strainid	orf	gene	zyg	qualifier	SGTC_108|0509-0257.score	SGTC_108|0509-0257.expt.zyg.pval	SGTC_108|0509-0257.expt.zyg.significant	SGTC_108|0509-0257.expt.zyg.rank	strain.pval	strain.rank	clearance	Fclass	Fterms.BP	Fterms.CC	Fterms.complex	description	GO_process	GO_function	GO_component
YFL031W	YFL031W	HAC1	hom	Verified	17.723887239683	1.37143392732047e-70	yes	1	2.3873903697954e-76	7	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING	NUCLEUS		Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress	endoplasmic reticulum unfolded protein response|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|negative regulation of transcription from RNA polymerase II promoter during meiosis|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YHR205W	YHR205W	SCH9	hom	Verified	9.29503453920029	7.35792070051399e-21	yes	2	1.46608938249831e-22	5	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|CHROMOSOME		AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan	protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|regulation of protein localization|positive regulation of transcription from RNA polymerase III promoter|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase I promoter|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of cell size|regulation of response to osmotic stress	protein serine/threonine kinase activity	chromatin|fungal-type vacuole membrane|nucleus|cytoplasm
YFL032W_d	YFL032W	YFL032W	hom	Dubious	9.29266589765093	7.52356770437496e-21	yes	3	1.07972115735189e-18	14	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene	Unknown	Unknown	Unknown
YDR466W	YDR466W	PKH3	hom	Verified	8.91533243245537	2.43177481218615e-19	yes	4	1.14233475460476e-12	7	NA	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION			Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant	MAPK cascade involved in cell wall biogenesis|protein phosphorylation	protein kinase activity	cellular_component
YDR359C	YDR359C	EAF1	hom	Verified	7.96683572514319	8.13944157866283e-16	yes	5	5.02535710241351e-15	1	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1	DNA repair|cellular protein complex assembly|chromatin modification	molecular_function	histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YHR030C	YHR030C	SLT2	hom	Verified	7.67697025891971	8.14476153563374e-15	yes	6	5.14602439129033e-08	104	NA	FF|FT	PROTEIN LOCALIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH		Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway	protein phosphorylation|endoplasmic reticulum unfolded protein response|signal transduction|UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|regulation of transcription factor import into nucleus|barrier septum assembly|response to acid|regulation of cell size	MAP kinase activity|protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm|cellular bud tip
YGL042C_d	YGL042C	YGL042C	hom	Dubious	7.38709212290837	7.50373127826427e-14	yes	7	6.85936486703485e-14	2	NA					Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1	Unknown	Unknown	Unknown
YGR014W	YGR014W	MSB2	hom	Verified	6.97397031999618	1.54059556743307e-12	yes	8	1.11779646633933e-09	1	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate	signal transduction involved in filamentous growth|osmosensory signaling pathway via Sho1 osmosensor|establishment of cell polarity|hyperosmotic response|response to osmotic stress	osmosensor activity	site of polarized growth|integral to plasma membrane
YHR004C	YHR004C	NEM1	hom	Verified	6.45942220089422	5.25517513761972e-11	yes	9	6.39489977190451e-10	28	NA	FF|FT	LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|mitochondrion|integral to membrane
YHR079C	YHR079C	IRE1	hom	Verified	6.23429454382507	2.26909251524043e-10	yes	10	3.58909726622872e-09	34	NA	FF|FT	RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress	endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|inositol metabolic process|protein phosphorylation	unfolded protein binding|protein serine/threonine kinase activity|endoribonuclease activity|protein kinase activity|protein homodimerization activity	nucleus
YGL005C	YGL005C	COG7	hom	Verified	6.17029570842283	3.408119634476e-10	yes	11	0.000893754073516134	77	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	mitochondrion|Golgi transport complex
YGR130C	YGR130C	YGR130C	hom	Verified	6.1372393294713	4.19839196182478e-10	yes	12	9.27868134140294e-09	1	NA					Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)	biological_process	molecular_function	eisosome|membrane raft|cytoplasm
YGL115W	YGL115W	SNF4	hom	Verified	6.05434030440351	7.04971335750176e-10	yes	13	3.55028008014696e-08	10	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE		Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress	positive regulation of gluconeogenesis|peroxisome organization|protein phosphorylation|replicative cell aging|regulation of transcription from RNA polymerase II promoter	AMP-activated protein kinase activity|protein serine/threonine kinase activator activity	AMP-activated protein kinase complex|plasma membrane|nucleus|nuclear envelope lumen|cytoplasm
YDR173C	YDR173C	ARG82	hom	Verified	5.68097122248464	6.69660065469825e-09	yes	14	3.73560955500396e-08	11	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes	protein stabilization|negative regulation of transcription from RNA polymerase II promoter|phosphatidylinositol phosphorylation|regulation of arginine metabolic process|inositol phosphate biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	inositol-1,4,5-trisphosphate 3-kinase activity|inositol-1,4,5-trisphosphate 6-kinase activity|phosphatidylinositol 3-kinase activity|protein binding, bridging|inositol tetrakisphosphate 6-kinase activity|inositol tetrakisphosphate 3-kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity	nucleus
YDR346C	YDR346C	SVF1	hom	Verified	5.62472527405752	9.29017181013995e-09	yes	15	1.33725458204309e-07	6	NA	FT	RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance	cellular response to oxidative stress	molecular_function	nucleus|cytoplasm
YHR059W	YHR059W	FYV4	hom	Verified	5.57053979557899	1.26975650488376e-08	yes	16	6.72095842515585e-09	3	NA	FT		MITOCHONDRION		Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	mitochondrion
YDR392W	YDR392W	SPT3	hom	Verified	5.50192380611293	1.87834655629452e-08	yes	17	1.30728901380506e-05	67	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters	conjugation with cellular fusion|histone acetylation|pseudohyphal growth|ascospore formation|chromatin modification|invasive growth in response to glucose limitation|transcription from RNA polymerase II promoter	transcription cofactor activity	SLIK (SAGA-like) complex|SAGA complex
YEL044W	YEL044W	IES6	hom	Verified	5.35467537892221	4.2855076399914e-08	yes	18	3.11669212949248e-07	14	NA	FT		NUCLEUS		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes	biological_process	molecular_function	nucleus
YDR360W_d	YDR360W	OPI7	hom	Dubious	5.28620222924822	6.2440916592333e-08	yes	19	9.63543264273668e-08	11	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.	Unknown	Unknown	Unknown
YPR149W	YPR149W	NCE102	hom	Verified	5.24753503944225	7.70738691738698e-08	yes	20	1.08400695832068e-08	2	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)	eisosome assembly|protein secretion|negative regulation of protein phosphorylation|plasma membrane organization|establishment of protein localization to plasma membrane	molecular_function	mitochondrion|integral to membrane|membrane raft|endoplasmic reticulum|cellular bud membrane|plasma membrane|mating projection membrane|cytoplasm
YHL004W	YHL004W	MRP4	hom	Verified	5.23660048487589	8.17806050292252e-08	yes	21	1.24883441038287e-07	13	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome|tRNA binding	mitochondrion|mitochondrial small ribosomal subunit
YDL100C	YDL100C	GET3	hom	Verified	5.21325240183674	9.27790733894804e-08	yes	22	4.20151267009191e-05	40	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress	retrograde vesicle-mediated transport, Golgi to ER|pheromone-dependent signal transduction involved in conjugation with cellular fusion|response to heat|protein insertion into ER membrane|response to metal ion|posttranslational protein targeting to membrane	ATPase activity|guanyl-nucleotide exchange factor activity	endoplasmic reticulum|GET complex
YBL051C	YBL051C	PIN4	hom	Verified	5.00398260149758	2.80789139138149e-07	yes	23	2.54915997697215e-06	26	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE			Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage	G2/M transition of mitotic cell cycle|DNA damage checkpoint	molecular_function	cytoplasm
YBL079W	YBL079W	NUP170	hom	Verified	4.90256939670443	4.72955909431595e-07	yes	24	5.58047912595781e-06	34	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication	nucleocytoplasmic transport|chromosome segregation|protein targeting to nuclear inner membrane|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YHL011C	YHL011C	PRS3	hom	Verified	4.90220439803696	4.73835773308048e-07	yes	25	2.79823193053153e-06	25	NA	FF|FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process|regulation of cell size	ribose phosphate diphosphokinase activity	cytoplasm
YHR041C	YHR041C	SRB2	hom	Verified	4.77422193997535	9.02016736819515e-07	yes	26	1.52147545445579e-05	20	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding	core mediator complex
YDR495C	YDR495C	VPS3	hom	Verified	4.756655192968	9.84134677753349e-07	yes	27	2.5672270946349e-05	53	NA	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase	vacuole inheritance|vacuolar acidification|protein targeting to vacuole	molecular_function	CORVET complex|cytoplasm
YOR070C	YOR070C	GYP1	hom	Verified	4.73855351420871	1.07624593990844e-06	yes	28	0.00064053304303069	126	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|GOLGI APPARATUS		Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion	vesicle-mediated transport	Rab GTPase activator activity	mitochondrion|Golgi apparatus
YFL025C	YFL025C	BST1	hom	Verified	4.64892862245756	1.6683182249131e-06	yes	29	0.000115077113593111	50	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules	protein retention in ER lumen|vesicle organization|ER-associated protein catabolic process|ER to Golgi vesicle-mediated transport|GPI anchor metabolic process	phosphatidylinositol deacylase activity	integral to membrane|endoplasmic reticulum
YGL072C_d	YGL072C	YGL072C	hom	Dubious	4.64732237697281	1.68135714017863e-06	yes	30	3.32125625410831e-05	47	NA	FF				Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	Unknown	Unknown	Unknown
YKL002W	YKL002W	DID4	hom	Verified	4.63595464405215	1.7764693649949e-06	yes	31	8.06964841396189e-06	19	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis	protein retention in Golgi apparatus|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	molecular_function	ESCRT III complex|cytoplasm
YFL033C	YFL033C	RIM15	hom	Verified	4.61463043688653	1.96897698640479e-06	yes	32	1.21904497551496e-06	12	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase	protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|response to stress|regulation of meiosis	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YGL066W	YGL066W	SGF73	hom	Verified	4.55873583438025	2.57312267943751e-06	yes	33	1.80520636760369e-05	18	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RNA LOCALIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay	histone deubiquitination|mRNA export from nucleus|histone acetylation|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|protein complex assembly|chromatin modification	histone acetyltransferase activity|enzyme activator activity|structural molecule activity	DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YDR483W	YDR483W	KRE2	hom	Verified	4.522750377583	3.05206068640466e-06	yes	34	5.97079901191651e-05	12	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication	N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YGL095C	YGL095C	VPS45	hom	Verified	4.50734913417072	3.28212863799602e-06	yes	35	0.0013267965811409	109	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment	vacuole inheritance|CVT pathway|positive regulation of SNARE complex assembly|Golgi vesicle fusion to target membrane|Golgi to vacuole transport|vacuole organization|vacuolar acidification|protein targeting to vacuole|Golgi to endosome transport	unfolded protein binding|SNARE binding	cytosol|SNARE complex|Golgi membrane|extrinsic to membrane
YDR120C	YDR120C	TRM1	hom	Verified	4.39505794492468	5.53716045574499e-06	yes	36	1.52949941012015e-05	35	NA	FT	RNA PROCESSING	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments	tRNA methylation	tRNA (guanine-N2-)-methyltransferase activity	mitochondrion|nuclear envelope|nuclear inner membrane
YBR111W-A	YBR111W-A	SUS1	hom	Verified	4.36644784389041	6.31417122999211e-06	yes	37	3.1333813150161e-05	19	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE|HISTONE ACETYLTRANSFERASE	Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP	poly(A)+ mRNA export from nucleus|regulation of protein localization|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone deubiquitination|histone H3-K4 methylation|transcription elongation from RNA polymerase II promoter|histone H3-K79 methylation|positive regulation of transcription from RNA polymerase II promoter	enzyme activator activity	DUBm complex|nucleoplasm|transcription export complex 2|SAGA complex|nuclear pore
YER083C	YER083C	GET2	hom	Verified	4.31004573372243	8.16103937073872e-06	yes	38	0.000781285527938503	66	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division	retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane	protein anchor	integral to membrane|endoplasmic reticulum|GET complex
YDR334W	YDR334W	SWR1	hom	Verified	4.29743800984437	8.63917797400478e-06	yes	39	0.000120896886617526	77	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A	chromatin remodeling|histone exchange	structural molecule activity	Swr1 complex|nucleus
YHR141C	YHR141C	RPL42B	hom	Verified	4.24912194097094	1.07305038263145e-05	yes	40	4.82647545549356e-05	11	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR207C	YDR207C	UME6	hom	Verified	4.24673398818595	1.08454617869679e-05	yes	41	0.000729588402571167	41	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|CHROMOSOME		Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p	spore germination|positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter during meiosis|lipid particle organization|nitrogen catabolite repression of transcription from RNA polymerase II promoter|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|repressing transcription factor binding|transcription factor binding transcription factor activity	Rpd3L-Expanded complex|Rpd3L complex
YOR043W	YOR043W	WHI2	hom	Verified	4.19933760944201	1.33848467050473e-05	yes	42	4.29592155408209e-06	5	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION			Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression	response to salt stress|mitochondrion degradation|actin filament organization|endocytosis|response to heat|regulation of growth|response to stress	phosphatase activator activity	cellular_component
YNL257C	YNL257C	SIP3	hom	Verified	4.18732265102781	1.41132212435145e-05	yes	43	4.37860463288433e-05	26	NA	FT	TRANSCRIPTION FROM RNA POL II			Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	transcription cofactor activity	integral to membrane
YDR378C	YDR378C	LSM6	hom	Verified	4.18548662493968	1.42277912390364e-05	yes	44	3.75135769925328e-05	45	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasmic mRNA processing body
YDR028C	YDR028C	REG1	hom	Verified	4.1790406673589	1.46370670057642e-05	yes	45	0.00205552800383682	121	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p	cellular response to glucose starvation|vacuolar protein catabolic process|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of carbohydrate metabolic process	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex|cytoplasm
YHR155W	YHR155W	YSP1	hom	Verified	4.1438235364707	1.70781306319256e-05	yes	46	4.91728649150041e-05	42	NA	FF|FT		MITOCHONDRION		Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion
YKL073W	YKL073W	LHS1	hom	Verified	4.1076407201012	1.9986062227174e-05	yes	47	0.00010084153859796	25	NA	FT	PROTEIN LOCALIZATION|NUCLEOTIDE METABOLISM	ENDOPLASMIC RETICULUM		Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway	posttranslational protein targeting to membrane, translocation|response to unfolded protein	unfolded protein binding|adenyl-nucleotide exchange factor activity|ATP binding	endoplasmic reticulum lumen
YGL258W	YGL258W	VEL1	hom	Verified	4.0619663753912	2.43305436799084e-05	yes	48	0.000161698389230278	23	NA					Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C	biological_process	molecular_function	cytosol
YGL248W	YGL248W	PDE1	hom	Verified	4.05584682473802	2.4976494549757e-05	yes	49	8.60219489405335e-06	5	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation	cAMP-mediated signaling	3',5'-cyclic-AMP phosphodiesterase activity	cellular_component
YDR222W_p	YDR222W	YDR222W	hom	Uncharacterized	4.04567003127949	2.60868401222536e-05	yes	50	0.000105444681965406	13	NA	FT	RESPONSE TO OXIDATIVE STRESS			Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YGR204W	YGR204W	ADE3	hom	Verified	3.97579308072164	3.5072548551318e-05	yes	51	7.70746093320156e-05	15	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine	purine nucleobase biosynthetic process|folic acid-containing compound metabolic process	methylenetetrahydrofolate dehydrogenase (NADP+) activity|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity	nucleus|cytoplasm
YDR372C	YDR372C	VPS74	hom	Verified	3.88912300142281	5.03035606516149e-05	yes	52	0.000214689963839978	62	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33	retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum unfolded protein response|protein localization to Golgi apparatus	enzyme binding|phosphatidylinositol-4-phosphate binding	cytosol|Golgi apparatus|nucleus|extrinsic to membrane|cytoplasm
YBR178W_d	YBR178W	YBR178W	hom	Dubious	3.87392805467636	5.35475205380801e-05	yes	53	8.23534625487558e-05	13	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C	Unknown	Unknown	Unknown
YBR231C	YBR231C	SWC5	hom	Verified	3.86005121935043	5.66816304078038e-05	yes	54	0.000915952226364671	86	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress	chromatin remodeling|histone exchange	molecular_function	Swr1 complex|nucleus
YDL023C_d	YDL023C	YDL023C	hom	Dubious	3.85334203998129	5.82582214758262e-05	yes	55	0.000111760138199872	17	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YGR146C	YGR146C	ECL1	hom	Verified	3.848865965261	5.93329560853456e-05	yes	56	7.24217641034456e-05	19	NA					Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	cellular_component
YDR237W	YDR237W	MRPL7	hom	Verified	3.80166032023134	7.18648446674202e-05	yes	57	0.000244953141633189	38	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YNL325C	YNL325C	FIG4	hom	Verified	3.75540399359044	8.65310464629349e-05	yes	58	0.00018642776853456	24	NA	FT	LIPID METABOLISM			Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	fungal-type vacuole membrane|PAS complex|extrinsic to membrane
YOL096C	YOL096C	COQ3	hom	Verified	3.72824469918227	9.64090546281381e-05	yes	59	8.46204845232586e-05	35	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein	ubiquinone biosynthetic process	hexaprenyldihydroxybenzoate methyltransferase activity	mitochondrion|mitochondrial inner membrane|extrinsic to membrane
YDR080W	YDR080W	VPS41	hom	Verified	3.72006485655086	9.95858124740127e-05	yes	60	0.000121757945856995	73	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING			Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole organization|vesicle-mediated transport|protein transport|vacuole fusion, non-autophagic|vacuolar protein processing	Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding	endosome|fungal-type vacuole membrane|HOPS complex
YDR451C	YDR451C	YHP1	hom	Verified	3.68935690021015	0.000112410821320074	yes	61	0.00100287825557506	41	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS|CHROMOSOME		Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nuclear chromatin|nucleus
YDR467C_d	YDR467C	YDR467C	hom	Dubious	3.67223142318086	0.000120220895707348	yes	62	0.000207976323527154	13	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML034W	YML034W	SRC1	hom	Verified	3.66095765270213	0.000125637145861044	yes	63	0.000514826082641016	74	NA	FF|FT	CELL CYCLE|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance	maintenance of rDNA|mitotic sister chromatid segregation	molecular_function	nuclear envelope
YGR087C	YGR087C	PDC6	hom	Verified	3.65553386395223	0.00012832366273462	yes	64	7.07650202926255e-05	10	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation	L-phenylalanine catabolic process|ethanol metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	pyruvate decarboxylase activity	cytoplasm
YNL135C	YNL135C	FPR1	hom	Verified	3.60084562297766	0.00015859193869221	yes	65	0.000373377097944298	29	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION		Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function	protein folding|chromatin organization|homoserine metabolic process	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	mitochondrion|nucleus|cytoplasm
YDR314C	YDR314C	RAD34	hom	Verified	3.59975692717559	0.000159257391982411	yes	66	6.53060175224591e-05	8	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in nucleotide excision repair (NER); homologous to RAD4	nucleotide-excision repair	molecular_function	nucleus
YDR281C	YDR281C	PHM6	hom	Verified	3.57541002665301	0.000174839710826512	yes	67	0.000549973980879211	28	NA					Protein of unknown function, expression is regulated by phosphate levels	biological_process	molecular_function	fungal-type vacuole
YGR062C	YGR062C	COX18	hom	Verified	3.50118170576844	0.000231599954781193	yes	68	0.000273001445224932	34	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC	protein insertion into mitochondrial membrane from inner side	membrane insertase activity	integral to membrane|integral to mitochondrial inner membrane
YBL037W	YBL037W	APL3	hom	Verified	3.48536951070492	0.000245728930373874	yes	69	0.00020147465071539	27	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YGR143W	YGR143W	SKN1	hom	Verified	3.39769499244855	0.000339780696418888	yes	70	0.000988668412665363	28	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p	fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process|sphingolipid biosynthetic process	glucosidase activity	integral to membrane
YDR231C	YDR231C	COX20	hom	Verified	3.39698070572576	0.00034066885400912	yes	71	0.000356255299498906	27	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase	mitochondrial respiratory chain complex IV assembly|protein processing|aerobic respiration	unfolded protein binding	mitochondrion|mitochondrial inner membrane
YGR166W	YGR166W	TRS65	hom	Verified	3.38217099343163	0.000359576825058291	yes	72	0.00117129572127044	63	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS	GOLGI APPARATUS		Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response	intra-Golgi vesicle-mediated transport|protein complex assembly	Rab guanyl-nucleotide exchange factor activity	TRAPP complex|trans-Golgi network
YDR204W	YDR204W	COQ4	hom	Verified	3.3736026772965	0.000370956855269044	yes	73	0.000187017766828893	46	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex	ubiquinone biosynthetic process	molecular_function	mitochondrial inner membrane
YMR256C	YMR256C	COX7	hom	Verified	3.33577161619854	0.000425315065120784	yes	74	0.0015464341277334	54	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YOR216C	YOR216C	RUD3	hom	Verified	3.32810180770414	0.000437199529426192	yes	75	0.000404200923344798	39	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	GOLGI APPARATUS		Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1	ER to Golgi vesicle-mediated transport	molecular_function	Golgi apparatus
YDR200C	YDR200C	VPS64	hom	Verified	3.32241245267271	0.000446213356226519	yes	76	0.00115781552753143	49	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance	re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole	molecular_function	endoplasmic reticulum membrane|cytoplasm
YDR276C	YDR276C	PMP3	hom	Verified	3.31075017458914	0.000465231189764753	yes	77	0.000493686649024353	39	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential	regulation of membrane potential|cation transport	molecular_function	plasma membrane
YGL168W	YGL168W	HUR1	hom	Verified	3.31068681711445	0.000465336528494803	yes	78	0.0030981894129163	85	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene	DNA replication	molecular_function	cellular_component
YLR052W	YLR052W	IES3	hom	Verified	3.29560350122574	0.00049105259480964	yes	79	0.000947264818728761	40	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the INO80 chromatin remodeling complex	nucleosome mobilization|telomere maintenance|chromatin silencing at telomere	molecular_function	nucleus|Ino80 complex
YKL096C-B_p	YKL096C-B	YKL096C-B	hom	Uncharacterized	3.24202150229313	0.000593425336663263	yes	80	0.00121632614747092	36	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YPR101W	YPR101W	SNT309	hom	Verified	3.20349251987194	0.000678857835038835	yes	81	0.00151091506751549	53	NA	FT	RNA PROCESSING	NUCLEUS		Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p	mRNA splicing, via spliceosome	first spliceosomal transesterification activity	Prp19 complex|U2-type catalytic step 1 spliceosome
YLR268W	YLR268W	SEC22	hom	Verified	3.19811108284524	0.000691654918105361	yes	82	0.0072528988474821	141	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion with endoplasmic reticulum|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle membrane
YGL054C	YGL054C	ERV14	hom	Verified	3.1392096517291	0.000847020999832735	yes	83	0.0226916618266167	214	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication	ascospore formation|ER to Golgi vesicle-mediated transport|axial cellular bud site selection	molecular_function	integral to membrane|ER to Golgi transport vesicle|endoplasmic reticulum membrane
YDR251W	YDR251W	PAM1	hom	Verified	3.1388137476272	0.000848166150613121	yes	84	0.000423962928288726	24	NA	FT	OXIDATION-REDUCTION PROCESS	SITE OF POLARIZED GROWTH		Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype	pseudohyphal growth	molecular_function	cellular bud|cellular bud neck
YPL254W	YPL254W	HFI1	hom	Verified	3.10129169685816	0.000963391911680256	yes	85	0.00178340435328304	51	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions	histone acetylation|chromatin modification|transcription from RNA polymerase II promoter	transcription coactivator activity|transcription cofactor activity	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YDR271C_d	YDR271C	YDR271C	hom	Dubious	3.09571433291595	0.00098169708435429	yes	86	0.00386586409606866	88	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W	Unknown	Unknown	Unknown
YDR315C	YDR315C	IPK1	hom	Verified	3.06426787080729	0.00109101718253915	no	87	0.00481420940094242	56	NA	FT		NUCLEUS		Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable	nuclear-transcribed mRNA catabolic process, non-stop decay|inositol phosphate biosynthetic process	inositol pentakisphosphate 2-kinase activity	nucleus
YDR322W	YDR322W	MRPL35	hom	Verified	3.05836447203159	0.00111274359751255	no	88	0.00261521622321013	44	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YFL023W	YFL023W	BUD27	hom	Verified	3.04092312944167	0.00117927018581589	no	89	0.00141582717613234	85	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION		RIBOSOME	Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP	formation of translation preinitiation complex	molecular_function	cytosolic ribosome|cytoplasm
YGR168C_p	YGR168C	YGR168C	hom	Uncharacterized	3.01396497672542	0.0012892878567052	no	90	0.00452079425235507	52	NA					Putative protein of unknown function; YGR168C is not an essential gene	biological_process	molecular_function	integral to membrane
YNR045W	YNR045W	PET494	hom	Verified	2.99747467339769	0.0013611323862927	no	91	0.000692025374470961	32	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrion|mitochondrial inner membrane
YDR540C	YDR540C	IRC4	hom	Verified	2.99715967596128	0.00136253968334073	no	92	0.00604486355902755	107	NA	FF|FT		NUCLEUS		Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	mitotic recombination	molecular_function	nucleus|cytoplasm
YER141W	YER141W	COX15	hom	Verified	2.97907425890457	0.00144560350265743	no	93	0.00073749737860256	35	NA	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase	heme a biosynthetic process	oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor	mitochondrion|integral to membrane|mitochondrial inner membrane
YEL029C	YEL029C	BUD16	hom	Verified	2.9423459498748	0.00162867903796838	no	94	0.00837554324376802	92	NA	FT	CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM	NUCLEUS		Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)	pyridoxal phosphate biosynthetic process|cellular bud site selection	pyridoxal kinase activity	cytoplasm
YMR165C	YMR165C	PAH1	hom	Verified	2.94188640187683	0.00163109786114506	no	95	0.00264026087075961	58	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2	plasmid maintenance|vacuole fusion, non-autophagic|lipid particle organization|aerobic respiration|phospholipid biosynthetic process	phosphatidate phosphatase activity	cytosol|nuclear membrane|vacuole|cytoplasm|extrinsic to membrane
YDR486C	YDR486C	VPS60	hom	Verified	2.94144427100968	0.00163342809812633	no	96	0.00240106075322261	48	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p	late endosome to vacuole transport via multivesicular body sorting pathway|filamentous growth	molecular_function	fungal-type vacuole membrane|cytoplasm
YDR270W	YDR270W	CCC2	hom	Verified	2.9410522956771	0.00163549652777254	no	97	0.00389432418645333	104	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism	cellular iron ion homeostasis|copper ion export|transmembrane transport	copper ion binding|cation-transporting ATPase activity	integral to membrane|trans-Golgi network transport vesicle membrane
YGL049C	YGL049C	TIF4632	hom	Verified	2.94094489547149	0.00163606368835419	no	98	0.000535492474233936	21	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION		RIBOSOME	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication	translational initiation|stress granule assembly	translation initiation factor binding|mRNA binding|translation initiation factor activity	eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YBR194W	YBR194W	AIM4	hom	Verified	2.93978956961959	0.0016421760906291	no	99	0.0051623645463163	57	NA					Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress	biological_process	molecular_function	cytoplasm
YDR516C	YDR516C	EMI2	hom	Verified	2.9221883902947	0.00173790615798281	no	100	0.00207326429329451	55	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YNL315C	YNL315C	ATP11	hom	Verified	2.9189406534532	0.00175611541130379	no	101	0.00169698143507571	81	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase	mitochondrion organization|mitochondrial proton-transporting ATP synthase complex assembly	unfolded protein binding	mitochondrion|mitochondrial matrix
YGR037C	YGR037C	ACB1	hom	Verified	2.9176954405556	0.00176314292966838	no	102	0.0180955677245346	213	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	NUCLEUS		Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress	long-chain fatty acid transport|chronological cell aging|fatty acid metabolic process	long-chain fatty acid transporter activity|fatty-acyl-CoA binding	extracellular region|nucleus|cytoplasm
YJR154W_p	YJR154W	YJR154W	hom	Uncharacterized	2.91626087187074	0.00177127081549432	no	103	0.000796594902164009	26	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YGR071C	YGR071C	ENV11	hom	Verified	2.91313358954279	0.00178910744514461	no	104	0.000693987344536134	29	NA	FT	VACUOLAR PROTEIN PROCESSING	NUCLEUS		Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	vacuole organization|vacuolar protein processing	molecular_function	nucleus
YJL209W	YJL209W	CBP1	hom	Verified	2.90143969556607	0.00185726133396344	no	105	0.00167785525795387	61	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress	mitochondrial mRNA catabolic process|aerobic respiration	mRNA binding	mitochondrion|extrinsic to mitochondrial inner membrane
YDL118W_d	YDL118W	YDL118W	hom	Dubious	2.89923771203348	0.00187035586290244	no	106	0.00618808030804002	148	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein	biological_process	molecular_function	cellular_component
YBR185C	YBR185C	MBA1	hom	Verified	2.89850479047526	0.00187473290444064	no	107	0.00132030644174373	36	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane	protein insertion into mitochondrial membrane from inner side|mitochondrial respiratory chain complex III biogenesis|inner mitochondrial membrane organization|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	ribosome binding	mitochondrion|mitochondrial inner membrane
YHR176W	YHR176W	FMO1	hom	Verified	2.89306167681237	0.00190753186604773	no	108	0.00171915136375818	60	NA	FT	OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins	protein folding	N,N-dimethylaniline monooxygenase activity	endoplasmic reticulum membrane
YIL110W	YIL110W	HPM1	hom	Verified	2.88841649125095	0.00193593411850241	no	109	0.00310830763370735	60	NA	FT		NUCLEUS		AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance	peptidyl-histidine methylation, to form tele-methylhistidine	S-adenosylmethionine-dependent methyltransferase activity|protein-histidine N-methyltransferase activity	nucleus|cytoplasm
YDR195W	YDR195W	REF2	hom	Verified	2.87534938218805	0.00201790322303701	no	110	0.00385352767178875	56	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes	mRNA 3'-end processing|termination of RNA polymerase II transcription, poly(A)-coupled|snoRNA 3'-end processing|Unknown	chromatin binding|RNA binding	mRNA cleavage and polyadenylation specificity factor complex|nucleus
YOR085W	YOR085W	OST3	hom	Verified	2.87107866956111	0.00204536852730607	no	111	0.00187486629705378	51	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins	protein glycosylation|protein complex assembly|protein O-linked mannosylation|protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex|integral to membrane
YNL136W	YNL136W	EAF7	hom	Verified	2.86822401018968	0.00206391579200565	no	112	0.00572704523091751	104	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A	DNA repair|histone acetylation|regulation of transcription from RNA polymerase II promoter	molecular_function	histone acetyltransferase complex|nucleus|NuA4 histone acetyltransferase complex
YHR009C_p	YHR009C	TDA3	hom	Uncharacterized	2.86527981464696	0.0020832045359143	no	113	0.00299084074193095	67	NA	FT	VESICLE-MEDIATED TRANSPORT|OXIDATION-REDUCTION PROCESS			Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1	retrograde transport, endosome to Golgi	molecular_function	late endosome|cytoplasm
YOR330C	YOR330C	MIP1	hom	Verified	2.85831076246671	0.00212951529855929	no	114	0.000682724424503468	34	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit	mitochondrial DNA replication	3'-5' exonuclease activity|DNA-directed DNA polymerase activity	mitochondrion
YGR081C	YGR081C	SLX9	hom	Verified	2.82625706611959	0.00235477260368216	no	115	0.00530913480054383	66	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	preribosome, small subunit precursor|nucleolus|nucleus|90S preribosome
YDR385W	YDR385W	EFT2	hom	Verified	2.81892648016859	0.00240922765624727	no	116	0.00158581099085536	49	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication	translational elongation|positive regulation of translational elongation	translation elongation factor activity	ribosome
YDR293C	YDR293C	SSD1	hom	Verified	2.81434042260627	0.00244387189902053	no	117	0.0464610783620835	335	NA	FF|FT	CELL CYCLE|TRANSLATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|RNA LOCALIZATION	NUCLEUS|SITE OF POLARIZED GROWTH		Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function	regulation of fungal-type cell wall organization|negative regulation of translation|intracellular mRNA localization	mRNA binding|mRNA 5'-UTR binding|translation repressor activity, nucleic acid binding	nucleus|cellular bud|cytoplasmic stress granule|cytoplasmic mRNA processing body|cellular bud neck|cytoplasm
YDR278C_d	YDR278C	YDR278C	hom	Dubious	2.80842125219677	0.00248925283132285	no	118	0.00130719327400403	30	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL023C	YNL023C	FAP1	hom	Verified	2.80649637008634	0.00250417383770833	no	119	0.000691945265309334	23	NA	FT		NUCLEUS		Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1	biological_process	sequence-specific DNA binding transcription factor activity	cytoplasm
YOL054W	YOL054W	PSH1	hom	Verified	2.80536155983079	0.00251300833228868	no	120	0.00356061853247289	63	NA	FT	PROTEOLYSIS	NUCLEUS|CHROMOSOME		E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	chromosome, centromeric region|nucleus
YAL009W	YAL009W	SPO7	hom	Verified	2.7781778478582	0.00273323445377026	no	121	0.0061990885545028	136	NA	FF|FT	CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|integral to membrane
YLR125W_p	YLR125W	YLR125W	hom	Uncharacterized	2.75599319207722	0.00292571074382823	no	122	0.0029754116297811	63	NA					Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene	biological_process	molecular_function	cellular_component
YGR144W	YGR144W	THI4	hom	Verified	2.74864919768157	0.00299206967988852	no	123	0.00540728903554404	67	NA	FT	MITOCHONDRION ORGANIZATION	NUCLEUS		Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents	thiamine biosynthetic process|mitochondrial genome maintenance|thiazole biosynthetic process	ferrous iron binding	cytosol
YOL073C	YOL073C	YOL073C	hom	Verified	2.74350828520095	0.00303932571205661	no	124	0.00260462166142717	55	NA					Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2	biological_process	molecular_function	integral to membrane
YKL126W	YKL126W	YPK1	hom	Verified	2.74222490459011	0.00305122711530661	no	125	0.0847582255073702	502	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication	eisosome assembly|protein autophosphorylation|negative regulation of phospholipid translocation|protein phosphorylation	protein serine/threonine kinase activity	cytosol|plasma membrane|cellular bud neck
YDR285W	YDR285W	ZIP1	hom	Verified	2.73446411816257	0.00312409524722536	no	126	0.00349734540119382	48	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate	synapsis|reciprocal meiotic recombination	chromatin binding|SUMO polymer binding	transverse filament
YGR122W	YGR122W	YGR122W	hom	Verified	2.72846801969732	0.00318146297914476	no	127	0.00992301344779222	195	NA	FF|FT	TRANSCRIPTION FROM RNA POL II			Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	cytoplasm
YDL183C	YDL183C	YDL183C	hom	Verified	2.71920428725313	0.00327195892410796	no	128	0.00600035230010596	68	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene	potassium ion transport|proton transport	molecular_function	integral to mitochondrial inner membrane
YDL169C	YDL169C	UGX2	hom	Verified	2.7072272177978	0.00339239015015867	no	129	0.00292018369029912	42	NA					Protein of unknown function, transcript accumulates in response to any combination of stress conditions	biological_process	molecular_function	cellular_component
YDL032W_d	YDL032W	YDL032W	hom	Dubious	2.70495792407414	0.00341565208319841	no	130	0.00626523134808272	107	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene	Unknown	Unknown	Unknown
YDL115C	YDL115C	IWR1	hom	Verified	2.70373887191336	0.00342820735507518	no	131	0.00413762161980059	101	NA	FT	PROTEIN LOCALIZATION	NUCLEUS	RNA POL II, HOLOENZYME	RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress	cellular protein complex localization|nucleocytoplasmic transport	protein binding	nucleus|DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YJR083C	YJR083C	ACF4	hom	Verified	2.6976347855618	0.00349170039445531	no	132	0.00213385611348859	43	NA					Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate	biological_process	molecular_function	cellular_component
YNL246W	YNL246W	VPS75	hom	Verified	2.69551806378735	0.00351396335351265	no	133	0.00656232996492129	107	NA	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress	double-strand break repair via nonhomologous end joining|nucleosome assembly|positive regulation of histone acetylation	histone binding|acetyltransferase activator activity	chromatin|nucleus
YDL069C	YDL069C	CBS1	hom	Verified	2.6935116219258	0.00353518402150306	no	134	0.00447754058348377	56	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader	mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation	translation regulator activity	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial ribosome
YMR247C	YMR247C	RKR1	hom	Verified	2.69293271846119	0.0035413280120729	no	135	0.00180206602374761	58	NA	FT	CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING	NUCLEUS		RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice	chromatin modification|chromatin silencing at telomere|ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity|ribosome binding	ribosome|nucleus
YGL208W	YGL208W	SIP2	hom	Verified	2.68967950605566	0.00357603351098646	no	136	0.00257707576008622	42	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	PLASMA MEMBRANE		One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane	cellular response to glucose starvation|signal transduction|protein phosphorylation|replicative cell aging|invasive growth in response to glucose limitation|regulation of protein complex assembly	AMP-activated protein kinase activity	AMP-activated protein kinase complex|plasma membrane|cytoplasm
YBR081C	YBR081C	SPT7	hom	Verified	2.68353203568266	0.003642449772468	no	137	0.0109841112130086	95	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION	HISTONE ACETYLTRANSFERASE	Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex	conjugation with cellular fusion|histone acetylation|protein complex assembly|chromatin modification	structural molecule activity	SLIK (SAGA-like) complex|mitochondrion|SAGA complex
YDR379W	YDR379W	RGA2	hom	Verified	2.67857845294595	0.00369677048285403	no	138	0.00174527723386226	33	NA	FT	SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p	budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|actin filament organization|pseudohyphal growth|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth	Rho GTPase activator activity	cellular bud neck split septin rings
YOL081W	YOL081W	IRA2	hom	Verified	2.66357373440112	0.00386577327986006	no	139	0.00740876779984578	115	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication	negative regulation of cAMP biosynthetic process|negative regulation of Ras protein signal transduction|positive regulation of Ras GTPase activity|response to stress	Ras GTPase activator activity	mitochondrion|integral to membrane|cytoplasm
YOR091W	YOR091W	TMA46	hom	Verified	2.63664151616821	0.00418656331927629	no	140	0.0050051146982427	87	NA	FT	TRANSLATION			Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p	cytoplasmic translation	molecular_function	polysomal ribosome|ribosome|cytoplasm
YDR403W	YDR403W	DIT1	hom	Verified	2.62131392070805	0.00437957824450796	no	141	0.00265455132683249	65	NA	FT	CELL WALL ORG/BIOGENESIS			Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure	ascospore wall assembly	catalytic activity	cellular_component
YBL083C_d	YBL083C	YBL083C	hom	Dubious	2.621148524793	0.00438170368059084	no	142	0.00458484549239926	111	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3	Unknown	Unknown	Unknown
YIL065C	YIL065C	FIS1	hom	Verified	2.62041027733438	0.00439120184294726	no	143	0.00369019436970592	79	NA	FT	MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	MITOCHONDRION		Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation	peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization	molecular_function	mitochondrial outer membrane|mitochondrion|peroxisome
YGR178C	YGR178C	PBP1	hom	Verified	2.61829604269206	0.00441850507880385	no	144	0.00680152112403456	116	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION	NUCLEUS|MITOCHONDRION		Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	positive regulation of translation|mRNA polyadenylation|stress granule assembly	molecular_function	mitochondrion|nucleus|polysome|cytoplasmic stress granule|cytoplasm
YGL261C_p	YGL261C	PAU11	hom	Uncharacterized	2.61595932619258	0.0044488577994794	no	145	0.00391711389619982	48	NA					Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2	biological_process	molecular_function	cellular_component
YML071C	YML071C	COG8	hom	Verified	2.60536424818229	0.00458883170523287	no	146	0.0870161980532374	459	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YGR271C-A	YGR271C-A	EFG1	hom	Verified	2.60234583667595	0.00462942159847608	no	147	0.00960611760233046	108	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus	G1 phase of mitotic cell cycle|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus
YDL185W	YDL185W	VMA1	hom	Verified	2.5996221795336	0.00466632246882271	no	148	0.027505542212994	200	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM		Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease	intron homing|cellular protein metabolic process|vacuolar acidification	endodeoxyribonuclease activity|proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane
YDL133W	YDL133W	SRF1	hom	Verified	2.5992811876093	0.00467096075881271	no	149	0.0134636392515584	113	NA					Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients	positive regulation of catalytic activity	molecular_function	integral to membrane
YCR064C_d	YCR064C	YCR064C	hom	Dubious	2.59364752770086	0.00474818937480411	no	150	0.0126370371315122	150	NA	FF				Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31	Unknown	Unknown	Unknown
YKL057C	YKL057C	NUP120	hom	Verified	2.58353334600328	0.00488970064854191	no	151	0.0135893765147029	146	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160	double-strand break repair|protein export from nucleus|ribosomal large subunit export from nucleus|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore outer ring
YJR102C	YJR102C	VPS25	hom	Verified	2.58231165486737	0.0049070457278486	no	152	0.0239430913750807	259	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome	negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	structural molecule activity	ESCRT II complex
YLR373C	YLR373C	VID22	hom	Verified	2.57762238638327	0.00497413228015043	no	153	0.00817944148710222	119	NA	FT	PROTEIN LOCALIZATION	NUCLEUS|PLASMA MEMBRANE		Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles	vacuolar protein catabolic process	molecular_function	integral to plasma membrane
YDL037C	YDL037C	BSC1	hom	Verified	2.57602083720139	0.0049972311556928	no	154	0.00631096439280381	60	NA					Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression	biological_process	molecular_function	cellular_component
YGR206W	YGR206W	MVB12	hom	Verified	2.57505522784355	0.00501120410080737	no	155	0.00422500137978502	69	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT			ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin	negative regulation of protein complex assembly|protein targeting to vacuole|endosome transport via multivesicular body sorting pathway	ubiquitin binding	cytosol|endosome|ESCRT I complex
YNL266W_d	YNL266W	YNL266W	hom	Dubious	2.5712070704388	0.00506723552592913	no	156	0.00245475723995535	50	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C	Unknown	Unknown	Unknown
YGR026W_p	YGR026W	YGR026W	hom	Uncharacterized	2.56223988347544	0.00519997293204238	no	157	0.0053337095375664	51	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	integral to membrane
YGR183C	YGR183C	QCR9	hom	Verified	2.56204878759149	0.00520283500161375	no	158	0.00508563142802501	73	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex	iron-sulfur cluster assembly|mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YBR281C	YBR281C	DUG2	hom	Verified	2.5434874291361	0.0054876003052205	no	159	0.00507290209151471	96	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS	NUCLEUS		Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	peptidase activity|gamma-glutamyltransferase activity|omega peptidase activity	nucleus|cytoplasm
YDR484W	YDR484W	VPS52	hom	Verified	2.53995669883891	0.0055433096993929	no	160	0.0268079304452063	133	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS|CYTOSKELETON		Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin	actin filament-based process|Golgi to vacuole transport|retrograde transport, endosome to Golgi	protein binding	Golgi apparatus|GARP complex
YNL147W	YNL147W	LSM7	hom	Verified	2.53899170008818	0.00555862303228996	no	161	0.00728667634511471	128	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasm
YNR036C	YNR036C	MRPS12	hom	Verified	2.52469308532019	0.00578996859744293	no	162	0.0081041376296082	123	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins	mitochondrial translation	structural constituent of ribosome	mitochondrion|ribosome|mitochondrial small ribosomal subunit
YDR414C	YDR414C	ERD1	hom	Verified	2.52302544003618	0.00581749917232539	no	163	0.00815931514945954	117	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)	protein retention in ER lumen|protein glycosylation	molecular_function	integral to membrane|membrane
YDR304C	YDR304C	CPR5	hom	Verified	2.51910719703776	0.00588264158381241	no	164	0.0042623276749312	70	NA	FT		ENDOPLASMIC RETICULUM		Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER	biological_process	peptidyl-prolyl cis-trans isomerase activity	endoplasmic reticulum|cytoplasm
YGL212W	YGL212W	VAM7	hom	Verified	2.51492727253034	0.00595284703327707	no	165	0.00832079569782832	130	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress	piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle fusion	SNAP receptor activity|phosphatidylinositol-3-phosphate binding	SNARE complex|fungal-type vacuole membrane
YBL071W-A	YBL071W-A	KTI11	hom	Verified	2.49744935170604	0.00625451665495315	no	166	0.0149385727979917	113	NA	FT	RNA PROCESSING	NUCLEUS		Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs	peptidyl-diphthamide biosynthetic process from peptidyl-histidine|tRNA wobble uridine modification	electron carrier activity|iron ion binding|zinc ion binding	nucleus|cytoplasm
YDR318W	YDR318W	MCM21	hom	Verified	2.4945475691039	0.00630589103790532	no	167	0.0127448733527427	124	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	COMA complex|condensed nuclear chromosome kinetochore
YDR485C	YDR485C	VPS72	hom	Verified	2.48909066359646	0.00640351508301384	no	168	0.0216320377335831	212	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting	chromatin remodeling|histone exchange	histone binding	Swr1 complex|nucleus|cytoplasm
YDR219C	YDR219C	MFB1	hom	Verified	2.4855632612859	0.00646732977440685	no	169	0.00311879775499965	42	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|mitochondrion organization	molecular_function	extrinsic to mitochondrial outer membrane|SCF ubiquitin ligase complex
YOR065W	YOR065W	CYT1	hom	Verified	2.48221261966761	0.0065284670263806	no	170	0.00399277381372305	49	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex	oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c	electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity	mitochondrion|mitochondrial respiratory chain|integral to membrane|mitochondrial inner membrane|mitochondrial respiratory chain complex III
YDL067C	YDL067C	COX9	hom	Verified	2.48102473458219	0.00655026410399789	no	171	0.00673566037550402	101	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YIL098C	YIL098C	FMC1	hom	Verified	2.47989398315978	0.00657107257351379	no	172	0.00848625234250128	108	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p	mitochondrial proton-transporting ATP synthase complex assembly	molecular_function	mitochondrion|mitochondrial matrix
YGL215W	YGL215W	CLG1	hom	Verified	2.47959672026313	0.00657655259982487	no	173	0.00960192859332348	82	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS			Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2	positive regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YNL170W_d	YNL170W	YNL170W	hom	Dubious	2.47679624185778	0.00662837796933016	no	174	0.0114026842330829	144	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR017W	YHR017W	YSC83	hom	Verified	2.45685656336948	0.00700793177835547	no	175	0.0144986735044233	153	NA	FT		MITOCHONDRION		Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YGR150C	YGR150C	CCM1	hom	Verified	2.44965277634447	0.00714970166447501	no	176	0.0130071252854273	131	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport	rRNA metabolic process|mitochondrial RNA processing|mitochondrial genome maintenance	rRNA binding	mitochondrion
YGL035C	YGL035C	MIG1	hom	Verified	2.43630371687163	0.00741911000072315	no	177	0.0109840297907168	122	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|NUCLEUS		Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion	negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus|nuclear envelope lumen|cytoplasm
YDR520C_p	YDR520C	URC2	hom	Uncharacterized	2.43372801663095	0.007472109814928	no	178	0.014705183890737	65	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism	uracil catabolic process	sequence-specific DNA binding	nucleus|cytoplasm
YOR030W	YOR030W	DFG16	hom	Verified	2.42758776709802	0.00759980434709625	no	179	0.0171828326856754	192	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p	pseudohyphal growth|protein processing	molecular_function	integral to membrane
YOR125C	YOR125C	CAT5	hom	Verified	2.42749698635674	0.00760170657852969	no	180	0.00522205414491079	88	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation	ubiquinone biosynthetic process	monooxygenase activity	mitochondrion|mitochondrial inner membrane
YGR033C	YGR033C	TIM21	hom	Verified	2.42691087460963	0.00761399813477909	no	181	0.00531626100655617	68	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity	protein import into mitochondrial matrix	molecular_function	mitochondrion|mitochondrial inner membrane presequence translocase complex
YMR154C	YMR154C	RIM13	hom	Verified	2.42540055583575	0.00764575224491346	no	182	0.00885631605545601	203	NA	FF|FT	ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS			Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB	protein processing	cysteine-type endopeptidase activity	cellular_component
YDL151C_d	YDL151C	BUD30	hom	Dubious	2.42224595033912	0.00771245342422046	no	183	0.0103871278988906	111	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YDR438W	YDR438W	THI74	hom	Verified	2.41208874538395	0.00793071011932573	no	184	0.00931962860963954	83	NA	FT		MITOCHONDRION		Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane
YGR056W	YGR056W	RSC1	hom	Verified	2.4118231632349	0.00793648905729596	no	185	0.0343096937991427	228	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook	double-strand break repair|ATP-dependent chromatin remodeling|regulation of sporulation resulting in formation of a cellular spore|double-strand break repair via nonhomologous end joining|nucleosome disassembly|transcription elongation from RNA polymerase II promoter	DNA-dependent ATPase activity	RSC complex
YGL089C	YGL089C	MF(ALPHA)2	hom	Verified	2.41082801603423	0.00795817592239779	no	186	0.00597707195320966	80	NA	FT	SIGNALING			Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YGL020C	YGL020C	GET1	hom	Verified	2.40667954712447	0.00804914431642958	no	187	0.0200750610623394	181	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance	retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane	protein anchor	mitochondrion|integral to membrane|endoplasmic reticulum|GET complex
YGR154C	YGR154C	GTO1	hom	Verified	2.40337366110979	0.00812228954969947	no	188	0.00670166327485525	74	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization	glutathione metabolic process	glutathione transferase activity	peroxisome
YEL059C-A	YEL059C-A	SOM1	hom	Verified	2.39813853644525	0.00823931575894205	no	189	0.00553044747506494	78	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs	proteolysis|mitochondrial respiratory chain complex assembly	endopeptidase activity	mitochondrial inner membrane peptidase complex|mitochondrial inner membrane
YGL196W	YGL196W	DSD1	hom	Verified	2.39626161954366	0.00828163169779991	no	190	0.00874374518782608	85	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate	D-serine metabolic process	D-serine ammonia-lyase activity	cellular_component
YMR275C	YMR275C	BUL1	hom	Verified	2.39058776643272	0.00841071405851597	no	191	0.0116421056555075	117	NA	FT	MITOCHONDRION ORGANIZATION	PLASMA MEMBRANE	UBIQUITIN LIGASE COMPLEX	Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication	mitochondrion inheritance|protein monoubiquitination|protein polyubiquitination	ubiquitin-ubiquitin ligase activity	ubiquitin ligase complex|plasma membrane
YOR309C_d	YOR309C	YOR309C	hom	Dubious	2.37978106949162	0.00866146325893927	no	192	0.015569718337634	139	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58	Unknown	Unknown	Unknown
YDR275W	YDR275W	BSC2	hom	Verified	2.36196792723419	0.00908910740273917	no	193	0.00814630532189632	66	NA					Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication	biological_process	molecular_function	lipid particle
YGR285C	YGR285C	ZUO1	hom	Verified	2.36191313883828	0.00909045074179153	no	194	0.010200442329502	144	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS|MITOCHONDRION	RIBOSOME	Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p	protein folding|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity	unfolded protein binding	mitochondrion|ribosome|nucleolus|polysome|cytoplasm
YMR205C	YMR205C	PFK2	hom	Verified	2.36145304640744	0.00910173846166675	no	195	0.0217057178953605	193	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes	proton transport|glycolysis	mRNA binding|6-phosphofructokinase activity	mitochondrion|6-phosphofructokinase complex|cytoplasm
YDR333C	YDR333C	RQC1	hom	Verified	2.35932227730978	0.00915417405625252	no	196	0.00616490962562577	62	NA					Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC	biological_process	molecular_function	cytoplasm
YBL009W	YBL009W	ALK2	hom	Verified	2.35732936508184	0.00920345631540253	no	197	0.00628049798076156	63	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION			Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins	meiosis|mitosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YDR490C	YDR490C	PKH1	hom	Verified	2.3530199236753	0.00931081814910733	no	198	0.00598583961498745	67	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION			Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p	regulation of nuclear-transcribed mRNA poly(A) tail shortening|endocytosis|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly	protein kinase activity	cytosol|cell cortex|eisosome
YDR336W_p	YDR336W	YDR336W	hom	Uncharacterized	2.35150408293573	0.00934884221006066	no	199	0.0118969497744368	99	NA					Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene	biological_process	molecular_function	cellular_component
YOL012C	YOL012C	HTZ1	hom	Verified	2.35093390633287	0.00936317990803047	no	200	0.0154631874407739	191	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin	nuclear-transcribed mRNA catabolic process, non-stop decay|regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	chromatin binding	nuclear chromatin|chromatin assembly complex
YDL077C	YDL077C	VAM6	hom	Verified	2.34095177449773	0.00961732573290875	no	201	0.03122992955148	230	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION			Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle-mediated transport|vacuole organization|vacuole fusion, non-autophagic	Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding	fungal-type vacuole membrane|HOPS complex|fungal-type vacuole
YDR069C	YDR069C	DOA4	hom	Verified	2.33925622007127	0.00966108851383102	no	202	0.0151438114722223	155	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEOLYSIS	MITOCHONDRION		Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole	protein deubiquitination|endocytosis|regulation of DNA replication|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|free ubiquitin chain depolymerization|ubiquitin homeostasis|ubiquitin-dependent protein catabolic process	endopeptidase activity|ubiquitin-specific protease activity|ubiquitin thiolesterase activity	endosome|proteasome complex|mitochondrion
YDR321W	YDR321W	ASP1	hom	Verified	2.3379040548517	0.00969611294076782	no	203	0.00955604308505524	77	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively	asparagine catabolic process	asparaginase activity	intracellular
YBL086C_p	YBL086C	YBL086C	hom	Uncharacterized	2.33780482349929	0.00969868764275991	no	204	0.00557784195607714	39	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YOR036W	YOR036W	PEP12	hom	Verified	2.33398952496196	0.00979813521166762	no	205	0.0256854626779503	252	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin	Golgi to vacuole transport|vacuole inheritance	SNAP receptor activity	endosome|Golgi apparatus
YER046W-A_d	YER046W-A	YER046W-A	hom	Dubious	2.33353290737806	0.00981009663850542	no	206	0.00711433523301842	66	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL130W	YDL130W	RPP1B	hom	Verified	2.31451598021007	0.0103197178563903	no	207	0.0160404666269169	117	NA	FT	TRANSLATION		RIBOSOME	Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component	cytoplasmic translation|translational elongation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGL197W	YGL197W	MDS3	hom	Verified	2.30784490676038	0.010503882113134	no	208	0.018986939976403	119	NA	FT	CELL CYCLE|SIGNALING	MITOCHONDRION		Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain	TOR signaling cascade|negative regulation of sporulation resulting in formation of a cellular spore	molecular_function	mitochondrion|cytoplasm
YNL323W	YNL323W	LEM3	hom	Verified	2.307560944813	0.0105117844247443	no	209	0.0512290292362617	312	NA	FF|FT	MEMBRANE ORGANIZATION|SIGNALING	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane	phospholipid translocation|cell surface receptor signaling pathway	phospholipid-translocating ATPase activity	integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YDR447C	YDR447C	RPS17B	hom	Verified	2.29693621717543	0.0108112042805472	no	210	0.0128388714364398	95	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit
YGR214W	YGR214W	RPS0A	hom	Verified	2.2930988953898	0.0109211559877113	no	211	0.00977641342668838	81	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YEL018W	YEL018W	EAF5	hom	Verified	2.29224506875758	0.0109457528123237	no	212	0.0150168455295586	100	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex	DNA repair	molecular_function	nucleus|NuA4 histone acetyltransferase complex
YDL075W	YDL075W	RPL31A	hom	Verified	2.28896010005704	0.0110408353830203	no	213	0.0226207462654586	143	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication	cytoplasmic translation|regulation of translational fidelity	structural constituent of ribosome	cytosolic large ribosomal subunit
YML073C	YML073C	RPL6A	hom	Verified	2.28814242644148	0.0110646141109509	no	214	0.0135605548159078	106	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YGR148C	YGR148C	RPL24B	hom	Verified	2.28793170607702	0.0110707492738727	no	215	0.0145253546164723	116	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YDR004W	YDR004W	RAD57	hom	Verified	2.28505183196721	0.0111548943565127	no	216	0.0164717844437372	167	NA	FF|FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p	DNA recombinase assembly|telomere maintenance via recombination|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|protein heterodimerization activity	nucleus|Rhp55-Rhp57 complex
YDL088C	YDL088C	ASM4	hom	Verified	2.27568838013591	0.011432333660968	no	217	0.0109699079620192	96	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication	nuclear pore organization|mRNA export from nucleus in response to heat stress|mitotic cell cycle spindle assembly checkpoint	nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding	nuclear pore central transport channel|integral to membrane|nuclear pore
YNL098C	YNL098C	RAS2	hom	Verified	2.27036321295713	0.0115927772866794	no	218	0.0260931020542039	145	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS	PLASMA MEMBRANE		GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes	pseudohyphal growth|ascospore formation|activation of adenylate cyclase activity|regulation of protein localization|replicative cell aging|positive regulation of transcription by galactose|Ras protein signal transduction	GTP binding|GTPase activity	plasma membrane
YIR021W-A_p	YIR021W-A	YIR021W-A	hom	Uncharacterized	2.25518559479893	0.012060840867518	no	219	0.0127002724431188	97	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YFL016C	YFL016C	MDJ1	hom	Verified	2.25111138721064	0.0121892416871933	no	220	0.0292241202525661	160	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones	protein refolding|response to heat|misfolded or incompletely synthesized protein catabolic process|mitochondrial genome maintenance|'de novo' protein folding	unfolded protein binding|ATPase activator activity	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YBL078C	YBL078C	ATG8	hom	Verified	2.24588220630703	0.0123557769532208	no	221	0.0209216739054009	165	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM		Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis	piecemeal microautophagy of nucleus|mitochondrion degradation|cellular membrane fusion|ER to Golgi vesicle-mediated transport|CVT pathway|autophagic vacuole assembly	molecular_function	cytosol|fungal-type vacuole membrane|pre-autophagosomal structure|extrinsic to membrane|autophagic vacuole
YKR085C	YKR085C	MRPL20	hom	Verified	2.23558650119513	0.0126894348181975	no	222	0.01900660283764	153	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YEL022W	YEL022W	GEA2	hom	Verified	2.23287182957129	0.0127786988820994	no	223	0.030173662513079	189	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication	retrograde vesicle-mediated transport, Golgi to ER|secretory granule organization|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization	ARF guanyl-nucleotide exchange factor activity	integral to membrane|Golgi cis cisterna|extrinsic to membrane
YOR304C-A_p	YOR304C-A	YOR304C-A	hom	Uncharacterized	2.22875090740928	0.0129152415078782	no	224	0.0184109579326609	139	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck	biological_process	molecular_function	cellular bud|mating projection tip|cellular bud neck|cytoplasm
YDR282C_p	YDR282C	YDR282C	hom	Uncharacterized	2.22002560513957	0.0132085147739777	no	225	0.00612015529456408	67	NA					Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation	biological_process	molecular_function	cellular_component
YNL324W_d	YNL324W	YNL324W	hom	Dubious	2.21974834635181	0.013217927510381	no	226	0.0244222612894977	145	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBL082C	YBL082C	ALG3	hom	Verified	2.21247725431325	0.0134668530667819	no	227	0.00822561081585424	87	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins	oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation	alpha-1,3-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YDL089W	YDL089W	NUR1	hom	Verified	2.21165778633899	0.0134951596821607	no	228	0.01766457997232	131	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate	maintenance of rDNA	molecular_function	nuclear periphery
YDL238C	YDL238C	GUD1	hom	Verified	2.2025921300821	0.013811754553641	no	229	0.014674154423558	126	NA					Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures	guanine metabolic process	guanine deaminase activity|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	cytoplasm
YJR073C	YJR073C	OPI3	hom	Verified	2.20079455985104	0.0138752854505156	no	230	0.0364204491152962	282	NA	FF|FT	LIPID METABOLISM	MITOCHONDRION		Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis	phosphatidylcholine biosynthetic process	phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|phosphatidyl-N-methylethanolamine N-methyltransferase activity	mitochondrion|integral to membrane
YGR160W_d	YGR160W	YGR160W	hom	Dubious	2.19924016758261	0.0139304247982972	no	231	0.0121834626229044	87	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR049W	YDR049W	VMS1	hom	Verified	2.19885334930893	0.0139441758206392	no	232	0.00966842174979275	134	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans	ER-associated protein catabolic process|mitochondria-associated protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process	molecular_function	cytosol|mitochondrion|endoplasmic reticulum membrane|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytoplasm
YDR017C	YDR017C	KCS1	hom	Verified	2.19221142753813	0.0141821218495542	no	233	0.0174912177197288	149	NA					Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance	inositol phosphate biosynthetic process	inositol heptakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol heptakisphosphate 5-kinase activity	cytoplasm
YPL246C	YPL246C	RBD2	hom	Verified	2.18846053429301	0.0143180365012458	no	234	0.00995883095734285	89	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p	biological_process	molecular_function	COPI-coated vesicle|integral to membrane|Golgi apparatus
YNL133C	YNL133C	FYV6	hom	Verified	2.18075917037583	0.0146006169856465	no	235	0.0318901224474052	189	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining	double-strand break repair via nonhomologous end joining	molecular_function	nucleus
