975366	0.255571092280377	903	Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion	phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YBR111W-A	SUS1	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE|HISTONE ACETYLTRANSFERASE	0.0196092052273446	0.256521856478804	904	Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP	poly(A)+ mRNA export from nucleus|regulation of protein localization|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone deubiquitination|histone H3-K4 methylation|transcription elongation from RNA polymerase II promoter|histone H3-K79 methylation|positive regulation of transcription from RNA polymerase II promoter	enzyme activator activity	DUBm complex|nucleoplasm|transcription export complex 2|SAGA complex|nuclear pore
YMR234W	RNH1	hom	FT	CELL WALL ORG/BIOGENESIS|NUCLEUS	0.0195992549972191	0.256337460276733	905	Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)	fungal-type cell wall organization|RNA catabolic process	ribonuclease H activity	intracellular|nucleus
YLR436C	ECM30	hom	FT	CELL WALL ORG/BIOGENESIS	0.0195887495780107	0.256592494589858	906	Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm	fungal-type cell wall organization	molecular_function	cytoplasm
YDR450W	RPS18A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|MITOCHONDRION|RIBOSOME	0.019581962075593	0.256757364688281	907	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit|mitochondrion
YDR484W	VPS52	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|GOLGI APPARATUS|CYTOSKELETON	0.0195401663863991	0.257987212013795	908	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin	actin filament-based process|Golgi to vacuole transport|retrograde transport, endosome to Golgi	protein binding	Golgi apparatus|GARP complex
YIL009C-A	EST3	hom	FT	NUCLEUS|CHROMOSOME	0.0194573202042245	0.259798020873731	909	Component of the telomerase holoenzyme, involved in telomere replication	telomere maintenance via telomerase	ATP-dependent DNA/RNA helicase activity|GTPase activity|telomeric DNA binding	chromosome, telomeric region|nucleus|telomerase holoenzyme complex
YOL100W	PKH2	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0194544012503042	0.259869526535868	910	Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p	regulation of nuclear-transcribed mRNA poly(A) tail shortening|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly	protein kinase activity	cell cortex|eisosome|nucleus
YNL319W_d	YNL319W	hom			0.0194089539744726	0.260984606091993	911	Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14	Unknown	Unknown	Unknown
YDR323C	PEP7	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	0.0193781790314503	0.261741565626246	912	Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance	Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol-3-phosphate binding	external side of endosome membrane|cytoplasm
YDR495C	VPS3	hom	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	0.0193668201664638	0.2620213381095	913	Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase	vacuole inheritance|vacuolar acidification|protein targeting to vacuole	molecular_function	CORVET complex|cytoplasm
YAL047C	SPC72	hom	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CYTOSKELETON	0.0193238913673903	0.263080552997188	914	Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization	microtubule nucleation|nuclear migration along microtubule|mitotic cell cycle spindle orientation checkpoint|mitotic spindle elongation|mitotic sister chromatid segregation	structural constituent of cytoskeleton	outer plaque of spindle pole body
YPL022W	RAD1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS	0.01925944927124	0.264676121263621	915	Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein	mitotic recombination|meiotic mismatch repair|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair via single-strand annealing, removal of nonhomologous ends|removal of nonhomologous ends	single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity	nucleotide-excision repair factor 1 complex|nucleus
YJL129C	TRK1	hom	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.0192574355639095	0.264726087280921	916	Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication	cellular potassium ion homeostasis	potassium ion transmembrane transporter activity	membrane raft|integral to membrane|plasma membrane
YDR194W-A_p	YDR194W-A	hom			0.0192407905191545	0.265495898769085	917	Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YHR163W	SOL3	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0192332090155059	0.267404243327763	918	6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	6-phosphogluconolactonase activity	nucleus|cytoplasm
YIL101C	XBP1	hom	FT	NUCLEUS	0.019230036740615	0.26540657861563	919	Transcriptional repressor; binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress	response to stress	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YLR187W	SKG3	hom	FT	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0192195576617573	0.265667160536507	920	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication	biological_process	molecular_function	cellular bud|cellular bud neck|cytoplasm
YMR009W	ADI1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS	0.0191951887010544	0.266273821129433	921	Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions	L-methionine salvage from methylthioadenosine	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	nucleus|cytoplasm
YDL111C	RRP42	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0191904833135529	0.266391070531682	922	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)	nuclear polyadenylation-dependent tRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nonfunctional rRNA decay|nuclear polyadenylation-dependent mRNA catabolic process|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing	molecular_function	nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YOR109W	INP53	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|CYTOSKELETON	0.019179104960631	0.266674744425795	923	Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity	membrane|actin cortical patch|cytoplasm
YBR002C	RER2	het	FF|FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0191690207838787	0.267283191640697	924	Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting	dolichol biosynthetic process|protein glycosylation|ER to Golgi vesicle-mediated transport	dehydrodolichyl diphosphate synthase activity|prenyltransferase activity	endoplasmic reticulum
YKR055W	RHO4	hom	FT	SIGNALING|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0190795099564584	0.26916661589718	925	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity	positive regulation of formin-nucleated actin cable assembly|maintenance of cell polarity|regulation of formin-nucleated actin cable assembly	GTPase activity	incipient cellular bud site|plasma membrane|cellular bud neck
YBR298C	MAL31	hom	FT	CARBOHYDRATE METABOLISM	0.0190762149029304	0.269821224016196	926	Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C	alpha-glucoside transport|transmembrane transport	alpha-glucoside:hydrogen symporter activity	integral to membrane|membrane
YCL063W	VAC17	hom			0.01907440132725	0.269294863347143	927	Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p	vacuole inheritance	protein anchor	fungal-type vacuole membrane
YPR109W_p	YPR109W	hom	FT	CELL CYCLE	0.0190580838796924	0.269704778644383	928	Predicted membrane protein; dipoid deletion strain has high budding index	biological_process	molecular_function	cellular_component
YPL197C_d	YPL197C	hom			0.0190499033536129	0.270339351963618	929	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B	Unknown	Unknown	Unknown
YJR065C	ARP3	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.019037358540582	0.270226042437666	930	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity	mitochondrion inheritance|Arp2/3 complex-mediated actin nucleation|actin filament organization	ATP binding	Arp2/3 protein complex|plasma membrane
YMR273C	ZDS1	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL WALL ORG/BIOGENESIS|RNA LOCALIZATION|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|SITE OF POLARIZED GROWTH|NUCLEAR PORE	0.0190221412695374	0.270609211959455	931	Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication	mRNA export from nucleus|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|chromatin silencing|establishment of cell polarity|regulation of protein localization|cell aging	protein phosphatase type 2A regulator activity	incipient cellular bud site|nuclear pore|cellular bud neck|cellular bud tip|cytoplasm
YLR058C	SHM2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|SITE OF POLARIZED GROWTH	0.0190006420632148	0.271294147830759	932	Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis	one-carbon metabolic process	glycine hydroxymethyltransferase activity	plasma membrane|mating projection tip|cytoplasm
YDR011W	SNQ2	hom	FF|FT	NUCLEOTIDE METABOLISM|MITOCHONDRION|PLASMA MEMBRANE	0.0189627395846091	0.272108502904718	933	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species	response to drug	xenobiotic-transporting ATPase activity	mitochondrion|integral to membrane|plasma membrane
YGL105W	ARC1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.0189611981676306	0.272147483580437	934	Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress	positive regulation of ligase activity|tRNA aminoacylation for protein translation	enzyme activator activity|tRNA binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding	methionyl glutamyl tRNA synthetase complex|cytoplasm
YPR077C_d	YPR077C	hom			0.0189445226791104	0.272569431892159	935	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1	Unknown	Unknown	Unknown
YIL048W	NEO1	het	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0189352934382211	0.272803156283894	936	Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus	retrograde vesicle-mediated transport, Golgi to ER|vacuole organization|endocytosis	phospholipid-translocating ATPase activity|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	endosome|COPI-coated vesicle|integral to membrane|Golgi apparatus|Golgi membrane
YBL006C	LDB7	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|NUCLEUS|RSC COMPLEX	0.0189284223408152	0.27304877234831	937	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions	ATP-dependent chromatin remodeling|cell wall mannoprotein biosynthetic process|nucleosome disassembly|transcription elongation from RNA polymerase II promoter	DNA translocase activity	RSC complex
YHR161C	YAP1801	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON	0.0188879734292206	0.274003656334323	938	Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication	endocytosis	clathrin binding	actin cortical patch
YIR028W	DAL4	hom			0.0188766933851482	0.274290360794102	939	Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process|allantoin transport	allantoin uptake transmembrane transporter activity	integral to membrane|membrane
YDR316W	OMS1	hom	FT	MITOCHONDRION	0.0188714663546994	0.274494849266668	940	Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations	biological_process	S-adenosylmethionine-dependent methyltransferase activity	mitochondrial envelope|mitochondrion
YDL088C	ASM4	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0188358733882516	0.275329592678164	941	FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication	nuclear pore organization|mRNA export from nucleus in response to heat stress|mitotic cell cycle spindle assembly checkpoint	nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding	nuclear pore central transport channel|integral to membrane|nuclear pore
YBR234C	ARC40	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0188214152740791	0.275698323581308	942	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches	mitochondrion inheritance|actin nucleation|actin filament organization	ubiquitin binding	Arp2/3 protein complex
YNL079C	TPM1	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0188037803382329	0.276148529887817	943	Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication	vacuole inheritance|exocytosis|intracellular mRNA localization|filamentous growth|budding cell apical bud growth|mitochondrion inheritance|budding cell isotropic bud growth|actin polymerization or depolymerization|actin filament organization|pseudohyphal growth|vesicle-mediated transport|establishment of cell polarity|actin filament bundle assembly	actin lateral binding	cellular bud neck contractile ring|actin filament bundle
YJR044C	VPS55	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	0.01877004235999	0.277226209162555	944	Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)	late endosome to vacuole transport via multivesicular body sorting pathway	molecular_function	Vps55/Vps68 complex|late endosome|integral to membrane
YKR043C	SHB17	hom	FT	CARBOHYDRATE METABOLISM|NUCLEUS	0.0187403656131909	0.277771598486566	945	Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus	ribose phosphate biosynthetic process	sedoheptulose-bisphosphatase activity	nucleus|cytoplasm
YHR010W	RPL27A	hom	FT	TRANSLATION|RIBOSOME	0.018703677011864	0.278713584236942	946	Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YAL024C	LTE1	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION	0.0187027981147284	0.279454042731617	947	Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint|vesicle-mediated transport	guanyl-nucleotide exchange factor activity	cellular bud
YAR002W	NUP60	hom	FT	PROTEIN LOCALIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	0.0186876146718053	0.2791266703377	948	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153	double-strand break repair|poly(A)+ mRNA export from nucleus|protein export from nucleus|regulation of protein desumoylation|intracellular mRNA localization|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|chromosome organization|nucleocytoplasmic transport|chromatin silencing at silent mating-type cassette	nucleocytoplasmic transporter activity|phospholipid binding|structural constituent of nuclear pore	nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YDR084C	TVP23	hom	FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0186625712003156	0.279771560217094	949	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|cytoplasm
YER098W	UBP9	hom	FT	PROTEOLYSIS	0.0186550768794087	0.279964741730801	950	Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication	protein deubiquitination	ubiquitin-specific protease activity	cytoplasm
YOR358W	HAP5	hom	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.018607591992761	0.28119086774617	951	Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex
YPR164W	MMS1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0186042898809821	0.281276268156674	952	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay	replication fork processing|negative regulation of transposition, RNA-mediated|recombinational repair|nonfunctional rRNA decay	molecular_function	Cul8-RING ubiquitin ligase complex
YGR223C	HSV2	hom	FT	MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	0.018491194771488	0.284211798402929	953	Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization	piecemeal microautophagy of nucleus	phosphatidylinositol binding	endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YOL159C-A	YOL159C-A	hom	FT	NUCLEUS	0.0184591255420839	0.285479282602423	954	Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	nucleus|cytoplasm
YLR171W_d	YLR171W	hom			0.018443920901359	0.285876351370606	955	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR360W_d	OPI7	hom			0.018343032146855	0.288088812204701	956	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.	Unknown	Unknown	Unknown
YLR406C-A_p	YLR406C-A	hom			0.0183394851741934	0.28818206171709	957	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNR023W	SNF12	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|RSC COMPLEX	0.0183362778243042	0.288626104827454	958	73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive	positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex
YGL137W	SEC27	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0182979440265073	0.289275688152288	959	Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP	retrograde vesicle-mediated transport, Golgi to ER|late endosome to vacuole transport via multivesicular body sorting pathway|ER to Golgi vesicle-mediated transport	ubiquitin binding	COPI vesicle coat
YPL060W	MFM1	hom	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.0182953980183176	0.289342805994166	960	Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p	mitochondrial magnesium ion transport	magnesium ion transmembrane transporter activity	integral to membrane|mitochondrial inner membrane
YNL236W	SIN4	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0182892800927188	0.290152214495551	961	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding	core mediator complex
YCL031C	RRP7	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0182865685442645	0.289575649722864	962	Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress	ribosomal small subunit assembly|rRNA processing	molecular_function	nucleolus|nucleus|UTP-C complex|CURI complex
YOR293W	RPS10A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME	0.0182494502951453	0.290987844440703	963	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YNL116W	DMA2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	0.0182317507829126	0.291024081174488	964	Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains	establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint	ubiquitin-protein ligase activity	cytoplasm
YDL136W	RPL35B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0182196080601776	0.291561501758575	965	Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication	cytoplasmic translation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic large ribosomal subunit|preribosome, large subunit precursor
YDL014W	NOP1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0182073182312883	0.291671220715781	966	Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin	box C/D snoRNA 3'-end processing|rRNA processing|snoRNA processing|rRNA methylation	rRNA methyltransferase activity	small-subunit processome|box C/D snoRNP complex|ribosome|nucleolus|90S preribosome
YDR363W	ESC2	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS	0.0181844565956182	0.292277626600936	967	Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member	intra-S DNA damage checkpoint|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette|mitotic sister chromatid cohesion	molecular_function	nucleus
YLR244C	MAP1	hom	FT	PROTEOLYSIS|RIBOSOME	0.0181710367284025	0.293860586445919	968	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p	negative regulation of gene expression|protein initiator methionine removal involved in protein maturation	metalloaminopeptidase activity|mRNA binding	cytosolic ribosome
YDR281C	PHM6	hom			0.0181565431074982	0.293019180047531	969	Protein of unknown function, expression is regulated by phosphate levels	biological_process	molecular_function	fungal-type vacuole
YGL176C_p	YGL176C	hom			0.0181242121572548	0.29409570601229	970	Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype	biological_process	molecular_function	cellular_component
YGL225W	VRG4	het	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS	0.0181081720262792	0.294523259653646	971	Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi	GDP-mannose transport	GDP-mannose transmembrane transporter activity	mitochondrion|integral to membrane|Golgi apparatus
YDL204W	RTN2	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0179790450214401	0.297764135736487	972	Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication	endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network maintenance	molecular_function	endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YBR081C	SPT7	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION|HISTONE ACETYLTRANSFERASE	0.0179588230149358	0.298307957430244	973	Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex	conjugation with cellular fusion|histone acetylation|protein complex assembly|chromatin modification	structural molecule activity	SLIK (SAGA-like) complex|mitochondrion|SAGA complex
YGL063W	PUS2	hom	FT	RNA PROCESSING|MITOCHONDRION	0.0179522819397803	0.298484005570479	974	Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion
YCR035C	RRP43	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0178921235486889	0.300106374899873	975	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress	nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing	molecular_function	nucleoplasm|nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|cytoplasm
YNL199C	GCR2	hom	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM|NUCLEUS	0.0178422239275444	0.301456533344998	976	Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p	positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity	nuclear envelope|nucleus
YOR255W	OSW1	hom	FT	CELL WALL ORG/BIOGENESIS	0.0178392154410045	0.301538064451623	977	Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p	ascospore wall assembly|ascospore formation	molecular_function	prospore membrane
YDR541C_p	YDR541C	hom	FT	OXIDATION-REDUCTION PROCESS	0.0178363103012313	0.301616808748246	978	Putative dihydrokaempferol 4-reductase	biological_process	carbonyl reductase (NADPH) activity	cellular_component
YHR068W	DYS1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0177826103048001	0.303941509708131	979	Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric	peptidyl-lysine modification to hypusine	transferase activity, transferring alkyl or aryl (other than methyl) groups	cytoplasm
YPL254W	HFI1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0177688968209691	0.303447905228027	980	Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions	histone acetylation|chromatin modification|transcription from RNA polymerase II promoter	transcription coactivator activity|transcription cofactor activity	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YLR006C	SSK1	hom	FT	SIGNALING|PROTEIN PHOSPHORYLATION	0.0177683950896946	0.303461560964495	981	Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate	activation of MAPKKK activity involved in osmosensory signaling pathway|positive regulation of protein autophosphorylation|osmosensory signaling pathway via two-component system	protein kinase activator activity|two-component response regulator activity|protein homodimerization activity|mitogen-activated protein kinase kinase kinase binding	cytoplasm
YDR211W	GCD6	het	FT	TRANSLATION	0.0176986044537485	0.305365046724435	982	Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress	regulation of translational initiation	guanyl-nucleotide exchange factor activity|translation initiation factor activity	eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YJL207C	LAA1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.017674594072541	0.306599361513335	983	AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene	protein localization|retrograde transport, endosome to Golgi	molecular_function	AP-1 adaptor complex|ribosome|clathrin-coated vesicle
YDR060W	MAK21	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.0176552071870648	0.306552657084939	984	Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein	ribosomal large subunit assembly	molecular_function	Noc1p-Noc2p complex
YFL023W	BUD27	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RIBOSOME	0.0175749978099784	0.309405784469643	985	Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP	formation of translation preinitiation complex	molecular_function	cytosolic ribosome|cytoplasm
YMR316W	DIA1	hom			0.0175671290649158	0.30897239698168	986	Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	pseudohyphal growth|invasive growth in response to glucose limitation	molecular_function	cytoplasm
YHR005C-A	TIM10	het	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0175480506726177	0.30949818943115	987	Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane	protein import into mitochondrial inner membrane	protein transporter activity|unfolded protein binding	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex|mitochondrial intermembrane space protein transporter complex
YBR114W	RAD16	hom	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0175434156923715	0.309626016697088	988	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|damaged DNA binding|DNA-dependent ATPase activity	nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YLR354C	TAL1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.0174824843035314	0.311309673341102	989	Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate	pentose-phosphate shunt	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	nucleus|cytoplasm
YDL152W_d	YDL152W	het	FF		0.0174796020928823	0.311389463829109	990	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome	Unknown	Unknown	Unknown
YOR064C	YNG1	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0174631834521586	0.312205250203778	991	Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1	histone acetylation|chromatin modification	histone acetyltransferase activity|methylated histone residue binding	NuA3 histone acetyltransferase complex
YAL041W	CDC24	het	FT	CELL CYCLE|SIGNALING|NUCLEUS|SITE OF POLARIZED GROWTH	0.0174360702760889	0.312596228426739	992	Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of exit from mitosis|establishment of cell polarity|small GTPase mediated signal transduction	Rho guanyl-nucleotide exchange factor activity	incipient cellular bud site|nucleus|cellular bud neck|mating projection tip|cellular bud tip|cytoplasm
YGR125W_p	YGR125W	hom			0.0174022302059508	0.313536448260554	993	Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YDL145C	COP1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.017366673999923	0.314526351700768	994	Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport	ubiquitin binding	COPI vesicle coat
YDR483W	KRE2	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.017364016783984	0.314672575608348	995	Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication	N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YIL103W	DPH1	hom			0.0173337645858195	0.315733182650485	996	Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	molecular_function	cytoplasm
YIL075C	RPN2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS	0.0173133554864258	0.316158963675677	997	Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress	proteasome assembly|ubiquitin-dependent protein catabolic process	endopeptidase activity|protein binding, bridging	proteasome regulatory particle, base subcomplex|nucleus|proteasome storage granule
YBR078W	ECM33	hom	FF|FT	CELL WALL ORG/BIOGENESIS|MITOCHONDRION|PLASMA MEMBRANE	0.0172846181174888	0.316818661473993	998	GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p	fungal-type cell wall organization	molecular_function	mitochondrion|fungal-type cell wall|plasma membrane
YOR205C	GEP3	hom	FT	MITOCHONDRION	0.0172576636690295	0.317646209535599	999	Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1)	maturation of SSU-rRNA	molecular_function	mitochondrion|mitochondrial inner membrane
YMR071C	TVP18	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0172572027120773	0.317803533206311	1000	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments	vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|clathrin-coated vesicle
YPR049C	ATG11	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION	0.0172204921076033	0.318617689604368	1001	Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)	piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|protein localization to pre-autophagosomal structure|CVT pathway	protein complex scaffold	pre-autophagosomal structure|extrinsic to membrane
YLR040C_p	YLR040C	hom			0.0171519137332037	0.320621173709661	1002	Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential	biological_process	molecular_function	fungal-type cell wall
YJL124C	LSM1	hom	FF|FT	RNA PROCESSING|NUCLEUS	0.0171083690475632	0.322429491489596	1003	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	RNA binding|RNA cap binding	mRNA cap binding complex|cytoplasmic mRNA processing body|cytoplasm
YJL153C	INO1	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	0.0170573418314702	0.323730418564068	1004	Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element	inositol biosynthetic process	inositol-3-phosphate synthase activity	cytoplasm
YBL074C	AAR2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0170452625445623	0.323567713688848	1005	Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron	assembly of spliceosomal tri-snRNP	molecular_function	U5 snRNP
YCR099C_p	YCR099C	hom			0.0170120091561152	0.324512706773619	1006	Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YDR228C	PCF11	het	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.0169928506107651	0.32556344187747	1007	mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping	mRNA cleavage|termination of RNA polymerase II transcription|mRNA polyadenylation	mRNA binding|RNA polymerase II core binding	mRNA cleavage factor complex
YDR288W	NSE3	het	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0168865829535937	0.328670836366699	1008	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress	DNA repair	DNA binding	Smc5-Smc6 complex|nucleus|cytoplasm
YNL221C	POP1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0168459877992571	0.32947395904708	1009	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YDR091C	RLI1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEOTIDE METABOLISM|NUCLEUS|RIBOSOME	0.016822324743836	0.329937451310248	1010	Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species	translational termination|ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|translational initiation	ATPase activity|iron ion binding	cytosolic ribosome|nucleus|cytoplasm
YPL272C_p	YPL272C	hom			0.0168194052313572	0.330382192752068	1011	Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene	biological_process	molecular_function	cellular_component
YGL090W	LIF1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0168001246196648	0.330576162870461	1012	Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein	double-strand break repair via nonhomologous end joining	chromatin binding	DNA ligase IV complex|nuclear chromatin|nucleus
YDL021W	GPM2	hom	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.0167111295491168	0.333144630354771	1013	Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event	biological_process	phosphoglycerate mutase activity|molecular_function	cytosol|cytoplasm
YMR131C	RRB1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0166048080626943	0.336229984005745	1014	Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p	ribosome biogenesis	molecular_function	nucleolus
YMR312W	ELP6	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.0165808833959536	0.337142991916198	1015	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	protein urmylation|regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex
YOL089C	HAL9	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION	0.0165645064401559	0.337404288872589	1016	Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication	response to salt stress|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	mitochondrion|nucleus
YGL169W	SUA5	het	FT	RNA PROCESSING|TRANSLATION|NUCLEUS|CHROMOSOME	0.0165619169607213	0.33784025242707	1017	Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family	threonylcarbamoyladenosine metabolic process|telomere maintenance|regulation of translational fidelity	single-stranded telomeric DNA binding	cytoplasm
YPL056C_p	LCL1	hom	FT	PLASMA MEMBRANE	0.01653940329508	0.338209107037716	1018	Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan	biological_process	molecular_function	cellular_component
YOR132W	VPS17	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM	0.0165251407238427	0.338553863868369	1019	Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes	retrograde transport, endosome to Golgi	protein transporter activity|phosphatidylinositol-3-phosphate binding	endosome|retromer complex, outer shell|retromer complex
YMR320W_d	YMR320W	hom			0.0164921717256231	0.339518570552722	1020	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR016C	YSC84	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0164908403753152	0.339701618705649	1021	Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication	endocytosis|actin filament organization|actin filament bundle assembly|actin cortical patch localization|actin cytoskeleton organization	actin filament binding	actin cortical patch
YMR119W-A_d	YMR119W-A	hom			0.0164784574735637	0.341581870221863	1022	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAL008W	FUN14	hom	FT	MITOCHONDRION	0.0164459911945077	0.340872819963286	1023	Mitochondrial protein of unknown function	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YPL240C	HSP82	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	0.0164298376876342	0.341707506208368	1024	Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication	proteasome assembly|positive regulation of telomere maintenance via telomerase|box C/D snoRNP assembly|response to stress|protein refolding|protein targeting to mitochondrion|response to osmotic stress|'de novo' protein folding	unfolded protein binding|ATPase activity, coupled	cytoplasm
YFL012W_p	YFL012W	hom			0.0164263209488046	0.341450700856204	1025	Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin	biological_process	molecular_function	cellular_component
YEL017C-A	PMP2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0163170527989675	0.34532044424336	1026	Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication	cation transport	molecular_function	membrane
YOL023W	IFM1	hom	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0163102807440905	0.344872524424389	1027	Mitochondrial translation initiation factor 2	translational initiation|mitochondrial translational initiation|mitochondrial translation	tRNA binding|GTPase activity|translation initiation factor activity	mitochondrion
YBR029C	CDS1	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0163067248219211	0.344977726453529	1028	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids	phosphatidylserine metabolic process|phosphatidylglycerol biosynthetic process	phosphatidate cytidylyltransferase activity	mitochondrion|integral to membrane|endoplasmic reticulum
YNL300W_p	TOS6	hom			0.0162953786528388	0.345313539854839	1029	Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid	biological_process	molecular_function	fungal-type cell wall
YBR133C	HSL7	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|SITE OF POLARIZED GROWTH	0.0162776306718198	0.345839245779228	1030	Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress	G2/M transition of mitotic cell cycle|regulation of cell cycle	protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity	cellular bud neck
YFL051C_p	YFL051C	hom	FT	PLASMA MEMBRANE	0.0162643307503929	0.346233531431598	1031	Putative protein of unknown function; YFL051C is not an essential gene	biological_process	molecular_function	cellular_component
YLL014W	EMC6	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0162587031283263	0.346760225275898	1032	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|integral to membrane|endoplasmic reticulum
YLR014C	PPR1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM|NUCLEUS	0.0162273633638087	0.347330958496763	1033	Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding|zinc ion binding	nucleus
YOL115W	PAP2	hom	FT	CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION|NUCLEUS	0.0162105619881586	0.347830460487528	1034	Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p	polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|base-excision repair|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U4 snRNA 3'-end processing|nuclear mRNA surveillance of mRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation|tRNA modification	5'-deoxyribose-5-phosphate lyase activity|polynucleotide adenylyltransferase activity	nucleolus|nucleus|TRAMP complex
YLR029C	RPL15A	het	FT	TRANSLATION|RIBOSOME	0.0161970968371174	0.348231106521235	1035	Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YNL113W	RPC19	het	FT	NUCLEUS	0.0161862287803078	0.348554691596141	1036	RNA polymerase subunit AC19, common to RNA polymerases I and III	tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase III complex
YFL019C_d	YFL019C	hom			0.0160844988551851	0.351592849176167	1037	Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene	Unknown	Unknown	Unknown
YKL076C_d	PSY1	hom			0.0160752409791286	0.351870164975137	1038	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C	Unknown	Unknown	Unknown
YPL178W	CBC2	hom	FT	RNA PROCESSING|RNA LOCALIZATION|NUCLEUS	0.0160524012044465	0.352842230942825	1039	Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif	mRNA splicing, via spliceosome	RNA cap binding	commitment complex|nuclear cap binding complex
YDL019C	OSH2	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0160483337841464	0.352676944419661	1040	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	endocytosis|maintenance of cell polarity|sterol transport|exocytosis	lipid binding|oxysterol binding|sterol transporter activity|1-phosphatidylinositol binding	endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum|cellular bud neck
YKL042W	SPC42	het	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	0.016028853318168	0.353620897010174	1041	Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane	microtubule nucleation|spindle pole body duplication associated with nuclear envelope	structural constituent of cytoskeleton	central plaque of spindle pole body|intermediate layer of spindle pole body
YKL036C_d	YKL036C	het			0.0160116774244161	0.353777921569642	1042	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W	Unknown	Unknown	Unknown
YOR211C	MGM1	hom	FT	MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0160012509366918	0.354091478289744	1043	Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy	mitochondrion organization|mitochondrial genome maintenance|mitochondrial fusion	GTPase activity	intrinsic to mitochondrial inner membrane|extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial inner boundary membrane|mitochondrial crista|mitochondrial intermembrane space
YLR055C	SPT8	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0159960472840142	0.354248033845368	1044	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters	histone acetylation|negative regulation of transcription from RNA polymerase II promoter|chromatin modification|positive regulation of transcription from RNA polymerase II promoter	TBP-class protein binding|transcription cofactor activity	nucleus|SAGA complex
YPR085C	ASA1	het	FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.0159764633309694	0.354837622548448	1045	Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1	biological_process	molecular_function	ASTRA complex
YJL209W	CBP1	hom	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0159527148172807	0.355840483232635	1046	Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress	mitochondrial mRNA catabolic process|aerobic respiration	mRNA binding	mitochondrion|extrinsic to mitochondrial inner membrane
YHR199C	AIM46	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	0.0159409922156439	0.355907080873107	1047	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YPL216W_p	YPL216W	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS	0.0158751318377337	0.357898160860327	1048	Putative protein of unknown function; YPL216W is not an essential gene	biological_process	molecular_function	cellular_component
YMR245W_d	YMR245W	hom			0.0158371778468103	0.359048755602835	1049	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL203C	ACK1	hom	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|MITOCHONDRION	0.0158225177160815	0.359493806495633	1050	Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria	fungal-type cell wall organization|positive regulation of signal transduction	molecular_function	mitochondrion
YDR324C	UTP4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0157908744555383	0.360455609906012	1051	Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript	positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus|t-UTP complex|90S preribosome
YBL012C_d	YBL012C	hom			0.0157881462382671	0.360538610153719	1052	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR286W	APE3	hom	FT	PROTEOLYSIS	0.0157861162320896	0.360600376582088	1053	Vacuolar aminopeptidase Y, processed to mature form by Prb1p	vacuolar protein catabolic process	aminopeptidase activity	fungal-type vacuole
YMR224C	MRE11	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION	0.015714258529835	0.362791045120367	1054	Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress	DNA repair|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|base-excision repair|ascospore formation|meiotic DNA double-strand break processing|double-strand break repair via break-induced replication|regulation of transcription during meiosis	3'-5' exonuclease activity|protein complex scaffold|double-stranded telomeric DNA binding|adenylate kinase activity|telomeric DNA binding|single-stranded telomeric DNA binding|endodeoxyribonuclease activity|G-quadruplex DNA binding|endonuclease activity	mitochondrion|nucleus|Mre11 complex
YPL132W	COX11	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION|RIBOSOME	0.0156269732247629	0.36546321915356	1055	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p	protein complex assembly|aerobic respiration	copper ion binding	mitochondrial envelope|mitochondrion|mitochondrial ribosome|mitochondrial inner membrane
YJR093C	FIP1	het	FT	RNA PROCESSING|NUCLEUS	0.0156118595146753	0.365927158431424	1056	Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p	mRNA cleavage|mRNA polyadenylation	RNA binding|protein binding, bridging	mRNA cleavage and polyadenylation specificity factor complex
YPL189C-A	COA2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0156099848751978	0.365984729057361	1057	Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrial matrix
YLR271W_p	YLR271W	hom	FT	NUCLEUS	0.0156086019038606	0.367676133492759	1058	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YMR277W	FCP1	het	FF|FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.0156023668538549	0.366290212040395	1059	Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)	dephosphorylation of RNA polymerase II C-terminal domain|regulation of transcription from RNA polymerase II promoter	protein serine/threonine phosphatase activity	nucleus
YJR090C	GRR1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON|UBIQUITIN LIGASE COMPLEX	0.0155783123002792	0.366958255233581	1060	F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|cell cycle arrest in response to pheromone|G1/S transition of mitotic cell cycle|response to DNA damage stimulus|protein ubiquitination	ubiquitin-protein ligase activity|protein binding, bridging	cellular bud neck contractile ring|SCF ubiquitin ligase complex|nucleus|cytoplasm
YDR538W	PAD1	hom	FT	KETONE METABOLISM|MITOCHONDRION	0.0155582176456359	0.36757674434771	1061	Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX	cinnamic acid catabolic process|aromatic compound catabolic process	mRNA binding|carboxy-lyase activity	mitochondrion
YPR027C_p	YPR027C	hom			0.0155446837435496	0.367993667012003	1062	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YCR050C_p	YCR050C	hom			0.0155368234286039	0.368307362674999	1063	Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein	biological_process	molecular_function	cellular_component
YOR150W	MRPL23	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0154942751859013	0.369549130954795	1064	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOR168W	GLN4	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION	0.0154684413575761	0.370347869922125	1065	Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions	glutaminyl-tRNA aminoacylation	glutamine-tRNA ligase activity	cytosol|mitochondrion
YDR290W_d	YDR290W	hom			0.0154618838680971	0.370550787005917	1066	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103	Unknown	Unknown	Unknown
YLR384C	IKI3	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.0154396699392585	0.371238694720434	1067	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YLR057W	MNL2	hom	FT	PROTEOLYSIS|ENDOPLASMIC RETICULUM	0.0153562214171005	0.373829948402044	1068	Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene	ER-associated protein catabolic process	molecular_function	endoplasmic reticulum
YMR126C_p	DLT1	hom			0.0153257101789019	0.374851393931273	1069	Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)	biological_process	molecular_function	cellular_component
YBR260C	RGD1	hom	FT	SIGNALING|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0153003152519978	0.37557219541138	1070	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization	response to acid|osmosensory signaling pathway	Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding	cellular bud|mating projection tip|actin cortical patch
YNR064C	YNR064C	hom			0.0152879225756496	0.375959075623901	1071	Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides	response to toxin	epoxide hydrolase activity	cellular_component
YDR527W	RBA50	het	FF|FT	TRANSCRIPTION FROM RNA POL II	0.0152709356314782	0.376489781196929	1072	Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1	transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YML075C	HMG1	hom	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0152575361984358	0.3772646816921	1073	HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress	ergosterol biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway	hydroxymethylglutaryl-CoA reductase (NADPH) activity	nuclear envelope|integral to membrane|endoplasmic reticulum membrane
YGR090W	UTP22	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0152445991687196	0.377526970444969	1074	Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	molecular_function	small-subunit processome|nucleolus|nucleus|UTP-C complex|90S preribosome|CURI complex
YBL048W_d	RRT1	hom			0.0152254276035999	0.37798493595719	1075	Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YCL051W	LRE1	hom	FT	CELL WALL ORG/BIOGENESIS	0.0151994482820632	0.378728246125429	1076	Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; <br>LRE1 has a paralog, HLR1, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cellular_component
YBR277C_d	YBR277C	hom			0.0151800582712744	0.379336809365443	1077	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W	Unknown	Unknown	Unknown
YLR208W	SEC13	het	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|NUCLEAR PORE	0.0151521343619228	0.38021426811243	1078	Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress	positive regulation of transcription, DNA-dependent|ER-associated protein catabolic process|positive regulation of GTPase activity|nuclear pore distribution|COPII-coated vesicle budding	structural molecule activity	COPII vesicle coat|nuclear pore outer ring|Seh1-associated complex
YEL042W	GDA1	hom	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0151363198854758	0.380711762181526	1079	Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate	protein glycosylation	guanosine-diphosphatase activity|uridine-diphosphatase activity	Golgi apparatus
YLR048W	RPS0B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|RIBOSOME	0.0151189406150185	0.381258942430421	1080	Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR348C	PAL1	hom	FT	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0151164938613436	0.381336016343393	1081	Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cell cortex|cellular bud neck|mating projection tip
YJL111W	CCT7	het	FF		0.0150796940733142	0.38249638005354	1082	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance	protein folding	unfolded protein binding	chaperonin-containing T-complex|cytoplasm
YDR035W	ARO3	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS|MITOCHONDRION	0.0150756042418898	0.383051496887893	1083	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan	aromatic amino acid family biosynthetic process	3-deoxy-7-phosphoheptulonate synthase activity	mitochondrion|nucleus|cytoplasm
YFL005W	SEC4	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION|ENDOMEMBRANE SYSTEM|MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON	0.0150080517049121	0.384761590532291	1084	Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane	bipolar cellular bud site selection|autophagy|exocytosis|Golgi to plasma membrane transport|small GTPase mediated signal transduction|ascospore-type prospore assembly|membrane addition at site of cytokinesis|vesicle fusion|cytokinesis	GTP binding|GTPase activity	mitochondrial outer membrane|vesicle|incipient cellular bud site|mitochondrion|transport vesicle|actin cap|plasma membrane
YLR340W	RPP0	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	0.0150062675935205	0.3858832330007	1085	Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10	translational elongation|cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|LSU rRNA binding	cytosolic large ribosomal subunit|preribosome, large subunit precursor|90S preribosome|cytoplasm
YKL180W	RPL17A	het	FT	TRANSLATION|RIBOSOME	0.0150028092902764	0.384927668139737	1086	Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit|cytoplasm
YBL041W	PRE7	het	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0149884613086684	0.386091842174211	1087	Beta 6 subunit of the 20S proteasome	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YPL259C	APM1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0149839330217887	0.385526023565823	1088	Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YHR087W	RTC3	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0149667629082702	0.386141621196452	1089	Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress	RNA metabolic process	molecular_function	nucleus|cytoplasm
YOL111C	MDY2	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|NUCLEUS	0.0149617918963226	0.386228594549933	1090	Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes	protein insertion into ER membrane|cell morphogenesis involved in conjugation with cellular fusion|posttranslational protein targeting to membrane	molecular_function	ribosome|TRC complex|nucleus|cytoplasm
YCL017C	NFS1	het	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|COFACTOR METABOLISM|NUCLEUS|MITOCHONDRION	0.0149355673858874	0.387061747437523	1091	Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria	cellular iron ion homeostasis|iron-sulfur cluster assembly|mitochondrial tRNA thio-modification|tRNA thio-modification|tRNA wobble uridine modification	cysteine desulfurase activity	mitochondrion|nucleus
YDR200C	VPS64	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0149263079846957	0.387356180228605	1092	Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance	re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole	molecular_function	endoplasmic reticulum membrane|cytoplasm
YBR103W	SIF2	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0148752945200172	0.388980765753474	1093	WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus	negative regulation of meiosis|negative regulation of chromatin silencing at telomere|regulation of transcription, DNA-dependent|histone deacetylation|positive regulation of stress-activated MAPK cascade	molecular_function	Rpd3L-Expanded complex|nucleus|Set3 complex
YOR036W	PEP12	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.0148405976396013	0.390158774202887	1094	Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin	Golgi to vacuole transport|vacuole inheritance	SNAP receptor activity	endosome|Golgi apparatus
YBL038W	MRPL16	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0148109809263607	0.391034807185028	1095	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome|peptidyltransferase activity	mitochondrion|mitochondrial large ribosomal subunit
YGL035C	MIG1	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|ENDOMEMBRANE SYSTEM|NUCLEUS	0.0148062928114184	0.391184792772775	1096	Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion	negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus|nuclear envelope lumen|cytoplasm
YDL202W	MRPL11	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0148047453362243	0.391234308389755	1097	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YHR034C	PIH1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0147176806439276	0.394167363082329	1098	Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II	protein folding|rRNA processing|regulation of cell size|box C/D snoRNP assembly	molecular_function	R2TP complex|nucleus|small nucleolar ribonucleoprotein complex|cytoplasm
YPL195W	APL5	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0146963504530082	0.394712151220894	1099	Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function	vesicle-mediated transport|Golgi to vacuole transport	protein binding	AP-3 adaptor complex
YMR119W	ASI1	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0146868633361493	0.396288879141777	1100	Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication	ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	integral to membrane|nuclear inner membrane|endoplasmic reticulum membrane
YLR153C	ACS2	het	FT	CHROMATIN ORGANIZATION|COFACTOR METABOLISM|NUCLEUS	0.0146654968194603	0.395705494855876	1101	Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions	histone acetylation|acetyl-CoA biosynthetic process|replicative cell aging	acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity	cytosol|nucleolus|nucleus
YML092C	PRE8	het	FF|FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	0.0146535615838116	0.396301524102122	1102	Alpha 2 subunit of the 20S proteasome	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YDR302W	GPI11	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0146528028413773	0.396114619890228	1103	ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog	GPI anchor biosynthetic process	mannose-ethanolamine phosphotransferase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YML036W	CGI121	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|CHROMOSOME	0.0146249102518603	0.397225739422029	1104	Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification	telomere maintenance|positive regulation of transcription from RNA polymerase II promoter	molecular_function	EKC/KEOPS complex
YFR034C	PHO4	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0146176211337423	0.397531516517989	1105	Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability	cellular response to phosphate starvation|positive regulation of phosphate metabolic process|phosphate-containing compound metabolic process|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YPR039W_d	YPR039W	hom			0.014612177461974	0.397425684941548	1106	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W	Unknown	Unknown	Unknown
YNL112W	DBP2	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION	0.0145979271133354	0.398238179099665	1107	ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|rRNA processing	RNA helicase activity	mitochondrion|nucleus|cytoplasm
YGL007W_d	BRP1	hom	FF		0.0145412863456263	0.399719742345425	1108	Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1	Unknown	Unknown	Unknown
YGR281W	YOR1	hom	FT	NUCLEOTIDE METABOLISM|PLASMA MEMBRANE	0.0145169115179582	0.400510354411159	1109	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR)	transport|response to drug	xenobiotic-transporting ATPase activity	integral to membrane|plasma membrane
YGR122W	YGR122W	hom	FF|FT	TRANSCRIPTION FROM RNA POL II	0.0145108614170206	0.400706738441902	1110	Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	cytoplasm
YGR083C	GCD2	het	FT	TRANSLATION	0.0144091854783509	0.40401574580102	1111	Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression	regulation of translational initiation	enzyme regulator activity|guanyl-nucleotide exchange factor activity|translation initiation factor activity	eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YKL096C-B_p	YKL096C-B	hom			0.0143804989595163	0.404952286894161	1112	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YMR319C	FET4	hom	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.0143140546876054	0.407616511802441	1113	Low-affinity Fe(II) transporter of the plasma membrane	intracellular copper ion transport|zinc ion transport|low-affinity iron ion transport|copper ion import	copper ion transmembrane transporter activity|iron ion transmembrane transporter activity	integral to membrane|plasma membrane|integral to plasma membrane
YCL011C	GBP2	hom	FT	RNA LOCALIZATION|NUCLEUS|CHROMOSOME	0.0142885631598692	0.408172266629574	1114	Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication	poly(A)+ mRNA export from nucleus|telomere maintenance	RNA binding|telomeric DNA binding	nucleus|cytoplasmic stress granule
YOR006C	TSR3	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0142873906534793	0.408000960681818	1115	Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress	maturation of SSU-rRNA	molecular_function	nucleus|cytoplasm
YDR448W	ADA2	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0142731660619661	0.408467921530747	1116	Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes	chromatin silencing at rDNA|chromatin modification|regulation of transcription from RNA polymerase II promoter|positive regulation of histone acetylation|chromatin silencing at telomere	chromatin binding|transcription coactivator activity|histone acetyltransferase activity|phosphatidylserine binding	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YCR087W_d	YCR087W	hom			0.0142601971343029	0.408893938908832	1117	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene	Unknown	Unknown	Unknown
YDL226C	GCS1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|MITOCHONDRION|GOLGI APPARATUS|CYTOSKELETON	0.0142154118880208	0.410367124408019	1118	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p	retrograde vesicle-mediated transport, Golgi to ER|Golgi to plasma membrane protein transport|actin filament reorganization involved in cell cycle|ER to Golgi vesicle-mediated transport	actin binding|ARF GTPase activator activity|GTPase activator activity	endosome|trans-Golgi network|endoplasmic reticulum-Golgi intermediate compartment|cytoskeleton
YMR022W	UBC7	hom	FT	CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0142060961082064	0.410673957340765	1119	Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly	fungal-type cell wall organization|chromatin assembly or disassembly|ER-associated protein catabolic process	ubiquitin-protein ligase activity	endoplasmic reticulum membrane
YBL075C	SSA3	hom	FT	PROTEIN LOCALIZATION	0.014205884146795	0.410680940277636	1120	ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity	cytosol
YBR035C	PDX3	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	0.01418834416672	0.411259028260396	1121	Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism	fatty acid metabolic process	pyridoxamine-phosphate oxidase activity	cellular_component
YBR246W	RRT2	hom	FT	VESICLE-MEDIATED TRANSPORT	0.0141727351585212	0.411843607999364	1122	Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription	peptidyl-diphthamide biosynthetic process from peptidyl-histidine|endocytic recycling	molecular_function	endosome|cytoplasm
YOR278W	HEM4	het	FT	COFACTOR METABOLISM	0.0141263053852421	0.413307591592136	1123	Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria	heme biosynthetic process	uroporphyrinogen-III synthase activity	cellular_component
YKL135C	APL2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE	0.0141109894875195	0.413814261206503	1124	Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YJL088W	ARG3	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.0140777885245666	0.414913852585436	1125	Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine	arginine biosynthetic process|ornithine metabolic process	ornithine carbamoyltransferase activity	cytosol
YNL098C	RAS2	hom	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS|PLASMA MEMBRANE	0.0140135557806737	0.417046087741621	1126	GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes	pseudohyphal growth|ascospore formation|activation of adenylate cyclase activity|regulation of protein localization|replicative cell aging|positive regulation of transcription by galactose|Ras protein signal transduction	GTP binding|GTPase activity	plasma membrane
YBL090W	MRP21	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0139633283589067	0.418717900270134	1127	Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences	mitochondrial translational initiation|mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YKR073C_d	YKR073C	hom			0.013960681432559	0.418806112043979	1128	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR281C	DUG2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS|NUCLEUS	0.0139526516281953	0.41907378109895	1129	Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	peptidase activity|gamma-glutamyltransferase activity|omega peptidase activity	nucleus|cytoplasm
YDR199W_d	YDR199W	hom			0.0139495406959628	0.419246864804749	1130	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity	Unknown	Unknown	Unknown
YNR041C	COQ2	hom	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.0138391729848272	0.422867271483055	1131	Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis	ubiquinone biosynthetic process	4-hydroxybenzoate octaprenyltransferase activity	mitochondrion|integral to mitochondrial membrane|integral to membrane
YBR300C_d	YBR300C	hom			0.0138368555055047	0.422944951623698	1132	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene	Unknown	Unknown	Unknown
YPL086C	ELP3	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION|NUCLEUS	0.0138218810009685	0.423447086911425	1133	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	histone acetyltransferase activity	Elongator holoenzyme complex|nucleus|cytoplasm
YPR119W	CLB2	hom	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0138213676956555	0.423464305594521	1134	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|spindle pole body|cellular bud neck|spindle|cytoplasm
YPL144W	POC4	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS	0.0138119842513812	0.423779142777439	1135	Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions	proteasome assembly|chaperone-mediated protein complex assembly	molecular_function	intracellular|cytoplasm
YGR029W	ERV1	het	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.0138033623412994	0.424068549277296	1136	Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)	cellular response to oxidative stress|cellular iron ion homeostasis|protein import into mitochondrial intermembrane space	thiol oxidase activity|flavin-linked sulfhydryl oxidase activity	mitochondrion|mitochondrial intermembrane space
YDR525W_d	API2	hom			0.0137740568359099	0.425329369559165	1137	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology	Unknown	Unknown	Unknown
YDR184C	ATC1	hom	FT	CELL CYCLE|CELL DIVISION|NUCLEUS	0.0137481264475068	0.425925358486344	1138	Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress	bipolar cellular bud site selection|response to stress	molecular_function	nucleus
YPL102C_d	YPL102C	hom			0.0136050520604351	0.430756937415365	1139	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4	Unknown	Unknown	Unknown
YJR049C	UTR1	hom	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM|NUCLEUS	0.0135911418469977	0.431228370444095	1140	ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication	cellular iron ion homeostasis|NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	nucleus|cytoplasm
YCR092C	MSH3	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0135897994423837	0.43127388188703	1141	Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability	mismatch repair|mitotic recombination|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination	DNA insertion or deletion binding|mismatched DNA binding|double-strand/single-strand DNA junction binding|loop DNA binding|Y-form DNA binding	MutSbeta complex|nucleus|cytoplasm
YMR268C	PRP24	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	0.0135695932187222	0.431959268209422	1142	Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling	assembly of spliceosomal tri-snRNP|spliceosomal complex assembly	U6 snRNA binding|snRNA binding	U6 snRNP
YOR362C	PRE10	het	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	0.013549580471852	0.432638713194277	1143	Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	mRNA binding	mitochondrion|proteasome core complex, alpha-subunit complex|nucleus|proteasome storage granule|nuclear outer membrane-endoplasmic reticulum membrane network
YNL170W_d	YNL170W	hom			0.0135410583597897	0.432928231732928	1144	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR005W	SSL1	het	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME	0.0135142345957925	0.434045940689515	1145	Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p	phosphorylation of RNA polymerase II C-terminal domain|translational initiation|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YKL013C	ARC19	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.0134780500518897	0.435072263926956	1146	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches	mitochondrion inheritance|actin cortical patch assembly	structural molecule activity	Arp2/3 protein complex
YIL035C	CKA1	hom	FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0132883560605611	0.441563987304511	1147	Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching	regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase activity|protein kinase activity	protein kinase CK2 complex|UTP-C complex
YNR005C_d	YNR005C	hom			0.013270102520801	0.442191572323324	1148	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHL023C	NPR3	hom	FT	CELL CYCLE|SIGNALING|RESPONSE TO NUTRIENT LEVELS	0.0132156425030314	0.444067020939959	1149	Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair	meiosis|regulation of TOR signaling cascade|cellular response to amino acid starvation	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YCR064C_d	YCR064C	hom	FF		0.0132034268305684	0.444556230369204	1150	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31	Unknown	Unknown	Unknown
YDR186C	YDR186C	hom			0.0131779991457597	0.44536600012615	1151	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	ribosome|cytoplasm
YDR162C	NBP2	hom	FF|FT	PROTEIN PHOSPHORYLATION|NUCLEUS	0.013146330430042	0.447071178412116	1152	Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)	negative regulation of protein kinase activity|response to heat|hyperosmotic response	molecular_function	nucleus|cytoplasm
YGR257C	MTM1	hom	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.0131444510280551	0.446593271810338	1153	Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor	manganese ion transport|transport	transporter activity|metallochaperone activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YLR148W	PEP3	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	0.0130593164919788	0.449813746995708	1154	Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|vacuole fusion, non-autophagic|late endosome to vacuole transport|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol binding|protein binding, bridging	fungal-type vacuole membrane|HOPS complex|proteasome storage granule|CORVET complex|extrinsic to vacuolar membrane
YBR196C	PGI1	het	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.0130497689241329	0.450009904129509	1155	Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation	gluconeogenesis|pentose-phosphate shunt|glycolysis	glucose-6-phosphate isomerase activity	cytosol|mitochondrion|plasma membrane
YER090W	TRP2	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.012997332837109	0.452914867894737	1156	Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p	tryptophan biosynthetic process	anthranilate synthase activity	anthranilate synthase complex|cytoplasm
YIL170W	HXT12	hom			0.0129966017019362	0.451655843856118	1157	Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family	hexose transport|biological_process	hexose transmembrane transporter activity|molecular_function	integral to membrane
YKL139W	CTK1	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.0129738352251041	0.45244878865974	1158	Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13	mRNA 3'-end processing|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of translational fidelity|positive regulation of transcription from RNA polymerase I promoter|peptidyl-serine phosphorylation|positive regulation of DNA-dependent transcription, elongation|protein phosphorylation	protein kinase activity|cyclin-dependent protein kinase activity	nucleoplasm|nucleolus|nucleus|polysome|carboxy-terminal domain protein kinase complex
YKR028W	SAP190	hom	FT	CELL CYCLE|RNA PROCESSING|SIGNALING	0.0129314029241333	0.453928780238981	1159	Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication	TOR signaling cascade|dephosphorylation|G1/S transition of mitotic cell cycle|tRNA wobble uridine modification	molecular_function	cytoplasm
YHR030C	SLT2	hom	FF|FT	PROTEIN LOCALIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION|NUCLEUS|SITE OF POLARIZED GROWTH	0.0128724172452019	0.457472153019794	1160	Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway	protein phosphorylation|endoplasmic reticulum unfolded protein response|signal transduction|UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|regulation of transcription factor import into nucleus|barrier septum assembly|response to acid|regulation of cell size	MAP kinase activity|protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm|cellular bud tip
YLL048C	YBT1	hom	FT	NUCLEOTIDE METABOLISM	0.0128442992020316	0.457042506549748	1161	Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters	bile acid and bile salt transport	bile acid-exporting ATPase activity	integral to membrane|fungal-type vacuole
YLR200W	YKE2	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEUS	0.0127941429037715	0.458734902224947	1162	Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin	protein folding|tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YJL188C_d	BUD19	hom			0.0127600402942515	0.459933402467647	1163	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YDR177W	UBC1	het	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS	0.0127290972648537	0.46102237672298	1164	Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress	spore germination|vesicle organization|endocytosis|ER-associated protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	proteasome complex
YAR014C	BUD14	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH	0.0127196442877151	0.461488987915352	1165	Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress	regulation of cell shape during vegetative growth phase|regulation of protein localization|regulation of transcription, DNA-dependent|cytoskeleton organization|negative regulation of actin filament polymerization	protein phosphatase type 1 regulator activity	incipient cellular bud site|cellular bud neck|cellular bud tip
YGR204W	ADE3	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.0126940657236455	0.462256974067854	1166	Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine	purine nucleobase biosynthetic process|folic acid-containing compound metabolic process	methylenetetrahydrofolate dehydrogenase (NADP+) activity|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity	nucleus|cytoplasm
YJL159W	HSP150	hom	FT	CELL WALL ORG/BIOGENESIS	0.0125959584748251	0.465724308957248	1167	O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication	fungal-type cell wall organization	structural constituent of cell wall|ATPase activity	fungal-type cell wall|extracellular region
YKR085C	MRPL20	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0125222545114322	0.468338647846765	1168	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDR375C	BCS1	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.0125029166764971	0.469092200905337	1169	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases	protein insertion into mitochondrial membrane from inner side|chaperone-mediated protein complex assembly|mitochondrial respiratory chain complex III assembly	protein transmembrane transporter activity|ATPase activity	mitochondrion|mitochondrial inner membrane
YNL110C	NOP15	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS	0.0123837977453935	0.473535707215578	1170	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm	cytokinesis, actomyosin contractile ring assembly|ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YDR463W	STP1	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS|PLASMA MEMBRANE	0.0123679159341724	0.474169210472736	1171	Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication	positive regulation of transcription, DNA-dependent|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	plasma membrane|nucleus|cytoplasm
YEL033W_p	MTC7	hom			0.0123444139573646	0.475141547939638	1172	Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant	biological_process	molecular_function	cellular_component
YHR012W	VPS29	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM	0.0123274418082967	0.475287759040299	1173	Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval	retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YLR076C_d	YLR076C	het			0.0122794196228848	0.478260304188698	1174	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10	Unknown	Unknown	Unknown
YKL213C	DOA1	hom	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS	0.0122042830595469	0.480562627484299	1175	WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress	double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process	ubiquitin binding	nucleus|cytoplasm
YBL083C_d	YBL083C	hom			0.01217683016608	0.480698710745724	1176	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3	Unknown	Unknown	Unknown
YDR213W	UPC2	hom	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|NUCLEUS	0.0121648178615383	0.481131710669454	1177	Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication	cellular response to hypoxia|positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|membrane|cytoplasm|perinuclear region of cytoplasm
YKL087C	CYT2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION	0.0121114115360181	0.483059381798479	1178	Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1	cytochrome c-heme linkage	holocytochrome-c synthase activity	mitochondrion|mitochondrial intermembrane space
YPL237W	SUI3	het	FT	TRANSLATION|RIBOSOME	0.0120539095694905	0.485139560826946	1179	Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding	translational initiation	translation initiation factor activity	multi-eIF complex|ribosome|eukaryotic translation initiation factor 2 complex
YER088C	DOT6	hom	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING|NUCLEUS|CHROMOSOME	0.0120313372197135	0.485957456741888	1180	Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	chromatin silencing at rDNA|filamentous growth|regulation of transcription from RNA polymerase II promoter|unidimensional cell growth|chromatin silencing at telomere	sequence-specific DNA binding	Rpd3L-Expanded complex|nucleus|Rpd3L complex|cytoplasm
YGR240C	PFK1	hom	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0119628184473586	0.48863931517999	1181	Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes	proton transport|glycolysis	6-phosphofructokinase activity	mitochondrion|6-phosphofructokinase complex|cytoplasm
YMR151W_d	YIM2	hom			0.0118397553514487	0.492929235994628	1182	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1	Unknown	Unknown	Unknown
YLR110C	CCW12	hom	FF|FT	CELL WALL ORG/BIOGENESIS|SITE OF POLARIZED GROWTH	0.0118359360517364	0.493262238922443	1183	Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication	conjugation with cellular fusion|agglutination involved in conjugation with cellular fusion|fungal-type cell wall organization	molecular_function	fungal-type cell wall|mating projection tip|cellular bud tip
YLR355C	ILV5	het	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.011828599584416	0.493336845116732	1184	Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids	mitochondrial genome maintenance|branched-chain amino acid biosynthetic process	double-stranded DNA binding|ketol-acid reductoisomerase activity	mitochondrial nucleoid|mitochondrion
YML048W	GSF2	hom	FF|FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.0116672647031377	0.499251814277322	1185	ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression	protein folding|protein localization to cell surface	unfolded protein binding	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|cytoplasm
YGL026C	TRP5	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.0116461522581662	0.500028629716428	1186	Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis	tryptophan biosynthetic process	tryptophan synthase activity	nucleus|cytoplasm
YPR139C	LOA1	hom	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM	0.0115232366770259	0.504691018448959	1187	Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA	lipid particle organization|cellular triglyceride homeostasis|protein targeting to vacuole	lysophosphatidic acid acyltransferase activity	endoplasmic reticulum|lipid particle|cytoplasm
YJL154C	VPS35	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM	0.0114916815354716	0.505731704489307	1188	Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YFR051C	RET2	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0114328075494563	0.507914311201579	1189	Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER	retrograde vesicle-mediated transport, Golgi to ER|Golgi inheritance|ER to Golgi vesicle-mediated transport|Golgi localization	molecular_function	COPI vesicle coat
YHR143W	DSE2	hom	FF|FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION	0.0113653369610473	0.51042167785031	1190	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP	cytokinesis, completion of separation|pseudohyphal growth	glucosidase activity	extracellular region|fungal-type cell wall
YNL237W	YTP1	hom	FF|FT	MITOCHONDRION	0.0112582490337282	0.514414560940751	1191	Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins	biological_process	molecular_function	integral to membrane|membrane
YDR176W	NGG1	hom	FF|FT	CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0112238329928381	0.515701236163048	1192	Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex	histone acetylation|chromatin modification	histone acetyltransferase activity|transcription cofactor activity	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YLL040C	VPS13	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|MITOCHONDRION|GOLGI APPARATUS	0.0112206002473481	0.515822181021725	1193	Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively	protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole|ascospore-type prospore membrane assembly	molecular_function	endosome|mitochondrion|prospore membrane|extrinsic to membrane
YEL009C	GCN4	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.0111775603398689	0.517433808978794	1194	Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels	nitrogen catabolite activation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription initiation from RNA polymerase II promoter|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels	chromatin binding|TFIID-class binding transcription factor activity|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding transcription factor activity	nucleus
YJL073W	JEM1	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.0111530249154698	0.51841607890081	1195	DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2	karyogamy involved in conjugation with cellular fusion|ER-associated protein catabolic process|protein folding in endoplasmic reticulum	unfolded protein binding|chaperone binding	endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YGR228W_d	YGR228W	hom			0.011110424899523	0.519952884655973	1196	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C	Unknown	Unknown	Unknown
YDR372C	VPS74	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS	0.0110962561432914	0.520796423192397	1197	Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33	retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum unfolded protein response|protein localization to Golgi apparatus	enzyme binding|phosphatidylinositol-4-phosphate binding	cytosol|Golgi apparatus|nucleus|extrinsic to membrane|cytoplasm
YDR337W	MRPS28	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.011050662232601	0.522262664439937	1198	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome|RNA binding	mitochondrion|mitochondrial small ribosomal subunit
YBR257W	POP4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0110292617013534	0.52300673333349	1199	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YIL005W	EPS1	hom	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0109386937486607	0.526425278910608	1200	ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family	protein retention in ER lumen|ER-associated protein catabolic process	unfolded protein binding|protein disulfide isomerase activity|chaperone binding	endoplasmic reticulum membrane
YIL021W	RPB3	het	FF|FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.0107817253022815	0.532621651137832	1201	RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit	termination of RNA polymerase II transcription|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	nucleoplasm|DNA-directed RNA polymerase II, core complex
YDL195W	SEC31	het	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH	0.0107520573239936	0.533505792686907	1202	Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance	COPII-coated vesicle budding	structural molecule activity	COPII vesicle coat|mating projection tip
YJL024C	APS3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.0107352921903758	0.534144166386245	1203	Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress	Golgi to vacuole transport|vesicle-mediated transport	molecular_function	AP-3 adaptor complex
YGR078C	PAC10	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS	0.0106733957991447	0.537295107480882	1204	Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding	tubulin complex assembly	tubulin binding	prefoldin complex|polysome|cytoplasm
YGL012W	ERG4	hom	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOPLASMIC RETICULUM	0.0105898082982957	0.539699961843901	1205	C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol	ergosterol biosynthetic process	delta24(24-1) sterol reductase activity	integral to membrane|endoplasmic reticulum
YHR186C	KOG1	het	FT	SIGNALING|RESPONSE TO NUTRIENT LEVELS|MITOCHONDRION|PLASMA MEMBRANE	0.0105639283551167	0.540691296276574	1206	Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors	TOR signaling cascade|regulation of cell growth|cellular response to starvation	ubiquitin binding	TORC1 complex|fungal-type vacuole membrane|mitochondrion|plasma membrane
YDL090C	RAM1	hom	FF|FT	PROTEIN PRENYLATION	0.010549276376902	0.542522075254513	1207	Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit	protein farnesylation	protein farnesyltransferase activity	protein farnesyltransferase complex
YOR323C	PRO2	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS	0.0105013254101033	0.544056758508614	1208	Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis	proline biosynthetic process	glutamate-5-semialdehyde dehydrogenase activity	nucleus|cytoplasm
YLR275W	SMD2	het	FT	RNA PROCESSING|NUCLEUS	0.0104988787489484	0.543728649373721	1209	Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2	mRNA splicing, via spliceosome	molecular_function	U1 snRNP|U4/U6 x U5 tri-snRNP complex|U2-type prespliceosome|U5 snRNP
YDR466W	PKH3	hom	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	0.0104748555965869	0.544110178762807	1210	Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant	MAPK cascade involved in cell wall biogenesis|protein phosphorylation	protein kinase activity	cellular_component
YMR031W-A_d	YMR031W-A	hom			0.0103158206156771	0.550538438119674	1211	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C	Unknown	Unknown	Unknown
YOR213C	SAS5	hom	FT	CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME|HISTONE ACETYLTRANSFERASE	0.0102953343444779	0.551033235136454	1212	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity	chromatin silencing at telomere	acetyltransferase activity|histone acetyltransferase activity	nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YGL066W	SGF73	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RNA LOCALIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.0102910255794613	0.551199929010962	1213	SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay	histone deubiquitination|mRNA export from nucleus|histone acetylation|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|protein complex assembly|chromatin modification	histone acetyltransferase activity|enzyme activator activity|structural molecule activity	DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YLR324W	PEX30	hom	FF|FT	PEROXISOME ORGANIZATION	0.0101786900549876	0.555554596385782	1214	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p	peroxisome organization	molecular_function	integral to membrane|peroxisome|integral to peroxisomal membrane
YGR106C	VOA1	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0101312308041937	0.557693328781791	1215	Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval	protein complex assembly	molecular_function	fungal-type vacuole membrane|endoplasmic reticulum membrane
YIL039W	TED1	hom	FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.0101032813648202	0.558487190180476	1216	Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	ER to Golgi vesicle-mediated transport	molecular_function	endoplasmic reticulum
YJR043C	POL32	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.0100081454908359	0.562372573246535	1217	Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p	RNA-dependent DNA replication|lagging strand elongation|postreplication repair|base-excision repair|DNA replication, removal of RNA primer|nucleotide-excision repair|mismatch repair|double-strand break repair via break-induced replication|leading strand elongation	DNA-directed DNA polymerase activity|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity	delta DNA polymerase complex|nucleus
YMR032W	HOF1	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.00998406185235798	0.563138844048995	1218	Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p	cytokinesis after mitosis|barrier septum assembly involved in cell cycle cytokinesis|response to DNA damage stimulus|cytokinesis	cytoskeletal protein binding	cellular bud neck contractile ring|cellular bud neck septin ring
YJL014W	CCT3	het	FF		0.00995684760028437	0.564435740134643	1219	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	protein folding	unfolded protein binding	chaperonin-containing T-complex
YGR166W	TRS65	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|GOLGI APPARATUS	0.00994733507657175	0.564575587125907	1220	Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response	intra-Golgi vesicle-mediated transport|protein complex assembly	Rab guanyl-nucleotide exchange factor activity	TRAPP complex|trans-Golgi network
YBR003W	COQ1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.00994180973829308	0.564791889571169	1221	Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis	ubiquinone biosynthetic process	trans-hexaprenyltranstransferase activity	mitochondrion
YEL022W	GEA2	hom	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|GOLGI APPARATUS	0.00991384857049578	0.565887106232162	1222	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication	retrograde vesicle-mediated transport, Golgi to ER|secretory granule organization|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization	ARF guanyl-nucleotide exchange factor activity	integral to membrane|Golgi cis cisterna|extrinsic to membrane
YBR255W	MTC4	hom			0.00989449667701858	0.566645700819078	1223	Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1	biological_process	molecular_function	cytoplasm
YOR002W	ALG6	hom	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00984076464697805	0.568754549236268	1224	Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease	oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation|aerobic respiration	transferase activity, transferring hexosyl groups|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	integral to membrane|endoplasmic reticulum
YPL238C_d	YPL238C	het	FF		0.0098245709763655	0.569563605021439	1225	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W	Unknown	Unknown	Unknown
YCR053W	THR4	hom	FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|AMINO ACID METABOLISM|NUCLEUS	0.00975383999720133	0.572575334305824	1226	Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway	endocytosis|threonine metabolic process	threonine synthase activity	nucleus|cytoplasm
YBL051C	PIN4	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	0.00964149703612155	0.576607863581117	1227	Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage	G2/M transition of mitotic cell cycle|DNA damage checkpoint	molecular_function	cytoplasm