YGR173W	YGR173W	RBG2	hom	Verified	2.17504649934674	0.0148133160135505	no	236	0.0140542994576073	70	NA	FT	TRANSLATION			Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein	cytoplasmic translation	GTP binding	cytoplasm
YBL093C	YBL093C	ROX3	hom	Verified	2.1682021492775	0.01507165468403	no	237	0.0233784476409526	172	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme	negative regulation of transcription from RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription factor recruiting transcription factor activity	core mediator complex|nucleus
YNL069C	YNL069C	RPL16B	hom	Verified	2.16542677721064	0.0151775086313997	no	238	0.0257821255717564	151	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YBR200W	YBR200W	BEM1	hom	Verified	2.1631715367155	0.0152639943003309	no	239	0.0100376708998336	75	NA	FT		SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p	establishment of cell polarity|cell morphogenesis involved in conjugation with cellular fusion	protein complex scaffold|phosphatidylinositol-3-phosphate binding	incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip
YGR212W	YGR212W	SLI1	hom	Verified	2.15499441136017	0.0155811357754799	no	240	0.0173709128798455	106	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin	response to drug	N-acetyltransferase activity	nuclear envelope|plasma membrane
YGL033W	YGL033W	HOP2	hom	Verified	2.15485822268602	0.015586465230514	no	241	0.0371452086563122	231	NA	FF|FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair	synapsis|reciprocal meiotic recombination	protein binding|double-stranded DNA binding	condensed nuclear chromosome
YDR019C	YDR019C	GCV1	hom	Verified	2.14154534193597	0.0161150430469242	no	242	0.0205068850961663	124	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm	glycine catabolic process|glycine metabolic process|one-carbon metabolic process	glycine dehydrogenase (decarboxylating) activity	mitochondrion|glycine cleavage complex
YER084W_p	YER084W	YER084W	hom	Uncharacterized	2.13911362748442	0.0162132335028746	no	243	0.0215418472718687	177	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YOL158C	YOL158C	ENB1	hom	Verified	2.13900334887186	0.0162176985772234	no	244	0.0149135814909016	84	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment	ferric-enterobactin transport	ferric-enterobactin transmembrane transporter activity	integral to membrane|cellular bud membrane|plasma membrane
YNR008W	YNR008W	LRO1	hom	Verified	2.13819489731918	0.0162504641781954	no	245	0.0161177107285154	158	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase	lipid storage|triglyceride biosynthetic process	phospholipid:diacylglycerol acyltransferase activity	lipid particle|perinuclear endoplasmic reticulum
YOR360C	YOR360C	PDE2	hom	Verified	2.13533507050826	0.0163668250970252	no	246	0.0221000405698176	120	NA	FT	SIGNALING	NUCLEUS		High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon	cAMP-mediated signaling	3',5'-cyclic-AMP phosphodiesterase activity	nucleus|cytoplasm
YOR158W	YOR158W	PET123	hom	Verified	2.13319304684606	0.0164544466414032	no	247	0.0209217020367612	189	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YDR377W	YDR377W	ATP17	hom	Verified	2.12438342922634	0.0168190472462559	no	248	0.0201483148168082	152	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YDR452W	YDR452W	PPN1	hom	Verified	2.11676143343038	0.017140050013197	no	249	0.0311616407727725	64	NA	FT		NUCLEUS		Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress	polyphosphate catabolic process|polyphosphate metabolic process	endopolyphosphatase activity|exopolyphosphatase activity	fungal-type vacuole membrane|nucleus
YIL053W	YIL053W	RHR2	hom	Verified	2.10961371833688	0.0174458208725784	no	250	0.0301003512751678	224	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication	glycerol biosynthetic process|response to osmotic stress	glycerol-1-phosphatase activity	nucleus|cytoplasm
YJR105W	YJR105W	ADO1	hom	Verified	2.108126398287	0.0175100287868497	no	251	0.0580404899081489	316	NA	FF|FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle	purine nucleobase metabolic process	adenosine kinase activity	nucleus|cytoplasm
YDR075W	YDR075W	PPH3	hom	Verified	2.10753644155239	0.0175355531668117	no	252	0.0101398422654241	131	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes	Unknown|signal transduction involved in meiotic recombination checkpoint|double-strand break repair via homologous recombination|protein dephosphorylation|positive regulation of nitrogen compound metabolic process	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus|cytoplasm
YKL068W-A_p	YKL068W-A	YKL068W-A	hom	Uncharacterized	2.10109319870437	0.017816392912296	no	253	0.0380279755562507	217	NA					Putative protein of unknown function; identified by homology to <i>Ashbya gossypii</i>	biological_process	molecular_function	cellular_component
YOR023C	YOR023C	AHC1	hom	Verified	2.09396146520445	0.0181317065531418	no	254	0.0133513773954084	120	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex	histone acetylation	histone acetyltransferase activity	Ada2/Gcn5/Ada3 transcription activator complex
YPR108W-A_p	YPR108W-A	YPR108W-A	hom	Uncharacterized	2.0937269337193	0.0181421561098021	no	255	0.0224481857615986	127	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YGL259W_p	YGL259W	YPS5	hom	Uncharacterized	2.09285676474034	0.0181809713753787	no	256	0.0136978957629125	87	NA	FT	PROTEOLYSIS			Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p	biological_process	aspartic-type endopeptidase activity	cellular_component
YNL013C_d	YNL013C	YNL013C	hom	Dubious	2.08677417221165	0.0184542764329879	no	257	0.00960894232444293	84	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W	Unknown	Unknown	Unknown
YDR525W_d	YDR525W	API2	hom	Dubious	2.0708044473099	0.0191885372322916	no	258	0.0373239008881457	186	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology	Unknown	Unknown	Unknown
YCR045C	YCR045C	RRT12	hom	Verified	2.07071803495902	0.0191925769144877	no	259	0.0212437294655253	185	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS		Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores	ascospore wall assembly	serine-type peptidase activity	nuclear envelope|ascospore wall
YGL083W	YGL083W	SCY1	hom	Verified	2.07007596805929	0.019222615482451	no	260	0.0116129203805604	98	NA	FT	PROTEIN PHOSPHORYLATION			Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase	biological_process	molecular_function	clathrin-coated vesicle
YDR363W	YDR363W	ESC2	hom	Verified	2.06526583526719	0.0194489271514864	no	261	0.0257312352274832	151	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS		Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member	intra-S DNA damage checkpoint|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette|mitotic sister chromatid cohesion	molecular_function	nucleus
YOL013C	YOL013C	HRD1	hom	Verified	2.03775345948014	0.0207872974437479	no	262	0.0103558155480947	136	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon	fungal-type cell wall organization|ER-associated protein catabolic process	ubiquitin-protein ligase activity	Hrd1p ubiquitin ligase ERAD-M complex|integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YBL024W	YBL024W	NCL1	hom	Verified	2.03716903166884	0.0208165530322774	no	263	0.0401717251119869	160	NA	FT	RNA PROCESSING	NUCLEUS		S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120	tRNA methylation	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YOR068C	YOR068C	VAM10	hom	Verified	2.0361491725587	0.0208676891587572	no	264	0.0246655190745345	192	NA	FT	MEMBRANE ORGANIZATION			Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering	vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane
YDR079C-A	YDR079C-A	TFB5	hom	Verified	2.0304009487457	0.0211579001544146	no	265	0.0202595058393336	188	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS	RNA POL II, HOLOENZYME	Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleus
YGL167C	YGL167C	PMR1	hom	Verified	2.02733212769347	0.0213142289916126	no	266	0.0466696105889462	221	NA	FT	VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease	manganese ion transport|calcium ion transport|exocytosis	manganese-transporting ATPase activity|calcium-transporting ATPase activity|calcium ion binding	integral to membrane|Golgi membrane
YDL090C	YDL090C	RAM1	hom	Verified	2.02584399343636	0.0213903870280255	no	267	0.0626877620916593	309	NA	FF|FT	PROTEIN PRENYLATION			Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit	protein farnesylation	protein farnesyltransferase activity	protein farnesyltransferase complex
YMR119W-A_d	YMR119W-A	YMR119W-A	hom	Dubious	2.02272901870447	0.0215505466746699	no	268	0.0211420440458304	122	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR348C	YDR348C	PAL1	hom	Verified	2.02163637632988	0.0216069655870323	no	269	0.0203896905631373	151	NA	FT		SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cell cortex|cellular bud neck|mating projection tip
YFL007W	YFL007W	BLM10	hom	Verified	2.02121528574354	0.0216287420188214	no	270	0.0207757991613957	161	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200	proteasome assembly|regulation of proteasomal protein catabolic process	proteasome binding|peptidase activator activity	proteasome core complex|proteasome complex|integral to membrane|nucleus
YGR164W_d	YGR164W	YGR164W	hom	Dubious	2.02030264987342	0.0216760020600411	no	271	0.0211176909314105	201	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR060C	YMR060C	SAM37	hom	Verified	2.01748842964248	0.0218222836377571	no	272	0.0425651139468233	219	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability	mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to membrane
YCR002C	YCR002C	CDC10	hom	Verified	2.01388300566389	0.0220109090911787	no	273	0.0342965246270793	201	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress	sporulation|maintenance of cell polarity|exit from mitosis|cell cycle cytokinesis|septin ring assembly	protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding	spindle microtubule|ascospore-type prospore|septin complex|prospore membrane|mating projection base|meiotic spindle|septin filament array|cellular bud neck septin ring|mating projection tip
YCR087W_d	YCR087W	YCR087W	hom	Dubious	2.00622158103481	0.0224163061665759	no	274	0.0280625393279657	174	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene	Unknown	Unknown	Unknown
YNR013C	YNR013C	PHO91	hom	Verified	2.00424147631913	0.0225220997878843	no	275	0.0275356992988439	144	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth	phosphate ion transport|polyphosphate metabolic process	phosphate ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|membrane
YDL107W	YDL107W	MSS2	hom	Verified	2.00078354245607	0.0227078608678356	no	276	0.021529710479897	127	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p	protein insertion into mitochondrial membrane from inner side	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrial matrix
YGL221C	YGL221C	NIF3	hom	Verified	2.00023535100102	0.0227374281103772	no	277	0.0180605608487579	129	NA	FT		MITOCHONDRION		Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YNL225C	YNL225C	CNM67	hom	Verified	1.99946984617676	0.0227787706443868	no	278	0.0398042668458228	239	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication	microtubule nucleation|mitotic spindle organization	structural constituent of cytoskeleton	outer plaque of spindle pole body|spindle pole body
YGR118W	YGR118W	RPS23A	hom	Verified	1.99863076616666	0.0228241594978719	no	279	0.0278472860167781	152	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR457W	YDR457W	TOM1	hom	Verified	1.99833883798321	0.0228399688006515	no	280	0.0155573940562722	146	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|PROTEOLYSIS|RNA LOCALIZATION	NUCLEUS		E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mitosis|nucleocytoplasmic transport|nucleus organization|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell size|protein ubiquitination	ubiquitin-protein ligase activity	integral to membrane|nucleolus|nucleus
YIL005W	YIL005W	EPS1	hom	Verified	1.9965401483703	0.0229375801031808	no	281	0.022168683572611	179	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family	protein retention in ER lumen|ER-associated protein catabolic process	unfolded protein binding|protein disulfide isomerase activity|chaperone binding	endoplasmic reticulum membrane
YDR184C	YDR184C	ATC1	hom	Verified	1.99652333762976	0.0229384940434745	no	282	0.0346773350508052	213	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS		Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress	bipolar cellular bud site selection|response to stress	molecular_function	nucleus
YGR257C	YGR257C	MTM1	hom	Verified	1.98904455422488	0.0233481427073274	no	283	0.0440586579137921	263	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor	manganese ion transport|transport	transporter activity|metallochaperone activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YGL228W	YGL228W	SHE10	hom	Verified	1.98143909647332	0.0237710264903105	no	284	0.0221772088607103	152	NA	FT		MITOCHONDRION		Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest	biological_process	molecular_function	cellular_component
YDR192C	YDR192C	NUP42	hom	Verified	1.97570402122677	0.0240941546115147	no	285	0.0205829968036176	117	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p	poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YOR006C	YOR006C	TSR3	hom	Verified	1.9653567395244	0.0246864813849328	no	286	0.0401061047592563	208	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress	maturation of SSU-rRNA	molecular_function	nucleus|cytoplasm
YDR072C	YDR072C	IPT1	hom	Verified	1.96428886872747	0.0247483009136032	no	287	0.0244723106368311	196	NA	FT	LIPID METABOLISM			Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin	mannosyl diphosphorylinositol ceramide metabolic process|sphingolipid biosynthetic process	transferase activity, transferring phosphorus-containing groups	integral to membrane
YDR456W	YDR456W	NHX1	hom	Verified	1.95897207110726	0.0250580288293792	no	288	0.0265375742384415	245	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	GOLGI APPARATUS		Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion	sodium ion transmembrane transport|potassium ion transmembrane transport|cellular monovalent inorganic cation homeostasis|vacuolar acidification	sodium:hydrogen antiporter activity|potassium:hydrogen antiporter activity	trans-Golgi network|late endosome|fungal-type vacuole membrane|integral to membrane|early endosome
YNL184C_p	YNL184C	YNL184C	hom	Uncharacterized	1.94955196765411	0.0256147715436622	no	289	0.0406660295490743	238	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YBR163W	YBR163W	EXO5	hom	Verified	1.9450884954283	0.02588216414904	no	290	0.0323667120266153	241	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2	mitochondrial genome maintenance	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity	mitochondrion
YGL252C	YGL252C	RTG2	hom	Verified	1.93988340150114	0.0261969308693119	no	291	0.0404095297566289	203	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|SIGNALING|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p	maintenance of DNA trinucleotide repeats|regulation of transcription from RNA polymerase II promoter|Unknown|nitrogen catabolite regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway|transcription factor import into nucleus	RNA polymerase II transcription factor binding transcription factor activity	SLIK (SAGA-like) complex|transcriptionally active chromatin|cytoplasm
YDR401W_d	YDR401W	YDR401W	hom	Dubious	1.93347167679882	0.0265890594552218	no	292	0.0304819243325791	111	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR459C	YDR459C	PFA5	hom	Verified	1.93339530312146	0.0265937597115116	no	293	0.0154025727737603	105	NA	FT		PLASMA MEMBRANE		Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain	protein palmitoylation	palmitoyltransferase activity	integral to membrane|plasma membrane
YFR001W	YFR001W	LOC1	hom	Verified	1.9333167894062	0.0265985923954443	no	294	0.0289421859923716	164	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; relocalizes from nucleus to cytoplasm upon DNA replication stress	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|intracellular mRNA localization	mRNA binding	nucleolus|preribosome, large subunit precursor
YGL226W	YGL226W	MTC3	hom	Verified	1.93217623874871	0.026668878458449	no	295	0.0201834633478773	155	NA	FT		MITOCHONDRION		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1	biological_process	molecular_function	mitochondrion
YBR078W	YBR078W	ECM33	hom	Verified	1.92880713009055	0.0268774051770656	no	296	0.073198400719887	301	NA	FF|FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p	fungal-type cell wall organization	molecular_function	mitochondrion|fungal-type cell wall|plasma membrane
YAR002W	YAR002W	NUP60	hom	Verified	1.92860176523416	0.0268901598694348	no	297	0.038639772368692	199	NA	FT	PROTEIN LOCALIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153	double-strand break repair|poly(A)+ mRNA export from nucleus|protein export from nucleus|regulation of protein desumoylation|intracellular mRNA localization|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|chromosome organization|nucleocytoplasmic transport|chromatin silencing at silent mating-type cassette	nucleocytoplasmic transporter activity|phospholipid binding|structural constituent of nuclear pore	nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YDR245W	YDR245W	MNN10	hom	Verified	1.92857598820795	0.0268917611722819	no	298	0.0327407821765601	203	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family	N-glycan processing|cell wall mannoprotein biosynthetic process|substituted mannan metabolic process|barrier septum assembly	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YGR203W	YGR203W	YCH1	hom	Verified	1.92721454817985	0.026976448828591	no	299	0.0255393630525189	182	NA	FT		NUCLEUS		Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	dephosphorylation	phosphatase activity|protein tyrosine phosphatase activity|thiosulfate sulfurtransferase activity	nucleus|cytoplasm
YGL190C	YGL190C	CDC55	hom	Verified	1.92717016640965	0.0269792133155792	no	300	0.0432229257967043	254	NA	FT	CELL CYCLE|SIGNALING	NUCLEUS|SITE OF POLARIZED GROWTH		Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion	negative regulation of exit from mitosis|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|protein dephosphorylation	protein phosphatase type 2A regulator activity	nucleus|cellular bud neck|cytoplasm|cellular bud tip
YEL053C	YEL053C	MAK10	hom	Verified	1.91939953278559	0.0274668950153899	no	301	0.0235702861992686	168	NA					Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex|cytoplasm
YDR370C	YDR370C	DXO1	hom	Verified	1.91739412522204	0.0275939400099805	no	302	0.0239699591696532	149	NA					Protein with decapping and 5&#8242;-3&#8242; exoRNase activity; similar to Rai1p	biological_process	molecular_function	cytoplasm
YGL232W	YGL232W	TAN1	hom	Verified	1.91613493764618	0.0276739611235837	no	303	0.0300518582968457	166	NA	FT	RNA PROCESSING	NUCLEUS		Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress	tRNA modification	RNA binding	nucleus|cytoplasm
YDL240W	YDL240W	LRG1	hom	Verified	1.91545370206882	0.0277173340640605	no	304	0.0281252348891084	172	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	MITOCHONDRION|SITE OF POLARIZED GROWTH		Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis	fungal-type cell wall biogenesis|small GTPase mediated signal transduction	Rho GTPase activator activity	mitochondrion|cellular bud neck|cytoplasm
YOL001W	YOL001W	PHO80	hom	Verified	1.9127105674836	0.0278925577998065	no	305	0.0474840439428016	335	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling	negative regulation of phosphate metabolic process|regulation of cyclin-dependent protein kinase activity|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|cellular metal ion homeostasis|regulation of protein localization|negative regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YOL159C	YOL159C	YOL159C	hom	Verified	1.91121756931905	0.0279883134831316	no	306	0.0166080227441287	136	NA					Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA	biological_process	molecular_function	cellular_component
YLR374C_d	YLR374C	YLR374C	hom	Dubious	1.90515766817113	0.0283797895104265	no	307	0.058222886273692	254	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W	Unknown	Unknown	Unknown
YDR395W	YDR395W	SXM1	hom	Verified	1.90146577285548	0.0286205157721218	no	308	0.0295088379966481	180	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1	mRNA export from nucleus|nucleocytoplasmic transport	protein transporter activity	integral to membrane|nucleus|cytoplasm
YDR393W	YDR393W	SHE9	hom	Verified	1.89834036757504	0.0288256297746234	no	309	0.0347191401576194	191	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex	mitochondrion organization|inner mitochondrial membrane organization	molecular_function	mitochondrial inner membrane
YGL117W_p	YGL117W	YGL117W	hom	Uncharacterized	1.8973529938354	0.0288906825709097	no	310	0.0644779625183052	370	NA	FF				Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL051W	YNL051W	COG5	hom	Verified	1.89584655994204	0.0289901685611041	no	311	0.0973219154553042	381	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YNL072W	YNL072W	RNH201	hom	Verified	1.89566078312725	0.0290024570936193	no	312	0.0785892220601241	340	NA	FT		NUCLEUS		Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome	DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus
YBR158W	YBR158W	AMN1	hom	Verified	1.88813248148022	0.0295040836215073	no	313	0.03210149215862	180	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS		Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)	mitotic cell cycle checkpoint|negative regulation of exit from mitosis	protein binding	nucleus|cellular bud|cytoplasm
YGL220W	YGL220W	FRA2	hom	Verified	1.88538328517614	0.0296890545210021	no	314	0.0322693891112706	216	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel	negative regulation of transcription from RNA polymerase II promoter in response to iron	molecular_function	cytosol|nucleus|cytoplasm
YDR313C	YDR313C	PIB1	hom	Verified	1.88534612102673	0.0296915615691043	no	315	0.0278464040237505	161	NA					RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain	protein ubiquitination	ubiquitin-protein ligase activity|phosphatidylinositol-3-phosphate binding	fungal-type vacuole membrane|late endosome
YBL071C_d	YBL071C	YBL071C	hom	Dubious	1.88439372584116	0.0297558689432869	no	316	0.0311502937181337	198	NA					Dubious open reading frame, predicted protein contains a peroxisomal targeting signal	Unknown	Unknown	Unknown
YGR003W	YGR003W	CUL3	hom	Verified	1.88256839037345	0.0298794417412234	no	317	0.0206106433789374	121	NA	FT	PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3	protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	nucleus|Cul3-RING ubiquitin ligase complex|cytoplasm
YDL094C_d	YDL094C	YDL094C	hom	Dubious	1.88191903781029	0.0299235045735041	no	318	0.0217003252325053	146	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential	Unknown	Unknown	Unknown
YER040W	YER040W	GLN3	hom	Verified	1.88000244821875	0.0300538721312277	no	319	0.0288591759238185	211	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source	nitrogen catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	cytosol|nucleus
YGL240W	YGL240W	DOC1	hom	Verified	1.87502128208356	0.0303948978791995	no	320	0.0353733271763659	229	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS	NUCLEUS|MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain	activation of mitotic anaphase-promoting complex activity|chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cyclin catabolic process	enzyme regulator activity|mitotic anaphase-promoting complex activity	mitochondrion|anaphase-promoting complex
YDR156W	YDR156W	RPA14	hom	Verified	1.87451617413366	0.0304296574436517	no	321	0.0202186386779305	123	NA	FT		NUCLEUS		RNA polymerase I subunit A14	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size	molecular_function	DNA-directed RNA polymerase I complex
YOR081C	YOR081C	TGL5	hom	Verified	1.87440968591619	0.0304369897504657	no	322	0.0206012519867125	127	NA	FT	LIPID METABOLISM			Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate	triglyceride mobilization	lysophosphatidic acid acyltransferase activity|triglyceride lipase activity	lipid particle
YLR286C	YLR286C	CTS1	hom	Verified	1.8702481234697	0.0307246848916771	no	323	0.0299589064027139	218	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p	cytokinesis, completion of separation|chitin catabolic process	endochitinase activity	nuclear envelope|extracellular region|fungal-type cell wall|endoplasmic reticulum|cellular bud neck
YDR198C	YDR198C	RKM2	hom	Verified	1.86652574410957	0.0309839228488399	no	324	0.0386017765169009	153	NA					Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp	peptidyl-lysine trimethylation|peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	cellular_component
YLR357W	YLR357W	RSC2	hom	Verified	1.85670879288448	0.0316762979258295	no	325	0.0331177588007662	188	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance	ATP-dependent chromatin remodeling|chromosome segregation|nucleosome disassembly|plasmid maintenance|sister chromatid cohesion|double-strand break repair via nonhomologous end joining|transcription elongation from RNA polymerase II promoter|double-strand break repair via homologous recombination	DNA translocase activity	RSC complex
YPL161C	YPL161C	BEM4	hom	Verified	1.85593550820856	0.0317313755103777	no	326	0.0900946381162776	381	NA	FF|FT	SIGNALING|CYTOSKELETON ORGANIZATION	NUCLEUS		Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length	establishment of cell polarity|Rho protein signal transduction|actin cytoskeleton organization	molecular_function	nucleus|cytoplasm
YGR167W	YGR167W	CLC1	hom	Verified	1.84929421603041	0.0322076702443385	no	327	0.0584536014384834	336	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE		Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W	endocytosis|vesicle-mediated transport	structural molecule activity	clathrin vesicle coat
YDR248C_p	YDR248C	YDR248C	hom	Uncharacterized	1.84398116730598	0.032592942413163	no	328	0.0231944373384856	149	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM			Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1	biological_process	molecular_function	cytoplasm
YDR316W	YDR316W	OMS1	hom	Verified	1.84096044534979	0.0328136776988616	no	329	0.0482798860607384	262	NA	FT		MITOCHONDRION		Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations	biological_process	S-adenosylmethionine-dependent methyltransferase activity	mitochondrial envelope|mitochondrion
YGL119W	YGL119W	COQ8	hom	Verified	1.84004300993499	0.0328809615618529	no	330	0.0410191244092278	191	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication	ubiquinone biosynthetic process|aerobic respiration	molecular_function	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial matrix
YNL237W	YNL237W	YTP1	hom	Verified	1.83989617901239	0.0328917405549141	no	331	0.0769235094805849	342	NA	FF|FT		MITOCHONDRION		Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins	biological_process	molecular_function	integral to membrane|membrane
YDR077W	YDR077W	SED1	hom	Verified	1.82798832406795	0.0337756519974411	no	332	0.0281538045811603	180	NA	FT	CELL WALL ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites	fungal-type cell wall organization|mitochondrial genome maintenance	structural constituent of cell wall	mitochondrion|ribosome|fungal-type cell wall
YDR505C	YDR505C	PSP1	hom	Verified	1.82288996247254	0.0341600292393393	no	333	0.026405901393096	126	NA	FT		MITOCHONDRION		Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|cytoplasm
YDR406W	YDR406W	PDR15	hom	Verified	1.82230160138668	0.0342046176805233	no	334	0.0282173955791206	148	NA	FT	NUCLEOTIDE METABOLISM			Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element	transport|response to drug	ATPase activity, coupled to transmembrane movement of substances	integral to membrane
YHR012W	YHR012W	VPS29	hom	Verified	1.81777548765454	0.0345492273016634	no	335	0.0478702105550338	303	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval	retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YGR124W	YGR124W	ASN2	hom	Verified	1.81584811887592	0.0346968368031422	no	336	0.0330115958893402	176	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication	asparagine biosynthetic process	asparagine synthase (glutamine-hydrolyzing) activity	cytoplasm
YGL254W	YGL254W	FZF1	hom	Verified	1.81473721638488	0.0347821514260689	no	337	0.0387873585510444	141	NA	FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS		Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress	positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YKL155C	YKL155C	RSM22	hom	Verified	1.81335014784641	0.0348889166488514	no	338	0.0369069873524295	193	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase	mitochondrial translation	structural constituent of ribosome|S-adenosylmethionine-dependent methyltransferase activity	mitochondrion|mitochondrial small ribosomal subunit
YDR482C	YDR482C	CWC21	hom	Verified	1.81299106240115	0.0349165999124035	no	339	0.0456467151949953	198	NA	FT	RNA PROCESSING	NUCLEUS		Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YGR125W_p	YGR125W	YGR125W	hom	Uncharacterized	1.80440440207911	0.0355839667352727	no	340	0.0364147516691174	215	NA					Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YBR246W	YBR246W	RRT2	hom	Verified	1.80402442586575	0.0356137389423197	no	341	0.0484716589370787	276	NA	FT	VESICLE-MEDIATED TRANSPORT			Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription	peptidyl-diphthamide biosynthetic process from peptidyl-histidine|endocytic recycling	molecular_function	endosome|cytoplasm
YDR317W	YDR317W	HIM1	hom	Verified	1.80217773188635	0.0357587235115431	no	342	0.0251711897814781	160	NA	FT	RESPONSE TO DNA DAMAGE			Protein of unknown function involved in DNA repair	DNA repair	molecular_function	cellular_component
YNL318C	YNL318C	HXT14	hom	Verified	1.80111693702837	0.0358422253613793	no	343	0.0271817377551017	142	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	hexose transport	galactose transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YHR180W_d	YHR180W	YHR180W	hom	Dubious	1.78903717351513	0.0368044145140088	no	344	0.029144515467426	162	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAL011W	YAL011W	SWC3	hom	Verified	1.78452936596201	0.0371688437092638	no	345	0.0604096144830382	341	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae	endoplasmic reticulum organization|chromatin remodeling|histone exchange	molecular_function	mitochondrion|Swr1 complex|nucleus
YBR267W	YBR267W	REI1	hom	Verified	1.7837338558952	0.0372334610123264	no	346	0.0675774765453651	318	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION		RIBOSOME	Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network	ribosomal large subunit biogenesis|nucleocytoplasmic transport|mitotic cell cycle|budding cell bud growth	sequence-specific DNA binding	cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YGL019W	YGL019W	CKB1	hom	Verified	1.77968604449753	0.0375636778083478	no	347	0.0661763356614527	302	NA	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases	regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein kinase regulator activity|protein serine/threonine kinase inhibitor activity	protein kinase CK2 complex|UTP-C complex
YNR037C	YNR037C	RSM19	hom	Verified	1.7745300259977	0.0379877600170593	no	348	0.0527235014400013	234	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YDR350C	YDR350C	ATP22	hom	Verified	1.76214953236177	0.0390220181642749	no	349	0.0433299748346692	182	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane	proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrial inner membrane
YER068W	YER068W	MOT2	hom	Verified	1.7576580583116	0.0394028541384098	no	350	0.047122618329856	187	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications	deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|protein polyubiquitination|protein ubiquitination	ubiquitin-protein ligase activity|sequence-specific DNA binding	CCR4-NOT core complex|cytoplasm
YNR041C	YNR041C	COQ2	hom	Verified	1.75666232696567	0.0394876912488295	no	351	0.0382992730485697	195	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis	ubiquinone biosynthetic process	4-hydroxybenzoate octaprenyltransferase activity	mitochondrion|integral to mitochondrial membrane|integral to membrane
YDR386W	YDR386W	MUS81	hom	Verified	1.75540767528368	0.0395948000776852	no	352	0.0624995772592863	302	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	crossover junction endodeoxyribonuclease activity|endonuclease activity	Holliday junction resolvase complex|nucleus
YHR192W	YHR192W	LNP1	hom	Verified	1.75440110315447	0.0396809012263889	no	353	0.0656694226261372	277	NA					Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS	endoplasmic reticulum tubular network organization	molecular_function	endoplasmic reticulum tubular network|cytoplasm
YGR010W	YGR010W	NMA2	hom	Verified	1.75340698683407	0.039766086287136	no	354	0.0422494658382857	159	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication	NAD biosynthetic process	nicotinamide-nucleotide adenylyltransferase activity	nucleus
YOR356W	YOR356W	CIR2	hom	Verified	1.75283854297872	0.0398148625769014	no	355	0.0373084378787078	201	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YCR017C	YCR017C	CWH43	hom	Verified	1.74839008411923	0.0401982518773606	no	356	0.0614643251527702	301	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion	fungal-type cell wall organization|GPI anchor biosynthetic process	molecular_function	integral to membrane|integral to plasma membrane|cellular bud neck|cellular bud tip
YHR100C	YHR100C	GEP4	hom	Verified	1.74387173173413	0.0405907294224954	no	357	0.0930261156830408	418	NA	FF|FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT	cardiolipin biosynthetic process|phosphorylated carbohydrate dephosphorylation	phosphatidylglycerophosphatase activity	mitochondrion|mitochondrial matrix
YDR217C	YDR217C	RAD9	hom	Verified	1.7397519640689	0.0409512902585767	no	358	0.0370905978626256	175	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate	DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of cell cycle|intra-S DNA damage checkpoint|nucleotide-excision repair|DNA damage checkpoint|positive regulation of transcription from RNA polymerase II promoter	double-stranded DNA binding|histone binding	chromatin|nucleus
YGR109C	YGR109C	CLB6	hom	Verified	1.73694535047828	0.0411984087665551	no	359	0.0350031204068024	159	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1	regulation of cyclin-dependent protein kinase activity|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|premeiotic DNA replication	cyclin-dependent protein kinase regulator activity	cellular_component
YDR522C	YDR522C	SPS2	hom	Verified	1.73634354670466	0.041251553869367	no	360	0.0320390772592546	201	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component	ascospore wall assembly|ascospore formation	molecular_function	fungal-type cell wall|plasma membrane
YKL181W	YKL181W	PRS1	hom	Verified	1.7360765200864	0.0412751527004412	no	361	0.0405069440464697	253	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YLR262C	YLR262C	YPT6	hom	Verified	1.73577278864405	0.0413020086711591	no	362	0.137550154591386	480	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	GOLGI APPARATUS|PLASMA MEMBRANE		Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6	intracellular protein transport|retrograde transport, endosome to Golgi	GTPase activity	Golgi apparatus
YCL061C	YCL061C	MRC1	hom	Verified	1.73503136256722	0.0413676251452194	no	363	0.0567943953344534	303	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres	maintenance of DNA repeat elements|intra-S DNA damage checkpoint|DNA repair|DNA replication checkpoint|telomere maintenance|replication fork protection|DNA replication|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	molecular_function	nuclear chromosome|replication fork protection complex|nucleus|nuclear replication fork
YGL043W	YGL043W	DST1	hom	Verified	1.73470484902944	0.0413965484948515	no	364	0.0408043794820385	243	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION	NUCLEUS		General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress	transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|mRNA cleavage|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|tRNA transcription from RNA polymerase III promoter|regulation of mRNA 3'-end processing|positive regulation of transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|transcription antitermination|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter	RNA polymerase II regulatory region DNA binding|RNA polymerase II core binding|core RNA polymerase II recruiting transcription factor activity	nucleus
YHR185C	YHR185C	PFS1	hom	Verified	1.73377831986527	0.0414787119094418	no	365	0.0472821273957041	213	NA	FT	CELL WALL ORG/BIOGENESIS	NUCLEUS|CYTOSKELETON		Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation	ascospore wall assembly	molecular_function	cellular_component
YIR027C	YIR027C	DAL1	hom	Verified	1.73332308377216	0.0415191300471163	no	366	0.0509979286559002	222	NA					Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression	allantoin assimilation pathway	allantoinase activity	cellular_component
YML009C-A_d	YML009C-A	YML009C-A	hom	Dubious	1.73030581440855	0.0417878256360644	no	367	0.0594784455224357	277	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL058W	YGL058W	RAD6	hom	Verified	1.72902716570449	0.0419021166121591	no	368	0.0444975419749279	199	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEOLYSIS|GENE SILENCING	NUCLEUS|CHROMOSOME		Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p	protein ubiquitination involved in ubiquitin-dependent protein catabolic process|histone monoubiquitination|protein monoubiquitination|error-free translesion synthesis|error-prone translesion synthesis|transcription from RNA polymerase II promoter|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of dipeptide transport|meiotic DNA double-strand break formation|ubiquitin-dependent protein catabolic process via the N-end rule pathway|double-strand break repair via homologous recombination|protein polyubiquitination|error-free postreplication DNA repair|chromatin silencing at telomere	ubiquitin-protein ligase activity	nuclear chromatin|proteasome complex|nucleus|cytoplasm
YDR422C	YDR422C	SIP1	hom	Verified	1.72785142822511	0.0420074321800414	no	369	0.0385447288528889	153	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION			Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions	signal transduction|protein phosphorylation|regulation of protein complex assembly	AMP-activated protein kinase activity	AMP-activated protein kinase complex|fungal-type vacuole
YNL307C	YNL307C	MCK1	hom	Verified	1.72765932684148	0.0420246598260566	no	370	0.0590456215451457	295	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION			Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family	meiosis|double-strand break repair via nonhomologous end joining|ascospore formation|protein phosphorylation|response to stress|mitotic sister chromatid segregation	protein serine/threonine/tyrosine kinase activity|protein serine/threonine kinase activity|protein kinase activity	cellular_component
YMR125W	YMR125W	STO1	hom	Verified	1.72347974465637	0.0424009025056639	no	371	0.0585201007307707	283	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|response to osmotic stress	mRNA binding	commitment complex|nuclear cap binding complex|polysome
YGR170W	YGR170W	PSD2	hom	Verified	1.7209878230374	0.0426265167818824	no	372	0.0427933126588147	226	NA	FT	LIPID METABOLISM	GOLGI APPARATUS		Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine	phosphatidylcholine biosynthetic process	phosphatidylserine decarboxylase activity	endosome
YDL179W	YDL179W	PCL9	hom	Verified	1.71925104067853	0.0427843352985734	no	373	0.0454691983947907	178	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p	regulation of establishment or maintenance of cell polarity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|cellular bud neck
YER058W	YER058W	PET117	hom	Verified	1.71831335232358	0.0428697376016461	no	374	0.0322031894345782	203	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein required for assembly of cytochrome c oxidase	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion
YMR155W_p	YMR155W	YMR155W	hom	Uncharacterized	1.71813658979699	0.0428858521117985	no	375	0.040663230821191	199	NA					Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen	biological_process	molecular_function	integral to membrane
YDR186C	YDR186C	YDR186C	hom	Verified	1.71689194577119	0.0429994583942013	no	376	0.0386714594601256	235	NA					Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	ribosome|cytoplasm
YGL063W	YGL063W	PUS2	hom	Verified	1.71640018608396	0.0430444112721829	no	377	0.0425079858705809	247	NA	FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion
YJL029C	YJL029C	VPS53	hom	Verified	1.71284733437387	0.0433703146746944	no	378	0.0345187546712376	205	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting	Golgi to vacuole transport|retrograde transport, endosome to Golgi	molecular_function	Golgi apparatus|GARP complex|cytoplasm
YIL039W	YIL039W	TED1	hom	Verified	1.71044485465057	0.0435918212901012	no	379	0.0699271917308636	327	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	ER to Golgi vesicle-mediated transport	molecular_function	endoplasmic reticulum
YDR174W	YDR174W	HMO1	hom	Verified	1.70931300367209	0.0436964929287292	no	380	0.0473389832911964	293	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase	regulation of transcription from RNA polymerase I promoter|regulation of transcription by chromatin organization|regulation of ribosomal protein gene transcription from RNA polymerase II promoter	double-stranded DNA binding|four-way junction DNA binding|DNA binding, bending	nuclear chromatin|nucleolus|cytoplasm
YNR031C	YNR031C	SSK2	hom	Verified	1.70867504082738	0.043755579947979	no	381	0.0415455368007805	224	NA	FT	SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress	MAPK cascade involved in osmosensory signaling pathway|protein autophosphorylation|protein phosphorylation|response to osmotic stress|actin cytoskeleton organization|osmosensory signaling pathway via two-component system	MAP kinase kinase kinase activity	cytosol|cellular bud neck|cellular bud tip
YNL220W	YNL220W	ADE12	hom	Verified	1.70748711882482	0.043865774993338	no	382	0.0324464598710092	159	NA	FT	NUCLEOTIDE METABOLISM			Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence	purine nucleotide biosynthetic process	DNA replication origin binding|adenylosuccinate synthase activity	cytoplasm
YDR159W	YDR159W	SAC3	hom	Verified	1.7067284012408	0.0439362728762055	no	383	0.0887508972463238	418	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)	ribosomal small subunit biogenesis|actin filament-based process|mRNA export from nucleus|mRNA 3'-end processing|mitosis|protein export from nucleus|transcription-coupled nucleotide-excision repair|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery	protein binding	transcription export complex 2|nuclear pore
YMR032W	YMR032W	HOF1	hom	Verified	1.70462563763414	0.0441321333491412	no	384	0.0460568128641299	307	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p	cytokinesis after mitosis|barrier septum assembly involved in cell cycle cytokinesis|response to DNA damage stimulus|cytokinesis	cytoskeletal protein binding	cellular bud neck contractile ring|cellular bud neck septin ring
YBR007C	YBR007C	DSF2	hom	Verified	1.70299726267844	0.0442842903343054	no	385	0.0525311736266744	352	NA	FF				Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cellular_component
YBL059W_p	YBL059W	YBL059W	hom	Uncharacterized	1.69579829188474	0.0449620430466422	no	386	0.0564743367530598	237	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion
YDR391C_p	YDR391C	YDR391C	hom	Uncharacterized	1.6955738406871	0.0449833076559106	no	387	0.0435168021452272	189	NA	FT		NUCLEUS		Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YDR079W	YDR079W	PET100	hom	Verified	1.69530267267119	0.0450090090348347	no	388	0.0511451991998262	239	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme	mitochondrial respiratory chain complex IV assembly|aerobic respiration	unfolded protein binding	mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YOR305W	YOR305W	RRG7	hom	Verified	1.69456663692973	0.0450788302877441	no	389	0.0411995260069732	229	NA	FT		MITOCHONDRION		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene	biological_process	molecular_function	mitochondrion
YGL127C	YGL127C	SOH1	hom	Verified	1.68707939003824	0.0457940437272772	no	390	0.056986570979175	291	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits	DNA repair|meiotic gene conversion|meiotic sister chromatid segregation|transcription from RNA polymerase II promoter	molecular_function	core mediator complex|nucleus
YEL024W	YEL024W	RIP1	hom	Verified	1.67763292976612	0.0467093900822886	no	391	0.068241696684168	286	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|mitochondrial respiratory chain complex III
YDR345C	YDR345C	HXT3	hom	Verified	1.67723565977265	0.0467482042258872	no	392	0.0611246499997709	291	NA	FT		PLASMA MEMBRANE		Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication	hexose transport|transmembrane transport	mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YDR176W	YDR176W	NGG1	hom	Verified	1.67442761453689	0.0470232947157302	no	393	0.0761008941769813	390	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex	histone acetylation|chromatin modification	histone acetyltransferase activity|transcription cofactor activity	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YGL059W	YGL059W	PKP2	hom	Verified	1.67371600141257	0.0470932137342954	no	394	0.0464727797973435	212	NA	FT	CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization|negative regulation of catalytic activity	protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity	mitochondrion
YBR179C	YBR179C	FZO1	hom	Verified	1.67350022518009	0.0471144311283988	no	395	0.0554774076561072	284	NA	FT	MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system	mitochondrial fusion	GTPase activity|protein homodimerization activity	mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YDR034W-B_p	YDR034W-B	YDR034W-B	hom	Uncharacterized	1.67006125839798	0.0474536220970585	no	396	0.0494037428954199	227	NA					Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YGR141W	YGR141W	VPS62	hom	Verified	1.66796838581852	0.0476610013788094	no	397	0.0377694579369273	170	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT			Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins	protein targeting to vacuole	molecular_function	cellular_component
YDR265W	YDR265W	PEX10	hom	Verified	1.66761019816665	0.0476965662338183	no	398	0.0463271839743912	239	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders	protein import into peroxisome matrix|protein ubiquitination	ubiquitin-protein ligase activity|protein binding	peroxisomal membrane
YBR212W	YBR212W	NGR1	hom	Verified	1.66700022209959	0.0477571803547495	no	399	0.0575232094943111	224	NA	FT	MITOCHONDRION ORGANIZATION			RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase	3'-UTR-mediated mRNA destabilization|mitochondrion organization	mRNA binding	cytoplasmic mRNA processing body|cytoplasmic stress granule|perinuclear region of cytoplasm|cytoplasm
YBL068W	YBL068W	PRS4	hom	Verified	1.66643115451364	0.0478137849463304	no	400	0.0256162154942283	161	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YLR201C	YLR201C	COQ9	hom	Verified	1.66236183983517	0.0482201226998087	no	401	0.0432622522174968	217	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes	ubiquinone biosynthetic process|aerobic respiration	molecular_function	mitochondrion|mitochondrial inner membrane
YBR146W	YBR146W	MRPS9	hom	Verified	1.66103985175729	0.0483527215951185	no	402	0.0533276028760142	242	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YDL085W	YDL085W	NDE2	hom	Verified	1.65285720961393	0.0491799637782366	no	403	0.0338206679047943	173	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain	glucose catabolic process to ethanol|NADH oxidation	NADH dehydrogenase activity	mitochondrion
YDR272W	YDR272W	GLO2	hom	Verified	1.64764128113137	0.049713152015138	no	404	0.0465946539836954	235	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM			Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate	cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate	hydroxyacylglutathione hydrolase activity	cytoplasm
YDR140W	YDR140W	MTQ2	hom	Verified	1.64688803714606	0.0497905306163061	no	405	0.0443847156496988	246	NA	FT	TRANSLATION	NUCLEUS		S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC	peptidyl-glutamine methylation|regulation of translation	protein methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity	eRF1 methyltransferase complex|nucleus|cytoplasm
YDL204W	YDL204W	RTN2	hom	Verified	1.63325629770383	0.0512075519972927	no	406	0.0715666821002866	297	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication	endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network maintenance	molecular_function	endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YER016W	YER016W	BIM1	hom	Verified	1.62740226920466	0.0518258449530214	no	407	0.046933522745685	263	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CHROMOSOME|CYTOSKELETON	KINETOCHORE	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally	nuclear migration along microtubule|microtubule nucleation|microtubule depolymerization|negative regulation of microtubule depolymerization|positive regulation of microtubule polymerization|mitotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint	microtubule plus-end binding|protein homodimerization activity|structural constituent of cytoskeleton	spindle midzone|microtubule plus end|cytoplasmic microtubule|spindle pole body|kinetochore|spindle pole|spindle
YHL038C	YHL038C	CBP2	hom	Verified	1.6273414164705	0.0518323031402314	no	408	0.0323088182846329	179	NA	FT	RNA PROCESSING	MITOCHONDRION		Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene	Group I intron splicing	RNA binding	mitochondrion
YOR001W	YOR001W	RRP6	hom	Verified	1.62604796556456	0.0519697260108995	no	409	0.0238602589507158	145	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay	nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U1 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear retention of pre-mRNA at the site of transcription|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription	3'-5'-exoribonuclease activity	nucleolus|nucleus|nuclear exosome (RNase complex)
YGL143C	YGL143C	MRF1	hom	Verified	1.62580382575436	0.0519956971273719	no	410	0.0900229291214955	328	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability	translational termination|mitochondrial translational termination|mitochondrial translation	translation release factor activity	mitochondrion
YLR056W	YLR056W	ERG3	hom	Verified	1.62512857544927	0.0520675826404868	no	411	0.0987721359702863	365	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase	ergosterol biosynthetic process	C-5 sterol desaturase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YCL050C	YCL050C	APA1	hom	Verified	1.62071338558134	0.0525395607737626	no	412	0.050161806653408	217	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication	nucleotide biosynthetic process|nucleoside catabolic process	bis(5'-nucleosyl)-tetraphosphatase activity|sulfate adenylyltransferase (ADP) activity	nucleus|cytoplasm
YER155C	YER155C	BEM2	hom	Verified	1.61897969923428	0.0527258155528802	no	413	0.0575225565416229	249	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence	negative regulation of Rho protein signal transduction|fungal-type cell wall organization|establishment of cell polarity|actin cytoskeleton organization	Rho GTPase activator activity	cell cortex|incipient cellular bud site|mitochondrion|plasma membrane|mating projection tip|cytoplasm|cellular bud tip
YGL107C	YGL107C	RMD9	hom	Verified	1.61817912831451	0.0528119997621325	no	414	0.0622285467064932	252	NA	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes	translational initiation|regulation of mRNA stability|aerobic respiration	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion
YLR204W	YLR204W	QRI5	hom	Verified	1.61204590018092	0.0534759759411267	no	415	0.0982569562030899	400	NA	FF|FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA	mRNA processing	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YPL013C	YPL013C	MRPS16	hom	Verified	1.60758181784171	0.0539633984916004	no	416	0.06869824091073	268	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YER015W	YER015W	FAA2	hom	Verified	1.60312172873804	0.0544538908203512	no	417	0.0551540464463586	285	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome	long-chain fatty acid metabolic process	long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|medium-chain fatty acid-CoA ligase activity	mitochondrion|peroxisome
YBL081W_p	YBL081W	YBL081W	hom	Uncharacterized	1.60219621234143	0.0545561136958255	no	418	0.0391761999716622	163	NA					Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport	biological_process	molecular_function	cellular_component
YDL065C	YDL065C	PEX19	hom	Verified	1.60085813587795	0.0547041718789137	no	419	0.0601039409419481	287	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning	protein stabilization|protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization|protein exit from endoplasmic reticulum	peroxisome membrane targeting sequence binding|protein binding	cytosol|peroxisomal membrane|endoplasmic reticulum
YGR097W	YGR097W	ASK10	hom	Verified	1.5974888583365	0.0550783896439685	no	420	0.0539128345345371	196	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS	RNA POL II, HOLOENZYME	Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication	cellular protein catabolic process|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glycerol transport	molecular_function	DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YOR013W_d	YOR013W	IRC11	hom	Dubious	1.59712179278521	0.0551192806349731	no	421	0.0380481449775834	221	NA					Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci	Unknown	Unknown	Unknown
YER031C	YER031C	YPT31	hom	Verified	1.59459246099576	0.055401699788204	no	422	0.101473300094053	433	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication	early endosome to Golgi transport|vesicle-mediated transport|exocytosis	GTPase activity	mitochondrial outer membrane|endosome|Golgi apparatus
YML115C	YML115C	VAN1	hom	Verified	1.58586640773127	0.0563848087380733	no	423	0.0959823795720025	372	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YOL140W	YOL140W	ARG8	hom	Verified	1.58553088699914	0.0564228824901563	no	424	0.0416949445134866	190	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine	arginine biosynthetic process|ornithine biosynthetic process	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	mitochondrion|mitochondrial matrix
YBL080C	YBL080C	PET112	hom	Verified	1.58467895840308	0.0565196474961331	no	425	0.0835183134182956	374	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog	glutaminyl-tRNAGln biosynthesis via transamidation|mitochondrial translation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YNL204C	YNL204C	SPS18	hom	Verified	1.58361421418434	0.0566407686375827	no	426	0.0659697776997155	305	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation	sporulation resulting in formation of a cellular spore	molecular_function	cellular_component
YIL002W-A_p	YIL002W-A	YIL002W-A	hom	Uncharacterized	1.58032410906264	0.057016330695698	no	427	0.0539783895178257	261	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YDR524C	YDR524C	AGE1	hom	Verified	1.58026664049298	0.0570229080521862	no	428	0.0185874459119651	127	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	GOLGI APPARATUS		ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport	phospholipid binding|ARF GTPase activator activity	endosome|trans-Golgi network|cytoplasm
YGR111W_p	YGR111W	YGR111W	hom	Uncharacterized	1.57723260865382	0.0573710062106869	no	429	0.0798153242317652	345	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	regulation of cell size	molecular_function	nucleus|cytoplasm
YDL180W_p	YDL180W	YDL180W	hom	Uncharacterized	1.57454383524397	0.0576808878626562	no	430	0.0563993179251972	249	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YDR255C	YDR255C	RMD5	hom	Verified	1.57376059632462	0.057771403415273	no	431	0.0486694927749693	251	NA	FT	KETONE METABOLISM|CELL CYCLE|CARBOHYDRATE METABOLISM|PROTEOLYSIS			Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	cytosol|GID complex
YBR119W	YBR119W	MUD1	hom	Verified	1.57278340361508	0.0578844899151298	no	432	0.0747296901519	281	NA	FT	RNA PROCESSING	NUCLEUS		U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing	mRNA splicing, via spliceosome	U1 snRNA binding|RNA binding	U1 snRNP|U2-type prespliceosome
YDR121W	YDR121W	DPB4	hom	Verified	1.57263903115151	0.0579012122909858	no	433	0.0748860611215089	278	NA	FT	GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization	DNA-dependent DNA replication|chromatin silencing at telomere	double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity	chromatin accessibility complex|epsilon DNA polymerase complex
YIL127C_p	YIL127C	RRT14	hom	Uncharacterized	1.56914368220157	0.0583072316655247	no	434	0.051663749072901	220	NA	FT		NUCLEUS		Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	nucleolus
YDR233C	YDR233C	RTN1	hom	Verified	1.5671581255531	0.0585388677778749	no	435	0.0430327125652774	210	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication	endoplasmic reticulum tubular network organization|endoplasmic reticulum organization|endoplasmic reticulum tubular network maintenance|nuclear pore complex assembly	molecular_function	integral to endoplasmic reticulum membrane|mitochondrion|Golgi apparatus|endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YDR197W	YDR197W	CBS2	hom	Verified	1.56536234647182	0.0587489859998129	no	436	0.0866116285604331	305	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader	mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial ribosome
YJR146W_p	YJR146W	YJR146W	hom	Uncharacterized	1.56505916597792	0.0587845184878604	no	437	0.0468450427248674	204	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2	biological_process	molecular_function	cellular_component
YLL006W	YLL006W	MMM1	hom	Verified	1.5644757044597	0.0588529471260379	no	438	0.0953535903209724	367	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth	mitochondrion organization|mitochondrial genome maintenance|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrion|integral to endoplasmic reticulum membrane|ERMES complex
YOR028C	YOR028C	CIN5	hom	Verified	1.56427632158914	0.0588763451661515	no	439	0.0438318679686516	195	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication	hyperosmotic salinity response|response to drug|hyperosmotic response|regulation of transcription from RNA polymerase II promoter	repressing transcription factor binding|sequence-specific DNA binding	nucleus|cytoplasm
YDR351W	YDR351W	SBE2	hom	Verified	1.5641009252725	0.0588969343632132	no	440	0.0609885631649797	284	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	GOLGI APPARATUS		Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth	fungal-type cell wall organization	molecular_function	Golgi apparatus
YBR133C	YBR133C	HSL7	hom	Verified	1.56264150482366	0.059068470078956	no	441	0.0760372065616333	353	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION	SITE OF POLARIZED GROWTH		Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress	G2/M transition of mitotic cell cycle|regulation of cell cycle	protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity	cellular bud neck
YEL042W	YEL042W	GDA1	hom	Verified	1.55930729542933	0.059461832925832	no	442	0.0541883444734905	242	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate	protein glycosylation	guanosine-diphosphatase activity|uridine-diphosphatase activity	Golgi apparatus
YDR400W	YDR400W	URH1	hom	Verified	1.55904030241173	0.0594934207744796	no	443	0.0488627468925106	181	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways	pyrimidine-containing compound salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|pyrimidine nucleoside catabolic process|nicotinate nucleotide salvage	ribosylpyrimidine nucleosidase activity|nicotinic acid riboside hydrolase activity|nicotinamide riboside hydrolase activity|uridine nucleosidase activity	nucleus|cytoplasm
YDR312W	YDR312W	SSF2	hom	Verified	1.55797145674143	0.0596200072630662	no	444	0.0375059365150352	179	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication	conjugation with cellular fusion|ribosomal large subunit assembly	rRNA binding	nucleolus
YDR369C	YDR369C	XRS2	hom	Verified	1.55656827566935	0.0597865103747485	no	445	0.0709060723317918	367	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling	double-strand break repair via nonhomologous end joining|meiotic DNA double-strand break formation|base-excision repair|telomere maintenance|sporulation resulting in formation of a cellular spore|double-strand break repair via break-induced replication	single-stranded telomeric DNA binding|protein binding, bridging|DNA binding|double-stranded telomeric DNA binding|telomeric DNA binding|G-quadruplex DNA binding	nucleus|Mre11 complex
YBL065W_d	YBL065W	YBL065W	hom	Dubious	1.55471800481741	0.0600066223055357	no	446	0.0683726282828481	250	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene	Unknown	Unknown	Unknown
YOR080W	YOR080W	DIA2	hom	Verified	1.55172937352499	0.0603634956273756	no	447	0.0671253767857058	281	NA	FT	CELL CYCLE|PROTEOLYSIS	NUCLEUS|CHROMOSOME	UBIQUITIN LIGASE COMPLEX	Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA replication|invasive growth in response to glucose limitation|protein ubiquitination	ubiquitin-protein ligase activity|DNA replication origin binding	SCF ubiquitin ligase complex|nucleus|nuclear replication fork
YJR082C	YJR082C	EAF6	hom	Verified	1.54764780399281	0.0608535576506795	no	448	0.0447118236311592	234	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3	DNA repair|histone acetylation	histone acetyltransferase activity	nucleus|NuA4 histone acetyltransferase complex|NuA3 histone acetyltransferase complex
YGR187C	YGR187C	HGH1	hom	Verified	1.5473392289796	0.0608907334632082	no	449	0.0582220327322071	268	NA					Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	cytoplasm
YFR023W	YFR023W	PES4	hom	Verified	1.54727627682252	0.0608983198532086	no	450	0.069571106761547	254	NA	FT		NUCLEUS		Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDR465C	YDR465C	RMT2	hom	Verified	1.54587165683144	0.0610677834507488	no	451	0.0795332517743408	241	NA	FT		NUCLEUS		Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress	peptidyl-arginine methylation	protein-arginine N5-methyltransferase activity	nucleus|cytoplasm
YEL031W	YEL031W	SPF1	hom	Verified	1.54432853905269	0.0612543810884386	no	452	0.114252918626856	511	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1	cellular calcium ion homeostasis|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	mitochondrion|integral to membrane|endoplasmic reticulum membrane|cis-Golgi network
YNR005C_d	YNR005C	YNR005C	hom	Dubious	1.54291265223923	0.061425985285938	no	453	0.0816056766643655	362	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL121C	YNL121C	TOM70	hom	Verified	1.54078654059897	0.0616843731245544	no	454	0.106494267388207	411	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication	protein import into mitochondrial matrix|protein import into mitochondrial inner membrane	mitochondrion targeting sequence binding|protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YDR154C_d	YDR154C	YDR154C	hom	Dubious	1.54018598856869	0.0617575121292514	no	455	0.0432299139689615	199	NA					Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein	Unknown	Unknown	Unknown
YGL250W	YGL250W	RMR1	hom	Verified	1.53505002689452	0.0623857700478381	no	456	0.0546815138316272	231	NA	FT	CELL CYCLE	NUCLEUS		Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus	meiotic gene conversion|reciprocal meiotic recombination	molecular_function	nucleus|cytoplasm
YGR076C	YGR076C	MRPL25	hom	Verified	1.53317649814237	0.0626161866256423	no	457	0.0759874284001833	329	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YNR020C	YNR020C	ATP23	hom	Verified	1.53184948659372	0.0627797905263725	no	458	0.0797610724147521	292	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p	protein processing|mitochondrial proton-transporting ATP synthase complex assembly	metalloendopeptidase activity	mitochondrial inner membrane|mitochondrial intermembrane space
YNL032W	YNL032W	SIW14	hom	Verified	1.53070501534131	0.0629211568486353	no	459	0.0606449022013552	311	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION			Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm	actin filament organization|endocytosis|protein dephosphorylation|response to stress	protein tyrosine phosphatase activity	cytoplasm
YDR137W	YDR137W	RGP1	hom	Verified	1.53005766224818	0.0630012283380885	no	460	0.14614896356911	501	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL DIVISION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p	retrograde transport, endosome to Golgi	guanyl-nucleotide exchange factor activity	Golgi apparatus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YJL059W	YJL059W	YHC3	hom	Verified	1.52892230709109	0.0631418527409776	no	461	0.0526459596149727	253	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)	basic amino acid transport|regulation of intracellular pH|arginine transport	molecular_function	integral to membrane|fungal-type vacuole
YDR101C	YDR101C	ARX1	hom	Verified	1.5270591334133	0.0633731538653489	no	462	0.0713679308032453	232	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS	NUCLEUS	RIBOSOME	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex	ribosomal large subunit biogenesis	molecular_function	nucleoplasm|cytosolic large ribosomal subunit|cytoplasm
YEL037C	YEL037C	RAD23	hom	Verified	1.52375534464058	0.0637849192159099	no	463	0.0620638248089976	251	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS|MITOCHONDRION		Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover	proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair, DNA damage recognition|ER-associated protein catabolic process|protein deglycosylation	damaged DNA binding|ubiquitin binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding, bridging	proteasome complex|mitochondrion|nucleotide-excision repair factor 2 complex
YBL094C_d	YBL094C	YBL094C	hom	Dubious	1.52342705427523	0.0638259488618931	no	464	0.0480270944100128	188	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W	Unknown	Unknown	Unknown
YGR161C_p	YGR161C	RTS3	hom	Uncharacterized	1.52272663504085	0.0639135556967551	no	465	0.0619576198188783	265	NA	FT		NUCLEUS		Putative component of the protein phosphatase type 2A complex	biological_process	molecular_function	nucleus|cytoplasm
YGR142W	YGR142W	BTN2	hom	Verified	1.52198577553173	0.0640063224487826	no	466	0.0617980536751386	281	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS			v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication	intracellular protein transport|amino acid transport|retrograde transport, endosome to Golgi|regulation of pH	SNARE binding	cytosol|late endosome|perinuclear region of cytoplasm
YDR126W	YDR126W	SWF1	hom	Verified	1.52134811304936	0.0640862511868285	no	467	0.0882803140348979	407	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|CYTOSKELETON		Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion	ascospore wall assembly|cortical actin cytoskeleton organization|establishment of cell polarity|vacuole fusion, non-autophagic|regulation of exocytosis|protein palmitoylation	palmitoyltransferase activity	integral to membrane|actin filament bundle|nuclear outer membrane-endoplasmic reticulum membrane network|actin cortical patch
YPR147C_p	YPR147C	YPR147C	hom	Uncharacterized	1.5211516393277	0.0641108941050599	no	468	0.0725015562113551	295	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cytoplasm
YDR529C	YDR529C	QCR7	hom	Verified	1.5205322078779	0.0641886351564958	no	469	0.0864885365624348	376	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration|mitochondrial respiratory chain complex III assembly	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YNL229C	YNL229C	URE2	hom	Verified	1.51837601025085	0.0644598178981637	no	470	0.120417203885915	491	NA	FF|FT	PROTEIN LOCALIZATION			Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion	regulation of nitrogen utilization|response to aluminum ion|protein urmylation|cytoplasmic sequestering of transcription factor	glutathione peroxidase activity|phosphoprotein binding|transcription corepressor activity	cytosol
YLR240W	YLR240W	VPS34	hom	Verified	1.51665986025862	0.0646762917945163	no	471	0.0698204227046242	340	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	GOLGI APPARATUS		Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery	peroxisome degradation|phosphatidylinositol phosphorylation|protein phosphorylation	1-phosphatidylinositol-3-kinase activity|protein kinase activity	endosome|fungal-type vacuole membrane|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|peroxisome|pre-autophagosomal structure
YDR216W	YDR216W	ADR1	hom	Verified	1.51605624417856	0.0647525655551683	no	472	0.0719779467284498	300	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING|PEROXISOME ORGANIZATION	NUCLEUS		Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization	negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|chromatin organization|regulation of transcription by chromatin organization|positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|peroxisome organization|positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|TFIIB-class transcription factor binding|sequence-specific DNA binding|TFIID-class transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	nucleus
YNR001C	YNR001C	CIT1	hom	Verified	1.51066543994315	0.0654368559432792	no	473	0.0733259887504529	356	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication	glutamate biosynthetic process|tricarboxylic acid cycle|acetyl-CoA catabolic process|citrate metabolic process	citrate (Si)-synthase activity	mitochondrion
YBR035C	YBR035C	PDX3	hom	Verified	1.50995154918381	0.0655278938131276	no	474	0.0583214983609136	318	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism	fatty acid metabolic process	pyridoxamine-phosphate oxidase activity	cellular_component
YER063W	YER063W	THO1	hom	Verified	1.50680061782227	0.065930885586443	no	475	0.0410941516219314	187	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation	poly(A)+ mRNA export from nucleus|transcription, DNA-dependent|ribonucleoprotein complex assembly	chromatin binding|double-stranded DNA binding|RNA binding	nucleus
YDL048C	YDL048C	STP4	hom	Verified	1.50101544552247	0.0666757833400697	no	476	0.0775887299164843	297	NA	FT		NUCLEUS|MITOCHONDRION		Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress	biological_process	sequence-specific DNA binding	mitochondrion|nucleus|cytoplasm
YGL086W	YGL086W	MAD1	hom	Verified	1.49372155990925	0.067624205474516	no	477	0.0603198207502503	250	NA	FT	CELL CYCLE|CELL DIVISION	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME	NUCLEAR PORE|KINETOCHORE	Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p	nucleocytoplasmic transport|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	nucleus|nuclear pore|kinetochore
YAR029W_p	YAR029W	YAR029W	hom	Uncharacterized	1.48116823591168	0.0692808741379474	no	478	0.0614870687772038	289	NA					Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YHR131C_p	YHR131C	YHR131C	hom	Uncharacterized	1.480622637889	0.0693535797311146	no	479	0.047196172907407	169	NA					Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study	biological_process	molecular_function	cytoplasm
YGR023W	YGR023W	MTL1	hom	Verified	1.47887031725095	0.0695874889455078	no	480	0.0634051845193373	210	NA	FT	CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	PLASMA MEMBRANE		Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p	cellular response to glucose starvation|fungal-type cell wall organization|cellular response to oxidative stress	molecular_function	integral to plasma membrane
YBL058W	YBL058W	SHP1	hom	Verified	1.47765282888791	0.0697503631575491	no	481	0.0599446701192695	205	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION	NUCLEUS		UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate	glycogen metabolic process|proteasomal ubiquitin-dependent protein catabolic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|ascospore formation|sister chromatid biorientation|autophagic vacuole assembly	protein phosphatase type 1 regulator activity	nucleus|cytoplasm
YNL274C	YNL274C	GOR1	hom	Verified	1.47734445843006	0.0697916631449914	no	482	0.0505604500641118	213	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS|MITOCHONDRION		Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	glyoxylate catabolic process|metabolic process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|glyoxylate reductase activity	mitochondrion|nucleus|cytoplasm
YGR059W	YGR059W	SPR3	hom	Verified	1.47537426180313	0.0700559755629567	no	483	0.0670400380653107	286	NA	FT	CELL CYCLE	SITE OF POLARIZED GROWTH|CYTOSKELETON		Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI	ascospore formation	structural molecule activity	septin complex|ascospore wall|prospore membrane
YNL064C	YNL064C	YDJ1	hom	Verified	1.47232746643341	0.0704662348446319	no	484	0.0470877443446646	193	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION			Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family	protein refolding|ER-associated protein catabolic process|protein targeting to mitochondrion|protein targeting to ER|'de novo' protein folding	unfolded protein binding|ATPase activator activity	cytosol|TRC complex|perinuclear region of cytoplasm
YDR157W_d	YDR157W	YDR157W	hom	Dubious	1.47198839666573	0.0705120054863577	no	485	0.0671544248004818	256	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL013W	YDL013W	SLX5	hom	Verified	1.4694046820347	0.0708615290766779	no	486	0.104211922404865	420	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers	protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination	SUMO binding|ubiquitin-protein ligase activity	ubiquitin ligase complex|nucleus
YDL154W	YDL154W	MSH5	hom	Verified	1.46743933229554	0.0711282907232149	no	487	0.058547554355212	274	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans	reciprocal meiotic recombination	molecular_function	nucleus
YDR264C	YDR264C	AKR1	hom	Verified	1.46646374873127	0.071260995099658	no	488	0.154648669077641	572	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication	protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation	palmitoyltransferase activity	integral to membrane|Golgi apparatus|membrane
YOR053W_d	YOR053W	YOR053W	hom	Dubious	1.46540581201956	0.071405116344308	no	489	0.0598299042312155	324	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C	Unknown	Unknown	Unknown
YDR297W	YDR297W	SUR2	hom	Verified	1.46197991520879	0.0718733569061798	no	490	0.0839552993427505	321	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis	sphingolipid metabolic process	sphingosine hydroxylase activity	integral to membrane|endoplasmic reticulum membrane
YJR130C	YJR130C	STR2	hom	Verified	1.46154912794933	0.0719324018012553	no	491	0.0639799437086872	281	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Cystathionine gamma-synthase, converts cysteine into cystathionine	sulfur compound metabolic process|transsulfuration	cystathionine gamma-synthase activity	nucleus|cytoplasm
YLL040C	YLL040C	VPS13	hom	Verified	1.46060350935222	0.0720621413303362	no	492	0.0726314655960313	316	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	MITOCHONDRION|GOLGI APPARATUS		Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively	protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole|ascospore-type prospore membrane assembly	molecular_function	endosome|mitochondrion|prospore membrane|extrinsic to membrane
YOL044W	YOL044W	PEX15	hom	Verified	1.46004571049476	0.0721387557974941	no	493	0.0579360113474349	265	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly	protein import into peroxisome matrix, receptor recycling	protein anchor	integral to peroxisomal membrane
YHR011W	YHR011W	DIA4	hom	Verified	1.4583066615616	0.072378017439791	no	494	0.0891143868052656	414	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth	pseudohyphal growth|invasive growth in response to glucose limitation|mitochondrial seryl-tRNA aminoacylation	serine-tRNA ligase activity	mitochondrion|cytoplasm
YGL163C	YGL163C	RAD54	hom	Verified	1.45208476617715	0.0732390185984486	no	495	0.122834187655527	434	NA	FF|FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS		DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress	positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|DNA translocase activity	nucleus
YLR419W_p	YLR419W	YLR419W	hom	Uncharacterized	1.45139895096983	0.0733344008473465	no	496	0.0679958772110558	273	NA	FT		MITOCHONDRION		Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene	biological_process	molecular_function	mitochondrion|cytoplasm
YDR300C	YDR300C	PRO1	hom	Verified	1.4486298311595	0.0737204928703415	no	497	0.077056998829348	292	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication	proline biosynthetic process	glutamate 5-kinase activity	cytoplasm
YDR320C	YDR320C	SWA2	hom	Verified	1.44465926850619	0.0742768080746089	no	498	0.132726936483416	484	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles	positive regulation of ATPase activity|endoplasmic reticulum inheritance|clathrin coat disassembly	ubiquitin binding|clathrin binding	endoplasmic reticulum membrane
YDR431W_d	YDR431W	YDR431W	hom	Dubious	1.44454502342279	0.0742928622631285	no	499	0.051133071240791	245	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR078C	YDR078C	SHU2	hom	Verified	1.43941847477003	0.0750159965212871	no	500	0.0743126249883553	323	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function	recombinational repair|maintenance of rDNA|error-free translesion synthesis	molecular_function	Shu complex
YGR205W	YGR205W	TDA10	hom	Verified	1.43915105186424	0.0750538651290324	no	501	0.0539191718796824	233	NA	FT		NUCLEUS		ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele	biological_process	ATP binding	nucleus|cytoplasm
YDR203W_d	YDR203W	YDR203W	hom	Dubious	1.43724100519522	0.0753247626710752	no	502	0.112644414118859	497	NA	FF				Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL166W	YJL166W	QCR8	hom	Verified	1.43664724155041	0.0754091264889405	no	503	0.0612624622029077	220	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YDR035W	YDR035W	ARO3	hom	Verified	1.43572272986466	0.075540627368318	no	504	0.164056280801896	649	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan	aromatic amino acid family biosynthetic process	3-deoxy-7-phosphoheptulonate synthase activity	mitochondrion|nucleus|cytoplasm
YOR008C	YOR008C	SLG1	hom	Verified	1.43495980349954	0.0756492761763757	no	505	0.146171285719786	548	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response	positive regulation of endocytosis|Rho protein signal transduction|actin cytoskeleton organization|fungal-type cell wall organization|response to heat|peroxisome degradation|establishment of cell polarity|response to osmotic stress	transmembrane signaling receptor activity	plasma membrane|mating projection tip|cellular bud neck
YIR033W	YIR033W	MGA2	hom	Verified	1.42976436674447	0.0763923296784756	no	506	0.0643012429906494	239	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	molecular_function	integral to endoplasmic reticulum membrane|nucleus
YDR329C	YDR329C	PEX3	hom	Verified	1.4281346438548	0.0766265538162775	no	507	0.0810281242439445	314	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	ENDOPLASMIC RETICULUM		Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p	protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization	protein binding	peroxisomal membrane|endoplasmic reticulum
YDR249C_p	YDR249C	YDR249C	hom	Uncharacterized	1.42765586209788	0.0766954681312737	no	508	0.0633656966263869	265	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR304C	YLR304C	ACO1	hom	Verified	1.42742899059775	0.0767281397430027	no	509	0.125933236975388	505	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy	propionate metabolic process|glutamate biosynthetic process|tricarboxylic acid cycle|mitochondrial genome maintenance|citrate metabolic process	double-stranded DNA binding|aconitate hydratase activity|single-stranded DNA binding	mitochondrial nucleoid|cytosol|mitochondrion|mitochondrial matrix
YOR374W	YOR374W	ALD4	hom	Verified	1.42692256876213	0.0768011073872956	no	510	0.063953413038011	248	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed	NADPH regeneration|ethanol metabolic process|pyruvate metabolic process|acetate biosynthetic process	aldehyde dehydrogenase [NAD(P)+] activity|aldehyde dehydrogenase (NAD) activity	mitochondrial nucleoid|mitochondrion
YDR383C	YDR383C	NKP1	hom	Verified	1.42650991380387	0.076860603658942	no	511	0.0819107165135618	322	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CHROMOSOME	KINETOCHORE	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4	biological_process	molecular_function	kinetochore
YOR311C	YOR311C	DGK1	hom	Verified	1.42555739131323	0.0769980713940353	no	512	0.0585123383227831	244	NA	FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain	phosphatidic acid biosynthetic process	diacylglycerol kinase activity	integral to endoplasmic reticulum membrane|integral to membrane
YDR221W	YDR221W	GTB1	hom	Verified	1.42253075836535	0.0774361144197969	no	513	0.0686081585312927	289	NA	FT	CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM		Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress	polysaccharide biosynthetic process|protein N-linked glycosylation	alpha-glucosidase activity	glucosidase II complex|endoplasmic reticulum|endoplasmic reticulum lumen
YLR371W	YLR371W	ROM2	hom	Verified	1.42249212716334	0.0774417177010088	no	514	0.182952884359483	614	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|NUCLEOTIDE METABOLISM	SITE OF POLARIZED GROWTH		GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p	regulation of fungal-type cell wall organization|positive regulation of endocytosis|establishment of cell polarity|small GTPase mediated signal transduction|negative regulation of cAMP-mediated signaling|activation of Rho GTPase activity	phosphatidylinositol-4,5-bisphosphate binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity	incipient cellular bud site|mating projection tip|cellular bud tip
YDL136W	YDL136W	RPL35B	hom	Verified	1.42213238593615	0.0774939113256625	no	515	0.0877629654012914	367	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication	cytoplasmic translation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic large ribosomal subunit|preribosome, large subunit precursor
YDR479C	YDR479C	PEX29	hom	Verified	1.41981305050496	0.0778310572794262	no	516	0.0829979694528424	314	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress	peroxisome organization	molecular_function	integral to membrane|peroxisomal membrane
YGR021W_p	YGR021W	YGR021W	hom	Uncharacterized	1.41840437173165	0.0780363700009248	no	517	0.0866204882429361	332	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YIR036C_p	YIR036C	IRC24	hom	Uncharacterized	1.41779912173436	0.0781247103353232	no	518	0.0798076727649425	341	NA	FT	OXIDATION-REDUCTION PROCESS			Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci	biological_process	molecular_function	integral to membrane|cytoplasm
YCL001W	YCL001W	RER1	hom	Verified	1.41717930638452	0.0782152551807726	no	519	0.0706928235799714	289	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER	protein retention in ER lumen|retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport	molecular_function	COPI-coated vesicle|integral to membrane|ER to Golgi transport vesicle
YPL017C	YPL017C	IRC15	hom	Verified	1.41687771109446	0.0782593420766572	no	520	0.105904695750164	428	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci	microtubule nucleation|mitotic recombination|microtubule anchoring|meiotic sister chromatid segregation|attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|positive regulation of mitotic cell cycle	microtubule binding|S-adenosylmethionine-dependent methyltransferase activity	microtubule|cytoplasm
YBR283C	YBR283C	SSH1	hom	Verified	1.41680985591631	0.0782692636748311	no	521	0.0751903087696465	302	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential	SRP-dependent cotranslational protein targeting to membrane	protein transmembrane transporter activity|signal sequence binding	integral to membrane|Ssh1 translocon complex
YBR171W	YBR171W	SEC66	hom	Verified	1.4162239884724	0.0783549672845238	no	522	0.171784281569393	646	NA	FF|FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	posttranslational protein targeting to membrane, translocation|filamentous growth	protein transporter activity	integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YDR022C	YDR022C	ATG31	hom	Verified	1.41405780331828	0.0786724656566523	no	523	0.0701871035557207	298	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion	autophagy|mitochondrion degradation|piecemeal microautophagy of nucleus	molecular_function	pre-autophagosomal structure|cytoplasm
YJR135C	YJR135C	MCM22	hom	Verified	1.41366420930277	0.0787302593675184	no	524	0.0626693021617571	263	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YDR225W	YDR225W	HTA1	hom	Verified	1.41306578276599	0.0788181914694389	no	525	0.0844325924222763	402	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME	RSC COMPLEX	Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p	DNA repair|chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter	DNA binding	replication fork protection complex|nuclear nucleosome
YDR375C	YDR375C	BCS1	hom	Verified	1.41230093309022	0.0789306858948415	no	526	0.093470051092198	345	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases	protein insertion into mitochondrial membrane from inner side|chaperone-mediated protein complex assembly|mitochondrial respiratory chain complex III assembly	protein transmembrane transporter activity|ATPase activity	mitochondrion|mitochondrial inner membrane
YKR067W	YKR067W	GPT2	hom	Verified	1.41045351234225	0.0792029069748912	no	527	0.0969099514931013	405	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen	phospholipid biosynthetic process	glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity	integral to membrane|lipid particle|endoplasmic reticulum|cytoplasm
YDL170W	YDL170W	UGA3	hom	Verified	1.40736530112608	0.0796595474194596	no	528	0.0754519285615721	271	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus	nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process	sequence-specific DNA binding transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YGR174C	YGR174C	CBP4	hom	Verified	1.40732059560428	0.0796661724262977	no	529	0.0734776991243612	307	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex	mitochondrial respiratory chain complex III assembly	molecular_function	mitochondrion|integral to mitochondrial membrane
YER071C_p	YER071C	TDA2	hom	Uncharacterized	1.40666344094519	0.0797636056840204	no	530	0.0660387638620636	215	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	mating projection tip|cytoplasm
YEL017W	YEL017W	GTT3	hom	Verified	1.40587553171527	0.0798805441016	no	531	0.0647826502844796	302	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery	biological_process	molecular_function	cellular_component
YNL041C	YNL041C	COG6	hom	Verified	1.40473781894362	0.0800496277035736	no	532	0.236429230232369	830	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YGR104C	YGR104C	SRB5	hom	Verified	1.39318063306653	0.0817825873630792	no	533	0.090216117390243	380	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance	transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly	core mediator complex
YGL198W	YGL198W	YIP4	hom	Verified	1.39163948017186	0.0820157986200466	no	534	0.0944612132742273	347	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YDL182W	YDL182W	LYS20	hom	Verified	1.39075593106867	0.0821497253471056	no	535	0.0586612644681212	240	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication	lysine biosynthetic process via aminoadipic acid	homocitrate synthase activity	mitochondrion|nucleus
YOR363C	YOR363C	PIP2	hom	Verified	1.38603636525912	0.0828678997786876	no	536	0.0826365302003005	322	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication	cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	integral to membrane|nucleus
YJL062W-A	YJL062W-A	COA3	hom	Verified	1.38546463901244	0.0829552189061609	no	537	0.0729223956211535	323	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly	mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation	molecular_function	mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YDL146W	YDL146W	LDB17	hom	Verified	1.38294670550917	0.0833406039093606	no	538	0.0627643802156284	256	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck	endocytosis	molecular_function	cellular bud|cellular bud neck|cytoplasm|actin cortical patch
YGL161C	YGL161C	YIP5	hom	Verified	1.38273346563996	0.0833733032788481	no	539	0.0886950273705119	366	NA	FT		GOLGI APPARATUS		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YOR024W_d	YOR024W	YOR024W	hom	Dubious	1.38264308105842	0.0833871662554276	no	540	0.0813649222808353	266	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL336W	YNL336W	COS1	hom	Verified	1.38056628008982	0.0837061786244291	no	541	0.0876399960354669	351	NA					Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YIL105C	YIL105C	SLM1	hom	Verified	1.37771313022466	0.0841459379053489	no	542	0.0790238108681141	307	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION	MITOCHONDRION|PLASMA MEMBRANE		Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol binding|sphingolipid binding	eisosome|mitochondrion|membrane raft|plasma membrane|cytoplasm
YDR230W_d	YDR230W	YDR230W	hom	Dubious	1.37541117351959	0.0845020034282398	no	543	0.0603376890329073	272	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20	Unknown	Unknown	Unknown
YDR338C_p	YDR338C	YDR338C	hom	Uncharacterized	1.37394086463956	0.0847300208981407	no	544	0.103864096682429	345	NA					Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily	transmembrane transport	antiporter activity	integral to membrane
YAR050W	YAR050W	FLO1	hom	Verified	1.37393870195513	0.0847303566296374	no	545	0.102854398889296	361	NA	FT		PLASMA MEMBRANE		Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p	cellular response to stress|flocculation via cell wall protein-carbohydrate interaction|flocculation	mannose binding	fungal-type cell wall
YLR192C	YLR192C	HCR1	hom	Verified	1.37318083077043	0.0848480687166395	no	546	0.123679407766473	469	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION			Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	translation initiation factor activity	eukaryotic translation initiation factor 3 complex
YOL118C_d	YOL118C	YOL118C	hom	Dubious	1.37066361964566	0.0852399203472636	no	547	0.0969404391844701	339	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR480W	YDR480W	DIG2	hom	Verified	1.37054245185733	0.0852588165576241	no	548	0.0763787649786408	316	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p	negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown	transcription factor binding	nucleus
YPL215W	YPL215W	CBP3	hom	Verified	1.36755536343649	0.0857256482335663	no	549	0.0647505543306299	289	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly	ribosome binding	integral to mitochondrial membrane|mitochondrion|mitochondrial ribosome
YBL087C	YBL087C	RPL23A	hom	Verified	1.36535479345345	0.0860707825243899	no	550	0.088032518187647	311	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOL111C	YOL111C	MDY2	hom	Verified	1.36152374496947	0.0866741174483538	no	551	0.116258312684466	494	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION	NUCLEUS		Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes	protein insertion into ER membrane|cell morphogenesis involved in conjugation with cellular fusion|posttranslational protein targeting to membrane	molecular_function	ribosome|TRC complex|nucleus|cytoplasm
YDR492W	YDR492W	IZH1	hom	Verified	1.36035807608733	0.0868583192275954	no	552	0.0826329014476486	367	NA	FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc	response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process	metal ion binding	integral to membrane|endoplasmic reticulum|membrane
YFL041W	YFL041W	FET5	hom	Verified	1.35985118420459	0.0869385106779584	no	553	0.0640950053228786	261	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS	PLASMA MEMBRANE		Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport	iron ion transport	ferroxidase activity	fungal-type vacuole membrane|integral to membrane
YKL016C	YKL016C	ATP7	hom	Verified	1.35957522717138	0.0869821909537549	no	554	0.0928615872233885	377	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	protein complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase, stator stalk|integral to membrane|mitochondrial proton-transporting ATP synthase complex
YMR257C	YMR257C	PET111	hom	Verified	1.35461313579654	0.0877704230624127	no	555	0.109793844500281	435	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrion|mitochondrial inner membrane
YDR462W	YDR462W	MRPL28	hom	Verified	1.34922562460145	0.0886322532687823	no	556	0.0944998335111389	414	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDR284C	YDR284C	DPP1	hom	Verified	1.34770645359758	0.0888764077852445	no	557	0.0843299588909118	345	NA	FT	LIPID METABOLISM|SIGNALING			Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism	phospholipid metabolic process|signal transduction	diacylglycerol diphosphate phosphatase activity|phosphatidate phosphatase activity	fungal-type vacuole membrane|integral to membrane
YHL029C_p	YHL029C	OCA5	hom	Uncharacterized	1.3468212756314	0.0890189004110276	no	558	0.117597254020651	473	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts	biological_process	molecular_function	cytoplasm
YBR223C	YBR223C	TDP1	hom	Verified	1.34564371006162	0.0892087239809222	no	559	0.0981439038141238	373	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI	DNA repair	3'-tyrosyl-DNA phosphodiesterase activity|5'-tyrosyl-DNA phosphodiesterase activity	nucleus
YGL234W	YGL234W	ADE5,7	hom	Verified	1.34392295395285	0.0894866512709574	no	560	0.0840322118143006	365	NA	FT	NUCLEOTIDE METABOLISM			Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities	purine nucleobase metabolic process|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity	cytoplasm
YJR079W_p	YJR079W	YJR079W	hom	Uncharacterized	1.34333921494472	0.0895810797971484	no	561	0.103166109485673	349	NA					Putative protein of unknown function; mutation results in impaired mitochondrial respiration	biological_process	molecular_function	cellular_component
YBR058C-A	YBR058C-A	TSC3	hom	Verified	1.34306614021906	0.0896252791536803	no	562	0.248803105153973	944	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis	3-keto-sphinganine metabolic process|sphingolipid biosynthetic process	enzyme activator activity	SPOTS complex
YDR310C	YDR310C	SUM1	hom	Verified	1.34085157945152	0.0899843228879107	no	563	0.104056312271173	366	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS		Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint	negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter during mitosis|DNA replication initiation|chromatin silencing at silent mating-type cassette	DNA replication origin binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus
YGL056C	YGL056C	SDS23	hom	Verified	1.33906562457901	0.0902746550165195	no	564	0.092960978141923	370	NA	FT	CELL DIVISION	NUCLEUS		One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication	cytokinetic cell separation	molecular_function	nucleus|cytoplasm
YBL003C	YBL003C	HTA2	hom	Verified	1.33881495650276	0.0903154602594625	no	565	0.0786633745656093	310	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p	DNA repair|chromatin assembly or disassembly	DNA binding	replication fork protection complex|nuclear nucleosome
YOR089C	YOR089C	VPS21	hom	Verified	1.33838880186746	0.090384863686787	no	566	0.157593462022872	597	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	MITOCHONDRION		Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication	endocytosis|vacuole inheritance|protein targeting to vacuole	GTP binding|GTPase activity	mitochondrial outer membrane|late endosome|mitochondrion
YJR032W	YJR032W	CPR7	hom	Verified	1.33699423930534	0.0906122586196592	no	567	0.103499678264473	398	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity	protein refolding|response to stress	unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity	cytosol
YER074W	YER074W	RPS24A	hom	Verified	1.3349378109072	0.0909483506306415	no	568	0.0903804410092672	369	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS|MITOCHONDRION	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|mitochondrion
YGR015C_p	YGR015C	YGR015C	hom	Uncharacterized	1.33309248814963	0.0912507271051531	no	569	0.103352546784588	381	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion
YJR075W	YJR075W	HOC1	hom	Verified	1.33211904223132	0.0914105369604477	no	570	0.0785401976938487	334	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele	cell wall mannoprotein biosynthetic process|substituted mannan metabolic process	alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups	alpha-1,6-mannosyltransferase complex
YMR036C	YMR036C	MIH1	hom	Verified	1.32984967773194	0.0917839021735277	no	571	0.0632931431718727	258	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25	G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	protein tyrosine phosphatase activity	nucleus|cytoplasm
YHR064C	YHR064C	SSZ1	hom	Verified	1.32953118473594	0.0918363922237874	no	572	0.0771255975346919	345	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION			Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP	cytoplasmic translation|regulation of translational fidelity|rRNA processing	unfolded protein binding	polysome|cytoplasm
YGR052W_p	YGR052W	FMP48	hom	Uncharacterized	1.32776498850435	0.0921278782854204	no	573	0.121066982364694	424	NA	FT	PROTEIN PHOSPHORYLATION	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation	protein phosphorylation	protein kinase activity	mitochondrion
YGR255C	YGR255C	COQ6	hom	Verified	1.32447293825746	0.0926730124194364	no	574	0.0971501185523628	397	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)	ubiquinone biosynthetic process	N,N-dimethylaniline monooxygenase activity	mitochondrion|mitochondrial inner membrane
YDR408C	YDR408C	ADE8	hom	Verified	1.32239741296667	0.0930179249404054	no	575	0.0989999640613518	377	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process|adenine biosynthetic process	phosphoribosylglycinamide formyltransferase activity	nucleus|cytoplasm
YDR266C	YDR266C	HEL2	hom	Verified	1.3198973212342	0.0934346510445098	no	576	0.0980720784315656	324	NA					RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor	biological_process	molecular_function	ribosome|cytoplasm
YEL065W	YEL065W	SIT1	hom	Verified	1.31681468374289	0.0939503748297589	no	577	0.0694839392629561	301	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p	cellular iron ion homeostasis|siderophore transport|transmembrane transport	siderophore uptake transmembrane transporter activity	endosome|integral to membrane|cytoplasmic membrane-bounded vesicle
YBL013W	YBL013W	FMT1	hom	Verified	1.31497189676356	0.0942596738035922	no	578	0.116855369538647	379	NA	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate	translational initiation|methionyl-tRNA aminoacylation	methionyl-tRNA formyltransferase activity	mitochondrion
YBR161W	YBR161W	CSH1	hom	Verified	1.31489101275839	0.0942732668068638	no	579	0.0730167075465951	338	NA	FT	LIPID METABOLISM			Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication	glycosphingolipid biosynthetic process|sphingolipid biosynthetic process	mannosyltransferase activity|transferase activity, transferring glycosyl groups	integral to membrane|fungal-type vacuole
YBR244W	YBR244W	GPX2	hom	Verified	1.3145394042997	0.0943323733513457	no	580	0.0724297590156046	335	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress	phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity	extrinsic to mitochondrial inner membrane|extrinsic to mitochondrial outer membrane|nucleus|cytoplasm
YHL001W	YHL001W	RPL14B	hom	Verified	1.31046392781641	0.0950194697512512	no	581	0.0897276396943995	349	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YOR239W	YOR239W	ABP140	hom	Verified	1.30930437773037	0.0952156336665069	no	582	0.0876176649634334	310	NA	FT	RNA PROCESSING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift	actin filament bundle assembly|tRNA methylation	tRNA (cytosine-3-)-methyltransferase activity|actin filament binding|protein binding, bridging	actin filament|actin filament bundle|mating projection tip|actin cortical patch
YHR139C-A_d	YHR139C-A	YHR139C-A	hom	Dubious	1.30839084791343	0.0953703876217895	no	583	0.085979315223151	369	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR099C_d	YBR099C	YBR099C	hom	Dubious	1.30822610256533	0.0953983155408402	no	584	0.0808058191490643	353	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4	Unknown	Unknown	Unknown
YFR026C	YFR026C	ULI1	hom	Verified	1.30444989556923	0.0960401161946053	no	585	0.0955292770789019	311	NA	FT	SIGNALING			Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response	endoplasmic reticulum unfolded protein response	molecular_function	cellular_component
YNL301C	YNL301C	RPL18B	hom	Verified	1.3039665696589	0.0961224904624985	no	586	0.0778725112129706	332	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGL060W	YGL060W	YBP2	hom	Verified	1.3030839708758	0.0962730476721366	no	587	0.10011763428348	456	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME	KINETOCHORE	Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication	G2/M transition of mitotic cell cycle	molecular_function	condensed nuclear chromosome kinetochore|centromere-specific nucleosome|cytoplasm
YBR201W	YBR201W	DER1	hom	Verified	1.3021146461103	0.0964385985763552	no	588	0.0972120956856052	390	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p	ER-associated protein catabolic process	molecular_function	integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YHR191C	YHR191C	CTF8	hom	Verified	1.29839728758423	0.0970754253617989	no	589	0.131377362235594	470	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion	maintenance of DNA trinucleotide repeats|mitotic sister chromatid cohesion	molecular_function	Ctf18 RFC-like complex
YGR085C	YGR085C	RPL11B	hom	Verified	1.29574776732018	0.0975311993131206	no	590	0.119786862837179	399	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome	cytosolic large ribosomal subunit
YGL226C-A	YGL226C-A	OST5	hom	Verified	1.29561338148527	0.0975543582886985	no	591	0.0941788282694814	381	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins	protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex
YOR086C	YOR086C	TCB1	hom	Verified	1.29553779523396	0.0975673859881816	no	592	0.0772823810751917	298	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact	biological_process	lipid binding	mitochondrion|plasma membrane|cortical endoplasmic reticulum
YMR272W-B_p	YMR272W-B	YMR272W-B	hom	Uncharacterized	1.29364913589976	0.0978933209820212	no	593	0.0652518590807742	260	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YPR131C	YPR131C	NAT3	hom	Verified	1.29361869040485	0.0978985816349447	no	594	0.0961650608369066	386	NA	FT	MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION			Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met	mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization	peptide alpha-N-acetyltransferase activity	NatB complex|cytoplasm
YJR104C	YJR104C	SOD1	hom	Verified	1.29244933216178	0.0981007909542406	no	595	0.209448749365955	733	NA	FF|FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid	cellular copper ion homeostasis|fungal-type cell wall organization|superoxide metabolic process|cellular zinc ion homeostasis|positive regulation of sequence-specific DNA binding transcription factor activity|age-dependent response to reactive oxygen species involved in chronological cell aging	superoxide dismutase activity	cytosol|mitochondrion|nucleus|mitochondrial intermembrane space
YDL083C	YDL083C	RPS16B	hom	Verified	1.2923096223006	0.0981249704976684	no	596	0.123801466238199	398	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YGR137W_d	YGR137W	YGR137W	hom	Dubious	1.29180422621691	0.0982124757109674	no	597	0.0907110957099802	356	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL002C	YDL002C	NHP10	hom	Verified	1.29144089592507	0.0982754186990603	no	598	0.111044028614802	442	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair	double-strand break repair|nucleosome mobilization	DNA end binding|loop DNA binding	nucleus|Ino80 complex
YGR152C	YGR152C	RSR1	hom	Verified	1.28828418747702	0.0988235277073949	no	599	0.0974205681644755	340	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases	bipolar cellular bud site selection|small GTPase mediated signal transduction|axial cellular bud site selection|cellular bud site selection	GTPase activity|signal transducer activity	plasma membrane|cellular bud neck
YNL055C	YNL055C	POR1	hom	Verified	1.28744146002244	0.0989702306526152	no	600	0.132968500038069	482	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication	DNA transport|mitochondrion organization|apoptotic process|ion transport|cell redox homeostasis	voltage-gated anion channel activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YDR504C	YDR504C	SPG3	hom	Verified	1.28561766952126	0.0992882635105586	no	601	0.0765567716707302	299	NA					Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	biological_process	molecular_function	cellular_component
YFL053W	YFL053W	DAK2	hom	Verified	1.28465420926529	0.0994565731774506	no	602	0.0850621395776496	346	NA	FT	CARBOHYDRATE METABOLISM			Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation	response to stress|glycerol catabolic process	glycerone kinase activity	cellular_component
YOR096W	YOR096W	RPS7A	hom	Verified	1.28157085941218	0.0999966140002851	no	603	0.132745899818035	463	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication	cytoplasmic translation|ribosome biogenesis	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YBR105C	YBR105C	VID24	hom	Verified	1.28027629476801	0.100223990820436	no	604	0.111642302914733	426	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles	negative regulation of gluconeogenesis|vesicle fusion with vacuole|vacuolar protein catabolic process|proteasomal ubiquitin-dependent protein catabolic process|vesicle-mediated transport|protein targeting to vacuole	molecular_function	cytoplasmic membrane-bounded vesicle|GID complex|extrinsic to membrane
YDR432W	YDR432W	NPL3	hom	Verified	1.27791970991489	0.100638868827452	no	605	0.128225679733237	520	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION	NUCLEUS		RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress	translational termination|mRNA export from nucleus|negative regulation of translation|mRNA splicing, via spliceosome|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter	mRNA binding|RNA polymerase II core binding|eukaryotic initiation factor 4G binding|poly(A) RNA binding	nucleus|cytoplasm
YGL045W	YGL045W	RIM8	hom	Verified	1.27763663089442	0.100688789191939	no	606	0.138516740721653	542	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family	meiosis|protein processing|invasive growth in response to glucose limitation|ubiquitin-dependent endocytosis	molecular_function	internal side of plasma membrane
YHR075C	YHR075C	PPE1	hom	Verified	1.27665758865116	0.100861580389149	no	607	0.0973359804406501	380	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein	cellular protein modification process|mitochondrial translation	structural constituent of ribosome|carboxylesterase activity	mitochondrial small ribosomal subunit
YDR179W-A_p	YDR179W-A	YDR179W-A	hom	Uncharacterized	1.27524809074924	0.101110722264876	no	608	0.101072548793774	369	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJR149W_p	YJR149W	YJR149W	hom	Uncharacterized	1.27300732773133	0.101507720806558	no	609	0.0718544616396558	252	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YOR026W	YOR026W	BUB3	hom	Verified	1.27226654496515	0.101639215502314	no	610	0.0997703231001335	418	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME	KINETOCHORE	Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p	mitotic cell cycle G2/M transition decatenation checkpoint|mitotic cell cycle spindle assembly checkpoint	ubiquitin binding	mitotic checkpoint complex|condensed nuclear chromosome kinetochore
YDR043C	YDR043C	NRG1	hom	Verified	1.27085309078858	0.101890458626133	no	611	0.0818590493020984	310	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter by glucose|cellular hyperosmotic salinity response|biofilm formation|negative regulation of transcription from RNA polymerase II promoter|pseudohyphal growth|Unknown	RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nucleus
YER005W	YER005W	YND1	hom	Verified	1.26759080113005	0.102472059332487	no	612	0.102245485705979	410	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity	protein glycosylation	nucleoside-triphosphatase activity|nucleoside-diphosphatase activity	COPI-coated vesicle|Golgi apparatus|membrane|Golgi membrane
YIR018W	YIR018W	YAP5	hom	Verified	1.26747427243812	0.10249287861553	no	613	0.089898002468142	359	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS|CHROMOSOME		Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication	negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to iron|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nuclear chromatin|nucleus
YBR106W	YBR106W	PHO88	hom	Verified	1.2670977319919	0.102560173218043	no	614	0.17865080139771	667	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations	phosphate ion transport	molecular_function	mitochondrion|membrane
YDR260C	YDR260C	SWM1	hom	Verified	1.26634545931695	0.102694714157929	no	615	0.106171421779408	383	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation	ascospore wall assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of mitotic metaphase/anaphase transition|protein ubiquitination	molecular_function	anaphase-promoting complex|nucleus
YDR357C_p	YDR357C	CNL1	hom	Uncharacterized	1.26405034472708	0.103105978750324	no	616	0.0881203439237182	322	NA					Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	BLOC-1 complex|cytoplasm
YBL015W	YBL015W	ACH1	hom	Verified	1.26340241322275	0.103222298665477	no	617	0.0900636880091708	275	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth	acetate metabolic process	acetate CoA-transferase activity|acetyl-CoA hydrolase activity	cytosol|mitochondrion
YKL110C	YKL110C	KTI12	hom	Verified	1.26279012440346	0.103332307368612	no	618	0.118182668810827	451	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p	regulation of transcription from RNA polymerase II promoter|cell growth|tRNA wobble uridine modification	chromatin binding	nucleus|cytoplasm
YDL237W	YDL237W	AIM6	hom	Verified	1.26161903554755	0.103542951586876	no	619	0.107231326824279	370	NA					Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene	biological_process	molecular_function	cellular_component
YLR421C	YLR421C	RPN13	hom	Verified	1.26105256552537	0.103644954526764	no	620	0.112089454723618	426	NA	FT	PROTEOLYSIS	NUCLEUS		Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress	ubiquitin-dependent protein catabolic process	ubiquitin binding	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YDR380W	YDR380W	ARO10	hom	Verified	1.25882490439059	0.104046791423152	no	621	0.0855012256744934	322	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway	L-phenylalanine catabolic process|methionine catabolic process to 3-methylthiopropanol|tryptophan catabolic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway|leucine catabolic process	pyruvate decarboxylase activity|carboxy-lyase activity|phenylpyruvate decarboxylase activity	cytoplasm
YFR021W	YFR021W	ATG18	hom	Verified	1.25833395196824	0.10413550363962	no	622	0.110657669283831	425	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|VACUOLAR PROTEIN PROCESSING			Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood	piecemeal microautophagy of nucleus|peroxisome degradation|vacuolar protein processing|macroautophagy|late endosome to vacuole transport|CVT pathway	ubiquitin binding|phosphatidylinositol binding	cytosol|endosome|fungal-type vacuole membrane|PAS complex|pre-autophagosomal structure
YHL031C	YHL031C	GOS1	hom	Verified	1.25832271652252	0.104137534460215	no	623	0.179014718507662	658	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28	Golgi vesicle transport|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|Golgi medial cisterna
YGL223C	YGL223C	COG1	hom	Verified	1.25793104274436	0.104208347923544	no	624	0.158617760864637	524	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YDL116W	YDL116W	NUP84	hom	Verified	1.25694717998558	0.104386381354209	no	625	0.103416722092265	457	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107	double-strand break repair|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|maintenance of chromatin silencing at telomere|nuclear pore distribution|telomere tethering at nuclear periphery|response to DNA damage stimulus|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	structural constituent of nuclear pore	integral to membrane|nuclear pore outer ring|nuclear pore
YDR433W_d	YDR433W	YDR433W	hom	Dubious	1.25619086222594	0.10452338947954	no	626	0.12209929728152	503	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR358W	YOR358W	HAP5	hom	Verified	1.255284233393	0.104687798316411	no	627	0.0933100960631554	360	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex
YCL026C-B	YCL026C-B	HBN1	hom	Verified	1.25419803351238	0.104885017235222	no	628	0.116602419578736	456	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress	biological_process	NAD(P)H nitroreductase activity	nucleus|cytoplasm
YLR059C	YLR059C	REX2	hom	Verified	1.25371486129218	0.104972832139604	no	629	0.115068129028111	399	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease	U5 snRNA 3'-end processing|U4 snRNA 3'-end processing|mitochondrial genome maintenance|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3'-5'-exoribonuclease activity|3'-5' exonuclease activity	mitochondrion
YPL249C-A	YPL249C-A	RPL36B	hom	Verified	1.25335765570399	0.105037787247756	no	630	0.0799172425643225	359	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YDR518W	YDR518W	EUG1	hom	Verified	1.25111922256681	0.105445491662808	no	631	0.0968860640488935	401	NA	FT		ENDOPLASMIC RETICULUM		Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER	protein folding	protein disulfide isomerase activity|protein disulfide oxidoreductase activity	endoplasmic reticulum
YDR309C	YDR309C	GIC2	hom	Verified	1.24969799407753	0.10570494518471	no	632	0.0881410081657224	345	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region	regulation of exit from mitosis|establishment of cell polarity|axial cellular bud site selection|Rho protein signal transduction	Rho GTPase binding|Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding	incipient cellular bud site|actin cap|plasma membrane|mating projection tip|cellular bud tip
YAL023C	YAL023C	PMT2	hom	Verified	1.24956261091302	0.105729684224016	no	633	0.13852147717612	502	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication	ER-associated misfolded protein catabolic process|protein O-linked glycosylation|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YNL089C_d	YNL089C	YNL089C	hom	Dubious	1.24928299155909	0.105780793296672	no	634	0.103757450318133	430	NA					Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins	Unknown	Unknown	Unknown
YBL039C	YBL039C	URA7	hom	Verified	1.24903315966684	0.10582647289536	no	635	0.112851945483771	443	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication	pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process	CTP synthase activity	cytosol
YDL045W-A	YDL045W-A	MRP10	hom	Verified	1.24749966382853	0.106107171713747	no	636	0.143209150748322	468	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs	mitochondrial translation|mitochondrial respiratory chain complex assembly	structural constituent of ribosome	mitochondrial small ribosomal subunit
YER061C	YER061C	CEM1	hom	Verified	1.247370364979	0.106130863793333	no	637	0.12694253965804	490	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration	fatty acid biosynthetic process	fatty acid synthase activity	mitochondrion
YHR142W	YHR142W	CHS7	hom	Verified	1.24706098344927	0.106187568841479	no	638	0.235734139610636	782	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress	protein folding|ER to Golgi vesicle-mediated transport|fungal-type cell wall chitin biosynthetic process	unfolded protein binding	integral to membrane|endoplasmic reticulum membrane
YOR351C	YOR351C	MEK1	hom	Verified	1.24561343234791	0.106453174257548	no	639	0.0921619428290418	389	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	NUCLEUS		Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids	meiosis|meiotic recombination checkpoint|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	nucleus
YGL231C	YGL231C	EMC4	hom	Verified	1.24484098487765	0.10659510370522	no	640	0.128722652176	443	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YDR256C	YDR256C	CTA1	hom	Verified	1.24220404277669	0.107080644219878	no	641	0.101847540244454	378	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation	response to reactive oxygen species|age-dependent response to reactive oxygen species|hydrogen peroxide catabolic process	catalase activity	peroxisomal matrix|mitochondrial matrix
YMR151W_d	YMR151W	YIM2	hom	Dubious	1.24200475390061	0.10711740403287	no	642	0.101435394642209	365	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1	Unknown	Unknown	Unknown
YGR161W-C_p	YGR161W-C	YGR161W-C	hom	Uncharacterized	1.24125786113125	0.107255253042623	no	643	0.0739197347103911	282	NA					Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	cellular_component
YDR220C_d	YDR220C	YDR220C	hom	Dubious	1.23855167384493	0.107755787144665	no	644	0.0883556897048701	335	NA					Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein	Unknown	Unknown	Unknown
YKL114C	YKL114C	APN1	hom	Verified	1.23816381473261	0.107827662876407	no	645	0.155340848814003	602	NA	FF|FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine	base-excision repair	3'-tyrosyl-DNA phosphodiesterase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity	mitochondrion|nucleus
YER107C	YER107C	GLE2	hom	Verified	1.23602993375691	0.108223718586889	no	646	0.163265996694664	615	NA	FF|FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1	poly(A)+ mRNA export from nucleus|Unknown|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear pore distribution|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	molecular_function	integral to membrane|nuclear pore|cytoplasm
YJR110W	YJR110W	YMR1	hom	Verified	1.2352463397664	0.108369418875596	no	647	0.108368526868235	407	NA	FT	LIPID METABOLISM			Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family	phosphatidylinositol dephosphorylation	mRNA binding|phosphatidylinositol-3-phosphatase activity	cytoplasm
YDR033W	YDR033W	MRH1	hom	Verified	1.23511018904786	0.108394748921885	no	648	0.108428447899675	417	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane|plasma membrane
YNL130C-A_p	YNL130C-A	DGR1	hom	Uncharacterized	1.23510723395022	0.108395298747781	no	649	0.0914598997630404	405	NA	FT		MITOCHONDRION		Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose	biological_process	molecular_function	cellular_component
YEL062W	YEL062W	NPR2	hom	Verified	1.23104412096788	0.109153181516393	no	650	0.125771818801371	462	NA	FT	SIGNALING|RESPONSE TO NUTRIENT LEVELS			Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline	proline transport|urea transport|regulation of TOR signaling cascade|cellular response to amino acid starvation|response to drug|cellular response to nitrogen starvation	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YPR139C	YPR139C	LOA1	hom	Verified	1.23103204324854	0.109155440006433	no	651	0.146808462735027	503	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA	lipid particle organization|cellular triglyceride homeostasis|protein targeting to vacuole	lysophosphatidic acid acyltransferase activity	endoplasmic reticulum|lipid particle|cytoplasm
YJR127C	YJR127C	RSF2	hom	Verified	1.23012842469918	0.109324508672558	no	652	0.0715767996480265	286	NA	FT		NUCLEUS		Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YHR001W-A	YHR001W-A	QCR10	hom	Verified	1.22963017870399	0.10941781182029	no	653	0.0930297448734144	379	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|mitochondrial respiratory chain complex III
YNR004W_p	YNR004W	SWM2	hom	Uncharacterized	1.22901847152015	0.109532440271273	no	654	0.103179533887939	402	NA	FT		NUCLEUS		Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds	biological_process	molecular_function	nucleolus
YLR004C	YLR004C	THI73	hom	Verified	1.22876406683037	0.109580138814562	no	655	0.0908793092704686	294	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs	transport	transporter activity	integral to membrane|endoplasmic reticulum
YBR101C	YBR101C	FES1	hom	Verified	1.22733478600793	0.109848393135311	no	656	0.10853657241414	421	NA	FT	TRANSLATION		RIBOSOME	Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	cytoplasmic translation	adenyl-nucleotide exchange factor activity	cytosol|cytosolic ribosome
YDR323C	YDR323C	PEP7	hom	Verified	1.226169790294	0.110067393543582	no	657	0.180425385697597	659	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance	Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol-3-phosphate binding	external side of endosome membrane|cytoplasm
YOR295W	YOR295W	UAF30	hom	Verified	1.22487073076462	0.110311964967913	no	658	0.103882923578462	427	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|chromatin organization	RNA polymerase I upstream control element sequence-specific DNA binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity	nucleolus|RNA polymerase I upstream activating factor complex
YGR131W	YGR131W	FHN1	hom	Verified	1.22378680377352	0.11051633185699	no	659	0.118122750601209	418	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain	establishment of protein localization to plasma membrane	molecular_function	integral to membrane|membrane raft
YDR295C	YDR295C	HDA2	hom	Verified	1.22265353077698	0.110730292671119	no	660	0.0917442334636789	324	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance	negative regulation of transcription from RNA polymerase II promoter|gene silencing by RNA|histone deacetylation|gene silencing involved in chronological cell aging	histone deacetylase activity|chromatin binding|DNA binding	nucleus|HDA1 complex
YOL020W	YOL020W	TAT2	hom	Verified	1.21946516963224	0.111333843959874	no	661	0.127611377171849	480	NA	FT		PLASMA MEMBRANE		High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance	aromatic amino acid transport|tryptophan transport	high-affinity tryptophan transmembrane transporter activity|aromatic amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YDL231C	YDL231C	BRE4	hom	Verified	1.21934316587734	0.111356985748788	no	662	0.113664719337636	407	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport	endocytosis	molecular_function	integral to membrane
YAR031W	YAR031W	PRM9	hom	Verified	1.21716334679244	0.111771036365162	no	663	0.117038399805793	389	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family	vesicle organization	molecular_function	integral to membrane|endoplasmic reticulum|plasma membrane
YGR200C	YGR200C	ELP2	hom	Verified	1.21603833603947	0.111985159353378	no	664	0.133401279000034	492	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin	regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YGR121C	YGR121C	MEP1	hom	Verified	1.21586101942453	0.112018934714562	no	665	0.102336569262878	355	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation	nitrogen utilization|ammonium transport	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YFL056C	YFL056C	AAD6	hom	Verified	1.21382653953036	0.11240698476588	no	666	0.107777578564732	419	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YLR048W	YLR048W	RPS0B	hom	Verified	1.21329001020234	0.112509480466779	no	667	0.0907682099743139	379	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR335W	YDR335W	MSN5	hom	Verified	1.20984307804194	0.113169556373485	no	668	0.130684545185203	489	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|protein export from nucleus	protein binding|importin-alpha export receptor activity	integral to membrane|nucleus|cytoplasm
YNL205C_d	YNL205C	YNL205C	hom	Dubious	1.20801351743379	0.113521031459184	no	669	0.117329824678546	460	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR014W	YDR014W	RAD61	hom	Verified	1.20739515089762	0.113640001056647	no	670	0.135648426654685	491	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin	mitotic sister chromatid cohesion	molecular_function	nuclear cohesin complex
YNR042W_d	YNR042W	YNR042W	hom	Dubious	1.19517567062825	0.116009201010738	no	671	0.0995547965935586	363	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2	Unknown	Unknown	Unknown
YJL095W	YJL095W	BCK1	hom	Verified	1.19374649028295	0.116288574411376	no	672	0.213843642311984	780	NA	FF|FT	SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH		Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p	intracellular protein kinase cascade|endoplasmic reticulum unfolded protein response|peroxisome degradation|establishment of cell polarity|protein phosphorylation|response to acid|response to nutrient	protein kinase activity|MAP kinase kinase kinase activity	intracellular|mating projection tip
YDR136C_d	YDR136C	VPS61	hom	Dubious	1.19235123569584	0.116561776257127	no	673	0.228773705886767	746	NA	FF				Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YDR533C	YDR533C	HSP31	hom	Verified	1.19226498430871	0.11657867988542	no	674	0.144782994725324	538	NA	FT	PROTEOLYSIS			Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress	biological_process	unfolded protein binding|cysteine-type peptidase activity	cellular_component
YDL112W	YDL112W	TRM3	hom	Verified	1.1913628462322	0.116755585946488	no	675	0.128983587542648	435	NA	FT	RNA PROCESSING			2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs	tRNA methylation	tRNA (guanine) methyltransferase activity	cytoplasm
YCR068W	YCR068W	ATG15	hom	Verified	1.19023202025487	0.116977605581427	no	676	0.140830856792758	529	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway	membrane disassembly|autophagy|piecemeal microautophagy of nucleus|vacuolar protein processing|multivesicular body membrane disassembly	lipase activity	integral to membrane|vacuolar lumen
YFL018C	YFL018C	LPD1	hom	Verified	1.18966881219592	0.117088294041554	no	677	0.119854386129734	479	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes	L-serine biosynthetic process|2-oxoglutarate metabolic process|leucine catabolic process|glycine catabolic process|isoleucine catabolic process|pyruvate metabolic process|valine catabolic process|hydrogen peroxide metabolic process	glycine dehydrogenase (decarboxylating) activity|pyruvate dehydrogenase activity|oxoglutarate dehydrogenase (succinyl-transferring) activity|dihydrolipoyl dehydrogenase activity	mitochondrial nucleoid|mitochondrion|glycine cleavage complex|mitochondrial oxoglutarate dehydrogenase complex
YPL056C_p	YPL056C	LCL1	hom	Uncharacterized	1.18955275699795	0.117111111831217	no	678	0.126713729511993	458	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan	biological_process	molecular_function	cellular_component
YOR010C	YOR010C	TIR2	hom	Verified	1.18754023763704	0.117507297427073	no	679	0.0919344814270623	317	NA					Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis	response to stress	molecular_function	fungal-type cell wall
YDL213C	YDL213C	NOP6	hom	Verified	1.18678571473546	0.117656077492061	no	680	0.124610487435745	462	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes	ribosomal small subunit biogenesis	RNA binding|rRNA binding	nucleolus|90S preribosome
YDR223W	YDR223W	CRF1	hom	Verified	1.18396997840197	0.118212473542931	no	681	0.118656249084808	409	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS	NUCLEUS|CHROMOSOME		Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter	transcription corepressor activity	nuclear chromatin|nucleus|cytoplasm
YOL164W	YOL164W	BDS1	hom	Verified	1.1838815728909	0.118229972751512	no	682	0.137201626858514	522	NA					Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources	dodecyl sulfate metabolic process	arylsulfatase activity|alkyl sulfatase activity	cellular_component
YPL047W	YPL047W	SGF11	hom	Verified	1.18235190716057	0.118533048693919	no	683	0.114883899849124	454	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation	histone deubiquitination|regulation of transcription from RNA polymerase II promoter	enzyme activator activity	DUBm complex|nucleus|SAGA complex
YKL065C	YKL065C	YET1	hom	Verified	1.18104072674976	0.118793272353364	no	684	0.0955850162484985	350	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein	biological_process	molecular_function	ribosome|integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YOL152W	YOL152W	FRE7	hom	Verified	1.17837219858961	0.11932412806908	no	685	0.12198326521506	426	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YCR034W	YCR034W	FEN1	hom	Verified	1.17755017535364	0.119487991584939	no	686	0.197791643494634	696	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication	fatty acid elongation|vesicle-mediated transport|sphingolipid biosynthetic process	fatty acid elongase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YDR307W_p	YDR307W	PMT7	hom	Uncharacterized	1.17750609997205	0.119496782128912	no	687	0.111928012504188	399	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YDR005C	YDR005C	MAF1	hom	Verified	1.17580872119805	0.119835660286105	no	688	0.138931385632994	514	NA	FT		NUCLEUS		Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions	negative regulation of transcription from RNA polymerase III promoter	RNA polymerase III core binding	nucleolus|nucleus|cytoplasm
YNR051C	YNR051C	BRE5	hom	Verified	1.17445025407816	0.120107363152182	no	689	0.120683990113239	486	NA	FT	VESICLE-MEDIATED TRANSPORT			Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown	molecular_function	cytoplasm
YBR230C	YBR230C	OM14	hom	Verified	1.17406308308655	0.120184879475802	no	690	0.133980226907171	463	NA	FT		MITOCHONDRION		Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron	biological_process	molecular_function	mitochondrion|integral to mitochondrial outer membrane
YJR103W	YJR103W	URA8	hom	Verified	1.17256054931174	0.120486038769118	no	691	0.0925853480924443	302	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication	pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process	CTP synthase activity	cytosol
YOR320C	YOR320C	GNT1	hom	Verified	1.16880235522608	0.121241635627716	no	692	0.115072249415384	404	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus	protein N-linked glycosylation	acetylglucosaminyltransferase activity	Golgi medial cisterna
YDR152W	YDR152W	GIR2	hom	Verified	1.16789805270577	0.121423944861221	no	693	0.123389379998611	469	NA	FT	TRANSLATION			Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein	cytoplasmic translation	molecular_function	polysome|cytoplasm
YOR381W	YOR381W	FRE3	hom	Verified	1.16715891717883	0.121573099168587	no	694	0.123615217012501	432	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels	cellular iron ion homeostasis|siderophore transport	ferric-chelate reductase activity	integral to membrane|plasma membrane
YGR139W_d	YGR139W	YGR139W	hom	Dubious	1.16709057628307	0.121586896562584	no	695	0.0919889374736924	365	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR054W	YGR054W	YGR054W	hom	Verified	1.16527669872183	0.12195350395859	no	696	0.117520420758961	422	NA	FT	TRANSLATION			Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A	translational initiation	translation initiation factor activity	cytosolic ribosome|cytosolic small ribosomal subunit|ribosome
YMR242W-A_p	YMR242W-A	YMR242W-A	hom	Uncharacterized	1.16467652922325	0.122074976510803	no	697	0.118611879858527	438	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL139C	YNL139C	THO2	hom	Verified	1.16316064573874	0.122382165134294	no	698	0.159685682741083	521	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	NUCLEUS		Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids	mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|DNA recombination|transcription elongation from RNA polymerase II promoter	DNA binding|nucleic acid binding	THO complex part of transcription export complex|nucleus|nucleoplasmic THO complex
YGL229C	YGL229C	SAP4	hom	Verified	1.16274379036978	0.122466734480523	no	699	0.125024030095149	426	NA	FT	CELL CYCLE	MITOCHONDRION		Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p	G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	mitochondrion|cytoplasm
YNL079C	YNL079C	TPM1	hom	Verified	1.16035313223827	0.122952530154617	no	700	0.130855850766852	528	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication	vacuole inheritance|exocytosis|intracellular mRNA localization|filamentous growth|budding cell apical bud growth|mitochondrion inheritance|budding cell isotropic bud growth|actin polymerization or depolymerization|actin filament organization|pseudohyphal growth|vesicle-mediated transport|establishment of cell polarity|actin filament bundle assembly	actin lateral binding	cellular bud neck contractile ring|actin filament bundle
YNL077W	YNL077W	APJ1	hom	Verified	1.15996183708214	0.123032172101473	no	701	0.157750583590921	566	NA	FT		NUCLEUS|MITOCHONDRION		Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress	biological_process	unfolded protein binding	mitochondrion|nucleus|cytoplasm
YOR313C	YOR313C	SPS4	hom	Verified	1.15954480761238	0.123117091663144	no	702	0.121605066812206	462	NA	FT	CELL CYCLE			Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage	ascospore formation	molecular_function	cellular_component
YFR022W	YFR022W	ROG3	hom	Verified	1.1556088540681	0.123920592383685	no	703	0.100749705018762	378	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; ROG3 has a paralog, ROD1, that arose from the whole genome duplication	ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	cellular_component
YBR268W	YBR268W	MRPL37	hom	Verified	1.15373407778805	0.124304604088137	no	704	0.170261463406967	600	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YCL012C	YCL012C	YCL012C	hom	Verified	1.15319620704236	0.12441493000162	no	705	0.108326428944724	389	NA					Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene	biological_process	molecular_function	cellular_component
YHR021C	YHR021C	RPS27B	hom	Verified	1.15282548039792	0.124491011829932	no	706	0.140349542414011	495	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YGR012W	YGR012W	YGR012W	hom	Verified	1.14882132482239	0.125314832132088	no	707	0.110405611147138	363	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Putative cysteine synthase, localized to the mitochondrial outer membrane	cysteine biosynthetic process	cysteine synthase activity	mitochondrial outer membrane|mitochondrion
YNL329C	YNL329C	PEX6	hom	Verified	1.14776375504486	0.125533051863024	no	708	0.134455073402668	511	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol	protein import into peroxisome matrix, receptor recycling|replicative cell aging	ATPase activity|protein heterodimerization activity	cytosol|peroxisome
YDR368W	YDR368W	YPR1	hom	Verified	1.14758197067773	0.125570588076354	no	709	0.121310183036815	443	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YDR337W	YDR337W	MRPS28	hom	Verified	1.14608759955948	0.125879453983292	no	710	0.153889383968897	536	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome|RNA binding	mitochondrion|mitochondrial small ribosomal subunit
YGL188C-A_p	YGL188C-A	YGL188C-A	hom	Uncharacterized	1.14471640837554	0.126163326069001	no	711	0.145349711765819	563	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDL123W	YDL123W	SNA4	hom	Verified	1.14171240843046	0.126786790667611	no	712	0.141329334709072	406	NA					Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated	biological_process	molecular_function	fungal-type vacuole lumen|fungal-type vacuole membrane
YDR384C	YDR384C	ATO3	hom	Verified	1.14112710800547	0.126908516008348	no	713	0.120213588980311	425	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters	ammonium transport|nitrogen utilization|transmembrane transport	ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YOL008W	YOL008W	COQ10	hom	Verified	1.13939820145715	0.127268552890981	no	714	0.123807781093827	474	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes	cellular respiration	ubiquinone binding	mitochondrion|mitochondrial inner membrane
YDR352W	YDR352W	YPQ2	hom	Verified	1.13725756229443	0.127715314919213	no	715	0.100645299137419	366	NA					Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YGL257C	YGL257C	MNT2	hom	Verified	1.13715374327397	0.127737010146898	no	716	0.126408251232486	417	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans	protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	cellular_component
YHL014C	YHL014C	YLF2	hom	Verified	1.13507040688072	0.128172909824063	no	717	0.126505225421241	432	NA	FT		MITOCHONDRION		Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	GTP binding	mitochondrion
YPR140W	YPR140W	TAZ1	hom	Verified	1.13378639195267	0.12844208024126	no	718	0.124681723157776	404	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome	cardiolipin acyl-chain remodeling|mitochondrial ATP synthesis coupled electron transport|protein complex assembly|inner mitochondrial membrane organization|cardiolipin metabolic process|phospholipid biosynthetic process	1-acylglycerophosphocholine O-acyltransferase activity	mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YDR405W	YDR405W	MRP20	hom	Verified	1.13277745507812	0.128653860659691	no	719	0.12061499788079	468	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGR108W	YGR108W	CLB1	hom	Verified	1.1302882163713	0.129177399102853	no	720	0.114880833087	455	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|meiotic G2/MI transition|regulation of cyclin-dependent protein kinase activity|mitotic spindle organization in nucleus|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YNL297C	YNL297C	MON2	hom	Verified	1.12896205161489	0.129456921222371	no	721	0.15910623991751	479	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins	transport|endocytosis|protein targeting to vacuole|Golgi to endosome transport	guanyl-nucleotide exchange factor activity	cytosol|endosome|trans-Golgi network|extrinsic to membrane