YBR202W	MCM7	het	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME	0.00964089303167153	0.57663174543691	1228	Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex	S phase of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter|DNA replication initiation|DNA strand elongation involved in DNA replication|DNA unwinding involved in replication|pre-replicative complex assembly|double-strand break repair via break-induced replication|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	DNA replication origin binding|single-stranded DNA-dependent ATPase activity|transcription cofactor activity|single-stranded DNA binding|ATP-dependent 3'-5' DNA helicase activity|ATP binding|four-way junction helicase activity|DNA helicase activity|chromatin binding	replication fork protection complex|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YGR267C	FOL2	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.00962627323796045	0.577209942619904	1229	GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway	folic acid-containing compound biosynthetic process	GTP cyclohydrolase I activity	nucleus|cytoplasm
YPR181C	SEC23	het	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.00949789930249801	0.582298678972229	1230	GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p	regulation of COPII vesicle coating	GTPase activator activity	COPII vesicle coat
YGR261C	APL6	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00946780049853512	0.583494817538371	1231	Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools	vesicle-mediated transport|Golgi to vacuole transport	molecular_function	AP-3 adaptor complex
YGL116W	CDC20	het	FF|FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.0094477347594497	0.584292873347976	1232	Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress	spindle checkpoint|activation of mitotic anaphase-promoting complex activity|meiotic anaphase I|positive regulation of protein catabolic process|activation of anaphase-promoting complex activity involved in meiotic cell cycle|positive regulation of mitotic metaphase/anaphase transition|cyclin catabolic process	anaphase-promoting complex binding|ubiquitin-protein ligase activator activity	mitotic checkpoint complex|anaphase-promoting complex
YDR451C	YHP1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS|CHROMOSOME	0.00936179793786085	0.587716487741005	1233	Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nuclear chromatin|nucleus
YOR279C	RFM1	hom	FT	GENE SILENCING|NUCLEUS	0.00931639895015434	0.589528862286469	1234	DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance	chromatin silencing|chromatin silencing at silent mating-type cassette	unfolded protein binding	histone deacetylase complex|nucleus
YPL172C	COX10	hom	FT	COFACTOR METABOLISM|MITOCHONDRION	0.00927031927629843	0.591592302825068	1235	Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders	heme a biosynthetic process	protoheme IX farnesyltransferase activity	mitochondrion|integral to membrane
YCR094W	CDC50	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|GOLGI APPARATUS	0.00916649978492837	0.595805591851205	1236	Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication	intracellular protein transport|phospholipid translocation|endocytosis|actin cortical patch localization	phospholipid-translocating ATPase activity	trans-Golgi network|late endosome membrane
YOL038W	PRE6	het	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	0.00910654155734969	0.597939863343244	1237	Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YDR170C	SEC7	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS|GOLGI APPARATUS	0.00910209347826731	0.598118728796895	1238	Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|autophagic vacuole assembly	ARF guanyl-nucleotide exchange factor activity	trans-Golgi network|cytosol|late endosome|integral to membrane|Golgi-associated vesicle
YMR073C	IRC21	hom	FF		0.00905491879436512	0.6004524793073	1239	Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study	response to drug	molecular_function	cytoplasm
YLR009W	RLP24	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	0.00899124312640809	0.60290876984373	1240	Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp	ribosomal large subunit biogenesis	molecular_function	nucleolus|preribosome, large subunit precursor
YDR455C_d	YDR455C	hom	FF		0.00891920190802097	0.605494057205956	1241	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W	Unknown	Unknown	Unknown
YJR007W	SUI2	het	FF|FT	TRANSLATION|RIBOSOME	0.00887095513711449	0.607607156514499	1242	Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress	translational initiation	translation initiation factor activity	ribosome|multi-eIF complex|eukaryotic translation initiation factor 2 complex|cytoplasm
YNL126W	SPC98	het	FF|FT	CELL CYCLE|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	0.00883844047160297	0.608763769880938	1243	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque	microtubule nucleation|mitotic spindle organization in nucleus	structural constituent of cytoskeleton	outer plaque of spindle pole body|gamma-tubulin small complex, spindle pole body|inner plaque of spindle pole body
YGL094C	PAN2	hom	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	0.00874418719284457	0.612589615977429	1244	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes	mRNA 3'-end processing|postreplication repair|mRNA processing	poly(A)-specific ribonuclease activity	PAN complex|cytoplasm
YIL093C	RSM25	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.00869789148989212	0.614472692032596	1245	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YML041C	VPS71	hom	FF|FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|VACUOLAR TRANSPORT|NUCLEUS|CHROMOSOME	0.00869762864434885	0.61490595715331	1246	Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting	chromatin remodeling|protein targeting to vacuole|histone exchange	nucleosome binding	Swr1 complex|nucleus
YOL012C	HTZ1	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.00860375052132618	0.618309706912117	1247	Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin	nuclear-transcribed mRNA catabolic process, non-stop decay|regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	chromatin binding	nuclear chromatin|chromatin assembly complex
YER041W	YEN1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.00851245104002125	0.622040873596937	1248	Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p	DNA repair|response to DNA damage stimulus	single-stranded DNA specific endodeoxyribonuclease activity|crossover junction endodeoxyribonuclease activity	nucleus|cytoplasm
YDR297W	SUR2	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00849310390439306	0.622832792024509	1249	Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis	sphingolipid metabolic process	sphingosine hydroxylase activity	integral to membrane|endoplasmic reticulum membrane
YGR098C	ESP1	het	FT	CELL CYCLE|LIPID METABOLISM|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CYTOSKELETON	0.00849131961950004	0.622905848496964	1250	Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress	regulation of exit from mitosis|regulation of mitotic spindle elongation|negative regulation of protein phosphatase type 2A activity|apoptotic process|mitotic sister chromatid segregation	cysteine-type endopeptidase activity	mitochondrion|nucleus|cytoplasm|spindle
YHL019C	APM2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00844027587578915	0.624997373016888	1251	Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YJL047C	RTT101	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.00843690457804307	0.625187207794835	1252	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p	replication fork processing|negative regulation of transposition, RNA-mediated|regulation of mitosis|nonfunctional rRNA decay|ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	Cul8-RING ubiquitin ligase complex|nucleus|cytoplasm
YIL052C	RPL34B	hom	FF|FT	TRANSLATION|RIBOSOME	0.00837246358844075	0.627780664057291	1253	Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YCR093W	CDC39	het	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|NUCLEUS	0.00829338999184243	0.631542437801612	1254	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor	response to pheromone involved in conjugation with cellular fusion|regulation of cell cycle|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter	molecular_function	CCR4-NOT core complex|nucleus|cytoplasm
YOR377W	ATF1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM	0.00827468388743736	0.631803265516427	1255	Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism	Unknown|fermentation	alcohol O-acetyltransferase activity	lipid particle
YGL244W	RTF1	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING|NUCLEUS|CHROMOSOME|RNA POL II, HOLOENZYME	0.00826565798753372	0.632175138228598	1256	Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of chromatin silencing at telomere|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|negative regulation of transcription from RNA polymerase II promoter|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|global genome nucleotide-excision repair|snoRNA 3'-end processing|Unknown|transcription elongation from RNA polymerase II promoter	RNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YMR256C	COX7	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.00819831676978689	0.635255494809228	1257	Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YDR367W	KEI1	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00818941652843289	0.635370459489344	1258	Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene	inositolphosphoceramide metabolic process	inositol phosphoceramide synthase regulator activity	integral to membrane|Golgi apparatus|integral to Golgi membrane|inositol phosphoceramide synthase complex|cytoplasm
YJL086C_d	YJL086C	het	FF		0.00818707327128464	0.635618498472754	1259	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1	Unknown	Unknown	Unknown
YBR218C	PYC2	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.00818400223176824	0.635543623917309	1260	Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication	NADPH regeneration|gluconeogenesis	pyruvate carboxylase activity	cytosol
YDL183C	YDL183C	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	0.00815222757812898	0.637107758906718	1261	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene	potassium ion transport|proton transport	molecular_function	integral to mitochondrial inner membrane
YHR172W	SPC97	het	FT	CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	0.00802385479867908	0.642370508886236	1262	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque	microtubule nucleation	structural constituent of cytoskeleton	outer plaque of spindle pole body|gamma-tubulin small complex, spindle pole body|inner plaque of spindle pole body
YDL006W	PTC1	hom	FF|FT	RNA PROCESSING|SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.00794918073469897	0.645814813817659	1263	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation	mitochondrion inheritance|inactivation of MAPK activity involved in osmosensory signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|tRNA splicing, via endonucleolytic cleavage and ligation|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YML097C	VPS9	hom	FF|FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	0.0079357649351312	0.645830123474698	1264	A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin	vacuole inheritance|protein targeting to vacuole	ubiquitin binding|guanyl-nucleotide exchange factor activity	cytosol
YLR202C_d	YLR202C	hom			0.00786126001024059	0.649175087731862	1265	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron	Unknown	Unknown	Unknown
YDR225W	HTA1	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME|RSC COMPLEX	0.0077940381221519	0.651733694546921	1266	Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p	DNA repair|chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter	DNA binding	replication fork protection complex|nuclear nucleosome
YMR211W	DML1	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00775721229873709	0.653271256273562	1267	Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family	plasmid maintenance|mitochondrial genome maintenance	molecular_function	mitochondrion|cytoplasm
YNL081C	SWS2	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.0077553763844353	0.653347948459964	1268	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency	regulation of sporulation resulting in formation of a cellular spore|mitochondrial translation	structural constituent of ribosome	mitochondrial small ribosomal subunit|cytoplasm
YBL106C	SRO77	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|PLASMA MEMBRANE	0.00775120346394118	0.653522278705913	1269	Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication	exocytosis|Golgi to plasma membrane transport	molecular_function	plasma membrane
YDR540C	IRC4	hom	FF|FT	NUCLEUS	0.00769550896535387	0.655850809618452	1270	Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	mitotic recombination	molecular_function	nucleus|cytoplasm
YLR332W	MID2	hom	FT	RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PEROXISOME ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.00767578732613915	0.656676155150315	1271	O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p	UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|cell morphogenesis involved in conjugation|response to acid|response to osmotic stress	transmembrane signaling receptor activity	integral to plasma membrane|mating projection tip
YLR372W	SUR4	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM|ENDOPLASMIC RETICULUM	0.00761977469792874	0.659022550916748	1272	Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis	post-Golgi vesicle-mediated transport|fatty acid elongation|fatty acid biosynthetic process|sphingolipid biosynthetic process	fatty acid elongase activity	integral to membrane|endoplasmic reticulum
YFL036W	RPO41	hom	FT	MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.007558740812182	0.66177244563875	1273	Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation	transcription from mitochondrial promoter|mitochondrial genome maintenance	DNA-directed RNA polymerase activity	mitochondrial nucleoid|mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix
YDR207C	UME6	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|CHROMOSOME	0.00753480225487542	0.66273011693397	1274	Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p	spore germination|positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter during meiosis|lipid particle organization|nitrogen catabolite repression of transcription from RNA polymerase II promoter|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|repressing transcription factor binding|transcription factor binding transcription factor activity	Rpd3L-Expanded complex|Rpd3L complex
YNR016C	ACC1	het	FF|FT	PROTEIN LOCALIZATION|KETONE METABOLISM|LIPID METABOLISM|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.00749908308923796	0.664089772022674	1275	Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;	nuclear envelope organization|protein import into nucleus|fatty acid biosynthetic process	biotin carboxylase activity|acetyl-CoA carboxylase activity	mitochondrion|endoplasmic reticulum membrane
YGL084C	GUP1	hom	FF|FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.00746764826997684	0.665412094253546	1276	Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport	GPI anchor biosynthetic process|glycerol transport|glycerol catabolic process	O-acyltransferase activity	integral to membrane|endoplasmic reticulum|plasma membrane|membrane
YGR115C_d	YGR115C	het	FF		0.00746579556826984	0.665630630731278	1277	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C	Unknown	Unknown	Unknown
YIL083C	CAB2	het	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.0074383439156234	0.666645734947684	1278	Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)	coenzyme A biosynthetic process	phosphopantothenate--cysteine ligase activity	nucleus|cytoplasm
YFL025C	BST1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00735549580348773	0.670647861711372	1279	GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules	protein retention in ER lumen|vesicle organization|ER-associated protein catabolic process|ER to Golgi vesicle-mediated transport|GPI anchor metabolic process	phosphatidylinositol deacylase activity	integral to membrane|endoplasmic reticulum
YML062C	MFT1	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION|NUCLEUS	0.00727724919036099	0.673856644321554	1280	Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance	mRNA export from nucleus|DNA recombination|transcription elongation from RNA polymerase II promoter	protein complex scaffold|nucleic acid binding	THO complex part of transcription export complex|nucleoplasmic THO complex
YKL114C	APN1	hom	FF|FT	RESPONSE TO DNA DAMAGE|NUCLEUS|MITOCHONDRION	0.00726188713084086	0.674093088479822	1281	Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine	base-excision repair	3'-tyrosyl-DNA phosphodiesterase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity	mitochondrion|nucleus
YIL053W	RHR2	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.00721612611299353	0.676029691771213	1282	Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication	glycerol biosynthetic process|response to osmotic stress	glycerol-1-phosphatase activity	nucleus|cytoplasm
YDR158W	HOM2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS	0.0071943682811538	0.677497124583102	1283	Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	methionine biosynthetic process|threonine biosynthetic process|homoserine biosynthetic process	aspartate-semialdehyde dehydrogenase activity	nucleus|plasma membrane|cytoplasm
YJL095W	BCK1	hom	FF|FT	SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|SITE OF POLARIZED GROWTH	0.0071663250197471	0.678139707722561	1284	Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p	intracellular protein kinase cascade|endoplasmic reticulum unfolded protein response|peroxisome degradation|establishment of cell polarity|protein phosphorylation|response to acid|response to nutrient	protein kinase activity|MAP kinase kinase kinase activity	intracellular|mating projection tip
YML121W	GTR1	hom	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|GENE SILENCING|NUCLEUS	0.00715934302143857	0.678435729303143	1285	Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB	phosphate ion transport|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|chromatin silencing at telomere	GDP binding|GTP binding	fungal-type vacuole membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YPR060C	ARO7	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	0.00712640375555019	0.679832951107676	1286	Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis	aromatic amino acid family biosynthetic process	chorismate mutase activity	nucleus|cytoplasm
YFR036W	CDC26	hom	FF|FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.00709091570461475	0.68133951830228	1287	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YGR063C	SPT4	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.00706438350347949	0.682466715475488	1288	Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions	7-methylguanosine mRNA capping|chromosome segregation|chromatin organization|intracellular mRNA localization|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription, DNA-dependent|regulation of transcription-coupled nucleotide-excision repair|chromatin silencing|mRNA splicing, via spliceosome|Unknown	core RNA polymerase I binding transcription factor activity|core RNA polymerase II binding transcription factor activity|rDNA binding	DSIF complex|nuclear telomeric heterochromatin|rDNA heterochromatin|mating-type region heterochromatin|kinetochore
YDL066W	IDP1	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	0.0070479224544993	0.683166404884929	1289	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes	isocitrate metabolic process|glutamate biosynthetic process	isocitrate dehydrogenase (NADP+) activity	mitochondrial nucleoid|mitochondrion
YBR036C	CSG2	hom	FF|FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00702010584425869	0.684349389341493	1290	Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress	cellular calcium ion homeostasis|glycosphingolipid biosynthetic process	enzyme regulator activity	integral to endoplasmic reticulum membrane|integral to membrane
YJR060W	CBF1	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION|NUCLEUS|MITOCHONDRION|CHROMOSOME|KINETOCHORE	0.00701995893371085	0.68435563921008	1291	Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress	regulation of transcription from RNA polymerase II promoter in response to methionine|negative regulation of transcription from RNA polymerase II promoter|methionine biosynthetic process|chromosome segregation|Unknown|chromatin remodeling|negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II repressing transcription factor binding|centromeric DNA binding	chromosome, centromeric region|mitochondrion|nucleus|kinetochore
YKR072C	SIS2	hom	FF|FT	CELL CYCLE|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.00701229999000078	0.684859499721058	1292	Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis	regulation of mitotic cell cycle|response to salt stress|coenzyme A biosynthetic process	phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity	phosphopantothenoylcysteine decarboxylase complex|nucleus|cytoplasm
YNR035C	ARC35	het	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|CYTOSKELETON	0.00696127759028103	0.687074953901284	1293	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin	mitochondrion inheritance|receptor-mediated endocytosis|microtubule cytoskeleton organization|actin cytoskeleton organization	structural molecule activity	cytosol|Arp2/3 protein complex
YDL041W_d	YDL041W	hom	FF		0.00688860890083963	0.689952132862264	1294	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C	Unknown	Unknown	Unknown
YGL212W	VAM7	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	0.00676181183724173	0.69567296451081	1295	Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress	piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle fusion	SNAP receptor activity|phosphatidylinositol-3-phosphate binding	SNARE complex|fungal-type vacuole membrane
YDR456W	NHX1	hom	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS|GOLGI APPARATUS	0.00671107217874062	0.697543492090456	1296	Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion	sodium ion transmembrane transport|potassium ion transmembrane transport|cellular monovalent inorganic cation homeostasis|vacuolar acidification	sodium:hydrogen antiporter activity|potassium:hydrogen antiporter activity	trans-Golgi network|late endosome|fungal-type vacuole membrane|integral to membrane|early endosome
YJL053W	PEP8	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM	0.00655665559920126	0.704170975739085	1297	Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YMR264W	CUE1	hom	FF|FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|UBIQUITIN LIGASE COMPLEX	0.00637509303318238	0.711992338197409	1298	Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication	ER-associated protein catabolic process|establishment of protein localization to endoplasmic reticulum membrane	ubiquitin-protein ligase activator activity	Doa10p ubiquitin ligase complex|mitochondrion|integral to endoplasmic reticulum membrane
YJR139C	HOM6	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEUS	0.00626450263288448	0.717175733242265	1299	Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions	threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process	homoserine dehydrogenase activity	nucleus|cytoplasm
YLR239C	LIP2	hom	FF|FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.00617000838435812	0.72086351694993	1300	Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups	protein lipoylation	ligase activity	mitochondrion
YAL009W	SPO7	hom	FF|FT	CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.00606665056846932	0.725388036913904	1301	Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|integral to membrane
YJR146W_p	YJR146W	hom			0.00595197763566903	0.730336023200616	1302	Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2	biological_process	molecular_function	cellular_component
YHR004C	NEM1	hom	FF|FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.00580818242472002	0.736908696687885	1303	Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|mitochondrion|integral to membrane
YGL033W	HOP2	hom	FF|FT	CELL CYCLE|NUCLEUS|CHROMOSOME	0.00577962693416397	0.737853216248925	1304	Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair	synapsis|reciprocal meiotic recombination	protein binding|double-stranded DNA binding	condensed nuclear chromosome
YMR063W	RIM9	hom	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.00564023934905168	0.744356707060678	1305	Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;	ascospore formation	molecular_function	integral to membrane
YDR080W	VPS41	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING	0.00552492864848319	0.749007891883007	1306	Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole organization|vesicle-mediated transport|protein transport|vacuole fusion, non-autophagic|vacuolar protein processing	Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding	endosome|fungal-type vacuole membrane|HOPS complex
YOR035C	SHE4	hom	FF|FT	CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	0.00545009687653533	0.752617056399061	1307	Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization	mating type switching|intracellular mRNA localization|actin cytoskeleton organization	myosin binding	cytoplasm
YBR069C	TAT1	hom	FF|FT	PLASMA MEMBRANE	0.00542805166042237	0.753799182943698	1308	Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress	amino acid transport|tyrosine transport|tryptophan transport|transmembrane transport	amino acid transmembrane transporter activity|low-affinity tryptophan transmembrane transporter activity	integral to membrane|plasma membrane
YDL077C	VAM6	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	0.00537908522466552	0.755419085290602	1309	Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle-mediated transport|vacuole organization|vacuole fusion, non-autophagic	Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding	fungal-type vacuole membrane|HOPS complex|fungal-type vacuole
YKL041W	VPS24	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM	0.00537743313240187	0.755491807801419	1310	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway	intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	molecular_function	ESCRT III complex|cytoplasm
YNL084C	END3	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON	0.00532007201315617	0.758018093111205	1311	EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p	bipolar cellular bud site selection|ascospore wall assembly|endocytosis|actin filament organization|cytokinesis|actin cortical patch assembly	protein binding, bridging	mating projection tip|actin cortical patch
YMR102C_p	YMR102C	hom			0.00519678481427913	0.763456597672307	1312	Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene	biological_process	molecular_function	cellular_component
YDL192W	ARF1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS|GOLGI APPARATUS	0.0051531976098162	0.765484037747612	1313	ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|intra-Golgi vesicle-mediated transport|macroautophagy	GTPase activity	cytosol|Golgi-associated vesicle
YDR004W	RAD57	hom	FF|FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	0.00502943213357346	0.770857600186348	1314	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p	DNA recombinase assembly|telomere maintenance via recombination|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|protein heterodimerization activity	nucleus|Rhp55-Rhp57 complex
YIL017C	VID28	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS|NUCLEUS	0.00479522356108581	0.781250203448531	1315	GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process|ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	nucleus|GID complex|cytoplasm
YOR070C	GYP1	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION|GOLGI APPARATUS	0.00465210728818582	0.787712892053262	1316	Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion	vesicle-mediated transport	Rab GTPase activator activity	mitochondrion|Golgi apparatus
YKR083C	DAD2	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.00465180009952767	0.787664745013209	1317	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis	mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization	microtubule binding|structural constituent of cytoskeleton	DASH complex|condensed nuclear chromosome kinetochore|mitotic spindle
YOR030W	DFG16	hom	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.00463131492344259	0.788700742603146	1318	Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p	pseudohyphal growth|protein processing	molecular_function	integral to membrane
YDR392W	SPT3	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	0.00456395298540162	0.791550908681337	1319	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters	conjugation with cellular fusion|histone acetylation|pseudohyphal growth|ascospore formation|chromatin modification|invasive growth in response to glucose limitation|transcription from RNA polymerase II promoter	transcription cofactor activity	SLIK (SAGA-like) complex|SAGA complex
YMR052C-A_d	YMR052C-A	hom			0.0044780150294074	0.795387949018671	1320	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YFL010W-A	AUA1	hom			0.00441239918837515	0.798409251879196	1321	Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease	amino acid transport	molecular_function	cellular_component
YER133W	GLC7	het	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CELL DIVISION|CARBOHYDRATE METABOLISM	0.00440746203820804	0.798629965101804	1322	Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest	replication fork processing|glycogen metabolic process|chromosome segregation|regulation of cell shape during vegetative growth phase|termination of RNA polymerase II transcription, poly(A)-coupled|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|rRNA processing|regulation of cell cycle|ascospore formation|protein localization to kinetochore|cell budding|DNA damage checkpoint|meiosis|termination of RNA polymerase II transcription, exosome-dependent|DNA replication checkpoint|response to heat|cellular ion homeostasis|histone dephosphorylation|regulation of carbohydrate metabolic process	protein serine/threonine phosphatase activity	protein phosphatase type 1 complex|mating projection base|condensed nuclear chromosome kinetochore|mRNA cleavage and polyadenylation specificity factor complex|nucleolus|spindle pole body|cellular bud neck
YGR052W_p	FMP48	hom	FT	PROTEIN PHOSPHORYLATION|MITOCHONDRION	0.00423087240494718	0.806449903210512	1323	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation	protein phosphorylation	protein kinase activity	mitochondrion
YDR003W-A_p	YDR003W-A	hom			0.00398242170606769	0.817609550752081	1324	Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YBL026W	LSM2	het	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00382928110421746	0.824506767446907	1325	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|cytoplasmic mRNA processing body|U4/U6 x U5 tri-snRNP complex
YNL051W	COG5	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00380539135391128	0.82581440550936	1326	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YBR289W	SNF5	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS|CHROMOSOME|RSC COMPLEX	0.0037799688233174	0.826730629997452	1327	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions	sucrose catabolic process|double-strand break repair via homologous recombination|chromatin remodeling|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding	SWI/SNF complex|nucleus
YPR180W	AOS1	het	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.0035735402188087	0.836537630624574	1328	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability	protein sumoylation	SUMO activating enzyme activity	nucleus|SUMO activating enzyme complex
YGL025C	PGD1	hom	FF|FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.00338302400762595	0.84479536631974	1329	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity	core mediator complex
YPL139C	UME1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	0.00333399865414399	0.846903803064305	1330	Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter|regulation of meiosis	transcription corepressor activity	Rpd3S complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YMR202W	ERG2	hom	FF|FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00332811863070504	0.847328110009712	1331	C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis	ergosterol biosynthetic process	C-8 sterol isomerase activity	endoplasmic reticulum
YDL024C	DIA3	hom			0.00326298157311771	0.850302612872803	1332	Protein of unknown function, involved in invasive and pseudohyphal growth	pseudohyphal growth|invasive growth in response to glucose limitation	acid phosphatase activity	fungal-type cell wall
YJL201W	ECM25	hom	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	0.00325870111690115	0.850320138893724	1333	Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p	fungal-type cell wall organization|filamentous growth	molecular_function	cytoplasm
YDR188W	CCT6	het			0.00322100162715852	0.852228068402072	1334	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif	protein folding	unfolded protein binding	chaperonin-containing T-complex
YGR031W	IMO32	hom	FT	MITOCHONDRION	0.00319207953670709	0.853345182472048	1335	Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1	biological_process	molecular_function	mitochondrion
YOR349W	CIN1	hom	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	0.00317374447996177	0.854178091069329	1336	Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl	protein folding|tubulin complex assembly|tubulin complex biogenesis	beta-tubulin binding	cellular_component
YJL204C	RCY1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH	0.00310868013458289	0.857135081206943	1337	F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth	early endosome to Golgi transport|endocytosis	SNARE binding	endosome|Golgi apparatus|site of polarized growth
YKL121W_p	DGR2	hom			0.00299156132140703	0.862462826173954	1338	Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds	biological_process	molecular_function	cellular_component
YOR157C	PUP1	het	FF|FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.00294221518732967	0.864909398972782	1339	Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	endopeptidase activity	proteasome storage granule|nucleus|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YGL148W	ARO2	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.00284290183956146	0.869292322507908	1340	Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress	aromatic amino acid family biosynthetic process	chorismate synthase activity|riboflavin reductase (NADPH) activity	cytoplasm
YDR127W	ARO1	hom	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	0.00284025170197309	0.869722457158975	1341	Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids	aromatic amino acid family biosynthetic process	shikimate kinase activity|shikimate 3-dehydrogenase (NADP+) activity|3-phosphoshikimate 1-carboxyvinyltransferase activity|3-dehydroquinate dehydratase activity|3-dehydroquinate synthase activity	cytoplasm
YKL159C	RCN1	hom	FT	SIGNALING	0.00283583051588122	0.869556690647641	1342	Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region	calcium-mediated signaling	protein phosphatase 2B binding|calcium-dependent protein serine/threonine phosphatase regulator activity	cytoplasm
YHR143W-A	RPC10	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.00280924147634573	0.870768942943283	1343	RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress	transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YGL171W	ROK1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION|NUCLEUS	0.00278062196353333	0.872074108082607	1344	RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|snoRNA localization	RNA-dependent ATPase activity	nucleolus|90S preribosome
YBL045C	COR1	hom	FT	OXIDATION-REDUCTION PROCESS|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.0027777757001591	0.87220392825884	1345	Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain	aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YNL064C	YDJ1	hom	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	0.00265408368406819	0.877848889160886	1346	Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family	protein refolding|ER-associated protein catabolic process|protein targeting to mitochondrion|protein targeting to ER|'de novo' protein folding	unfolded protein binding|ATPase activator activity	cytosol|TRC complex|perinuclear region of cytoplasm
YNL297C	MON2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.00249665597729033	0.885059427619941	1347	Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins	transport|endocytosis|protein targeting to vacuole|Golgi to endosome transport	guanyl-nucleotide exchange factor activity	cytosol|endosome|trans-Golgi network|extrinsic to membrane
YNL243W	SLA2	hom	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON	0.00243429544903409	0.887894568237652	1348	Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo	bipolar cellular bud site selection|fungal-type cell wall organization|actin filament organization|endocytosis|exocytosis	protein binding, bridging	incipient cellular bud site|mating projection tip|actin cortical patch
YDR452W	PPN1	hom	FT	NUCLEUS	0.00218596362693284	0.899266479109845	1349	Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress	polyphosphate catabolic process|polyphosphate metabolic process	endopolyphosphatase activity|exopolyphosphatase activity	fungal-type vacuole membrane|nucleus
YGL055W	OLE1	het	FF|FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00207041984860758	0.904564800227584	1350	Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria	unsaturated fatty acid biosynthetic process	electron carrier activity|stearoyl-CoA 9-desaturase activity	integral to endoplasmic reticulum membrane|integral to membrane
YLR233C	EST1	hom	FT	NUCLEUS|CHROMOSOME	0.00206565624147776	0.904783330785587	1351	TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA	telomere maintenance via telomerase|telomere maintenance|G-quadruplex DNA formation	single-stranded DNA binding|RNA binding|telomeric DNA binding	nucleolus|nucleus|telomerase holoenzyme complex
YIR033W	MGA2	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.00199037938073343	0.908237604261868	1352	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	molecular_function	integral to endoplasmic reticulum membrane|nucleus
YGR159C	NSR1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION	0.0019856447932282	0.908454921735682	1353	Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis	ribosomal small subunit assembly|rRNA processing	single-stranded DNA binding|RNA binding	mitochondrion|nucleolus|nucleus
YBR283C	SSH1	hom	FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00197341960443557	0.909016089294433	1354	Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential	SRP-dependent cotranslational protein targeting to membrane	protein transmembrane transporter activity|signal sequence binding	integral to membrane|Ssh1 translocon complex
YGR036C	CAX4	hom	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00189679268722549	0.912534484172962	1355	Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation	lipid biosynthetic process|protein N-linked glycosylation	dolichyldiphosphatase activity	integral to endoplasmic reticulum membrane|integral to membrane
YKL033W	TTI1	het	FT	CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	0.00185673431522191	0.914387206116823	1356	Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	ASTRA complex|mitochondrion|cytoplasm
YBL036C	YBL036C	hom			0.00183640706070676	0.91530835673944	1357	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS	biological_process	pyridoxal phosphate binding	cellular_component
YMR040W	YET2	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.00182254959404188	0.9159575465627	1358	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein	biological_process	molecular_function	ribosome|integral to membrane
YER082C	UTP7	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00181037552689757	0.916516865076711	1359	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus|90S preribosome
YNL220W	ADE12	hom	FT	NUCLEOTIDE METABOLISM	0.00171356573029006	0.920954340014114	1360	Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence	purine nucleotide biosynthetic process	DNA replication origin binding|adenylosuccinate synthase activity	cytoplasm
YMR038C	CCS1	hom	FF|FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|MITOCHONDRION	0.00168707216820629	0.922357854497493	1361	Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress	intracellular copper ion transport	superoxide dismutase copper chaperone activity	cytosol|mitochondrial inner membrane|nucleus
YMR041C	ARA2	hom	FT	OXIDATION-REDUCTION PROCESS	0.00167719118544607	0.922626949517736	1362	NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase	dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinose 1-dehydrogenase [NAD(P)+] activity	cellular_component
YEL049W	PAU2	hom			0.00163379165772115	0.924623035514262	1363	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YDR334W	SWR1	hom	FF|FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	0.00162921798754072	0.92483342139402	1364	Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A	chromatin remodeling|histone exchange	structural molecule activity	Swr1 complex|nucleus
YDR382W	RPP2B	hom	FT	TRANSLATION|RIBOSOME	0.00162167920315878	0.925180212078123	1365	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	translational elongation|cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOL141W	PPM2	hom	FT	RNA PROCESSING|MITOCHONDRION	0.00160051775160645	0.926153733107845	1366	AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p	tRNA methylation|wybutosine biosynthetic process	tRNA methyltransferase activity	mitochondrion|cytoplasm
YMR135W-A_d	YMR135W-A	hom			0.00159866940357687	0.926304597920122	1367	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR111C_p	YJR111C	hom	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.00153622098160974	0.929112342994756	1368	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria	biological_process	molecular_function	mitochondrion
YDL109C_p	YDL109C	hom	FT	LIPID METABOLISM	0.00151126817234868	0.93026081031646	1369	Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication	cellular lipid metabolic process	molecular_function	cellular_component
YER060W-A	FCY22	hom			0.00150454850008672	0.930652767177702	1370	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function	transmembrane transport	nucleobase transmembrane transporter activity	integral to membrane
YDL060W	TSR1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.00150318307913843	0.930632962613485	1371	Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress	rRNA processing|ribosome biogenesis	ribonucleoprotein complex binding	nucleolus|cytoplasm|90S preribosome
YOR260W	GCD1	het	FT	TRANSLATION	0.00148385991743614	0.931532643674999	1372	Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression	regulation of translational initiation	translation initiation factor activity|guanyl-nucleotide exchange factor activity	eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YGL146C_p	RRT6	hom			0.00142928316750994	0.934035226440663	1373	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins	biological_process	molecular_function	membrane
YDR048C_d	YDR048C	hom			0.00130935448694181	0.939559136662274	1374	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR033C	RAV1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM	0.00130663005365461	0.939684658737525	1375	Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate	early endosome to late endosome transport|vacuolar acidification|regulation of protein complex assembly	molecular_function	RAVE complex|cytoplasm|extrinsic to membrane
YHR007C	ERG11	het	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOPLASMIC RETICULUM	0.00129933383626688	0.940020822748794	1376	Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p	ergosterol biosynthetic process	sterol 14-demethylase activity	endoplasmic reticulum