YGR181W	YGR181W	TIM13	hom	Verified	1.12810832950781	0.129637085912225	no	722	0.0945524827820297	379	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane	protein import into mitochondrial inner membrane	protein transporter activity	mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex|mitochondrial intermembrane space
YPL174C	YPL174C	NIP100	hom	Verified	1.12720061382792	0.129828835516037	no	723	0.146904246356413	545	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)	establishment of mitotic spindle orientation	microtubule binding	dynactin complex|cell cortex|spindle pole body|astral microtubule
YGL213C	YGL213C	SKI8	hom	Verified	1.1267295846194	0.129928415024769	no	724	0.116887879347397	438	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE	NUCLEUS|CHROMOSOME		Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay|protein-DNA complex assembly|reciprocal meiotic recombination	molecular_function	Ski complex|nuclear chromosome
YPL054W	YPL054W	LEE1	hom	Verified	1.1259431617673	0.130094789194852	no	725	0.105898936943489	392	NA					Zinc-finger protein of unknown function	biological_process	molecular_function	cellular_component
YBL088C	YBL088C	TEL1	hom	Verified	1.12543566145343	0.130202233269174	no	726	0.125346191096339	448	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)	double-strand break repair|histone phosphorylation|telomere maintenance|response to DNA damage stimulus|phosphorylation|DNA damage induced protein phosphorylation	protein kinase activity|telomeric DNA binding	mitochondrion|nucleus
YHR194W	YHR194W	MDM31	hom	Verified	1.12450897129338	0.130398583388798	no	727	0.151527128562089	509	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	NUCLEUS|MITOCHONDRION		Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34	mitochondrion inheritance|cellular ion homeostasis|mitochondrion organization|Unknown	molecular_function	mitochondrial inner membrane|nucleus
YGL016W	YGL016W	KAP122	hom	Verified	1.12185263439411	0.130962551287626	no	728	0.12843609780318	464	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance	protein import into nucleus|regulation of cell size	protein transporter activity	integral to membrane|nuclear pore|cytoplasm
YDR229W	YDR229W	IVY1	hom	Verified	1.11946805872618	0.131470255080044	no	729	0.137796120662169	513	NA	FT	MEMBRANE ORGANIZATION			Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase	vacuole fusion, non-autophagic	phospholipid binding	fungal-type vacuole membrane
YDR423C	YDR423C	CAD1	hom	Verified	1.118998754357	0.131570335222812	no	730	0.137170352032018	485	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication	cellular response to cadmium ion|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YGL251C	YGL251C	HFM1	hom	Verified	1.11779811788848	0.131826612772719	no	731	0.154705692630756	543	NA	FT	CELL CYCLE	NUCLEUS		Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity	meiosis|synapsis|DNA unwinding involved in replication|reciprocal meiotic recombination	DNA helicase activity	nucleus
YGR196C	YGR196C	FYV8	hom	Verified	1.11611341035776	0.132186796286482	no	732	0.132100411833623	475	NA					Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	cytoplasm
YDR294C	YDR294C	DPL1	hom	Verified	1.11549789520609	0.13231855995204	no	733	0.108212280156335	376	NA	FT	KETONE METABOLISM|LIPID METABOLISM|SIGNALING|RESPONSE TO NUTRIENT LEVELS	ENDOPLASMIC RETICULUM		Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate	calcium-mediated signaling|sphingolipid metabolic process|cellular response to starvation	sphinganine-1-phosphate aldolase activity	endoplasmic reticulum|cortical endoplasmic reticulum|perinuclear endoplasmic reticulum
YDR215C_d	YDR215C	YDR215C	hom	Dubious	1.11437490771885	0.13255919168898	no	734	0.131706381580292	413	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein	Unknown	Unknown	Unknown
YER024W	YER024W	YAT2	hom	Verified	1.11252761059144	0.132955682745667	no	735	0.126687144949059	414	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM			Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane	carnitine metabolic process|alcohol metabolic process	carnitine O-acetyltransferase activity	cytosol|cytoplasm
YDL149W	YDL149W	ATG9	hom	Verified	1.11127490127496	0.133225019701251	no	736	0.108409094261008	333	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|MITOCHONDRION		Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS	piecemeal microautophagy of nucleus|mitochondrion degradation|protein homooligomerization|CVT pathway|autophagic vacuole assembly	molecular_function	mitochondrion|integral to membrane|pre-autophagosomal structure
YGR032W	YGR032W	GSC2	hom	Verified	1.11121607918364	0.133237675881894	no	737	0.110694665103617	399	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE|CYTOSKELETON		Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)	ascospore wall assembly|(1->3)-beta-D-glucan biosynthetic process	1,3-beta-D-glucan synthase activity	1,3-beta-D-glucan synthase complex|integral to membrane|actin cap|prospore membrane
YJL136C	YJL136C	RPS21B	hom	Verified	1.11072510036485	0.133343347319117	no	738	0.140093104001396	460	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YDL009C_p	YDL009C	YDL009C	hom	Uncharacterized	1.10812741687728	0.133903395927463	no	739	0.130709578391845	488	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene	biological_process	molecular_function	cellular_component
YDR247W	YDR247W	VHS1	hom	Verified	1.10797217873206	0.133936915671802	no	740	0.10596998993553	427	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION			Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p	protein phosphorylation|G1/S transition of mitotic cell cycle	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YMR315W	YMR315W	YMR315W	hom	Verified	1.10590067793717	0.134384755671071	no	741	0.138811865833406	494	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress	NADPH regeneration	oxidoreductase activity	nucleus|cytoplasm
YDR108W	YDR108W	TRS85	hom	Verified	1.10582650641485	0.134400809937011	no	742	0.178774816457476	639	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	GOLGI APPARATUS		Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role	meiosis|vesicle organization|piecemeal microautophagy of nucleus|ER to Golgi vesicle-mediated transport|peroxisome degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway	molecular_function	TRAPP complex|pre-autophagosomal structure
YOL018C	YOL018C	TLG2	hom	Verified	1.10384983934638	0.134829140488982	no	743	0.26181046334934	887	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)	inositolphosphoceramide metabolic process|Golgi to vacuole transport|endocytosis|mannosyl-inositol phosphorylceramide metabolic process|protein exit from endoplasmic reticulum|vesicle fusion|CVT pathway	SNAP receptor activity	SNARE complex|trans-Golgi network|integral to endosome membrane
YLL009C	YLL009C	COX17	hom	Verified	1.10156717426245	0.135324942870997	no	744	0.122649824947844	406	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex IV assembly|intracellular copper ion transport	copper chaperone activity	cytosol|mitochondrion|mitochondrial intermembrane space
YOL050C_d	YOL050C	YOL050C	hom	Dubious	1.10120615517475	0.135403471715782	no	745	0.154286374814909	556	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	Unknown	Unknown	Unknown
YDR450W	YDR450W	RPS18A	hom	Verified	1.09847871407523	0.135997753721446	no	746	0.149476939005689	509	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION	MITOCHONDRION	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit|mitochondrion
YPR070W	YPR070W	MED1	hom	Verified	1.09757283766186	0.136195529520129	no	747	0.164939328136807	623	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	molecular_function	core mediator complex
YGL227W	YGL227W	VID30	hom	Verified	1.09730569260209	0.136253891625755	no	748	0.136877901115198	462	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm	regulation of nitrogen utilization|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process	molecular_function	nucleus|GID complex|cytoplasm
YDR418W	YDR418W	RPL12B	hom	Verified	1.09446853348394	0.136874770350089	no	749	0.128682447554177	509	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR261C	YDR261C	EXG2	hom	Verified	1.0931313094388	0.137168075485066	no	750	0.121791664419451	471	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	fungal-type cell wall organization	glucan exo-1,3-beta-glucosidase activity	fungal-type cell wall
YDL202W	YDL202W	MRPL11	hom	Verified	1.09227175695515	0.137356835234308	no	751	0.142139235922695	519	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGR001C_p	YGR001C	YGR001C	hom	Uncharacterized	1.09191195362318	0.137435901534207	no	752	0.109813722090998	374	NA					Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae	biological_process	methyltransferase activity	cytoplasm
YLR203C	YLR203C	MSS51	hom	Verified	1.09078731115894	0.137683240548077	no	753	0.116504544818293	408	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	extrinsic to mitochondrial inner membrane|mitochondrion
YDL194W	YDL194W	SNF3	hom	Verified	1.09078157379121	0.137684503127309	no	754	0.128120109701692	470	NA	FT	CELL CYCLE|SIGNALING	PLASMA MEMBRANE		Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication	mannose transport|glucose transport|signal transduction|negative regulation of meiosis|detection of glucose|fructose transport	glucose transmembrane transporter activity|receptor activity|glucose binding	integral to membrane|plasma membrane
YLR148W	YLR148W	PEP3	hom	Verified	1.08953245281055	0.137959575899737	no	755	0.211295830469867	752	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|vacuole fusion, non-autophagic|late endosome to vacuole transport|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol binding|protein binding, bridging	fungal-type vacuole membrane|HOPS complex|proteasome storage granule|CORVET complex|extrinsic to vacuolar membrane
YIL148W	YIL148W	RPL40A	hom	Verified	1.08829406811186	0.138232654203578	no	756	0.144423120185602	506	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION	NUCLEUS	RIBOSOME	Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	cytoplasmic translation|protein ubiquitination|ribosome biogenesis	structural constituent of ribosome|protein tag	cytosolic large ribosomal subunit
YDR319C_p	YDR319C	YFT2	hom	Uncharacterized	1.08755849329461	0.13839503138878	no	757	0.135975674755329	514	NA					Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens	biological_process	molecular_function	integral to membrane
YMR183C	YMR183C	SSO2	hom	Verified	1.08626969245113	0.138679845818111	no	758	0.123642300987637	488	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p	Golgi to plasma membrane transport|ascospore-type prospore assembly|vesicle fusion	phosphatidic acid binding|SNAP receptor activity	endoplasmic reticulum|plasma membrane|prospore membrane|cytoplasm
YLR453C	YLR453C	RIF2	hom	Verified	1.08331557316985	0.139334187618064	no	759	0.130273972221466	530	NA	FT		NUCLEUS|CHROMOSOME		Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation	telomere capping|telomere maintenance via telomerase	telomeric DNA binding	nuclear telomere cap complex
YGR019W	YGR019W	UGA1	hom	Verified	1.08326702425825	0.139344958789181	no	760	0.125142388898953	456	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress	nitrogen utilization|gamma-aminobutyric acid catabolic process	4-aminobutyrate transaminase activity	intracellular
YGL237C	YGL237C	HAP2	hom	Verified	1.08288718366028	0.139429250636245	no	761	0.12588445805865	469	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex|nucleus
YBR017C	YBR017C	KAP104	hom	Verified	1.08191905157918	0.13964424928524	no	762	0.126424184422136	479	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE	SITE OF POLARIZED GROWTH		Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis	protein import into nucleus|cell cycle|mRNA-binding (hnRNP) protein import into nucleus|transcription factor import into nucleus	nuclear localization sequence binding	cytosol|integral to membrane|cellular bud neck|cellular bud tip
YDR070C	YDR070C	FMP16	hom	Verified	1.08143423923517	0.13975199901084	no	763	0.12311622236783	468	NA	FT		MITOCHONDRION		Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrion
YDR305C	YDR305C	HNT2	hom	Verified	1.07985282081972	0.140103862652671	no	764	0.121072163599463	413	NA	FT		NUCLEUS|MITOCHONDRION		Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins	nucleoside catabolic process	hydrolase activity|nucleoside-triphosphatase activity	mitochondrion|nucleus|cytoplasm
YNL080C	YNL080C	EOS1	hom	Verified	1.07903108500308	0.140286935282616	no	765	0.158193012621951	532	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene	cellular response to oxidative stress|protein N-linked glycosylation	molecular_function	integral to membrane|endoplasmic reticulum membrane
YEL038W	YEL038W	UTR4	hom	Verified	1.07721025806314	0.140693171756288	no	766	0.100797353524295	389	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus	L-methionine salvage from methylthioadenosine	acireductone synthase activity	nucleus|cytoplasm
YER085C_p	YER085C	YER085C	hom	Uncharacterized	1.07705680577457	0.140727444241065	no	767	0.116634644727916	425	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR092W	YOR092W	ECM3	hom	Verified	1.07398923644975	0.141413752867896	no	768	0.133241561513744	410	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication	fungal-type cell wall organization	ATPase activity	integral to membrane|endoplasmic reticulum
YDR061W_p	YDR061W	YDR061W	hom	Uncharacterized	1.07305387207585	0.141623472880267	no	769	0.146095012538833	478	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance	biological_process	molecular_function	mitochondrion
YER007W	YER007W	PAC2	hom	Verified	1.0725716317835	0.141731679266763	no	770	0.141964543112727	523	NA	FT		CYTOSKELETON		Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl	protein folding|tubulin complex assembly|tubulin complex biogenesis	alpha-tubulin binding	cellular_component
YDR163W	YDR163W	CWC15	hom	Verified	1.06751511437799	0.142869646108179	no	771	0.135453392638383	491	NA	FT	RNA PROCESSING	NUCLEUS		Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YGL088W_d	YGL088W	YGL088W	hom	Dubious	1.06553798752502	0.143316272321387	no	772	0.146289711505986	504	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing	Unknown	Unknown	Unknown
YBR196C-B_p	YBR196C-B	YBR196C-B	hom	Uncharacterized	1.06542237761849	0.14334241735116	no	773	0.130653991803622	480	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YDL187C_d	YDL187C	YDL187C	hom	Dubious	1.0652589955319	0.143379371488962	no	774	0.165131910858917	525	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL219C	YGL219C	MDM34	hom	Verified	1.06249721227061	0.144005011446507	no	775	0.182242374025185	617	NA	FT	MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth	mitochondrion organization|phospholipid transport	molecular_function	mitochondrial outer membrane|ERMES complex|mitochondrion|cytoplasm
YOR061W	YOR061W	CKA2	hom	Verified	1.06228320487114	0.144053568311286	no	776	0.166106972522204	643	NA	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching	regulation of transcription from RNA polymerase I promoter|chronological cell aging|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase activity	protein kinase CK2 complex|UTP-C complex
YDL124W	YDL124W	YDL124W	hom	Verified	1.06128767227026	0.144279593214517	no	777	0.114393120188192	433	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress|cellular ketone metabolic process|cellular amide metabolic process|cellular aromatic compound metabolic process	alpha-keto amide reductase activity|aldo-keto reductase (NADP) activity|alditol:NADP+ 1-oxidoreductase activity|alpha-keto ester reductase activity	nucleus|plasma membrane|cytoplasm
YOR047C	YOR047C	STD1	hom	Verified	1.05621753605251	0.145434420437843	no	778	0.147952153405267	505	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM	NUCLEUS|PLASMA MEMBRANE		Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]	response to salt stress|signal transduction|nicotinamide riboside biosynthetic process|glucose metabolic process|nicotinic acid riboside biosynthetic process|regulation of transcription from RNA polymerase II promoter	protein kinase activator activity	plasma membrane|nucleus
YOR078W	YOR078W	BUD21	hom	Verified	1.05585743836724	0.145516675852802	no	779	0.141057267381786	488	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|90S preribosome
YBR020W	YBR020W	GAL1	hom	Verified	1.05375921545887	0.145996585194948	no	780	0.138070946426847	512	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS			Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication	galactose catabolic process via UDP-galactose|carbohydrate phosphorylation|positive regulation of transcription by galactose	galactokinase activity	cytoplasm
YGL039W	YGL039W	YGL039W	hom	Verified	1.05356592032098	0.146040849442412	no	781	0.117896135058707	392	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS			Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols	cellular ketone metabolic process|cellular aromatic compound metabolic process	oxidoreductase activity, acting on CH-OH group of donors|carbonyl reductase (NADPH) activity	cytoplasm
YEL005C	YEL005C	VAB2	hom	Verified	1.0534628726498	0.146064450862494	no	782	0.143826598418334	502	NA					Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter	biological_process	molecular_function	cytoplasm
YOR123C	YOR123C	LEO1	hom	Verified	1.05264142638638	0.146252681607565	no	783	0.146446826771126	560	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	RNA POL II, HOLOENZYME	Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	chromatin organization|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription-coupled nucleotide-excision repair|histone H3-K4 trimethylation|transcription elongation from RNA polymerase II promoter	RNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|Cdc73/Paf1 complex
YOR334W	YOR334W	MRS2	hom	Verified	1.04843164242584	0.147219890649504	no	784	0.133973920637987	481	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns	mitochondrial magnesium ion transport	magnesium ion transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YGR051C_d	YGR051C	YGR051C	hom	Dubious	1.04838709498261	0.147230148416002	no	785	0.133783298264512	505	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene	Unknown	Unknown	Unknown
YLR046C_p	YLR046C	YLR046C	hom	Uncharacterized	1.04668599028678	0.147622213640327	no	786	0.135302795294322	461	NA					Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	biological_process	molecular_function	integral to membrane
YGL186C	YGL186C	TPN1	hom	Verified	1.04648915894951	0.147667623801632	no	787	0.274821671611756	970	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p	vitamin transport	vitamin transporter activity	integral to membrane|plasma membrane
YGL104C	YGL104C	VPS73	hom	Verified	1.04648771821804	0.147667956221446	no	788	0.164222667122704	561	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	MITOCHONDRION		Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family	transport|transmembrane transport|protein targeting to vacuole	substrate-specific transmembrane transporter activity	mitochondrion|integral to membrane
YHR067W	YHR067W	HTD2	hom	Verified	1.04578681459826	0.147829735069418	no	789	0.181586446604146	656	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology	fatty acid biosynthetic process	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	mitochondrion
YDL177C_p	YDL177C	YDL177C	hom	Uncharacterized	1.04372162240957	0.148307101486112	no	790	0.123346654302313	474	NA					Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene	biological_process	molecular_function	cellular_component
YOL031C	YOL031C	SIL1	hom	Verified	1.04318541046463	0.148431214598931	no	791	0.135699912965905	533	NA	FT	PROTEIN LOCALIZATION	ENDOPLASMIC RETICULUM		Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein	SRP-dependent cotranslational protein targeting to membrane, translocation	adenyl-nucleotide exchange factor activity	endoplasmic reticulum
YCR077C	YCR077C	PAT1	hom	Verified	1.041191829648	0.148893263451622	no	792	0.166072663196213	620	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|TRANSLATION|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS	RIBOSOME	Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|chromosome segregation|regulation of translational initiation|formation of translation preinitiation complex|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly	molecular_function	cytosolic small ribosomal subunit|cytoplasmic mRNA processing body
YOL009C	YOL009C	MDM12	hom	Verified	1.04077104109174	0.148990911606206	no	793	0.146441981776804	556	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins	mitochondrion inheritance|mitochondrion organization|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrion|ERMES complex
YBR098W	YBR098W	MMS4	hom	Verified	1.04008261120122	0.149150760820753	no	794	0.137706738917874	503	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	transcription coactivator activity|endonuclease activity|crossover junction endodeoxyribonuclease activity	Holliday junction resolvase complex|nucleus
YGR197C	YGR197C	SNG1	hom	Verified	1.03887483090052	0.14943147667352	no	795	0.132658402085915	461	NA	FT		PLASMA MEMBRANE		Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance	nucleobase-containing compound transport	molecular_function	integral to membrane|plasma membrane
YMR223W	YMR223W	UBP8	hom	Verified	1.03838445509028	0.149545551859453	no	796	0.130649232628534	505	NA	FT	CHROMATIN ORGANIZATION|PROTEOLYSIS	NUCLEUS	HISTONE ACETYLTRANSFERASE	Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B	histone H3-K4 methylation|histone deubiquitination|histone H3-K79 methylation	ubiquitin-specific protease activity|protein complex scaffold	DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YCL005W	YCL005W	LDB16	hom	Verified	1.03788275235089	0.149662322137557	no	797	0.178627321804071	633	NA	FT		MITOCHONDRION		Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria	biological_process	molecular_function	mitochondrion|lipid particle
YNL107W	YNL107W	YAF9	hom	Verified	1.03773973261925	0.149695620825115	no	798	0.18277502863754	658	NA	FF|FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain	DNA repair|chromatin remodeling|histone exchange|chromatin silencing at telomere	molecular_function	Swr1 complex|nucleus|NuA4 histone acetyltransferase complex|cytoplasm
YGL087C	YGL087C	MMS2	hom	Verified	1.03488646673409	0.150360967761464	no	799	0.142083713561275	479	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress	postreplication repair|response to DNA damage stimulus|protein polyubiquitination|free ubiquitin chain polymerization	ubiquitin-protein ligase activity	ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YBR298C	YBR298C	MAL31	hom	Verified	1.03385055530721	0.150603016543741	no	800	0.175574066142762	632	NA	FT	CARBOHYDRATE METABOLISM			Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C	alpha-glucoside transport|transmembrane transport	alpha-glucoside:hydrogen symporter activity	integral to membrane|membrane
YPL150W_p	YPL150W	YPL150W	hom	Uncharacterized	1.03240168290567	0.150941991951909	no	801	0.118180814413482	442	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study	protein phosphorylation	protein kinase activity	cellular_component
YBR134W_d	YBR134W	YBR134W	hom	Dubious	1.02818847128479	0.15193059020173	no	802	0.142232566418538	567	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL122W	YDL122W	UBP1	hom	Verified	1.02758290602486	0.152073034254284	no	803	0.143992862279664	540	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains	protein deubiquitination	ubiquitin-specific protease activity	endoplasmic reticulum|cytoplasm
YGL178W	YGL178W	MPT5	hom	Verified	1.02721726958702	0.152159083993957	no	804	0.127645583650245	465	NA	FT	TRANSLATION			mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity	negative regulation of translation|negative regulation of translational initiation|Unknown	mRNA binding|protein binding, bridging	cytoplasm
YOR200W_d	YOR200W	YOR200W	hom	Dubious	1.02683236095863	0.15224970422228	no	805	0.204656287700318	726	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c	Unknown	Unknown	Unknown
YHR051W	YHR051W	COX6	hom	Verified	1.02557913167983	0.152545004070695	no	806	0.147248430671331	569	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YOL051W	YOL051W	GAL11	hom	Verified	1.02474833896178	0.152740974044599	no	807	0.224306846242112	792	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|TFIIE-class binding transcription factor activity|RNA polymerase II activating transcription factor binding|TFIIE-class transcription factor binding|TFIIH-class transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity	core mediator complex
YBL090W	YBL090W	MRP21	hom	Verified	1.02456369791297	0.152784550419891	no	808	0.183429444347929	630	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences	mitochondrial translational initiation|mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YBL069W	YBL069W	AST1	hom	Verified	1.02429201814265	0.152848683436211	no	809	0.134409415954317	507	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS	GOLGI APPARATUS|PLASMA MEMBRANE		Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication	protein targeting to membrane|protein transport into membrane raft	molecular_function	late endosome|membrane raft|Golgi apparatus|plasma membrane
YPL112C	YPL112C	PEX25	hom	Verified	1.01406142225881	0.155276722274526	no	810	0.153783790346668	549	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p	protein import into peroxisome matrix|peroxisome organization	molecular_function	peroxisomal membrane
YDR277C	YDR277C	MTH1	hom	Verified	1.01338017913474	0.155439301559329	no	811	0.146394976432121	452	NA	FT	SIGNALING			Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation	glucose transport|signal transduction	molecular_function	cellular_component
YBL010C_p	YBL010C	YBL010C	hom	Uncharacterized	1.01248803709769	0.155652381854697	no	812	0.153056953653028	555	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles	biological_process	molecular_function	clathrin-coated vesicle
YLR393W	YLR393W	ATP10	hom	Verified	1.00928220888759	0.156419654998822	no	813	0.152536539115715	508	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6	mitochondrial proton-transporting ATP synthase complex assembly	unfolded protein binding	integral to mitochondrial membrane|mitochondrion|mitochondrial inner membrane
YIL029C_p	YIL029C	YIL029C	hom	Uncharacterized	1.00851949515425	0.156602566745486	no	814	0.174353500589643	626	NA					Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W	biological_process	molecular_function	integral to membrane
YDR183W	YDR183W	PLP1	hom	Verified	1.00818026687408	0.156683964688223	no	815	0.142883458987303	470	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING			Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators	protein folding|positive regulation of transcription from RNA polymerase II promoter by pheromones	G-protein beta/gamma-subunit complex binding	cellular_component
YNL284C	YNL284C	MRPL10	hom	Verified	1.0080098687175	0.156724862290207	no	816	0.16637905057662	595	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOR306C	YOR306C	MCH5	hom	Verified	1.00644171397639	0.15710156806852	no	817	0.135701794791044	450	NA	FT		PLASMA MEMBRANE		Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport	riboflavin transport	monocarboxylic acid transmembrane transporter activity|riboflavin transporter activity	integral to membrane|plasma membrane
YAL049C	YAL049C	AIM2	hom	Verified	1.00324122576071	0.157872243200683	no	818	0.14686275497053	539	NA					Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor	biological_process	molecular_function	cytoplasm
YMR150C	YMR150C	IMP1	hom	Verified	1.00216878287896	0.158131041035534	no	819	0.141793041653011	437	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	protein processing involved in protein targeting to mitochondrion	endopeptidase activity	mitochondrion|mitochondrial inner membrane peptidase complex
YDL104C	YDL104C	QRI7	hom	Verified	1.00175871612139	0.158230070334841	no	820	0.160595439972509	525	NA	FT	RNA PROCESSING|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification	mitochondrial tRNA threonylcarbamoyladenosine modification	molecular_function	mitochondrion
YHR014W	YHR014W	SPO13	hom	Verified	1.00145325011313	0.158303865461914	no	821	0.124265288870087	451	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II	protein localization to chromosome, centromeric region|meiotic sister chromatid cohesion|positive regulation of sister chromatid cohesion	molecular_function	nucleus|condensed nuclear chromosome, centromeric region
YGL200C	YGL200C	EMP24	hom	Verified	1.00039452222156	0.15855980993477	no	822	0.163773632023738	602	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles	protein retention in ER lumen|vesicle organization|ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum|ER to Golgi transport vesicle
YNL338W_d	YNL338W	YNL338W	hom	Dubious	1.00007474400761	0.158637168745686	no	823	0.14230598677374	531	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV	Unknown	Unknown	Unknown
YDL167C	YDL167C	NRP1	hom	Verified	0.998979180736541	0.158902388383672	no	824	0.169909716886998	548	NA					Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	cytoplasmic stress granule|cytoplasm
YOL150C_d	YOL150C	YOL150C	hom	Dubious	0.997210139672089	0.159331260122955	no	825	0.14667732275169	498	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR213W	YDR213W	UPC2	hom	Verified	0.997187978046234	0.159336637607528	no	826	0.168485753934069	610	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication	cellular response to hypoxia|positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|membrane|cytoplasm|perinuclear region of cytoplasm
YDL110C	YDL110C	TMA17	hom	Verified	0.996655628735954	0.159465847066152	no	827	0.138586401529856	487	NA	FT		NUCLEUS		Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YDL099W	YDL099W	BUG1	hom	Verified	0.996610570988426	0.159476786429981	no	828	0.124168250594159	457	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	GOLGI APPARATUS		Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes	protein secretion|ER to Golgi vesicle-mediated transport	molecular_function	cis-Golgi network|cytoplasm
YDL142C	YDL142C	CRD1	hom	Verified	0.996346644738589	0.159540873739586	no	829	0.152630431854816	500	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis	lipid biosynthetic process|cellular ion homeostasis|mitochondrial membrane organization	cardiolipin synthase activity	mitochondrion|integral to membrane
YNL209W	YNL209W	SSB2	hom	Verified	0.995606475301778	0.159720693665978	no	830	0.101074215549871	359	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS			Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication	cellular response to glucose starvation|cytoplasmic translation|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity|'de novo' cotranslational protein folding	unfolded protein binding|ATPase activity	plasma membrane|polysome|cytoplasm
YDR085C	YDR085C	AFR1	hom	Verified	0.992091122518045	0.160576538342791	no	831	0.154403139242475	556	NA	FT	SIGNALING			Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication	regulation of G-protein coupled receptor protein signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation	receptor signaling protein activity	mating projection base
YMR039C	YMR039C	SUB1	hom	Verified	0.991710187545943	0.160669459995642	no	832	0.147959636105328	487	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress	termination of RNA polymerase II transcription|hyperosmotic response|RNA polymerase III transcriptional preinitiation complex assembly|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase III promoter	transcription coactivator activity	nucleus
YDR508C	YDR508C	GNP1	hom	Verified	0.990969126095707	0.160850328063652	no	833	0.132572162276552	482	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity|L-proline transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YNL056W	YNL056W	OCA2	hom	Verified	0.990892414841134	0.160869058278804	no	834	0.158968550452052	532	NA					Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene	biological_process	molecular_function	cytoplasm
YOR376W-A_p	YOR376W-A	YOR376W-A	hom	Uncharacterized	0.989772029722434	0.161142779533985	no	835	0.140958836619597	477	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YOR349W	YOR349W	CIN1	hom	Verified	0.989681806793251	0.161164835108424	no	836	0.162211657684194	659	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS			Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl	protein folding|tubulin complex assembly|tubulin complex biogenesis	beta-tubulin binding	cellular_component
YDR274C_d	YDR274C	YDR274C	hom	Dubious	0.989484218790294	0.161213143644087	no	837	0.135011654251106	467	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL022C_p	YNL022C	YNL022C	hom	Uncharacterized	0.989406259881198	0.161232206513008	no	838	0.146062173203669	542	NA	FT		NUCLEUS		Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis	biological_process	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YFL013W-A_d	YFL013W-A	YFL013W-A	hom	Dubious	0.986909149046247	0.161843589334936	no	839	0.179853333264042	638	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching	Unknown	Unknown	Unknown
YNL271C	YNL271C	BNI1	hom	Verified	0.986288039893798	0.161995893545859	no	840	0.214760180420632	765	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1	barbed-end actin filament capping|actin nucleation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly|establishment of mitotic spindle orientation|formin-nucleated actin cable assembly	profilin binding	incipient cellular bud site|actin filament|polarisome|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YDR092W	YDR092W	UBC13	hom	Verified	0.985641550333166	0.162154520497314	no	841	0.146725130013216	535	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus	postreplication repair|protein monoubiquitination|protein polyubiquitination|free ubiquitin chain polymerization	ubiquitin-protein ligase activity	ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YLR185W	YLR185W	RPL37A	hom	Verified	0.98503355488818	0.162303794537145	no	842	0.154222512986555	516	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR266C	YLR266C	PDR8	hom	Verified	0.98485483406267	0.162347690786835	no	843	0.1482466223516	529	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YCR081W	YCR081W	SRB8	hom	Verified	0.984424354520104	0.162453454100104	no	844	0.179382799434398	646	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity	mediator complex
YGL180W	YGL180W	ATG1	hom	Verified	0.982744692553968	0.162866554245769	no	845	0.153749714787768	518	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p	piecemeal microautophagy of nucleus|mitochondrion degradation|protein phosphorylation|CVT pathway|autophagic vacuole assembly	protein serine/threonine kinase activity|protein kinase activity	cytosol|pre-autophagosomal structure|Atg1p signaling complex
YGR107W_d	YGR107W	YGR107W	hom	Dubious	0.982417740525058	0.162947044974169	no	846	0.166143609158495	602	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER066W_p	YER066W	RRT13	hom	Uncharacterized	0.981064333768277	0.163280508652296	no	847	0.127294896737346	484	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription	biological_process	molecular_function	cellular_component
YNL298W	YNL298W	CLA4	hom	Verified	0.9782513439262	0.163975014033397	no	848	0.232174444750895	787	NA	FF|FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p	negative regulation of gene expression|vacuole inheritance|protein phosphorylation|budding cell apical bud growth|Rho protein signal transduction|regulation of exit from mitosis|establishment of cell polarity|sterol import|response to pheromone|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	nucleus|cellular bud|fungal-type vacuole
YOR371C	YOR371C	GPB1	hom	Verified	0.977994688543245	0.164038475532707	no	849	0.155030006982292	550	NA	FT	SIGNALING|PROTEOLYSIS	PLASMA MEMBRANE		Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication	positive regulation of Ras protein signal transduction|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of phosphorylation|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|invasive growth in response to glucose limitation|negative regulation of Ras protein signal transduction|protein polyubiquitination	cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding	plasma membrane|cytoplasm
YCL037C	YCL037C	SRO9	hom	Verified	0.9774701238003	0.164168230784169	no	850	0.200520751243499	703	NA	FT	TRANSLATION			Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication	cytoplasmic translation	RNA binding	polysome
YDR389W	YDR389W	SAC7	hom	Verified	0.97730701887412	0.164208589644991	no	851	0.233776106235413	810	NA	FF|FT	CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION	CYTOSKELETON		GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate	actin filament reorganization involved in cell cycle|small GTPase mediated signal transduction	Rho GTPase activator activity	intracellular
YGL121C	YGL121C	GPG1	hom	Verified	0.97631632023676	0.164453867417725	no	852	0.137117956592949	507	NA	FT	SIGNALING			Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing	signal transduction|invasive growth in response to glucose limitation	signal transducer activity	cellular_component
YBR206W_d	YBR206W	YBR206W	hom	Dubious	0.976023197972261	0.164526484310258	no	853	0.177332584170487	596	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3	Unknown	Unknown	Unknown
YDR206W	YDR206W	EBS1	hom	Verified	0.974833478200883	0.164821433857289	no	854	0.171534438702583	504	NA	FT	TRANSLATION	NUCLEUS|CHROMOSOME		Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors	negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YGR163W	YGR163W	GTR2	hom	Verified	0.973944603907449	0.165042022646671	no	855	0.212437904724952	755	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION	NUCLEUS|CHROMOSOME		Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD	microautophagy|positive regulation of transcription from RNA polymerase II promoter	GTP binding	nuclear chromatin|fungal-type vacuole membrane|integral to membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YLL010C	YLL010C	PSR1	hom	Verified	0.973767277427189	0.165086051990856	no	856	0.174992116165029	622	NA	FT		PLASMA MEMBRANE		Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p	response to stress	phosphoprotein phosphatase activity	plasma membrane
YCR047C	YCR047C	BUD23	hom	Verified	0.973488023669339	0.165155404821344	no	857	0.155779275622733	554	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION	NUCLEUS		Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA (guanine-N7)-methylation|cellular bud site selection|ribosomal small subunit export from nucleus	S-adenosylmethionine-dependent methyltransferase activity|rRNA (guanine) methyltransferase activity	nucleolus|nucleus|cytoplasm
YGR020C	YGR020C	VMA7	hom	Verified	0.973353057049656	0.16518893061756	no	858	0.217986555328643	773	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YHR082C	YHR082C	KSP1	hom	Verified	0.971025051234698	0.165767901960677	no	859	0.170196764927622	590	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress	TOR signaling cascade|protein phosphorylation|Unknown|cellular protein localization|regulation of filamentous growth|negative regulation of macroautophagy	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YPL060W	YPL060W	MFM1	hom	Verified	0.970175677686515	0.165979466056674	no	860	0.199071848089438	676	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p	mitochondrial magnesium ion transport	magnesium ion transmembrane transporter activity	integral to membrane|mitochondrial inner membrane
YHR034C	YHR034C	PIH1	hom	Verified	0.967979867116326	0.166527212304171	no	861	0.189493147417921	637	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II	protein folding|rRNA processing|regulation of cell size|box C/D snoRNP assembly	molecular_function	R2TP complex|nucleus|small nucleolar ribonucleoprotein complex|cytoplasm
YIL018W	YIL018W	RPL2B	hom	Verified	0.967936561312035	0.166538026682645	no	862	0.15078076111072	513	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YFL063W_d	YFL063W	YFL063W	hom	Dubious	0.966875096908927	0.166803238598995	no	863	0.123967938708066	426	NA					Dubious open reading frame, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR291W	YDR291W	HRQ1	hom	Verified	0.966825767405435	0.166815570431624	no	864	0.155221311059491	533	NA	FT		NUCLEUS		3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)	biological_process	molecular_function	nucleus
YDR165W	YDR165W	TRM82	hom	Verified	0.965330705418119	0.167189598494566	no	865	0.188062213009866	591	NA	FT	RNA PROCESSING	NUCLEUS		Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p	tRNA methylation	tRNA (guanine-N7-)-methyltransferase activity	tRNA methyltransferase complex|nucleus
YCR095W-A_p	YCR095W-A	YCR095W-A	hom	Uncharacterized	0.964913374701856	0.167294100909675	no	866	0.159257617084844	551	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YEL071W	YEL071W	DLD3	hom	Verified	0.964602076543531	0.167372079467818	no	867	0.16057279843467	519	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS			D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm	lactate metabolic process|filamentous growth	D-lactate dehydrogenase (cytochrome) activity	cytoplasm
YDL242W_d	YDL242W	YDL242W	hom	Dubious	0.96457640116326	0.16737851206153	no	868	0.144120358823555	498	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR298C	YDR298C	ATP5	hom	Verified	0.964197494820484	0.167473460067054	no	869	0.181669415204504	625	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, stator stalk|mitochondrial proton-transporting ATP synthase complex
YDR034C	YDR034C	LYS14	hom	Verified	0.963832286489315	0.167565008401012	no	870	0.169894259867975	554	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YGR022C_d	YGR022C	YGR022C	hom	Dubious	0.963715379210579	0.167594320858546	no	871	0.132201271773327	453	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W	Unknown	Unknown	Unknown
YJL046W	YJL046W	AIM22	hom	Verified	0.961831980765646	0.168067005281524	no	872	0.166526858644314	564	NA	FT		MITOCHONDRION		Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss	protein lipoylation	lipoate-protein ligase activity	mitochondrion
YMR021C	YMR021C	MAC1	hom	Verified	0.959397252704664	0.168679329295365	no	873	0.28291678229507	1011	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS		Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport	cellular copper ion homeostasis|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter	core promoter proximal region DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YBR195C	YBR195C	MSI1	hom	Verified	0.956797227627105	0.169334805926454	no	874	0.153377733616836	511	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase	DNA replication-dependent nucleosome assembly	histone binding	nucleus|CAF-1 complex|cytoplasm
YLR360W	YLR360W	VPS38	hom	Verified	0.956729255286338	0.169351963923855	no	875	0.156274824704857	513	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated	ER-associated protein catabolic process|late endosome to vacuole transport	molecular_function	phosphatidylinositol 3-kinase complex II
YDR428C	YDR428C	BNA7	hom	Verified	0.953941422097468	0.170056647287331	no	876	0.146811385841829	502	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine	NAD biosynthetic process	arylformamidase activity	cellular_component
YNR028W	YNR028W	CPR8	hom	Verified	0.953185930810106	0.170247936765169	no	877	0.150376551116391	499	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	fungal-type vacuole
YDR279W	YDR279W	RNH202	hom	Verified	0.953184864836261	0.170248206765811	no	878	0.148838396962684	527	NA	FT		NUCLEUS		Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome	RNA catabolic process|DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus
YFL055W	YFL055W	AGP3	hom	Verified	0.95294154977821	0.170309843243574	no	879	0.156219414668156	526	NA	FT		PLASMA MEMBRANE		Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YPL029W	YPL029W	SUV3	hom	Verified	0.952093917811018	0.170524676674516	no	880	0.232123581847428	782	NA	FF|FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION|CHROMOSOME		ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron	mitochondrial DNA replication|mitochondrial RNA catabolic process|Group I intron splicing	exoribonuclease II activity|ATP-dependent RNA helicase activity	mitochondrion|mitochondrial chromosome|mitochondrial degradosome
YGR133W	YGR133W	PEX4	hom	Verified	0.952048809879198	0.170536114199657	no	881	0.149233701763866	501	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis	peroxisome organization|protein import into peroxisome matrix, receptor recycling|protein autoubiquitination|protein monoubiquitination|protein polyubiquitination	ubiquitin-protein ligase activity	peroxisome
YNL081C	YNL081C	SWS2	hom	Verified	0.951920570447639	0.170568633153589	no	882	0.219488247331504	758	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency	regulation of sporulation resulting in formation of a cellular spore|mitochondrial translation	structural constituent of ribosome	mitochondrial small ribosomal subunit|cytoplasm
YLR019W	YLR019W	PSR2	hom	Verified	0.951751996952061	0.170611386058381	no	883	0.169153680033461	565	NA	FT		PLASMA MEMBRANE		Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p	response to stress	phosphoprotein phosphatase activity	plasma membrane
YOL072W	YOL072W	THP1	hom	Verified	0.948526108730533	0.171430843876049	no	884	0.231108303571149	792	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding	mRNA export from nucleus|mRNA 3'-end processing|transcription-coupled nucleotide-excision repair|cellular bud site selection|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|transcription elongation from RNA polymerase II promoter	double-stranded DNA binding|RNA binding	nuclear envelope|nucleus|transcription export complex 2|nuclear pore
YGL211W	YGL211W	NCS6	hom	Verified	0.948056409629202	0.171550368880231	no	885	0.176426781397694	623	NA	FT	RNA PROCESSING	MITOCHONDRION		Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	tRNA wobble position uridine thiolation|protein urmylation|tRNA wobble uridine modification	tRNA binding	cytosol|mitochondrion
YJR152W	YJR152W	DAL5	hom	Verified	0.9480128121949	0.17156146588196	no	886	0.167239061865698	526	NA	FT		PLASMA MEMBRANE		Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression	dipeptide transport|allantoate transport	dipeptide transporter activity|allantoate transmembrane transporter activity	integral to membrane|plasma membrane
YGL164C	YGL164C	YRB30	hom	Verified	0.946804779554985	0.171869132917646	no	887	0.168289910648903	584	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes	biological_process	GTPase regulator activity	nucleus|cytoplasm
YDR254W	YDR254W	CHL4	hom	Verified	0.943564504989396	0.172696118915657	no	888	0.169455893744641	558	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15	kinetochore assembly|chromosome segregation|establishment of meiotic sister chromatid cohesion|protein localization to chromosome, centromeric region|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	structural molecule activity	condensed nuclear chromosome outer kinetochore
YOR289W_p	YOR289W	YOR289W	hom	Uncharacterized	0.942205592180965	0.173043695700545	no	889	0.156092283440384	522	NA	FT		NUCLEUS		Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YGR031W	YGR031W	IMO32	hom	Verified	0.94137538980947	0.173256260374745	no	890	0.158075892488136	567	NA	FT		MITOCHONDRION		Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1	biological_process	molecular_function	mitochondrion
YEL072W	YEL072W	RMD6	hom	Verified	0.937550457165323	0.174237740966692	no	891	0.173224954567192	602	NA	FT	CELL CYCLE			Protein required for sporulation	biological_process	molecular_function	cellular_component
YDR436W	YDR436W	PPZ2	hom	Verified	0.9367612516944	0.174440690556524	no	892	0.167202117785154	562	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular sodium ion homeostasis	protein serine/threonine phosphatase activity	cellular_component
YGL094C	YGL094C	PAN2	hom	Verified	0.935783075205859	0.174692443643159	no	893	0.18736164420581	633	NA	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEOLYSIS			Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes	mRNA 3'-end processing|postreplication repair|mRNA processing	poly(A)-specific ribonuclease activity	PAN complex|cytoplasm
YOR005C	YOR005C	DNL4	hom	Verified	0.935259590772541	0.174827267434592	no	894	0.155440420610008	530	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	NUCLEUS|CHROMOSOME		DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth	double-strand break repair via nonhomologous end joining|replicative cell aging	DNA ligase (ATP) activity	DNA ligase IV complex|nuclear chromatin
YDR090C_p	YDR090C	YDR090C	hom	Uncharacterized	0.930923379648406	0.175946599860743	no	895	0.195974693075049	674	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YDR143C	YDR143C	SAN1	hom	Verified	0.929802431874951	0.176236693488233	no	896	0.174936079627251	548	NA	FT	PROTEOLYSIS	NUCLEUS		Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition	nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to misfolded protein|response to stress	ubiquitin-protein ligase activity	nucleus|cytoplasm
YJR060W	YJR060W	CBF1	hom	Verified	0.9288978100685	0.176471024009177	no	897	0.204282238287462	712	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME	KINETOCHORE	Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress	regulation of transcription from RNA polymerase II promoter in response to methionine|negative regulation of transcription from RNA polymerase II promoter|methionine biosynthetic process|chromosome segregation|Unknown|chromatin remodeling|negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II repressing transcription factor binding|centromeric DNA binding	chromosome, centromeric region|mitochondrion|nucleus|kinetochore
YLR454W_p	YLR454W	FMP27	hom	Uncharacterized	0.928744237476225	0.176510824553499	no	898	0.166458058913434	609	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YJR115W_p	YJR115W	YJR115W	hom	Uncharacterized	0.928676526529605	0.176528374621768	no	899	0.156292880041584	527	NA					Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YGR132C	YGR132C	PHB1	hom	Verified	0.928593282891332	0.176549952136383	no	900	0.154419026325001	516	NA	FT	MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation	mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging|mitochondrion morphogenesis|inner mitochondrial membrane organization	molecular_function	mitochondrion|mitochondrial inner membrane
YGL177W_d	YGL177W	YGL177W	hom	Dubious	0.927690757888445	0.176784001968614	no	901	0.209271138241408	712	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL178W	YDL178W	DLD2	hom	Verified	0.927544669276366	0.176821905243807	no	902	0.21982489397083	738	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		D-lactate dehydrogenase, located in the mitochondrial matrix	lactate metabolic process	actin binding|D-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial matrix
YDR010C_d	YDR010C	YDR010C	hom	Dubious	0.926994388932422	0.176964723793295	no	903	0.200613713315177	646	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR123C_d	YPR123C	YPR123C	hom	Dubious	0.925743174465327	0.1772897324539	no	904	0.29604538792543	1011	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR	Unknown	Unknown	Unknown
YLR261C_d	YLR261C	VPS63	hom	Dubious	0.925564615507501	0.177336144671856	no	905	0.280770664639578	945	NA	FF				Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YPL165C	YPL165C	SET6	hom	Verified	0.92494217269339	0.177497994076523	no	906	0.15715515328337	517	NA					SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability	biological_process	molecular_function	cellular_component
YOR141C	YOR141C	ARP8	hom	Verified	0.923395367688154	0.177900602441325	no	907	0.182780587762989	698	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME|CYTOSKELETON		Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity	mitotic recombination|response to DNA damage stimulus|chromatin remodeling	mRNA binding|ATP-dependent 3'-5' DNA helicase activity	nucleus|Ino80 complex
YDR512C	YDR512C	EMI1	hom	Verified	0.923060776988749	0.177987766704534	no	908	0.175247905982281	616	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|MITOCHONDRION ORGANIZATION			Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs	ascospore formation|mitochondrial respiratory chain complex assembly|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YLR062C_d	YLR062C	BUD28	hom	Dubious	0.919753784000126	0.178850719768487	no	909	0.200491479627001	652	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YDL068W_d	YDL068W	YDL068W	hom	Dubious	0.919688446476354	0.178867795948483	no	910	0.204659482010435	717	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR293C	YMR293C	HER2	hom	Verified	0.917930816116473	0.179327543561644	no	911	0.193486785094525	689	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase	endoplasmic reticulum organization|glutaminyl-tRNAGln biosynthesis via transamidation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YGL192W	YGL192W	IME4	hom	Verified	0.917504860104776	0.179439073664186	no	912	0.204311516813286	691	NA	FT	CELL CYCLE	NUCLEUS		Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids	meiosis|mRNA methylation	mRNA (N6-adenosine)-methyltransferase activity	cellular_component
YJL180C	YJL180C	ATP12	hom	Verified	0.917216155284193	0.179514691418406	no	913	0.183548708335453	663	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency	mitochondrial proton-transporting ATP synthase complex assembly	protein domain specific binding	mitochondrion
YDL056W	YDL056W	MBP1	hom	Verified	0.914624998145531	0.1801942653271	no	914	0.187441598410123	645	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes	positive regulation of transcription involved in G1/S phase of mitotic cell cycle	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	MBF transcription complex|nucleus
YHR207C	YHR207C	SET5	hom	Verified	0.913413263716023	0.180512616151457	no	915	0.188550637077555	665	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus	histone lysine methylation	S-adenosylmethionine-dependent methyltransferase activity	nuclear chromatin|nucleus|cytoplasm
YML128C	YML128C	MSC1	hom	Verified	0.912219914505713	0.18082648131857	no	916	0.191414407884853	631	NA	FT	CELL CYCLE	ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated	reciprocal meiotic recombination	molecular_function	mitochondrion|endoplasmic reticulum|plasma membrane
YDR430C	YDR430C	CYM1	hom	Verified	0.910563381345871	0.181262736049951	no	917	0.149061544806744	454	NA	FT	PROTEOLYSIS	MITOCHONDRION		Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology	proteolysis|proteolysis involved in cellular protein catabolic process	metalloendopeptidase activity	mitochondrion|mitochondrial intermembrane space
YML129C	YML129C	COX14	hom	Verified	0.910487816745094	0.181282652000849	no	918	0.18800749022189	633	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes	mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation	molecular_function	mitochondrial envelope|mitochondrion|integral to membrane|mitochondrial inner membrane|mitochondrial matrix|extrinsic to membrane
YOL079W_d	YOL079W	YOL079W	hom	Dubious	0.909546071389659	0.181530975159231	no	919	0.20201723841551	651	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR127W	YOR127W	RGA1	hom	Verified	0.904324018387997	0.182911807271335	no	920	0.187925056372938	648	NA	FT	SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress	budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth	Rho GTPase activator activity	cellular bud neck split septin rings
YHL024W	YHL024W	RIM4	hom	Verified	0.904286053494418	0.182921870011877	no	921	0.204222368523683	675	NA	FT	CELL CYCLE			Putative RNA-binding protein required for the expression of early and middle sporulation genes	meiosis|reciprocal meiotic recombination|sporulation resulting in formation of a cellular spore|premeiotic DNA replication	RNA binding	cytoplasm
YPL133C	YPL133C	RDS2	hom	Verified	0.903925026432474	0.183017578881095	no	922	0.151371067151816	509	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|cellular response to xenobiotic stimulus|positive regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YOR382W	YOR382W	FIT2	hom	Verified	0.903538984313393	0.18311995384373	no	923	0.144372227719659	477	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall	siderophore transport	molecular_function	fungal-type cell wall
YER067W	YER067W	RGI1	hom	Verified	0.902732316489004	0.183333990314778	no	924	0.154196830398411	518	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|PLASMA MEMBRANE		Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress	energy reserve metabolic process	molecular_function	cell periphery|nucleus|cytoplasm
YOR258W	YOR258W	HNT3	hom	Verified	0.902448769305469	0.183409262084743	no	925	0.216480042186175	756	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress	response to DNA damage stimulus	DNA 5'-adenosine monophosphate hydrolase activity	nucleus|cytoplasm
YPL038W-A_p	YPL038W-A	YPL038W-A	hom	Uncharacterized	0.898827785359953	0.184372198889525	no	926	0.158989944373904	558	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YDR371W_p	YDR371W	CTS2	hom	Uncharacterized	0.896085034355951	0.185103674672378	no	927	0.170132975450671	565	NA	FT	CARBOHYDRATE METABOLISM			Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect	sporulation resulting in formation of a cellular spore	molecular_function	cytoplasm
YEL063C	YEL063C	CAN1	hom	Verified	0.895845551511893	0.185167628817571	no	928	0.2021228829502	717	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity	mitochondrion|integral to membrane|membrane raft|plasma membrane
YGL242C_p	YGL242C	YGL242C	hom	Uncharacterized	0.895636704150764	0.185223412926244	no	929	0.207968195755441	674	NA					Putative protein of unknown function; deletion mutant is viable	biological_process	molecular_function	cellular_component
YBL066C	YBL066C	SEF1	hom	Verified	0.895448269242935	0.185273753728405	no	930	0.156534027103378	571	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative transcription factor, has homolog in Kluyveromyces lactis	biological_process	molecular_function	cellular_component
YGR291C_d	YGR291C	YGR291C	hom	Dubious	0.894761548341264	0.185457284623145	no	931	0.197538580542603	660	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL145W	YNL145W	MFA2	hom	Verified	0.893951302836752	0.185673973385053	no	932	0.16049038585358	603	NA	FT	SIGNALING	PLASMA MEMBRANE		Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YLR295C	YLR295C	ATP14	hom	Verified	0.891765277447085	0.186259378286252	no	933	0.215414304839327	721	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress	cristae formation|mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YDL119C_p	YDL119C	YDL119C	hom	Uncharacterized	0.890169147442414	0.186687534189567	no	934	0.196958767637261	735	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria	transport	transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDR263C	YDR263C	DIN7	hom	Verified	0.888749881253298	0.187068758363159	no	935	0.1965045212172	653	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination	DNA repair	nuclease activity	mitochondrion
YPL277C_p	YPL277C	YPL277C	hom	Uncharacterized	0.888327421471945	0.187182326757409	no	936	0.170219286477885	598	NA					Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels	biological_process	molecular_function	membrane
YNL146W_p	YNL146W	YNL146W	hom	Uncharacterized	0.88800417136413	0.187269253747859	no	937	0.189799245004018	641	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YLR214W	YLR214W	FRE1	hom	Verified	0.887967193680865	0.187279199213733	no	938	0.162634711789597	560	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YJR063W	YJR063W	RPA12	hom	Verified	0.887442639680404	0.187420317695455	no	939	0.219763931506087	778	NA	FF|FT		NUCLEUS		RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex	termination of RNA polymerase I transcription|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	molecular_function	DNA-directed RNA polymerase I complex
YGL079W_p	YGL079W	KXD1	hom	Uncharacterized	0.887168191586212	0.187494177455947	no	940	0.173025180735782	569	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YDL203C	YDL203C	ACK1	hom	Verified	0.886462310098271	0.187684227642512	no	941	0.186442904615288	589	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria	fungal-type cell wall organization|positive regulation of signal transduction	molecular_function	mitochondrion
YMR171C	YMR171C	EAR1	hom	Verified	0.884526964513429	0.188205906531336	no	942	0.18619335787958	629	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT			Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	molecular_function	endosome
YDR083W	YDR083W	RRP8	hom	Verified	0.884154961184447	0.188306283702179	no	943	0.171902323051056	600	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|CHROMOSOME		Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1	rRNA processing	methyltransferase activity	nucleolus
YOL006C	YOL006C	TOP1	hom	Verified	0.883179195146692	0.188569730264493	no	944	0.191413471238209	665	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination	nuclear migration|chromatin assembly or disassembly|DNA topological change|DNA strand elongation involved in DNA replication|regulation of mitotic recombination|chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|mitotic chromosome condensation|transcription elongation from RNA polymerase II promoter	DNA topoisomerase type I activity	replication fork protection complex|nucleolus|nucleus
YDR139C	YDR139C	RUB1	hom	Verified	0.882916103458739	0.188640801130036	no	945	0.158984410341852	529	NA					Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)	protein neddylation	protein tag	cytoplasm
YDR344C_d	YDR344C	YDR344C	hom	Dubious	0.882911093569128	0.188642154648046	no	946	0.184231119352098	618	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL241W	YGL241W	KAP114	hom	Verified	0.882800828864336	0.18867194629423	no	947	0.184650695924158	595	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress	protein import into nucleus|transcription factor import into nucleus	protein transporter activity	integral to membrane|nucleus|cytoplasm
YJL217W	YJL217W	REE1	hom	Verified	0.879874956883315	0.189463526315398	no	948	0.190731635490742	669	NA					Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle	biological_process	molecular_function	cytoplasm
YOL007C	YOL007C	CSI2	hom	Verified	0.878496665005533	0.189837123378595	no	949	0.182191888891918	622	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene	biological_process	molecular_function	fungal-type vacuole|cellular bud neck
YGL041C-B_p	YGL041C-B	YGL041C-B	hom	Uncharacterized	0.877435357692726	0.190125107699878	no	950	0.172539399523705	560	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YLR180W	YLR180W	SAM1	hom	Verified	0.873852433669223	0.191099310736467	no	951	0.176983777431467	595	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication	methionine metabolic process|S-adenosylmethionine biosynthetic process	methionine adenosyltransferase activity	cytoplasm
YLR027C	YLR027C	AAT2	hom	Verified	0.871740469528951	0.191674988614769	no	952	0.240586329251174	801	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells	aspartate biosynthetic process	L-aspartate:2-oxoglutarate aminotransferase activity	cytosol|peroxisome
YML029W	YML029W	USA1	hom	Verified	0.871114036307389	0.191845945418232	no	953	0.177129182810408	594	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p	ER-associated protein catabolic process|mRNA splicing, via spliceosome|positive regulation of protein oligomerization	protein complex scaffold	Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YGL255W	YGL255W	ZRT1	hom	Verified	0.869842290157257	0.192193298396242	no	954	0.159040654637039	512	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor	high-affinity zinc ion transport	high affinity zinc uptake transmembrane transporter activity	integral to membrane|integral to plasma membrane
YGL013C	YGL013C	PDR1	hom	Verified	0.868840247722066	0.192467257809021	no	955	0.314725269178212	1106	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RSC COMPLEX	Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication	Unknown|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YHL002W	YHL002W	HSE1	hom	Verified	0.86839645089326	0.192588668557367	no	956	0.204947005098441	639	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes	late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding	endosome|ESCRT-0 complex
YDR226W	YDR226W	ADK1	hom	Verified	0.86833175239843	0.192606372215593	no	957	0.202923034990131	737	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress	ADP biosynthetic process|DNA replication initiation|nucleotide metabolic process	adenylate kinase activity	mitochondrion|mitochondrial intermembrane space|cytoplasm
YHR121W	YHR121W	LSM12	hom	Verified	0.867811429764568	0.192748785942237	no	958	0.18799931925512	646	NA	FT		NUCLEUS		Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress	RNA metabolic process	RNA binding	ribosome|nucleus|cytoplasmic stress granule|cytoplasm
YDL062W_d	YDL062W	YDL062W	hom	Dubious	0.866988735468901	0.192974090863111	no	959	0.198627003466951	660	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential	Unknown	Unknown	Unknown
YHR157W	YHR157W	REC104	hom	Verified	0.866781509034869	0.19303086771119	no	960	0.178418955726592	650	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YNR048W	YNR048W	YNR048W	hom	Verified	0.866082143488476	0.193222558379199	no	961	0.195031273189512	670	NA					Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication	response to drug	phospholipid-translocating ATPase activity	integral to membrane
YDR253C	YDR253C	MET32	hom	Verified	0.865933895162068	0.19326320701479	no	962	0.215934980400032	751	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication	regulation of mitotic cell cycle|regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YCR050C_p	YCR050C	YCR050C	hom	Uncharacterized	0.865817774062475	0.193295050238236	no	963	0.164850702093327	615	NA					Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein	biological_process	molecular_function	cellular_component
YJL189W	YJL189W	RPL39	hom	Verified	0.865632664924354	0.193345818275839	no	964	0.193710403431148	649	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR061W	YLR061W	RPL22A	hom	Verified	0.865077690236849	0.193498074407056	no	965	0.201798536149966	676	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR120C	YBR120C	CBP6	hom	Verified	0.863053703050421	0.194053970480803	no	966	0.187247153571091	626	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly	ribosome binding	mitochondrion|mitochondrial ribosome
YPL065W	YPL065W	VPS28	hom	Verified	0.862671894059173	0.194158944808414	no	967	0.217219404693825	772	NA	FF|FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	protein complex binding	endosome|ESCRT I complex
YOR039W	YOR039W	CKB2	hom	Verified	0.862513565141429	0.194202485806762	no	968	0.190731244785992	654	NA	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase	regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase inhibitor activity|protein kinase regulator activity	protein kinase CK2 complex|UTP-C complex|CURI complex
YOL052C	YOL052C	SPE2	hom	Verified	0.860614770656252	0.194725124036137	no	969	0.209731404595545	672	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically	spermidine biosynthetic process|spermine biosynthetic process|pantothenate biosynthetic process	adenosylmethionine decarboxylase activity	nucleus|cytoplasm
YDR193W_d	YDR193W	YDR193W	hom	Dubious	0.858661261014429	0.195263714522351	no	970	0.161465381109045	566	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR207C	YGR207C	CIR1	hom	Verified	0.858429043995573	0.195327797831177	no	971	0.156491867787031	515	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YFL011W	YFL011W	HXT10	hom	Verified	0.85782796065997	0.195493733933098	no	972	0.219466661560487	765	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Putative hexose transporter, expressed at low levels and expression is repressed by glucose	hexose transport|transmembrane transport	galactose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YGR194C	YGR194C	XKS1	hom	Verified	0.856475484922112	0.1958674136208	no	973	0.165285257868864	565	NA	FT	CARBOHYDRATE METABOLISM			Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains	xylulose catabolic process	xylulokinase activity	cytoplasm
YCR084C	YCR084C	TUP1	hom	Verified	0.855914408795933	0.196022562189159	no	974	0.188439943257387	677	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes	nucleosome positioning|regulation of transcription from RNA polymerase II promoter in response to osmotic stress|histone exchange|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown	ubiquitin binding|histone deacetylase binding|histone binding|phosphatidylinositol-3,5-bisphosphate binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|mediator complex binding	nucleus|transcriptional repressor complex
YDL114W_p	YDL114W	YDL114W	hom	Uncharacterized	0.855441002438642	0.19615352631306	no	975	0.199380192528819	659	NA	FT	OXIDATION-REDUCTION PROCESS			Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene	biological_process	molecular_function	integral to membrane
YMR135C	YMR135C	GID8	hom	Verified	0.853994683867114	0.196553967472643	no	976	0.201388871222934	678	NA	FT	KETONE METABOLISM|CELL CYCLE|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|traversing start control point of mitotic cell cycle	molecular_function	nucleus|GID complex|cytoplasm
YDR003W	YDR003W	RCR2	hom	Verified	0.853576319809327	0.196669891915982	no	977	0.175450228307577	602	NA	FT	VESICLE-MEDIATED TRANSPORT			Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication	vesicle-mediated transport	molecular_function	vesicle|integral to membrane|fungal-type vacuole|cytoplasm
YDR481C	YDR481C	PHO8	hom	Verified	0.852198196231086	0.197052048807378	no	978	0.215780161606513	729	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN	nicotinamide nucleotide metabolic process|protein dephosphorylation	nucleotide phosphatase activity|alkaline phosphatase activity	fungal-type vacuole membrane
YEL041W	YEL041W	YEF1	hom	Verified	0.851955885931504	0.197119288447652	no	979	0.223240985258787	728	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication	NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	cellular_component
YER038W-A_d	YER038W-A	YER038W-A	hom	Dubious	0.85164607604474	0.19720527903587	no	980	0.204105759164079	651	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria	Unknown	Unknown	Unknown
YOL083W	YOL083W	ATG34	hom	Verified	0.8495130044767	0.197797948535776	no	981	0.177037525374317	561	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS			Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog	protein complex assembly|protein complex localization	protein binding, bridging	CVT complex
YOL077W-A	YOL077W-A	ATP19	hom	Verified	0.848423822983244	0.198100989968838	no	982	0.176831082459134	606	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase	mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YFL054C_p	YFL054C	YFL054C	hom	Uncharacterized	0.846733921434507	0.198571723419666	no	983	0.188581461062574	622	NA					Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol	water transport|transmembrane transport	water channel activity|glycerol transmembrane transporter activity|transporter activity	integral to membrane
YDL138W	YDL138W	RGT2	hom	Verified	0.846332944539916	0.198683517190765	no	984	0.167605965597191	528	NA	FT	SIGNALING	PLASMA MEMBRANE		Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication	glucose transport|signal transduction|detection of glucose	glucose transmembrane transporter activity|receptor activity|glucose binding	integral to membrane|plasma membrane
YEL061C	YEL061C	CIN8	hom	Verified	0.845393294508905	0.198945643568793	no	985	0.21193902947461	760	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation	mitotic anaphase B|microtubule depolymerization|spindle pole body separation|mitotic spindle organization in nucleus|mitotic sister chromatid segregation	plus-end-directed microtubule motor activity|minus-end-directed microtubule motor activity	spindle microtubule|kinesin complex|mitochondrion|condensed nuclear chromosome kinetochore|kinetochore microtubule|astral microtubule
YHR006W	YHR006W	STP2	hom	Verified	0.84529129103981	0.198974111165822	no	986	0.174605072560698	600	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|PLASMA MEMBRANE		Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YAR027W	YAR027W	UIP3	hom	Verified	0.844833216139902	0.199101983076587	no	987	0.195090788291083	619	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE		Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family	biological_process	molecular_function	nuclear envelope
YDR099W	YDR099W	BMH2	hom	Verified	0.844239629264144	0.199267756868544	no	988	0.210788591910489	668	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	glycogen metabolic process|ascospore formation|Ras protein signal transduction|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|DNA damage checkpoint|DNA replication initiation|signal transduction involved in filamentous growth|pseudohyphal growth|fungal-type cell wall chitin biosynthetic process|pre-replicative complex assembly	DNA replication origin binding|phosphoserine binding	nucleus|plasma membrane
YBR266C_d	YBR266C	SLM6	hom	Dubious	0.842949662368424	0.199628298458817	no	989	0.207770795330818	676	NA					Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase	Unknown	Unknown	Unknown
YFL052W_p	YFL052W	YFL052W	hom	Uncharacterized	0.84267280934272	0.199705729120543	no	990	0.171810322018256	558	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity	biological_process	DNA binding	cellular_component
YGR171C	YGR171C	MSM1	hom	Verified	0.842362189324648	0.199792625290365	no	991	0.20920506301574	694	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p	methionyl-tRNA aminoacylation	methionine-tRNA ligase activity	mitochondrion
YOR354C	YOR354C	MSC6	hom	Verified	0.840071934393953	0.200434027507599	no	992	0.211010452637631	710	NA	FT	CELL CYCLE	MITOCHONDRION		Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	reciprocal meiotic recombination	molecular_function	mitochondrion
YKL087C	YKL087C	CYT2	hom	Verified	0.839777640331867	0.200516536238773	no	993	0.200813889854588	673	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	MITOCHONDRION		Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1	cytochrome c-heme linkage	holocytochrome-c synthase activity	mitochondrion|mitochondrial intermembrane space
YFL051C_p	YFL051C	YFL051C	hom	Uncharacterized	0.838955964051235	0.200747010603999	no	994	0.172168731759103	583	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; YFL051C is not an essential gene	biological_process	molecular_function	cellular_component
YJR122W	YJR122W	IBA57	hom	Verified	0.837646898796476	0.201114522400008	no	995	0.246784567663796	867	NA	FF|FT	COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system	iron-sulfur cluster assembly	molecular_function	mitochondrion|mitochondrial matrix
YML081W	YML081W	TDA9	hom	Verified	0.836344475581636	0.201480569632352	no	996	0.188443760910969	626	NA	FT		NUCLEUS		DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication	biological_process	sequence-specific DNA binding	nucleus
YNL265C	YNL265C	IST1	hom	Verified	0.836281406535899	0.201498305373711	no	997	0.214217104601566	721	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p	late endosome to vacuole transport via multivesicular body sorting pathway	molecular_function	endosome|cytoplasm
YGR217W	YGR217W	CCH1	hom	Verified	0.833667707637302	0.202234130010179	no	998	0.201011471605533	673	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together	calcium ion transport	voltage-gated calcium channel activity|calcium channel activity	integral to membrane|plasma membrane
YBR208C	YBR208C	DUR1,2	hom	Verified	0.832822452595445	0.20247243496647	no	999	0.188473365932818	652	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress	allantoin catabolic process|urea catabolic process	urea carboxylase activity|allophanate hydrolase activity	cytoplasm
YFL020C	YFL020C	PAU5	hom	Verified	0.831584980331687	0.202821621414782	no	1000	0.182288189103038	631	NA					Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme	biological_process	molecular_function	integral to membrane|cytoplasm
YML087C	YML087C	AIM33	hom	Verified	0.831540701132068	0.202834122658289	no	1001	0.193673274146968	632	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YBL006C	YBL006C	LDB7	hom	Verified	0.830863959241335	0.203025242896575	no	1002	0.281875646803075	993	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions	ATP-dependent chromatin remodeling|cell wall mannoprotein biosynthetic process|nucleosome disassembly|transcription elongation from RNA polymerase II promoter	DNA translocase activity	RSC complex
YDR218C	YDR218C	SPR28	hom	Verified	0.830856421373558	0.203027372288574	no	1003	0.181553735647992	606	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation	sexual sporulation resulting in formation of a cellular spore	structural molecule activity	spindle microtubule|meiotic spindle|septin complex|prospore membrane|ascospore wall
YDL086W_p	YDL086W	YDL086W	hom	Uncharacterized	0.830221028546157	0.203206914009271	no	1004	0.157155234386279	546	NA	FT		MITOCHONDRION		Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene	biological_process	carboxymethylenebutenolidase activity	mitochondrion|cytoplasm
YBR173C	YBR173C	UMP1	hom	Verified	0.829136465027274	0.203513595873795	no	1005	0.189428225530922	632	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly	proteasome assembly|response to DNA damage stimulus|ubiquitin-dependent protein catabolic process	molecular_function	nucleus|cytoplasm
YOR321W	YOR321W	PMT3	hom	Verified	0.828674128951499	0.203644414460836	no	1006	0.192202259333267	689	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication	protein O-linked glycosylation|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YDR507C	YDR507C	GIN4	hom	Verified	0.827068896868343	0.20409900606257	no	1007	0.212610092989209	762	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication	protein autophosphorylation|budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly	protein kinase activity	cellular bud neck
YGL064C	YGL064C	MRH4	hom	Verified	0.825885049476929	0.204434651134949	no	1008	0.217478009281225	730	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	MITOCHONDRION		Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function	RNA metabolic process	RNA helicase activity	mitochondrion
YLL051C	YLL051C	FRE6	hom	Verified	0.825613739339813	0.204511619386443	no	1009	0.171455923533009	600	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels	intracellular sequestering of iron ion|copper ion import	ferric-chelate reductase activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YFL049W	YFL049W	SWP82	hom	Verified	0.825366183872552	0.204581863695472	no	1010	0.189738265623883	641	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	RSC COMPLEX	Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex|nucleus
YER048C	YER048C	CAJ1	hom	Verified	0.824857874554008	0.204726142373007	no	1011	0.192717309554111	662	NA	FT		NUCLEUS		Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly	protein folding	chaperone binding	nucleus
YMR274C	YMR274C	RCE1	hom	Verified	0.824705403294723	0.204769431660618	no	1012	0.212474053467276	739	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone	CAAX-box protein processing|peptide pheromone maturation|protein processing	metalloendopeptidase activity	integral to endoplasmic reticulum membrane|integral to membrane
YJL013C	YJL013C	MAD3	hom	Verified	0.824401973715204	0.204855596881705	no	1013	0.18474180109979	636	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover	distributive segregation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	mitotic checkpoint complex
YDR523C	YDR523C	SPS1	hom	Verified	0.822534861118857	0.205386277173671	no	1014	0.154483711717863	548	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis	ascospore wall assembly|ascospore formation|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	nucleus|prospore membrane|cytoplasm
YNL277W-A_p	YNL277W-A	YNL277W-A	hom	Uncharacterized	0.822339168789139	0.205441945081735	no	1015	0.171753873258642	564	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL025C	YNL025C	SSN8	hom	Verified	0.82163383906082	0.205642662079973	no	1016	0.222421663818587	771	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance	positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter	cyclin-dependent protein kinase regulator activity	mediator complex
YPR072W	YPR072W	NOT5	hom	Verified	0.821034364927762	0.205813347025679	no	1017	0.206834811860157	686	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation	deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination	ubiquitin-protein ligase activity	CCR4-NOT core complex|cytoplasm
YGR199W	YGR199W	PMT6	hom	Verified	0.818887209482239	0.206425384035411	no	1018	0.199306205327072	666	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases	protein O-linked glycosylation|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane
YPL120W	YPL120W	VPS30	hom	Verified	0.818549121437486	0.206521852686559	no	1019	0.213938382814807	760	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1	phosphatidylinositol biosynthetic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|retrograde transport, endosome to Golgi|macroautophagy|CVT pathway|late endosome to vacuole transport	1-phosphatidylinositol-3-kinase activity	phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|extrinsic to membrane|cytoplasm
YDR363W-A	YDR363W-A	SEM1	hom	Verified	0.816173393980643	0.207200485796785	no	1020	0.215639594634374	782	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|PROTEOLYSIS|RNA LOCALIZATION	NUCLEUS		Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress	proteasome assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of cell cycle|mRNA export from nucleus|exocytosis|filamentous growth|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|proteasome storage granule|proteasome regulatory particle, lid subcomplex
YDR234W	YDR234W	LYS4	hom	Verified	0.8160252006953	0.20724286127448	no	1021	0.217676424097347	742	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway	lysine biosynthetic process via aminoadipic acid	homoaconitate hydratase activity	mitochondrion
YPL274W	YPL274W	SAM3	hom	Verified	0.815972678387836	0.207257881119312	no	1022	0.244664233469245	774	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p	spermidine transport|putrescine transport|S-adenosylmethionine transport	S-adenosylmethionine transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity	integral to membrane|plasma membrane
YML101C-A_d	YML101C-A	YML101C-A	hom	Dubious	0.815469627510532	0.207401771573648	no	1023	0.197700439021383	655	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR034C_p	YMR034C	YMR034C	hom	Uncharacterized	0.811420472912227	0.20856212301857	no	1024	0.217808944090497	695	NA					Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene	biological_process	sterol transporter activity	integral to membrane
YJL204C	YJL204C	RCY1	hom	Verified	0.810744089314538	0.208756324191222	no	1025	0.26249615704285	950	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	GOLGI APPARATUS|SITE OF POLARIZED GROWTH		F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth	early endosome to Golgi transport|endocytosis	SNARE binding	endosome|Golgi apparatus|site of polarized growth
YLR193C	YLR193C	UPS1	hom	Verified	0.810652398400825	0.208782658403283	no	1026	0.181739059868035	623	NA	FT	LIPID METABOLISM	MITOCHONDRION		Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI	Unknown|cardiolipin metabolic process	molecular_function	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial intermembrane space
YCL058C	YCL058C	FYV5	hom	Verified	0.808456786858742	0.209413836439417	no	1027	0.199501026145651	674	NA	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS			Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis	pheromone-dependent signal transduction involved in conjugation with cellular fusion|cellular ion homeostasis	molecular_function	integral to membrane
YNL224C	YNL224C	SQS1	hom	Verified	0.806279720953062	0.210040790320936	no	1028	0.202376470653016	729	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM	NUCLEUS		Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress	positive regulation of helicase activity|positive regulation of ATPase activity|mRNA splicing, via spliceosome|maturation of SSU-rRNA|rRNA processing	molecular_function	preribosome, small subunit precursor|nucleus|preribosome, large subunit precursor|90S preribosome|cytoplasm
YNL319W_d	YNL319W	YNL319W	hom	Dubious	0.804311015049013	0.210608688874307	no	1029	0.224905317397247	790	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14	Unknown	Unknown	Unknown
YBR295W	YBR295W	PCA1	hom	Verified	0.804131232425872	0.210660594341746	no	1030	0.206220225109607	696	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	PLASMA MEMBRANE		Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function	cadmium ion transport|cellular iron ion homeostasis|cellular metal ion homeostasis|transmembrane transport	copper-transporting ATPase activity|cadmium-exporting ATPase activity|copper ion binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	integral to membrane|plasma membrane
YDR148C	YDR148C	KGD2	hom	Verified	0.803180036379186	0.210935341281059	no	1031	0.212038473381424	732	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated	tricarboxylic acid cycle|mitochondrial genome maintenance|2-oxoglutarate metabolic process	dihydrolipoyllysine-residue succinyltransferase activity	mitochondrial nucleoid|mitochondrion|mitochondrial oxoglutarate dehydrogenase complex
YER060W-A	YER060W-A	FCY22	hom	Verified	0.801778536338623	0.21134053826732	no	1032	0.183528146613053	587	NA					Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function	transmembrane transport	nucleobase transmembrane transporter activity	integral to membrane
YNL227C	YNL227C	JJJ1	hom	Verified	0.800034058532973	0.211845532248511	no	1033	0.171187527598081	582	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION	RIBOSOME	Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis	ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|endocytosis|regulation of cell size|rRNA processing	ATPase activator activity	cytosol|mitochondrion|cytosolic large ribosomal subunit|nucleolus|cytoplasm
YER180C-A	YER180C-A	SLO1	hom	Verified	0.799964900776593	0.21186556667468	no	1034	0.229639533414892	820	NA	FT	PROTEIN LOCALIZATION			Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO	intracellular protein transport	small GTPase regulator activity	cytoplasm
YDR046C	YDR046C	BAP3	hom	Verified	0.799395903906193	0.212030442402091	no	1035	0.192326712874172	628	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YDR175C	YDR175C	RSM24	hom	Verified	0.799394122226184	0.212030958789511	no	1036	0.222592457659882	760	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YOR211C	YOR211C	MGM1	hom	Verified	0.798984046775139	0.212149831235713	no	1037	0.203324331720374	685	NA	FT	MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy	mitochondrion organization|mitochondrial genome maintenance|mitochondrial fusion	GTPase activity	intrinsic to mitochondrial inner membrane|extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial inner boundary membrane|mitochondrial crista|mitochondrial intermembrane space
YOL071W	YOL071W	EMI5	hom	Verified	0.798955165705437	0.212158204732754	no	1038	0.1733280303115	568	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)	protein-FAD linkage|cellular respiration|mitochondrial electron transport, succinate to ubiquinone|ascospore formation|tricarboxylic acid cycle|positive regulation of transcription from RNA polymerase II promoter	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial matrix
YPR036W	YPR036W	VMA13	hom	Verified	0.798885759992103	0.212178328341747	no	1039	0.266989688373278	934	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane|integral to membrane
YIL041W	YIL041W	GVP36	hom	Verified	0.798757869510619	0.212215412044898	no	1040	0.230897523215853	756	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis	vacuole organization|endocytosis|establishment or maintenance of actin cytoskeleton polarity	molecular_function	integral to Golgi membrane|cytoplasm
YGL224C	YGL224C	SDT1	hom	Verified	0.798146092418925	0.212392858103069	no	1041	0.20843354283673	715	NA					Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives	pyrimidine nucleobase metabolic process	nucleotidase activity	cellular_component
YOR007C	YOR007C	SGT2	hom	Verified	0.794444127207034	0.213468461844524	no	1042	0.195694484138135	661	NA	FT	PROTEIN LOCALIZATION			Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress	response to heat|posttranslational protein targeting to membrane	molecular_function	TRC complex|cytoplasm
YBR141C_p	YBR141C	YBR141C	hom	Uncharacterized	0.793760269633571	0.213667503072463	no	1043	0.197748086271246	637	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleolus
YKL119C	YKL119C	VPH2	hom	Verified	0.792747555777513	0.213962458590448	no	1044	0.221649121849714	739	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)	vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification	molecular_function	endoplasmic reticulum membrane
YNL327W	YNL327W	EGT2	hom	Verified	0.792603005265287	0.214004578621662	no	1045	0.217223983186387	716	NA	FT	CELL CYCLE|CELL DIVISION			Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner	cytokinesis	cellulase activity	fungal-type cell wall|cellular bud|cell septum
YDR258C	YDR258C	HSP78	hom	Verified	0.792342452687381	0.214080512248533	no	1046	0.193191878322348	651	NA	FT	PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates	positive regulation of mitochondrial translation in response to stress|protein refolding|protein stabilization|protein import into mitochondrial matrix|mitochondrial genome maintenance|protein unfolding|cellular response to heat	misfolded protein binding|ATPase activity	mitochondrion|mitochondrial matrix
YHR087W	YHR087W	RTC3	hom	Verified	0.792244183050103	0.214109155338241	no	1047	0.241069743401721	856	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress	RNA metabolic process	molecular_function	nucleus|cytoplasm
YOR221C	YOR221C	MCT1	hom	Verified	0.791044235821857	0.214459089149384	no	1048	0.254016699757669	872	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling	fatty acid metabolic process|aerobic respiration	[acyl-carrier-protein] S-malonyltransferase activity	mitochondrion
YKR094C	YKR094C	RPL40B	hom	Verified	0.79083609123007	0.214519823004409	no	1049	0.20734599242461	732	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION	NUCLEUS|MITOCHONDRION	RIBOSOME	Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication	cytoplasmic translation|protein ubiquitination|ribosome biogenesis	structural constituent of ribosome|protein tag	mitochondrion|cytosolic large ribosomal subunit
YDR501W	YDR501W	PLM2	hom	Verified	0.789988335176809	0.214767290351791	no	1050	0.190703471877383	637	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication	response to DNA damage stimulus	chromatin binding	nuclear chromatin
YPL102C_d	YPL102C	YPL102C	hom	Dubious	0.78932138228032	0.214962096214213	no	1051	0.212533954407461	718	NA					Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4	Unknown	Unknown	Unknown
YDR056C_p	YDR056C	YDR056C	hom	Uncharacterized	0.788560714711921	0.215184399787698	no	1052	0.206104910639665	711	NA	FT		ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein	biological_process	molecular_function	endoplasmic reticulum
YGR084C	YGR084C	MRP13	hom	Verified	0.787617355532712	0.215460279898213	no	1053	0.19565732926438	682	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YIL153W	YIL153W	RRD1	hom	Verified	0.787489440717194	0.215497703659368	no	1054	0.235438790060819	826	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION	NUCLEUS|CHROMOSOME		Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	DNA repair|mitotic spindle organization in nucleus|G1/S transition of mitotic cell cycle|response to osmotic stress|regulation of transcription from RNA polymerase II promoter in response to stress	peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity	nuclear chromatin|nucleus|cytoplasm
YDR210W_p	YDR210W	YDR210W	hom	Uncharacterized	0.787212232283621	0.215578818869119	no	1055	0.16557851064808	549	NA	FT		PLASMA MEMBRANE		Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YJR128W_d	YJR128W	YJR128W	hom	Dubious	0.785907012618431	0.215960982951457	no	1056	0.205243014350894	665	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2	Unknown	Unknown	Unknown
YBR248C	YBR248C	HIS7	hom	Verified	0.784172897458642	0.216469332918122	no	1057	0.204710729367865	709	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor	purine nucleoside monophosphate biosynthetic process|histidine biosynthetic process	imidazoleglycerol-phosphate synthase activity	intracellular
YFL015C_d	YFL015C	YFL015C	hom	Dubious	0.783094400893982	0.216785839450425	no	1058	0.206675347976695	671	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene	Unknown	Unknown	Unknown
YHR029C	YHR029C	YHI9	hom	Verified	0.781637481418426	0.217213826414318	no	1059	0.229986591912931	758	NA	FT	SIGNALING			Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production	endoplasmic reticulum unfolded protein response	molecular_function	cellular_component
YDR067C_p	YDR067C	OCA6	hom	Uncharacterized	0.781269429737834	0.217322023028931	no	1060	0.238768921939119	802	NA					Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT	biological_process	molecular_function	cytoplasm
YBR005W	YBR005W	RCR1	hom	Verified	0.780196691633503	0.217637554689344	no	1061	0.203256580453064	698	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication	fungal-type cell wall organization|vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane
YDR151C	YDR151C	CTH1	hom	Verified	0.779072580397928	0.21796848054621	no	1062	0.224647423825395	760	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS		Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis	nuclear-transcribed mRNA catabolic process|cellular iron ion homeostasis	mRNA binding	nucleus
YEL016C	YEL016C	NPP2	hom	Verified	0.778928436617259	0.218010935850069	no	1063	0.223715593460134	735	NA	FT	NUCLEOTIDE METABOLISM			Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication	nucleoside triphosphate metabolic process	nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity	cellular_component
YER086W	YER086W	ILV1	hom	Verified	0.777110142473777	0.218546895276751	no	1064	0.254998544493263	871	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation	threonine catabolic process|isoleucine biosynthetic process	L-threonine ammonia-lyase activity	mitochondrion
YLR217W_d	YLR217W	YLR217W	hom	Dubious	0.776686109826226	0.218671991917655	no	1065	0.228201704320424	759	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6	Unknown	Unknown	Unknown
YJL124C	YJL124C	LSM1	hom	Verified	0.776229857861312	0.218806639811113	no	1066	0.248349032068386	863	NA	FF|FT	RNA PROCESSING	NUCLEUS		Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	RNA binding|RNA cap binding	mRNA cap binding complex|cytoplasmic mRNA processing body|cytoplasm
YDL219W	YDL219W	DTD1	hom	Verified	0.774284132244635	0.219381392564291	no	1067	0.198132596319834	668	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes	Unknown	D-leucyl-tRNA(Leu) deacylase activity|D-tyrosyl-tRNA(Tyr) deacylase activity	cytoplasm
YPL119C-A_p	YPL119C-A	YPL119C-A	hom	Uncharacterized	0.773905537031029	0.219493327486895	no	1068	0.216503914658815	711	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YDL192W	YDL192W	ARF1	hom	Verified	0.77371739350274	0.219548965936072	no	1069	0.248776043977722	852	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|intra-Golgi vesicle-mediated transport|macroautophagy	GTPase activity	cytosol|Golgi-associated vesicle
YLL005C	YLL005C	SPO75	hom	Verified	0.773315130992137	0.21966795155626	no	1070	0.185588590895868	611	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis	ascospore wall assembly|ascospore formation	molecular_function	integral to membrane
YDR130C	YDR130C	FIN1	hom	Verified	0.773306662857443	0.219670456751958	no	1071	0.221996732071429	722	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress	intermediate filament cytoskeleton organization|mitotic cell cycle spindle checkpoint|mitotic spindle stabilization|mitotic sister chromatid segregation	microtubule binding|structural constituent of cytoskeleton	spindle microtubule|condensed nuclear chromosome kinetochore|intermediate filament|nucleus|spindle pole body|astral microtubule|spindle
YJR087W_d	YJR087W	YJR087W	hom	Dubious	0.772464103976278	0.21991979966138	no	1072	0.212741337241241	749	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2	Unknown	Unknown	Unknown
YGR123C	YGR123C	PPT1	hom	Verified	0.772043975878947	0.22004419105206	no	1073	0.219496778778008	677	NA	FT		NUCLEUS		Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth	protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YAL055W	YAL055W	PEX22	hom	Verified	0.770142112027451	0.220607798966885	no	1074	0.23622514088987	792	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation	protein import into peroxisome matrix, receptor recycling|protein targeting to peroxisome	protein anchor	integral to peroxisomal membrane
YHR047C	YHR047C	AAP1	hom	Verified	0.769658153825066	0.220751349468334	no	1075	0.199668282989786	680	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication	glycogen metabolic process|proteolysis	aminopeptidase activity	nucleus|cytoplasm
YDL199C_p	YDL199C	YDL199C	hom	Uncharacterized	0.76940560042203	0.220826282479824	no	1076	0.196731358300471	669	NA					Putative transporter, member of the sugar porter family	transport|transmembrane transport	substrate-specific transmembrane transporter activity	integral to membrane|membrane
YML024W	YML024W	RPS17A	hom	Verified	0.768952464930036	0.220960765029876	no	1077	0.207449728356722	688	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit
YLR285W	YLR285W	NNT1	hom	Verified	0.767877016647115	0.22128012653343	no	1078	0.20272967459125	691	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING			S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination	chromatin silencing at rDNA|nicotinamide metabolic process	S-adenosylmethionine-dependent methyltransferase activity|nicotinamide N-methyltransferase activity	cytoplasm
YER060W	YER060W	FCY21	hom	Verified	0.76738297883251	0.221426922790337	no	1079	0.211980445610708	710	NA					Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function	transmembrane transport	nucleobase transmembrane transporter activity	integral to membrane
YDR269C_d	YDR269C	YDR269C	hom	Dubious	0.76677960021534	0.221606283604224	no	1080	0.212851865391768	723	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL110C	YPL110C	GDE1	hom	Verified	0.766215570353909	0.221774022634948	no	1081	0.227513982636531	782	NA	FT	LIPID METABOLISM|SIGNALING|CARBOHYDRATE METABOLISM			Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes	glycerophospholipid catabolic process	glycerophosphocholine phosphodiesterase activity	ribosome|cytoplasm
YPL036W	YPL036W	PMA2	hom	Verified	0.765976877461144	0.221845030277428	no	1082	0.193263456119887	627	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential	proton transport|regulation of pH	hydrogen-exporting ATPase activity, phosphorylative mechanism	mitochondrion|integral to membrane|plasma membrane
YGL203C	YGL203C	KEX1	hom	Verified	0.765969275781415	0.221847291879242	no	1083	0.220564212986174	733	NA	FT	PROTEOLYSIS	GOLGI APPARATUS		Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins	protein processing	serine-type carboxypeptidase activity	trans-Golgi network
YGR096W	YGR096W	TPC1	hom	Verified	0.764601630617094	0.222254398941791	no	1084	0.251457689154297	820	NA	FT		MITOCHONDRION		Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family	thiamine pyrophosphate transport	thiamine transmembrane transporter activity	integral to membrane|integral to mitochondrial inner membrane
YER068C-A_d	YER068C-A	YER068C-A	hom	Dubious	0.7643797821462	0.222320476754707	no	1085	0.216856016145966	729	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR259C	YDR259C	YAP6	hom	Verified	0.764234072264609	0.222363882701706	no	1086	0.196461476234481	672	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding transcription factor recruiting transcription factor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YOR290C	YOR290C	SNF2	hom	Verified	0.762348834512477	0.222925917464765	no	1087	0.303464712345172	1064	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|double-strand break repair|strand invasion|positive regulation of mating type switching|sucrose catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|nucleosome mobilization|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter	histone acetyl-lysine binding|RNA polymerase II activating transcription factor binding|DNA-dependent ATPase activity|nucleosomal DNA binding	SWI/SNF complex|nucleus
YNL311C	YNL311C	SKP2	hom	Verified	0.762328550674578	0.222931968962083	no	1088	0.21283978524335	698	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular protein catabolic process|regulation of sulfur amino acid metabolic process	ubiquitin-protein ligase activity|protein binding, bridging	ribosome|SCF ubiquitin ligase complex
YNR009W	YNR009W	NRM1	hom	Verified	0.762178760909656	0.222976660263893	no	1089	0.210945947051792	713	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase	negative regulation of transcription involved in G1 phase of mitotic cell cycle	repressing transcription factor binding|transcription factor binding transcription factor activity	MBF transcription complex|nucleus|cytoplasm
YHL034C	YHL034C	SBP1	hom	Verified	0.762071316995845	0.223008720392497	no	1090	0.205433394251775	752	NA	FT	TRANSLATION	NUCLEUS		Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11	negative regulation of translation|negative regulation of translation in response to stress	RNA binding|eukaryotic initiation factor 4G binding	nucleolus|cytoplasmic mRNA processing body|cytoplasm
YDL061C	YDL061C	RPS29B	hom	Verified	0.761183140327881	0.223273843456032	no	1091	0.208236341327757	719	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR178W	YDR178W	SDH4	hom	Verified	0.760848775245124	0.223373698770104	no	1092	0.252878107799601	856	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain	mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion
YKR001C	YKR001C	VPS1	hom	Verified	0.760618751146302	0.223442408280101	no	1093	0.308435780668653	1029	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION	MITOCHONDRION|CYTOSKELETON		Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis	vacuolar transport|peroxisome fission|endocytosis|actin cytoskeleton organization|protein retention in Golgi apparatus|peroxisome organization|lipid tube assembly|protein targeting to vacuole	GTPase activity	mitochondrial outer membrane|fungal-type vacuole membrane|peroxisome|actin cortical patch
YCL055W	YCL055W	KAR4	hom	Verified	0.757503798736664	0.224374045452782	no	1094	0.205003383845165	724	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone	karyogamy involved in conjugation with cellular fusion|meiosis|negative regulation of transcription from RNA polymerase II promoter by pheromones|positive regulation of transcription from RNA polymerase II promoter by pheromones|G1 phase of mitotic cell cycle	sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YGL078C	YGL078C	DBP3	hom	Verified	0.757328122309068	0.224426653327658	no	1095	0.234580557322253	805	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype	endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RNA-dependent ATPase activity	nucleolus|preribosome, large subunit precursor
YER077C_p	YER077C	YER077C	hom	Uncharacterized	0.756423193240225	0.224697753294776	no	1096	0.263783665920817	906	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport	biological_process	molecular_function	mitochondrion
YOR069W	YOR069W	VPS5	hom	Verified	0.755783707864367	0.224889443201681	no	1097	0.242024054165505	827	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity|phosphatidylinositol-3-phosphate binding	cytosol|endosome|retromer complex, outer shell|retromer complex
YHR127W	YHR127W	YHR127W	hom	Verified	0.75403295373856	0.225414717196337	no	1098	0.215825115768211	717	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS		Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis	mitotic spindle elongation	molecular_function	nucleus
YDR138W	YDR138W	HPR1	hom	Verified	0.75375162544197	0.22549918808616	no	1099	0.287992868458669	982	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p	mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|DNA recombination|response to DNA damage stimulus|transcription elongation from RNA polymerase II promoter	protein complex scaffold|nucleic acid binding	THO complex part of transcription export complex|Cdc73/Paf1 complex|nucleoplasmic THO complex
YDR057W	YDR057W	YOS9	hom	Verified	0.752802933940915	0.225784171729937	no	1100	0.21991064819304	709	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family	ER-associated protein catabolic process	oligosaccharide binding	luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum lumen
YCR007C_p	YCR007C	YCR007C	hom	Uncharacterized	0.752289355586781	0.225938533841823	no	1101	0.240825665685217	802	NA					Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene	biological_process	molecular_function	cellular_component
YOR027W	YOR027W	STI1	hom	Verified	0.749255859245632	0.226851503536303	no	1102	0.235046137798408	808	NA					Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop	protein folding	Hsp70 protein binding|Hsp90 protein binding|mRNA binding|ATPase inhibitor activity	cytoplasm
YGR126W_p	YGR126W	YGR126W	hom	Uncharacterized	0.74922154969043	0.22686184132556	no	1103	0.212815546674912	732	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YKL137W	YKL137W	CMC1	hom	Verified	0.748959127726807	0.226940920301944	no	1104	0.224945803894587	789	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif	mitochondrial respiratory chain complex IV assembly	copper ion binding	extrinsic to mitochondrial inner membrane|mitochondrial intermembrane space
YIL067C_p	YIL067C	YIL067C	hom	Uncharacterized	0.748280105266505	0.227145610989553	no	1105	0.231475343710789	775	NA					Uncharacterized protein of unknown function	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YIR021W	YIR021W	MRS1	hom	Verified	0.747310220740557	0.227438162181222	no	1106	0.199673064048837	692	NA	FT	RNA PROCESSING	MITOCHONDRION		Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA	Group I intron splicing	endodeoxyribonuclease activity|RNA binding	mitochondrion
YGR100W	YGR100W	MDR1	hom	Verified	0.746796637343864	0.227593162856502	no	1107	0.23654740121626	811	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM			Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function	intracellular protein transport	Rab GTPase activator activity	cytoplasm
YCL036W	YCL036W	GFD2	hom	Verified	0.746732402931648	0.227612553136808	no	1108	0.228150294850648	772	NA					Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLR113W	YLR113W	HOG1	hom	Verified	0.746404712010708	0.227711486844764	no	1109	0.258764620886535	876	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase II promoter by pheromones|protein phosphorylation|hyperosmotic response|response to arsenic-containing substance|osmosensory signaling pathway|positive regulation of transcription from RNA polymerase II promoter|cellular response to heat	MAP kinase activity	nucleus|cytoplasm
YOR350C	YOR350C	MNE1	hom	Verified	0.746391954063868	0.227715339107079	no	1110	0.231120568010855	791	NA	FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA	Group I intron splicing	molecular_function	mitochondrion|ribonucleoprotein complex|mitochondrial matrix
YOR378W_p	YOR378W	YOR378W	hom	Uncharacterized	0.745423416076802	0.228007896252569	no	1111	0.207811954523712	693	NA	FT		PLASMA MEMBRANE		Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene	biological_process	molecular_function	integral to membrane
YHR049W	YHR049W	FSH1	hom	Verified	0.744125657112194	0.228400229289403	no	1112	0.19615093946294	681	NA	FT		NUCLEUS		Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2	biological_process	hydrolase activity	nucleus|cytoplasm
YHR177W_p	YHR177W	YHR177W	hom	Uncharacterized	0.744092863398618	0.228410148258646	no	1113	0.230832649483517	818	NA					Putative protein of unknown function; overexpression causes a cell cycle delay or arrest	biological_process	molecular_function	cellular_component
YML053C_p	YML053C	YML053C	hom	Uncharacterized	0.741855236160465	0.229087524907968	no	1114	0.225704653134452	740	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YPR160W	YPR160W	GPH1	hom	Verified	0.741062880096288	0.229327657576064	no	1115	0.198373216783536	639	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway	glycogen catabolic process	glycogen phosphorylase activity	cytoplasm
YMR142C	YMR142C	RPL13B	hom	Verified	0.740339806620979	0.229546916440143	no	1116	0.244578090936085	834	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGL135W	YGL135W	RPL1B	hom	Verified	0.738135986843837	0.23021590866442	no	1117	0.25398433153582	875	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGL202W	YGL202W	ARO8	hom	Verified	0.737999026647244	0.230257520306756	no	1118	0.210562837913845	709	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis	aromatic amino acid family metabolic process	aromatic-amino-acid:2-oxoglutarate aminotransferase activity|2-aminoadipate transaminase activity	cytoplasm
YBR279W	YBR279W	PAF1	hom	Verified	0.737881036722968	0.230293371718831	no	1119	0.311539658228267	1077	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1	negative regulation of DNA recombination|mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of transcription-coupled nucleotide-excision repair|rRNA processing|transcription elongation from RNA polymerase I promoter|regulation of chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin silencing at rDNA|Unknown|snoRNA 3'-end processing|transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity	transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YFR006W_p	YFR006W	YFR006W	hom	Uncharacterized	0.73783466702816	0.230307462073238	no	1120	0.223147409278271	756	NA					Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene	biological_process	molecular_function	cytoplasm
YCR063W	YCR063W	BUD31	hom	Verified	0.737815518933944	0.230313280743305	no	1121	0.204223325386267	698	NA	FT	CELL CYCLE|RNA PROCESSING|CELL DIVISION	NUCLEUS		Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis	RNA splicing|mRNA splicing, via spliceosome|cellular bud site selection	molecular_function	U2 snRNP|nucleus
YDR446W	YDR446W	ECM11	hom	Verified	0.737408802763094	0.230436891947159	no	1122	0.187783614294841	621	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	NUCLEUS		Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure	fungal-type cell wall organization|reciprocal meiotic recombination	molecular_function	nucleus
YGR159C	YGR159C	NSR1	hom	Verified	0.737224315314544	0.230492974515734	no	1123	0.242771218950876	789	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION		Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis	ribosomal small subunit assembly|rRNA processing	single-stranded DNA binding|RNA binding	mitochondrion|nucleolus|nucleus
YDR199W_d	YDR199W	YDR199W	hom	Dubious	0.736661686712977	0.230664055784639	no	1124	0.256491541929062	902	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity	Unknown	Unknown	Unknown
YER056C-A	YER056C-A	RPL34A	hom	Verified	0.736659708035903	0.230664657575953	no	1125	0.197804118049944	701	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR251W	YBR251W	MRPS5	hom	Verified	0.735209170404418	0.23110605745695	no	1126	0.274755668883174	928	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YIL071C	YIL071C	PCI8	hom	Verified	0.73475284371326	0.231245015481159	no	1127	0.242274010130073	853	NA	FT		NUCLEUS		Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain	cullin deneddylation	molecular_function	signalosome
YDL225W	YDL225W	SHS1	hom	Verified	0.734678009068404	0.231267808152049	no	1128	0.201508428142249	679	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress	cytokinesis, actomyosin contractile ring assembly|G1 phase of mitotic cell cycle|barrier septum assembly|exit from mitosis|cell cycle cytokinesis|septin ring assembly|cellular bud neck septin ring organization	GTP binding	cellular bud neck septin ring|mating projection tip
YFL027C	YFL027C	GYP8	hom	Verified	0.734666441305014	0.231271331501335	no	1129	0.217073325474388	736	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM			GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport	vesicle-mediated transport	Rab GTPase activator activity	intracellular
YDL081C	YDL081C	RPP1A	hom	Verified	0.733819736899698	0.231529304942819	no	1130	0.227009611515036	760	NA	FT	TRANSLATION		RIBOSOME	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component	cytoplasmic translation|translational elongation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR241W_d	YDR241W	BUD26	hom	Dubious	0.733218809660184	0.231712492413645	no	1131	0.242532998438713	844	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YER002W	YER002W	NOP16	hom	Verified	0.732641053354269	0.231888692549021	no	1132	0.246421664919377	825	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis	ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YGL038C	YGL038C	OCH1	hom	Verified	0.732497097699769	0.231932606762559	no	1133	0.293385707408035	1024	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups	Golgi cis cisterna
YCL051W	YCL051W	LRE1	hom	Verified	0.732106357072049	0.232051827002399	no	1134	0.24702827656442	850	NA	FT	CELL WALL ORG/BIOGENESIS			Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; <br>LRE1 has a paralog, HLR1, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cellular_component
YNL322C	YNL322C	KRE1	hom	Verified	0.73131818341784	0.232292413208464	no	1135	0.248925853784304	900	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall|integral to membrane
YDR115W	YDR115W	YDR115W	hom	Verified	0.730676651004857	0.23248834028989	no	1136	0.234099211377981	756	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrial large ribosomal subunit
YGL126W	YGL126W	SCS3	hom	Verified	0.730462650671406	0.232553717454451	no	1137	0.24142116950191	813	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol	phospholipid metabolic process	molecular_function	integral to membrane|endoplasmic reticulum
YOL064C	YOL064C	MET22	hom	Verified	0.730334826481669	0.232592772657571	no	1138	0.25318403094869	888	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway	methionine biosynthetic process|hyperosmotic salinity response|sulfate assimilation	3'(2'),5'-bisphosphate nucleotidase activity	cellular_component
YGR208W	YGR208W	SER2	hom	Verified	0.725390354672163	0.23410629431481	no	1139	0.221319030085327	757	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source	L-serine biosynthetic process	phosphoserine phosphatase activity	nucleus|cytoplasm
YGR127W_p	YGR127W	YGR127W	hom	Uncharacterized	0.724057105108364	0.234515338716446	no	1140	0.214494394586725	720	NA					Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response	biological_process	molecular_function	cellular_component
YJR111C_p	YJR111C	YJR111C	hom	Uncharacterized	0.723726897248829	0.234616708391465	no	1141	0.227742180356297	808	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria	biological_process	molecular_function	mitochondrion
YLL063C	YLL063C	AYT1	hom	Verified	0.723423560256585	0.23470985039816	no	1142	0.201446017391022	644	NA					Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis	secondary metabolic process	trichothecene 3-O-acetyltransferase activity	cellular_component
YDR209C_d	YDR209C	YDR209C	hom	Dubious	0.722271702693822	0.235063723465292	no	1143	0.220967643704668	756	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.	Unknown	Unknown	Unknown
YMR202W	YMR202W	ERG2	hom	Verified	0.722133880891956	0.235106084739049	no	1144	0.353995038598985	1229	NA	FF|FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis	ergosterol biosynthetic process	C-8 sterol isomerase activity	endoplasmic reticulum
YGL077C	YGL077C	HNM1	hom	Verified	0.721502071267678	0.235300333378457	no	1145	0.218782424024047	761	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol	choline transport|ethanolamine transport|glycine betaine transport	choline transmembrane transporter activity|ethanolamine transmembrane transporter activity	integral to membrane|plasma membrane
YNL034W_p	YNL034W	YNL034W	hom	Uncharacterized	0.721224352007679	0.235385745648777	no	1146	0.228725106514879	745	NA					Putative protein of unknown function; YNL034W is not an essential gene	biological_process	molecular_function	cellular_component
YDR214W	YDR214W	AHA1	hom	Verified	0.718292280515923	0.23628854445553	no	1147	0.2470275553243	831	NA	FT	NUCLEOTIDE METABOLISM			Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress	protein folding|response to stress	ATPase activator activity|chaperone binding	cytoplasm
YFL030W	YFL030W	AGX1	hom	Verified	0.717977380257039	0.236385617001708	no	1148	0.22658103698604	752	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases	glycine biosynthetic process, by transamination of glyoxylate	alanine-glyoxylate transaminase activity	mitochondrion
YER057C	YER057C	HMF1	hom	Verified	0.717530399650833	0.236523442908891	no	1149	0.205286407677326	676	NA	FT		NUCLEUS		Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro	biological_process	molecular_function	cytosol|nucleus|cytoplasm
YFL013C	YFL013C	IES1	hom	Verified	0.717015399281469	0.236682297438156	no	1150	0.271210055148677	919	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the INO80 chromatin remodeling complex	nucleosome mobilization	molecular_function	nucleus|Ino80 complex
YDR029W_d	YDR029W	YDR029W	hom	Dubious	0.716813387865445	0.236744624926437	no	1151	0.216947078147986	724	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR402C	YDR402C	DIT2	hom	Verified	0.716646416082914	0.236796148292838	no	1152	0.251313553133465	849	NA	FT	CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS			N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s	ascospore wall assembly	oxidoreductase activity	cellular_component
YLR239C	YLR239C	LIP2	hom	Verified	0.716370692755598	0.236881243195592	no	1153	0.315720741258678	1062	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups	protein lipoylation	ligase activity	mitochondrion
YBR180W	YBR180W	DTR1	hom	Verified	0.715873895764124	0.2370346092178	no	1154	0.23283670031761	757	NA	FT	CELL WALL ORG/BIOGENESIS			Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation	ascospore wall assembly|amine transport|transmembrane transport	amine transmembrane transporter activity	integral to membrane|prospore membrane
YNL099C	YNL099C	OCA1	hom	Verified	0.715362815256581	0.237192441627647	no	1155	0.254149283140781	870	NA	FF|FT	RESPONSE TO OXIDATIVE STRESS			Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA	cellular response to oxidative stress	protein tyrosine phosphatase activity	cytoplasm
YAL058W	YAL058W	CNE1	hom	Verified	0.714918417438613	0.237329727932259	no	1156	0.227006850227436	805	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast	protein folding|ER-associated protein catabolic process	unfolded protein binding	integral to endoplasmic reticulum membrane
YDR063W	YDR063W	AIM7	hom	Verified	0.714579069998604	0.237434590756522	no	1157	0.219079153916604	743	NA	FT	CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss	actin filament debranching|negative regulation of Arp2/3 complex-mediated actin nucleation	molecular_function	nucleus|actin cortical patch|cytoplasm
YPL106C	YPL106C	SSE1	hom	Verified	0.714508655479243	0.237456352955735	no	1158	0.258343783064825	880	NA					ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication	protein folding|protein refolding	peptide binding|adenyl-nucleotide exchange factor activity|ATP binding	polysome|cytoplasm
YDR411C	YDR411C	DFM1	hom	Verified	0.714047742542264	0.237598829011796	no	1159	0.213270763570184	715	NA	FT	SIGNALING|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p	endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process	molecular_function	Doa10p ubiquitin ligase complex|integral to membrane|endoplasmic reticulum|Hrd1p ubiquitin ligase ERAD-L complex
YNL111C	YNL111C	CYB5	hom	Verified	0.71391905585647	0.237638616638498	no	1160	0.282387064923648	983	NA	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation	sterol biosynthetic process	electron carrier activity	endoplasmic reticulum membrane
YJL007C_d	YJL007C	YJL007C	hom	Dubious	0.713738698863788	0.237694385953763	no	1161	0.233980402603047	783	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL060W_p	YIL060W	YIL060W	hom	Uncharacterized	0.713607821486648	0.237734859862499	no	1162	0.255754536237049	912	NA					Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene	biological_process	molecular_function	cellular_component
YGR068C	YGR068C	ART5	hom	Verified	0.713315224108006	0.237825359452696	no	1163	0.241605727166156	797	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane	ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	cellular_component
YIL008W	YIL008W	URM1	hom	Verified	0.713198823906206	0.237861366977695	no	1164	0.245476770954159	846	NA	FT	RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response	cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|invasive growth in response to glucose limitation|tRNA wobble uridine modification	protein tag	cytosol|nucleus|cytoplasm
YER069W	YER069W	ARG5,6	hom	Verified	0.712642570721093	0.238033480979704	no	1165	0.223316783760073	715	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine	ornithine biosynthetic process|arginine biosynthetic process|regulation of transcription, DNA-dependent	N-acetyl-gamma-glutamyl-phosphate reductase activity|acetylglutamate kinase activity	mitochondrion|mitochondrial matrix
YGL166W	YGL166W	CUP2	hom	Verified	0.710848374026969	0.238589100235799	no	1166	0.248120219345789	837	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter|response to copper ion	RNA polymerase II core promoter proximal region sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|copper ion binding	nucleus
YMR096W	YMR096W	SNZ1	hom	Verified	0.709235665589663	0.239089122128006	no	1167	0.209327942738673	680	NA	FT	COFACTOR METABOLISM			Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins	pyridoxine metabolic process|thiamine biosynthetic process	protein binding	cellular_component
YBR159W	YBR159W	IFA38	hom	Verified	0.708763480705893	0.239235631862983	no	1168	0.240866939573816	846	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides	fatty acid elongation	ketoreductase activity	integral to membrane|endoplasmic reticulum
YEL043W	YEL043W	YEL043W	hom	Verified	0.708583555729762	0.239291471968783	no	1169	0.237167699809551	821	NA	FT		ENDOPLASMIC RETICULUM		Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold	biological_process	molecular_function	ribosome|endoplasmic reticulum
YOL041C	YOL041C	NOP12	hom	Verified	0.708539285970803	0.239305212275715	no	1170	0.23897716028203	799	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RNA binding	nucleolus|preribosome
YHR171W	YHR171W	ATG7	hom	Verified	0.708023935910997	0.239465196696215	no	1171	0.288472511363266	974	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	MITOCHONDRION		Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation	C-terminal protein lipidation|protein modification by small protein conjugation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway	APG8 activating enzyme activity|APG12 activating enzyme activity	cytosol|mitochondrion|membrane|pre-autophagosomal structure
YGL082W_p	YGL082W	YGL082W	hom	Uncharacterized	0.707263263391704	0.239701445300482	no	1172	0.205992509635245	697	NA	FT		NUCLEUS		Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene	biological_process	molecular_function	nucleus|plasma membrane|cytoplasm
YDR171W	YDR171W	HSP42	hom	Verified	0.706044736432678	0.240080158616075	no	1173	0.215720100438404	726	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	cytoskeleton organization	unfolded protein binding	cytoskeleton|chaperonin-containing T-complex|cytoplasm
YER087W	YER087W	AIM10	hom	Verified	0.704398925278243	0.24059218755223	no	1174	0.256241429008244	887	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	proline-tRNA ligase activity	mitochondrion
YOL065C	YOL065C	INP54	hom	Verified	0.704206952701433	0.240651950907428	no	1175	0.210743823775527	710	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins	phosphatidylinositol dephosphorylation	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	endoplasmic reticulum
YEL033W_p	YEL033W	MTC7	hom	Uncharacterized	0.703006689983852	0.241025790160386	no	1176	0.286858665317791	978	NA					Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant	biological_process	molecular_function	cellular_component
YOL062C	YOL062C	APM4	hom	Verified	0.702430015920462	0.241205515922162	no	1177	0.22139798472217	778	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport	intracellular protein transport|vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YLR315W	YLR315W	NKP2	hom	Verified	0.701434598745539	0.24151591812479	no	1178	0.286849314854669	969	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2	biological_process	molecular_function	spindle pole body|kinetochore
YGR080W	YGR080W	TWF1	hom	Verified	0.700663783165195	0.24175643148016	no	1179	0.230373411353464	820	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly	bipolar cellular bud site selection|actin polymerization or depolymerization|sequestering of actin monomers	actin monomer binding	mating projection tip|actin cortical patch
YBR187W_p	YBR187W	GDT1	hom	Uncharacterized	0.699798835126105	0.242026471168612	no	1180	0.2452090294584	873	NA					Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YDL082W	YDL082W	RPL13A	hom	Verified	0.698555861693015	0.242414817935544	no	1181	0.20602997727651	713	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR030C	YDR030C	RAD28	hom	Verified	0.698411399535546	0.242459974667125	no	1182	0.243021418153558	818	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair	DNA repair	molecular_function	nucleus
YJR099W	YJR099W	YUH1	hom	Verified	0.697714457706284	0.242677892369354	no	1183	0.224979943223379	736	NA	FT	PROTEOLYSIS			Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p	protein deubiquitination	ubiquitin-specific protease activity	cytoplasm
YGL051W	YGL051W	MST27	hom	Verified	0.697445170940283	0.242762120547532	no	1184	0.215842674941522	732	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE		Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles	vesicle organization	molecular_function	integral to membrane|Golgi apparatus|endoplasmic reticulum|plasma membrane
YGR057C	YGR057C	LST7	hom	Verified	0.695633469029162	0.24332920024236	no	1185	0.302544996164563	1006	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface	intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport	protein transporter activity	vesicle coat
YMR121C	YMR121C	RPL15B	hom	Verified	0.695338649331205	0.243421549254695	no	1186	0.214855209890616	745	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YGL243W	YGL243W	TAD1	hom	Verified	0.694528694401907	0.243675356131883	no	1187	0.225491392375968	768	NA	FT	RNA PROCESSING	NUCLEUS		tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala	tRNA modification	tRNA-specific adenosine-37 deaminase activity	nucleus
YOR315W	YOR315W	SFG1	hom	Verified	0.694463163621855	0.243695897054585	no	1188	0.23669665748519	809	NA	FT	CELL CYCLE	NUCLEUS		Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate	mitotic cell cycle|pseudohyphal growth	molecular_function	nucleus|cytoplasm
YNL011C_p	YNL011C	YNL011C	hom	Uncharacterized	0.692197721629387	0.24440658466266	no	1189	0.201363620115079	686	NA					Putative protein of unknown function; YNL011C is not an essential gene	biological_process	molecular_function	cellular_component
YMR099C	YMR099C	YMR099C	hom	Verified	0.691596867122505	0.244595264830156	no	1190	0.262664805068597	901	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS	cellular carbohydrate metabolic process	glucose-6-phosphate 1-epimerase activity	nucleus|cytoplasm
YMR031C	YMR031C	EIS1	hom	Verified	0.690694281103014	0.244878842015516	no	1191	0.255740529116371	829	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress	eisosome assembly	molecular_function	eisosome|mitochondrion|membrane raft|cytoplasm
YBR092C	YBR092C	PHO3	hom	Verified	0.689974287764188	0.245105178486939	no	1192	0.2292663695543	780	NA					Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin	phosphate-containing compound metabolic process|thiamine-containing compound metabolic process	acid phosphatase activity	cell wall-bounded periplasmic space
YNL042W	YNL042W	BOP3	hom	Verified	0.689418635067492	0.245279929872247	no	1193	0.218791658347123	725	NA	FT		NUCLEUS		Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury	cellular response to methylmercury	molecular_function	nucleus|cytoplasm
YGL125W	YGL125W	MET13	hom	Verified	0.689309681338828	0.245314203400311	no	1194	0.256818987508356	840	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway	methionine biosynthetic process	methylenetetrahydrofolate reductase (NADPH) activity	mitochondrion
YGR008C	YGR008C	STF2	hom	Verified	0.688614251118313	0.245533025230328	no	1195	0.245727143516348	830	NA	FT		MITOCHONDRION		Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress	cellular response to desiccation	molecular_function	cytoplasm
YPL096C-A	YPL096C-A	ERI1	hom	Verified	0.688571579338353	0.245546455608598	no	1196	0.279393896329897	971	NA	FT	LIPID METABOLISM|SIGNALING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein	GPI anchor biosynthetic process|Ras protein signal transduction	GTPase inhibitor activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane
YOL004W	YOL004W	SIN3	hom	Verified	0.688523443198025	0.245561606295671	no	1197	0.247246335041748	868	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL DIVISION|GENE SILENCING	NUCLEUS|CHROMOSOME		Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of transcription during meiosis|regulation of DNA-dependent DNA replication initiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|double-strand break repair via nonhomologous end joining|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle	transcription coactivator activity|transcription corepressor activity	Sin3-type complex|Rpd3S complex|Rpd3L-Expanded complex|Rpd3L complex
YGL100W	YGL100W	SEH1	hom	Verified	0.688194183139579	0.245665253247103	no	1198	0.261823859072338	955	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE	NUCLEAR PORE	Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1	nucleocytoplasmic transport	structural constituent of nuclear pore	fungal-type vacuole membrane|integral to membrane|nuclear pore|Seh1-associated complex|nuclear pore outer ring
YIL070C	YIL070C	MAM33	hom	Verified	0.687396118748312	0.245916571393738	no	1199	0.25578057070098	891	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R	aerobic respiration	molecular_function	mitochondrion|mitochondrial matrix
YGL153W	YGL153W	PEX14	hom	Verified	0.687080188947617	0.24601609883162	no	1200	0.244624695919249	846	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p	protein import into peroxisome matrix, docking	protein binding, bridging	peroxisomal membrane
YHR138C	YHR138C	YHR138C	hom	Verified	0.686381131332094	0.246236399903804	no	1201	0.246392967122576	802	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress	vacuole fusion, non-autophagic	endopeptidase inhibitor activity	cellular_component
YGR007W	YGR007W	ECT1	hom	Verified	0.686146313867022	0.246310424023731	no	1202	0.251916286412387	853	NA	FT	LIPID METABOLISM	NUCLEUS		Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases	phosphatidylethanolamine biosynthetic process	ethanolamine-phosphate cytidylyltransferase activity	nucleus|cytoplasm
YGL081W_p	YGL081W	YGL081W	hom	Uncharacterized	0.685683409462343	0.24645638545636	no	1203	0.216220319743891	683	NA					Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis	biological_process	molecular_function	cellular_component
YGR034W	YGR034W	RPL26B	hom	Verified	0.685629510851986	0.246473383593733	no	1204	0.264139088723613	911	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YLR211C_p	YLR211C	YLR211C	hom	Uncharacterized	0.684579628143456	0.246804612944351	no	1205	0.232128631149543	802	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron	biological_process	molecular_function	cytoplasm
YGL165C_d	YGL165C	YGL165C	hom	Dubious	0.684222004915245	0.246917494515045	no	1206	0.235236157283428	781	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W	Unknown	Unknown	Unknown
YGR049W	YGR049W	SCM4	hom	Verified	0.684108689336808	0.246953267643552	no	1207	0.255437887726985	839	NA	FT		MITOCHONDRION		Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to membrane
YHR080C	YHR080C	YHR080C	hom	Verified	0.68278451403568	0.247371508270555	no	1208	0.255409078977711	887	NA	FT		MITOCHONDRION		Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|ribosome
YOL033W	YOL033W	MSE1	hom	Verified	0.682506759261831	0.247459285098607	no	1209	0.284456380051929	943	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated	mitochondrial glutamyl-tRNA aminoacylation|glutamyl-tRNA aminoacylation|mitochondrial translation	glutamate-tRNA(Gln) ligase activity|glutamate-tRNA ligase activity	mitochondrion
YDR488C	YDR488C	PAC11	hom	Verified	0.682298709822349	0.247525044356201	no	1210	0.209057923072692	724	NA	FT		CYTOSKELETON		Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8	nuclear migration along microtubule|microtubule-based process	plus-end-directed microtubule motor activity|microtubule motor activity	cytoplasmic dynein complex|cytoplasmic microtubule
YMR282C	YMR282C	AEP2	hom	Verified	0.682239160746795	0.2475438680576	no	1211	0.279970296447469	941	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader	mitochondrial translational initiation	molecular_function	mitochondrion
YPL095C	YPL095C	EEB1	hom	Verified	0.681519588326746	0.247771388226531	no	1212	0.263553116308271	917	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication	medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process	short-chain carboxylesterase activity|alcohol O-octanoyltransferase activity	cellular_component
YER049W	YER049W	TPA1	hom	Verified	0.681259940243739	0.247853513240519	no	1213	0.228486492118415	734	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS	NUCLEUS		Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|translational termination	poly(A) RNA binding	nucleus
YDL191W	YDL191W	RPL35A	hom	Verified	0.681232418868031	0.247862218925771	no	1214	0.2502100861375	891	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication	cytoplasmic translation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic large ribosomal subunit|preribosome, large subunit precursor
YPL189C-A	YPL189C-A	COA2	hom	Verified	0.681040388557312	0.247922967359134	no	1215	0.243627325427417	804	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrial matrix
YBL096C_d	YBL096C	YBL096C	hom	Dubious	0.679695198634034	0.248348738403813	no	1216	0.232009439440773	797	NA					Non-essential protein of unknown function	Unknown	Unknown	Unknown
YOR067C	YOR067C	ALG8	hom	Verified	0.678439792337898	0.248746443052395	no	1217	0.28771296222563	1008	NA	FF|FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p	oligosaccharide-lipid intermediate biosynthetic process|protein N-linked glycosylation	dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	integral to membrane|endoplasmic reticulum membrane
YAL037W_p	YAL037W	YAL037W	hom	Uncharacterized	0.678422143605633	0.248752036473654	no	1218	0.259176282978392	894	NA					Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YBR278W	YBR278W	DPB3	hom	Verified	0.678285030928527	0.248795493941978	no	1219	0.256316645522296	877	NA	FT	RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication	DNA-dependent DNA replication|chromatin silencing at telomere	double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity	epsilon DNA polymerase complex
YIL086C_d	YIL086C	YIL086C	hom	Dubious	0.6769626452744	0.249214827671121	no	1220	0.234031481188568	802	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL234C	YDL234C	GYP7	hom	Verified	0.676279389155794	0.249431638070428	no	1221	0.217206947492969	751	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM			GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking	regulation of vacuole fusion, non-autophagic|vesicle-mediated transport	Rab GTPase activator activity	cytoplasm
YBR226C_d	YBR226C	YBR226C	hom	Dubious	0.671876210946797	0.250831253052747	no	1222	0.28954005716417	966	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W	Unknown	Unknown	Unknown
YAR015W	YAR015W	ADE1	hom	Verified	0.671612308661672	0.250915270139547	no	1223	0.248183443009143	862	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	nucleus|cytoplasm
YDL072C	YDL072C	YET3	hom	Verified	0.67142284369473	0.25097559822002	no	1224	0.247845979978961	868	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YHR203C	YHR203C	RPS4B	hom	Verified	0.67027507602065	0.251341226231705	no	1225	0.27940554728762	944	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YAL051W	YAL051W	OAF1	hom	Verified	0.66992449200911	0.25145296290503	no	1226	0.241385465969768	786	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GENE SILENCING	NUCLEUS		Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication	cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YPL149W	YPL149W	ATG5	hom	Verified	0.668912070266607	0.251775785047903	no	1227	0.233903270929113	800	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation	C-terminal protein lipidation|mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy|CVT pathway	Atg8 ligase activity	cytosol|Atg12-Atg5-Atg16 complex|pre-autophagosomal structure|autophagic vacuole