YNL298W	CLA4	hom	FF|FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS	0.00129828325725375	0.940176348976282	1377	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p	negative regulation of gene expression|vacuole inheritance|protein phosphorylation|budding cell apical bud growth|Rho protein signal transduction|regulation of exit from mitosis|establishment of cell polarity|sterol import|response to pheromone|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	nucleus|cellular bud|fungal-type vacuole
YFR003C	YPI1	het	FT	CELL CYCLE|LIPID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.00128569617931182	0.940649189186223	1378	Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance	negative regulation of phosphoprotein phosphatase activity|glycogen metabolic process|cellular ion homeostasis|Unknown|positive regulation of phosphoprotein phosphatase activity|negative regulation of protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint	protein serine/threonine phosphatase inhibitor activity|protein phosphatase type 1 activator activity	nucleus
YJL175W_d	YJL175W	hom			0.00125404278022942	0.942133642829407	1379	Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor	Unknown	Unknown	Unknown
YBR200W	BEM1	hom	FT	SITE OF POLARIZED GROWTH|CYTOSKELETON	0.0012447291100125	0.942537001671804	1380	Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p	establishment of cell polarity|cell morphogenesis involved in conjugation with cellular fusion	protein complex scaffold|phosphatidylinositol-3-phosphate binding	incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip
YAL061W_p	BDH2	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEUS	0.00123875145432651	0.942812486562243	1381	Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3	biological_process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	nucleus|cytoplasm
YML007C-A_p	YML007C-A	hom	FF|FT	MITOCHONDRION	0.00123705955714028	0.942890460197013	1382	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria	biological_process	molecular_function	mitochondrion
YLR390W-A	CCW14	hom	FT	CELL WALL ORG/BIOGENESIS|MITOCHONDRION	0.00123666477428158	0.942942655276392	1383	Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall	fungal-type cell wall organization	structural constituent of cell wall	mitochondrion|fungal-type cell wall
YNL067W	RPL9B	hom	FT	TRANSLATION|RIBOSOME	0.00122963485101438	0.943232645439944	1384	Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR107C	TMN2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	0.00122809977908144	0.943303394189885	1385	Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments	cellular copper ion homeostasis|pseudohyphal growth|vacuolar transport|invasive growth in response to glucose limitation	molecular_function	fungal-type vacuole membrane|integral to membrane
YPL041C_p	YPL041C	hom			0.00121732277219851	0.943858688604688	1386	Protein of unknown function involved in maintenance of proper telomere length	biological_process	molecular_function	cellular_component
YDR429C	TIF35	het	FF|FT	TRANSLATION	0.0012024628536834	0.944485020383814	1387	eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation	translation reinitiation|translational initiation	translation initiation factor activity	eukaryotic translation initiation factor 3 complex
YJL117W	PHO86	hom	FT	VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOPLASMIC RETICULUM	0.00119473065052035	0.944841427837209	1388	Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress	protein folding|ER to Golgi vesicle-mediated transport|regulation of phosphate transport	unfolded protein binding	endoplasmic reticulum
YGR216C	GPI1	het	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM	0.0011903704474816	0.945042411501547	1389	Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs	GPI anchor biosynthetic process	phosphatidylinositol N-acetylglucosaminyltransferase activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane
YPR187W	RPO26	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	0.00118128392570653	0.945461266163781	1390	RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit	tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YFL041W	FET5	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.00117955637838303	0.94556522816676	1391	Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport	iron ion transport	ferroxidase activity	fungal-type vacuole membrane|integral to membrane
YER087W	AIM10	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION	0.00117741274142869	0.945639717862041	1392	Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	proline-tRNA ligase activity	mitochondrion
YPR123C_d	YPR123C	hom	FF		0.00117327134922252	0.94585482627776	1393	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR	Unknown	Unknown	Unknown
YLR039C	RIC1	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS	0.0011709695508963	0.945936738514175	1394	Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes	intracellular protein transport|retrograde transport, endosome to Golgi	guanyl-nucleotide exchange factor activity	nucleus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YDL208W	NHP2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	0.0011706668098558	0.945950694571099	1395	Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing	cleavage involved in rRNA processing|rRNA pseudouridine synthesis|snRNA pseudouridine synthesis	snoRNA binding	box H/ACA snoRNP complex
YLR084C	RAX2	hom	FT	CELL CYCLE|CELL DIVISION|MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.0011702760170388	0.945976753982516	1396	N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p	cellular bud site selection	molecular_function	mitochondrion|cellular bud scar|cellular bud neck|membrane
YFR039C_p	YFR039C	hom			0.00116400047753359	0.946258009968591	1397	Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces	biological_process	molecular_function	cellular_component
YOR246C	ENV9	hom	FF|FT	OXIDATION-REDUCTION PROCESS|VACUOLAR PROTEIN PROCESSING	0.0011588910229986	0.946525431777678	1398	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts	vacuole organization|vacuolar protein processing	oxidoreductase activity	lipid particle
YGR018C_p	YGR018C	hom			0.0011275722499698	0.947937477462623	1399	Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W	biological_process	molecular_function	cellular_component
YIL042C	PKP1	hom	FT	SIGNALING|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|MITOCHONDRION	0.00109565585173197	0.949439264854806	1400	Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p	peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization	protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity	mitochondrion
YGR097W	ASK10	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|RNA POL II, HOLOENZYME	0.00109192628044869	0.949581104060289	1401	Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication	cellular protein catabolic process|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glycerol transport	molecular_function	DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YDR094W_d	YDR094W	hom			0.00106019572137662	0.951044372707807	1402	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2	Unknown	Unknown	Unknown
YOR345C_d	YOR345C	hom			0.00104540651746525	0.951726440009891	1403	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	Unknown	Unknown	Unknown
YKL122C	SRP21	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEUS	0.00103662815019433	0.952131308658247	1404	Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER	signal sequence binding	nucleus|signal recognition particle, endoplasmic reticulum targeting
YKL220C	FRE2	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|PLASMA MEMBRANE	0.0010310098259511	0.95239043888447	1405	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YLR209C	PNP1	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.00103044957232761	0.952416279365446	1406	Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway	guanosine catabolic process|inosine catabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinate nucleotide salvage	nicotinamide riboside hydrolase activity|inosine nucleosidase activity|purine-nucleoside phosphorylase activity	intracellular
YGR160W_d	YGR160W	hom			0.00101164376625533	0.953283685145903	1407	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR088W	CTT1	hom	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	0.00100418536944204	0.953627714306925	1408	Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide	response to reactive oxygen species	catalase activity	cytoplasm
YOR087W	YVC1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	0.000999060832914253	0.953864095852591	1409	Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock	cellular cation homeostasis	voltage-gated ion channel activity|calcium activated cation channel activity|sodium channel activity|calcium channel activity|potassium channel activity	fungal-type vacuole membrane|fungal-type vacuole
YGR110W	CLD1	hom	FT	LIPID METABOLISM|MITOCHONDRION	0.000977741998817655	0.954860973460309	1410	Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58	cardiolipin acyl-chain remodeling|cardiolipin metabolic process	phospholipase A2 activity	mitochondrion
YDR139C	RUB1	hom			0.000957354310943296	0.955788058291771	1411	Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)	protein neddylation	protein tag	cytoplasm
YNL263C	YIF1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.000950827131678466	0.956089187011584	1412	Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|endoplasmic reticulum membrane|ER to Golgi transport vesicle
YML065W	ORC1	het	FT	GENE SILENCING|NUCLEUS|CHROMOSOME	0.000917486803427916	0.957627426093621	1413	Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity	pre-replicative complex assembly|DNA replication initiation|chromatin silencing at silent mating-type cassette	chromatin binding|DNA replication origin binding|ATPase activity|ATP binding	DNA replication preinitiation complex|nucleus|pre-replicative complex|nuclear origin of replication recognition complex
YJL058C	BIT61	hom	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE	0.000902637987791409	0.958312564294086	1414	Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication	fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity	molecular_function	TORC2 complex|plasma membrane|cytoplasm
YBL086C_p	YBL086C	hom			0.000899609861235386	0.958452288672433	1415	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YGL045W	RIM8	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.00088969236973798	0.958928279524575	1416	Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family	meiosis|protein processing|invasive growth in response to glucose limitation|ubiquitin-dependent endocytosis	molecular_function	internal side of plasma membrane
YML108W	YML108W	hom	FT	NUCLEUS	0.000883749446891286	0.95918414360215	1417	Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YKR037C	SPC34	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.000877742733009301	0.959527807413884	1418	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body	microtubule nucleation|mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization	microtubule binding|structural constituent of cytoskeleton	spindle microtubule|DASH complex|condensed nuclear chromosome kinetochore|spindle pole body|spindle
YGL081W_p	YGL081W	hom			0.000873314471523815	0.959665668614842	1419	Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis	biological_process	molecular_function	cellular_component
YFR025C	HIS2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.000869864618336423	0.959836838071126	1420	Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control	histidine biosynthetic process	histidinol-phosphatase activity	intracellular
YDR465C	RMT2	hom	FT	NUCLEUS	0.00086809940686276	0.959978063440369	1421	Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress	peptidyl-arginine methylation	protein-arginine N5-methyltransferase activity	nucleus|cytoplasm
YNR032W	PPG1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	0.000859627762815364	0.960297268091991	1422	Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases	glycogen metabolic process|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YFR016C	YFR016C	hom			0.000848603650662333	0.960806015064652	1423	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene	biological_process	molecular_function	cellular bud|cytoplasm
YBR118W	TEF2	hom	FT	TRANSLATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|CYTOSKELETON|RIBOSOME	0.000845382064927543	0.960954689649636	1424	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication	translational elongation|tRNA export from nucleus	GDP binding|GTP binding|translation elongation factor activity	ribosome|eukaryotic translation elongation factor 1 complex|cytoplasm
YBR097W	VPS15	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS	0.000837306226637396	0.961327391538529	1425	Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery	protein retention in Golgi apparatus|vacuole inheritance|peroxisome degradation|protein phosphorylation|macroautophagy|inositol lipid-mediated signaling|late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding|protein serine/threonine kinase activity	mitochondrion|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|Golgi membrane
YDR242W	AMD2	hom			0.000800333458591509	0.963105469338811	1426	Putative amidase	biological_process	amidase activity	cellular_component
YHR183W	GND1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	0.000785002399831062	0.96376844860344	1427	6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication	cellular response to oxidative stress|pentose-phosphate shunt, oxidative branch	phosphogluconate dehydrogenase (decarboxylating) activity	mitochondrion|cytoplasm
YLR211C_p	YLR211C	hom			0.000766637692136622	0.964589112923117	1428	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron	biological_process	molecular_function	cytoplasm
YMR270C	RRN9	het	FT	NUCLEUS	0.000730832119542474	0.966257050480214	1429	Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I	transcription of nuclear large rRNA transcript from RNA polymerase I promoter	TBP-class protein binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity	nucleolus|RNA polymerase I upstream activating factor complex
YLR004C	THI73	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.000714211048740656	0.967028931755739	1430	Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs	transport	transporter activity	integral to membrane|endoplasmic reticulum
YDR143C	SAN1	hom	FT	PROTEOLYSIS|NUCLEUS	0.000710765138880085	0.967168344637113	1431	Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition	nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to misfolded protein|response to stress	ubiquitin-protein ligase activity	nucleus|cytoplasm
YER064C	VHR2	hom	FT	NUCLEUS	0.000702276258491915	0.967560245566401	1432	Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	regulation of transcription, DNA-dependent	molecular_function	nucleus
YMR093W	UTP15	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|CHROMOSOME	0.000699805742403633	0.967727333069382	1433	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|rDNA heterochromatin|nucleolus|t-UTP complex|90S preribosome
YER068W	MOT2	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	0.000692092883729699	0.968030385501247	1434	Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications	deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|protein polyubiquitination|protein ubiquitination	ubiquitin-protein ligase activity|sequence-specific DNA binding	CCR4-NOT core complex|cytoplasm
YLR186W	EMG1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|CYTOSKELETON	0.000686378302380184	0.968294217739298	1435	Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit biogenesis|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA base methylation|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	rRNA (pseudouridine) methyltransferase activity	small-subunit processome|nucleolus|nucleus|nuclear microtubule|cytoplasm|90S preribosome
YLR414C	PUN1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|PLASMA MEMBRANE	0.000682029378572804	0.968495002280271	1436	Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress	fungal-type cell wall organization|protein oligomerization	molecular_function	integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YCL074W	YCL074W	hom	FT	NUCLEUS	0.000675706374286998	0.968786931281955	1437	Pseudogene: encodes fragment of Ty Pol protein	transposition, RNA-mediated	ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity	retrotransposon nucleocapsid
YCR084C	TUP1	hom	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.000673343679572638	0.968896016437669	1438	General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes	nucleosome positioning|regulation of transcription from RNA polymerase II promoter in response to osmotic stress|histone exchange|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown	ubiquitin binding|histone deacetylase binding|histone binding|phosphatidylinositol-3,5-bisphosphate binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|mediator complex binding	nucleus|transcriptional repressor complex
YGR032W	GSC2	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PLASMA MEMBRANE|CYTOSKELETON	0.000670730909306045	0.969016648210274	1439	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)	ascospore wall assembly|(1->3)-beta-D-glucan biosynthetic process	1,3-beta-D-glucan synthase activity	1,3-beta-D-glucan synthase complex|integral to membrane|actin cap|prospore membrane
YAL068C	PAU8	hom	FT	TRANSCRIPTION FROM RNA POL II	0.000656409453489808	0.969682402394011	1440	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YHR049C-A_d	YHR049C-A	hom			0.000647294338157359	0.970098747578823	1441	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR105W	ADO1	hom	FF|FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.000643432996092334	0.97032136543445	1442	Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle	purine nucleobase metabolic process	adenosine kinase activity	nucleus|cytoplasm
YGL067W	NPY1	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.000631315367705399	0.970836550730431	1443	NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member	NADH metabolic process	NAD+ diphosphatase activity	peroxisome|cytoplasm
YLR328W	NMA1	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.000630724203028437	0.970863847287011	1444	Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication	NAD biosynthetic process	nicotinamide-nucleotide adenylyltransferase activity	nucleus|cytoplasm
YOR347C	PYK2	hom	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.000628647821059137	0.970959722835424	1445	Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication	pyruvate metabolic process	pyruvate kinase activity	cytosol|mitochondrion
YDL110C	TMA17	hom	FT	NUCLEUS	0.00062825360453106	0.971008217965888	1446	Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YDL010W	GRX6	hom	FT	RESPONSE TO OXIDATIVE STRESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.000627562048113155	0.971009857841986	1447	Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication	cellular response to oxidative stress	glutathione-disulfide reductase activity|iron ion binding|protein homodimerization activity|2 iron, 2 sulfur cluster binding	integral to membrane|Golgi apparatus|Golgi lumen|endoplasmic reticulum membrane|fungal-type vacuole|cis-Golgi network
YKL050C	YKL050C	hom			0.000620324060935314	0.971344071088482	1448	Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p	biological_process	molecular_function	cellular_component
YPR011C_p	YPR011C	hom	FT	MITOCHONDRION	0.000620130691103217	0.971357269680098	1449	Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	transport	transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YOL123W	HRP1	het	FT	RNA PROCESSING|NUCLEUS	0.000616739619263268	0.971509584146788	1450	Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences	mRNA cleavage|mRNA polyadenylation	mRNA binding|RNA binding	mRNA cleavage factor complex|nucleus|cytoplasmic stress granule|cytoplasm
YEL040W	UTR2	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|SITE OF POLARIZED GROWTH|CYTOSKELETON	0.00061604374862413	0.971545957988935	1451	Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck	cell wall chitin metabolic process|fungal-type cell wall organization	transferase activity, transferring glycosyl groups	cellular bud neck septin ring|fungal-type cell wall
YML077W	BET5	het	FT	VESICLE-MEDIATED TRANSPORT|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	0.000615519290764974	0.971565933593866	1452	Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi	ER to Golgi vesicle-mediated transport	Rab guanyl-nucleotide exchange factor activity	TRAPP complex
YNL305C	BXI1	hom	FT	SIGNALING|ENDOPLASMIC RETICULUM|MITOCHONDRION	0.000606248120534067	0.971994040408287	1453	Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p	endoplasmic reticulum unfolded protein response|apoptotic process|calcium-mediated signaling	molecular_function	mitochondrion|integral to membrane|endoplasmic reticulum|fungal-type vacuole
YDL184C	RPL41A	hom	FT	TRANSLATION|RIBOSOME	0.000596009087922239	0.972466848735087	1454	Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR177C	ATF2	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	0.000594941744781992	0.972540724069579	1455	Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking	steroid metabolic process|response to toxin|Unknown|sterol acetylation	alcohol O-acetyltransferase activity	integral to endoplasmic reticulum membrane|endoplasmic reticulum|cytoplasm
YML022W	APT1	hom	FT	NUCLEOTIDE METABOLISM|NUCLEUS	0.000593222276389434	0.972595537153609	1456	Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication	AMP biosynthetic process|adenine salvage	adenine phosphoribosyltransferase activity	nucleus|cytoplasm
YPR088C	SRP54	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS	0.000592628302631237	0.972622965560566	1457	Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|SRP-dependent cotranslational protein targeting to membrane|protein targeting to ER	7S RNA binding|GTP binding|signal sequence binding	signal recognition particle, endoplasmic reticulum targeting
YBR147W	RTC2	hom	FT	MITOCHONDRION	0.000587426953704132	0.972863153838593	1458	Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter	biological_process	molecular_function	mitochondrion|integral to membrane
YMR006C	PLB2	hom	FT	LIPID METABOLISM	0.000581485651929263	0.973137514722847	1459	Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine	glycerophospholipid metabolic process	lysophospholipase activity	extracellular region|fungal-type cell wall
YHL006C	SHU1	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	0.00058060242662398	0.973178301086054	1460	Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function	recombinational repair|maintenance of rDNA	molecular_function	nucleolus|Shu complex
YGL181W	GTS1	hom	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM|NUCLEUS|CYTOSKELETON	0.000576219400637637	0.97338070539107	1461	Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations	endocytosis|ultradian rhythm|regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylinositol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	ARF GTPase activator activity|repressing transcription factor binding|transcription factor binding transcription factor activity	nucleus|cytoplasm|actin cortical patch
YBR012C_d	YBR012C	hom			0.00057059740073062	0.973640326934402	1462	Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p	Unknown	Unknown	Unknown
YGR041W	BUD9	hom	FT	CELL CYCLE|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	0.000569953511918035	0.973670061622172	1463	Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole	cellular bud site selection	molecular_function	plasma membrane|cellular bud neck
YLR214W	FRE1	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|PLASMA MEMBRANE	0.000568566564634514	0.973734110761699	1464	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YJL001W	PRE3	het	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.000567008910984662	0.973806043312455	1465	Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	endopeptidase activity	nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YCR073C	SSK22	hom	FT	SIGNALING|PROTEIN PHOSPHORYLATION	0.000560431176618353	0.974109805871247	1466	MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p	MAPK cascade involved in osmosensory signaling pathway|protein phosphorylation	protein kinase activity|MAP kinase kinase kinase activity	cellular_component
YJL062W	LAS21	hom	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	0.000556977772760163	0.974269287029407	1467	Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity	GPI anchor biosynthetic process	mannose-ethanolamine phosphotransferase activity|transferase activity	integral to endoplasmic reticulum membrane|integral to membrane|integral to plasma membrane
YLL063C	AYT1	hom			0.000550401877297659	0.974572970371295	1468	Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis	secondary metabolic process	trichothecene 3-O-acetyltransferase activity	cellular_component
YLR028C	ADE16	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.000549822965571828	0.974599705439259	1469	Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine	ascospore formation|'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process|aerobic respiration	phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity	cytosol
YAR007C	RFA1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.000543652217750655	0.9749108997348	1470	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination	establishment of protein localization|telomere maintenance via telomerase|telomere maintenance via recombination|nucleotide-excision repair|DNA repair|mitotic recombination|heteroduplex formation|DNA unwinding involved in replication|reciprocal meiotic recombination|DNA replication|double-strand break repair via homologous recombination|protein ubiquitination	double-stranded DNA binding|single-stranded DNA binding|sequence-specific DNA binding	condensed nuclear chromosome|chromosome, telomeric region|DNA replication factor A complex|cytoplasm
YJR078W	BNA2	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	0.000540814953274249	0.975015713488458	1471	Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp	de novo NAD biosynthetic process from tryptophan	tryptophan 2,3-dioxygenase activity|indoleamine 2,3-dioxygenase activity	cytoplasm
YDR330W	UBX5	hom	FT	PROTEOLYSIS|NUCLEUS	0.000538978997264928	0.975115351919804	1472	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p	proteasomal ubiquitin-dependent protein catabolic process	molecular_function	nucleus|cytoplasm
YKL010C	UFD4	hom	FT	PROTEOLYSIS|MITOCHONDRION	0.000533911693514853	0.975352913318465	1473	Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress	protein monoubiquitination|protein polyubiquitination	ubiquitin-protein ligase activity	mitochondrion|cytoplasm
YIL100W_d	YIL100W	hom			0.000520821784361658	0.975939062178581	1474	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A	Unknown	Unknown	Unknown
YDL039C	PRM7	hom			0.000518499867092221	0.976046297880566	1475	Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements	conjugation with cellular fusion	molecular_function	integral to membrane
YML123C	PHO84	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.000509600412889822	0.976460824726936	1476	High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity	phosphate ion transport|manganese ion transport|polyphosphate metabolic process	manganese ion transmembrane transporter activity|inorganic phosphate transmembrane transporter activity	integral to membrane|integral to plasma membrane
YDL218W_p	YDL218W	hom			0.000505231684177755	0.976659085454177	1477	Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin	biological_process	molecular_function	integral to membrane|cytoplasm
YHL001W	RPL14B	hom	FT	TRANSLATION|RIBOSOME	0.000504055749271981	0.976727284513324	1478	Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YJL215C_d	YJL215C	hom			0.000502196535268201	0.976799264964629	1479	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR179C	OKP1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE	0.000496683726671701	0.977053877961912	1480	Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7	attachment of spindle microtubules to kinetochore|chromosome segregation	molecular_function	COMA complex|condensed nuclear chromosome kinetochore
YPR151C	SUE1	hom	FT	PROTEOLYSIS|MITOCHONDRION	0.000485306794868485	0.977579337031034	1481	Mitochondrial protein required for degradation of unstable forms of cytochrome c	protein catabolic process	molecular_function	mitochondrial envelope
YGR008C	STF2	hom	FT	MITOCHONDRION	0.000477787205377615	0.977936517818597	1482	Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress	cellular response to desiccation	molecular_function	cytoplasm
YBR176W	ECM31	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	0.000475329072887936	0.978040179703577	1483	Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate	pantothenate biosynthetic process	3-methyl-2-oxobutanoate hydroxymethyltransferase activity	mitochondrion
YLR205C	HMX1	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	0.000473762985232775	0.978122303392556	1484	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants	response to oxidative stress|cellular iron ion homeostasis|heme catabolic process	heme oxygenase (decyclizing) activity	endoplasmic reticulum|membrane|nuclear outer membrane
YJR109C	CPA2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	0.000455721870773797	0.97894580194582	1485	Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor	arginine biosynthetic process	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carbamoyl-phosphate synthase complex
YCR028C	FEN2	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PLASMA MEMBRANE	0.000451619121665467	0.979135304194793	1486	Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress	pantothenate transmembrane transport|endocytosis	pantothenate transmembrane transporter activity	integral to membrane|plasma membrane
YDL028C	MPS1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	0.000449511329777572	0.979232661642936	1487	Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p	protein phosphorylation|sister chromatid biorientation|spindle assembly|spindle pole body duplication associated with nuclear envelope|mitotic cell cycle spindle assembly checkpoint	protein serine/threonine/tyrosine kinase activity|protein kinase activity	condensed nuclear chromosome kinetochore|spindle pole body
YKR060W	UTP30	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS	0.000443818120601311	0.979495628574931	1488	Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit	ribosomal small subunit biogenesis	molecular_function	nucleolus|nucleus|90S preribosome
YOR298C-A	MBF1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|MITOCHONDRION	0.000441474119422387	0.979606938231716	1489	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress	positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity	mitochondrion|nucleus
YLR199C	PBA1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS	0.00042419243588724	0.980402147572933	1490	Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly	proteasome assembly	molecular_function	cytoplasm
YGR246C	BRF1	het	FT	TRANSLATION|NUCLEUS	0.000423410667736153	0.980447008371094	1491	TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB	DNA-dependent transcriptional open complex formation|transposon integration|RNA polymerase III transcriptional preinitiation complex assembly|negative regulation of protein homodimerization activity	TFIIIC-class transcription factor binding|RNA polymerase III core binding|DNA binding|TFIIIB-type transcription factor activity	transcription factor TFIIIB complex
YBR169C	SSE2	hom			0.000421966678663177	0.980504957895832	1492	Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication	protein folding|protein refolding	adenyl-nucleotide exchange factor activity	cytoplasm
YOL076W	MDM20	hom	FF|FT	MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION	0.000411263759401123	0.981013510116877	1493	Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly	mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization	peptide alpha-N-acetyltransferase activity	NatB complex
YCL022C_d	YCL022C	hom			0.000409345509731742	0.981087950484612	1494	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W	Unknown	Unknown	Unknown
YDL007W	RPT2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS	0.000408449427607679	0.981129342381911	1495	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle	positive regulation of protein catabolic process|proteasome regulatory particle assembly|peptide catabolic process|ubiquitin-dependent protein catabolic process	ATPase activity	proteasome regulatory particle, base subcomplex|nucleus
YML083C	YML083C	hom			0.000407541982013885	0.981171259233266	1496	Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions	biological_process	molecular_function	cellular_component
YOR373W	NUD1	het	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON	0.000406852146418636	0.981203124248486	1497	Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance	meiotic chromosome segregation|spindle pole body separation|exit from mitosis|establishment of spindle localization	structural constituent of cytoskeleton	spindle pole body
YCR013C_d	YCR013C	het			0.000403554786867099	0.981355436912658	1498	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant	Unknown	Unknown	Unknown
YFR004W	RPN11	het	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION|NUCLEUS|MITOCHONDRION	0.000397610230849008	0.981665665732947	1499	Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress	protein deubiquitination|proteasomal ubiquitin-dependent protein catabolic process|peroxisome fission|mitochondrial fission	metallopeptidase activity|ubiquitin-specific protease activity	cytosol|mitochondrion|proteasome storage granule|nucleus|proteasome regulatory particle, lid subcomplex
YBR089W_d	YBR089W	het			0.000388414999525508	0.982054787342519	1500	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30	Unknown	Unknown	Unknown
YPR026W	ATH1	hom	FT	CARBOHYDRATE METABOLISM	0.000376660657262076	0.982597763836732	1501	Acid trehalase required for utilization of extracellular trehalose	trehalose catabolic process|response to stress	alpha,alpha-trehalase activity	fungal-type cell wall|cell wall-bounded periplasmic space|fungal-type vacuole
YLR106C	MDN1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM|NUCLEUS|MITOCHONDRION	0.000371862766167002	0.982819398481807	1502	Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus	ribosomal large subunit assembly|rRNA processing	ATPase activity	nucleoplasm|mitochondrion|nucleus
YOL034W	SMC5	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	0.00036127320951957	0.983313556364917	1503	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair	DNA repair|resolution of recombination intermediates|recombinational repair|rDNA separation	damaged DNA binding|single-stranded DNA binding|ATPase activity	Smc5-Smc6 complex|nucleus
YGL125W	MET13	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	0.000356342782773	0.983536340380281	1504	Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway	methionine biosynthetic process	methylenetetrahydrofolate reductase (NADPH) activity	mitochondrion
YGR074W	SMD1	het	FT	RNA PROCESSING|NUCLEUS	0.000354593582147958	0.983617145126388	1505	Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1; protein abundance increases in response to DNA replication stress	mRNA splicing, via spliceosome	mRNA binding	commitment complex|U1 snRNP|U4/U6 x U5 tri-snRNP complex|U2-type prespliceosome|U5 snRNP
YJR052W	RAD7	hom	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	0.000353921188325335	0.983660399502888	1506	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	damaged DNA binding|ubiquitin-protein ligase activity|DNA-dependent ATPase activity	nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YGR169C	PUS6	hom	FT	RNA PROCESSING|MITOCHONDRION	0.000349005242061478	0.983875300970498	1507	tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|cytoplasm
YDR104C	SPO71	hom	FT	CELL WALL ORG/BIOGENESIS	0.000344396136070655	0.984088221933297	1508	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains	ascospore wall assembly	molecular_function	ascospore wall
YJR108W	ABM1	hom	FT	CYTOSKELETON ORGANIZATION	0.00034138371386537	0.984227383554583	1509	Protein of unknown function, required for normal microtubule organization	microtubule cytoskeleton organization	molecular_function	cellular_component
YDR487C	RIB3	het	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	0.000332033705308712	0.984659318857032	1510	3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration	riboflavin biosynthetic process|aerobic respiration	3,4-dihydroxy-2-butanone-4-phosphate synthase activity	cytosol|mitochondrial intermembrane space
YDR101C	ARX1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS|NUCLEUS|RIBOSOME	0.000322552930709746	0.985099521518302	1511	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex	ribosomal large subunit biogenesis	molecular_function	nucleoplasm|cytosolic large ribosomal subunit|cytoplasm
YBL099W	ATP1	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION	0.000318529935284147	0.985285344416863	1512	Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrial nucleoid|proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, catalytic core
YOR126C	IAH1	hom	FT	KETONE METABOLISM|LIPID METABOLISM	0.000316205075429509	0.985401446367935	1513	Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing	acetate metabolic process	hydrolase activity, acting on ester bonds	cellular_component
YCL035C	GRX1	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.000311118396580712	0.985625543704387	1514	Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	protein glutathionylation|cellular response to oxidative stress	disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity	nucleus|cytoplasm
YGR010W	NMA2	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	0.000310197756348484	0.985676624104669	1515	Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication	NAD biosynthetic process	nicotinamide-nucleotide adenylyltransferase activity	nucleus
YDL011C_d	YDL011C	hom			0.000301646020544638	0.986081858500879	1516	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W	Unknown	Unknown	Unknown
YML129C	COX14	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	0.00029791550802248	0.986235488696182	1517	Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes	mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation	molecular_function	mitochondrial envelope|mitochondrion|integral to membrane|mitochondrial inner membrane|mitochondrial matrix|extrinsic to membrane
YER071C_p	TDA2	hom	FT	SITE OF POLARIZED GROWTH	0.000294417596497624	0.986415350027847	1518	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	mating projection tip|cytoplasm
YKL164C	PIR1	hom	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	0.000294208220866	0.98640675883299	1519	O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication	intracellular protein transport|fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall
YCR102W-A_d	YCR102W-A	hom			0.000292417022635246	0.986489509261173	1520	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML025C	YML6	het	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	0.000272906577548345	0.987392749107776	1521	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YKL174C	TPO5	hom	FT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.000271694133325602	0.98744688318397	1522	Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles	polyamine transport	polyamine transmembrane transporter activity	integral to membrane|Golgi apparatus
YLL015W	BPT1	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	0.00027130150562114	0.987466891241363	1523	ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p	cadmium ion transport|bilirubin transport	bilirubin transmembrane transporter activity|cadmium ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YDR358W	GGA1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|GOLGI APPARATUS	0.000269670123681895	0.987540391118845	1524	Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi	Golgi to vacuole transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to endosome transport	ubiquitin binding	trans-Golgi network
YOL022C	TSR4	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	0.000267452573736733	0.987642840686672	1525	Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2	maturation of SSU-rRNA	molecular_function	cytoplasm
YER171W	RAD3	het	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME	0.000266215294816113	0.987700002369779	1526	5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress	regulation of transposition, RNA-mediated|phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair, DNA incision|regulation of mitotic recombination|transcription from RNA polymerase II promoter	damaged DNA binding|ATP-dependent 5'-3' DNA helicase activity|core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YJR094W-A	RPL43B	hom	FT	TRANSLATION|RIBOSOME	0.000264565392939407	0.987776227130495	1527	Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR054W	YGR054W	hom	FT	TRANSLATION	0.000262088640711365	0.987890652232794	1528	Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A	translational initiation	translation initiation factor activity	cytosolic ribosome|cytosolic small ribosomal subunit|ribosome
YMR139W	RIM11	hom	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION	0.000260407911598317	0.98796830148252	1529	Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress	proteolysis|ascospore formation|protein phosphorylation|response to stress	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YOL075C_p	YOL075C	hom	FT	NUCLEOTIDE METABOLISM	0.000258195040700053	0.988070535718515	1530	Putative ABC transporter	transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YLR223C	IFH1	het	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|GENE SILENCING|NUCLEUS|CHROMOSOME	0.00025092623375603	0.988406354655928	1531	Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing	positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|chromatin silencing at telomere	transcription coactivator activity	nuclear chromatin|nucleolus|nucleus|CURI complex
YML053C_p	YML053C	hom	FT	NUCLEUS	0.000247086503548715	0.988585453204053	1532	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YER065C	ICL1	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	0.000243495065029372	0.988749676830954	1533	Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose	glyoxylate cycle	isocitrate lyase activity	cellular_component
YJL119C_d	YJL119C	hom			0.000241049540389735	0.988862661245182	1534	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR037C	MSN2	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	0.00024056091862841	0.988885235832331	1535	Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|cellular response to methylmercury|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YOR079C	ATX2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	0.000238343567982022	0.988992605264806	1536	Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation	cellular manganese ion homeostasis	manganese ion transmembrane transporter activity	integral to membrane|Golgi membrane
YDL138W	RGT2	hom	FT	SIGNALING|PLASMA MEMBRANE	0.000237902094545857	0.989008075084801	1537	Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication	glucose transport|signal transduction|detection of glucose	glucose transmembrane transporter activity|receptor activity|glucose binding	integral to membrane|plasma membrane
YNL042W	BOP3	hom	FT	NUCLEUS	0.000231084840260377	0.989329406639811	1538	Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury	cellular response to methylmercury	molecular_function	nucleus|cytoplasm
YDR446W	ECM11	hom	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|NUCLEUS	0.000223776316681338	0.989668409000456	1539	Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure	fungal-type cell wall organization|reciprocal meiotic recombination	molecular_function	nucleus
YOR218C_d	YOR218C	het			0.000222142745943861	0.989736171603128	1540	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W	Unknown	Unknown	Unknown