YFR017C	YFR017C	IGD1	hom	Verified	0.668252334642313	0.25198626692641	no	1228	0.257557407734706	870	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication	negative regulation of glycogen catabolic process	enzyme inhibitor activity	cytoplasm
YLR282C_d	YLR282C	YLR282C	hom	Dubious	0.666040841994092	0.252692497687762	no	1229	0.23779079404632	805	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition	Unknown	Unknown	Unknown
YHL042W_p	YHL042W	YHL042W	hom	Uncharacterized	0.665848800620121	0.25275387443486	no	1230	0.229941395880197	757	NA					Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	cellular_component
YBR220C_p	YBR220C	YBR220C	hom	Uncharacterized	0.665822694596767	0.252762218569994	no	1231	0.252026026934334	862	NA					Putative protein of unknown function; YBR220C is not an essential gene	biological_process	molecular_function	integral to membrane
YDR409W	YDR409W	SIZ1	hom	Verified	0.664679432879506	0.253127775694765	no	1232	0.252325606638552	840	NA	FT	CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON		SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring	protein sumoylation|chromosome segregation	SUMO ligase activity	nuclear chromatin|septin ring
YER123W	YER123W	YCK3	hom	Verified	0.664257014353785	0.253262914041215	no	1233	0.292021241140402	1029	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE		Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway	vesicle-mediated transport|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	fungal-type vacuole membrane|plasma membrane|nucleus|fungal-type vacuole
YMR318C	YMR318C	ADH6	hom	Verified	0.663834167025242	0.253398227550602	no	1234	0.242892675378526	814	NA	FT	OXIDATION-REDUCTION PROCESS			NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress	cellular aldehyde metabolic process|furaldehyde metabolic process|alcohol metabolic process	hydroxymethylfurfural reductase (NADH) activity|hydroxymethylfurfural reductase (NADPH) activity|alcohol dehydrogenase (NADP+) activity	cellular_component
YDR116C	YDR116C	MRPL1	hom	Verified	0.663713639811779	0.253436803890569	no	1235	0.245738664055947	859	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YLR139C	YLR139C	SLS1	hom	Verified	0.663513915030007	0.253500735260988	no	1236	0.279439832798307	942	NA	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery	aerobic respiration|mitochondrial translation	molecular_function	mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YGR201C_p	YGR201C	YGR201C	hom	Uncharacterized	0.662818146858462	0.253723514958847	no	1237	0.232879080873551	793	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YER033C	YER033C	ZRG8	hom	Verified	0.662453593245799	0.253840283295306	no	1238	0.25803228363348	871	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency	fungal-type cell wall organization	molecular_function	mitochondrion|cellular bud|cellular bud neck|mating projection tip|cytoplasm
YBR239C_p	YBR239C	ERT1	hom	Uncharacterized	0.660724147084782	0.254394617619637	no	1239	0.249974652771023	845	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM	NUCLEUS		Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition	biological_process	sequence-specific DNA binding	nucleus|cytoplasm
YHR093W_d	YHR093W	AHT1	hom	Dubious	0.65624420568342	0.255833505132016	no	1240	0.249009865281744	838	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region	Unknown	Unknown	Unknown
YPL061W	YPL061W	ALD6	hom	Verified	0.656235725252639	0.25583623293705	no	1241	0.259466169087008	897	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress	response to salt stress|NADPH regeneration|acetate biosynthetic process	aldehyde dehydrogenase [NAD(P)+] activity	cytosol|mitochondrion
YDR068W	YDR068W	DOS2	hom	Verified	0.655831474093406	0.255966281479866	no	1242	0.228619114491843	789	NA					Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YLR012C_p	YLR012C	YLR012C	hom	Uncharacterized	0.655154788313199	0.256184050043242	no	1243	0.290394884606928	1013	NA					Putative protein of unknown function; YLR012C is not an essential gene	biological_process	molecular_function	cellular_component
YMR210W	YMR210W	YMR210W	hom	Verified	0.655123024347501	0.256194274580722	no	1244	0.221946419811913	712	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification	medium-chain fatty acid biosynthetic process	transferase activity, transferring acyl groups	cellular_component
YNL211C_p	YNL211C	YNL211C	hom	Uncharacterized	0.654791678808242	0.256300944441781	no	1245	0.251735619123257	871	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene	biological_process	molecular_function	mitochondrion
YDR244W	YDR244W	PEX5	hom	Verified	0.654556003810541	0.256376829232137	no	1246	0.276780046782958	928	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions	protein import into peroxisome matrix, docking	peroxisome matrix targeting signal-1 binding|protein binding, bridging	cytosol|peroxisomal membrane|peroxisome
YER076C_p	YER076C	YER076C	hom	Uncharacterized	0.653728531400727	0.25664335906017	no	1247	0.252640045619391	835	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization	biological_process	molecular_function	mitochondrion
YHR033W_p	YHR033W	YHR033W	hom	Uncharacterized	0.652639124125351	0.256994478315761	no	1248	0.226119715859929	756	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YBR097W	YBR097W	VPS15	hom	Verified	0.65183809462794	0.257252811876709	no	1249	0.252583860932553	832	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery	protein retention in Golgi apparatus|vacuole inheritance|peroxisome degradation|protein phosphorylation|macroautophagy|inositol lipid-mediated signaling|late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding|protein serine/threonine kinase activity	mitochondrion|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|Golgi membrane
YER066C-A_d	YER066C-A	YER066C-A	hom	Dubious	0.650806987436142	0.257585544542604	no	1250	0.238529937759524	819	NA					Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W	Unknown	Unknown	Unknown
YDL026W_d	YDL026W	YDL026W	hom	Dubious	0.649870197895062	0.257888035066448	no	1251	0.269013246279527	929	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR519W	YDR519W	FPR2	hom	Verified	0.649394079861163	0.258041844793098	no	1252	0.284028563496789	974	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress	biological_process	FK506 binding|peptidyl-prolyl cis-trans isomerase activity	endoplasmic reticulum membrane
YNL294C	YNL294C	RIM21	hom	Verified	0.648479088341937	0.25833756592791	no	1253	0.280017817907126	994	NA	FF|FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS	PLASMA MEMBRANE		pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH	fungal-type cell wall biogenesis|ascospore formation|invasive growth in response to glucose limitation	molecular_function	integral to membrane
YNR034W	YNR034W	SOL1	hom	Verified	0.648417584021365	0.258357450144282	no	1254	0.21022854233815	725	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	tRNA export from nucleus	molecular_function|6-phosphogluconolactonase activity	nucleus|cytoplasm
YFR024C-A	YFR024C-A	LSB3	hom	Verified	0.647624027208503	0.258614076486228	no	1255	0.241715466261713	825	NA	FT		MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication	actin cortical patch localization	molecular_function	mitochondrion|cellular bud neck|cytoplasm
YMR215W	YMR215W	GAS3	hom	Verified	0.647540058623097	0.258641238595512	no	1256	0.245329083784524	842	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation	biological_process	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane|plasma membrane
YML083C	YML083C	YML083C	hom	Verified	0.647453123906158	0.258669361743407	no	1257	0.236609629148931	801	NA					Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions	biological_process	molecular_function	cellular_component
YGL090W	YGL090W	LIF1	hom	Verified	0.646430916732997	0.259000161727921	no	1258	0.260830601634444	907	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein	double-strand break repair via nonhomologous end joining	chromatin binding	DNA ligase IV complex|nuclear chromatin|nucleus
YLL062C	YLL062C	MHT1	hom	Verified	0.645959949531887	0.259152646638998	no	1259	0.25559229505575	872	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio	sulfur amino acid metabolic process	homocysteine S-methyltransferase activity	cytoplasm
YKL008C	YKL008C	LAC1	hom	Verified	0.645874375650111	0.259180357850906	no	1260	0.252833584530593	849	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p	replicative cell aging|ceramide biosynthetic process	sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YNL264C	YNL264C	PDR17	hom	Verified	0.64474726283672	0.259545491343127	no	1261	0.26311701886636	919	NA	FT	LIPID METABOLISM			Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition	Golgi to plasma membrane protein transport|phosphatidylserine metabolic process|response to drug|sterol biosynthetic process|Unknown|phospholipid transport|phospholipid biosynthetic process	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	endosome|cell periphery|cytosol|cytoplasm
YDR286C_p	YDR286C	YDR286C	hom	Uncharacterized	0.644511366031114	0.259621944821801	no	1262	0.235648262440002	797	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site	biological_process	molecular_function	cellular_component
YFR020W_p	YFR020W	YFR020W	hom	Uncharacterized	0.644138095360995	0.259742944525611	no	1263	0.263248557309734	881	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YDR042C_p	YDR042C	YDR042C	hom	Uncharacterized	0.644068789995018	0.259765413808658	no	1264	0.235902020941478	771	NA					Putative protein of unknown function; expression is increased in ssu72-ts69 mutant	biological_process	molecular_function	cellular_component
YLR058C	YLR058C	SHM2	hom	Verified	0.643717500992469	0.259879319578488	no	1265	0.255403102897636	856	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	SITE OF POLARIZED GROWTH		Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis	one-carbon metabolic process	glycine hydroxymethyltransferase activity	plasma membrane|mating projection tip|cytoplasm
YBR144C_d	YBR144C	YBR144C	hom	Dubious	0.642764249042742	0.260188542138642	no	1266	0.235864776331059	805	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene	Unknown	Unknown	Unknown
YGR209C	YGR209C	TRX2	hom	Verified	0.642666634018726	0.260220217885774	no	1267	0.237066631573295	814	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress	vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|sulfate assimilation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic	disulfide oxidoreductase activity	cytosol|fungal-type vacuole
YEL066W	YEL066W	HPA3	hom	Verified	0.642087452886349	0.260408201084589	no	1268	0.206568755340938	720	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro	D-amino acid metabolic process	D-amino-acid N-acetyltransferase activity	nucleus|cytoplasm
YMR194W	YMR194W	RPL36A	hom	Verified	0.641556228741662	0.260580680495522	no	1269	0.245373026733351	827	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YOR003W	YOR003W	YSP3	hom	Verified	0.640426843447028	0.260947567949992	no	1270	0.245920386965301	824	NA	FT	PROTEOLYSIS			Putative precursor to the subtilisin-like protease III	protein catabolic process	peptidase activity	cellular_component
YHL025W	YHL025W	SNF6	hom	Verified	0.64034763253581	0.260973310045685	no	1271	0.275034336374157	885	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions	sucrose catabolic process|nucleotide-excision repair|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex|nucleus
YGR169C	YGR169C	PUS6	hom	Verified	0.63933681370431	0.261301922271948	no	1272	0.214698855795728	725	NA	FT	RNA PROCESSING	MITOCHONDRION		tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|cytoplasm
YNL293W	YNL293W	MSB3	hom	Verified	0.637764669520884	0.261813440678158	no	1273	0.260169039219242	899	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress	actin filament organization|exocytosis	Rab GTPase activator activity	incipient cellular bud site|polarisome|cellular bud tip
YJR074W	YJR074W	MOG1	hom	Verified	0.637703590033258	0.261833324076876	no	1274	0.261703028224864	906	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p	protein import into nucleus	Ran GTPase binding	nucleus
YDR296W	YDR296W	MHR1	hom	Verified	0.637553946520245	0.26188204127582	no	1275	0.2799950999593	955	NA	FT	MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress	cellular response to oxidative stress|positive regulation of mitochondrial DNA replication|regulation of transcription, DNA-dependent|mitochondrial genome maintenance|DNA recombination	single-stranded DNA binding|recombinase activity|DNA binding	mitochondrion|nucleus
YDR441C	YDR441C	APT2	hom	Verified	0.634741276390668	0.262798584211827	no	1276	0.256416575649164	868	NA					Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication	biological_process	adenine phosphoribosyltransferase activity|molecular_function	cytoplasm
YDL018C	YDL018C	ERP3	hom	Verified	0.634729423059442	0.262802450233276	no	1277	0.277399527489677	914	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YGR162W	YGR162W	TIF4631	hom	Verified	0.634334551189922	0.262931256230243	no	1278	0.269409648670169	950	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION	MITOCHONDRION	RIBOSOME	Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication	translational initiation|ribosomal large subunit biogenesis|stress granule assembly	translation initiation factor activity	mitochondrion|ribosome|eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YBR216C	YBR216C	YBP1	hom	Verified	0.633147243636786	0.263318746652364	no	1279	0.253693047260464	833	NA	FT	RESPONSE TO OXIDATIVE STRESS			Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication	cellular response to oxidative stress	molecular_function	cytoplasm
YDR332W	YDR332W	IRC3	hom	Verified	0.632871398481088	0.263408813373608	no	1280	0.263656197879676	907	NA	FT		MITOCHONDRION		Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	ATP-dependent RNA helicase activity	mitochondrion
YJL098W	YJL098W	SAP185	hom	Verified	0.632377220800672	0.263570207575539	no	1281	0.263958465823378	903	NA	FT	CELL CYCLE|RNA PROCESSING	MITOCHONDRION		Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication	tRNA wobble uridine modification|G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	mitochondrion|cytoplasm
YOR084W	YOR084W	LPX1	hom	Verified	0.629860804374967	0.264392829591371	no	1282	0.229704118886116	750	NA	FT	PEROXISOME ORGANIZATION			Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction	peroxisome organization	lipase activity	peroxisomal matrix
YCR094W	YCR094W	CDC50	hom	Verified	0.627255767686115	0.265245796347956	no	1283	0.309590968563277	1065	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	GOLGI APPARATUS		Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication	intracellular protein transport|phospholipid translocation|endocytosis|actin cortical patch localization	phospholipid-translocating ATPase activity	trans-Golgi network|late endosome membrane
YDR426C_d	YDR426C	YDR426C	hom	Dubious	0.627012497157349	0.26532552164721	no	1284	0.232052184220689	758	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41	Unknown	Unknown	Unknown
YMR244C-A	YMR244C-A	COA6	hom	Verified	0.626981920553859	0.265335543157798	no	1285	0.252185575110889	858	NA	FT		NUCLEUS|MITOCHONDRION		Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YDR476C_p	YDR476C	YDR476C	hom	Uncharacterized	0.624218868652003	0.266241928425258	no	1286	0.255129967068257	876	NA	FT		ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YJR144W	YJR144W	MGM101	hom	Verified	0.622981352292966	0.266648388047057	no	1287	0.289801116062994	1009	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	MITOCHONDRION|CHROMOSOME		Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage	DNA repair|recombinational repair|DNA strand renaturation	molecular_function	mitochondrial nucleoid|mitochondrion
YGL050W	YGL050W	TYW3	hom	Verified	0.622117203339082	0.266932401839056	no	1288	0.26576595525813	899	NA	FT	RNA PROCESSING			tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions	tRNA methylation|wybutosine biosynthetic process	tRNA methyltransferase activity	cellular_component
YJL042W	YJL042W	MHP1	hom	Verified	0.62027444082443	0.267538559638052	no	1289	0.252536663303215	845	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins	fungal-type cell wall organization|negative regulation of microtubule depolymerization	structural constituent of cytoskeleton	microtubule
YBR147W	YBR147W	RTC2	hom	Verified	0.620240415431546	0.267549758463741	no	1290	0.247113527441168	834	NA	FT		MITOCHONDRION		Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter	biological_process	molecular_function	mitochondrion|integral to membrane
YDR477W	YDR477W	SNF1	hom	Verified	0.619232431557435	0.267881624795949	no	1291	0.264574512239959	869	NA	FT	KETONE METABOLISM|SIGNALING|TRANSLATION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation	negative regulation of translation|protein phosphorylation|replicative cell aging|signal transduction|biofilm formation|positive regulation of gluconeogenesis|pseudohyphal growth|cell adhesion|regulation of carbohydrate metabolic process|invasive growth in response to glucose limitation|cellular response to nitrogen starvation	AMP-activated protein kinase activity|protein kinase activity	mitochondrion|AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|fungal-type vacuole|cytoplasm
YDR076W	YDR076W	RAD55	hom	Verified	0.617617992361679	0.268413590731556	no	1292	0.294829330633272	997	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p	DNA recombinase assembly|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|protein heterodimerization activity	nucleus|Rhp55-Rhp57 complex
YCL023C_d	YCL023C	YCL023C	hom	Dubious	0.617473694386233	0.268461163498165	no	1293	0.256688968542386	863	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4	Unknown	Unknown	Unknown
YNR007C	YNR007C	ATG3	hom	Verified	0.616906651495126	0.268648149648227	no	1294	0.274914496342845	922	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly	Atg8 ligase activity	cytosol|cytoplasm
YOR071C	YOR071C	NRT1	hom	Verified	0.61089130070033	0.270635772183499	no	1295	0.258573037976799	886	NA	FT		PLASMA MEMBRANE		High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity	thiamine transport|nicotinamide riboside transport	nicotinamide riboside transporter activity	integral to membrane|plasma membrane
YGR165W	YGR165W	MRPS35	hom	Verified	0.610776712792067	0.270673706064127	no	1296	0.306545831008722	1033	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YNR019W	YNR019W	ARE2	hom	Verified	0.609835377448789	0.270985431926217	no	1297	0.273457790725778	928	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication	ergosterol metabolic process	ergosterol O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YKL138C	YKL138C	MRPL31	hom	Verified	0.607471523468161	0.271769017611126	no	1298	0.282827669183697	970	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrial large ribosomal subunit
YMR305C	YMR305C	SCW10	hom	Verified	0.604797552512576	0.27265676003266	no	1299	0.275278335359916	910	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM		Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p	conjugation with cellular fusion	glucosidase activity	fungal-type cell wall|extracellular region|endoplasmic reticulum|cytoplasm
YMR267W	YMR267W	PPA2	hom	Verified	0.604507443313659	0.272753161029579	no	1300	0.293882332385796	1004	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate	aerobic respiration	inorganic diphosphatase activity	mitochondrion
YER032W	YER032W	FIR1	hom	Verified	0.604115342279892	0.272883479975879	no	1301	0.298411506118536	1000	NA	FT	RNA PROCESSING	SITE OF POLARIZED GROWTH		Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate	mRNA polyadenylation|RNA polyadenylation	molecular_function	cellular bud neck
YDR511W	YDR511W	ACN9	hom	Verified	0.604106305288258	0.272886483880127	no	1302	0.233438950310872	798	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes	carbon utilization|regulation of gluconeogenesis	molecular_function	mitochondrion|mitochondrial intermembrane space
YLR265C	YLR265C	NEJ1	hom	Verified	0.603574586993935	0.273063256388813	no	1303	0.259976744024368	870	NA	FT	RESPONSE TO DNA DAMAGE	ENDOMEMBRANE SYSTEM|NUCLEUS		Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p	double-strand break repair via nonhomologous end joining|double-strand break repair via single-strand annealing	DNA end binding	DNA ligase IV complex|nucleus
YDR463W	YDR463W	STP1	hom	Verified	0.602055413817939	0.273568625939857	no	1304	0.368967892438709	1188	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS|PLASMA MEMBRANE		Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication	positive regulation of transcription, DNA-dependent|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	plasma membrane|nucleus|cytoplasm
YMR035W	YMR035W	IMP2	hom	Verified	0.601901621933406	0.273619812279239	no	1305	0.242682251536763	823	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	protein processing involved in protein targeting to mitochondrion	endopeptidase activity	mitochondrial inner membrane peptidase complex
YGR138C	YGR138C	TPO2	hom	Verified	0.601854660370686	0.273635443375355	no	1306	0.222694657132048	745	NA	FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication	spermine transport	spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YCL040W	YCL040W	GLK1	hom	Verified	0.600915938037436	0.273947988555456	no	1307	0.279504334037853	953	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication	glucose import|mannose metabolic process|glycolysis|glucose metabolic process	glucokinase activity	cytosol|plasma membrane
YPR093C	YPR093C	ASR1	hom	Verified	0.60012143965507	0.274212652543579	no	1308	0.274004313909306	932	NA	FT		NUCLEUS		Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein	response to ethanol|protein ubiquitination	ubiquitin-protein ligase activity	nucleus|cytoplasm
YNL248C	YNL248C	RPA49	hom	Verified	0.599672075709404	0.274362400940259	no	1309	0.256447111937928	886	NA	FT		NUCLEUS		RNA polymerase I subunit A49	transcription elongation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size	molecular_function	DNA-directed RNA polymerase I complex
YMR031W-A_d	YMR031W-A	YMR031W-A	hom	Dubious	0.599578860517189	0.274393469514401	no	1310	0.273548753013689	922	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C	Unknown	Unknown	Unknown
YPL147W	YPL147W	PXA1	hom	Verified	0.598995112555385	0.274588071880605	no	1311	0.26618356530524	880	NA	FT	NUCLEOTIDE METABOLISM			Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder	fatty acid transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|integral to peroxisomal membrane
YDR109C_p	YDR109C	YDR109C	hom	Uncharacterized	0.597859530596688	0.274966832479439	no	1312	0.261091062166787	892	NA	FT	CARBOHYDRATE METABOLISM			Putative kinase	biological_process	molecular_function	cellular_component
YOL057W	YOL057W	YOL057W	hom	Verified	0.597844263121803	0.274971926527252	no	1313	0.262373620234612	881	NA	FT	PROTEOLYSIS	NUCLEUS		Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers	proteolysis	dipeptidyl-peptidase activity	nucleus|cytoplasm
YBR082C	YBR082C	UBC4	hom	Verified	0.59553407260683	0.275743265257712	no	1314	0.25065233333904	848	NA	FT	PROTEOLYSIS			Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress	ubiquitin binding|ubiquitin-protein ligase activity	proteasome complex
YPL253C	YPL253C	VIK1	hom	Verified	0.595083804002389	0.2758937270829	no	1315	0.279060573226403	966	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p	microtubule-based process|mitotic sister chromatid cohesion	microtubule motor activity	kinesin complex|spindle pole body
YMR143W	YMR143W	RPS16A	hom	Verified	0.59477365258642	0.275997390780769	no	1316	0.271154863777156	911	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YDL157C_p	YDL157C	YDL157C	hom	Uncharacterized	0.594505404600857	0.276087064276831	no	1317	0.232284808871099	770	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YMR269W	YMR269W	TMA23	hom	Verified	0.592631108874132	0.276714027566484	no	1318	0.276810233528954	959	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan	ribosomal small subunit biogenesis	molecular_function	ribosome|nucleolus
YCL005W-A	YCL005W-A	VMA9	hom	Verified	0.592434244976532	0.276779920196144	no	1319	0.307309443096675	1051	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis	cell wall mannoprotein biosynthetic process|vacuolar acidification|protein complex assembly|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions	vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane
YCR101C_p	YCR101C	YCR101C	hom	Uncharacterized	0.592384626867423	0.276796529165415	no	1320	0.277786828312016	979	NA					Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene	biological_process	molecular_function	integral to membrane|membrane
YOL039W	YOL039W	RPP2A	hom	Verified	0.59125505473471	0.277174769676749	no	1321	0.293913044271629	1000	NA	FT	TRANSLATION		RIBOSOME	Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	translational elongation|cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR272C	YBR272C	HSM3	hom	Verified	0.590740294545274	0.277347222459278	no	1322	0.266446456661273	912	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation	mismatch repair|proteasome regulatory particle assembly	molecular_function	cytosol|proteasome regulatory particle, base subcomplex|nucleus|cytoplasm
YDL243C	YDL243C	AAD4	hom	Verified	0.589442241137614	0.27778232364347	no	1323	0.271631565018521	932	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YDR461W	YDR461W	MFA1	hom	Verified	0.589361986519889	0.277809235537411	no	1324	0.282425037780243	958	NA	FT	SIGNALING	PLASMA MEMBRANE		Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YBR213W	YBR213W	MET8	hom	Verified	0.587724715063517	0.27835854180205	no	1325	0.300970444959705	1020	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis	siroheme biosynthetic process|sulfate assimilation	precorrin-2 dehydrogenase activity|ferrochelatase activity	cellular_component
YEL014C_d	YEL014C	YEL014C	hom	Dubious	0.586681031376059	0.278708974815493	no	1326	0.257000779682287	857	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL253W	YGL253W	HXK2	hom	Verified	0.58654290229584	0.278755369888961	no	1327	0.280900017721027	975	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication	replicative cell aging|fructose import|regulation of transcription by glucose|glucose import|mannose metabolic process|glycolysis|glucose metabolic process|regulation of cell size|fructose metabolic process	hexokinase activity	cytosol|mitochondrion|nucleus
YFL021W	YFL021W	GAT1	hom	Verified	0.586453994881106	0.278785234278816	no	1328	0.25018779972389	861	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p	nitrogen catabolite activation of transcription from RNA polymerase II promoter|nitrogen catabolite activation of transcription	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity	cytosol|nucleus
YLR399C	YLR399C	BDF1	hom	Verified	0.586377120354753	0.278811058024096	no	1329	0.246636546617465	871	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p	DNA repair|snRNA transcription|regulation of chromatin silencing at telomere|regulation of transcription by chromatin organization|regulation of chromatin silencing at silent mating-type cassette|Unknown|chromatin remodeling|negative regulation of heterochromatin assembly	histone acetyl-lysine binding|chromatin binding|core promoter binding|TFIID-class transcription factor binding	nuclear chromatin|Swr1 complex
YGR184C	YGR184C	UBR1	hom	Verified	0.586210565446041	0.278867011259962	no	1330	0.292642024480375	962	NA	FT	PROTEOLYSIS			E3 ubiquitin ligase (N-recognin); forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; plays a major role in targeting cytosolic misfolded proteins for degradation; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)	regulation of dipeptide transport|ubiquitin-dependent protein catabolic process via the N-end rule pathway|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	ubiquitin-protein ligase activity	proteasome regulatory particle, base subcomplex|cytoplasm
YNL276C_d	YNL276C	YNL276C	hom	Dubious	0.585945656247949	0.278956017351125	no	1331	0.282315290049086	978	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W	Unknown	Unknown	Unknown
YBL047C	YBL047C	EDE1	hom	Verified	0.585592210978989	0.279074791940369	no	1332	0.216482488852599	779	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING	SITE OF POLARIZED GROWTH|CYTOSKELETON		Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death	endoplasmic reticulum unfolded protein response|endocytosis	ubiquitin binding	cellular bud neck|mating projection tip|actin cortical patch|cellular bud tip
YBL022C	YBL022C	PIM1	hom	Verified	0.583978509805848	0.279617385277957	no	1333	0.3233491920812	1081	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria	chaperone-mediated protein complex assembly|misfolded or incompletely synthesized protein catabolic process	ATP-dependent peptidase activity	mitochondrion|mitochondrial matrix
YLR377C	YLR377C	FBP1	hom	Verified	0.583584465248291	0.279749957165141	no	1334	0.283333569907645	961	NA	FT	CARBOHYDRATE METABOLISM			Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p	gluconeogenesis|reactive oxygen species metabolic process	fructose 1,6-bisphosphate 1-phosphatase activity	cytosol
YNL035C	YNL035C	YNL035C	hom	Verified	0.582763790723263	0.280026161796816	no	1335	0.253488996462742	876	NA	FT		NUCLEUS		Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YLR017W	YLR017W	MEU1	hom	Verified	0.580459031617588	0.280802553250826	no	1336	0.262064498771229	888	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression	L-methionine salvage from methylthioadenosine|glutamate biosynthetic process	S-methyl-5-thioadenosine phosphorylase activity|mRNA binding	cytoplasm
YBR162C	YBR162C	TOS1	hom	Verified	0.58005557462094	0.280938570553008	no	1337	0.256959637087354	860	NA					Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C	biological_process	molecular_function	fungal-type cell wall|fungal-type vacuole
YIL107C	YIL107C	PFK26	hom	Verified	0.579781394186355	0.281031023067003	no	1338	0.287330609748764	983	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YDL233W_p	YDL233W	MFG1	hom	Uncharacterized	0.579298102468378	0.28119402282933	no	1339	0.272909632710229	920	NA	FT		NUCLEUS		Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YOR002W	YOR002W	ALG6	hom	Verified	0.579051164062036	0.281277325347237	no	1340	0.328557131909351	1144	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease	oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation|aerobic respiration	transferase activity, transferring hexosyl groups|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	integral to membrane|endoplasmic reticulum
YER092W	YER092W	IES5	hom	Verified	0.57876061817716	0.281375353720932	no	1341	0.286183505512336	987	NA	FT		NUCLEUS		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions	biological_process	molecular_function	nucleus
YGR058W	YGR058W	PEF1	hom	Verified	0.578699955257252	0.281395823093155	no	1342	0.269051310904206	938	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH		Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly	bipolar cellular bud site selection|regulation of COPII vesicle coating|axial cellular bud site selection	zinc ion binding|calcium ion binding	cytosol|site of polarized growth|nucleus|cellular bud neck|cytoplasm
YBL085W	YBL085W	BOI1	hom	Verified	0.57825929484303	0.281544535854049	no	1343	0.278564405658583	914	NA	FT	SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH		Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication	cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction	phospholipid binding	site of polarized growth|cellular bud|mating projection tip|cellular bud neck
YBL031W	YBL031W	SHE1	hom	Verified	0.576917285723156	0.281997666467344	no	1344	0.286108368328712	966	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function	mitotic spindle elongation	molecular_function	microtubule cytoskeleton|nuclear microtubule|cellular bud neck|astral microtubule|spindle
YEL057C_p	YEL057C	YEL057C	hom	Uncharacterized	0.576582477887493	0.282110769363853	no	1345	0.25639211753401	892	NA					Protein of unknown function involved in telomere maintenance; target of UME6 regulation	biological_process	molecular_function	cellular_component
YBR258C	YBR258C	SHG1	hom	Verified	0.576030586454423	0.282297253877058	no	1346	0.272082877480189	905	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres	histone H3-K4 methylation	histone methyltransferase activity (H3-K4 specific)	nucleus|Set1C/COMPASS complex
YAL008W	YAL008W	FUN14	hom	Verified	0.575321965326735	0.28253678440489	no	1347	0.299271491939662	1002	NA	FT		MITOCHONDRION		Mitochondrial protein of unknown function	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YDL129W	YDL129W	YDL129W	hom	Verified	0.574899872136209	0.282679508205412	no	1348	0.243523119498405	809	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YDL171C	YDL171C	GLT1	hom	Verified	0.573599150896484	0.283119543244575	no	1349	0.267932610835832	922	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source	glutamate biosynthetic process|ammonia assimilation cycle	glutamate synthase (NADH) activity	mitochondrion
YDL172C_d	YDL172C	YDL172C	hom	Dubious	0.572843792974215	0.283375232210523	no	1350	0.306169951886164	1025	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YFL046W_p	YFL046W	FMP32	hom	Uncharacterized	0.572392297907947	0.283528116322064	no	1351	0.281379837245963	933	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGL084C	YGL084C	GUP1	hom	Verified	0.572067720802949	0.283638048212004	no	1352	0.392421990421623	1307	NA	FF|FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport	GPI anchor biosynthetic process|glycerol transport|glycerol catabolic process	O-acyltransferase activity	integral to membrane|endoplasmic reticulum|plasma membrane|membrane
YOR161C-C_p	YOR161C-C	YOR161C-C	hom	Uncharacterized	0.572008428916548	0.28365813214538	no	1353	0.264830928613263	892	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YGR102C	YGR102C	GTF1	hom	Verified	0.571608763788054	0.283793528433321	no	1354	0.283574911539345	980	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria	glutaminyl-tRNAGln biosynthesis via transamidation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YGR189C	YGR189C	CRH1	hom	Verified	0.569947368001588	0.284356698104367	no	1355	0.268502009918302	915	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress	fungal-type cell wall organization|cell wall chitin metabolic process	transferase activity, transferring glycosyl groups	incipient cellular bud site|fungal-type cell wall
YIR032C	YIR032C	DAL3	hom	Verified	0.569616155540566	0.284469034272991	no	1356	0.291493304166674	1017	NA	FT		PLASMA MEMBRANE		Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression	allantoin catabolic process	ureidoglycolate hydrolase activity	membrane
YDR415C_p	YDR415C	YDR415C	hom	Uncharacterized	0.568925840901345	0.28470323398259	no	1357	0.258191088560181	878	NA	FT	PROTEOLYSIS			Putative aminopeptidase	biological_process	molecular_function	cellular_component
YOR034C-A_p	YOR034C-A	YOR034C-A	hom	Uncharacterized	0.568352384711943	0.284897857649236	no	1358	0.305517112279219	1012	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YML011C	YML011C	RAD33	hom	Verified	0.568166920335352	0.284960815456317	no	1359	0.26895203541679	904	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	nucleotide-excision repair	molecular_function	nucleus
YDR026C	YDR026C	NSI1	hom	Verified	0.567187202155834	0.285293501014829	no	1360	0.252935430956157	851	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication	termination of RNA polymerase I transcription|chromatin silencing at rDNA|Unknown	DNA binding	ribosome|nucleolus|rDNA heterochromatin
YMR133W	YMR133W	REC114	hom	Verified	0.566160220304441	0.285642434538599	no	1361	0.246049628311987	837	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YGR213C	YGR213C	RTA1	hom	Verified	0.565046318850321	0.286021129813487	no	1362	0.255293857820097	870	NA	FT		PLASMA MEMBRANE		Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein	biological_process	molecular_function	integral to membrane|plasma membrane
YML019W	YML019W	OST6	hom	Verified	0.562567523115003	0.286864706068257	no	1363	0.300697997220275	1028	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p	protein N-linked glycosylation via asparagine|protein complex assembly	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex|integral to membrane
YER041W	YER041W	YEN1	hom	Verified	0.561271289259245	0.287306305414379	no	1364	0.28227490317522	1015	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p	DNA repair|response to DNA damage stimulus	single-stranded DNA specific endodeoxyribonuclease activity|crossover junction endodeoxyribonuclease activity	nucleus|cytoplasm
YGR295C	YGR295C	COS6	hom	Verified	0.559510097654964	0.287906820894742	no	1365	0.269446367775887	891	NA					Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YFL004W	YFL004W	VTC2	hom	Verified	0.559427312296462	0.287935062890084	no	1366	0.281853900367721	970	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion	polyphosphate metabolic process|vacuolar transport|microautophagy|protein localization|vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex
YDL184C	YDL184C	RPL41A	hom	Verified	0.557631945245514	0.288547868925016	no	1367	0.280528747933449	917	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YML007C-A_p	YML007C-A	YML007C-A	hom	Uncharacterized	0.556505829477267	0.288932555216513	no	1368	0.306004062057586	1092	NA	FF|FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria	biological_process	molecular_function	mitochondrion
YIL043C	YIL043C	CBR1	hom	Verified	0.556457419683062	0.288949097632038	no	1369	0.299390756289855	997	NA	FT	OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia	biological_process	cytochrome-b5 reductase activity	mitochondrial outer membrane|mitochondrion
YDL134C	YDL134C	PPH21	hom	Verified	0.556279670952502	0.289009841091529	no	1370	0.268844539311494	905	NA	FT	CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION			Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication	actin filament organization|budding cell bud growth|protein dephosphorylation|G1/S transition of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|regulation of translation	protein serine/threonine phosphatase activity	protein phosphatase type 2A complex
YGL032C	YGL032C	AGA2	hom	Verified	0.556100521673678	0.28907106924896	no	1371	0.284697545986315	947	NA					Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YDR420W	YDR420W	HKR1	hom	Verified	0.555026715491525	0.289438193651337	no	1372	0.274402383533488	961	NA	FT	CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection	(1->3)-beta-D-glucan biosynthetic process|fungal-type cell wall organization|osmosensory signaling pathway via Sho1 osmosensor|hyperosmotic response|cellular bud site selection	osmosensor activity	site of polarized growth|plasma membrane
YBR084C-A	YBR084C-A	RPL19A	hom	Verified	0.554998382790955	0.289447883304546	no	1373	0.27360149204544	937	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YNL027W	YNL027W	CRZ1	hom	Verified	0.554166659885261	0.289732396575668	no	1374	0.277625156537996	926	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS	NUCLEUS		Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress	regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to calcium ion|positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cell wall chitin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter by pheromones|ion homeostasis|Unknown|positive regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YGR025W_d	YGR025W	YGR025W	hom	Dubious	0.553264756661153	0.290041065149432	no	1375	0.263014509911603	893	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL069C	YPL069C	BTS1	hom	Verified	0.553135640510799	0.290085266645052	no	1376	0.364697834005902	1246	NA	FF|FT	PROTEIN LOCALIZATION|LIPID METABOLISM	MITOCHONDRION		Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic	terpenoid biosynthetic process	farnesyltranstransferase activity	mitochondrion
YDL161W	YDL161W	ENT1	hom	Verified	0.551079984380005	0.290789422831386	no	1377	0.268586268262245	912	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress	actin filament organization|endocytosis|actin cortical patch assembly	clathrin binding	mating projection tip|actin cortical patch
YGR263C	YGR263C	SAY1	hom	Verified	0.550642615194512	0.29093934481236	no	1378	0.304185263238293	1016	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum	response to toxin|sterol metabolic process|sterol deacetylation	steryl deacetylase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YDR144C	YDR144C	MKC7	hom	Verified	0.549082844422861	0.291474298957634	no	1379	0.298459848729889	1019	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	PLASMA MEMBRANE		GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p	proteolysis|fungal-type cell wall organization	aspartic-type endopeptidase activity	fungal-type cell wall
YNL269W	YNL269W	BSC4	hom	Verified	0.548400219715818	0.29170856280899	no	1380	0.28876866715073	999	NA					Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p	biological_process	molecular_function	cellular_component
YBR191W	YBR191W	RPL21A	hom	Verified	0.548198617041246	0.291777765804012	no	1381	0.301791371001932	1025	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YKL187C	YKL187C	FAT3	hom	Verified	0.547396275459254	0.292053256775548	no	1382	0.267075294711191	889	NA	FT		MITOCHONDRION		Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|integral to membrane
YCR087C-A_p	YCR087C-A	YCR087C-A	hom	Uncharacterized	0.546981370096917	0.292195765626475	no	1383	0.303827426695697	1040	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene	biological_process	molecular_function	nucleolus
YGR066C_p	YGR066C	YGR066C	hom	Uncharacterized	0.546750854791518	0.292274955422612	no	1384	0.31119134859405	1027	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL247C_p	YPL247C	YPL247C	hom	Uncharacterized	0.545497943759547	0.292705547178675	no	1385	0.284053692605007	966	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest	biological_process	molecular_function	nucleus|cytoplasm
YGR192C	YGR192C	TDH3	hom	Verified	0.545104589385585	0.292840793219879	no	1386	0.298280442287417	988	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication	gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YNR014W_p	YNR014W	YNR014W	hom	Uncharacterized	0.545052389323043	0.292858743215661	no	1387	0.305737082062245	1038	NA					Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YGL004C	YGL004C	RPN14	hom	Verified	0.544358503624461	0.293097397665337	no	1388	0.311056727374339	1040	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p	proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|cytoplasm
YER137C_p	YER137C	YER137C	hom	Uncharacterized	0.543680608138971	0.293330639525021	no	1389	0.299344174177753	1007	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR308C	YOR308C	SNU66	hom	Verified	0.541058716384232	0.29423355615121	no	1390	0.294144127814914	1037	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1	maturation of 5S rRNA|mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YDR252W	YDR252W	BTT1	hom	Verified	0.539417979985536	0.294799238723519	no	1391	0.292314198600491	980	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3	'de novo' cotranslational protein folding	unfolded protein binding	nascent polypeptide-associated complex|CCR4-NOT complex
YNL012W	YNL012W	SPO1	hom	Verified	0.538531281570084	0.295105157471313	no	1392	0.267168962289514	935	NA	FT	CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B	meiosis|spore membrane bending pathway	phospholipase activity	endoplasmic reticulum|nucleus|prospore membrane
YJR088C	YJR088C	EMC2	hom	Verified	0.537689841604416	0.295395596777778	no	1393	0.273341923910516	951	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YDR114C_p	YDR114C	YDR114C	hom	Uncharacterized	0.537457371417462	0.295475861545186	no	1394	0.312136299140265	1058	NA					Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium	biological_process	molecular_function	cellular_component
YDR250C_d	YDR250C	YDR250C	hom	Dubious	0.536331034814335	0.295864892702988	no	1395	0.297080690894118	1025	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR419W	YDR419W	RAD30	hom	Verified	0.534145630178193	0.296620391029826	no	1396	0.264788811087866	877	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV	error-prone translesion synthesis|error-free translesion synthesis	DNA-directed DNA polymerase activity	replication fork
YDR514C	YDR514C	YDR514C	hom	Verified	0.532913243653816	0.297046818555199	no	1397	0.28955943418579	977	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|nucleus
YGL262W_p	YGL262W	YGL262W	hom	Uncharacterized	0.532007103140637	0.297360537940822	no	1398	0.274086865315813	929	NA					Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene	biological_process	molecular_function	cellular_component
YNL143C_p	YNL143C	YNL143C	hom	Uncharacterized	0.532000260369854	0.297362907586031	no	1399	0.311699196484568	1055	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YOR154W_p	YOR154W	SLP1	hom	Uncharacterized	0.530280881021181	0.297958600259982	no	1400	0.269719447486214	929	NA					Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p	protein folding in endoplasmic reticulum	molecular_function	cellular_component
YBR296C	YBR296C	PHO89	hom	Verified	0.529188617221546	0.298337306071482	no	1401	0.305176234954666	1063	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification	phosphate ion transport|transmembrane transport	sodium:inorganic phosphate symporter activity	integral to membrane|plasma membrane
YPR166C	YPR166C	MRP2	hom	Verified	0.529068652624657	0.298378913119796	no	1402	0.318600546146447	1047	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YGR177C	YGR177C	ATF2	hom	Verified	0.527204064393622	0.2990259432586	no	1403	0.285572324036602	958	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking	steroid metabolic process|response to toxin|Unknown|sterol acetylation	alcohol O-acetyltransferase activity	integral to endoplasmic reticulum membrane|endoplasmic reticulum|cytoplasm
YEL007W	YEL007W	MIT1	hom	Verified	0.527153447913739	0.299043516545493	no	1404	0.27698564279135	953	NA	FT		NUCLEUS		Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1	biological_process	molecular_function	nucleus|cytoplasm
YLL045C	YLL045C	RPL8B	hom	Verified	0.526987528172649	0.299101124692588	no	1405	0.275041745127818	946	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR217W	YBR217W	ATG12	hom	Verified	0.525900938132738	0.299478518541311	no	1406	0.300691858610738	1023	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly	Atg8 ligase activity|protein tag	Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YKL074C	YKL074C	MUD2	hom	Verified	0.525872126010816	0.299488528488757	no	1407	0.265721930689241	914	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65	mRNA branch site recognition	pre-mRNA branch point binding	commitment complex
YDR471W	YDR471W	RPL27B	hom	Verified	0.525261799147049	0.29970060472085	no	1408	0.295516364031047	1002	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YEL067C_p	YEL067C	YEL067C	hom	Uncharacterized	0.525136605133613	0.29974411551318	no	1409	0.306600892763199	1014	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGL067W	YGL067W	NPY1	hom	Verified	0.524769521283972	0.29987171085939	no	1410	0.250740189954943	834	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member	NADH metabolic process	NAD+ diphosphatase activity	peroxisome|cytoplasm
YOL075C_p	YOL075C	YOL075C	hom	Uncharacterized	0.524707282645814	0.299893346938936	no	1411	0.265940952876305	881	NA	FT	NUCLEOTIDE METABOLISM			Putative ABC transporter	transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YOR155C	YOR155C	ISN1	hom	Verified	0.523552180822322	0.300295024313902	no	1412	0.299571458979215	993	NA	FT	NUCLEOTIDE METABOLISM			Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms	nicotinamide riboside biosynthetic process|inosine salvage|nicotinic acid riboside biosynthetic process	IMP 5'-nucleotidase activity	cellular_component
YDR289C	YDR289C	RTT103	hom	Verified	0.523428100219389	0.30033818680605	no	1413	0.316404874206338	1094	NA	FT	RNA PROCESSING	NUCLEUS|CHROMOSOME		Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition	negative regulation of transposition, RNA-mediated|mRNA 3'-end processing	RNA polymerase II core binding	nuclear chromatin|site of double-strand break
YNL144C_p	YNL144C	YNL144C	hom	Uncharacterized	0.522958441428433	0.300501586991141	no	1414	0.295319673739335	980	NA	FT		MITOCHONDRION		Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study	biological_process	molecular_function	mitochondrion
YAL031C	YAL031C	GIP4	hom	Verified	0.522639802825357	0.300612468213275	no	1415	0.290532453816042	986	NA	FT	CHROMOSOME SEGREGATION			Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate	chromosome segregation|regulation of phosphoprotein phosphatase activity	protein phosphatase 1 binding|protein phosphatase type 1 regulator activity	cytoplasm
YOR052C	YOR052C	YOR052C	hom	Verified	0.522359973751015	0.300709859560169	no	1416	0.301004321637782	1015	NA	FT		NUCLEUS		Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YOL043C	YOL043C	NTG2	hom	Verified	0.521884651760837	0.300875322634426	no	1417	0.273176416554492	911	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication	base-excision repair|base-excision repair, AP site formation	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity	nucleus
YJR048W	YJR048W	CYC1	hom	Verified	0.521125471861694	0.30113968386226	no	1418	0.272343919584312	903	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c	electron carrier activity	mitochondrion|mitochondrial intermembrane space
YOR339C	YOR339C	UBC11	hom	Verified	0.521122469431632	0.301140729574635	no	1419	0.290881045479312	964	NA					Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2	protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YOL121C	YOL121C	RPS19A	hom	Verified	0.521065792911286	0.301160469671512	no	1420	0.306834500839463	1031	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit biogenesis|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YBR172C	YBR172C	SMY2	hom	Verified	0.520645570705426	0.301306848763018	no	1421	0.275779284490301	915	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport	molecular_function	endoplasmic reticulum membrane|cytoplasmic mRNA processing body|cytoplasm|extrinsic to membrane
YML103C	YML103C	NUP188	hom	Verified	0.519654640507749	0.301652153549591	no	1422	0.28063371191327	960	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188	nuclear pore organization|protein import into nucleus|mRNA export from nucleus in response to heat stress	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YBR037C	YBR037C	SCO1	hom	Verified	0.517763457877233	0.302311658489034	no	1423	0.313597021792265	1059	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication	copper ion transport|response to redox state|protein complex assembly	copper ion binding|thioredoxin peroxidase activity	mitochondrion|mitochondrial inner membrane
YIL036W	YIL036W	CST6	hom	Verified	0.517581540942576	0.3023751317822	no	1424	0.227260677086733	819	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication	cellular response to carbon dioxide|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|DNA metabolic process	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YKL179C	YKL179C	COY1	hom	Verified	0.515853961231112	0.302978205508896	no	1425	0.21710754558168	712	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function	Golgi vesicle transport	molecular_function	Golgi membrane
YKL157W	YKL157W	APE2	hom	Verified	0.515232096134311	0.303195421526409	no	1426	0.311383771108686	1027	NA	FT	PROTEOLYSIS	MITOCHONDRION		Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication	peptide catabolic process	metalloaminopeptidase activity	mitochondrion|extracellular region|cell wall-bounded periplasmic space
YKL143W	YKL143W	LTV1	hom	Verified	0.514299536780077	0.303521292760996	no	1427	0.275782916132597	935	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature	ribosomal small subunit biogenesis|cellular response to oxidative stress|response to osmotic stress|ribosomal small subunit export from nucleus	molecular_function	preribosome, small subunit precursor|EGO complex|nucleus|late endosome membrane|cytoplasm
YDL174C	YDL174C	DLD1	hom	Verified	0.513531060915733	0.303789944566495	no	1428	0.282984925871417	986	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane	cellular carbohydrate metabolic process|aerobic respiration	D-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial inner membrane
YDR440W	YDR440W	DOT1	hom	Verified	0.513433235599024	0.30382415097172	no	1429	0.307510520960346	1061	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS		Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response	meiotic recombination checkpoint|postreplication repair|recombinational repair|global genome nucleotide-excision repair|nucleotide-excision repair|DNA damage checkpoint|chromatin silencing at telomere|histone H3-K79 methylation	nucleosomal histone binding|histone methyltransferase activity (H3-K79 specific)	nucleus
YPR051W	YPR051W	MAK3	hom	Verified	0.513217772022041	0.303899497798256	no	1430	0.335768679445528	1144	NA	FT		NUCLEUS		Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex
YHL037C_d	YHL037C	YHL037C	hom	Dubious	0.512101215822663	0.304290086837015	no	1431	0.29053459196808	951	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL009C	YGL009C	LEU1	hom	Verified	0.510795094304264	0.304747272310394	no	1432	0.303726440191959	1046	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway	leucine biosynthetic process	3-isopropylmalate dehydratase activity	cytosol
YDR283C	YDR283C	GCN2	hom	Verified	0.51074520186206	0.304764742359361	no	1433	0.354129070464338	1205	NA	FF|FT	KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION		RIBOSOME	Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control	cellular amino acid biosynthetic process|protein phosphorylation|regulation of translational initiation|DNA damage checkpoint	protein homodimerization activity|protein kinase activity|eukaryotic translation initiation factor 2alpha kinase activity	cytosolic ribosome
YDR239C	YDR239C	YDR239C	hom	Verified	0.510662626841663	0.304793657328977	no	1434	0.307310360184751	1051	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments	biological_process	molecular_function	ribosome|cytoplasm
YMR095C	YMR095C	SNO1	hom	Verified	0.510652519203606	0.304797196764543	no	1435	0.278615199792839	935	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase	pyridoxine metabolic process|thiamine biosynthetic process|anti-apoptosis	molecular_function	cytoplasm
YFL001W	YFL001W	DEG1	hom	Verified	0.510124014092417	0.304982291141962	no	1436	0.328797339565129	1106	NA	FT	RNA PROCESSING	NUCLEUS		tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability	tRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus|cytoplasm
YLR251W	YLR251W	SYM1	hom	Verified	0.509928921250824	0.305050629657364	no	1437	0.295292496213109	995	NA	FT		MITOCHONDRION		Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17	ethanol metabolic process	molecular_function	mitochondrion|integral to membrane|mitochondrial inner membrane
YNR040W_p	YNR040W	YNR040W	hom	Uncharacterized	0.509867131179578	0.305072275343074	no	1438	0.310698801278674	1050	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGL222C	YGL222C	EDC1	hom	Verified	0.509415098778084	0.305230647595418	no	1439	0.297206064171207	1010	NA	FT	RNA PROCESSING|TRANSLATION	NUCLEUS		RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of translation in response to stress	mRNA binding	nucleus|cytoplasm
YOR019W	YOR019W	YOR019W	hom	Verified	0.509257558386092	0.305285851384885	no	1440	0.300014423057756	1011	NA	FT	CELL CYCLE			Protein of unknown function that may interact with ribosomes, based on co-purification experiments	mitochondrion degradation	molecular_function	ribosome
YOR318C_d	YOR318C	YOR318C	hom	Dubious	0.509107001925783	0.305338612071109	no	1441	0.301761765554323	1021	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo	Unknown	Unknown	Unknown
YOL038C-A_p	YOL038C-A	YOL038C-A	hom	Uncharacterized	0.508910566256331	0.305407456650423	no	1442	0.279970401116459	922	NA					Putative protein of unknown function; identified by SAGE analysis	biological_process	molecular_function	cellular_component
YEL068C_p	YEL068C	YEL068C	hom	Uncharacterized	0.507367155263126	0.305948613422545	no	1443	0.272116621075475	898	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YDR528W	YDR528W	HLR1	hom	Verified	0.505711229507349	0.306529691949284	no	1444	0.286484802016867	945	NA	FT	CELL WALL ORG/BIOGENESIS			Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A; <br>HLR1 has a paralog, LRE1, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cytoplasm
YBR108W	YBR108W	AIM3	hom	Verified	0.505700946056477	0.306533302022433	no	1445	0.30478096872869	1028	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss	actin cortical patch assembly	molecular_function	membrane raft|actin cortical patch
YGL249W	YGL249W	ZIP2	hom	Verified	0.503650141673082	0.307253625230382	no	1446	0.27327510197825	914	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	synaptonemal complex assembly|synapsis|reciprocal meiotic recombination	molecular_function	synaptonemal complex
YBR176W	YBR176W	ECM31	hom	Verified	0.502963444602047	0.307494986737343	no	1447	0.317912484328594	1047	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate	pantothenate biosynthetic process	3-methyl-2-oxobutanoate hydroxymethyltransferase activity	mitochondrion
YJL121C	YJL121C	RPE1	hom	Verified	0.502848877891577	0.307535262966206	no	1448	0.329806395737812	1131	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress	pentose-phosphate shunt	ribulose-phosphate 3-epimerase activity	cytosol
YER053C	YER053C	PIC2	hom	Verified	0.502049043669267	0.307816511418868	no	1449	0.268950367526999	892	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature	phosphate ion transport|transmembrane transport	inorganic phosphate transmembrane transporter activity	mitochondrion|integral to membrane
YDR161W_p	YDR161W	YDR161W	hom	Uncharacterized	0.501905632444069	0.30786695154674	no	1450	0.311967829684812	1056	NA	FT	PROTEOLYSIS	NUCLEUS		Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD)	ER-associated protein catabolic process	molecular_function	nucleus|cytoplasm
YEL025C_p	YEL025C	YEL025C	hom	Uncharacterized	0.500117515047995	0.308496166967773	no	1451	0.274829316520108	927	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YBR113W_d	YBR113W	YBR113W	hom	Dubious	0.496080903049481	0.309918666091765	no	1452	0.278010484294312	923	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8	Unknown	Unknown	Unknown
YBR221C	YBR221C	PDB1	hom	Verified	0.495895143624364	0.309984196339219	no	1453	0.286373330018235	1003	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria	acetyl-CoA biosynthetic process from pyruvate	pyruvate dehydrogenase (acetyl-transferring) activity	mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YDR290W_d	YDR290W	YDR290W	hom	Dubious	0.495662863863135	0.310066146032907	no	1454	0.3353884378073	1131	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103	Unknown	Unknown	Unknown
YOR124C	YOR124C	UBP2	hom	Verified	0.495118526676164	0.310258228418347	no	1455	0.297971433844769	1025	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity	protein deubiquitination|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ubiquitin-specific protease activity	cytoplasm
YOR357C	YOR357C	SNX3	hom	Verified	0.494968431207652	0.310311202299914	no	1456	0.31105374927008	1053	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p	protein localization|late endosome to Golgi transport	phosphatidylinositol-3-phosphate binding	cytosol|endosome
YJR092W	YJR092W	BUD4	hom	Verified	0.494840168782828	0.310356473663957	no	1457	0.301021932182507	1018	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p	cellular bud site selection|axial cellular bud site selection	GTP binding	cellular bud neck contractile ring
YDL131W	YDL131W	LYS21	hom	Verified	0.494740726659464	0.310391574623697	no	1458	0.283164358291337	975	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication	lysine biosynthetic process via aminoadipic acid	homocitrate synthase activity	nucleus
YOL032W	YOL032W	OPI10	hom	Verified	0.494533918482199	0.310464579052567	no	1459	0.275084915447152	940	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	NUCLEUS		Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress	inositol metabolic process	molecular_function	nucleus|cytoplasm
YDL040C	YDL040C	NAT1	hom	Verified	0.493663003773137	0.310772098659413	no	1460	0.294151174471493	1014	NA	FT		MITOCHONDRION	RIBOSOME	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	mitochondrion|NatA complex|cytosolic ribosome
YPR164W	YPR164W	MMS1	hom	Verified	0.493499876042752	0.310829713700464	no	1461	0.314677601684932	1089	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay	replication fork processing|negative regulation of transposition, RNA-mediated|recombinational repair|nonfunctional rRNA decay	molecular_function	Cul8-RING ubiquitin ligase complex
YPL103C	YPL103C	FMP30	hom	Verified	0.493274815847556	0.310909210266742	no	1462	0.319364280976274	1067	NA	FT	LIPID METABOLISM	MITOCHONDRION		Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D	N-acylphosphatidylethanolamine metabolic process|N-acylethanolamine metabolic process	NAPE-specific phospholipase D activity	mitochondrion|integral to mitochondrial inner membrane
YNL123W	YNL123W	NMA111	hom	Verified	0.493265836916664	0.310912382019895	no	1463	0.351872759284642	1182	NA	FT	LIPID METABOLISM|PROTEOLYSIS	NUCLEUS		Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases	apoptotic process|cellular lipid metabolic process|protein catabolic process|cellular response to heat	serine-type peptidase activity	nucleus
YNR006W	YNR006W	VPS27	hom	Verified	0.492892740187861	0.311044188604855	no	1464	0.341827831151167	1141	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)	protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding|phosphatidylinositol-3-phosphate binding	endosome|ESCRT-0 complex
YJR094W-A	YJR094W-A	RPL43B	hom	Verified	0.492700233710587	0.311112206244508	no	1465	0.290885281780746	1013	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGL101W_p	YGL101W	YGL101W	hom	Uncharacterized	0.491999661178776	0.311359791532169	no	1466	0.31104664181113	1020	NA	FT		NUCLEUS		Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p	biological_process	molecular_function	nucleus|cytoplasm
YBR181C	YBR181C	RPS6B	hom	Verified	0.491959199158147	0.311374093588964	no	1467	0.315784329739907	1058	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|cytoplasm
YGL141W	YGL141W	HUL5	hom	Verified	0.491918887635447	0.311388342732564	no	1468	0.326075248812916	1096	NA	FT	PROTEOLYSIS	NUCLEUS		Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD	ER-associated protein catabolic process|protein polyubiquitination	ubiquitin-ubiquitin ligase activity	proteasome complex|nucleus|cytoplasm
YHL045W_d	YHL045W	YHL045W	hom	Dubious	0.489636676844867	0.312195509084629	no	1469	0.306558584335043	1055	NA					Putative protein of unknown function; not an essential gene	Unknown	Unknown	Unknown
YGR176W_d	YGR176W	YGR176W	hom	Dubious	0.489324681149917	0.312305925099509	no	1470	0.297200423443244	997	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL136W-A_p	YJL136W-A	YJL136W-A	hom	Uncharacterized	0.488988553905362	0.312424900191152	no	1471	0.286868987135199	946	NA					Putative protein of unknown function; identified by SAGE	biological_process	molecular_function	cellular_component
YEL039C	YEL039C	CYC7	hom	Verified	0.487473392402824	0.312961447085928	no	1472	0.328131751527025	1083	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c	electron carrier activity	mitochondrion|mitochondrial intermembrane space
YPL119C	YPL119C	DBP1	hom	Verified	0.486595976060628	0.313272337867166	no	1473	0.30200222429153	1005	NA	FT	TRANSLATION			Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress	translational initiation	RNA helicase activity	cytoplasm
YDR031W	YDR031W	MIC14	hom	Verified	0.486430272699407	0.313331065664568	no	1474	0.296886408323541	939	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	aerobic respiration	molecular_function	nucleus|mitochondrial intermembrane space|cytoplasm
YJL135W_d	YJL135W	YJL135W	hom	Dubious	0.485481263815479	0.313667500034833	no	1475	0.299805406009266	987	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3	Unknown	Unknown	Unknown
YDR273W	YDR273W	DON1	hom	Verified	0.484534287711211	0.314003368303895	no	1476	0.290159348441659	1024	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION			Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II	meiosis|ascospore wall assembly	molecular_function	prospore membrane
YDR417C_d	YDR417C	YDR417C	hom	Dubious	0.484494651779322	0.314017429520454	no	1477	0.318882094359597	1082	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W	Unknown	Unknown	Unknown
YNL078W	YNL078W	NIS1	hom	Verified	0.483990518004377	0.314196299232921	no	1478	0.280078667040986	985	NA	FT	CELL CYCLE	NUCLEUS|SITE OF POLARIZED GROWTH		Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network	regulation of mitosis	molecular_function	nucleus|cellular bud neck
YEL045C_d	YEL045C	YEL045C	hom	Dubious	0.482234554852878	0.31481966614945	no	1479	0.343960027960184	1126	NA					Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress	Unknown	Unknown	Unknown
YKL156W	YKL156W	RPS27A	hom	Verified	0.482029096242763	0.314892638493436	no	1480	0.325799465335868	1082	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasm
YPL032C	YPL032C	SVL3	hom	Verified	0.481922611072489	0.314930461472659	no	1481	0.348126129720616	1167	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS	SITE OF POLARIZED GROWTH		Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress	endocytosis	molecular_function	cellular bud|cellular bud neck|cytoplasm
YOR087W	YOR087W	YVC1	hom	Verified	0.481150319960047	0.315204833330443	no	1482	0.310102253338815	1028	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock	cellular cation homeostasis	voltage-gated ion channel activity|calcium activated cation channel activity|sodium channel activity|calcium channel activity|potassium channel activity	fungal-type vacuole membrane|fungal-type vacuole
YDL137W	YDL137W	ARF2	hom	Verified	0.48005436144812	0.315594369505285	no	1483	0.320577863889459	1090	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport	GTPase activity	cytosol|Golgi-associated vesicle
YKL204W	YKL204W	EAP1	hom	Verified	0.479379624877014	0.31583429288114	no	1484	0.339723243217182	1165	NA	FT	TRANSLATION			eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade	negative regulation of translation	eukaryotic initiation factor 4E binding	mRNA cap binding complex|cytoplasmic stress granule
YHR003C	YHR003C	YHR003C	hom	Verified	0.478659503523075	0.316090439836371	no	1485	0.279710171452937	962	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YDR421W	YDR421W	ARO80	hom	Verified	0.478610153435259	0.316107996882576	no	1486	0.286489160194814	983	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids	aromatic amino acid family catabolic process|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|nucleic acid binding transcription factor activity	nucleus
YBL071C-B_p	YBL071C-B	YBL071C-B	hom	Uncharacterized	0.478006454038079	0.316322805703089	no	1487	0.329572033467351	1118	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YMR322C_p	YMR322C	SNO4	hom	Uncharacterized	0.477377351540041	0.316546719439966	no	1488	0.287621464858004	937	NA	FT	PROTEOLYSIS			Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation	biological_process	cysteine-type peptidase activity	cellular_component
YFR018C_p	YFR018C	YFR018C	hom	Uncharacterized	0.477268490399337	0.316585472743805	no	1489	0.306361750269585	1042	NA	FT	PROTEOLYSIS			Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKR020W	YKR020W	VPS51	hom	Verified	0.476863005633357	0.31672983833384	no	1490	0.343579325785045	1150	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL DIVISION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p	vesicle organization|retrograde transport, endosome to Golgi|budding cell apical bud growth|regulation of cell size|protein targeting to vacuole	protein binding	Golgi apparatus|GARP complex
YMR001C-A_p	YMR001C-A	YMR001C-A	hom	Uncharacterized	0.474624720741674	0.317527241473117	no	1491	0.309165910981683	1045	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR044C	YLR044C	PDC1	hom	Verified	0.473863866492489	0.317798493787532	no	1492	0.329397078408548	1110	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism	L-phenylalanine catabolic process|pyruvate metabolic process|glucose catabolic process to ethanol|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	pyruvate decarboxylase activity	cytosol|nucleus|cytoplasm