YER067W	RGI1	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS|PLASMA MEMBRANE	0.000221346212771144	0.989772972406226	1541	Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress	energy reserve metabolic process	molecular_function	cell periphery|nucleus|cytoplasm
YGR173W	RBG2	hom	FT	TRANSLATION	0.000215812746704976	0.990028625876676	1542	Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein	cytoplasmic translation	GTP binding	cytoplasm
YPL107W_p	YPL107W	hom	FT	MITOCHONDRION	0.000210692936345636	0.990265168816957	1543	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene	biological_process	molecular_function	mitochondrion
YDR013W	PSF1	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	0.000204334691030919	0.990558930503466	1544	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery	double-strand break repair via break-induced replication|DNA-dependent DNA replication	molecular_function	GINS complex|replication fork protection complex|DNA replication preinitiation complex
YGR121C	MEP1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	0.000203414833607561	0.990601429578942	1545	Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation	nitrogen utilization|ammonium transport	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YLR269C_d	YLR269C	hom			0.000202650211393041	0.990636756527497	1546	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLL046C	RNP1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	0.00020203095768586	0.99067232834969	1547	Ribonucleoprotein that contains two RNA recognition motifs (RRM)	ribosome biogenesis	RNA binding	cytoplasm
YFL021W	GAT1	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	0.000201462254278369	0.990691642361167	1548	Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p	nitrogen catabolite activation of transcription from RNA polymerase II promoter|nitrogen catabolite activation of transcription	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity	cytosol|nucleus
YNL078W	NIS1	hom	FT	CELL CYCLE|NUCLEUS|SITE OF POLARIZED GROWTH	0.000200442857093248	0.990738740446921	1549	Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network	regulation of mitosis	molecular_function	nucleus|cellular bud neck
YML079W_p	YML079W	hom	FT	NUCLEUS	0.00020019175390101	0.990807056577435	1550	Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YLR267W_p	BOP2	hom			0.000199054113617946	0.990802903084533	1551	Protein of unknown function	biological_process	molecular_function	cellular_component
YNL047C	SLM2	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE	0.000194874184657527	0.99102560603794	1552	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol binding	plasma membrane
YPL142C_d	YPL142C	het			0.000189147100355827	0.991273667413662	1553	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit	Unknown	Unknown	Unknown
YIL038C	NOT3	hom	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	0.000187145365860436	0.991353112687947	1554	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation	regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of transcription elongation from RNA polymerase II promoter|protein ubiquitination	ubiquitin-protein ligase activity	CCR4-NOT core complex|cytoplasm
YDL036C	PUS9	hom	FT	RNA PROCESSING|NUCLEUS|MITOCHONDRION	0.000185829573199554	0.991413905378538	1555	Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|nucleus|cytoplasm
YHR180W_d	YHR180W	hom			0.000176959548327654	0.991823722503279	1556	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL092W_p	YIL092W	hom	FT	NUCLEUS	0.000175290279158063	0.991900847118905	1557	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YBL087C	RPL23A	hom	FT	TRANSLATION|RIBOSOME	0.000171028098024419	0.992133195851416	1558	Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YKL066W_d	YKL066W	hom			0.000166845040163101	0.992291040464437	1559	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene YNK1	Unknown	Unknown	Unknown
YNL188W	KAR1	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	0.000164603612631028	0.99240254246725	1560	Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p	karyogamy involved in conjugation with cellular fusion|spindle pole body duplication associated with nuclear envelope	protein binding	half bridge of spindle pole body
YKL117W	SBA1	hom	FT	NUCLEUS	0.000158649336326098	0.992670799342563	1561	Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress	protein folding|positive regulation of telomere maintenance via telomerase|regulation of telomerase activity	chaperone binding	nucleus|cytoplasm
YDR235W	PRP42	het	FT	RNA PROCESSING|NUCLEUS	0.000157722755173579	0.992713603870416	1562	U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats	mRNA splicing, via spliceosome	RNA binding	U1 snRNP|U2-type prespliceosome
YDR037W	KRS1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	0.000157431978572525	0.992725952052153	1563	Lysyl-tRNA synthetase	lysyl-tRNA aminoacylation	lysine-tRNA ligase activity	cytoplasm
YGR001C_p	YGR001C	hom			0.000156258990898281	0.992785531930541	1564	Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae	biological_process	methyltransferase activity	cytoplasm
YJL013C	MAD3	hom	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS	0.000155000604944242	0.992838289139125	1565	Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover	distributive segregation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	mitotic checkpoint complex
YLL051C	FRE6	hom	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	0.000151552154636707	0.992998662693086	1566	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels	intracellular sequestering of iron ion|copper ion import	ferric-chelate reductase activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YDL012C	YDL012C	hom	FT	PLASMA MEMBRANE	0.000143537469936771	0.993367923802091	1567	Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication	biological_process	molecular_function	plasma membrane
YMR028W	TAP42	het	FT	SIGNALING	0.000139252431919054	0.993565907460683	1568	Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits	TOR signaling cascade|positive regulation of transcription from RNA polymerase I promoter	molecular_function	cytosol|extrinsic to membrane
YMR034C_p	YMR034C	hom			0.000136800898858356	0.993679176992706	1569	Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene	biological_process	sterol transporter activity	integral to membrane
YIL147C	SLN1	het	FT	SIGNALING|PROTEIN PHOSPHORYLATION|PLASMA MEMBRANE	0.000125063564884058	0.994222346836105	1570	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators	negative regulation of protein kinase activity|protein autophosphorylation|peptidyl-histidine phosphorylation|osmosensory signaling pathway via two-component system	osmosensor activity|protein histidine kinase activity|histidine phosphotransfer kinase activity	plasma membrane|integral to plasma membrane
YPL152W-A_p	YPL152W-A	hom			0.000124770443732281	0.994235028538445	1571	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YDL237W	AIM6	hom			0.000115448754332074	0.99466572702082	1572	Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene	biological_process	molecular_function	cellular_component
YDR327W_d	YDR327W	het			0.000113693538823951	0.994746825014842	1573	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1	Unknown	Unknown	Unknown
YOR286W	RDL2	hom	FT	MITOCHONDRION	0.00011135940177358	0.994854671589199	1574	Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	thiosulfate sulfurtransferase activity	mitochondrion
YOR364W_d	YOR364W	hom			0.000107227209039927	0.995045595839244	1575	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C	Unknown	Unknown	Unknown
YOL024W_p	YOL024W	hom			0.000105909150970369	0.995106495587467	1576	Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YML023C	NSE5	het	FT	RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	9.07077496139732e-05	0.995809490263673	1577	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair	DNA repair	molecular_function	Smc5-Smc6 complex|nucleus
YAL003W	EFB1	het	FT	TRANSLATION|RIBOSOME	9.02698222811775e-05	0.995829721412784	1578	Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site	translational elongation	translation elongation factor activity|guanyl-nucleotide exchange factor activity	ribosome|eukaryotic translation elongation factor 1 complex
YER089C	PTC2	hom	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS	8.83285799742265e-05	0.995918793451856	1579	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication	endoplasmic reticulum unfolded protein response|inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation|DNA damage checkpoint	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YJR100C	AIM25	hom	FT	MITOCHONDRION	8.69875909487807e-05	0.995983150827646	1580	Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YNL104C	LEU4	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	8.6591356347185e-05	0.995999060885682	1581	Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication	leucine biosynthetic process	2-isopropylmalate synthase activity	mitochondrion|cytoplasm
YGR025W_d	YGR025W	hom			8.20672369688749e-05	0.996209791909637	1582	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL134W	PCL10	hom	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	8.1393115772341e-05	0.996239242885993	1583	Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate	negative regulation of glycogen biosynthetic process|regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YKL179C	COY1	hom	FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	8.00766313653007e-05	0.996300070417767	1584	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function	Golgi vesicle transport	molecular_function	Golgi membrane
YOL015W	IRC10	hom			7.91055637045104e-05	0.996347118632086	1585	Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YGR138C	TPO2	hom	FT	PLASMA MEMBRANE	7.82927173477916e-05	0.996384653424269	1586	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication	spermine transport	spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YOR199W_d	YOR199W	hom			7.32852193927789e-05	0.996616389946033	1587	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL046W	NPC2	hom			7.21925744886404e-05	0.996666837534974	1588	Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes	intracellular sterol transport	molecular_function	fungal-type vacuole lumen|fungal-type vacuole
YKL187C	FAT3	hom	FT	MITOCHONDRION	7.19724859692309e-05	0.996678487960847	1589	Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|integral to membrane
YDL187C_d	YDL187C	hom			7.11949467891685e-05	0.996710444945573	1590	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR289W_p	YOR289W	hom	FT	NUCLEUS	7.01371285591754e-05	0.996764156422252	1591	Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YDR057W	YOS9	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX	6.91376034318932e-05	0.996805503764514	1592	ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family	ER-associated protein catabolic process	oligosaccharide binding	luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum lumen
YGL254W	FZF1	hom	FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS|NUCLEUS	6.74147866879481e-05	0.996885105935052	1593	Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress	positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YCR083W	TRX3	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	6.72543588737065e-05	0.996892518450057	1594	Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p	cellular response to oxidative stress	disulfide oxidoreductase activity	mitochondrion
YKL024C	URA6	het	FT	NUCLEOTIDE METABOLISM|NUCLEUS	6.69136693965944e-05	0.996908259897485	1595	Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)	'de novo' pyrimidine nucleobase biosynthetic process|nucleobase-containing compound metabolic process	uridylate kinase activity|adenylate kinase activity	nucleus|cytoplasm
YLR323C	CWC24	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	6.36301155886392e-05	0.997059975503098	1596	Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p	generation of catalytic spliceosome for first transesterification step|snoRNA splicing	molecular_function	nucleus|U2-type spliceosomal complex
YGR174W-A_p	YGR174W-A	hom			6.21858378707038e-05	0.997129708317374	1597	Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YPR037C	ERV2	hom	FT	OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	6.21619812843611e-05	0.997127810237068	1598	Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER	protein thiol-disulfide exchange	thiol oxidase activity	integral to endoplasmic reticulum membrane
YLR016C	PML1	hom	FT	RNA PROCESSING|RNA LOCALIZATION|NUCLEUS	6.05749587592794e-05	0.99720155552525	1599	Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p	mRNA export from nucleus|mRNA splicing, via spliceosome|maintenance of RNA location	molecular_function	RES complex|nucleus|cytoplasm
YGL152C_d	YGL152C	hom			4.65167148756499e-05	0.997850696576551	1600	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W	Unknown	Unknown	Unknown
YMR204C	INP1	hom	FT	PEROXISOME ORGANIZATION	4.26541589389954e-05	0.998029459347881	1601	Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane	peroxisome inheritance	molecular_function	peroxisome|extrinsic to intraperoxisomal membrane
YGR199W	PMT6	hom	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	3.90232918852556e-05	0.998198004972275	1602	Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases	protein O-linked glycosylation|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane
YGL260W_p	YGL260W	hom			3.85955329623756e-05	0.998216959785601	1603	Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium	biological_process	molecular_function	cellular_component
YLR288C	MEC3	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING|NUCLEUS|CHROMOSOME	3.8199152998102e-05	0.998235008580235	1604	DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1	telomere maintenance via recombination|DNA damage checkpoint|DNA metabolic process|chromatin silencing at telomere	DNA binding	nucleus|checkpoint clamp complex
YGL091C	NBP35	het	FT	RNA PROCESSING|COFACTOR METABOLISM|NUCLEUS	3.60634143399115e-05	0.998333690212436	1605	Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases	iron-sulfur cluster assembly|tRNA wobble uridine modification	4 iron, 4 sulfur cluster binding|ATPase activity|iron ion binding	mitochondrion|nucleus|cytoplasm
YFL027C	GYP8	hom	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	3.50677360586171e-05	0.998379695455803	1606	GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport	vesicle-mediated transport	Rab GTPase activator activity	intracellular
YGR047C	TFC4	het	FT	NUCLEUS	3.45432778305999e-05	0.998403928012679	1607	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102	transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter	RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending	transcription factor TFIIIC complex
YAR042W	SWH1	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	3.41352550712377e-05	0.998422780677636	1608	Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction	endocytosis|maintenance of cell polarity|exocytosis|sterol transport	lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity	nuclear envelope|endoplasmic reticulum|Golgi trans cisterna|early endosome
YIL059C_d	YIL059C	hom			3.38344409151769e-05	0.998436679776642	1609	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W	Unknown	Unknown	Unknown
YPL233W	NSL1	het	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	3.22112112928567e-05	0.998511681006486	1610	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation	chromosome segregation	molecular_function	nuclear MIS12/MIND type complex|kinetochore|spindle pole
YLR056W	ERG3	hom	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	3.05529402473449e-05	0.99858830133681	1611	C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase	ergosterol biosynthetic process	C-5 sterol desaturase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YKR044W	UIP5	hom	FT	ENDOMEMBRANE SYSTEM|NUCLEUS	2.89835394331802e-05	0.998660815434557	1612	Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates	biological_process	molecular_function	nuclear envelope
YLR129W	DIP2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	2.52363333116819e-05	0.998833954977329	1613	Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YPR056W	TFB4	het	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|NUCLEUS|RNA POL II, HOLOENZYME	2.49225293053707e-05	0.998848454284324	1614	Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YLR042C_p	YLR042C	hom			2.3307586474881e-05	0.998923072687088	1615	Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene	biological_process	molecular_function	fungal-type cell wall
YKL097C_d	YKL097C	hom			2.14823385358057e-05	0.999007556249051	1616	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species	Unknown	Unknown	Unknown
YKR063C	LAS1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION	1.64459130616466e-05	0.999240229579253	1617	Protein required for pre-rRNA processing at both ends of ITS2; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S transition of the cell cycle; human ortholog is Las1L; mutants require the SSD1-v allele for viability	maturation of LSU-rRNA|maturation of 5.8S rRNA	molecular_function	mitochondrion|nucleus|preribosome|cytoplasm
YDR384C	ATO3	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION|PLASMA MEMBRANE	1.04449663019512e-05	0.999517822019693	1618	Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters	ammonium transport|nitrogen utilization|transmembrane transport	ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YDR461W	MFA1	hom	FT	SIGNALING|PLASMA MEMBRANE	9.2238865482722e-06	0.99957438238275	1619	Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YLL017W	YLL017W	hom	FT	SIGNALING	8.43510402016667e-06	0.999610255814681	1620	Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication	Ras protein signal transduction	Ras guanyl-nucleotide exchange factor activity	membrane
YHR178W	STB5	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	7.91148736080587e-06	0.99963575994987	1621	Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro	response to xenobiotic stimulus|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YLR401C	DUS3	hom	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS|NUCLEUS	4.29727804795336e-06	0.999801444157988	1622	Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress	tRNA modification	tRNA dihydrouridine synthase activity	nucleus|cytoplasm
YCR101C_p	YCR101C	hom			3.63875472596344e-06	0.999831896313939	1623	Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene	biological_process	molecular_function	integral to membrane|membrane
YOR296W_p	YOR296W	hom			-4.43922178769637e-06	0.999795008009028	1624	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene	biological_process	molecular_function	cytoplasm
YKL151C	YKL151C	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	-5.26646387427817e-06	0.999756771770917	1625	NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	nicotinamide nucleotide metabolic process	ATP-dependent NAD(P)H-hydrate dehydratase activity	cytoplasm
YER030W	CHZ1	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS	-1.12522151327336e-05	0.999480091143681	1626	Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress	chromatin remodeling	histone binding	chromatin assembly complex|nucleus
YBL065W_d	YBL065W	hom			-1.37454277908728e-05	0.999368119990877	1627	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene	Unknown	Unknown	Unknown
YGL243W	TAD1	hom	FT	RNA PROCESSING|NUCLEUS	-1.46049387854308e-05	0.999325178503679	1628	tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala	tRNA modification	tRNA-specific adenosine-37 deaminase activity	nucleus
YOR266W	PNT1	hom	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	-1.5267904654766e-05	0.999294546159886	1629	Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine	protein insertion into mitochondrial membrane from inner side	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YBR210W	ERV15	hom	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION	-1.62173985501936e-05	0.999250786519114	1630	Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|axial cellular bud site selection	molecular_function	integral to membrane|ER to Golgi transport vesicle
YLR144C	ACF2	hom	FT	CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	-1.8607318027394e-05	0.99914024855251	1631	Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress	actin cytoskeleton organization	glucan endo-1,3-beta-D-glucosidase activity	intracellular
YMR140W	SIP5	hom	FT	RESPONSE TO NUTRIENT LEVELS	-1.86857041907536e-05	0.999136626719902	1632	Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress	cellular response to glucose starvation	molecular_function	cytoplasm
YDL083C	RPS16B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	-2.11012474275513e-05	0.999025743666841	1633	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YHL012W_p	YHL012W	hom			-2.13754713763362e-05	0.999012346040778	1634	Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YOR326W	MYO2	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	-2.1932600283286e-05	0.998986755011831	1635	Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication	vacuole inheritance|establishment of mitotic spindle orientation|peroxisome inheritance|budding cell apical bud growth|unidimensional cell growth|mitochondrion inheritance|membrane addition at site of cytokinesis|vesicle transport along actin filament|vesicle-mediated transport|Golgi inheritance	microfilament motor activity|actin filament binding|calmodulin binding	fungal-type vacuole membrane|incipient cellular bud site|filamentous actin|myosin V complex|actin filament bundle|cellular bud neck|cellular bud tip|vesicle|mating projection tip
YDR206W	EBS1	hom	FT	TRANSLATION|NUCLEUS|CHROMOSOME	-2.50192996708039e-05	0.998844155384241	1636	Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors	negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YDR063W	AIM7	hom	FT	CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	-3.25836712390616e-05	0.998494471515251	1637	Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss	actin filament debranching|negative regulation of Arp2/3 complex-mediated actin nucleation	molecular_function	nucleus|actin cortical patch|cytoplasm
YJL007C_d	YJL007C	hom			-3.28875347276799e-05	0.99848133804758	1638	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR060W	ERG25	het	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	-3.77510926453359e-05	0.998255711170459	1639	C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol	ergosterol biosynthetic process	C-4 methylsterol oxidase activity	plasma membrane|endoplasmic reticulum membrane
YHR131C_p	YHR131C	hom			-3.88460237840179e-05	0.99820672636686	1640	Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study	biological_process	molecular_function	cytoplasm
YPR177C_d	YPR177C	het			-3.97209654716432e-05	0.99816496703457	1641	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex	Unknown	Unknown	Unknown
YJR130C	STR2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	-4.09775407432449e-05	0.99810861054763	1642	Cystathionine gamma-synthase, converts cysteine into cystathionine	sulfur compound metabolic process|transsulfuration	cystathionine gamma-synthase activity	nucleus|cytoplasm
YIL158W	AIM20	hom	FT	CELL CYCLE	-4.27278629536224e-05	0.998025759993662	1643	Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress	biological_process	molecular_function	fungal-type vacuole
YJR016C	ILV3	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	-4.46159189205706e-05	0.997938522597465	1644	Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids	branched-chain amino acid biosynthetic process	dihydroxy-acid dehydratase activity	mitochondrion
YJL208C	NUC1	hom	FT	NUCLEUS|MITOCHONDRION	-4.5866482508322e-05	0.997880740472569	1645	Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy	DNA catabolic process|RNA catabolic process|apoptotic process|DNA recombination	ribonuclease activity|endodeoxyribonuclease activity|exodeoxyribonuclease activity	mitochondrion|mitochondrial inner membrane|nucleus
YJR128W_d	YJR128W	hom			-4.77491921356829e-05	0.99779375014471	1646	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2	Unknown	Unknown	Unknown
YBL035C	POL12	het	FT	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME	-4.83201970362923e-05	0.997767366950442	1647	B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation	telomere capping|lagging strand elongation|DNA replication initiation	DNA-directed DNA polymerase activity	nuclear envelope|alpha DNA polymerase:primase complex|nucleus
YOR096W	RPS7A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS|RIBOSOME	-4.90056534956978e-05	0.997735695542596	1648	Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication	cytoplasmic translation|ribosome biogenesis	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YKR021W	ALY1	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	-4.9499151223974e-05	0.997712893559921	1649	Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication	Unknown|regulation of intracellular transport|ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	late endosome|cytoplasm|early endosome
YBR005W	RCR1	hom	FT	VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-4.98019679534718e-05	0.997698901962861	1650	Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication	fungal-type cell wall organization|vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane
YEL066W	HPA3	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	-5.02946328152643e-05	0.997676138465663	1651	D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro	D-amino acid metabolic process	D-amino-acid N-acetyltransferase activity	nucleus|cytoplasm
YOR020W-A_p	YOR020W-A	hom	FT	MITOCHONDRION	-5.04537573137324e-05	0.997668786145339	1652	Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPL026C	SKS1	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION|NUCLEUS	-5.10104240820004e-05	0.997643065453771	1653	Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway	glucose transport|protein phosphorylation|response to glucose stimulus|positive regulation of transcription from RNA polymerase II promoter	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YMR104C	YPK2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION|NUCLEUS	-5.5755040438315e-05	0.997426147002895	1654	Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication	eisosome assembly|protein phosphorylation	protein kinase activity	nucleus|cytoplasm
YML005W	TRM12	hom	FT	RNA PROCESSING	-6.07936026307273e-05	0.997191035807859	1655	S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA	wybutosine biosynthetic process|tRNA methylation	S-adenosylmethionine-dependent methyltransferase activity|transferase activity, transferring alkyl or aryl (other than methyl) groups	cytoplasm
YNL180C	RHO5	hom	FT	SIGNALING|NUCLEUS|PLASMA MEMBRANE	-6.28112523544988e-05	0.997099109262819	1656	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity	Rho protein signal transduction	GTPase activity	endomembrane system|fungal-type vacuole membrane|plasma membrane|nucleus|cytoplasm
YLR272C	YCS4	het	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|GENE SILENCING|NUCLEUS|CHROMOSOME	-6.30679390489833e-05	0.997085950710036	1657	Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation	maintenance of rDNA|meiotic chromosome condensation|mitotic chromosome condensation|tRNA gene clustering|mitotic sister chromatid segregation|chromatin silencing at silent mating-type cassette	molecular_function	nucleolus|nuclear condensin complex
YPL019C	VTC3	hom	FT	MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|ENDOPLASMIC RETICULUM	-6.47744107284705e-05	0.997007103681646	1658	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion	polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane|integral to membrane|vacuolar transporter chaperone complex|endoplasmic reticulum
YJR011C_p	YJR011C	hom			-6.77377343909464e-05	0.996870184242233	1659	Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cellular_component
YML074C	FPR3	hom	FT	CELL CYCLE|CHROMATIN ORGANIZATION|NUCLEUS	-7.11318980567852e-05	0.996713848154519	1660	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p	meiotic recombination checkpoint	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	nucleolus
YER068C-A_d	YER068C-A	hom			-7.46665198083608e-05	0.996551585734625	1661	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL127W	PGM1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	-7.58964221737351e-05	0.996493215123015	1662	Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism	glucose 6-phosphate metabolic process|galactose catabolic process|glucose 1-phosphate metabolic process|UDP-glucose metabolic process|trehalose biosynthetic process|glycogen biosynthetic process	phosphoglucomutase activity	cytoplasm
YMR019W	STB4	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	-7.72478052484927e-05	0.99643077504648	1663	Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;	biological_process	sequence-specific DNA binding|DNA binding	nucleus
YML104C	MDM1	hom	FT	MITOCHONDRION ORGANIZATION|CYTOSKELETON	-7.87571551075919e-05	0.996362664247214	1664	Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)	nuclear migration|mitochondrion inheritance|mitochondrion organization	structural constituent of cytoskeleton|phosphatidylinositol-3-phosphate binding	intermediate filament|integral to membrane|cytoplasm
YJR119C	JHD2	hom	FT	CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEUS	-8.23435031646681e-05	0.996195330705078	1665	JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation	histone demethylation	histone demethylase activity (H3-K4 specific)	nucleus|cytoplasm
YGL251C	HFM1	hom	FT	CELL CYCLE|NUCLEUS	-8.37426878691332e-05	0.996130682086616	1666	Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity	meiosis|synapsis|DNA unwinding involved in replication|reciprocal meiotic recombination	DNA helicase activity	nucleus
YLR226W	BUR2	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION|NUCLEUS	-8.45674425732376e-05	0.996092574726369	1667	Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II	phosphorylation of RNA polymerase II C-terminal domain|positive regulation of histone ubiquitination|transcription, DNA-dependent|positive regulation of histone H3-K4 methylation|mitotic sister chromatid segregation	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YEL004W	YEA4	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-8.50441991350281e-05	0.996072304442066	1668	Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER	fungal-type cell wall chitin biosynthetic process|UDP-N-acetylglucosamine transport|UDP-glucose transport|transmembrane transport	UDP-N-acetylglucosamine transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YDL094C_d	YDL094C	hom			-8.79803384400934e-05	0.995934883751434	1669	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential	Unknown	Unknown	Unknown
YGR148C	RPL24B	hom	FT	TRANSLATION|RIBOSOME	-8.97076557725595e-05	0.995855074064977	1670	Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YLR178C	TFS1	hom	FT	SIGNALING|PROTEOLYSIS	-9.05125101171314e-05	0.995817886255126	1671	Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress	regulation of Ras protein signal transduction|regulation of proteolysis	lipid binding|peptidase inhibitor activity|phospholipid binding	fungal-type vacuole lumen|fungal-type vacuole membrane|cytoplasm
YKL074C	MUD2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	-9.42572515999865e-05	0.995644862852826	1672	Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65	mRNA branch site recognition	pre-mRNA branch point binding	commitment complex
YNL039W	BDP1	het	FT	NUCLEUS	-9.75723342267302e-05	0.995492363958211	1673	Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs	DNA-dependent transcriptional open complex formation|positive regulation of transposon integration|RNA polymerase III transcriptional preinitiation complex assembly	TFIIIC-class transcription factor binding|TFIIIB-type transcription factor activity	transcription factor TFIIIB complex
YKL202W_d	YKL202W	hom			-9.84235103654653e-05	0.995452363753078	1674	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR059W	SEN15	het	FT	RNA PROCESSING|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	-0.000100249588193808	0.995367991174922	1675	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p	tRNA-type intron splice site recognition and cleavage	tRNA-intron endonuclease activity	tRNA-intron endonuclease complex
YGL123W	RPS2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION|NUCLEUS|RIBOSOME	-0.00010328986016444	0.995228229379894	1676	Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5	positive regulation of translational fidelity|rRNA export from nucleus	structural constituent of ribosome|SSU rRNA binding	small-subunit processome|cytosolic small ribosomal subunit
YNL158W	PGA1	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	-0.000108895649884587	0.994968506995347	1677	Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes	GPI anchor biosynthetic process	mannosyltransferase activity	integral to endoplasmic reticulum membrane|nuclear envelope|mannosyltransferase complex
YDR219C	MFB1	hom	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION|UBIQUITIN LIGASE COMPLEX	-0.000109498618631708	0.994940647365464	1678	Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|mitochondrion organization	molecular_function	extrinsic to mitochondrial outer membrane|SCF ubiquitin ligase complex
YJR022W	LSM8	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.000116025758618935	0.994639067121255	1679	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA	mRNA splicing, via spliceosome	RNA binding	U6 snRNP|nucleolus|nucleus|U4/U6 x U5 tri-snRNP complex
YPR108W	RPN7	het	FT	PROTEOLYSIS|NUCLEUS	-0.000116638289412879	0.994613176836017	1680	Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits	ubiquitin-dependent protein catabolic process	structural molecule activity	nucleus|proteasome regulatory particle, lid subcomplex
YOR155C	ISN1	hom	FT	NUCLEOTIDE METABOLISM	-0.000117656834444336	0.994563704944664	1681	Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms	nicotinamide riboside biosynthetic process|inosine salvage|nicotinic acid riboside biosynthetic process	IMP 5'-nucleotidase activity	cellular_component
YKR071C	DRE2	het	FT	COFACTOR METABOLISM|MITOCHONDRION	-0.00012055054805103	0.994430004011108	1682	Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress	iron-sulfur cluster assembly	electron carrier activity	cytosol|cytoplasm|mitochondrial intermembrane space
YML113W	DAT1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	-0.000121582288772101	0.994382333575293	1683	DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability	negative regulation of transcription from RNA polymerase II promoter	AT DNA binding	nucleus
YER159C	BUR6	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	-0.000123737309873621	0.994282763280078	1684	Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity|transcription corepressor activity	nucleus|negative cofactor 2 complex
YMR048W	CSM3	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	-0.000125099777529856	0.99421981205983	1685	Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress	DNA repair|DNA replication checkpoint|meiotic chromosome segregation|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|mitotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	molecular_function	replication fork protection complex|nucleus
YAL034C-B_d	YAL034C-B	het			-0.000129528452747769	0.994015190565513	1686	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YFR042W	KEG1	het	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000130086270424044	0.993989417313122	1687	Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability	chromosome organization|(1->6)-beta-D-glucan biosynthetic process	molecular_function	integral to endoplasmic reticulum membrane|integral to membrane
YDR156W	RPA14	hom	FT	NUCLEUS	-0.000131942170602628	0.993903667863987	1688	RNA polymerase I subunit A14	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size	molecular_function	DNA-directed RNA polymerase I complex
YGR254W	ENO1	hom	FT	MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	-0.000132772271965013	0.9938680587023	1689	Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress	regulation of vacuole fusion, non-autophagic|gluconeogenesis|glycolysis	phosphopyruvate hydratase activity	mitochondrion|phosphopyruvate hydratase complex|plasma membrane|fungal-type vacuole|cytoplasm
YLR117C	CLF1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|NUCLEUS|CHROMOSOME	-0.000133478482788302	0.99383268461478	1690	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins	cis assembly of pre-catalytic spliceosome|DNA replication initiation	DNA replication origin binding|chromatin binding|first spliceosomal transesterification activity|second spliceosomal transesterification activity	chromatin|U2-type post-mRNA release spliceosomal complex|Prp19 complex|U2-type prespliceosome|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YDL174C	DLD1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	-0.000133486325455207	0.993832322254972	1691	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane	cellular carbohydrate metabolic process|aerobic respiration	D-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial inner membrane
YOR261C	RPN8	het	FT	PROTEOLYSIS	-0.00013350344603711	0.993831531221667	1692	Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p	ubiquitin-dependent protein catabolic process	molecular_function	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YBR066C	NRG2	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	-0.000134138021416902	0.993802211529736	1693	Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter by glucose|biofilm formation|pseudohyphal growth|Unknown	sequence-specific DNA binding	nucleus
YDR365C	ESF1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.000135029368535651	0.993766611755918	1694	Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels	rRNA processing	RNA binding	nucleolus|nucleus
YML010W	SPT5	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	-0.000139061591069509	0.993574724980924	1695	Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair	7-methylguanosine mRNA capping|intracellular mRNA localization|mRNA splicing, via spliceosome|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair	core RNA polymerase I binding transcription factor activity|core RNA polymerase II binding transcription factor activity|rRNA binding|RNA polymerase II core binding|RNA polymerase I transcription factor binding|RNA polymerase I core binding	DSIF complex|mitochondrion|rDNA heterochromatin|nucleus
YBR064W_d	YBR064W	hom			-0.000142694370987109	0.993406877873759	1696	Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C	Unknown	Unknown	Unknown
YJR067C	YAE1	het	FT	NUCLEUS	-0.000142890392120546	0.993397821021692	1697	Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species	biological_process	molecular_function	nucleus|cytoplasm
YFR056C_d	YFR056C	hom			-0.000143561999380198	0.993366790457661	1698	Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W	Unknown	Unknown	Unknown
YOR252W	TMA16	hom	FT	NUCLEUS	-0.00014378863181918	0.993356319262197	1699	Protein of unknown function that associates with ribosomes	biological_process	molecular_function	ribosome|nucleus
YOL082W	ATG19	hom	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT	-0.000143890144850417	0.993358571286502	1700	Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles	vesicle organization|ER-associated protein catabolic process|protein processing|protein complex localization|CVT pathway	protein binding, bridging	pre-autophagosomal structure|cytoplasm|CVT complex|extrinsic to membrane
YGR207C	CIR1	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	-0.000145145026015266	0.993293649225266	1701	Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YLR216C	CPR6	hom			-0.000148650654965746	0.993131677406675	1702	Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress	protein folding|protein refolding	unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity	cytoplasm
YPL274W	SAM3	hom	FT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	-0.000149046238394821	0.993113400142745	1703	High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p	spermidine transport|putrescine transport|S-adenosylmethionine transport	S-adenosylmethionine transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity	integral to membrane|plasma membrane
YDR374C_p	YDR374C	hom			-0.000149480678850891	0.993101570439064	1704	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJR095W	SFC1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	-0.000159587675869005	0.992630750966981	1705	Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization	succinate transport|fumarate transport	succinate:fumarate antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YER011W	TIR1	hom			-0.000160339919905824	0.992591596232056	1706	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking	response to stress	structural constituent of cell wall	fungal-type cell wall
YML081C-A	ATP18	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION	-0.000161733995367489	0.992527185738649	1707	Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms	mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YLR410W	VIP1	hom	FT	CYTOSKELETON	-0.000162289211756096	0.99250153307948	1708	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1	inositol phosphate biosynthetic process	inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 4-kinase activity|inositol hexakisphosphate 6-kinase activity	cytoplasm
YKL173W	SNU114	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEOTIDE METABOLISM|NUCLEUS	-0.000164705470536203	0.992389894781451	1709	GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2	assembly of spliceosomal tri-snRNP|spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step	GTP binding|GTPase activity|U5 snRNA binding	U4/U6 x U5 tri-snRNP complex|U5 snRNP
YJR147W	HMS2	hom	FT	NUCLEUS	-0.000166178433241097	0.992321839623376	1710	Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication	pseudohyphal growth	molecular_function	nucleus|cytoplasm
YAL059W	ECM1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|CELL WALL ORG/BIOGENESIS|NUCLEUS	-0.000171348741321002	0.992082956808058	1711	Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm	fungal-type cell wall organization|ribosomal large subunit export from nucleus	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YNL014W	HEF3	hom	FT	TRANSLATION|NUCLEOTIDE METABOLISM|RIBOSOME	-0.000172723629433977	0.992019433218108	1712	Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication	translational elongation	ATPase activity|translation elongation factor activity	cytosolic ribosome
YHR035W_p	YHR035W	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM	-0.000174148519619564	0.991953599449053	1713	Putative protein of unknown function; not an essential gene	biological_process	molecular_function	cellular_component
YER018C	SPC25	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE	-0.000176788528200913	0.991831624078375	1714	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering	microtubule nucleation|chromosome segregation	structural constituent of cytoskeleton	Ndc80 complex|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region
YIR014W_p	YIR014W	hom			-0.000177210354530625	0.991812134605193	1715	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene	biological_process	molecular_function	fungal-type vacuole
YLR250W	SSP120	hom			-0.000177255759369089	0.991810036783894	1716	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YHR003C	YHR003C	hom	FT	MITOCHONDRION	-0.000179926281351644	0.991686651842095	1717	Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YLL055W	YCT1	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE	-0.000180709647461782	0.991650458362985	1718	High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene	cysteine transport	ion transmembrane transporter activity|cysteine transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YDR471W	RPL27B	hom	FT	TRANSLATION|RIBOSOME	-0.00018193341230502	0.991593917392206	1719	Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YJL130C	URA2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|MITOCHONDRION	-0.000183226468572086	0.991534175031653	1720	Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP	glutamine metabolic process|'de novo' pyrimidine nucleobase biosynthetic process|negative regulation of pyrimidine nucleobase metabolic process	aspartate carbamoyltransferase activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	mitochondrion|integral to membrane|cytoplasm
YDR400W	URH1	hom	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|NUCLEUS	-0.000187623567457758	0.991331018670952	1721	Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways	pyrimidine-containing compound salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|pyrimidine nucleoside catabolic process|nicotinate nucleotide salvage	ribosylpyrimidine nucleosidase activity|nicotinic acid riboside hydrolase activity|nicotinamide riboside hydrolase activity|uridine nucleosidase activity	nucleus|cytoplasm
YOR010C	TIR2	hom			-0.000187836354160139	0.991321187436543	1722	Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis	response to stress	molecular_function	fungal-type cell wall
YCL001W-B_p	YCL001W-B	hom			-0.000188516252112753	0.991289774598283	1723	Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YMR297W	PRC1	hom	FT	PROTEOLYSIS|ENDOPLASMIC RETICULUM	-0.000190476926917272	0.991199187019987	1724	Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family	vacuolar protein catabolic process|phytochelatin biosynthetic process	serine-type carboxypeptidase activity	fungal-type vacuole lumen|endoplasmic reticulum|fungal-type vacuole|cytoplasm
YOR304W	ISW2	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS	-0.000192251418777655	0.991117201609478	1725	ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth	negative regulation of transcription from RNA polymerase II promoter by pheromones|nucleosome positioning|termination of RNA polymerase II transcription|negative regulation of antisense RNA transcription|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere	single-stranded DNA binding|DNA translocase activity	chromatin accessibility complex|nucleus
YDL017W	CDC7	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|PROTEIN PHOSPHORYLATION|GENE SILENCING|NUCLEUS	-0.000193100416983428	0.991077976065969	1726	DDK (Dbf4-dependent kinase) catalytic subunit required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p	negative regulation of exit from mitosis|regulation of chromatin silencing at telomere|protein phosphorylation|double-strand break repair via break-induced replication|DNA replication initiation	protein serine/threonine kinase activity	nucleus|Dbf4-dependent protein kinase complex
YPL271W	ATP15	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|MITOCHONDRION	-0.000196791170140399	0.990930530425032	1727	Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YMR309C	NIP1	het	FT	TRANSLATION	-0.000198022227267436	0.990854671487072	1728	eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection	translational initiation	translation initiation factor activity	multi-eIF complex|eukaryotic translation initiation factor 3 complex|cytoplasmic stress granule|cytoplasm
YGL101W_p	YGL101W	hom	FT	NUCLEUS	-0.000198946329191198	0.990807882936246	1729	Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p	biological_process	molecular_function	nucleus|cytoplasm
YMR308C	PSE1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|RNA LOCALIZATION|NUCLEUS	-0.000200722338812486	0.990725827857549	1730	Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p	mRNA export from nucleus|regulation of protein desumoylation|protein import into nucleus|regulation of mitosis	protein transporter activity|nuclear localization sequence binding	integral to membrane|nucleus|cytoplasm
YOL150C_d	YOL150C	hom			-0.000202182535963859	0.990658363999045	1731	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL224C	WHI4	hom			-0.00020455931667819	0.990548552396645	1732	Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication	regulation of cell size	RNA binding	cytoplasm
YNL092W_p	YNL092W	hom			-0.000208077757876389	0.990385994327552	1733	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YLL012W	YEH1	hom	FT	LIPID METABOLISM	-0.000209343664109602	0.990327507367212	1734	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes	sterol metabolic process	sterol esterase activity	integral to membrane|lipid particle
YLR367W	RPS22B	hom	FT	TRANSLATION|RIBOSOME	-0.000212636835951288	0.99017535762914	1735	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YBR280C	SAF1	hom	FT	PROTEOLYSIS|UBIQUITIN LIGASE COMPLEX	-0.000214244456193815	0.990104035270667	1736	F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	SCF ubiquitin ligase complex
YAL043C	PTA1	het	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	-0.000215920846190862	0.990023631527186	1737	Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII	tRNA processing|termination of RNA polymerase II transcription, exosome-dependent|mRNA cleavage|termination of RNA polymerase II transcription, poly(A)-coupled|mRNA polyadenylation	RNA binding	mRNA cleavage factor complex|mRNA cleavage and polyadenylation specificity factor complex
YKL140W	TGL1	hom	FT	LIPID METABOLISM	-0.000216619075110901	0.989991372370692	1738	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes	cellular lipid metabolic process|sterol metabolic process	lipase activity|sterol esterase activity	integral to membrane|lipid particle
YOL045W	PSK2	hom	FT	SIGNALING|TRANSLATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	-0.000217560223584646	0.989950887802193	1739	PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication	regulation of (1->6)-beta-D-glucan biosynthetic process|negative regulation of glycogen biosynthetic process|protein phosphorylation	protein serine/threonine kinase activity	mitochondrion|cytoplasm
YAL054C	ACS1	hom	FT	KETONE METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION	-0.000218744599468717	0.989894677201194	1740	Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions	acetate fermentation|histone acetylation|acetyl-CoA biosynthetic process	acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity	cytosol|mitochondrion|integral to membrane
YDR305C	HNT2	hom	FT	NUCLEUS|MITOCHONDRION	-0.000219419168937762	0.989862004269096	1741	Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins	nucleoside catabolic process	hydrolase activity|nucleoside-triphosphatase activity	mitochondrion|nucleus|cytoplasm
YNL020C	ARK1	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	-0.000220390251467919	0.989818657286433	1742	Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication	regulation of endocytosis|actin filament organization|protein phosphorylation|cytokinesis|actin cortical patch assembly	protein serine/threonine kinase activity|protein kinase activity	mating projection tip|actin cortical patch
YML052W	SUR7	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|MITOCHONDRION|PLASMA MEMBRANE	-0.000220542510115221	0.989810104470227	1743	Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants	endocytosis|ascospore formation	molecular_function	cell cortex|eisosome|mitochondrion|membrane raft|integral to membrane|plasma membrane|actin cortical patch
YGR172C	YIP1	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	-0.000221941088529872	0.989751605614317	1744	Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4	vesicle-mediated transport|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus	molecular_function	integral to membrane|ER to Golgi transport vesicle|integral to Golgi membrane|endoplasmic reticulum membrane
YDR511W	ACN9	hom	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|MITOCHONDRION	-0.00022325510954875	0.989692471417844	1745	Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes	carbon utilization|regulation of gluconeogenesis	molecular_function	mitochondrion|mitochondrial intermembrane space
YPR136C_d	YPR136C	het			-0.00022349957679941	0.989673484414701	1746	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9	Unknown	Unknown	Unknown
YDL086W_p	YDL086W	hom	FT	MITOCHONDRION	-0.000224610374558268	0.989628355047587	1747	Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene	biological_process	carboxymethylenebutenolidase activity	mitochondrion|cytoplasm
YMR247W-A_p	YMR247W-A	hom			-0.000226403051845154	0.989544020419773	1748	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR012W	CLU1	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	-0.000226477210326148	0.989535914452021	1749	eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant	translational initiation|mitochondrion organization	molecular_function	eukaryotic translation initiation factor 3 complex|cytoplasm
YNL312W	RFA2	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	-0.00022979095692981	0.989382816059181	1750	Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress	establishment of protein localization|telomere maintenance via telomerase|telomere maintenance via recombination|nucleotide-excision repair|DNA repair|mitotic recombination|heteroduplex formation|DNA unwinding involved in replication|reciprocal meiotic recombination|double-strand break repair via homologous recombination|DNA replication|protein ubiquitination	double-stranded DNA binding|single-stranded DNA binding|sequence-specific DNA binding	condensed nuclear chromosome|chromosome, telomeric region|DNA replication factor A complex
YNR021W_p	YNR021W	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000230520890100589	0.989350680524773	1751	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YHL043W	ECM34	hom	FT	CELL WALL ORG/BIOGENESIS	-0.000230661006932399	0.989342618947227	1752	Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	fungal-type cell wall organization	molecular_function	cellular_component
YBR149W	ARA1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM	-0.000232430167718176	0.989260882171974	1753	NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product	cellular carbohydrate metabolic process	alditol:NADP+ 1-oxidoreductase activity|D-arabinose 1-dehydrogenase [NAD(P)+] activity	cytosol
YLR118C	YLR118C	hom	FT	KETONE METABOLISM|LIPID METABOLISM|NUCLEUS	-0.000236099607163201	0.989091351221218	1754	Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS	protein deacylation	palmitoyl-(protein) hydrolase activity	nucleus|cytoplasm
YDR044W	HEM13	het	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	-0.000236483951337842	0.989078482352721	1755	Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)	heme biosynthetic process	coproporphyrinogen oxidase activity	cytosol
YMR229C	RRP5	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.000238286418206305	0.988991960626274	1756	RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	poly(U) RNA binding	small-subunit processome|nucleolus|90S preribosome
YOR092W	ECM3	hom	FT	CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000238287327869985	0.989026447797328	1757	Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication	fungal-type cell wall organization	ATPase activity	integral to membrane|endoplasmic reticulum
YOR093C_p	YOR093C	hom	FT	NUCLEUS	-0.000239729847856442	0.988925283248554	1758	Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents	biological_process	molecular_function	integral to membrane
YDR055W	PST1	hom	FT	CELL WALL ORG/BIOGENESIS|PLASMA MEMBRANE	-0.000240126402850322	0.988921863941975	1759	Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1	fungal-type cell wall organization	molecular_function	fungal-type cell wall|plasma membrane
YGR211W	ZPR1	het	FT	CELL CYCLE|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	-0.000243381370875724	0.988763315207956	1760	Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress	regulation of mitotic cell cycle|cellular response to starvation	protein binding	nucleus|cytoplasm
YDL123W	SNA4	hom			-0.000244972630101783	0.9886814127233	1761	Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated	biological_process	molecular_function	fungal-type vacuole lumen|fungal-type vacuole membrane
YPL027W	SMA1	hom	FT	MEMBRANE ORGANIZATION	-0.000247309593641404	0.988573444226013	1762	Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p	ascospore-type prospore membrane assembly	molecular_function	prospore membrane
YML051W	GAL80	hom	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEUS	-0.000247438062079887	0.988569213518706	1763	Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding	negative regulation of kinase activity|galactose metabolic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity	RNA polymerase II activating transcription factor binding|kinase inhibitor activity	nucleus|cytoplasm
YNL023C	FAP1	hom	FT	NUCLEUS	-0.000251258621577096	0.988390998290758	1764	Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1	biological_process	sequence-specific DNA binding transcription factor activity	cytoplasm
YKR082W	NUP133	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	-0.000251488710338225	0.988380368159397	1765	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133	poly(A)+ mRNA export from nucleus|double-strand break repair|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|tRNA export from nucleus|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore outer ring
YDL054C	MCH1	hom			-0.000252283471244043	0.98834538805961	1766	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|membrane
YOL080C	REX4	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.000264055236299721	0.987799796171561	1767	Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly	ribosomal large subunit assembly|rRNA processing	3'-5' exonuclease activity	nucleolus|nucleus
YLR298C	YHC1	het	FT	RNA PROCESSING|NUCLEUS	-0.00026647202513498	0.987688141548974	1768	Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site	mRNA splicing, via spliceosome	mRNA binding	commitment complex|U1 snRNP|U2-type prespliceosome
YCR054C	CTR86	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM	-0.000267679341610001	0.98763420810734	1769	Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	cytoplasm
YLR459W	GAB1	het	FT	CELL CYCLE|LIPID METABOLISM|CELL DIVISION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000270591831631211	0.987497808787154	1770	GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI	attachment of GPI anchor to protein	GPI-anchor transamidase activity	integral to membrane|GPI-anchor transamidase complex
YBR115C	LYS2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	-0.000270824495426415	0.987487059870727	1771	Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p	lysine biosynthetic process via aminoadipic acid	L-aminoadipate-semialdehyde dehydrogenase activity	cytoplasm
YOL125W	TRM13	hom	FT	RNA PROCESSING|NUCLEUS	-0.000279875989910059	0.987068888477942	1772	2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases	tRNA methylation	tRNA methyltransferase activity	nucleus|cytoplasm
YIL089W	YIL089W	hom	FT	ENDOPLASMIC RETICULUM	-0.000284463819301226	0.986858895560407	1773	Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking	biological_process	molecular_function	fungal-type vacuole lumen|integral to membrane|endoplasmic reticulum
YPL069C	BTS1	hom	FF|FT	PROTEIN LOCALIZATION|LIPID METABOLISM|MITOCHONDRION	-0.000288344794145359	0.986693538801362	1774	Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic	terpenoid biosynthetic process	farnesyltranstransferase activity	mitochondrion
YNL067W-B_p	YNL067W-B	hom			-0.000290536743511049	0.9865763752372	1775	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBL040C	ERD2	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000290616778984651	0.98658269044038	1776	HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins	protein retention in ER lumen|ER to Golgi vesicle-mediated transport	HDEL sequence binding	integral to endoplasmic reticulum membrane|integral to membrane
YKR105C_p	VBA5	hom			-0.000291930613747426	0.986511980581234	1777	Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p	biological_process	molecular_function	integral to membrane
YLR385C	SWC7	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	-0.000293295570195751	0.986448921782814	1778	Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin	chromatin remodeling	molecular_function	Swr1 complex|nucleus
YMR177W	MMT1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	-0.000294057988302336	0.986413699326074	1779	Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p	cellular iron ion homeostasis	molecular_function	mitochondrion|integral to membrane
YKL171W	NNK1	hom	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION	-0.000294809268026258	0.986378991470101	1780	Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm	proteolysis|protein phosphorylation	protein kinase activity	cytoplasm
YCL058C	FYV5	hom	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS	-0.000298950664741205	0.98618972573048	1781	Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis	pheromone-dependent signal transduction involved in conjugation with cellular fusion|cellular ion homeostasis	molecular_function	integral to membrane
YEL016C	NPP2	hom	FT	NUCLEOTIDE METABOLISM	-0.000301902417099512	0.986057541154957	1782	Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication	nucleoside triphosphate metabolic process	nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity	cellular_component
YOL048C	RRT8	hom			-0.000304643185908897	0.985924683452457	1783	Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|lipid particle
YLR326W_p	YLR326W	hom			-0.000306797218502664	0.985825171909873	1784	Putative protein of unknown function, predicted to be palmitoylated	biological_process	molecular_function	cellular_component
YDR434W	GPI17	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000308735956490179	0.985735606690456	1785	Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog	attachment of GPI anchor to protein	GPI-anchor transamidase activity	integral to membrane|endoplasmic reticulum|GPI-anchor transamidase complex
YGL202W	ARO8	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	-0.000309297254922595	0.985709676032139	1786	Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis	aromatic amino acid family metabolic process	aromatic-amino-acid:2-oxoglutarate aminotransferase activity|2-aminoadipate transaminase activity	cytoplasm
YLR314C	CDC3	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	-0.000314328217493698	0.985485921025334	1787	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells	septin ring disassembly|maintenance of cell polarity|cell cycle cytokinesis|septin ring assembly	structural molecule activity|GTP binding|1-phosphatidylinositol binding	mating projection base|septin filament array|cellular bud neck septin ring|septin complex|prospore membrane|ascospore wall
YDR309C	GIC2	hom	FT	CELL CYCLE|SIGNALING|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON	-0.000314647202042191	0.985475531339991	1788	Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region	regulation of exit from mitosis|establishment of cell polarity|axial cellular bud site selection|Rho protein signal transduction	Rho GTPase binding|Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding	incipient cellular bud site|actin cap|plasma membrane|mating projection tip|cellular bud tip
YHR043C	DOG2	hom	FT	CARBOHYDRATE METABOLISM|NUCLEUS	-0.000315069260827499	0.985443023908888	1789	2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, paralogous to DOG1, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed	glucose metabolic process	2-deoxyglucose-6-phosphatase activity	nucleus|cytoplasm
YLR283W_p	YLR283W	hom	FT	MITOCHONDRION	-0.000315969062311573	0.985412341405784	1790	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene	biological_process	molecular_function	mitochondrion
YDL219W	DTD1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	-0.000316858336875014	0.985360373433842	1791	D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes	Unknown	D-leucyl-tRNA(Leu) deacylase activity|D-tyrosyl-tRNA(Tyr) deacylase activity	cytoplasm
YKL131W_d	YKL131W	hom			-0.000317374613257929	0.985336522890322	1792	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL037C	BSC1	hom			-0.000321100792364029	0.985164384092869	1793	Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression	biological_process	molecular_function	cellular_component
YMR103C_d	YMR103C	hom			-0.000321957343650926	0.985124813975135	1794	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML084W_d	YML084W	hom			-0.000322078163999768	0.985119232437892	1795	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBL044W_p	YBL044W	hom			-0.000322201600048378	0.985124630627849	1796	Putative protein of unknown function; YBL044W is not an essential protein	biological_process	molecular_function	cellular_component
YOL063C	CRT10	hom	FT	TRANSCRIPTION FROM RNA POL II	-0.000323258987185987	0.985064681991554	1797	Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat	regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YDR411C	DFM1	hom	FT	SIGNALING|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX	-0.000327679050869546	0.984862746257475	1798	Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p	endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process	molecular_function	Doa10p ubiquitin ligase complex|integral to membrane|endoplasmic reticulum|Hrd1p ubiquitin ligase ERAD-L complex
YLR222C	UTP13	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.000328713002495762	0.984812723951799	1799	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YML100W-A_p	YML100W-A	hom			-0.000332608900803388	0.984632746852981	1800	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YDR134C	YDR134C	hom			-0.00033382950735598	0.984578658708215	1801	Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication	biological_process	molecular_function	fungal-type cell wall
YGR193C	PDX1	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	-0.000333914275905869	0.984574743290528	1802	Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core	acetyl-CoA biosynthetic process from pyruvate	structural molecule activity	mitochondrion|mitochondrial pyruvate dehydrogenase complex
YER172C	BRR2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	-0.000338324004987044	0.984368730118375	1803	RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	ATP-dependent RNA helicase activity	U4/U6 x U5 tri-snRNP complex|U5 snRNP
YPL230W	USV1	hom	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	-0.000339408299380349	0.984318639908783	1804	Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to salt stress	sequence-specific DNA binding	nucleus
YGR237C_p	YGR237C	hom			-0.00034507341355242	0.984066444428045	1805	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YBR129C	OPY1	hom	FT	MITOCHONDRION	-0.000351553898248253	0.983757564458762	1806	Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YBR162C	TOS1	hom			-0.000353731149322332	0.98367404897875	1807	Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C	biological_process	molecular_function	fungal-type cell wall|fungal-type vacuole
YOR161C-C_p	YOR161C-C	hom			-0.000354184550027202	0.983636040488441	1808	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YJR092W	BUD4	hom	FT	CELL CYCLE|CELL DIVISION|SITE OF POLARIZED GROWTH|CYTOSKELETON	-0.000357127092529198	0.983500109056095	1809	Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p	cellular bud site selection|axial cellular bud site selection	GTP binding	cellular bud neck contractile ring
YML009C	MRPL39	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	-0.000357677196820899	0.983474696913947	1810	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOL086W-A	MHF1	hom	FT	RESPONSE TO DNA DAMAGE	-0.000358397947386308	0.983441401769477	1811	Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1	response to DNA damage stimulus	molecular_function	cellular_component
YPR165W	RHO1	het	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|CYTOSKELETON ORGANIZATION|MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	-0.000358436353561848	0.983439627593164	1812	GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)	regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process|regulation of fungal-type cell wall organization|positive regulation of endocytosis|budding cell bud growth|small GTPase mediated signal transduction|regulation of protein localization|positive regulation of protein kinase C signaling cascade|actin cytoskeleton organization|regulation of vacuole fusion, non-autophagic|actin cytoskeleton reorganization|regulation of exocyst localization|regulation of cell size	GTPase activity|signal transducer activity	incipient cellular bud site|mitochondrion|Golgi apparatus|peroxisome|cellular bud neck|cellular bud tip|mitochondrial outer membrane|1,3-beta-D-glucan synthase complex|plasma membrane|mating projection tip
YMR114C	YMR114C	hom	FT	NUCLEUS	-0.000360810417349471	0.98337225821657	1813	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YHR019C	DED81	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	-0.000362370367570342	0.98326538515785	1814	Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA	asparaginyl-tRNA aminoacylation	asparagine-tRNA ligase activity	cytosol
YNL301C	RPL18B	hom	FT	TRANSLATION|RIBOSOME	-0.000363875174779346	0.983188381648289	1815	Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR009W	GAL3	hom	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|NUCLEUS	-0.000370197308309162	0.982906535221528	1816	Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication	maintenance of protein location|galactose metabolic process|positive regulation of transcription from RNA polymerase II promoter by galactose	protein binding	nucleus|cytoplasm
YMR291W	TDA1	hom	FT	PROTEIN PHOSPHORYLATION|NUCLEUS	-0.000371579547871927	0.98283248156032	1817	Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress	protein phosphorylation	protein kinase activity	nucleus|cytoplasm
YJL167W	ERG20	het	FT	LIPID METABOLISM|ENDOPLASMIC RETICULUM	-0.000373947401137146	0.982738560522997	1818	Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis	farnesyl diphosphate biosynthetic process|ergosterol biosynthetic process|isoprenoid biosynthetic process	dimethylallyltranstransferase activity|geranyltranstransferase activity	endoplasmic reticulum|cytoplasm
YJL200C	ACO2	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	-0.00037553401511355	0.982660156996788	1819	Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol	biological_process	aconitate hydratase activity	mitochondrion
YCR057C	PWP2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION|NUCLEUS	-0.000384534817593085	0.982247273479069	1820	Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|establishment of cell polarity|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytokinesis	snoRNA binding	small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|cytoplasm|90S preribosome
YJL035C	TAD2	het	FT	RNA PROCESSING|NUCLEUS	-0.000388738622679326	0.982039838109842	1821	Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs	tRNA modification	tRNA-specific adenosine deaminase activity	nucleus|cytoplasm
YOR159C	SME1	het	FT	RNA PROCESSING|NUCLEUS	-0.000389159722449967	0.982020386116614	1822	Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E	mRNA splicing, via spliceosome	molecular_function	U1 snRNP|U2-type prespliceosome|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YGR213C	RTA1	hom	FT	PLASMA MEMBRANE	-0.000391486347739967	0.981912911780836	1823	Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein	biological_process	molecular_function	integral to membrane|plasma membrane
YLL011W	SOF1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.00039400575584643	0.981796532554295	1824	Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus|90S preribosome
YMR210W	YMR210W	hom	FT	KETONE METABOLISM|LIPID METABOLISM	-0.000396033574144223	0.981702861657504	1825	Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification	medium-chain fatty acid biosynthetic process	transferase activity, transferring acyl groups	cellular_component
YPR167C	MET16	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	-0.000397716995997589	0.981625099637836	1826	3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process	phosphoadenylyl-sulfate reductase (thioredoxin) activity	cytoplasm
YCL076W_d	YCL076W	hom			-0.000398007687243375	0.981611671804155	1827	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR172W	HOT1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	-0.000398516831861148	0.98160188154567	1828	Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p	cellular hyperosmotic salinity response|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YDR082W	STN1	het	FT	NUCLEUS|CHROMOSOME	-0.00039855482519469	0.981594634673367	1829	Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping	telomere capping|negative regulation of telomere maintenance via telomerase	single-stranded telomeric DNA binding	nuclear telomere cap complex
YLL028W	TPO1	hom	FT	PLASMA MEMBRANE	-0.000399347881274906	0.981549764597724	1830	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane	spermidine transport|putrescine transport|spermine transport	spermidine transmembrane transporter activity|spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|cellular bud membrane|plasma membrane
YOR100C	CRC1	hom	FT	KETONE METABOLISM|LIPID METABOLISM|MITOCHONDRION	-0.000399611204488268	0.981537600995541	1831	Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation	fatty acid metabolic process	carnitine:acyl carnitine antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YAR019C	CDC15	het	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	-0.000399628499510203	0.981536802092458	1832	Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress	regulation of exit from mitosis|protein phosphorylation|meiotic anaphase II|cytokinesis	protein kinase activity	spindle pole body|cellular bud neck
YPL190C	NAB3	het	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|NUCLEUS	-0.000399776842891655	0.981529949717705	1833	RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3&#8242; end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing	nuclear mRNA surveillance|mRNA 3'-end processing|antisense RNA transcript catabolic process|CUT catabolic process|termination of RNA polymerase II transcription, exosome-dependent|tRNA 3'-end processing|snRNA 3'-end processing|snoRNA 3'-end processing	RNA binding|transcription regulatory region RNA binding	Nrd1 complex|nucleus
YDL114W_p	YDL114W	hom	FT	OXIDATION-REDUCTION PROCESS	-0.000404688695577543	0.981314210959468	1834	Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene	biological_process	molecular_function	integral to membrane
YNL073W	MSK1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION|MITOCHONDRION	-0.000405792329464695	0.98125207957042	1835	Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)	tRNA import into mitochondrion|lysyl-tRNA aminoacylation|mitochondrial lysyl-tRNA aminoacylation|mitochondrial translation	lysine-tRNA ligase activity	mitochondrion
YGR112W	SHY1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	-0.000406790800452404	0.981205957954318	1836	Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome	mitochondrial respiratory chain complex IV assembly|aerobic respiration	unfolded protein binding	mitochondrion|integral to membrane|mitochondrial inner membrane
YMR195W	ICY1	hom			-0.000407408049772941	0.981177445854116	1837	Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation	biological_process	molecular_function	fungal-type vacuole membrane
YPL246C	RBD2	hom	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	-0.000409744132711249	0.981069537276341	1838	Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p	biological_process	molecular_function	COPI-coated vesicle|integral to membrane|Golgi apparatus
YJL131C	AIM23	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	-0.000410252395796785	0.981046059582623	1839	Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss	positive regulation of mitochondrial translational initiation	ribosome binding|translation initiation factor activity	mitochondrion
YDR478W	SNM1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.000410462835928963	0.981036338934658	1840	Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP	mRNA cleavage|rRNA processing	ribonuclease MRP activity|RNA binding	ribonuclease MRP complex
YBR079C	RPG1	het	FT	TRANSLATION	-0.000413165104052931	0.980911516049744	1841	eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation	translation reinitiation|translational initiation	translation initiation factor activity	incipient cellular bud site|eukaryotic translation initiation factor 3 complex|cytoplasmic stress granule|cytoplasm
YPR103W	PRE2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	-0.000414255771062209	0.980861136206135	1842	Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome	proteasomal ubiquitin-dependent protein catabolic process|proteasome core complex assembly|proteasomal ubiquitin-independent protein catabolic process	endopeptidase activity	nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YDR512C	EMI1	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|MITOCHONDRION ORGANIZATION	-0.000414521965447126	0.980848840226939	1843	Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs	ascospore formation|mitochondrial respiratory chain complex assembly|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YJL077W-B_p	YJL077W-B	hom			-0.000414723950665795	0.980839510183258	1844	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YDR350C	ATP22	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	-0.000419624547737832	0.980621815861199	1845	Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane	proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrial inner membrane
YKL107W_p	YKL107W	hom	FT	OXIDATION-REDUCTION PROCESS	-0.000420904052438154	0.980554041955153	1846	Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein	biological_process	molecular_function	cellular_component
YKL197C	PEX1	hom	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION	-0.000420929637804587	0.980552860133611	1847	AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis	protein import into peroxisome matrix, receptor recycling	ATPase activity|protein heterodimerization activity	peroxisomal membrane|peroxisome
YOR122C	PFY1	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE|CYTOSKELETON	-0.000421243986740609	0.980538339948568	1848	Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress	positive regulation of formin-nucleated actin cable assembly|sequestering of actin monomers|intracellular transport	actin monomer binding|phosphatidylinositol-4,5-bisphosphate binding|proline-rich region binding	cytosol|extrinsic to plasma membrane
YLR312C_p	YLR312C	hom			-0.00042243235869616	0.980483447564983	1849	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJL002C	OST1	het	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000423683681818377	0.980425647488296	1850	Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins	protein N-linked glycosylation via asparagine|protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex
YOR271C_p	FSF1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	-0.000424446151340018	0.980399199619002	1851	Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis	biological_process	molecular_function	mitochondrion|integral to membrane
YOL060C	MAM3	hom	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	-0.000425844224793304	0.98032584972651	1852	Protein required for normal mitochondrial morphology, has similarity to hemolysins	cellular manganese ion homeostasis|mitochondrion organization	molecular_function	fungal-type vacuole membrane|integral to membrane
YMR215W	GAS3	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	-0.00043006742211035	0.980130776672493	1853	Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation	biological_process	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane|plasma membrane
YDR109C_p	YDR109C	hom	FT	CARBOHYDRATE METABOLISM	-0.000432454426276846	0.980035416400031	1854	Putative kinase	biological_process	molecular_function	cellular_component
YJL198W	PHO90	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	-0.000434326432708852	0.979934050575535	1855	Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication	phosphate ion transport	phosphate ion transmembrane transporter activity	integral to membrane|membrane
YBR054W	YRO2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	-0.000438035099926834	0.979762746142249	1856	Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane|cellular bud
YBL076C	ILS1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	-0.000438611771276272	0.979739130486326	1857	Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A	cytoplasmic translation|isoleucyl-tRNA aminoacylation	isoleucine-tRNA ligase activity	cytosol
YOR028C	CIN5	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	-0.000438791587616521	0.979727803866898	1858	Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication	hyperosmotic salinity response|response to drug|hyperosmotic response|regulation of transcription from RNA polymerase II promoter	repressing transcription factor binding|sequence-specific DNA binding	nucleus|cytoplasm
YNL303W_d	YNL303W	hom			-0.000439621253523003	0.979713716816255	1859	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR002W	MPP10	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.000442034507970823	0.97957801335002	1860	Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|Mpp10 complex|nucleolus|nucleus|90S preribosome
YHR164C	DNA2	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	-0.000442603756439134	0.979551719832864	1861	Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress	DNA repair|lagging strand elongation|meiotic DNA double-strand break processing|DNA strand renaturation|replicative cell aging|telomere maintenance|DNA-dependent DNA replication	ATP-dependent DNA helicase activity|single-stranded DNA specific endodeoxyribonuclease activity|5'-flap endonuclease activity	nuclear chromosome, telomeric region|nucleus|cytoplasm
YKL206C	ADD66	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS	-0.000442979519315289	0.979534363403721	1862	Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly	proteasome assembly	molecular_function	cytosol|cytoplasm
YJL145W	SFH5	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000443752727292315	0.979498649077302	1863	Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress	Golgi to plasma membrane protein transport|phosphatidylinositol metabolic process|Unknown|regulation of exocytosis|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cell periphery|cytosol|plasma membrane|cortical endoplasmic reticulum
YPL189W	GUP2	hom			-0.000444023347465265	0.979486149193727	1864	Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog	glycerol transport	O-acyltransferase activity	integral to membrane|membrane
YLR049C_p	YLR049C	hom			-0.000445794386256494	0.979404345443539	1865	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR003W	YSP3	hom	FT	PROTEOLYSIS	-0.000446496788782454	0.979371901741601	1866	Putative precursor to the subtilisin-like protease III	protein catabolic process	peptidase activity	cellular_component
YOL047C_p	YOL047C	hom			-0.000447961589428077	0.979304243274167	1867	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	integral to membrane|cytoplasm
YOR119C	RIO1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS	-0.000449200408003065	0.979247022930663	1868	Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA	regulation of exit from mitosis|S phase of mitotic cell cycle|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	protein kinase activity	nucleus|cytoplasm
YOR376W-A_p	YOR376W-A	hom			-0.000449864641417608	0.979216342401259	1869	Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YKL196C	YKT6	het	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|MITOCHONDRION|GOLGI APPARATUS|PLASMA MEMBRANE	-0.000450839137727255	0.979171331076809	1870	Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus	intra-Golgi vesicle-mediated transport|vacuole fusion, non-autophagic|vesicle fusion	palmitoyltransferase activity|SNAP receptor activity	SNARE complex|endosome|mitochondrion|Golgi apparatus|fungal-type vacuole|membrane
YML100W	TSL1	hom	FT	CARBOHYDRATE METABOLISM	-0.000450880660201082	0.979184944439408	1871	Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication	trehalose biosynthetic process|response to stress	enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YOR083W	WHI5	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS	-0.00045130291148464	0.979149909704372	1872	Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1	negative regulation of transcription involved in G1/S phase of mitotic cell cycle|regulation of cell size	RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	SBF transcription complex|nucleus|cytoplasm
YCL048W	SPS22	hom	FT	CELL WALL ORG/BIOGENESIS|PLASMA MEMBRANE	-0.000453062532314755	0.979068634235249	1873	Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall	ascospore wall assembly|fungal-type cell wall organization	molecular_function	plasma membrane
YLR193C	UPS1	hom	FT	LIPID METABOLISM|MITOCHONDRION	-0.000456288402338764	0.978919634461299	1874	Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI	Unknown|cardiolipin metabolic process	molecular_function	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial intermembrane space
YDL129W	YDL129W	hom	FT	NUCLEUS	-0.000457541568957904	0.978861752121672	1875	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YGR117C_p	YGR117C	hom			-0.000457556643349911	0.978861055853342	1876	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YDR428C	BNA7	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	-0.000461902365947212	0.978669877704479	1877	Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine	NAD biosynthetic process	arylformamidase activity	cellular_component
YJR099W	YUH1	hom	FT	PROTEOLYSIS	-0.000464479237749351	0.978541311118571	1878	Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p	protein deubiquitination	ubiquitin-specific protease activity	cytoplasm
YCR022C_d	YCR022C	hom			-0.000466434132895672	0.978451017929389	1879	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene	Unknown	Unknown	Unknown
YLR164W	SHH4	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	-0.000466498236386924	0.978448057105863	1880	Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner	biological_process	molecular_function	mitochondrion|mitochondrial inner membrane
YLR394W	CST9	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	-0.000466904846833902	0.978429276516685	1881	SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate	synaptonemal complex assembly|protein sumoylation|synapsis|reciprocal meiotic recombination	SUMO ligase activity	condensed nuclear chromosome|nuclear chromosome
YIL006W	YIA6	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	-0.000467460201340231	0.978413285460826	1882	Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs	transport|mitochondrial pyruvate transport|NAD transmembrane transport	pyruvate secondary active transmembrane transporter activity|transporter activity|NAD transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YGR085C	RPL11B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	-0.00046892210267249	0.978358719913036	1883	Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR046C	BAP3	hom	FT	MITOCHONDRION|PLASMA MEMBRANE	-0.000469864503447384	0.978292575778447	1884	Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YGL250W	RMR1	hom	FT	CELL CYCLE|NUCLEUS	-0.00047110082096852	0.978235472883704	1885	Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus	meiotic gene conversion|reciprocal meiotic recombination	molecular_function	nucleus|cytoplasm
YER053C	PIC2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|MITOCHONDRION	-0.000473057941880774	0.978145077830969	1886	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature	phosphate ion transport|transmembrane transport	inorganic phosphate transmembrane transporter activity	mitochondrion|integral to membrane
YGR042W	YGR042W	hom	FT	NUCLEUS	-0.000473171295120944	0.978169188425931	1887	Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YJR151W-A_p	YJR151W-A	hom			-0.00047414316117961	0.978108018698563	1888	Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YMR031C	EIS1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION|PLASMA MEMBRANE	-0.000474609335198863	0.978083229980484	1889	Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress	eisosome assembly	molecular_function	eisosome|mitochondrion|membrane raft|cytoplasm
YLR083C	EMP70	hom	FT	VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	-0.000476689057367855	0.977977365443914	1890	Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments	cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|endosomal transport|invasive growth in response to glucose limitation	molecular_function	endosome|fungal-type vacuole membrane|integral to membrane