YFR012W	YFR012W	DCV1	hom	Verified	0.472511927129934	0.318280715223976	no	1493	0.305832426965231	1024	NA					Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YIL095W	YIL095W	PRK1	hom	Verified	0.47159403748545	0.318608291719157	no	1494	0.310509769202636	1047	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication	regulation of endocytosis|actin filament organization|protein phosphorylation|actin cortical patch assembly|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	mating projection tip|actin cortical patch
YER093C-A	YER093C-A	AIM11	hom	Verified	0.47119271775662	0.318751559295021	no	1495	0.316081365487605	1079	NA					Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YBR250W	YBR250W	SPO23	hom	Verified	0.470546170025951	0.318982428066779	no	1496	0.323362209333195	1079	NA	FT	CELL CYCLE			Protein of unknown function; associates with meiosis-specific protein Spo1p	meiosis	molecular_function	cellular_component
YDR503C	YDR503C	LPP1	hom	Verified	0.470465307856712	0.319011307212472	no	1497	0.305057218621074	1019	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA	phospholipid metabolic process	phosphatidate phosphatase activity	integral to membrane|membrane
YPR091C	YPR091C	NVJ2	hom	Verified	0.470047524504547	0.319160532015571	no	1498	0.300589447923524	1021	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments	biological_process	lipid binding	ribosome|nucleus-vacuole junction|endoplasmic reticulum
YGL216W	YGL216W	KIP3	hom	Verified	0.46966371629148	0.319297647331335	no	1499	0.290780064788262	1004	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Kinesin-related motor protein involved in mitotic spindle positioning	nuclear migration along microtubule|mitotic spindle disassembly|establishment of mitotic spindle orientation|plus-end specific microtubule depolymerization|mitotic spindle organization in nucleus	plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity	kinesin complex|cytoplasmic microtubule|nuclear microtubule
YPR024W	YPR024W	YME1	hom	Verified	0.467964549307011	0.319904970728196	no	1500	0.292743209867386	993	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover	chronological cell aging|misfolded or incompletely synthesized protein catabolic process|mitochondrion organization	ATP-dependent peptidase activity	mitochondrion|mitochondrial inner membrane|i-AAA complex
YHR007C-A_p	YHR007C-A	YHR007C-A	hom	Uncharacterized	0.465596067597367	0.320752329136799	no	1501	0.301301237588142	1018	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YNL278W	YNL278W	CAF120	hom	Verified	0.465411181566131	0.32081851416262	no	1502	0.309108651754712	1021	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|SITE OF POLARIZED GROWTH		Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter	molecular_function	CCR4-NOT complex
YGL053W	YGL053W	PRM8	hom	Verified	0.465317997315416	0.320851874179705	no	1503	0.310959757403895	1046	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family	biological_process	molecular_function	integral to membrane|endoplasmic reticulum|plasma membrane
YDR169C	YDR169C	STB3	hom	Verified	0.464161452585144	0.321266038198209	no	1504	0.306751299296534	1040	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter by glucose	sequence-specific DNA binding	nucleus|cytoplasm
YPR073C	YPR073C	LTP1	hom	Verified	0.463469225333433	0.321514034396588	no	1505	0.305792429097043	1042	NA	FT		NUCLEUS		Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine	protein dephosphorylation	protein tyrosine phosphatase activity	nucleus|cytoplasm
YIL012W_d	YIL012W	YIL012W	hom	Dubious	0.463227837704625	0.321600532249666	no	1506	0.324213410852351	1083	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL201W	YDL201W	TRM8	hom	Verified	0.463137984109505	0.321632732489054	no	1507	0.304872434763601	1027	NA	FT	RNA PROCESSING	NUCLEUS		Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p	tRNA methylation	tRNA (guanine-N7-)-methyltransferase activity	tRNA methyltransferase complex|nucleus
YNL092W_p	YNL092W	YNL092W	hom	Uncharacterized	0.462479111507366	0.321868889237401	no	1508	0.307082726234173	1026	NA					Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YHR086W	YHR086W	NAM8	hom	Verified	0.462003561787381	0.322039383112489	no	1509	0.327711049779949	1054	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS|MITOCHONDRION		RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function	mRNA splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|mRNA splice site selection	mRNA binding|RNA binding	commitment complex|U1 snRNP|U2-type prespliceosome
YOL084W	YOL084W	PHM7	hom	Verified	0.461453322435585	0.322236701429755	no	1510	0.283515115915602	956	NA	FT		PLASMA MEMBRANE		Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YER019W	YER019W	ISC1	hom	Verified	0.46086554277341	0.322447537222657	no	1511	0.33161059887595	1098	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance	response to salt stress|ceramide biosynthetic process|sphingolipid catabolic process	inositol phosphosphingolipid phospholipase activity	mitochondrion|endoplasmic reticulum|integral to mitochondrial outer membrane
YDR051C	YDR051C	DET1	hom	Verified	0.460054271741883	0.322738632892245	no	1512	0.313107459447174	1045	NA	FT		NUCLEUS		Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel	intracellular sterol transport|dephosphorylation	acid phosphatase activity	nucleus|cytoplasm
YPR174C	YPR174C	YPR174C	hom	Verified	0.460033478483037	0.322746095240346	no	1513	0.313260168798327	1044	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication	biological_process	molecular_function	nuclear envelope|spindle pole body
YDL053C	YDL053C	PBP4	hom	Verified	0.458259384485076	0.323383050099584	no	1514	0.329268653020119	1121	NA	FT		NUCLEUS		Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasmic stress granule|cytoplasm
YLL047W_d	YLL047W	YLL047W	hom	Dubious	0.457687858691475	0.323588356018131	no	1515	0.335052666599378	1142	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1	Unknown	Unknown	Unknown
YDL144C	YDL144C	YDL144C	hom	Verified	0.457525698198375	0.323646617782009	no	1516	0.323492509008734	1101	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YLR338W_d	YLR338W	OPI9	hom	Dubious	0.457301166702395	0.323727295621363	no	1517	0.362501046417022	1221	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C	Unknown	Unknown	Unknown
YJR147W	YJR147W	HMS2	hom	Verified	0.456688790652166	0.323947374452195	no	1518	0.309655994154611	1031	NA	FT		NUCLEUS		Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication	pseudohyphal growth	molecular_function	nucleus|cytoplasm
YCR075C	YCR075C	ERS1	hom	Verified	0.456219826055927	0.324115954967207	no	1519	0.31513502529837	1066	NA					Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains	L-cystine transport|transmembrane transport	L-cystine transmembrane transporter activity	endosome|integral to membrane|fungal-type vacuole
YIL087C	YIL087C	AIM19	hom	Verified	0.45606355667106	0.324172137740718	no	1520	0.314520955603796	1085	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth	biological_process	molecular_function	mitochondrion
YOR386W	YOR386W	PHR1	hom	Verified	0.455902004530359	0.324230224007337	no	1521	0.343860045959339	1145	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p	photoreactive repair	mRNA binding|deoxyribodipyrimidine photo-lyase activity	mitochondrion|nucleus
YKR106W	YKR106W	GEX2	hom	Verified	0.45564483940913	0.324322696861428	no	1522	0.309901244359039	1034	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway	glutathione transmembrane transport	solute:hydrogen antiporter activity	integral to membrane|plasma membrane|vacuolar membrane
YMR287C	YMR287C	DSS1	hom	Verified	0.455149993472207	0.324500666778509	no	1523	0.336527020090947	1109	NA	FT		MITOCHONDRION		3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs	mitochondrial RNA catabolic process	exoribonuclease II activity	mitochondrion|mitochondrial degradosome
YNL073W	YNL073W	MSK1	hom	Verified	0.454875589321601	0.324599372722357	no	1524	0.328820480793379	1116	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION	MITOCHONDRION		Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)	tRNA import into mitochondrion|lysyl-tRNA aminoacylation|mitochondrial lysyl-tRNA aminoacylation|mitochondrial translation	lysine-tRNA ligase activity	mitochondrion
YPL185W_d	YPL185W	YPL185W	hom	Dubious	0.454364803433662	0.324783140373313	no	1525	0.333423525404608	1092	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C	Unknown	Unknown	Unknown
YBL102W	YBL102W	SFT2	hom	Verified	0.453279801538489	0.325173637690636	no	1526	0.342469308154931	1160	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5	Golgi to endosome transport	molecular_function	integral to membrane|Golgi membrane
YPL213W	YPL213W	LEA1	hom	Verified	0.45322569830603	0.325193114731354	no	1527	0.327170314973528	1131	NA	FT	RNA PROCESSING	NUCLEUS		Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein	mRNA splicing, via spliceosome	molecular_function	U2 snRNP|U2-type prespliceosome|cytoplasm
YGR193C	YGR193C	PDX1	hom	Verified	0.452959648740776	0.325288898918095	no	1528	0.296255238161892	1048	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core	acetyl-CoA biosynthetic process from pyruvate	structural molecule activity	mitochondrion|mitochondrial pyruvate dehydrogenase complex
YOL027C	YOL027C	MDM38	hom	Verified	0.452886263979876	0.325315321213094	no	1529	0.320780617219264	1077	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome	potassium ion transport|mitochondrial respiratory chain complex III biogenesis|cellular potassium ion homeostasis|proton transport|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis|protein insertion into mitochondrial membrane	ribosome binding	mitochondrion|mitochondrial inner membrane
YNL296W_d	YNL296W	YNL296W	hom	Dubious	0.45283294817441	0.325334518200876	no	1530	0.365922080435204	1214	NA					Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog	Unknown	Unknown	Unknown
YGL014W	YGL014W	PUF4	hom	Verified	0.451896380500086	0.325671816036492	no	1531	0.346462318934417	1180	NA	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|TRANSLATION|GENE SILENCING			Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of translation|protein localization|negative regulation of chromatin silencing involved in replicative cell aging	mRNA binding	cytoplasm
YPL051W	YPL051W	ARL3	hom	Verified	0.451581444562363	0.325785269947812	no	1532	0.35619150034606	1169	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor	intracellular protein transport|Golgi to plasma membrane protein transport|protein localization to organelle	GTPase activity	Golgi apparatus|nuclear outer membrane-endoplasmic reticulum membrane network
YPL118W	YPL118W	MRP51	hom	Verified	0.450839957827261	0.326052450103764	no	1533	0.345292965369472	1172	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences	mitochondrial translational initiation|mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YHR028C	YHR028C	DAP2	hom	Verified	0.450814747640858	0.326061535669315	no	1534	0.344416235212413	1138	NA	FT	PROTEOLYSIS			Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p	protein processing	dipeptidyl-peptidase activity	fungal-type vacuole membrane
YOR150W	YOR150W	MRPL23	hom	Verified	0.450778918213752	0.326074448508685	no	1535	0.362754243242788	1192	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YIL057C	YIL057C	RGI2	hom	Verified	0.450474220033268	0.326184269427217	no	1536	0.341555038361903	1153	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose	energy reserve metabolic process	molecular_function	cytoplasm
YDL241W_p	YDL241W	YDL241W	hom	Uncharacterized	0.450171855387816	0.326293264182989	no	1537	0.314442360858711	1066	NA					Putative protein of unknown function; YDL241W is not an essential gene	biological_process	molecular_function	cellular_component
YBR205W	YBR205W	KTR3	hom	Verified	0.44971310347867	0.326458660895002	no	1538	0.296113344900857	982	NA	FT	CARBOHYDRATE METABOLISM			Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress	N-glycan processing|protein O-linked glycosylation	mannosyltransferase activity	fungal-type vacuole
YEL008W_d	YEL008W	YEL008W	hom	Dubious	0.449572825482148	0.326509243017906	no	1539	0.313455429304394	1031	NA					Hypothetical protein predicted to be involved in metabolism	Unknown	Unknown	Unknown
YMR004W	YMR004W	MVP1	hom	Verified	0.449016964179725	0.326709709550346	no	1540	0.342686535471001	1171	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	NUCLEUS		Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress	protein targeting to vacuole	phosphatidylinositol-3-phosphate binding	nucleus|cytoplasm
YBR170C	YBR170C	NPL4	hom	Verified	0.447966838986331	0.327088564572667	no	1541	0.329175588253664	1109	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)	retrograde protein transport, ER to cytosol|proteasomal ubiquitin-dependent protein catabolic process|mitochondria-associated protein catabolic process|mitotic spindle disassembly|ER-associated protein catabolic process|ER-associated misfolded protein catabolic process|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process	molecular_function	Doa10p ubiquitin ligase complex|integral to membrane|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|Cdc48p-Npl4p-Vms1p AAA ATPase complex|nuclear outer membrane-endoplasmic reticulum membrane network
YDL156W	YDL156W	CMR1	hom	Verified	0.447112096904291	0.327397062590999	no	1542	0.33956262360621	1178	NA	FT		NUCLEUS|CHROMOSOME		DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS	biological_process	DNA binding	nuclear chromatin|nucleus|cytoplasm
YDR073W	YDR073W	SNF11	hom	Verified	0.446473653959532	0.327627569729055	no	1543	0.309354032443519	1049	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex
YMR006C	YMR006C	PLB2	hom	Verified	0.446290084991005	0.327693858699572	no	1544	0.285381200443751	994	NA	FT	LIPID METABOLISM			Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine	glycerophospholipid metabolic process	lysophospholipase activity	extracellular region|fungal-type cell wall
YDL218W_p	YDL218W	YDL218W	hom	Uncharacterized	0.446272839709231	0.327700086458097	no	1545	0.287342229820275	996	NA					Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin	biological_process	molecular_function	integral to membrane|cytoplasm
YHR175W-A_p	YHR175W-A	YHR175W-A	hom	Uncharacterized	0.441939576411257	0.329266465453701	no	1546	0.313929094425107	1036	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YNL068C	YNL068C	FKH2	hom	Verified	0.441576175340366	0.329397963705174	no	1547	0.318707141403821	1077	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication	negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|negative regulation of transcription involved in G1 phase of mitotic cell cycle|Unknown|chromatin remodeling|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle	RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus
YPL264C_p	YPL264C	YPL264C	hom	Uncharacterized	0.441043657277796	0.329590695788169	no	1548	0.317297980574059	1067	NA					Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene	biological_process	molecular_function	integral to membrane
YAR020C	YAR020C	PAU7	hom	Verified	0.440870212479138	0.329653479730284	no	1549	0.333521424338129	1105	NA					Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YGR112W	YGR112W	SHY1	hom	Verified	0.440605847472734	0.329749184410962	no	1550	0.311560437715767	1062	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome	mitochondrial respiratory chain complex IV assembly|aerobic respiration	unfolded protein binding	mitochondrion|integral to membrane|mitochondrial inner membrane
YJL102W	YJL102W	MEF2	hom	Verified	0.440375289245316	0.32983265955728	no	1551	0.342614881964019	1142	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial elongation factor involved in translational elongation	translational elongation	translation elongation factor activity	mitochondrion
YML058W	YML058W	SML1	hom	Verified	0.440149591987277	0.329914382966863	no	1552	0.280571554769751	955	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	NUCLEUS		Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase	mitochondrion organization|response to DNA damage stimulus	enzyme inhibitor activity	nucleus|cytoplasm
YDL190C	YDL190C	UFD2	hom	Verified	0.439204598169419	0.330256646788623	no	1553	0.33668688152029	1123	NA	FT	PROTEOLYSIS	NUCLEUS		Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3	ER-associated protein catabolic process|protein ubiquitination|ubiquitin-dependent protein catabolic process|response to stress	ubiquitin-ubiquitin ligase activity	nucleus|cytoplasm
YAL044C	YAL044C	GCV3	hom	Verified	0.438694282360251	0.33044153528484	no	1554	0.35775423741557	1184	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF	glycine catabolic process|one-carbon metabolic process|protein lipoylation	glycine dehydrogenase (decarboxylating) activity	mitochondrion|glycine cleavage complex
YGL236C	YGL236C	MTO1	hom	Verified	0.438121886690246	0.330648964700125	no	1555	0.345265910809456	1113	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants	mitochondrial tRNA wobble uridine modification	molecular_function	mitochondrion
YDR257C	YDR257C	RKM4	hom	Verified	0.438008045631537	0.330690225556491	no	1556	0.309982339352882	1033	NA	FT		NUCLEUS		Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein	peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	nucleus
YNL138W	YNL138W	SRV2	hom	Verified	0.437789034701596	0.33076961024712	no	1557	0.40319634275147	1328	NA	FT	SIGNALING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis	cytoskeleton organization|Ras protein signal transduction	cytoskeletal protein binding|adenylate cyclase binding	mating projection tip|actin cortical patch
YNR044W	YNR044W	AGA1	hom	Verified	0.437294932390924	0.330948735010873	no	1558	0.292892208121659	1013	NA					Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YDL176W	YDL176W	YDL176W	hom	Verified	0.437065290482575	0.331031999271711	no	1559	0.309308502499982	1038	NA					Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene	biological_process	molecular_function	cellular_component
YJR019C	YJR019C	TES1	hom	Verified	0.436450914683833	0.331254802595225	no	1560	0.329766883646417	1110	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids	fatty acid beta-oxidation|fatty acid oxidation	acyl-CoA hydrolase activity	mitochondrion|peroxisome
YDR287W	YDR287W	INM2	hom	Verified	0.435449875082763	0.331617957471478	no	1561	0.339127051132121	1162	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM			Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy	inositol phosphate dephosphorylation	inositol monophosphate 1-phosphatase activity	cellular_component
YMR098C	YMR098C	ATP25	hom	Verified	0.433158218904763	0.332449914959689	no	1562	0.347271124901706	1165	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene	mRNA stabilization|mitochondrial proton-transporting ATP synthase complex assembly	molecular_function	mitochondrion|mitochondrial inner membrane
YNL305C	YNL305C	BXI1	hom	Verified	0.432331526952979	0.332750238246754	no	1563	0.310927466441899	1035	NA	FT	SIGNALING	ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p	endoplasmic reticulum unfolded protein response|apoptotic process|calcium-mediated signaling	molecular_function	mitochondrion|integral to membrane|endoplasmic reticulum|fungal-type vacuole
YKL010C	YKL010C	UFD4	hom	Verified	0.431553516088168	0.333032974575972	no	1564	0.335432265891815	1116	NA	FT	PROTEOLYSIS	MITOCHONDRION		Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress	protein monoubiquitination|protein polyubiquitination	ubiquitin-protein ligase activity	mitochondrion|cytoplasm
YOR338W_p	YOR338W	YOR338W	hom	Uncharacterized	0.430891044226657	0.333273797813038	no	1565	0.316535342890812	1103	NA	FT	TRANSCRIPTION FROM RNA POL II			Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YOR111W_p	YOR111W	YOR111W	hom	Uncharacterized	0.430317523495788	0.33348234086724	no	1566	0.317564142967571	1101	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL129W	YNL129W	NRK1	hom	Verified	0.42998250582468	0.333604183488881	no	1567	0.317624552964354	1075	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis	nicotinamide riboside metabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|NAD biosynthetic process	nicotinic acid riboside kinase activity|ribosylnicotinamide kinase activity	cytoplasm
YJR107W_p	YJR107W	YJR107W	hom	Uncharacterized	0.429497582079465	0.333780576559101	no	1568	0.322825924682767	1070	NA	FT	LIPID METABOLISM			Putative lipase	biological_process	lipase activity	cellular_component
YDL236W	YDL236W	PHO13	hom	Verified	0.428828046601789	0.334024183309386	no	1569	0.340827828374441	1134	NA	FT		NUCLEUS		Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity	protein dephosphorylation	4-nitrophenylphosphatase activity|phosphoprotein phosphatase activity|alkaline phosphatase activity	nucleus|cytoplasm
YFL048C	YFL048C	EMP47	hom	Verified	0.428652107232445	0.334088209477865	no	1570	0.332506051257135	1123	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport	ER to Golgi vesicle-mediated transport	glycoprotein binding	fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YER045C	YER045C	ACA1	hom	Verified	0.428631210847876	0.334095814210646	no	1571	0.326715891388318	1109	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YMR193W	YMR193W	MRPL24	hom	Verified	0.427881992001813	0.334368519235103	no	1572	0.310944225167156	1050	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOL052C-A	YOL052C-A	DDR2	hom	Verified	0.427722800608112	0.334426473909729	no	1573	0.334254059640494	1120	NA					Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication	response to stress	molecular_function	fungal-type vacuole|cytoplasm
YHR110W	YHR110W	ERP5	hom	Verified	0.426737437828169	0.334785289479845	no	1574	0.310171791146982	1053	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YPL092W	YPL092W	SSU1	hom	Verified	0.426640953898192	0.334820431799672	no	1575	0.34079130482995	1109	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein	sulfite transport	sulfite transmembrane transporter activity	integral to membrane|plasma membrane
YMR037C	YMR037C	MSN2	hom	Verified	0.425493315477763	0.33523854674466	no	1576	0.327027787497022	1090	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|cellular response to methylmercury|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YGL021W	YGL021W	ALK1	hom	Verified	0.424553177830845	0.335581215877374	no	1577	0.341772645350739	1140	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION			Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins	mitosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YLR142W	YLR142W	PUT1	hom	Verified	0.424159352601116	0.33572480121893	no	1578	0.328953320570989	1088	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source	glutamate biosynthetic process|proline catabolic process to glutamate	proline dehydrogenase activity	mitochondrion
YEL036C	YEL036C	ANP1	hom	Verified	0.423238551426179	0.336060611100192	no	1579	0.371550877809556	1226	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity|mannosyltransferase activity	alpha-1,6-mannosyltransferase complex|Golgi cis cisterna
YMR304W	YMR304W	UBP15	hom	Verified	0.423149298783489	0.336093167890145	no	1580	0.361214509530004	1194	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p	protein deubiquitination	ubiquitin-specific protease activity	peroxisome|cytoplasm
YCR105W	YCR105W	ADH7	hom	Verified	0.422468682195263	0.336341477616724	no	1581	0.353134747127263	1192	NA	FT	OXIDATION-REDUCTION PROCESS			NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance	alcohol metabolic process	alcohol dehydrogenase (NADP+) activity	cellular_component
YLR425W	YLR425W	TUS1	hom	Verified	0.422457588858522	0.336345525396595	no	1582	0.402394945895345	1316	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH		Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate	fungal-type cell wall organization|signal transduction	Rho guanyl-nucleotide exchange factor activity	incipient cellular bud site|cellular bud neck
YNL108C_p	YNL108C	YNL108C	hom	Uncharacterized	0.422094945720899	0.3364778584793	no	1583	0.351039452716257	1184	NA	FT		NUCLEUS		Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YIL077C_p	YIL077C	YIL077C	hom	Uncharacterized	0.421376302360931	0.33674016039575	no	1584	0.352359781131847	1175	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	biological_process	molecular_function	mitochondrion
YOL019W-A_p	YOL019W-A	YOL019W-A	hom	Uncharacterized	0.42127998138331	0.33677532320245	no	1585	0.331430139565562	1105	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YGL176C_p	YGL176C	YGL176C	hom	Uncharacterized	0.421152504113254	0.336821862077193	no	1586	0.346713180080432	1131	NA					Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype	biological_process	molecular_function	cellular_component
YGL260W_p	YGL260W	YGL260W	hom	Uncharacterized	0.420667902120208	0.336998801367361	no	1587	0.328107250388588	1115	NA					Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium	biological_process	molecular_function	cellular_component
YGL027C	YGL027C	CWH41	hom	Verified	0.420399057364083	0.337096978307151	no	1588	0.353651762442154	1181	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress	fungal-type cell wall biogenesis|protein N-linked glycosylation	mannosyl-oligosaccharide glucosidase activity	endoplasmic reticulum membrane
YNR024W	YNR024W	MPP6	hom	Verified	0.420268825134284	0.337144540605455	no	1589	0.33577319949721	1102	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes	nuclear mRNA surveillance of spliceosomal pre-mRNA splicing|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	poly(U) RNA binding	ribosome|nucleus|nuclear exosome (RNase complex)|TRAMP complex
YKL123W_d	YKL123W	YKL123W	hom	Dubious	0.420037537326333	0.337229015972194	no	1590	0.344846589478616	1155	NA					Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4	Unknown	Unknown	Unknown
YKR078W	YKR078W	YKR078W	hom	Verified	0.419615574939258	0.3373831543062	no	1591	0.344947372544358	1154	NA					Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)	biological_process	phosphatidylinositol-3-phosphate binding	cytoplasm
YPL193W	YPL193W	RSA1	hom	Verified	0.419488038092367	0.337429747520989	no	1592	0.365092125260452	1230	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly	ribosomal large subunit assembly	molecular_function	nucleoplasm
YHR151C	YHR151C	MTC6	hom	Verified	0.419384437527846	0.337467597895199	no	1593	0.3428084364719	1152	NA					Protein of unknown function; mtc6 is synthetically sick with cdc13-1	biological_process	molecular_function	cellular_component
YDR095C_d	YDR095C	YDR095C	hom	Dubious	0.419166227888726	0.337547325972484	no	1594	0.341598214294121	1149	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR172W	YMR172W	HOT1	hom	Verified	0.419088023953432	0.337575901414051	no	1595	0.316517311813251	1064	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p	cellular hyperosmotic salinity response|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YMR041C	YMR041C	ARA2	hom	Verified	0.41877665939849	0.337689682208097	no	1596	0.327870160453938	1102	NA	FT	OXIDATION-REDUCTION PROCESS			NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase	dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinose 1-dehydrogenase [NAD(P)+] activity	cellular_component
YER046W	YER046W	SPO73	hom	Verified	0.41863910431051	0.337739953179323	no	1597	0.328195449348039	1105	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis	ascospore wall assembly|ascospore formation	molecular_function	cytosol
YGR027C	YGR027C	RPS25A	hom	Verified	0.417994467850825	0.33797558099672	no	1598	0.355290147109129	1183	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR009W	YDR009W	GAL3	hom	Verified	0.417991146815015	0.337976795067749	no	1599	0.321844836543921	1081	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication	maintenance of protein location|galactose metabolic process|positive regulation of transcription from RNA polymerase II promoter by galactose	protein binding	nucleus|cytoplasm
YBL062W_d	YBL062W	YBL062W	hom	Dubious	0.417830047335088	0.338035690226579	no	1600	0.365886166914021	1232	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR098C	YLR098C	CHA4	hom	Verified	0.417276110079827	0.338238230265922	no	1601	0.34845565987116	1125	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain	positive regulation of transcription, DNA-dependent|cellular amino acid catabolic process	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YBL063W	YBL063W	KIP1	hom	Verified	0.417225466305819	0.338256749847905	no	1602	0.321579447688778	1090	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions	mitotic anaphase B|microtubule depolymerization|spindle pole body separation|plasmid partitioning|mitotic sister chromatid segregation	microtubule motor activity|structural constituent of cytoskeleton	spindle microtubule|kinesin complex|spindle pole body
YPL256C	YPL256C	CLN2	hom	Verified	0.416967109330122	0.338351232766558	no	1603	0.328394732360232	1088	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)	regulation of cyclin-dependent protein kinase activity|re-entry into mitotic cell cycle after pheromone arrest	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YGR153W_p	YGR153W	YGR153W	hom	Uncharacterized	0.416791901736292	0.338415313178161	no	1604	0.331971359440266	1120	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YML097C	YML097C	VPS9	hom	Verified	0.416669420207533	0.338460112342109	no	1605	0.327029668705086	1095	NA	FF|FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT			A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin	vacuole inheritance|protein targeting to vacuole	ubiquitin binding|guanyl-nucleotide exchange factor activity	cytosol
YNL154C	YNL154C	YCK2	hom	Verified	0.416470253697109	0.338532964886725	no	1606	0.345284154128296	1183	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication	endocytosis|cell morphogenesis|protein phosphorylation|cytokinesis|response to glucose stimulus	protein serine/threonine kinase activity|protein kinase activity	plasma membrane|cellular bud neck|mating projection
YBR286W	YBR286W	APE3	hom	Verified	0.415057100802973	0.339050051433546	no	1607	0.343651125936753	1161	NA	FT	PROTEOLYSIS			Vacuolar aminopeptidase Y, processed to mature form by Prb1p	vacuolar protein catabolic process	aminopeptidase activity	fungal-type vacuole
YLR320W	YLR320W	MMS22	hom	Verified	0.414876875250077	0.339116019567278	no	1608	0.341044277305747	1160	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation	replication fork processing|double-strand break repair|recombinational repair|meiotic sister chromatid segregation|response to DNA damage stimulus	molecular_function	Cul8-RING ubiquitin ligase complex|nucleus
YJL023C	YJL023C	PET130	hom	Verified	0.414395779073699	0.339292139820368	no	1609	0.333928825817644	1120	NA	FT		MITOCHONDRION		Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YBR219C_p	YBR219C	YBR219C	hom	Uncharacterized	0.413890003066537	0.339477332758147	no	1610	0.339548114922502	1106	NA					Putative protein of unknown function; YBR219C is not an essential gene	biological_process	molecular_function	integral to membrane
YDL175C	YDL175C	AIR2	hom	Verified	0.413526064403223	0.339610615085405	no	1611	0.346108090596543	1163	NA	FT	RNA PROCESSING	NUCLEUS		RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication	nuclear polyadenylation-dependent CUT catabolic process|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|tRNA modification	polynucleotide adenylyltransferase activity|RNA binding|protein binding, bridging	nucleolus|TRAMP complex
YCL010C	YCL010C	SGF29	hom	Verified	0.412964243766191	0.33981640551625	no	1612	0.326866335375746	1102	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation	histone H3-K14 acetylation|cellular protein complex localization|histone H3-K18 acetylation|cellular protein localization|histone H3-K9 acetylation|positive regulation of transcription from RNA polymerase II promoter	methylated histone residue binding|RNA polymerase II transcription factor recruiting transcription factor activity	Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YLR441C	YLR441C	RPS1A	hom	Verified	0.412905710493746	0.339837848535968	no	1613	0.358320873924818	1198	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YLR292C	YLR292C	SEC72	hom	Verified	0.41246919379549	0.33999777796079	no	1614	0.354252703264328	1174	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	posttranslational protein targeting to membrane, translocation	protein transporter activity	Sec62/Sec63 complex|endoplasmic reticulum membrane
YOR022C_p	YOR022C	YOR022C	hom	Uncharacterized	0.412047030194483	0.340152476142552	no	1615	0.332174284348462	1102	NA	FT	LIPID METABOLISM	MITOCHONDRION		Putative carboxylic ester hydrolase; similar to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	phospholipase activity	mitochondrion
YNL004W	YNL004W	HRB1	hom	Verified	0.412004940172173	0.340167901141064	no	1616	0.355358419383897	1186	NA	FT	RNA LOCALIZATION	NUCLEUS		Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication	poly(A)+ mRNA export from nucleus	RNA binding	integral to membrane|nucleus|cytoplasm
YMR304C-A_d	YMR304C-A	YMR304C-A	hom	Dubious	0.41155644281578	0.340332281429933	no	1617	0.340607406374753	1147	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10	Unknown	Unknown	Unknown
YGL028C	YGL028C	SCW11	hom	Verified	0.410559163333921	0.340697906433276	no	1618	0.351045994740195	1182	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM			Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p	cytokinesis, completion of separation	glucan endo-1,3-beta-D-glucosidase activity	fungal-type cell wall
YGR180C	YGR180C	RNR4	hom	Verified	0.410406523315076	0.340753880904445	no	1619	0.374580575705126	1223	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress	cofactor biosynthetic process|deoxyribonucleotide biosynthetic process	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ribonucleoside-diphosphate reductase complex|nucleus|cytoplasm
YPL148C	YPL148C	PPT2	hom	Verified	0.409698844192412	0.341013439018059	no	1620	0.3751623235714	1258	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation	protein-cofactor linkage	holo-[acyl-carrier-protein] synthase activity	mitochondrion
YOR038C	YOR038C	HIR2	hom	Verified	0.408206479091887	0.341561045924786	no	1621	0.336037687110237	1137	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p	DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter	nucleosome binding|transcription corepressor activity|DNA binding	HIR complex|nucleus
YDR179C	YDR179C	CSN9	hom	Verified	0.407916065888659	0.341667648664299	no	1622	0.340626920713232	1142	NA	FT	SIGNALING	NUCLEUS		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	molecular_function	signalosome
YOL080C	YOL080C	REX4	hom	Verified	0.4076965313125	0.341748242181861	no	1623	0.323820654303773	1095	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly	ribosomal large subunit assembly|rRNA processing	3'-5' exonuclease activity	nucleolus|nucleus
YKL053C-A	YKL053C-A	MDM35	hom	Verified	0.407535729493378	0.341807278846215	no	1624	0.354359252583131	1215	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION		Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	mitochondrion organization|mitochondrial respiratory chain complex assembly	molecular_function	nucleus|cytoplasm|mitochondrial intermembrane space
YBR203W	YBR203W	COS111	hom	Verified	0.407339776290968	0.341879226194072	no	1625	0.382712209861826	1256	NA	FT	SIGNALING	MITOCHONDRION		Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	signal transduction	molecular_function	mitochondrion
YLR053C_p	YLR053C	YLR053C	hom	Uncharacterized	0.405428230376433	0.342581381725069	no	1626	0.323203328585703	1053	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR156C	YBR156C	SLI15	hom	Verified	0.405309892258251	0.342624867999749	no	1627	0.343451758339538	1147	NA	FT	CELL DIVISION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON		Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly	chromosome segregation|protein phosphorylation|regulation of cytokinesis	protein kinase activator activity	spindle microtubule|spindle midzone|chromosome passenger complex|kinetochore microtubule
YGR202C	YGR202C	PCT1	hom	Verified	0.404839489116587	0.342797749913479	no	1628	0.314610902273911	1084	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity	phosphatidylcholine biosynthetic process|CDP-choline pathway	choline-phosphate cytidylyltransferase activity	nuclear envelope|Golgi apparatus|nucleus
YGL034C_d	YGL034C	YGL034C	hom	Dubious	0.404787851887085	0.342816729562996	no	1629	0.357523769639783	1174	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML107C	YML107C	PML39	hom	Verified	0.404230957844228	0.343021445331148	no	1630	0.327065118916919	1087	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes	maintenance of RNA location	molecular_function	ribosome|nuclear pore
YER050C	YER050C	RSM18	hom	Verified	0.403458009848822	0.343305659489418	no	1631	0.355921323691617	1178	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YPR184W	YPR184W	GDB1	hom	Verified	0.402669097332835	0.343595835237139	no	1632	0.349792795198341	1189	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress	glycogen catabolic process	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity	mitochondrion|cytoplasm
YOR304W	YOR304W	ISW2	hom	Verified	0.402536619633889	0.34364457188436	no	1633	0.327954763962376	1113	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth	negative regulation of transcription from RNA polymerase II promoter by pheromones|nucleosome positioning|termination of RNA polymerase II transcription|negative regulation of antisense RNA transcription|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere	single-stranded DNA binding|DNA translocase activity	chromatin accessibility complex|nucleus
YBL089W	YBL089W	AVT5	hom	Verified	0.402246724762794	0.343751229119081	no	1634	0.371405141522672	1211	NA					Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication	transport	transporter activity	integral to membrane
YDR015C_d	YDR015C	YDR015C	hom	Dubious	0.402204668410036	0.343766703397096	no	1635	0.334442020424716	1126	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A	Unknown	Unknown	Unknown
YLR184W_d	YLR184W	YLR184W	hom	Dubious	0.401920898957997	0.343871120798624	no	1636	0.318565797530413	1100	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR443C	YDR443C	SSN2	hom	Verified	0.40188304209129	0.343885051724503	no	1637	0.338651234815549	1120	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II transcription coactivator activity|RNA polymerase II transcription factor recruiting transcription factor activity	mediator complex
YOL141W	YOL141W	PPM2	hom	Verified	0.401662536594799	0.343966199623231	no	1638	0.307408537396827	1038	NA	FT	RNA PROCESSING	MITOCHONDRION		AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p	tRNA methylation|wybutosine biosynthetic process	tRNA methyltransferase activity	mitochondrion|cytoplasm
YFL047W	YFL047W	RGD2	hom	Verified	0.400879220812596	0.344254524589412	no	1639	0.349846509107239	1161	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress	small GTPase mediated signal transduction	Rho GTPase activator activity	cellular bud neck|cytoplasm
YFL010C	YFL010C	WWM1	hom	Verified	0.400538497835501	0.344379967082482	no	1640	0.338595815866564	1144	NA	FT		NUCLEUS|MITOCHONDRION		WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1	biological_process	molecular_function	mitochondrion|nucleus|cytoplasm
YER067C-A_d	YER067C-A	YER067C-A	hom	Dubious	0.400522930170789	0.344385698970815	no	1641	0.327876644723234	1078	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W	Unknown	Unknown	Unknown
YNL065W	YNL065W	AQR1	hom	Verified	0.399821079549806	0.344644151806528	no	1642	0.334803607393707	1139	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress	monocarboxylic acid transport|drug transmembrane transport|amino acid export	monocarboxylic acid transmembrane transporter activity|drug transmembrane transporter activity	integral to membrane|plasma membrane
YMR101C	YMR101C	SRT1	hom	Verified	0.399670583480164	0.344699580648396	no	1643	0.327598236227259	1070	NA	FT	CARBOHYDRATE METABOLISM			Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase	protein glycosylation	dehydrodolichyl diphosphate synthase activity|prenyltransferase activity	lipid particle
YML090W_d	YML090W	YML090W	hom	Dubious	0.399602362868478	0.344724707914477	no	1644	0.339676001375106	1134	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source	Unknown	Unknown	Unknown
YDL173W	YDL173W	PAR32	hom	Verified	0.399022457048752	0.344938328604376	no	1645	0.363690836931013	1212	NA					Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene	biological_process	molecular_function	cytoplasm
YDR066C	YDR066C	RTR2	hom	Verified	0.396873376164259	0.345730419036127	no	1646	0.349776676817663	1156	NA	FT		NUCLEUS		Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YMR118C_p	YMR118C	SHH3	hom	Uncharacterized	0.39612563151914	0.346006175212145	no	1647	0.333505831897008	1126	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase	biological_process	molecular_function	integral to membrane
YDR524W-C_p	YDR524W-C	YDR524W-C	hom	Uncharacterized	0.396072392703218	0.346025811946343	no	1648	0.353844713165465	1180	NA					Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin	biological_process	molecular_function	cellular_component
YLR068W	YLR068W	FYV7	hom	Verified	0.395836338746235	0.346112883648779	no	1649	0.354042425267078	1190	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|nucleus
YML030W	YML030W	RCF1	hom	Verified	0.395566458553455	0.346212442585321	no	1650	0.346594563168013	1176	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast	mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain supercomplex assembly	molecular_function	mitochondrion|mitochondrial respiratory chain supercomplex|integral to mitochondrial inner membrane|mitochondrial respiratory chain complex IV
YOR327C	YOR327C	SNC2	hom	Verified	0.395435411308427	0.346260789812856	no	1651	0.33857942230187	1121	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication	endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion	SNAP receptor activity	SNARE complex|trans-Golgi network|endosome|transport vesicle membrane
YDR124W_p	YDR124W	YDR124W	hom	Uncharacterized	0.394916213953267	0.346452361784141	no	1652	0.335114665793399	1095	NA					Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor	biological_process	molecular_function	cellular_component
YPR023C	YPR023C	EAF3	hom	Verified	0.394670263786179	0.346543125495995	no	1653	0.326186485495652	1113	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition	DNA repair|histone acetylation|regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|histone deacetylation	histone acetyltransferase activity	Rpd3S complex|histone acetyltransferase complex|Rpd3L complex|NuA4 histone acetyltransferase complex
YCL014W	YCL014W	BUD3	hom	Verified	0.394027960526027	0.346780198090734	no	1654	0.346613248633596	1171	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding	cellular bud site selection|axial cellular bud site selection|cytokinesis	molecular_function	cellular bud neck contractile ring|cellular bud neck
YIL030C	YIL030C	SSM4	hom	Verified	0.393925131950686	0.346818157446096	no	1655	0.359160492243696	1222	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation	ER-associated protein catabolic process	ubiquitin-protein ligase activity	nuclear envelope|integral to endoplasmic reticulum membrane|Doa10p ubiquitin ligase complex|integral to membrane|nuclear inner membrane
YBL001C	YBL001C	ECM15	hom	Verified	0.393675616246344	0.346910273013277	no	1656	0.337252411836334	1126	NA	FT	CELL WALL ORG/BIOGENESIS	NUCLEUS		Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis	fungal-type cell wall organization	molecular_function	nucleus|cytoplasm
YJL154C	YJL154C	VPS35	hom	Verified	0.393370473050661	0.347022937294121	no	1657	0.373893724408526	1221	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YLR241W_p	YLR241W	YLR241W	hom	Uncharacterized	0.392915832711485	0.347190823656011	no	1658	0.334516966364866	1121	NA					Putative protein of unknown function, may be involved in detoxification	biological_process	molecular_function	integral to membrane
YCR071C	YCR071C	IMG2	hom	Verified	0.392680801415303	0.347277626109427	no	1659	0.35238478197181	1189	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGR129W	YGR129W	SYF2	hom	Verified	0.39257923423902	0.347315139678739	no	1660	0.368994561897466	1243	NA	FT	RNA PROCESSING	NUCLEUS		Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest	mRNA splicing, via spliceosome	first spliceosomal transesterification activity|second spliceosomal transesterification activity	U2-type post-mRNA release spliceosomal complex|Prp19 complex|U2-type prespliceosome|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YKL055C	YKL055C	OAR1	hom	Verified	0.392267482152229	0.347430293832206	no	1661	0.36349431776668	1220	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p	fatty acid metabolic process|aerobic respiration	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	mitochondrion
YOR076C	YOR076C	SKI7	hom	Verified	0.39207377522483	0.347501851874291	no	1662	0.357604940754785	1176	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM			Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay|nonfunctional rRNA decay	protein binding, bridging	Ski complex|cytoplasmic exosome (RNase complex)|cytoplasm
YAL054C	YAL054C	ACS1	hom	Verified	0.391545877808169	0.347696892127718	no	1663	0.337735438068674	1127	NA	FT	KETONE METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions	acetate fermentation|histone acetylation|acetyl-CoA biosynthetic process	acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity	cytosol|mitochondrion|integral to membrane
YKL162C_p	YKL162C	YKL162C	hom	Uncharacterized	0.391310119676244	0.347784009815747	no	1664	0.329579075121151	1094	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion
YEL056W	YEL056W	HAT2	hom	Verified	0.391158151095276	0.347840169727421	no	1665	0.330784495989721	1072	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing	histone acetylation|chromatin assembly or disassembly|chromatin silencing at telomere	histone acetyltransferase activity|histone binding	histone acetyltransferase complex|nucleus|cytoplasm
YLR144C	YLR144C	ACF2	hom	Verified	0.391073719615287	0.347871372780553	no	1666	0.343835255751233	1167	NA	FT	CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION			Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress	actin cytoskeleton organization	glucan endo-1,3-beta-D-glucosidase activity	intracellular
YCR067C	YCR067C	SED4	hom	Verified	0.391043284807866	0.347882620720826	no	1667	0.34631803984141	1131	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p	positive regulation of GTPase activity|regulation of COPII vesicle coating	Sar GTPase activator activity	integral to endoplasmic reticulum membrane
YDR530C	YDR530C	APA2	hom	Verified	0.390886397291544	0.347940604529135	no	1668	0.312023031537897	1035	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication	nucleoside catabolic process	bis(5'-nucleosyl)-tetraphosphatase activity	nucleus|cytoplasm
YDR128W	YDR128W	MTC5	hom	Verified	0.390386807989461	0.34812527063207	no	1669	0.3329272560997	1109	NA					Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress	biological_process	molecular_function	fungal-type vacuole membrane|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YOR337W	YOR337W	TEA1	hom	Verified	0.390120582271042	0.348223691908587	no	1670	0.338228888182552	1150	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein	transcription, DNA-dependent	sequence-specific DNA binding|DNA binding	nucleus
YEL051W	YEL051W	VMA8	hom	Verified	0.389849270319907	0.348324004037387	no	1671	0.372500604608849	1240	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YHR022C-A_p	YHR022C-A	YHR022C-A	hom	Uncharacterized	0.389429240532411	0.348479322517182	no	1672	0.3438053226171	1164	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YLR404W	YLR404W	FLD1	hom	Verified	0.38868637195737	0.348754082411265	no	1673	0.349996821533093	1153	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy	lipid particle organization	molecular_function	integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum
YIL042C	YIL042C	PKP1	hom	Verified	0.388532735435078	0.348810916843372	no	1674	0.337476000309657	1112	NA	FT	SIGNALING|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p	peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization	protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity	mitochondrion
YGR215W	YGR215W	RSM27	hom	Verified	0.388525117316883	0.348813735085937	no	1675	0.351753232595784	1172	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YFL050C	YFL050C	ALR2	hom	Verified	0.387844205526898	0.349065664904849	no	1676	0.360284794970703	1200	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition	magnesium ion transport|cation transport|transmembrane transport	inorganic cation transmembrane transporter activity	integral to membrane|plasma membrane
YAL020C	YAL020C	ATS1	hom	Verified	0.387803103279299	0.349080874411644	no	1677	0.354684318961508	1195	NA	FT	RNA PROCESSING|CELL DIVISION|CYTOSKELETON ORGANIZATION			Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle	microtubule-based process|budding cell bud growth|microtubule cytoskeleton organization|tRNA wobble uridine modification	molecular_function	cytoplasm
YEL054C	YEL054C	RPL12A	hom	Verified	0.38721947364074	0.349296867315903	no	1678	0.338775388877156	1150	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome	cytosolic large ribosomal subunit
YOL159C-A	YOL159C-A	YOL159C-A	hom	Verified	0.386700046815039	0.349489140746109	no	1679	0.328608100920506	1078	NA	FT		NUCLEUS		Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	nucleus|cytoplasm
YLR382C	YLR382C	NAM2	hom	Verified	0.386383508204774	0.349606331082046	no	1680	0.368900488470067	1189	NA	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance	Group I intron splicing|leucyl-tRNA aminoacylation|mitochondrial translation	mRNA binding|leucine-tRNA ligase activity	mitochondrion
YHR113W	YHR113W	APE4	hom	Verified	0.386329429082588	0.349626353929738	no	1681	0.342099491480646	1176	NA	FT	PROTEOLYSIS			Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family	proteolysis	aminopeptidase activity	fungal-type vacuole lumen|ribosome|cytoplasm
YDR425W	YDR425W	SNX41	hom	Verified	0.385772644393806	0.3498325283198	no	1682	0.331651100744606	1103	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT			Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p	retrograde transport, endosome to Golgi	phosphatidylinositol binding|phosphatidylinositol-3-phosphate binding	endosome
YCL063W	YCL063W	VAC17	hom	Verified	0.385556975704568	0.349912401184259	no	1683	0.345255817163792	1174	NA					Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p	vacuole inheritance	protein anchor	fungal-type vacuole membrane
YGL194C	YGL194C	HOS2	hom	Verified	0.385375835014464	0.34997949174191	no	1684	0.337376052777456	1137	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING	NUCLEUS|CHROMOSOME		Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS	negative regulation of meiosis|chromatin organization|regulation of transcription, DNA-dependent|positive regulation of stress-activated MAPK cascade|histone deacetylation	NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity	Rpd3L-Expanded complex|Set3 complex
YBR277C_d	YBR277C	YBR277C	hom	Dubious	0.384368796888549	0.350352562027048	no	1685	0.358676444768007	1228	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W	Unknown	Unknown	Unknown
YGL037C	YGL037C	PNC1	hom	Verified	0.384210482467954	0.350411224795756	no	1686	0.332943451850235	1107	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING	NUCLEUS		Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress	replicative cell aging|chromatin silencing at rDNA|nicotinate nucleotide salvage|chromatin silencing at telomere	nicotinamidase activity	nucleus|peroxisome|cytoplasm
YGL085W_p	YGL085W	LCL3	hom	Uncharacterized	0.383962555938364	0.350503100138503	no	1687	0.339720019156919	1159	NA	FT		MITOCHONDRION		Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	mitochondrion
YIR026C	YIR026C	YVH1	hom	Verified	0.383800987683961	0.350562977981678	no	1688	0.35480783878625	1188	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|CELL WALL ORG/BIOGENESIS	NUCLEUS		Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases	meiosis|ascospore wall assembly|ribosomal large subunit assembly|cAMP-mediated signaling|protein dephosphorylation	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	nucleus|preribosome, large subunit precursor|cytoplasm
YLR043C	YLR043C	TRX1	hom	Verified	0.38366356882598	0.350613908883843	no	1689	0.348549184418708	1171	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress	vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic	disulfide oxidoreductase activity	cytosol|fungal-type vacuole
YMR286W	YMR286W	MRPL33	hom	Verified	0.383525481928153	0.350665090083354	no	1690	0.343069957754012	1163	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGL017W	YGL017W	ATE1	hom	Verified	0.38326314863959	0.350762330035074	no	1691	0.336886826382995	1127	NA	FT	PROTEOLYSIS			Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway	cellular protein modification process|protein arginylation	arginyltransferase activity	cytoplasm
YLR199C	YLR199C	PBA1	hom	Verified	0.382659337253137	0.350986183949668	no	1692	0.325145782849063	1098	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly	proteasome assembly	molecular_function	cytoplasm
YHR104W	YHR104W	GRE3	hom	Verified	0.382426382752865	0.35107256213002	no	1693	0.350726963292164	1148	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress	galactose catabolic process|cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process|response to stress	D-xylose:NADP reductase activity|mRNA binding|glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity	nucleus|cytoplasm
YGR101W	YGR101W	PCP1	hom	Verified	0.382208265506011	0.351153445718749	no	1694	0.359847466243936	1199	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases	signal peptide processing|regulation of mitochondrion organization	serine-type endopeptidase activity	integral to membrane|mitochondrial inner membrane
YCL048W	YCL048W	SPS22	hom	Verified	0.382007387670765	0.351227942446992	no	1695	0.349740502185557	1133	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall	ascospore wall assembly|fungal-type cell wall organization	molecular_function	plasma membrane
YHL020C	YHL020C	OPI1	hom	Verified	0.381534536869905	0.35140332451365	no	1696	0.364472158467207	1239	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|SIGNALING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance	endoplasmic reticulum unfolded protein response|negative regulation of transcription from RNA polymerase II promoter|phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	transcription corepressor activity	nuclear membrane|nucleoplasm|nuclear envelope|endoplasmic reticulum|nucleus
YPR058W	YPR058W	YMC1	hom	Verified	0.381525763539715	0.351406578872553	no	1697	0.346848982344689	1115	NA	FT		MITOCHONDRION		Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication	mitochondrial transport	organic acid transmembrane transporter activity	mitochondrion|integral to membrane
YBL043W	YBL043W	ECM13	hom	Verified	0.381290244111953	0.35149394597748	no	1698	0.320600165519168	1076	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cellular_component
YBR169C	YBR169C	SSE2	hom	Verified	0.381129401854912	0.35155361572296	no	1699	0.305540094988674	1006	NA					Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication	protein folding|protein refolding	adenyl-nucleotide exchange factor activity	cytoplasm
YAL013W	YAL013W	DEP1	hom	Verified	0.380959587269763	0.351616618019491	no	1700	0.360832778319443	1196	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|regulation of DNA-dependent DNA replication initiation|Unknown	molecular_function	Rpd3L-Expanded complex|Rpd3L complex
YNL255C	YNL255C	GIS2	hom	Verified	0.380556459578756	0.351766197289682	no	1701	0.348472762717364	1177	NA	FT	TRANSLATION		RIBOSOME	Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2	positive regulation of translation	mRNA binding|translation regulator activity|single-stranded DNA binding	polysomal ribosome|cytoplasm
YKL166C	YKL166C	TPK3	hom	Verified	0.380238009043348	0.351884373591585	no	1702	0.333683897245663	1094	NA	FT	SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication	protein phosphorylation|mitochondrion organization|Ras protein signal transduction	cAMP-dependent protein kinase activity|protein kinase activity	cAMP-dependent protein kinase complex|nucleus|cytoplasm
YIL114C	YIL114C	POR2	hom	Verified	0.380063514527159	0.351949134197181	no	1703	0.348845753046223	1147	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication	DNA transport|ion transport|cell redox homeostasis	voltage-gated anion channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane
YOL160W_d	YOL160W	YOL160W	hom	Dubious	0.379159074701614	0.352284870099159	no	1704	0.334069757380366	1115	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL010W	YDL010W	GRX6	hom	Verified	0.378911647564064	0.352376737267104	no	1705	0.349264567144963	1127	NA	FT	RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication	cellular response to oxidative stress	glutathione-disulfide reductase activity|iron ion binding|protein homodimerization activity|2 iron, 2 sulfur cluster binding	integral to membrane|Golgi apparatus|Golgi lumen|endoplasmic reticulum membrane|fungal-type vacuole|cis-Golgi network
YPR198W	YPR198W	SGE1	hom	Verified	0.378090002627276	0.352681867401804	no	1706	0.378226755898326	1249	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations	response to drug|drug transport	drug transmembrane transporter activity	integral to membrane|integral to plasma membrane
YNR039C	YNR039C	ZRG17	hom	Verified	0.378034478253989	0.352702490629952	no	1707	0.330516329963874	1105	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency	zinc ion transport	zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YMR294W-A_d	YMR294W-A	YMR294W-A	hom	Dubious	0.377846560475841	0.352772291499286	no	1708	0.375323101636541	1234	NA					Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents	Unknown	Unknown	Unknown
YDL216C	YDL216C	RRI1	hom	Verified	0.377178920354749	0.353020322267479	no	1709	0.352029971225756	1185	NA	FT	SIGNALING|PROTEOLYSIS	NUCLEUS		Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	metalloendopeptidase activity	signalosome
YKL151C	YKL151C	YKL151C	hom	Verified	0.377101656396722	0.353049030147605	no	1710	0.324222718617288	1074	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	nicotinamide nucleotide metabolic process	ATP-dependent NAD(P)H-hydrate dehydratase activity	cytoplasm
YGR004W	YGR004W	PEX31	hom	Verified	0.376546019236449	0.353255505045497	no	1711	0.320016366879371	1075	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p	peroxisome organization	molecular_function	integral to membrane|integral to peroxisomal membrane
YNL155W	YNL155W	YNL155W	hom	Verified	0.376404502154622	0.353308099731314	no	1712	0.338213641946642	1178	NA	FT		NUCLEUS		Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YNL047C	YNL047C	SLM2	hom	Verified	0.376293870777312	0.353349217726344	no	1713	0.328590962194872	1097	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol binding	plasma membrane
YOR291W	YOR291W	YPK9	hom	Verified	0.376140651486612	0.35340616705605	no	1714	0.341568800588686	1132	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YMR228W	YMR228W	MTF1	hom	Verified	0.375906754215445	0.353493109519406	no	1715	0.338488328907373	1149	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation	transcription initiation from mitochondrial promoter	mitochondrial RNA polymerase binding promoter specificity activity	mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix|mitochondrial intermembrane space
YNL219C	YNL219C	ALG9	hom	Verified	0.37587561569477	0.353504684663342	no	1716	0.363717484525652	1190	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation	dolichol-linked oligosaccharide biosynthetic process|protein glycosylation	mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YML116W	YML116W	ATR1	hom	Verified	0.375523761486057	0.353635489085156	no	1717	0.318290077144399	1060	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	borate transport|drug transmembrane transport	drug transmembrane transporter activity|borate transmembrane transporter activity	integral to membrane|plasma membrane|vacuole
YCL021W-A_p	YCL021W-A	YCL021W-A	hom	Uncharacterized	0.375350087971735	0.35370005987931	no	1718	0.339414905403213	1139	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGR235C	YGR235C	MOS2	hom	Verified	0.375306127137922	0.353716404927189	no	1719	0.376162644410609	1260	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YOR296W_p	YOR296W	YOR296W	hom	Uncharacterized	0.374990840324611	0.353833639405077	no	1720	0.328666498714607	1109	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene	biological_process	molecular_function	cytoplasm
YGL218W_d	YGL218W	YGL218W	hom	Dubious	0.374535630431108	0.354002926546541	no	1721	0.383007313816826	1251	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YDR181C	YDR181C	SAS4	hom	Verified	0.374104249646798	0.354163378564076	no	1722	0.392972796873294	1301	NA	FT	CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p	chromatin silencing at telomere	acetyltransferase activity|histone acetyltransferase activity	nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YHL036W	YHL036W	MUP3	hom	Verified	0.373926234183081	0.354229598938504	no	1723	0.366207945713961	1226	NA					Low affinity methionine permease, similar to Mup1p	amino acid transport	L-methionine transmembrane transporter activity	integral to membrane|membrane
YAL016C-B_d	YAL016C-B	YAL016C-B	hom	Dubious	0.373133364678867	0.3545245937704	no	1724	0.334577413529386	1138	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL295W_p	YNL295W	YNL295W	hom	Uncharacterized	0.373033302552756	0.354561829066589	no	1725	0.328144672597717	1120	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKL205W	YKL205W	LOS1	hom	Verified	0.373030760333499	0.354562775099842	no	1726	0.365070501499129	1216	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS|MITOCHONDRION		Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus	tRNA binding|Ran GTPase binding	mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YIL050W	YIL050W	PCL7	hom	Verified	0.372805093858582	0.354646755690566	no	1727	0.299425169126999	1014	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated	regulation of glycogen catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of protein stability|regulation of glycogen biosynthetic process	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YIL024C_p	YIL024C	YIL024C	hom	Uncharacterized	0.372475241549734	0.354769521201531	no	1728	0.352096850713515	1192	NA					Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p	biological_process	molecular_function	cellular_component
YLL027W	YLL027W	ISA1	hom	Verified	0.371310233786179	0.355203238243254	no	1729	0.369707935577081	1244	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins	biotin biosynthetic process|iron-sulfur cluster assembly	iron-sulfur cluster binding|iron ion binding	mitochondrial matrix
YBL005W	YBL005W	PDR3	hom	Verified	0.370805424587792	0.355391230360845	no	1730	0.34647613311165	1176	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YDL227C	YDL227C	HO	hom	Verified	0.370693054855508	0.355433081900346	no	1731	0.332378027057173	1119	NA	FT		NUCLEUS		Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p	mating type switching|gene conversion at mating-type locus, DNA double-strand break formation	endonuclease activity	nucleus
YIL160C	YIL160C	POT1	hom	Verified	0.370593618167566	0.355470118046711	no	1732	0.346160435963924	1153	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids	fatty acid beta-oxidation	mRNA binding|acetyl-CoA C-acyltransferase activity	peroxisomal matrix|peroxisome
YMR224C	YMR224C	MRE11	hom	Verified	0.370435426494638	0.355529040862345	no	1733	0.364694145758804	1212	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress	DNA repair|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|base-excision repair|ascospore formation|meiotic DNA double-strand break processing|double-strand break repair via break-induced replication|regulation of transcription during meiosis	3'-5' exonuclease activity|protein complex scaffold|double-stranded telomeric DNA binding|adenylate kinase activity|telomeric DNA binding|single-stranded telomeric DNA binding|endodeoxyribonuclease activity|G-quadruplex DNA binding|endonuclease activity	mitochondrion|nucleus|Mre11 complex
YEL012W	YEL012W	UBC8	hom	Verified	0.370268393784243	0.355591260512017	no	1734	0.351402920058161	1145	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS			Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YOR015W_d	YOR015W	YOR015W	hom	Dubious	0.369945425833314	0.355711576918795	no	1735	0.34824402016303	1144	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL007C-A_p	YGL007C-A	YGL007C-A	hom	Uncharacterized	0.369376768392152	0.355923455844848	no	1736	0.355965181501112	1190	NA					Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding	biological_process	molecular_function	cellular_component
YGL062W	YGL062W	PYC1	hom	Verified	0.368941408117293	0.356085698997157	no	1737	0.35351289875063	1206	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication	NADPH regeneration|gluconeogenesis	pyruvate carboxylase activity	cytosol
YGL015C_p	YGL015C	YGL015C	hom	Uncharacterized	0.368242062221351	0.35634637466415	no	1738	0.344748535540121	1144	NA					Putative protein of unknown function; null mutants accumulate cargo in the Golgi	biological_process	molecular_function	cellular_component
YML012C-A_d	YML012C-A	YML012C-A	hom	Dubious	0.367705696499291	0.35654634625569	no	1739	0.361460226365025	1212	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1	Unknown	Unknown	Unknown
YDR506C	YDR506C	GMC1	hom	Verified	0.367460238470095	0.356637872780394	no	1740	0.346331499733258	1146	NA	FT	CELL CYCLE|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS			Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein	meiosis|synaptonemal complex organization	molecular_function	cellular_component
YDR153C	YDR153C	ENT5	hom	Verified	0.36716459297769	0.356748124193776	no	1741	0.343690494345128	1143	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin	late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|Golgi to endosome transport	clathrin binding|phosphatidylinositol-3,5-bisphosphate binding	endosome|clathrin vesicle coat|cytoplasm
YPR151C	YPR151C	SUE1	hom	Verified	0.367047539044533	0.356791778975804	no	1742	0.338556605295261	1129	NA	FT	PROTEOLYSIS	MITOCHONDRION		Mitochondrial protein required for degradation of unstable forms of cytochrome c	protein catabolic process	molecular_function	mitochondrial envelope
YIL052C	YIL052C	RPL34B	hom	Verified	0.366457132530983	0.357011997230633	no	1743	0.375221501461178	1254	NA	FF|FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR291C	YBR291C	CTP1	hom	Verified	0.36633471989409	0.357057662410831	no	1744	0.365277848723008	1241	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family	mitochondrial citrate transport|transmembrane transport	tricarboxylate secondary active transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YJR137C	YJR137C	MET5	hom	Verified	0.365896560737694	0.357221131406589	no	1745	0.31661852489272	1072	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS			Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine	fungal-type cell wall organization|sulfate assimilation	sulfite reductase (NADPH) activity	sulfite reductase complex (NADPH)|cytoplasm
YPL270W	YPL270W	MDL2	hom	Verified	0.365719597805792	0.357287160402438	no	1746	0.359162437794809	1217	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis	oligopeptide transport|oligopeptide export from mitochondrion	oligopeptide-transporting ATPase activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDR094W_d	YDR094W	YDR094W	hom	Dubious	0.365544810821497	0.357352381696469	no	1747	0.337362640550919	1120	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2	Unknown	Unknown	Unknown
YOR300W_d	YOR300W	YOR300W	hom	Dubious	0.365366225158554	0.357419024761347	no	1748	0.347986279494444	1165	NA					Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7	Unknown	Unknown	Unknown
YER014W	YER014W	HEM14	hom	Verified	0.365295296328984	0.357445494579813	no	1749	0.372485994150573	1217	NA	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides	heme biosynthetic process	oxygen-dependent protoporphyrinogen oxidase activity	mitochondrion|mitochondrial inner membrane
YOL013W-B_d	YOL013W-B	YOL013W-B	hom	Dubious	0.36487776515981	0.357601326278648	no	1750	0.344591458484794	1160	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element	Unknown	Unknown	Unknown
YCR046C	YCR046C	IMG1	hom	Verified	0.364381867096842	0.357786437047028	no	1751	0.353866854408974	1173	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YNL215W	YNL215W	IES2	hom	Verified	0.363904940211525	0.357964497737207	no	1752	0.366426056223927	1210	NA	FT		NUCLEUS		Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YBR238C	YBR238C	YBR238C	hom	Verified	0.363664173331676	0.358054399812408	no	1753	0.386189621151389	1274	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span	aerobic respiration	molecular_function	mitochondrion|integral to mitochondrial membrane|cytoplasm