YLR127C	APC2	het	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	-0.000477052112682665	0.977970454644899	1891	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p	mitotic metaphase/anaphase transition|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|exit from mitosis|cyclin catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YBR121C	GRS1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	-0.000479488120053215	0.977848084214514	1892	Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication	mitochondrial glycyl-tRNA aminoacylation|glycyl-tRNA aminoacylation|DNA-dependent transcription, termination	glycine-tRNA ligase activity	mitochondrion|cytoplasm
YDR286C_p	YDR286C	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	-0.000482178345539891	0.97772383043271	1893	Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site	biological_process	molecular_function	cellular_component
YDR279W	RNH202	hom	FT	NUCLEUS	-0.000482274167369596	0.977719404707796	1894	Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome	RNA catabolic process|DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus
YKL124W	SSH4	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	-0.00048242716919745	0.977712338010495	1895	Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|vesicle-mediated transport	molecular_function	fungal-type vacuole
YER066W_p	RRT13	hom			-0.000483459857269183	0.977664641279611	1896	Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription	biological_process	molecular_function	cellular_component
YDL043C	PRP11	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	-0.000485456540273386	0.977572420772182	1897	Subunit of the SF3a splicing factor complex, required for spliceosome assembly	spliceosomal complex assembly	RNA binding	U2 snRNP|U2-type prespliceosome
YCR016W_p	YCR016W	hom	FT	NUCLEUS	-0.000486300932936735	0.977533421021165	1898	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	nucleolus|nucleus
YKL014C	URB1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.000488534866690177	0.977430243145329	1899	Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus
YLR344W	RPL26A	hom	FT	TRANSLATION|RIBOSOME	-0.000489335356371732	0.977393271314879	1900	Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YHR182W	YHR182W	hom	FT	SIGNALING	-0.000490203574730409	0.9773531713876	1901	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cytoplasm
YLR368W	MDM30	hom	FT	MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION|MITOCHONDRION|UBIQUITIN LIGASE COMPLEX	-0.000491143180853395	0.977309774377088	1902	F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|chronological cell aging|proteolysis involved in cellular protein catabolic process|mitochondrion organization|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of mRNA export from nucleus|mitochondrial fusion	ubiquitin-protein ligase activity	mitochondrion|SCF ubiquitin ligase complex
YDL210W	UGA4	hom			-0.000492067215703453	0.977267096612859	1903	Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane	gamma-aminobutyric acid transport|putrescine transport|transmembrane transport	putrescine transmembrane transporter activity|gamma-aminobutyric acid:hydrogen symporter activity	fungal-type vacuole membrane|integral to membrane
YGR197C	SNG1	hom	FT	PLASMA MEMBRANE	-0.000493300046511241	0.977210156802703	1904	Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance	nucleobase-containing compound transport	molecular_function	integral to membrane|plasma membrane
YJL172W	CPS1	hom	FT	PROTEOLYSIS	-0.000494802007244365	0.977154420438994	1905	Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions	nitrogen compound metabolic process|proteolysis involved in cellular protein catabolic process	carboxypeptidase activity	fungal-type vacuole lumen
YLR206W	ENT2	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	-0.000497349965865498	0.977023107104863	1906	Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus	actin filament organization|endocytosis|actin cortical patch assembly	clathrin binding	mating projection tip|actin cortical patch
YPL005W	AEP3	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	-0.00050135138427542	0.976855567118344	1907	Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA	mRNA metabolic process|mitochondrial translational initiation	molecular_function	mitochondrion|mitochondrial inner membrane|cytoplasm|extrinsic to membrane
YPL119C-A_p	YPL119C-A	hom			-0.000503167346899965	0.976754427580889	1908	Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YDL182W	LYS20	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS|MITOCHONDRION	-0.000505521907549063	0.976645681414713	1909	Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication	lysine biosynthetic process via aminoadipic acid	homocitrate synthase activity	mitochondrion|nucleus
YJR110W	YMR1	hom	FT	LIPID METABOLISM	-0.000506629824252733	0.976594512063498	1910	Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family	phosphatidylinositol dephosphorylation	mRNA binding|phosphatidylinositol-3-phosphatase activity	cytoplasm
YIL146C	ATG32	hom	FT	CELL WALL ORG/BIOGENESIS|MITOCHONDRION	-0.000506702109772968	0.976591173545849	1911	Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane	fungal-type cell wall organization|mitochondrion degradation	molecular_function	integral to mitochondrial outer membrane
YDR499W	LCD1	het	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	-0.000506863963732083	0.976583698297835	1912	Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress	establishment of protein localization|telomere maintenance via telomerase|DNA damage checkpoint	damaged DNA binding	nuclear chromosome
YHR122W	CIA2	het	FT	CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS	-0.000509746863072078	0.976450551528714	1913	Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B	establishment of mitotic sister chromatid cohesion	molecular_function	nucleus|cytoplasm
YIL045W	PIG2	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	-0.000510763852117931	0.976403582023673	1914	Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase	regulation of glycogen biosynthetic process	protein phosphatase type 1 regulator activity	cytoplasm
YJL205C	NCE101	hom	FT	PROTEIN LOCALIZATION	-0.000511763210679333	0.976364475966786	1915	Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences	protein secretion	molecular_function	cellular_component
YGL142C	GPI10	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000512113719109395	0.976341238720932	1916	Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog	GPI anchor biosynthetic process	dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity	integral to membrane
YDR299W	BFR2	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.000515050548351066	0.976205602423926	1917	Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock	rRNA processing	molecular_function	nucleolus|90S preribosome
YPR117W_p	YPR117W	hom			-0.000518227561656106	0.976069581997171	1918	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR233C	RTN1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS	-0.00051830264991576	0.976055406201952	1919	Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication	endoplasmic reticulum tubular network organization|endoplasmic reticulum organization|endoplasmic reticulum tubular network maintenance|nuclear pore complex assembly	molecular_function	integral to endoplasmic reticulum membrane|mitochondrion|Golgi apparatus|endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YDR036C	EHD3	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	-0.000518679829036323	0.976037986481345	1920	3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis	fatty acid beta-oxidation|biological_process	3-hydroxyisobutyryl-CoA hydrolase activity	mitochondrion
YCL033C	MXR2	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS|MITOCHONDRION	-0.000519719312962406	0.976015043242462	1921	Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan	cellular response to oxidative stress	peptide-methionine (R)-S-oxide reductase activity	mitochondrion
YAR050W	FLO1	hom	FT	PLASMA MEMBRANE	-0.000519848283573575	0.97598402240139	1922	Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p	cellular response to stress|flocculation via cell wall protein-carbohydrate interaction|flocculation	mannose binding	fungal-type cell wall
YLR353W	BUD8	hom	FT	CELL CYCLE|CELL DIVISION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	-0.000521980501093529	0.975885548030362	1923	Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole	pseudohyphal growth|cellular bud site selection	molecular_function	incipient cellular bud site|plasma membrane|cellular bud tip
YGL016W	KAP122	hom	FT	PROTEIN LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	-0.000523693224896898	0.975806447830437	1924	Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance	protein import into nucleus|regulation of cell size	protein transporter activity	integral to membrane|nuclear pore|cytoplasm
YLR270W	DCS1	hom	FT	NUCLEUS|MITOCHONDRION	-0.000524215166633199	0.975782342592515	1925	Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of nuclease activity|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|enzyme activator activity|m7G(5')pppN diphosphatase activity	mitochondrion|nucleus|cytoplasmic mRNA processing body|cytoplasm
YPR058W	YMC1	hom	FT	MITOCHONDRION	-0.000524271005709286	0.975805047495851	1926	Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication	mitochondrial transport	organic acid transmembrane transporter activity	mitochondrion|integral to membrane
YBL019W	APN2	hom	FT	RESPONSE TO DNA DAMAGE|NUCLEUS	-0.000526714670563211	0.975666906380796	1927	Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII	base-excision repair	DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity	nucleus
YDR296W	MHR1	hom	FT	MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS|NUCLEUS|MITOCHONDRION	-0.000527323539125645	0.975638786686001	1928	Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress	cellular response to oxidative stress|positive regulation of mitochondrial DNA replication|regulation of transcription, DNA-dependent|mitochondrial genome maintenance|DNA recombination	single-stranded DNA binding|recombinase activity|DNA binding	mitochondrion|nucleus
YNL328C	MDJ2	hom	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	-0.000527931179102644	0.97561072376178	1929	Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain	protein import into mitochondrial matrix	protein transporter activity|ATPase activator activity	mitochondrial inner membrane|presequence translocase-associated import motor
YGL248W	PDE1	hom	FT	SIGNALING|NUCLEOTIDE METABOLISM	-0.000529707267067956	0.975528698025055	1930	Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation	cAMP-mediated signaling	3',5'-cyclic-AMP phosphodiesterase activity	cellular_component
YNL042W-B_p	YNL042W-B	hom			-0.000533343396604449	0.975360770098558	1931	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJR068W	RFC2	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	-0.00053491384362648	0.975299294598017	1932	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon	mismatch repair|sister chromatid cohesion|cell cycle checkpoint|leading strand elongation	DNA clamp loader activity|purine nucleotide binding	Elg1 RFC-like complex|DNA replication factor C complex|Rad17 RFC-like complex|Ctf18 RFC-like complex
YER025W	GCD11	het	FT	TRANSLATION|NUCLEOTIDE METABOLISM|RIBOSOME	-0.000536028051623818	0.975236784965312	1933	Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met	positive regulation of translational fidelity	GTP binding|tRNA binding|translation initiation factor activity	multi-eIF complex|ribosome|eukaryotic translation initiation factor 2 complex
YMR129W	POM152	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|NUCLEAR PORE	-0.000536302266133905	0.975224120979777	1934	Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210	nucleocytoplasmic transport|nuclear pore organization|protein import into nucleus|spindle pole body duplication associated with nuclear envelope	protein anchor|structural constituent of nuclear pore	mitochondrion|integral to membrane|nuclear pore transmembrane ring|nuclear envelope lumen|nuclear pore
YBL084C	CDC27	het	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	-0.000539179376169529	0.975102388852911	1935	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YDR454C	GUK1	het	FT	NUCLEOTIDE METABOLISM|NUCLEUS	-0.000541167605409633	0.974999427178045	1936	Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins	GMP metabolic process	guanylate kinase activity	nucleus|cytoplasm
YBR241C_p	YBR241C	hom			-0.000542233017386494	0.974950223994215	1937	Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene	transport|transmembrane transport	substrate-specific transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|membrane
YIL121W	QDR2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	-0.00054289390776156	0.974919702599374	1938	Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper	drug transmembrane transport|potassium ion import	drug transmembrane transporter activity	integral to membrane|integral to plasma membrane
YDR523C	SPS1	hom	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION|NUCLEUS	-0.000543069639500601	0.97491532659813	1939	Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis	ascospore wall assembly|ascospore formation|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	nucleus|prospore membrane|cytoplasm
YOR320C	GNT1	hom	FT	CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	-0.00054537067280668	0.974805320380076	1940	N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus	protein N-linked glycosylation	acetylglucosaminyltransferase activity	Golgi medial cisterna
YHR196W	UTP9	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|CHROMOSOME	-0.000545630409163654	0.974793325238756	1941	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|rDNA heterochromatin|nucleolus|t-UTP complex|nucleus|90S preribosome
YGR019W	UGA1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	-0.000547589622542457	0.974706615825185	1942	Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress	nitrogen utilization|gamma-aminobutyric acid catabolic process	4-aminobutyrate transaminase activity	intracellular
YBR150C	TBS1	hom	FT	TRANSCRIPTION FROM RNA POL II|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	-0.000549322912897704	0.974645503339799	1943	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication	biological_process	sequence-specific DNA binding	mitochondrion|nucleus|cytoplasm
YNL119W	NCS2	hom	FT	RNA PROCESSING	-0.000549517467402903	0.974647890504498	1944	Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	tRNA wobble position uridine thiolation|pseudohyphal growth|protein urmylation|invasive growth in response to glucose limitation	molecular_function	cytosol|cytoplasm
YBR050C	REG2	hom	FT	TRANSCRIPTION FROM RNA POL II	-0.000550976080362895	0.974546452785003	1945	Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease	negative regulation of transcription from RNA polymerase II promoter	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex
YDR436W	PPZ2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	-0.000552383833750529	0.974481440673719	1946	Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular sodium ion homeostasis	protein serine/threonine phosphatase activity	cellular_component
YJL106W	IME2	hom	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION|NUCLEUS	-0.000554514816171709	0.97439448605145	1947	Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p	protein phosphorylation|regulation of meiosis	protein kinase activity	nucleus
YKL162C_p	YKL162C	hom	FT	MITOCHONDRION	-0.000556703987903404	0.974281930693468	1948	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion
YML073C	RPL6A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	-0.000556958564764125	0.974285518393165	1949	Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YLR352W_p	YLR352W	hom			-0.00056002418626306	0.974144029671052	1950	Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene	biological_process	molecular_function	SCF ubiquitin ligase complex
YGL004C	RPN14	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|NUCLEUS	-0.000560765476593346	0.974121409634672	1951	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p	proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|cytoplasm
YDR505C	PSP1	hom	FT	MITOCHONDRION	-0.000561571277420663	0.974088107046718	1952	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|cytoplasm
YLR306W	UBC12	hom			-0.000566457952734577	0.973854898775917	1953	Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes	protein neddylation	NEDD8 ligase activity	cellular_component
YDR422C	SIP1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION	-0.000567756849912644	0.973771503415631	1954	Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions	signal transduction|protein phosphorylation|regulation of protein complex assembly	AMP-activated protein kinase activity	AMP-activated protein kinase complex|fungal-type vacuole
YGL229C	SAP4	hom	FT	CELL CYCLE|MITOCHONDRION	-0.000568909525177012	0.973718272849347	1955	Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p	G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	mitochondrion|cytoplasm
YML046W	PRP39	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	-0.000572110239424962	0.973570464416969	1956	U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats	mRNA 5'-splice site recognition	pre-mRNA 5'-splice site binding	commitment complex|U1 snRNP|U2-type prespliceosome
YBL107C	MIC23	hom			-0.000572921296281467	0.973533010094984	1957	Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C)	biological_process	molecular_function	cytoplasm
YFR018C_p	YFR018C	hom	FT	PROTEOLYSIS	-0.000575494843494204	0.973414164971377	1958	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YEL071W	DLD3	hom	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS	-0.000575499510220956	0.973413949464804	1959	D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm	lactate metabolic process|filamentous growth	D-lactate dehydrogenase (cytochrome) activity	cytoplasm
YKL184W	SPE1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	-0.000577131778263246	0.973370380927401	1960	Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation	pantothenate biosynthetic process|putrescine biosynthetic process	ornithine decarboxylase activity	cytoplasm
YLR189C	ATG26	hom	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM	-0.000577312614458582	0.973330221572451	1961	UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy	sterol metabolic process|ascospore-type prospore membrane assembly	sterol 3-beta-glucosyltransferase activity	cytoplasm
YER024W	YAT2	hom	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	-0.000578805005072896	0.973261304232488	1962	Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane	carnitine metabolic process|alcohol metabolic process	carnitine O-acetyltransferase activity	cytosol|cytoplasm
YBR249C	ARO4	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	-0.00058172779775357	0.973126332709999	1963	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress	aromatic amino acid family biosynthetic process	3-deoxy-7-phosphoheptulonate synthase activity	nucleus|cytoplasm
YKL062W	MSN4	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	-0.000581826532302522	0.973121773264751	1964	Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cellular response to acidity|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|replicative cell aging|age-dependent response to oxidative stress involved in chronological cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YHR029C	YHI9	hom	FT	SIGNALING	-0.000583423821608937	0.973076145854542	1965	Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production	endoplasmic reticulum unfolded protein response	molecular_function	cellular_component
YLR398C	SKI2	hom	FT	TRANSLATION	-0.00058373196877687	0.973033782623433	1966	Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay	RNA helicase activity	Ski complex
YJL109C	UTP10	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION|CHROMOSOME	-0.000585323190552331	0.972976427164773	1967	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	mitochondrion|90S preribosome|small-subunit processome|preribosome, small subunit precursor|integral to membrane|t-UTP complex|rDNA heterochromatin|nucleolus
YKR050W	TRK2	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	-0.000590849214818331	0.972705120131894	1968	Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication	cellular potassium ion homeostasis	potassium ion transmembrane transporter activity	integral to membrane|plasma membrane
YNL209W	SSB2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS	-0.000592221876177518	0.97265804818508	1969	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication	cellular response to glucose starvation|cytoplasmic translation|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity|'de novo' cotranslational protein folding	unfolded protein binding|ATPase activity	plasma membrane|polysome|cytoplasm
YDL018C	ERP3	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000592465371118508	0.972630489386553	1970	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YDR437W	GPI19	het	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	-0.000594521835265298	0.972535526484641	1971	Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P	GPI anchor biosynthetic process	UDP-glycosyltransferase activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|nuclear envelope|integral to endoplasmic reticulum membrane|endoplasmic reticulum
YOR291W	YPK9	hom	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	-0.000598001073481921	0.972391337694126	1972	Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YBR084W	MIS1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	-0.000599568746272883	0.972302473106195	1973	Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase	nucleobase-containing compound metabolic process|folic acid biosynthetic process	formate-tetrahydrofolate ligase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methenyltetrahydrofolate cyclohydrolase activity	mitochondrion
YOR187W	TUF1	hom	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|MITOCHONDRION	-0.000600316088962552	0.972267962942109	1974	Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans	mitochondrial translational elongation|mitochondrial translation	GTPase activity|translation elongation factor activity	mitochondrion|mitochondrial matrix
YDR042C_p	YDR042C	hom			-0.000602770017664079	0.972171252800986	1975	Putative protein of unknown function; expression is increased in ssu72-ts69 mutant	biological_process	molecular_function	cellular_component
YGR132C	PHB1	hom	FT	MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	-0.000604769830797706	0.972091464364007	1976	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation	mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging|mitochondrion morphogenesis|inner mitochondrial membrane organization	molecular_function	mitochondrion|mitochondrial inner membrane
YOR023C	AHC1	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|HISTONE ACETYLTRANSFERASE	-0.000605517559121213	0.972027775255641	1977	Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex	histone acetylation	histone acetyltransferase activity	Ada2/Gcn5/Ada3 transcription activator complex
YDR085C	AFR1	hom	FT	SIGNALING	-0.000606518603292705	0.971981550444903	1978	Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication	regulation of G-protein coupled receptor protein signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation	receptor signaling protein activity	mating projection base
YGR191W	HIP1	het	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	-0.000614117047411624	0.971630683250614	1979	High-affinity histidine permease, also involved in the transport of manganese ions	manganese ion transport|histidine transport	high affinity L-histidine transmembrane transporter activity	integral to membrane|plasma membrane
YAL037C-A_p	YAL037C-A	hom			-0.000614951897663472	0.971592133380707	1980	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR150C	IMP1	hom	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|MITOCHONDRION	-0.000615122826694284	0.971584240605855	1981	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	protein processing involved in protein targeting to mitochondrion	endopeptidase activity	mitochondrion|mitochondrial inner membrane peptidase complex
YOR019W	YOR019W	hom	FT	CELL CYCLE	-0.000618013842099937	0.971450746245964	1982	Protein of unknown function that may interact with ribosomes, based on co-purification experiments	mitochondrion degradation	molecular_function	ribosome
YLL056C_p	YLL056C	hom			-0.000618853689640045	0.971420488393163	1983	Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin	biological_process	molecular_function	cellular_component
YMR039C	SUB1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	-0.000620335059564213	0.971343563224195	1984	Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress	termination of RNA polymerase II transcription|hyperosmotic response|RNA polymerase III transcriptional preinitiation complex assembly|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase III promoter	transcription coactivator activity	nucleus
YGR057C	LST7	hom	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM	-0.000621727874195902	0.971279249773551	1985	Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface	intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport	protein transporter activity	vesicle coat
YLR015W	BRE2	hom	FT	CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS|CHROMOSOME	-0.000622008734396598	0.971266281028995	1986	Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L	histone H3-K4 methylation|telomere maintenance|histone H3-K4 trimethylation|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YOR329C	SCD5	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|NUCLEUS|CYTOSKELETON	-0.000623037023770255	0.971218799741237	1987	Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency	protein secretion|endocytosis|actin filament organization|cortical actin cytoskeleton organization	protein phosphatase 1 binding	nucleus|actin cortical patch
YGR026W_p	YGR026W	hom	FT	PLASMA MEMBRANE	-0.000624997676992415	0.971128266811965	1988	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	integral to membrane
YDR402C	DIT2	hom	FT	CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS	-0.000625315948631524	0.971113570691946	1989	N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s	ascospore wall assembly	oxidoreductase activity	cellular_component
YJR003C_p	YJR003C	hom	FT	MITOCHONDRION	-0.000628946873596419	0.970950244571523	1990	Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	mitochondrion
YCR007C_p	YCR007C	hom			-0.000630310214617581	0.970978586174053	1991	Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene	biological_process	molecular_function	cellular_component
YJR009C	TDH2	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	-0.000631625174074437	0.97082224568253	1992	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; TDH2 has a paralog, TDH3, that arose from the whole genome duplication	gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YDR089W	YDR089W	hom	FT	MEMBRANE ORGANIZATION	-0.000632835943627881	0.970779412621731	1993	Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress	cellular membrane organization	molecular_function	integral to membrane|membrane
YDL133C-A	RPL41B	hom	FT	TRANSLATION|RIBOSOME	-0.000635331844227798	0.97065109404222	1994	Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YNL254C	RTC4	hom	FT	NUCLEUS	-0.000635581624344558	0.970639560753538	1995	Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YOR249C	APC5	het	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	-0.000639598275744862	0.970454097675929	1996	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress	chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YOR025W	HST3	hom	FT	KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|GENE SILENCING|NUCLEUS	-0.000639736174689452	0.970447730419614	1997	Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism	short-chain fatty acid metabolic process|histone deacetylation|chromatin silencing at telomere	histone deacetylase activity|DNA binding	nucleus
YDL130W	RPP1B	hom	FT	TRANSLATION|RIBOSOME	-0.000639806984664566	0.970470900660451	1998	Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component	cytoplasmic translation|translational elongation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR107W_d	YGR107W	hom			-0.00064389259206125	0.970255815588595	1999	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR111C	YMR111C	hom	FT	NUCLEUS	-0.000650714648491446	0.96994082357574	2000	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress	biological_process	molecular_function	nucleus
YJR041C	URB2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.000652392091777251	0.969885836640395	2001	Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis	rRNA metabolic process|ribosome biogenesis	molecular_function	nucleolus
YBR084C-A	RPL19A	hom	FT	TRANSLATION|RIBOSOME	-0.000654379654665719	0.969861834314038	2002	Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR163W	CWC15	hom	FT	RNA PROCESSING|NUCLEUS	-0.00065519700522868	0.969733864105437	2003	Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YLR022C	SDO1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	-0.000655710236455837	0.969710167312067	2004	Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes	mature ribosome assembly	molecular_function	nucleus|preribosome, large subunit precursor|polysome|cytoplasm
YBR189W	RPS9B	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEUS|RIBOSOME	-0.000657752604887017	0.96961586781487	2005	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication	positive regulation of translational fidelity|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YFL034C-B	MOB2	het	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS|SITE OF POLARIZED GROWTH	-0.000662559825053497	0.969393912260753	2006	Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p	positive regulation of protein phosphorylation|establishment or maintenance of cell polarity|Unknown|budding cell apical bud growth	protein kinase activator activity	nucleus|cellular bud|cellular bud neck|mating projection tip|cellular bud tip
YFL045C	SEC53	het	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM	-0.00066490742293397	0.969335912152049	2007	Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen	protein targeting to ER	phosphomannomutase activity	cytosol
YGR012W	YGR012W	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	-0.000665111443795078	0.969276101694694	2008	Putative cysteine synthase, localized to the mitochondrial outer membrane	cysteine biosynthetic process	cysteine synthase activity	mitochondrial outer membrane|mitochondrion
YAR008W	SEN34	het	FT	RNA PROCESSING|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	-0.000665786855203029	0.96924491744564	2009	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease	tRNA-type intron splice site recognition and cleavage	tRNA-intron endonuclease activity	mitochondrial outer membrane|mitochondrion|tRNA-intron endonuclease complex
YGR149W_p	YGR149W	hom			-0.000666153228874309	0.969228001719317	2010	Putative protein of unknown function; predicted to be an integal membrane protein	biological_process	molecular_function	integral to membrane
YKL040C	NFU1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM|MITOCHONDRION	-0.000666694328524608	0.969203018798761	2011	Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria	cellular iron ion homeostasis|iron-sulfur cluster assembly|intracellular sequestering of iron ion	molecular_function	mitochondrion|mitochondrial matrix
YML047C	PRM6	hom			-0.000668259442005927	0.969130756667978	2012	Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family	biological_process	molecular_function	integral to membrane
YPR040W	TIP41	hom	FT	SIGNALING|NUCLEUS	-0.000669996420717708	0.969050559723739	2013	Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress	signal transduction	molecular_function	nucleus|cytoplasm
YGL223C	COG1	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	-0.000672254489010664	0.968978715225808	2014	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YGR015C_p	YGR015C	hom	FT	MITOCHONDRION	-0.000673500095226072	0.96888879473935	2015	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion
YML119W_p	YML119W	hom			-0.000673985157236343	0.968866399481008	2016	Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate	biological_process	molecular_function	cellular_component
YOR057W	SGT1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|SIGNALING|UBIQUITIN LIGASE COMPLEX	-0.000674878038481259	0.968825175318749	2017	Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress	regulation of cell cycle|kinetochore assembly|cAMP-mediated signaling|protein complex assembly|protein ubiquitination	protein binding, bridging|chaperone binding	ubiquitin ligase complex
YEL001C	IRC22	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000675435111593032	0.968799455398184	2018	Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	endoplasmic reticulum
YNL227C	JJJ1	hom	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS|MITOCHONDRION|RIBOSOME	-0.000676341433828107	0.968757610805838	2019	Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis	ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|endocytosis|regulation of cell size|rRNA processing	ATPase activator activity	cytosol|mitochondrion|cytosolic large ribosomal subunit|nucleolus|cytoplasm
YJL189W	RPL39	hom	FT	TRANSLATION|RIBOSOME	-0.000676367231571715	0.968756419733962	2020	Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YIL099W	SGA1	hom	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	-0.000676799307718393	0.968736470955217	2021	Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation	ascospore formation|glycogen catabolic process	glucan 1,4-alpha-glucosidase activity	fungal-type vacuole
YFL008W	SMC1	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	-0.000677173113662918	0.968779871083123	2022	Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure	double-strand break repair|mitotic sister chromatid cohesion|mitotic sister chromatid segregation	double-stranded DNA binding|ATPase activity|AT DNA binding|DNA secondary structure binding	nuclear mitotic cohesin complex
YJR083C	ACF4	hom			-0.00067719407532849	0.968718244713421	2023	Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate	biological_process	molecular_function	cellular_component
YHR166C	CDC23	het	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|CHROMOSOME|UBIQUITIN LIGASE COMPLEX	-0.000677756863581955	0.968692261062848	2024	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity|cyclin binding	anaphase-promoting complex
YEL037C	RAD23	hom	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS|NUCLEUS|MITOCHONDRION	-0.000678869053295095	0.968645585437593	2025	Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover	proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair, DNA damage recognition|ER-associated protein catabolic process|protein deglycosylation	damaged DNA binding|ubiquitin binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding, bridging	proteasome complex|mitochondrion|nucleotide-excision repair factor 2 complex
YDR390C	UBA2	het	FT	NUCLEUS	-0.000679302064044071	0.968620920105675	2026	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability	protein sumoylation	SUMO activating enzyme activity	SUMO activating enzyme complex|nucleus
YKL090W	CUE2	hom			-0.0006802176053336	0.968578650244516	2027	Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination	biological_process	ubiquitin binding	cellular_component
YGL156W	AMS1	hom	FT	CARBOHYDRATE METABOLISM	-0.000680491592742763	0.968566000466536	2028	Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway	oligosaccharide catabolic process|cellular carbohydrate metabolic process	alpha-mannosidase activity	fungal-type vacuole membrane
YGR161W-C_p	YGR161W-C	hom			-0.000681269229000614	0.968530097669981	2029	Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	cellular_component
YLR011W	LOT6	hom	FT	PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS|NUCLEUS	-0.000681584907346583	0.968515523090707	2030	FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions	cellular response to oxidative stress|cytoplasmic sequestering of transcription factor	NAD(P)H dehydrogenase (quinone) activity|transcription factor binding	cytosol|nucleus|cytoplasm
YOL097W-A_p	YOL097W-A	hom			-0.000682303303303371	0.968482355448435	2031	Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YGL158W	RCK1	hom	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	-0.00068309860897337	0.968445637023105	2032	Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication	protein phosphorylation|regulation of meiosis	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YPL011C	TAF3	het	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS|RNA POL II, HOLOENZYME	-0.000685277789202249	0.968345026909455	2033	TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation	RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter	chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	transcription factor TFIID complex
YKL022C	CDC16	het	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|NUCLEUS|UBIQUITIN LIGASE COMPLEX	-0.000685921181840404	0.968315322346291	2034	Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of DNA-dependent DNA replication initiation|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YDR119W_p	VBA4	hom			-0.000686341322333782	0.968333743851651	2035	Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YLR154C	RNH203	hom	FT	NUCLEUS	-0.000689956547916559	0.96814801914494	2036	Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome	RNA catabolic process|DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus|cytoplasm
YDR088C	SLU7	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	-0.000690324252480568	0.968126298631203	2037	RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain	generation of catalytic spliceosome for second transesterification step	second spliceosomal transesterification activity	spliceosomal complex
YKL108W	SLD2	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS	-0.000691531395251215	0.968056308288948	2038	Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; unphosphorylated or CDK-phosphorylated Sld2p binds to the MCM2-7 complex;required for the S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress	DNA replication preinitiation complex assembly|DNA strand renaturation|DNA replication initiation|double-strand break repair via break-induced replication|mitotic cell cycle DNA replication checkpoint	DNA replication origin binding|single-stranded DNA binding	DNA replication preinitiation complex
YDR504C	SPG3	hom			-0.000692264571183094	0.968022459045422	2039	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	biological_process	molecular_function	cellular_component
YGR096W	TPC1	hom	FT	MITOCHONDRION	-0.000692787567094039	0.968003082604513	2040	Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family	thiamine pyrophosphate transport	thiamine transmembrane transporter activity	integral to membrane|integral to mitochondrial inner membrane
YDR516C	EMI2	hom	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	-0.000694572489306099	0.967949392694834	2041	Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YDR111C_p	ALT2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	-0.000694899397582179	0.967900814938296	2042	Catalytically inactive paralog of ALT1, an alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p	biological_process	transaminase activity	nucleus|cytoplasm
YKL189W	HYM1	het	FT	CELL DIVISION|SITE OF POLARIZED GROWTH	-0.00069493423668938	0.967899206498769	2043	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response	cytokinesis, completion of separation|regulation of cell shape|regulation of transcription, DNA-dependent|budding cell apical bud growth	molecular_function	incipient cellular bud site|intracellular|cellular bud|mating projection tip
YDR339C	FCF1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.000696300754284451	0.967836117702825	2044	Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus
YOR380W	RDR1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	-0.000697961208938715	0.96778348970166	2045	Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins	response to xenobiotic stimulus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YOR269W	PAC1	hom	FT	CELL CYCLE|CELL DIVISION|NUCLEUS|CYTOSKELETON	-0.000698078341969133	0.967754051101156	2046	Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly	nuclear migration along microtubule	microtubule plus-end binding	cytoplasmic microtubule|nucleus|cytoplasm
YJL122W	ALB1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	-0.000698343740192593	0.967741798384481	2047	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p	ribosomal large subunit biogenesis	molecular_function	ribosome|nucleus|cytoplasm
YNL256W	FOL1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM|MITOCHONDRION	-0.000699942190896303	0.967668002408819	2048	Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities	tetrahydrofolate biosynthetic process	dihydroneopterin aldolase activity|2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity|dihydropteroate synthase activity	mitochondrial envelope|mitochondrion|cytoplasm
YLL057C	JLP1	hom	FT	OXIDATION-REDUCTION PROCESS	-0.000701060509964649	0.967616372925596	2049	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation	sulfur compound catabolic process	sulfonate dioxygenase activity	cellular_component
YBR261C	TAE1	hom	FT	TRANSLATION	-0.000703160797008964	0.967519409252604	2050	AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm	cytoplasmic translation|N-terminal peptidyl-proline dimethylation	N-terminal protein N-methyltransferase activity	cytosol|cytoplasm
YML029W	USA1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|UBIQUITIN LIGASE COMPLEX	-0.000705322897791052	0.967429303727735	2051	Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p	ER-associated protein catabolic process|mRNA splicing, via spliceosome|positive regulation of protein oligomerization	protein complex scaffold	Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YGL018C	JAC1	het	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	-0.000705580171505412	0.967407714906616	2052	Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix	iron-sulfur cluster assembly|aerobic respiration	chaperone binding	mitochondrion
YLR046C_p	YLR046C	hom			-0.000707032729230379	0.967340655531225	2053	Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	biological_process	molecular_function	integral to membrane
YDL075W	RPL31A	hom	FT	TRANSLATION|RIBOSOME	-0.000707425151264943	0.967322538854296	2054	Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication	cytoplasmic translation|regulation of translational fidelity	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR234W	YHB1	hom	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION	-0.000707595639395691	0.96733415623134	2055	Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	response to stress	nitric oxide reductase activity	cytosol|mitochondrion|mitochondrial matrix|cytoplasm
YPL151C	PRP46	het	FT	CELL CYCLE|RNA PROCESSING|NUCLEUS	-0.000709892766472821	0.967213505293912	2056	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs	mRNA splicing, via spliceosome	molecular_function	Prp19 complex|spliceosomal complex
YFR027W	ECO1	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	-0.000712345491215153	0.967095386353387	2057	Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress	double-strand break repair|regulation of DNA replication|mitotic chromosome condensation|internal peptidyl-lysine acetylation|establishment of mitotic sister chromatid cohesion|DNA repair|chromosome organization|DNA replication|regulation of mitosis|telomere organization|tRNA gene clustering	acetyltransferase activity|chromatin binding	nuclear chromatin|nuclear replication fork
YKL102C_d	YKL102C	hom			-0.000715924698952435	0.966930150261567	2058	Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site	Unknown	Unknown	Unknown
YBR055C	PRP6	het	FT	RNA PROCESSING|NUCLEUS	-0.000716831701254751	0.966932714606623	2059	Splicing factor, component of the U4/U6-U5 snRNP complex	mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YNL134C	YNL134C	hom	FT	OXIDATION-REDUCTION PROCESS|NUCLEUS	-0.000716874273134276	0.966886312885634	2060	Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress	biological_process	alcohol dehydrogenase (NADP+) activity	nucleus|cytoplasm
YGR201C_p	YGR201C	hom			-0.000717921304930077	0.96683797646578	2061	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR258C	HSP78	hom	FT	PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	-0.000718611571397254	0.96680611025105	2062	Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates	positive regulation of mitochondrial translation in response to stress|protein refolding|protein stabilization|protein import into mitochondrial matrix|mitochondrial genome maintenance|protein unfolding|cellular response to heat	misfolded protein binding|ATPase activity	mitochondrion|mitochondrial matrix
YOR378W_p	YOR378W	hom	FT	PLASMA MEMBRANE	-0.000719109031994666	0.96678314496982	2063	Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene	biological_process	molecular_function	integral to membrane
YAL067C	SEO1	hom			-0.000719618780010087	0.966759612468189	2064	Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide	transport	transporter activity	integral to membrane|membrane
YDL149W	ATG9	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|ENDOMEMBRANE SYSTEM|MITOCHONDRION	-0.000721144403017363	0.966689182301426	2065	Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS	piecemeal microautophagy of nucleus|mitochondrion degradation|protein homooligomerization|CVT pathway|autophagic vacuole assembly	molecular_function	mitochondrion|integral to membrane|pre-autophagosomal structure
YPR116W	RRG8	hom	FT	MITOCHONDRION ORGANIZATION|MITOCHONDRION	-0.000722047581453849	0.966662400344985	2066	Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport	mitochondrial genome maintenance	molecular_function	mitochondrion
YGR152C	RSR1	hom	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	-0.000725394093399952	0.966492997327125	2067	GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases	bipolar cellular bud site selection|small GTPase mediated signal transduction|axial cellular bud site selection|cellular bud site selection	GTPase activity|signal transducer activity	plasma membrane|cellular bud neck
YDR193W_d	YDR193W	hom			-0.000725880516834264	0.966515538277185	2068	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR196C	CAB5	het	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION	-0.000726497394633391	0.966442064271296	2069	Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies	coenzyme A biosynthetic process	dephospho-CoA kinase activity	nuclear envelope|mitochondrion|endoplasmic reticulum
YOL019W-A_p	YOL019W-A	hom			-0.000728059060647675	0.966395036744314	2070	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YJR014W	TMA22	hom	FT	TRANSLATION|RIBOSOME	-0.000728420547405719	0.966378361501503	2071	Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress	biological_process	RNA binding	ribosome|cytoplasm
YPL004C	LSP1	hom	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|MITOCHONDRION	-0.000729026864377886	0.966325293756074	2072	Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family	negative regulation of protein kinase activity|endocytosis|response to heat	lipid binding	mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YOR062C_p	YOR062C	hom	FT	NUCLEUS	-0.000729367110746323	0.966309586667796	2073	Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YGL010W_p	YGL010W	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000729883735191941	0.966285737310312	2074	Putative protein of unknown function; YGL010W is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YJL049W_p	YJL049W	hom	FT	PROTEIN LOCALIZATION	-0.000732711739821994	0.966155186350674	2075	Putative protein of unknown function; YJL049W is a non-essential gene	biological_process	molecular_function	cellular_component
YGL245W	GUS1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION	-0.000732786241813145	0.966151747080557	2076	Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress	glutamyl-tRNA aminoacylation	glutamate-tRNA ligase activity	methionyl glutamyl tRNA synthetase complex|mitochondrion|cytoplasm
YGL164C	YRB30	hom	FT	PROTEIN LOCALIZATION|NUCLEUS	-0.000734329795472363	0.966080491435766	2077	RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes	biological_process	GTPase regulator activity	nucleus|cytoplasm
YLR108C	YLR108C	hom	FT	NUCLEUS	-0.000735386999048567	0.96603168750791	2078	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus
YGL073W	HSF1	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION|NUCLEUS|MITOCHONDRION	-0.000735468924006362	0.966027905592857	2079	Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated	spindle pole body duplication|negative regulation of TOR signaling cascade|response to heat|regulation of transcription from RNA polymerase II promoter|response to stress	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	mitochondrion|nucleus
YOR299W	BUD7	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|GOLGI APPARATUS	-0.000736857150694339	0.965984113421923	2080	Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication	Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process|cellular bud site selection	molecular_function	trans-Golgi network transport vesicle|clathrin-coated vesicle|exomer complex
YLR054C	OSW2	hom	FT	CELL WALL ORG/BIOGENESIS	-0.000740816724684609	0.965786135092243	2081	Protein of unknown function proposed to be involved in the assembly of the spore wall	ascospore wall assembly	molecular_function	integral to membrane|prospore membrane|cytoplasm
YGR021W_p	YGR021W	hom	FT	MITOCHONDRION	-0.000743741738004778	0.965646010292201	2082	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPL121C	MEI5	hom	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME	-0.000746376310970757	0.965524392981545	2083	Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p	meiotic DNA recombinase assembly|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YKL072W	STB6	hom			-0.000747273472897958	0.96548297832325	2084	Protein that binds Sin3p in a two-hybrid assay	biological_process	molecular_function	cellular_component
YHL016C	DUR3	hom	FT	PLASMA MEMBRANE	-0.000747420728114694	0.965476180758257	2085	Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway	urea transport|spermidine transport|putrescine transport|urea catabolic process	urea transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity	integral to membrane|plasma membrane
YOL158C	ENB1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	-0.000747431110196998	0.965475701502807	2086	Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment	ferric-enterobactin transport	ferric-enterobactin transmembrane transporter activity	integral to membrane|cellular bud membrane|plasma membrane
YMR175W	SIP18	hom			-0.000747473894839185	0.965473726487486	2087	Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress	cellular response to water deprivation	phospholipid binding	cytoplasm
YER050C	RSM18	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	-0.00074754599302936	0.965470398307035	2088	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YFL063W_d	YFL063W	hom			-0.000748420693680538	0.965450631126239	2089	Dubious open reading frame, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR363C	NMD4	hom			-0.000749453004520435	0.96538236748965	2090	Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	molecular_function	cytoplasm
YJL162C	JJJ2	hom	FT	NUCLEUS	-0.00074995559025492	0.965359167367681	2091	Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein	biological_process	molecular_function	nucleus|cytoplasm
YLR023C	IZH3	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000752999501037514	0.965239392804579	2092	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity	cellular zinc ion homeostasis	metal ion binding	integral to membrane|endoplasmic reticulum|membrane
YFR012W	DCV1	hom			-0.000753210702149846	0.965208907161952	2093	Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YOR046C	DBP5	het	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|NUCLEUS|SITE OF POLARIZED GROWTH|NUCLEAR PORE	-0.000753993099396639	0.965172790869636	2094	Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p	translational termination|mRNA export from nucleus	RNA helicase activity|inositol hexakisphosphate binding|RNA-dependent ATPase activity	nuclear pore cytoplasmic filaments|nucleus|polysome|nuclear pore|cellular bud tip|cytoplasm
YAL011W	SWC3	hom	FF|FT	CHROMATIN ORGANIZATION|NUCLEUS|MITOCHONDRION|CHROMOSOME	-0.000754492411300333	0.965149742136349	2095	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae	endoplasmic reticulum organization|chromatin remodeling|histone exchange	molecular_function	mitochondrion|Swr1 complex|nucleus
YJR127C	RSF2	hom	FT	NUCLEUS	-0.000755314523311308	0.965111792692994	2096	Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YGL096W	TOS8	hom	FT	NUCLEUS|CHROMOSOME	-0.000755388733039249	0.965108367107873	2097	Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication	biological_process	chromatin binding|sequence-specific DNA binding	nuclear chromatin
YDR100W	TVP15	hom	FT	VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	-0.000755571093322698	0.965099949202457	2098	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p	vesicle-mediated transport	molecular_function	COPI-coated vesicle|integral to membrane|integral to Golgi membrane
YOR314W_d	YOR314W	hom			-0.000758556584040759	0.964962136971275	2099	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL166W	CUP2	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	-0.000759827042634068	0.9649191839182	2100	Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter|response to copper ion	RNA polymerase II core promoter proximal region sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|copper ion binding	nucleus
YMR036C	MIH1	hom	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|NUCLEUS	-0.000760307073929343	0.96488133368355	2101	Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25	G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	protein tyrosine phosphatase activity	nucleus|cytoplasm
YGL214W_d	YGL214W	hom			-0.000760583059525509	0.964868594114969	2102	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C	Unknown	Unknown	Unknown
YER055C	HIS1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	-0.000763113866192901	0.964751771823948	2103	ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control	histidine biosynthetic process	ATP phosphoribosyltransferase activity	cellular_component
YDR246W	TRS23	het	FT	VESICLE-MEDIATED TRANSPORT|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	-0.000763747198362333	0.96472253726534	2104	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4	chromosome organization|ER to Golgi vesicle-mediated transport	Rab guanyl-nucleotide exchange factor activity	TRAPP complex
YMR182W-A_p	YMR182W-A	hom			-0.00076490931051225	0.96466889439151	2105	Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDL179W	PCL9	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH	-0.000766197768896839	0.964609419586591	2106	Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p	regulation of establishment or maintenance of cell polarity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|cellular bud neck
YDL201W	TRM8	hom	FT	RNA PROCESSING|NUCLEUS	-0.000766221412173837	0.964608328222728	2107	Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p	tRNA methylation	tRNA (guanine-N7-)-methyltransferase activity	tRNA methyltransferase complex|nucleus
YIR004W	DJP1	hom	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	-0.00076738633134867	0.964554556118776	2108	Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ	protein import into peroxisome matrix	chaperone binding	cytosol
YNL245C	CWC25	het	FT	RNA PROCESSING|NUCLEUS	-0.000769822625177586	0.964442098498749	2109	Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YBR083W	TEC1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	-0.000773131142197827	0.964289380798337	2110	Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member	pseudohyphal growth|chronological cell aging|positive regulation of transposition, RNA-mediated|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YKL004W	AUR1	het	FT	LIPID METABOLISM|ENDOMEMBRANE SYSTEM|GOLGI APPARATUS	-0.000774890564606533	0.964208168225041	2111	Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance	inositolphosphoceramide metabolic process|sphingolipid biosynthetic process	inositol phosphoceramide synthase activity	integral to membrane|Golgi apparatus|inositol phosphoceramide synthase complex
YDR277C	MTH1	hom	FT	SIGNALING	-0.000779297188489307	0.964036959496909	2112	Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation	glucose transport|signal transduction	molecular_function	cellular_component
YMR023C	MSS1	hom	FT	RNA PROCESSING|SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|MITOCHONDRION	-0.000780045532082521	0.963970223995702	2113	Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3	mitochondrial tRNA wobble uridine modification|Unknown	GTP binding	mitochondrion|mitochondrial inner membrane
YOL164W-A_p	YOL164W-A	hom			-0.000780871085758285	0.963937492572278	2114	Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YPR200C	ARR2	hom			-0.000781317668953084	0.963916882340227	2115	Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p	response to arsenic-containing substance	arsenate reductase activity	cellular_component
YER069W	ARG5,6	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION	-0.00078150490049513	0.963902862698881	2116	Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine	ornithine biosynthetic process|arginine biosynthetic process|regulation of transcription, DNA-dependent	N-acetyl-gamma-glutamyl-phosphate reductase activity|acetylglutamate kinase activity	mitochondrion|mitochondrial matrix
YER039C	HVG1	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS	-0.000782477559419799	0.96385796700476	2117	Protein of unknown function, has homology to Vrg4p	biological_process	molecular_function	integral to membrane
YDR425W	SNX41	hom	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	-0.000785439879409386	0.963737453565818	2118	Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p	retrograde transport, endosome to Golgi	phosphatidylinositol binding|phosphatidylinositol-3-phosphate binding	endosome
YOL061W	PRS5	hom	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM	-0.000787669255828986	0.963618332205369	2119	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YJR017C	ESS1	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING|NUCLEUS	-0.0007886325678092	0.963573868665401	2120	Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3	termination of RNA polymerase II transcription|positive regulation of protein dephosphorylation|negative regulation of histone deacetylation|negative regulation of transcription from RNA polymerase II promoter|protein peptidyl-prolyl isomerization|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle	peptidyl-prolyl cis-trans isomerase activity|RNA polymerase II core binding	nucleus
YLR297W	YLR297W	hom			-0.000790774730902785	0.963474993363183	2121	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication	biological_process	molecular_function	fungal-type vacuole
YPR023C	EAF3	hom	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|NUCLEUS|CHROMOSOME|HISTONE ACETYLTRANSFERASE	-0.000791448928643021	0.963443874697731	2122	Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition	DNA repair|histone acetylation|regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|histone deacetylation	histone acetyltransferase activity	Rpd3S complex|histone acetyltransferase complex|Rpd3L complex|NuA4 histone acetyltransferase complex
YNL177C	MRPL22	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	-0.000791466138010842	0.963443080372807	2123	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGL145W	TIP20	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000793072413385445	0.963368940414342	2124	Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p	retrograde vesicle-mediated transport, Golgi to ER	molecular_function	Dsl1p complex|endoplasmic reticulum
YNL128W	TEP1	hom	FT	CELL WALL ORG/BIOGENESIS	-0.000793197563781723	0.963368622974924	2125	PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1	ascospore wall assembly|phosphatidylinositol dephosphorylation	molecular_function	cytoplasm
YDR320C	SWA2	hom	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000793662172236184	0.963341719322733	2126	Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles	positive regulation of ATPase activity|endoplasmic reticulum inheritance|clathrin coat disassembly	ubiquitin binding|clathrin binding	endoplasmic reticulum membrane
YDL240W	LRG1	hom	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|MITOCHONDRION|SITE OF POLARIZED GROWTH	-0.000794362498068262	0.963309394922866	2127	Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis	fungal-type cell wall biogenesis|small GTPase mediated signal transduction	Rho GTPase activator activity	mitochondrion|cellular bud neck|cytoplasm
YPL123C	RNY1	hom			-0.000795341994973047	0.963269658911905	2128	Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity	cell morphogenesis|RNA catabolic process|apoptotic process	endoribonuclease activity	cytosol|extracellular region|vacuole
YPL020C	ULP1	het	FT	CELL CYCLE|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|NUCLEAR PORE	-0.00079579591359612	0.963243234054724	2129	Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions	G2/M transition of mitotic cell cycle|protein desumoylation	cysteine-type peptidase activity|SUMO-specific protease activity	nuclear envelope|nucleolus|nuclear pore
YDR025W	RPS11A	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RIBOSOME	-0.000796764399292526	0.963225958579174	2130	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YDR201W	SPC19	het	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	-0.000796788567343046	0.963197417178937	2131	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body	microtubule nucleation|mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization	microtubule binding|structural constituent of cytoskeleton	spindle microtubule|condensed nuclear chromosome kinetochore|DASH complex|spindle pole body|spindle
YDR387C_p	YDR387C	hom			-0.000797043724524388	0.963185640176689	2132	Putative transporter, member of the sugar porter family; YDR387C is not an essential gene	transport|transmembrane transport	substrate-specific transmembrane transporter activity	integral to membrane|membrane
YBR065C	ECM2	hom	FT	RNA PROCESSING|NUCLEUS	-0.0007974477194194	0.963166993456372	2133	Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p	mRNA splicing, via spliceosome	molecular_function	nucleus
YEL038W	UTR4	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	-0.000799181999092728	0.963086946564821	2134	Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus	L-methionine salvage from methylthioadenosine	acireductone synthase activity	nucleus|cytoplasm
YJL045W	YJL045W	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|MITOCHONDRION	-0.00079925016405832	0.963083800370739	2135	Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner	cellular respiration	succinate dehydrogenase (ubiquinone) activity	mitochondrion
YDR500C	RPL37B	hom	FT	TRANSLATION|RIBOSOME	-0.000800123669760988	0.963048989862446	2136	Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YIL088C	AVT7	hom	FT	PLASMA MEMBRANE	-0.000801657271881619	0.962989253162948	2137	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane|fungal-type vacuole
YCR027C	RHB1	hom	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|PLASMA MEMBRANE	-0.000801973378453925	0.962963628591992	2138	Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins	lysine transport|retrograde transport, endosome to Golgi|arginine transport	GTPase activity	extrinsic to plasma membrane
YHR014W	SPO13	hom	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME	-0.000803382596240684	0.962893066607706	2139	Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II	protein localization to chromosome, centromeric region|meiotic sister chromatid cohesion|positive regulation of sister chromatid cohesion	molecular_function	nucleus|condensed nuclear chromosome, centromeric region
YIR007W_p	YIR007W	hom	FT	CARBOHYDRATE METABOLISM	-0.000803401823038754	0.962892179193486	2140	Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene	biological_process	molecular_function	cytoplasm
YBR130C	SHE3	hom	FT	RNA LOCALIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|CYTOSKELETON	-0.000804407402765887	0.962845766654377	2141	Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance	mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization	mRNA binding	actin cap|cytoplasm|cellular bud tip
YDR282C_p	YDR282C	hom			-0.00080521578485229	0.962808455864948	2142	Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation	biological_process	molecular_function	cellular_component
YOR372C	NDD1	het	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|NUCLEUS	-0.000805803233366553	0.962825730431028	2143	Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes	positive regulation of transcription involved in G2/M-phase of mitotic cell cycle	transcription coactivator activity	nucleus
YDR300C	PRO1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	-0.000806861031975021	0.962732519910092	2144	Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication	proline biosynthetic process	glutamate 5-kinase activity	cytoplasm
YPL092W	SSU1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|PLASMA MEMBRANE	-0.000810076042012341	0.962617595166858	2145	Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein	sulfite transport	sulfite transmembrane transporter activity	integral to membrane|plasma membrane
YPR111W	DBF20	hom	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|SITE OF POLARIZED GROWTH|CYTOSKELETON	-0.000811562578817959	0.962515523097973	2146	Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs	cytokinesis after mitosis|protein phosphorylation|barrier septum assembly involved in cell cycle cytokinesis|regulation of mRNA catabolic process|exit from mitosis	protein serine/threonine kinase activity	spindle pole body|cellular bud neck|cytoplasm
YPL146C	NOP53	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.000811937993965665	0.9624981961774	2147	Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired	ribosomal large subunit export from nucleus|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rRNA binding	nucleolus|nucleus
YJR046W	TAH11	het	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|NUCLEUS	-0.000812219594085952	0.962485199209683	2148	DNA replication licensing factor, required for pre-replication complex assembly	regulation of DNA-dependent DNA replication initiation|double-strand break repair via break-induced replication|pre-replicative complex assembly	DNA replication origin binding|ATP binding	pre-replicative complex|nucleus|cytoplasm
YHR081W	LRP1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION|NUCLEUS	-0.000815325071771345	0.962392398913971	2149	Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination	U5 snRNA 3'-end processing|nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear retention of pre-mRNA at the site of transcription|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	double-stranded RNA binding|double-stranded DNA binding	nuclear exosome (RNase complex)
YNR027W	BUD17	hom	FT	CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM|NUCLEUS	-0.000817100984394458	0.962259905181206	2150	Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)	pyridoxal phosphate biosynthetic process|cellular bud site selection	pyridoxal kinase activity	nucleus|cytoplasm
YNL024C_p	YNL024C	hom			-0.000817707276702244	0.962231922782118	2151	Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cytoplasm
YML089C_d	YML089C	hom			-0.000817910069134088	0.962222563249767	2152	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage	Unknown	Unknown	Unknown
YPR110C	RPC40	het	FT	NUCLEUS	-0.000820387677867905	0.962108213943916	2153	RNA polymerase subunit AC40, common to RNA polymerase I and III	tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex
YDR187C_d	YDR187C	het	FF		-0.000821527720747451	0.962055597700664	2154	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W	Unknown	Unknown	Unknown
YKL204W	EAP1	hom	FT	TRANSLATION	-0.000823532028505779	0.961963093559177	2155	eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade	negative regulation of translation	eukaryotic initiation factor 4E binding	mRNA cap binding complex|cytoplasmic stress granule
YAL032C	PRP45	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEUS	-0.000824771885146781	0.961905871129005	2156	Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene	generation of catalytic spliceosome for second transesterification step	first spliceosomal transesterification activity|second spliceosomal transesterification activity	nucleus|post-mRNA release spliceosomal complex|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YIL058W_d	YIL058W	hom			-0.000827714634172947	0.96177005681722	2157	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL129C	MYO3	hom	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON	-0.000827955771602414	0.961781723852601	2158	One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization	bipolar cellular bud site selection|fungal-type cell wall organization|endocytosis|exocytosis|actin cortical patch localization|response to osmotic stress	microfilament motor activity	actin cortical patch
YAL028W	FRT2	hom	FT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000828103079240291	0.961752129309481	2159	Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication	response to stress	molecular_function	endoplasmic reticulum
YBL002W	HTB2	hom	FT	CHROMATIN ORGANIZATION|NUCLEUS|CHROMOSOME	-0.000829162493973476	0.961703235323563	2160	Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation	chromatin assembly or disassembly	DNA binding	replication fork protection complex|nuclear nucleosome
YOL163W_p	YOL163W	hom			-0.000829967001725867	0.96166610587123	2161	Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family	transmembrane transport	transmembrane transporter activity	integral to membrane|membrane
YEL002C	WBP1	het	FT	CELL CYCLE|CARBOHYDRATE METABOLISM|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	-0.000830679627463618	0.96163893343042	2162	Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum	cell cycle|protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	nuclear envelope|oligosaccharyltransferase complex|endoplasmic reticulum
YLL019C	KNS1	hom	FT	PROTEIN PHOSPHORYLATION	-0.000831075913543421	0.961614927770399	2163	Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation	negative regulation of transcription from RNA polymerase III promoter|protein autophosphorylation|protein phosphorylation	protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity	nucleus|cytoplasm
YMR304W	UBP15	hom	FT	PROTEOLYSIS	-0.00083109056074278	0.961637133896248	2164	Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p	protein deubiquitination	ubiquitin-specific protease activity	peroxisome|cytoplasm
YHR192W	LNP1	hom			-0.000832029640456193	0.961570911834134	2165	Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS	endoplasmic reticulum tubular network organization	molecular_function	endoplasmic reticulum tubular network|cytoplasm
YLR196W	PWP1	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.00083229781599717	0.961558535149306	2166	Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily	rRNA processing	molecular_function	nucleolus|nucleus|cytoplasm
YJR133W	XPT1	hom	FT	NUCLEOTIDE METABOLISM	-0.000832611837908201	0.961566966505341	2167	Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine	XMP salvage|hypoxanthine metabolic process	xanthine phosphoribosyltransferase activity|hypoxanthine phosphoribosyltransferase activity	cytoplasm
YPR118W	MRI1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	-0.000833646504690169	0.961496291377336	2168	5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway	L-methionine salvage from methylthioadenosine	S-methyl-5-thioribose-1-phosphate isomerase activity	nucleus|cytoplasm
YML042W	CAT2	hom	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|MITOCHONDRION	-0.000834147340268153	0.961473177210855	2169	Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes	carnitine metabolic process	carnitine O-acetyltransferase activity	mitochondrion|peroxisomal matrix|peroxisome
YGL208W	SIP2	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PLASMA MEMBRANE	-0.000834287857512637	0.961466692176218	2170	One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane	cellular response to glucose starvation|signal transduction|protein phosphorylation|replicative cell aging|invasive growth in response to glucose limitation|regulation of protein complex assembly	AMP-activated protein kinase activity	AMP-activated protein kinase complex|plasma membrane|cytoplasm
YOR060C	SLD7	het	FT	CELL CYCLE|ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|CYTOSKELETON	-0.000834441440682586	0.961459604136805	2171	Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria	regulation of DNA-dependent DNA replication initiation	molecular_function	nuclear envelope|endoplasmic reticulum|DNA replication preinitiation complex|nucleus|spindle pole body|cytoplasm
YGL128C	CWC23	het	FT	RNA PROCESSING|NUCLEUS	-0.000834975259678958	0.961440713718684	2172	Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p	spliceosomal complex disassembly	molecular_function	U2-type spliceosomal complex
YGR049W	SCM4	hom	FT	MITOCHONDRION	-0.000835402694582038	0.961415241236224	2173	Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to membrane
YKL003C	MRP17	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	-0.000836116877407711	0.961382281008554	2174	Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YMR314W	PRE5	het	FT	PROTEOLYSIS|ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	-0.00083612980199099	0.961410462350427	2175	Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YAL060W	BDH1	hom	FT	OXIDATION-REDUCTION PROCESS	-0.00083724196207228	0.961330357397728	2176	NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source	alcohol metabolic process|butanediol biosynthetic process	(R,R)-butanediol dehydrogenase activity	cytoplasm
YDL236W	PHO13	hom	FT	NUCLEUS	-0.000839380518687873	0.961231661649574	2177	Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity	protein dephosphorylation	4-nitrophenylphosphatase activity|phosphoprotein phosphatase activity|alkaline phosphatase activity	nucleus|cytoplasm
YGL017W	ATE1	hom	FT	PROTEOLYSIS	-0.00083964032268429	0.961219671570301	2178	Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway	cellular protein modification process|protein arginylation	arginyltransferase activity	cytoplasm
YPR140W	TAZ1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	-0.00084024111282474	0.961203509852107	2179	Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome	cardiolipin acyl-chain remodeling|mitochondrial ATP synthesis coupled electron transport|protein complex assembly|inner mitochondrial membrane organization|cardiolipin metabolic process|phospholipid biosynthetic process	1-acylglycerophosphocholine O-acyltransferase activity	mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YOL070C	NBA1	hom	FT	SITE OF POLARIZED GROWTH	-0.000840885371080909	0.961167998601906	2180	Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate	biological_process	molecular_function	ribosome|cellular bud neck|cytoplasm
YKL116C	PRR1	hom	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION	-0.000843243906213915	0.961053365364221	2181	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor	negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation	protein kinase activity|receptor signaling protein serine/threonine kinase activity	cytoplasm
YGL058W	RAD6	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEOLYSIS|GENE SILENCING|NUCLEUS|CHROMOSOME	-0.000844327007480253	0.96100338032321	2182	Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p	protein ubiquitination involved in ubiquitin-dependent protein catabolic process|histone monoubiquitination|protein monoubiquitination|error-free translesion synthesis|error-prone translesion synthesis|transcription from RNA polymerase II promoter|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of dipeptide transport|meiotic DNA double-strand break formation|ubiquitin-dependent protein catabolic process via the N-end rule pathway|double-strand break repair via homologous recombination|protein polyubiquitination|error-free postreplication DNA repair|chromatin silencing at telomere	ubiquitin-protein ligase activity	nuclear chromatin|proteasome complex|nucleus|cytoplasm
YMR239C	RNT1	het	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|NUCLEUS	-0.000844663168587793	0.96098786654483	2183	Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes	U5 snRNA 3'-end processing|mRNA cleavage|chromatin organization|termination of RNA polymerase II transcription, exosome-dependent|U4 snRNA 3'-end processing|U1 snRNA 3'-end processing|rRNA transcription|rRNA processing	ribonuclease III activity	nucleoplasm|nucleolus
YLR112W_d	YLR112W	hom			-0.000845735176425986	0.960938393662667	2184	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR221C	RSA3	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	-0.000846265766552673	0.960913907122306	2185	Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus	ribosomal large subunit assembly	molecular_function	nucleolus|preribosome, large subunit precursor
YOR186W_p	YOR186W	hom			-0.000847683465388073	0.960848481020225	2186	Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YBR080C	SEC18	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|SITE OF POLARIZED GROWTH	-0.00084968441513019	0.960756138625049	2187	ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF	Golgi vesicle docking|SNARE complex disassembly|Golgi to plasma membrane protein transport|vesicle fusion with Golgi apparatus|vacuole fusion, non-autophagic|inter-Golgi cisterna vesicle-mediated transport|autophagic vacuole assembly	ATPase activity	mating projection tip|cytoplasm
YGR127W_p	YGR127W	hom			-0.000850422398716519	0.96072208134472	2188	Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response	biological_process	molecular_function	cellular_component
YPR156C	TPO3	hom	FT	PLASMA MEMBRANE	-0.000852387647306376	0.960643119016711	2189	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication	spermine transport	spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YPR199C	ARR1	hom	FT	TRANSCRIPTION FROM RNA POL II|NUCLEUS	-0.000852692925992474	0.960617298997825	2190	Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds	positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YML130C	ERO1	het	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000853060611028926	0.960600330800043	2191	Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds	protein folding|protein thiol-disulfide exchange	thiol oxidase activity	endoplasmic reticulum
YPL143W	RPL33A	het	FT	TRANSLATION|RIBOSOME	-0.000855030760778181	0.960568286782954	2192	Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBL028C	YBL028C	hom	FT	NUCLEUS	-0.000856313342279542	0.960450222158929	2193	Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YJR131W	MNS1	hom	FT	CARBOHYDRATE METABOLISM|PROTEOLYSIS|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000856447508915147	0.960444030601119	2194	Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation	ER-associated protein catabolic process|protein deglycosylation involved in glycoprotein catabolic process	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum
YLR003C	CMS1	hom	FT	NUCLEUS	-0.000857268739531954	0.960406132282798	2195	Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress	biological_process	molecular_function	nucleus|90S preribosome
YIL118W	RHO3	het	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|PLASMA MEMBRANE	-0.000857471767282767	0.960396762930451	2196	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p	positive regulation of formin-nucleated actin cable assembly|establishment or maintenance of actin cytoskeleton polarity|positive regulation of exocytosis	GTP binding|GTPase activity	cytosol|plasma membrane|cellular bud
YLL034C	RIX7	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEUS	-0.000858633052976109	0.960343171864931	2197	Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions	ribosomal large subunit biogenesis|ribosomal large subunit export from nucleus	ATPase activity	nucleolus|nucleus|preribosome, large subunit precursor
YGR185C	TYS1	het	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEUS	-0.000860162685054737	0.960290341727466	2198	Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress	tyrosyl-tRNA aminoacylation	tyrosine-tRNA ligase activity	nucleus|cytoplasm
YMR303C	ADH2	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	-0.000861223045684276	0.960223649408048	2199	Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1	ethanol metabolic process|NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	cytoplasm
YOR283W	YOR283W	hom	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS	-0.000862293602373735	0.960174245836495	2200	Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene	dephosphorylation	phosphatase activity	nucleus|cytoplasm
YOL153C	YOL153C	hom			-0.000863559238835916	0.960115840008003	2201	Hypothetical protein	biological_process	molecular_function	cellular_component
YLR215C	CDC123	het	FT	CELL CYCLE|TRANSLATION|CELL DIVISION	-0.000864352243523888	0.960085192592975	2202	Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein	regulation of mitotic cell cycle|regulation of translation	molecular_function	cytoplasm
YDL188C	PPH22	hom	FT	CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|NUCLEUS|CHROMOSOME	-0.00086462542069074	0.960090441808806	2203	Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication	actin filament organization|budding cell bud growth|G1/S transition of mitotic cell cycle|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|regulation of translation	protein serine/threonine phosphatase activity	condensed nuclear chromosome, centromeric region
YDR254W	CHL4	hom	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|KINETOCHORE	-0.000866366054968827	0.959986313513044	2204	Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15	kinetochore assembly|chromosome segregation|establishment of meiotic sister chromatid cohesion|protein localization to chromosome, centromeric region|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	structural molecule activity	condensed nuclear chromosome outer kinetochore
YGR044C	RME1	hom	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|NUCLEUS	-0.000866796284839463	0.959966459734655	2205	Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription during meiosis|negative regulation of meiosis|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YDR340W_d	YDR340W	hom			-0.000866920127392389	0.959960744788321	2206	Putative protein of unknown function	Unknown	Unknown	Unknown
YDR056C_p	YDR056C	hom	FT	ENDOPLASMIC RETICULUM	-0.000866963684021728	0.959958734786648	2207	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein	biological_process	molecular_function	endoplasmic reticulum
YJR021C	REC107	hom	FT	CELL CYCLE|NUCLEUS|CHROMOSOME	-0.000867617272565918	0.959928573758202	2208	Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation	reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YNR024W	MPP6	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.000873003674320318	0.95969803423626	2209	Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes	nuclear mRNA surveillance of spliceosomal pre-mRNA splicing|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	poly(U) RNA binding	ribosome|nucleus|nuclear exosome (RNase complex)|TRAMP complex
YBR262C	AIM5	hom	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION	-0.000873235757625516	0.959669300946987	2210	Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YCR060W	TAH1	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEUS	-0.000873283429725716	0.959667101069791	2211	Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II	protein folding|box C/D snoRNP assembly	chaperone binding	R2TP complex|nucleus|cytoplasm
YDR498C	SEC20	het	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	-0.000876062020457178	0.95955093752125	2212	Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p	retrograde vesicle-mediated transport, Golgi to ER|vesicle fusion with endoplasmic reticulum	SNAP receptor activity	SNARE complex|integral to membrane|endoplasmic reticulum|peroxisome
YJR149W_p	YJR149W	hom	FT	OXIDATION-REDUCTION PROCESS	-0.000876892406351829	0.959518665736818	2213	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YHR093W_d	AHT1	hom			-0.000876997489916925	0.959495712957344	2214	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region	Unknown	Unknown	Unknown
YLR017W	MEU1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEUS	-0.000877304163194094	0.95948156137089	2215	Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression	L-methionine salvage from methylthioadenosine|glutamate biosynthetic process	S-methyl-5-thioadenosine phosphorylase activity|mRNA binding	cytoplasm
YPR155C	NCA2	hom	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|MITOCHONDRION	-0.000877731061125641	0.959461861980958	2216	Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p	mRNA metabolic process|aerobic respiration	molecular_function	mitochondrial outer membrane|mitochondrion
YKL081W	TEF4	hom	FT	TRANSLATION|MITOCHONDRION|RIBOSOME	-0.000877857837091824	0.959456011853859	2217	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex	translational elongation	translation elongation factor activity	mitochondrion|ribosome|eukaryotic translation elongation factor 1 complex
YGR084C	MRP13	hom	FT	TRANSLATION|MITOCHONDRION ORGANIZATION|MITOCHONDRION|RIBOSOME	-0.000880160165268041	0.959392181926482	2218	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YMR094W	CTF13	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|NUCLEUS|CHROMOSOME|KINETOCHORE	-0.00088221845078666	0.959254790940941	2219	Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis	kinetochore assembly|septin ring assembly	DNA binding, bending|centromeric DNA binding	condensed nuclear chromosome kinetochore|CBF3 complex
YJL118W	YJL118W	hom			-0.000885016812488668	0.959125661653445	2220	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein	biological_process	molecular_function	ribosome
YOR308C	SNU66	hom	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEUS	-0.000885210656635924	0.959116716832046	2221	Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1	maturation of 5S rRNA|mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YGR140W	CBF2	het	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION|NUCLEUS|CHROMOSOME|CYTOSKELETON|KINETOCHORE	-0.000885998617335088	0.959080356913243	2222	Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; relative distribution to the spindle pole body decreases upon DNA replication stress	chromosome segregation|septin ring assembly|mitotic spindle elongation	DNA binding, bending|centromeric DNA binding	spindle midzone|condensed nuclear chromosome kinetochore|CBF3 complex|condensed nuclear chromosome, centromeric region|spindle
YDR534C	FIT1	hom	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	-0.000887616373767638	0.959005706892756	2223	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall	siderophore transport	molecular_function	fungal-type cell wall
YBR205W	KTR3	hom	FT	CARBOHYDRATE METABOLISM	-0.000888387494978913	0.958976236806744	2224	Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress	N-glycan processing|protein O-linked glycosylation	mannosyltransferase activity	fungal-type vacuole
YMR030W	RSF1	hom	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|NUCLEUS|MITOCHONDRION	-0.000888401335224461	0.959006175114868	2225	Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes	transcription from mitochondrial promoter|calcium-mediated signaling|transcription from RNA polymerase II promoter|aerobic respiration	molecular_function	mitochondrion|nucleus
YGL138C_p	YGL138C	hom			-0.000888541845510326	0.958963001933067	2226	Putative protein of unknown function; has no significant sequence similarity to any known protein	biological_process	molecular_function	cellular_component
YDR321W	ASP1	hom	FT	KETONE METABOLISM|AMINO ACID METABOLISM	-0.000889043707519154	0.958939844066307	2227	Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively	asparagine catabolic proces