YDR006C	YDR006C	SOK1	hom	Verified	0.363396791810209	0.358154248989277	no	1754	0.345205575754254	1156	NA	FT	SIGNALING	NUCLEUS		Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13	cAMP-mediated signaling	molecular_function	nucleus
YEL040W	YEL040W	UTR2	hom	Verified	0.362490954245679	0.358492591020659	no	1755	0.3504827470363	1187	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|CYTOSKELETON		Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck	cell wall chitin metabolic process|fungal-type cell wall organization	transferase activity, transferring glycosyl groups	cellular bud neck septin ring|fungal-type cell wall
YHR060W	YHR060W	VMA22	hom	Verified	0.361611593874263	0.358821149771854	no	1756	0.367694154429907	1218	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)	vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification	unfolded protein binding	extrinsic to endoplasmic reticulum membrane
YPR200C	YPR200C	ARR2	hom	Verified	0.36160520869087	0.358823535874542	no	1757	0.351789621374067	1172	NA					Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p	response to arsenic-containing substance	arsenate reductase activity	cellular_component
YML079W_p	YML079W	YML079W	hom	Uncharacterized	0.361454432393321	0.358879881625072	no	1758	0.361780216803889	1182	NA	FT		NUCLEUS		Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YER011W	YER011W	TIR1	hom	Verified	0.361056743403114	0.359028514439136	no	1759	0.331772008320763	1102	NA					Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking	response to stress	structural constituent of cell wall	fungal-type cell wall
YMR104C	YMR104C	YPK2	hom	Verified	0.360655459980961	0.359178512274631	no	1760	0.323016594541582	1086	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication	eisosome assembly|protein phosphorylation	protein kinase activity	nucleus|cytoplasm
YOR058C	YOR058C	ASE1	hom	Verified	0.360580409186878	0.359206568315175	no	1761	0.334177051571876	1122	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress	cytokinesis, completion of separation|mitotic anaphase B|microtubule bundle formation|spindle pole body separation|spindle midzone assembly|mitotic spindle stabilization|mitotic spindle elongation	microtubule binding	spindle midzone|nuclear microtubule|spindle
YPR133W-A	YPR133W-A	TOM5	hom	Verified	0.360325752206246	0.359301771721165	no	1762	0.3564630938812	1193	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore	mitochondrial outer membrane translocase complex assembly|protein targeting to mitochondrion	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YGL230C_p	YGL230C	YGL230C	hom	Uncharacterized	0.360301981201876	0.359310658947119	no	1763	0.349007851353571	1174	NA					Putative protein of unknown function; non-essential gene	biological_process	molecular_function	cellular_component
YAL030W	YAL030W	SNC1	hom	Verified	0.360257481261448	0.359327296270615	no	1764	0.348569918227874	1172	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication	endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion	SNAP receptor activity	SNARE complex|trans-Golgi network|endosome|transport vesicle membrane|plasma membrane|cellular bud neck
YGR017W_p	YGR017W	YGR017W	hom	Uncharacterized	0.359783101640442	0.359504670544687	no	1765	0.339396168166764	1124	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YKL220C	YKL220C	FRE2	hom	Verified	0.359469132846271	0.359622082600299	no	1766	0.33861069188496	1134	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YBR207W	YBR207W	FTH1	hom	Verified	0.359384714515586	0.359653654016986	no	1767	0.321600963979606	1128	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS			Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress	endocytosis|high-affinity iron ion transport	iron ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YER072W	YER072W	VTC1	hom	Verified	0.358745695622694	0.359892670271828	no	1768	0.364177981314196	1192	NA	FT	MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress	polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic	mRNA binding	integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex|intrinsic to vacuolar membrane
YLL015W	YLL015W	BPT1	hom	Verified	0.358448619481635	0.360003806193975	no	1769	0.321833198258971	1067	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p	cadmium ion transport|bilirubin transport	bilirubin transmembrane transporter activity|cadmium ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YKL176C	YKL176C	LST4	hom	Verified	0.358344738593377	0.360042670735818	no	1770	0.380728414318129	1267	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface	intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport	protein transporter activity	vesicle coat
YNR002C	YNR002C	ATO2	hom	Verified	0.357726726358388	0.360273915079198	no	1771	0.335742913827345	1113	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication	ammonium transport|nitrogen utilization	ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YHL016C	YHL016C	DUR3	hom	Verified	0.357050895474087	0.360526852204868	no	1772	0.341849128962208	1141	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway	urea transport|spermidine transport|putrescine transport|urea catabolic process	urea transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity	integral to membrane|plasma membrane
YFL003C	YFL003C	MSH4	hom	Verified	0.356666266486754	0.360670831087208	no	1773	0.343657310235506	1141	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein	reciprocal meiotic recombination	DNA binding	nuclear chromosome
YGR018C_p	YGR018C	YGR018C	hom	Uncharacterized	0.356445969667709	0.360753304102038	no	1774	0.346757235000111	1143	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W	biological_process	molecular_function	cellular_component
YLR190W	YLR190W	MMR1	hom	Verified	0.356359712264878	0.360785598244186	no	1775	0.323963290418789	1065	NA	FT	CELL CYCLE|CELL DIVISION|MITOCHONDRION ORGANIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH		Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p	mitochondrion inheritance	molecular_function	mitochondrial outer membrane|incipient cellular bud site|mitochondrion|cellular bud|cellular bud neck
YGR069W_d	YGR069W	YGR069W	hom	Dubious	0.356295709438887	0.360809561076741	no	1776	0.371390703296754	1231	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR059C	YDR059C	UBC5	hom	Verified	0.356218679851349	0.360838401888932	no	1777	0.362501245237008	1200	NA					Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication	protein polyubiquitination|response to stress	ubiquitin-protein ligase activity	proteasome complex
YLL033W	YLL033W	IRC19	hom	Verified	0.355406508705963	0.361142536751469	no	1778	0.337331733879273	1156	NA					Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci	mitotic recombination|ascospore formation	molecular_function	cellular_component
YKL113C	YKL113C	RAD27	hom	Verified	0.35501372446023	0.361289654726449	no	1779	0.379223077880608	1262	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family	double-strand break repair via nonhomologous end joining|replicative cell aging|DNA replication, removal of RNA primer|base-excision repair, base-free sugar-phosphate removal|gene conversion at mating-type locus, DNA repair synthesis	5'-3' exonuclease activity|5'-flap endonuclease activity	mitochondrion|nucleus
YDR032C	YDR032C	PST2	hom	Verified	0.354533562944433	0.361469527867019	no	1780	0.340644020096334	1164	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|membrane raft|plasma membrane|cytoplasm
YOL153C	YOL153C	YOL153C	hom	pseudogene	0.353128490359522	0.361996057408626	no	1781	0.338668381853039	1156	NA					Hypothetical protein	biological_process	molecular_function	cellular_component
YDR194C	YDR194C	MSS116	hom	Verified	0.353068865246031	0.362018406797588	no	1782	0.374228124124593	1214	NA	FT	RNA PROCESSING|TRANSLATION	MITOCHONDRION		DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing	RNA folding|Group I intron splicing|Group II intron splicing	RNA binding|RNA strand annealing activity|ATP-dependent RNA helicase activity	mitochondrion|mitochondrial matrix
YGL149W_d	YGL149W	YGL149W	hom	Dubious	0.35250522028371	0.362229702093185	no	1783	0.3536121979741	1145	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.	Unknown	Unknown	Unknown
YCR020C-A	YCR020C-A	MAK31	hom	Verified	0.352450793042235	0.362250107622011	no	1784	0.346022075413954	1148	NA					Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex
YDR065W	YDR065W	RRG1	hom	Verified	0.352331549086431	0.362294815205533	no	1785	0.356541856376108	1189	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	mitochondrial genome maintenance|vacuolar acidification	molecular_function	mitochondrion
YBL072C	YBL072C	RPS8A	hom	Verified	0.352113633068421	0.362376522300379	no	1786	0.339731646968498	1177	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YER122C	YER122C	GLO3	hom	Verified	0.352075787170393	0.362390713169297	no	1787	0.365618518852989	1227	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p	retrograde vesicle-mediated transport, Golgi to ER|COPI coating of Golgi vesicle|ER to Golgi vesicle-mediated transport	ARF GTPase activator activity	COPI-coated vesicle|endoplasmic reticulum-Golgi intermediate compartment|COPI vesicle coat
YPR119W	YPR119W	CLB2	hom	Verified	0.351918417892007	0.362449723092577	no	1788	0.372719726128506	1250	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|spindle pole body|cellular bud neck|spindle|cytoplasm
YGL256W	YGL256W	ADH4	hom	Verified	0.351817115177149	0.362487711050583	no	1789	0.353191877066055	1209	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency	fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	mitochondrion
YGL070C	YGL070C	RPB9	hom	Verified	0.351143754647381	0.362740251919781	no	1790	0.38963636092523	1296	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE	NUCLEUS	RNA POL II, HOLOENZYME	RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription	transcription initiation from RNA polymerase II promoter|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|response to DNA damage stimulus|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity	DNA-directed RNA polymerase II, core complex
YNL286W	YNL286W	CUS2	hom	Verified	0.350700348326425	0.362906582103149	no	1791	0.366078586854427	1208	NA	FT	RNA PROCESSING	NUCLEUS		Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)	mRNA splicing, via spliceosome	RNA binding	U2 snRNP
YGR092W	YGR092W	DBF2	hom	Verified	0.350656254137558	0.362923124090445	no	1792	0.426392251506719	1413	NA	FF|FT	CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS	SITE OF POLARIZED GROWTH|CYTOSKELETON		Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis	nuclear division|protein phosphorylation|vacuolar acidification	protein serine/threonine kinase activity|protein kinase activity	spindle pole body|cellular bud neck
YGL263W	YGL263W	COS12	hom	Verified	0.350433948573332	0.363006526181518	no	1793	0.345869440178605	1152	NA					Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	integral to membrane
YOL154W	YOL154W	ZPS1	hom	Verified	0.349268937232673	0.363443708145306	no	1794	0.345096600407235	1137	NA					Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH	biological_process	molecular_function	fungal-type cell wall|fungal-type vacuole
YML119W_p	YML119W	YML119W	hom	Uncharacterized	0.349015075678205	0.363538995818163	no	1795	0.365206532017231	1198	NA					Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate	biological_process	molecular_function	cellular_component
YCR003W	YCR003W	MRPL32	hom	Verified	0.348754440852959	0.36363683464177	no	1796	0.372222542549652	1235	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit
YNL335W_p	YNL335W	DDI3	hom	Uncharacterized	0.347770503281838	0.364006271746138	no	1797	0.364380370187341	1225	NA					Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants	biological_process	molecular_function	cellular_component
YGR036C	YGR036C	CAX4	hom	Verified	0.347730993769229	0.364021108947666	no	1798	0.380271818065441	1242	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation	lipid biosynthetic process|protein N-linked glycosylation	dolichyldiphosphatase activity	integral to endoplasmic reticulum membrane|integral to membrane
YDL036C	YDL036C	PUS9	hom	Verified	0.347324284746506	0.364173854232427	no	1799	0.350343082549808	1155	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|nucleus|cytoplasm
YMR245W_d	YMR245W	YMR245W	hom	Dubious	0.346760075788065	0.364385786555784	no	1800	0.420256110064894	1383	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR008C_d	YDR008C	YDR008C	hom	Dubious	0.346636082440768	0.364432367409887	no	1801	0.446210721895808	1466	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR406C-A_p	YLR406C-A	YLR406C-A	hom	Uncharacterized	0.346403176046148	0.364519869280459	no	1802	0.364471123625144	1197	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR050W-A_p	YHR050W-A	YHR050W-A	hom	Uncharacterized	0.344576727256763	0.365206302194914	no	1803	0.368449370301486	1233	NA					Protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YBR263W	YBR263W	SHM1	hom	Verified	0.344294564960603	0.365312385632383	no	1804	0.326222938041071	1094	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine	serine family amino acid biosynthetic process|one-carbon metabolic process	glycine hydroxymethyltransferase activity	mitochondrion
YDL073W_p	YDL073W	YDL073W	hom	Uncharacterized	0.344088561085353	0.365389842600319	no	1805	0.390531143227187	1337	NA					Putative protein of unknown function; YDL073W is not an essential gene	biological_process	molecular_function	cellular_component
YDL226C	YDL226C	GCS1	hom	Verified	0.341791455136741	0.366253920282428	no	1806	0.390821136936819	1305	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	MITOCHONDRION|GOLGI APPARATUS|CYTOSKELETON		ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p	retrograde vesicle-mediated transport, Golgi to ER|Golgi to plasma membrane protein transport|actin filament reorganization involved in cell cycle|ER to Golgi vesicle-mediated transport	actin binding|ARF GTPase activator activity|GTPase activator activity	endosome|trans-Golgi network|endoplasmic reticulum-Golgi intermediate compartment|cytoskeleton
YGL210W	YGL210W	YPT32	hom	Verified	0.340665396262094	0.366677745901447	no	1807	0.343442774312891	1138	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication	early endosome to Golgi transport|vesicle-mediated transport|exocytosis	GTPase activity	endosome|mitochondrial outer membrane|Golgi apparatus
YPR074C	YPR074C	TKL1	hom	Verified	0.340294884714055	0.366817234478329	no	1808	0.403033414713484	1316	NA	FF|FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication	pentose-phosphate shunt	transketolase activity	cytoplasm
YNL314W	YNL314W	DAL82	hom	Verified	0.33833618323687	0.367554929751666	no	1809	0.372329210131462	1221	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain	allantoin catabolic process|nitrogen catabolite activation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YNL177C	YNL177C	MRPL22	hom	Verified	0.33793180965432	0.367707287798322	no	1810	0.378577925340214	1263	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YKL030W_d	YKL030W	YKL030W	hom	Dubious	0.337810590074361	0.367752964419884	no	1811	0.364266327071801	1180	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene MAE1	Unknown	Unknown	Unknown
YBR116C_d	YBR116C	YBR116C	hom	Dubious	0.337622598568722	0.36782380499954	no	1812	0.354791379870988	1153	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2	Unknown	Unknown	Unknown
YGR220C	YGR220C	MRPL9	hom	Verified	0.337462247638857	0.367884233372597	no	1813	0.339974180220184	1155	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	cytoplasmic translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YMR135W-A_d	YMR135W-A	YMR135W-A	hom	Dubious	0.336671216357025	0.368182381956802	no	1814	0.339657989287618	1125	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL152W	YPL152W	RRD2	hom	Verified	0.335605605049664	0.368584148354815	no	1815	0.348589294740331	1155	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION			Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress	mitotic spindle organization in nucleus|response to osmotic stress	peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity	protein phosphatase type 2A complex
YBL064C	YBL064C	PRX1	hom	Verified	0.33552944938508	0.368612866758128	no	1816	0.338306332665997	1139	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress	response to cadmium ion|cellular response to oxidative stress|cell redox homeostasis	thioredoxin peroxidase activity	mitochondrion
YIR018C-A_p	YIR018C-A	YIR018C-A	hom	Uncharacterized	0.335490785363104	0.368627447293568	no	1817	0.36040773581229	1208	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YLR385C	YLR385C	SWC7	hom	Verified	0.335201737950759	0.368736455551186	no	1818	0.360358010381182	1223	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin	chromatin remodeling	molecular_function	Swr1 complex|nucleus
YLR067C	YLR067C	PET309	hom	Verified	0.332911963166505	0.369600369378767	no	1819	0.373465645113457	1247	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)	positive regulation of mitochondrial translational initiation|RNA metabolic process|mitochondrial respiratory chain complex IV biogenesis|aerobic respiration	translation regulator activity	extrinsic to mitochondrial inner membrane|mitochondrion|integral to membrane|mitochondrial inner membrane
YNR030W	YNR030W	ALG12	hom	Verified	0.331750094487072	0.370038985406778	no	1820	0.399285086829325	1313	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation	dolichol-linked oligosaccharide biosynthetic process|protein glycosylation	alpha-1,6-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YGL147C	YGL147C	RPL9A	hom	Verified	0.331610837123709	0.370091567690757	no	1821	0.372060540257402	1247	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR401C	YLR401C	DUS3	hom	Verified	0.330989028558623	0.370326386431818	no	1822	0.322772417981883	1063	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	NUCLEUS		Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress	tRNA modification	tRNA dihydrouridine synthase activity	nucleus|cytoplasm
YEL047C	YEL047C	FRD1	hom	Verified	0.330851139472701	0.370378465184725	no	1823	0.368197010863111	1218	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication	cellular response to anoxia	fumarate reductase (NADH) activity	cytosol|mitochondrion|ribosome|plasma membrane
YLR207W	YLR207W	HRD3	hom	Verified	0.330131486833728	0.37065030632247	no	1824	0.358235640816586	1177	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events	ER-associated protein catabolic process	ubiquitin-protein ligase activity	Hrd1p ubiquitin ligase ERAD-M complex|luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YDL113C	YDL113C	ATG20	hom	Verified	0.329780571688534	0.370782884224732	no	1825	0.361465292052314	1202	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate	mitochondrion degradation|early endosome to Golgi transport|macroautophagy|CVT pathway	phosphatidylinositol-3-phosphate binding	endosome|pre-autophagosomal structure|extrinsic to membrane
YDR155C	YDR155C	CPR1	hom	Verified	0.329745456384021	0.370796151847719	no	1826	0.380760648193065	1266	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress	cellular protein metabolic process|ascospore formation|positive regulation of meiosis|histone deacetylation	peptidyl-prolyl cis-trans isomerase activity|cyclosporin A binding	histone deacetylase complex|mitochondrion|Set3 complex|nucleus
YDR112W_d	YDR112W	IRC2	hom	Dubious	0.329383352615874	0.370932974549027	no	1827	0.37146391832823	1200	NA					Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci	Unknown	Unknown	Unknown
YEL023C_p	YEL023C	YEL023C	hom	Uncharacterized	0.327926921682286	0.37148345885342	no	1828	0.376881903264979	1270	NA					Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene	biological_process	molecular_function	cellular_component
YOR179C	YOR179C	SYC1	hom	Verified	0.327920462615042	0.371485900760712	no	1829	0.371180100322731	1256	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication	termination of RNA polymerase II transcription, exosome-dependent|termination of RNA polymerase II transcription, poly(A)-coupled	RNA binding	mRNA cleavage and polyadenylation specificity factor complex|nucleus
YBR232C_d	YBR232C	YBR232C	hom	Dubious	0.327197729498771	0.371759169030771	no	1830	0.368262201648681	1241	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCL026C-A	YCL026C-A	FRM2	hom	Verified	0.326141764426866	0.372158549792292	no	1831	0.350653795431364	1189	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin	cellular response to oxidative stress|negative regulation of fatty acid metabolic process	oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor	nucleus|cytoplasm
YLL041C	YLL041C	SDH2	hom	Verified	0.325738379734691	0.372311151860705	no	1832	0.364109518041669	1179	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain	mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial membrane
YKL051W	YKL051W	SFK1	hom	Verified	0.320573196493629	0.374266926243921	no	1833	0.347724313878411	1130	NA	FT	LIPID METABOLISM|SIGNALING|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane	vacuole organization|inositol lipid-mediated signaling|actin cytoskeleton organization	molecular_function	integral to membrane|plasma membrane
YGL096W	YGL096W	TOS8	hom	Verified	0.318740661309389	0.374961589148681	no	1834	0.367459916807809	1221	NA	FT		NUCLEUS|CHROMOSOME		Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication	biological_process	chromatin binding|sequence-specific DNA binding	nuclear chromatin
YKR095W	YKR095W	MLP1	hom	Verified	0.318012087754984	0.375237883911333	no	1835	0.376378050081992	1220	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs	protein localization to nuclear pore|poly(A)+ mRNA export from nucleus|protein import into nucleus|transcriptional activation by promoter-terminator looping|nuclear retention of unspliced pre-mRNA at the site of transcription|telomere tethering at nuclear periphery	ribonucleoprotein complex binding	nucleoplasm|nuclear envelope|integral to membrane|ribonucleoprotein complex|spindle pole body
YHL039W	YHL039W	EFM1	hom	Verified	0.31706432583408	0.375597396613419	no	1836	0.376892446700504	1252	NA					Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	cytoplasm
YER179W	YER179W	DMC1	hom	Verified	0.316872623798445	0.375670127724239	no	1837	0.358169325379369	1162	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p	meiosis|reciprocal meiotic recombination|meiotic joint molecule formation	double-stranded DNA binding|single-stranded DNA binding	condensed nuclear chromosome|nucleus
YOL162W_p	YOL162W	YOL162W	hom	Uncharacterized	0.310710017912247	0.378010540386574	no	1838	0.370084090112277	1227	NA					Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family	transmembrane transport	transmembrane transporter activity	integral to membrane|membrane
YNR023W	YNR023W	SNF12	hom	Verified	0.310491312631055	0.378093682400252	no	1839	0.433339096203536	1908	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive	positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex
YOR187W	YOR187W	TUF1	hom	Verified	0.30978649675867	0.378361660423077	no	1840	0.445291372385048	1451	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans	mitochondrial translational elongation|mitochondrial translation	GTPase activity|translation elongation factor activity	mitochondrion|mitochondrial matrix
YDR491C_d	YDR491C	YDR491C	hom	Dubious	0.309135407545005	0.378609263033622	no	1841	0.353348278941261	1159	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL146C	YIL146C	ATG32	hom	Verified	0.308953928705112	0.37867828647827	no	1842	0.354367902171226	1179	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane	fungal-type cell wall organization|mitochondrion degradation	molecular_function	integral to mitochondrial outer membrane
YEL006W	YEL006W	YEA6	hom	Verified	0.307917121910247	0.379072698486422	no	1843	0.382565243243079	1288	NA	FT		MITOCHONDRION		Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog	transport|NAD transmembrane transport	transporter activity|NAD transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YBR292C_d	YBR292C	YBR292C	hom	Dubious	0.307549771154919	0.379212472740857	no	1844	0.376045219898879	1270	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene	Unknown	Unknown	Unknown
YFL036W	YFL036W	RPO41	hom	Verified	0.307299600254683	0.37930766996479	no	1845	0.384603666811121	1261	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation	transcription from mitochondrial promoter|mitochondrial genome maintenance	DNA-directed RNA polymerase activity	mitochondrial nucleoid|mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix
YML116W-A_d	YML116W-A	YML116W-A	hom	Dubious	0.306818070084259	0.379490926642847	no	1846	0.355376988302658	1172	NA					Putative protein of unknown function	Unknown	Unknown	Unknown
YFR014C	YFR014C	CMK1	hom	Verified	0.306356748264458	0.379666517994399	no	1847	0.366140534968583	1198	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication	signal transduction|protein phosphorylation	protein kinase activity|calmodulin-dependent protein kinase activity	cytoplasm
YLR216C	YLR216C	CPR6	hom	Verified	0.306223189338398	0.379717358707256	no	1848	0.353474219926787	1161	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress	protein folding|protein refolding	unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity	cytoplasm
YOL099C_d	YOL099C	YOL099C	hom	Dubious	0.304579033263575	0.380343395380228	no	1849	0.343847849164352	1156	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes	Unknown	Unknown	Unknown
YNL070W	YNL070W	TOM7	hom	Verified	0.303539722619391	0.380739290094764	no	1850	0.399872471493387	1325	NA	FF|FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex	protein import into mitochondrial matrix|protein import into mitochondrial outer membrane	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YDL186W_p	YDL186W	YDL186W	hom	Uncharacterized	0.303479146266659	0.380762368724651	no	1851	0.377506573702734	1249	NA					Putative protein of unknown function; YDL186W is not an essential gene	biological_process	molecular_function	cellular_component
YPL031C	YPL031C	PHO85	hom	Verified	0.303456987378472	0.380770811015687	no	1852	0.418451621618261	1381	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES A	NUCLEUS		Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle	regulation of transcription involved in G1/S phase of mitotic cell cycle|negative regulation of calcium-mediated signaling|regulation of protein stability|regulation of protein localization|protein phosphorylation|response to DNA damage stimulus|negative regulation of phosphate metabolic process|fungal-type cell wall organization|regulation of establishment or maintenance of cell polarity|negative regulation of glycogen biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of macroautophagy|negative regulation of macroautophagy	protein kinase activity|cyclin-dependent protein kinase activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YDL039C	YDL039C	PRM7	hom	Verified	0.303223192991592	0.380859887546776	no	1853	0.379627017946705	1229	NA					Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements	conjugation with cellular fusion	molecular_function	integral to membrane
YBR164C	YBR164C	ARL1	hom	Verified	0.301882372092057	0.381370867123739	no	1854	0.410261220878329	1370	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|VACUOLAR TRANSPORT	GOLGI APPARATUS		Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor	Golgi to plasma membrane protein transport|vesicle-mediated transport|protein targeting to vacuole	GTPase activity	trans-Golgi network|cytosol|Golgi apparatus
YOR033C	YOR033C	EXO1	hom	Verified	0.301037349685878	0.381693006906428	no	1855	0.384699328308556	1296	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress	mismatch repair|telomeric 3' overhang formation|DNA double-strand break processing|meiotic DNA double-strand break processing|telomere maintenance|gene conversion at mating-type locus, DNA double-strand break processing	5'-3' exonuclease activity|5'-flap endonuclease activity	nucleus
YLL024C	YLL024C	SSA2	hom	Verified	0.300542662649097	0.381881629744839	no	1856	0.373466522122393	1227	NA	FT	PROTEIN LOCALIZATION	MITOCHONDRION		ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity|ATP binding	cytosol|fungal-type vacuole membrane|mitochondrion|fungal-type cell wall|plasma membrane|polysome|chaperonin-containing T-complex|cytoplasm
YLR358C_p	YLR358C	YLR358C	hom	Uncharacterized	0.300098491495224	0.38205101490985	no	1857	0.34129083795681	1132	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W	biological_process	molecular_function	cellular_component
YOR137C	YOR137C	SIA1	hom	Verified	0.300060139406794	0.382065641580987	no	1858	0.360145621044689	1184	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose	proton transport	molecular_function	cellular_component
YBR197C	YBR197C	YBR197C	hom	Verified	0.299817495471582	0.382158184719585	no	1859	0.385270533795112	1281	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YOR093C_p	YOR093C	YOR093C	hom	Uncharacterized	0.299395284067958	0.382319230006512	no	1860	0.349281758867789	1157	NA	FT		NUCLEUS		Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents	biological_process	molecular_function	integral to membrane
YBR259W	YBR259W	YBR259W	hom	Verified	0.29828145234587	0.382744179611871	no	1861	0.383944251795656	1257	NA					Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress	biological_process	molecular_function	cellular_component
YMR306C-A_d	YMR306C-A	YMR306C-A	hom	Dubious	0.297981710603427	0.382858561356219	no	1862	0.372119217297004	1222	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHL046C	YHL046C	PAU13	hom	Verified	0.297351940588885	0.383098915486505	no	1863	0.370978179435675	1222	NA					Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock	biological_process	molecular_function	cellular_component
YNL162W-A_p	YNL162W-A	YNL162W-A	hom	Uncharacterized	0.296741910264556	0.383331778808985	no	1864	0.376743441985008	1214	NA	FT		NUCLEUS		Putative protein of unknown function; identified by homology	biological_process	molecular_function	nucleus|cytoplasm
YBR036C	YBR036C	CSG2	hom	Verified	0.296289582343148	0.383504470534539	no	1865	0.392434756892788	1283	NA	FF|FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress	cellular calcium ion homeostasis|glycosphingolipid biosynthetic process	enzyme regulator activity	integral to endoplasmic reticulum membrane|integral to membrane
YHR071W	YHR071W	PCL5	hom	Verified	0.296253304403519	0.383518321887512	no	1866	0.354068556330633	1197	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity	negative regulation of sequence-specific DNA binding transcription factor activity|regulation of protein stability|negative regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YGL154C	YGL154C	LYS5	hom	Verified	0.296089838016028	0.383580737163574	no	1867	0.368390417303946	1211	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine	lysine biosynthetic process via aminoadipic acid|protein-cofactor linkage	holo-[acyl-carrier-protein] synthase activity	cytoplasm
YER028C	YER028C	MIG3	hom	Verified	0.295692216127402	0.383732571075081	no	1868	0.381205980792353	1281	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication	cellular response to UV|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|response to DNA damage stimulus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nuclear chromatin
YOR324C	YOR324C	FRT1	hom	Verified	0.294144443466434	0.384323765623607	no	1869	0.385479732527836	1253	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication	response to stress	molecular_function	endoplasmic reticulum
YJR145C	YJR145C	RPS4A	hom	Verified	0.294061394760167	0.384355494920973	no	1870	0.379770807478251	1265	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasm|90S preribosome
YLR369W	YLR369W	SSQ1	hom	Verified	0.2929259983489	0.384789358119098	no	1871	0.379545691809762	1226	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia	iron-sulfur cluster assembly|intracellular sequestering of iron ion|protein maturation	unfolded protein binding	mitochondrion|mitochondrial matrix
YLL039C	YLL039C	UBI4	hom	Verified	0.292444043089964	0.384973568869214	no	1872	0.352981616862045	1178	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress	protein deubiquitination|ascospore formation|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress	ATP-dependent protein binding|protein tag	cytoplasm
YMR178W	YMR178W	YMR178W	hom	Verified	0.292369858238678	0.385001925773075	no	1873	0.369670990669354	1219	NA	FT	COFACTOR METABOLISM	NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YPL170W	YPL170W	DAP1	hom	Verified	0.292003894273317	0.385141823236424	no	1874	0.413302920803112	1359	NA	FT	LIPID METABOLISM			Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis	regulation of ergosterol biosynthetic process	heme binding	endosome|membrane
YDR024W_d	YDR024W	FYV1	hom	Dubious	0.291706675316328	0.38525545246942	no	1875	0.397797802921623	1339	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin	Unknown	Unknown	Unknown
YBR177C	YBR177C	EHT1	hom	Verified	0.291686783673775	0.385263057558562	no	1876	0.37702137672189	1239	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication	medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process|cellular lipid metabolic process	short-chain carboxylesterase activity|alcohol O-butanoyltransferase activity|serine hydrolase activity	mitochondrial outer membrane|mitochondrion|lipid particle
YDL101C	YDL101C	DUN1	hom	Verified	0.291164670211648	0.385462690802718	no	1877	0.390426819271207	1296	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair	protein phosphorylation|replication fork protection|cell cycle checkpoint|DNA damage checkpoint	protein kinase activity	nucleus
YNL157W	YNL157W	IGO1	hom	Verified	0.289304901092341	0.386174031040161	no	1878	0.338144246073704	1111	NA	FT		NUCLEUS		Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p	mRNA stabilization	molecular_function	nucleus|cytoplasmic mRNA processing body|cytoplasm
YLR200W	YLR200W	YKE2	hom	Verified	0.289204335956888	0.386212506975155	no	1879	0.41284704422169	1368	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin	protein folding|tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YOR343C_d	YOR343C	YOR343C	hom	Dubious	0.288468881608656	0.386493923712554	no	1880	0.378184629792774	1234	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL064C	YEL064C	AVT2	hom	Verified	0.287891290146477	0.386714977129738	no	1881	0.369941661572845	1239	NA	FT		ENDOPLASMIC RETICULUM		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	transport	transporter activity	integral to membrane|endoplasmic reticulum
YPR067W	YPR067W	ISA2	hom	Verified	0.287687848297748	0.386792846311014	no	1882	0.411030750806488	1369	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations	iron-sulfur cluster assembly|biotin biosynthetic process	iron ion binding	mitochondrion|mitochondrial intermembrane space
YLR387C	YLR387C	REH1	hom	Verified	0.286772650367157	0.387143202803536	no	1883	0.42683259135304	1404	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS		RIBOSOME	Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains	ribosomal large subunit biogenesis|budding cell bud growth	molecular_function	cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YJR049C	YJR049C	UTR1	hom	Verified	0.286632839739463	0.387196733276596	no	1884	0.403199558478859	1323	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM	NUCLEUS		ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication	cellular iron ion homeostasis|NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	nucleus|cytoplasm
YIR034C	YIR034C	LYS1	hom	Verified	0.286221917288765	0.387354079032531	no	1885	0.405104686203802	1345	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity	lysine biosynthetic process|lysine biosynthetic process via aminoadipic acid	saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|mRNA binding	cytoplasm
YDR147W	YDR147W	EKI1	hom	Verified	0.285629964174461	0.3875807755203	no	1886	0.400285268573452	1344	NA	FT	LIPID METABOLISM			Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolamine kinase activity|choline kinase activity	cytoplasm
YJL120W_d	YJL120W	YJL120W	hom	Dubious	0.284882887702295	0.387866933313581	no	1887	0.428393092209116	1407	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YBR085W	YBR085W	AAC3	hom	Verified	0.284045030423548	0.38818793595189	no	1888	0.380709954931968	1258	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication	heme biosynthetic process|heme transport|anaerobic respiration|transmembrane transport	ATP:ADP antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YPL123C	YPL123C	RNY1	hom	Verified	0.283834654520409	0.388268547868999	no	1889	0.376293299690415	1259	NA					Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity	cell morphogenesis|RNA catabolic process|apoptotic process	endoribonuclease activity	cytosol|extracellular region|vacuole
YBL002W	YBL002W	HTB2	hom	Verified	0.283787261113758	0.388286708756726	no	1890	0.378425229881666	1239	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation	chromatin assembly or disassembly	DNA binding	replication fork protection complex|nuclear nucleosome
YER111C	YER111C	SWI4	hom	Verified	0.282948240744042	0.388608257062433	no	1891	0.376775254328008	1250	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS|CHROMOSOME		DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	SBF transcription complex|nuclear chromatin
YDL079C	YDL079C	MRK1	hom	Verified	0.282939695246162	0.388611532453929	no	1892	0.386133218350299	1273	NA	FT	PROTEIN PHOSPHORYLATION			Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation	regulation of protein catabolic process|protein phosphorylation|response to stress	protein serine/threonine kinase activity	cellular_component
YBL091C	YBL091C	MAP2	hom	Verified	0.281854131531304	0.389027680924577	no	1893	0.39151702842646	1295	NA	FT	PROTEOLYSIS			Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p	protein initiator methionine removal involved in protein maturation	metalloaminopeptidase activity	cytoplasm
YOL086W-A	YOL086W-A	MHF1	hom	Verified	0.281400168005451	0.389201744635761	no	1894	0.373129822415997	1270	NA	FT	RESPONSE TO DNA DAMAGE			Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1	response to DNA damage stimulus	molecular_function	cellular_component
YDR382W	YDR382W	RPP2B	hom	Verified	0.281237804915193	0.389264005086516	no	1895	0.378885756620707	1251	NA	FT	TRANSLATION		RIBOSOME	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	translational elongation|cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR532C	YDR532C	KRE28	hom	Verified	0.28009892287141	0.389700805533891	no	1896	0.407670075461814	1328	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components	biological_process	molecular_function	chromosome, centromeric region|condensed nuclear chromosome kinetochore|spindle pole body
YIL103W	YIL103W	DPH1	hom	Verified	0.279153851292051	0.390063378827924	no	1897	0.376462475180534	1252	NA					Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	molecular_function	cytoplasm
YAL022C	YAL022C	FUN26	hom	Verified	0.279065406365754	0.390097315304144	no	1898	0.392408831803686	1281	NA					Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis	nucleoside transport|nicotinamide riboside transport|transmembrane transport	nicotinamide riboside transporter activity|nucleoside transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|intracellular|membrane
YPL141C	YPL141C	FRK1	hom	Verified	0.278156083059376	0.390446272813469	no	1899	0.39211423598419	1294	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication	protein phosphorylation	protein kinase activity	cytoplasm
YGR290W_d	YGR290W	YGR290W	hom	Dubious	0.277995821757419	0.390507783072137	no	1900	0.4039008252914	1330	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)	Unknown	Unknown	Unknown
YER064C	YER064C	VHR2	hom	Verified	0.277927991651216	0.390533817926598	no	1901	0.379259823913862	1253	NA	FT		NUCLEUS		Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	regulation of transcription, DNA-dependent	molecular_function	nucleus
YDL121C_p	YDL121C	YDL121C	hom	Uncharacterized	0.277755083984266	0.390600186339936	no	1902	0.387691904741249	1261	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein	biological_process	molecular_function	endoplasmic reticulum
YDR509W_d	YDR509W	YDR509W	hom	Dubious	0.277041160968927	0.390874250358334	no	1903	0.376247574658633	1270	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR132W-A	YHR132W-A	IGO2	hom	Verified	0.276778491535115	0.390975098745731	no	1904	0.39331900806463	1290	NA	FT		NUCLEUS		Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p	mRNA stabilization	molecular_function	nucleus|cytoplasm
YGR086C	YGR086C	PIL1	hom	Verified	0.276606387848325	0.39104117961196	no	1905	0.380170676661845	1276	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Primary protein component of eisosomes; eisosomes are large immobile cell cortex structures associated with endocytosis; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress	eisosome assembly|endocytosis|negative regulation of protein kinase activity|response to heat|protein localization	lipid binding	mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YPL176C	YPL176C	TRE1	hom	Verified	0.276350400287664	0.391139474317474	no	1906	0.384783998637122	1279	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	molecular_function	fungal-type vacuole
YDR150W	YDR150W	NUM1	hom	Verified	0.276307367170212	0.391155998958019	no	1907	0.410410264420226	1359	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex	mitochondrion inheritance|nuclear migration along microtubule|mitochondrial fission|microtubule cytoskeleton organization	tubulin binding	cell cortex|mitochondrion|cellular bud tip
YMR312W	YMR312W	ELP6	hom	Verified	0.275840397137974	0.391335327248125	no	1908	0.388309760339281	1282	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	protein urmylation|regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex
YOL143C	YOL143C	RIB4	hom	Verified	0.274578614876515	0.391819998952284	no	1909	0.417108731221619	1387	NA	FT		NUCLEUS		Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin	riboflavin biosynthetic process	6,7-dimethyl-8-ribityllumazine synthase activity	nucleus|cytoplasm
YDR497C	YDR497C	ITR1	hom	Verified	0.273960550536463	0.392057469145235	no	1910	0.383573702776965	1249	NA	FT		PLASMA MEMBRANE		Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress	myo-inositol transport|transmembrane transport	myo-inositol transmembrane transporter activity	integral to membrane|plasma membrane|membrane
YNL045W	YNL045W	LAP2	hom	Verified	0.272558506211111	0.392596305916594	no	1911	0.383055730025983	1286	NA	FT	KETONE METABOLISM|LIPID METABOLISM|PROTEOLYSIS	NUCLEUS		Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	cellular lipid metabolic process|protein catabolic process	aminopeptidase activity|leukotriene-A4 hydrolase activity|epoxide hydrolase activity	nucleus|cytoplasm
YHR109W	YHR109W	CTM1	hom	Verified	0.272067305493236	0.392785134027747	no	1912	0.379564761949508	1231	NA					Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth	peptidyl-lysine methylation	[cytochrome c]-lysine N-methyltransferase activity	cytosol
YML123C	YML123C	PHO84	hom	Verified	0.272042347616967	0.392794729045761	no	1913	0.410484374321916	1350	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity	phosphate ion transport|manganese ion transport|polyphosphate metabolic process	manganese ion transmembrane transporter activity|inorganic phosphate transmembrane transporter activity	integral to membrane|integral to plasma membrane
YJL075C_d	YJL075C	APQ13	hom	Dubious	0.272037888625716	0.392796443305104	no	1914	0.395873198986582	1287	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate	Unknown	Unknown	Unknown
YGL205W	YGL205W	POX1	hom	Verified	0.271261972291687	0.393094776002688	no	1915	0.37861246114828	1250	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix	fatty acid beta-oxidation using acyl-CoA oxidase|fatty acid beta-oxidation	acyl-CoA oxidase activity	peroxisomal matrix
YFR016C	YFR016C	YFR016C	hom	Verified	0.271213471243179	0.393113426297103	no	1916	0.371537663433962	1240	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene	biological_process	molecular_function	cellular bud|cytoplasm
YMR195W	YMR195W	ICY1	hom	Verified	0.271177790257869	0.393127147000023	no	1917	0.376878369876887	1241	NA					Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation	biological_process	molecular_function	fungal-type vacuole membrane
YOR322C	YOR322C	LDB19	hom	Verified	0.270949776797404	0.393214830026662	no	1918	0.421467066677011	1385	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION	GOLGI APPARATUS|PLASMA MEMBRANE		Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye	ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	cytosol|Golgi apparatus|plasma membrane|clathrin-coated vesicle|cytoplasm
YBR148W	YBR148W	YSW1	hom	Verified	0.270821072876864	0.39326432576572	no	1919	0.375012552848564	1251	NA	FT	MEMBRANE ORGANIZATION			Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane	ascospore-type prospore membrane assembly	molecular_function	prospore membrane
YNL202W	YNL202W	SPS19	hom	Verified	0.268884659858411	0.394009221025989	no	1920	0.409927759784981	1371	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate	fatty acid catabolic process|ascospore formation	2,4-dienoyl-CoA reductase (NADPH) activity	peroxisomal matrix
YGR136W	YGR136W	LSB1	hom	Verified	0.268726541624489	0.394070062780766	no	1921	0.368767474014649	1218	NA	FT		NUCLEUS		Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YMR204C	YMR204C	INP1	hom	Verified	0.267019286721487	0.394727155704359	no	1922	0.381782760378108	1245	NA	FT	PEROXISOME ORGANIZATION			Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane	peroxisome inheritance	molecular_function	peroxisome|extrinsic to intraperoxisomal membrane
YMR123W	YMR123W	PKR1	hom	Verified	0.266255267129086	0.395021310798349	no	1923	0.429661626461936	1411	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress	vacuolar proton-transporting V-type ATPase complex assembly	molecular_function	integral to endoplasmic reticulum membrane
YGL108C	YGL108C	YGL108C	hom	Verified	0.266200921169893	0.39504223681144	no	1924	0.394099478317185	1307	NA					Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cellular_component
YLR247C	YLR247C	IRC20	hom	Verified	0.26603103044151	0.395107655505895	no	1925	0.377920017490821	1264	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci	double-strand break repair via synthesis-dependent strand annealing	helicase activity	mitochondrion|nucleus
YNL254C	YNL254C	RTC4	hom	Verified	0.265008222974438	0.395501563606228	no	1926	0.37416471310308	1230	NA	FT		NUCLEUS		Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YLR179C	YLR179C	YLR179C	hom	Verified	0.264942139551891	0.395527017620573	no	1927	0.371625203420561	1234	NA	FT		NUCLEUS		Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YOL067C	YOL067C	RTG1	hom	Verified	0.263798806474057	0.395967477151618	no	1928	0.410895108204524	1345	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus	cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus|cytoplasm
YLL012W	YLL012W	YEH1	hom	Verified	0.262486143368511	0.396473333471698	no	1929	0.374727386158789	1246	NA	FT	LIPID METABOLISM			Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes	sterol metabolic process	sterol esterase activity	integral to membrane|lipid particle
YBR065C	YBR065C	ECM2	hom	Verified	0.25961887897685	0.397578886118028	no	1930	0.38341030622948	1259	NA	FT	RNA PROCESSING	NUCLEUS		Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p	mRNA splicing, via spliceosome	molecular_function	nucleus
YDR534C	YDR534C	FIT1	hom	Verified	0.259575017020114	0.397595804716773	no	1931	0.349769135231317	1192	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall	siderophore transport	molecular_function	fungal-type cell wall
YDR020C_p	YDR020C	DAS2	hom	Uncharacterized	0.258609236854841	0.397968377832188	no	1932	0.379870981025911	1259	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases	biological_process	molecular_function	nucleus|cytoplasm
YGL246C	YGL246C	RAI1	hom	Verified	0.258052737564161	0.398183103210476	no	1933	0.386782238905413	1266	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z	deadenylation-dependent decapping of nuclear-transcribed mRNA|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|termination of RNA polymerase II transcription, poly(A)-coupled|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	enzyme regulator activity|m7G(5')pppN diphosphatase activity	nucleus
YLR273C	YLR273C	PIG1	hom	Verified	0.25751834502251	0.398389327720264	no	1934	0.37527382878586	1236	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase	regulation of glycogen biosynthetic process	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex
YHL006C	YHL006C	SHU1	hom	Verified	0.257250533258169	0.398492688176195	no	1935	0.359418946854337	1243	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function	recombinational repair|maintenance of rDNA	molecular_function	nucleolus|Shu complex
YML003W_p	YML003W	YML003W	hom	Uncharacterized	0.256996525210091	0.398590727745098	no	1936	0.38551046695994	1278	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR028C	YLR028C	ADE16	hom	Verified	0.256917132930821	0.398621372122053	no	1937	0.399689626289685	1342	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine	ascospore formation|'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process|aerobic respiration	phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity	cytosol
YBR260C	YBR260C	RGD1	hom	Verified	0.256823151301708	0.398657648604313	no	1938	0.39009487607615	1283	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization	response to acid|osmosensory signaling pathway	Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding	cellular bud|mating projection tip|actin cortical patch
YBR186W	YBR186W	PCH2	hom	Verified	0.255552490609201	0.399148203690374	no	1939	0.373212074587048	1243	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation	meiotic recombination checkpoint|meiotic DNA double-strand break formation|reciprocal meiotic recombination	ATPase activity	nucleolus
YOR083W	YOR083W	WHI5	hom	Verified	0.254919527982669	0.399392626638719	no	1940	0.393436289305657	1290	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1	negative regulation of transcription involved in G1/S phase of mitotic cell cycle|regulation of cell size	RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	SBF transcription complex|nucleus|cytoplasm
YML062C	YML062C	MFT1	hom	Verified	0.254487272777037	0.399559567682031	no	1941	0.404278752372812	1341	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION	NUCLEUS		Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance	mRNA export from nucleus|DNA recombination|transcription elongation from RNA polymerase II promoter	protein complex scaffold|nucleic acid binding	THO complex part of transcription export complex|nucleoplasmic THO complex
YMR129W	YMR129W	POM152	hom	Verified	0.254234101046128	0.399657353525967	no	1942	0.355763883630517	1172	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	NUCLEAR PORE	Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210	nucleocytoplasmic transport|nuclear pore organization|protein import into nucleus|spindle pole body duplication associated with nuclear envelope	protein anchor|structural constituent of nuclear pore	mitochondrion|integral to membrane|nuclear pore transmembrane ring|nuclear envelope lumen|nuclear pore
YHL012W_p	YHL012W	YHL012W	hom	Uncharacterized	0.254044602220666	0.399730550266138	no	1943	0.37727507167266	1257	NA					Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YAL017W	YAL017W	PSK1	hom	Verified	0.253336123793962	0.400004241792641	no	1944	0.385931355395983	1284	NA	FT	SIGNALING|TRANSLATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY			PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication	regulation of (1->6)-beta-D-glucan biosynthetic process|negative regulation of glycogen biosynthetic process|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YMR184W	YMR184W	ADD37	hom	Verified	0.252717297471499	0.40024334011296	no	1945	0.395726880917225	1307	NA	FT	PROTEOLYSIS			Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process	molecular_function	cytoplasm
YBR204C	YBR204C	LDH1	hom	Verified	0.251174916196604	0.400839438502841	no	1946	0.402164304643199	1321	NA	FT	LIPID METABOLISM			Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)	lipid homeostasis	hydrolase activity, acting on ester bonds|serine hydrolase activity|triglyceride lipase activity	lipid particle
YPR057W	YPR057W	BRR1	hom	Verified	0.250859026175	0.400961551988552	no	1947	0.334266649365368	1133	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed	spliceosomal complex assembly	RNA binding	small nuclear ribonucleoprotein complex
YOR369C	YOR369C	RPS12	hom	Verified	0.25023506163231	0.401202786149782	no	1948	0.388621942284976	1269	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YOL151W	YOL151W	GRE2	hom	Verified	0.249023245300184	0.401671400273698	no	1949	0.383440337860904	1285	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress	ergosterol metabolic process|filamentous growth	methylglyoxal reductase (NADPH-dependent) activity|3-methylbutanol:NAD(P) oxidoreductase activity	nucleus|cytoplasm
YGR061C	YGR061C	ADE6	hom	Verified	0.248108307606506	0.402025304004787	no	1950	0.381583768868308	1246	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway	'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process	phosphoribosylformylglycinamidine synthase activity	cytoplasm
YMR319C	YMR319C	FET4	hom	Verified	0.247915787130968	0.402099782392988	no	1951	0.429432230016621	1402	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Low-affinity Fe(II) transporter of the plasma membrane	intracellular copper ion transport|zinc ion transport|low-affinity iron ion transport|copper ion import	copper ion transmembrane transporter activity|iron ion transmembrane transporter activity	integral to membrane|plasma membrane|integral to plasma membrane
YIL166C_p	YIL166C	YIL166C	hom	Uncharacterized	0.247885237130516	0.402111601279871	no	1952	0.400567697520529	1304	NA					Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene	transport	transporter activity	integral to membrane|membrane
YBR114W	YBR114W	RAD16	hom	Verified	0.247359125700094	0.402315152184422	no	1953	0.411470695187274	1363	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|damaged DNA binding|DNA-dependent ATPase activity	nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YBR270C_p	YBR270C	BIT2	hom	Uncharacterized	0.246616331972345	0.402602581899624	no	1954	0.379866444753924	1276	NA					Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YNL049C	YNL049C	SFB2	hom	Verified	0.246588583469744	0.402613320416211	no	1955	0.394426731588521	1298	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p	cargo loading into COPII-coated vesicle	signal sequence binding	COPII vesicle coat
YCL033C	YCL033C	MXR2	hom	Verified	0.246522853242828	0.402638757942585	no	1956	0.400025475957966	1337	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan	cellular response to oxidative stress	peptide-methionine (R)-S-oxide reductase activity	mitochondrion
YOL060C	YOL060C	MAM3	hom	Verified	0.246380253641168	0.402693945250428	no	1957	0.393678483634806	1321	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS			Protein required for normal mitochondrial morphology, has similarity to hemolysins	cellular manganese ion homeostasis|mitochondrion organization	molecular_function	fungal-type vacuole membrane|integral to membrane
YPR118W	YPR118W	MRI1	hom	Verified	0.243341186141383	0.403870550569129	no	1958	0.409680260063508	1343	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway	L-methionine salvage from methylthioadenosine	S-methyl-5-thioribose-1-phosphate isomerase activity	nucleus|cytoplasm
YGL003C	YGL003C	CDH1	hom	Verified	0.243161337348245	0.403940208205755	no	1959	0.404043704223796	1340	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p	activation of mitotic anaphase-promoting complex activity|negative regulation of spindle pole body separation|positive regulation of mitotic metaphase/anaphase transition|Unknown|regulation of cell size	anaphase-promoting complex binding|cyclin binding|ubiquitin-protein ligase activator activity	nucleus|anaphase-promoting complex|cytoplasm
YHR133C	YHR133C	NSG1	hom	Verified	0.242507998611512	0.404193279905329	no	1960	0.397749891142776	1311	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; forms foci at the nuclear periphery upon DNA replication stress	sterol biosynthetic process	unfolded protein binding	integral to membrane|endoplasmic reticulum
YHR114W	YHR114W	BZZ1	hom	Verified	0.242357150130295	0.404251716983393	no	1961	0.384778801495395	1280	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins	response to salt stress|actin filament organization|endocytosis	molecular_function	mating projection tip|cytoplasm|actin cortical patch
YDR133C_d	YDR133C	YDR133C	hom	Dubious	0.241840236720797	0.404451979871038	no	1962	0.396470988001158	1302	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C	Unknown	Unknown	Unknown
YOR355W	YOR355W	GDS1	hom	Verified	0.241466054533514	0.404596961371387	no	1963	0.409709121249958	1358	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	aerobic respiration	molecular_function	mitochondrion|nucleus|cytoplasm
YDL214C	YDL214C	PRR2	hom	Verified	0.241437563327036	0.404608001177449	no	1964	0.405595777772803	1340	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance	negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation	protein kinase activity|receptor signaling protein serine/threonine kinase activity	nucleus
YNL001W	YNL001W	DOM34	hom	Verified	0.241093577736733	0.404741295107777	no	1965	0.417349889249437	1368	NA	FT	CELL CYCLE|TRANSLATION|CELL DIVISION			Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication	nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|nonfunctional rRNA decay	ribosome binding|endoribonuclease activity	cytoplasm
YLR206W	YLR206W	ENT2	hom	Verified	0.24108622535857	0.404744144264652	no	1966	0.375927912096594	1255	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus	actin filament organization|endocytosis|actin cortical patch assembly	clathrin binding	mating projection tip|actin cortical patch
YPR089W_p	YPR089W	YPR089W	hom	Uncharacterized	0.240795223612071	0.404856915862584	no	1967	0.407212464185925	1340	NA	FT		GOLGI APPARATUS		Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p	biological_process	molecular_function	cellular_component
YIL137C	YIL137C	TMA108	hom	Verified	0.240505403276155	0.404969237484071	no	1968	0.399998184986671	1307	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS			Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease	ribosome biogenesis	molecular_function	ribosome|cytoplasm
YIL017C	YIL017C	VID28	hom	Verified	0.238472628699472	0.405757271089541	no	1969	0.394769667728386	1317	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process|ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	nucleus|GID complex|cytoplasm
YCR099C_p	YCR099C	YCR099C	hom	Uncharacterized	0.237629776582221	0.406084126783158	no	1970	0.449578422243827	1496	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YKL106C-A_p	YKL106C-A	YKL106C-A	hom	Uncharacterized	0.236761778829112	0.406420802312218	no	1971	0.399843382009694	1317	NA					Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi	biological_process	molecular_function	cellular_component
YOL003C	YOL003C	PFA4	hom	Verified	0.236645094080164	0.406466066811848	no	1972	0.406909528664281	1366	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases	protein palmitoylation	palmitoyltransferase activity	integral to membrane|endoplasmic reticulum
YPL042C	YPL042C	SSN3	hom	Verified	0.236174272308038	0.406648721296866	no	1973	0.419265731081951	1410	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression	phosphorylation of RNA polymerase II C-terminal domain|negative regulation of transcription from RNA polymerase II promoter|negative regulation of filamentous growth|protein phosphorylation|protein destabilization|nuclear-transcribed mRNA catabolic process, non-stop decay|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II carboxy-terminal domain kinase activity|protein kinase activity|cyclin-dependent protein kinase activity	mediator complex
YOR029W_d	YOR029W	YOR029W	hom	Dubious	0.233780911754028	0.407577534600524	no	1974	0.370519753554927	1218	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL117W	YNL117W	MLS1	hom	Verified	0.233590639513663	0.407651397660292	no	1975	0.4150435218127	1375	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic	glyoxylate cycle	malate synthase activity	peroxisomal matrix|cytoplasm
YKL191W	YKL191W	DPH2	hom	Verified	0.232625416013766	0.408026144773766	no	1976	0.399764885345753	1303	NA					Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	molecular_function	cytoplasm
YJL022W_d	YJL022W	YJL022W	hom	Dubious	0.23196818554645	0.408281362061813	no	1977	0.41521987226886	1350	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130	Unknown	Unknown	Unknown
YPL158C	YPL158C	AIM44	hom	Verified	0.231438337582595	0.408487142210552	no	1978	0.446249637246646	1468	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cellular bud neck
YPR096C	YPR096C	YPR096C	hom	Verified	0.231381668614518	0.408509152563531	no	1979	0.399215377697468	1319	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments	biological_process	molecular_function	ribosome
YPL030W	YPL030W	TRM44	hom	Verified	0.230770324868233	0.408746618168334	no	1980	0.403830903099382	1341	NA	FT	RNA PROCESSING			tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene	tRNA methylation	tRNA (uracil) methyltransferase activity	cytoplasm
YHR063C	YHR063C	PAN5	hom	Verified	0.230736602384082	0.408759718043313	no	1981	0.423977373147743	1390	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE	pantothenate biosynthetic process	2-dehydropantoate 2-reductase activity	cytoplasm
YDL211C_p	YDL211C	YDL211C	hom	Uncharacterized	0.230505479438971	0.408849503070949	no	1982	0.407893588300252	1357	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	fungal-type vacuole
YDL063C	YDL063C	SYO1	hom	Verified	0.230501128377677	0.408851193386742	no	1983	0.414237134842499	1377	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	ribosomal large subunit biogenesis	molecular_function	nucleus|cytoplasm
YER010C	YER010C	YER010C	hom	Verified	0.230133851611628	0.408993880481346	no	1984	0.406283022085072	1333	NA					Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction	biological_process	molecular_function	cellular_component
YNL175C	YNL175C	NOP13	hom	Verified	0.23004692002282	0.409027655186275	no	1985	0.420866247765154	1370	NA	FT		NUCLEUS		Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress	biological_process	RNA binding	nucleolus|preribosome
YDL095W	YDL095W	PMT1	hom	Verified	0.229724058453225	0.409153099437666	no	1986	0.42324164158157	1419	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen	ER-associated misfolded protein catabolic process|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YBL036C	YBL036C	YBL036C	hom	Verified	0.229685581563362	0.409168049823568	no	1987	0.378565557563133	1238	NA					Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS	biological_process	pyridoxal phosphate binding	cellular_component
YMR008C	YMR008C	PLB1	hom	Verified	0.229610465466364	0.40919723693539	no	1988	0.402574761752489	1320	NA	FT	LIPID METABOLISM	PLASMA MEMBRANE		Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol	glycerophospholipid metabolic process	lysophospholipase activity	periplasmic space|plasma membrane
YPR152C	YPR152C	URN1	hom	Verified	0.229064202477154	0.409409508023146	no	1989	0.40766534038144	1369	NA	FT	RNA PROCESSING	NUCLEUS		Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase	biological_process	molecular_function	nucleus
YNL063W	YNL063W	MTQ1	hom	Verified	0.228656019611415	0.409568140214303	no	1990	0.419915803120897	1383	NA	FT	TRANSLATION	MITOCHONDRION		S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene	translational readthrough	S-adenosylmethionine-dependent methyltransferase activity	mitochondrion
YNR067C	YNR067C	DSE4	hom	Verified	0.227120026723361	0.410165205928622	no	1991	0.354758613869617	1170	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION			Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother	cytokinesis, completion of separation	glucan endo-1,3-beta-D-glucosidase activity	fungal-type cell wall|extracellular region|cell septum
YDR358W	YDR358W	GGA1	hom	Verified	0.226929796507293	0.410239166069575	no	1992	0.408450772594463	1335	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi	Golgi to vacuole transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to endosome transport	ubiquitin binding	trans-Golgi network
YHR149C	YHR149C	SKG6	hom	Verified	0.226504097288899	0.410404686429743	no	1993	0.414316608855288	1376	NA	FT		SITE OF POLARIZED GROWTH		Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p	biological_process	molecular_function	cell cortex|incipient cellular bud site|integral to membrane|cellular bud neck|cellular bud tip
YOR385W_p	YOR385W	YOR385W	hom	Uncharacterized	0.226454537509311	0.410423957299861	no	1994	0.412150505007373	1361	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene	biological_process	molecular_function	cytoplasm
YDR347W	YDR347W	MRP1	hom	Verified	0.225274261186675	0.410882960834164	no	1995	0.416142945825578	1373	NA	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YNL239W	YNL239W	LAP3	hom	Verified	0.224960775986514	0.411004894194027	no	1996	0.405451151947694	1330	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS	MITOCHONDRION		Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH	response to antibiotic|negative regulation of transcription from RNA polymerase II promoter|homocysteine catabolic process	double-stranded DNA binding|cysteine-type peptidase activity|mRNA binding|single-stranded DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	mitochondrion|cytoplasm
YDL215C	YDL215C	GDH2	hom	Verified	0.224741258464526	0.411090282958711	no	1997	0.408232744411722	1344	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels	nitrogen compound metabolic process	glutamate dehydrogenase (NAD+) activity	mitochondrion
YPL008W	YPL008W	CHL1	hom	Verified	0.224612593327882	0.411140333573791	no	1998	0.420613228853243	1374	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS		Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome	negative regulation of DNA recombination|chromosome segregation|donor selection|DNA replication initiation|mitotic sister chromatid cohesion	DNA helicase activity	nucleus
YHR095W_d	YHR095W	YHR095W	hom	Dubious	0.224021986280893	0.411370097696879	no	1999	0.412818821031832	1354	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL017C-A	YEL017C-A	PMP2	hom	Verified	0.223821429046945	0.411448127485699	no	2000	0.418809061279332	1394	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication	cation transport	molecular_function	membrane
YIL152W_p	YIL152W	YIL152W	hom	Uncharacterized	0.223514478101891	0.411567558119561	no	2001	0.400404832261865	1324	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR051W_d	YBR051W	YBR051W	hom	Dubious	0.221802048775795	0.412233992245799	no	2002	0.405960325323158	1356	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase	Unknown	Unknown	Unknown
YNR068C_p	YNR068C	YNR068C	hom	Uncharacterized	0.221655842000621	0.412290903976958	no	2003	0.405786029061308	1322	NA					Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form	biological_process	molecular_function	cellular_component
YOR021C	YOR021C	SFM1	hom	Verified	0.221331814025415	0.412417040086705	no	2004	0.400950267842917	1316	NA					SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism	peptidyl-arginine methylation	protein-arginine omega-N monomethyltransferase activity	cellular_component
YHR111W	YHR111W	UBA4	hom	Verified	0.220877189734635	0.412594029373033	no	2005	0.400099418986023	1344	NA	FT	RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS			Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p	cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|tRNA thio-modification|Unknown|invasive growth in response to glucose limitation	URM1 activating enzyme activity|sulfurtransferase activity|thiosulfate sulfurtransferase activity|protein adenylyltransferase activity	cytoplasm
YKL066W_d	YKL066W	YKL066W	hom	Dubious	0.219917150727365	0.412967839463947	no	2006	0.378087778547119	1262	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene YNK1	Unknown	Unknown	Unknown
YML124C	YML124C	TUB3	hom	Verified	0.219661100135083	0.413067551150314	no	2007	0.447548368056448	1473	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication	nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation	structural constituent of cytoskeleton	tubulin complex|cytoplasmic microtubule|kinetochore microtubule|nuclear microtubule|spindle pole body|polar microtubule
YMR052W	YMR052W	FAR3	hom	Verified	0.219561628457565	0.413106289104445	no	2008	0.423082942028508	1401	NA	FT	CELL CYCLE|SIGNALING	ENDOPLASMIC RETICULUM		Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	endoplasmic reticulum
YMR173W	YMR173W	DDR48	hom	Verified	0.218943698397627	0.413346952886894	no	2009	0.406064302610866	1361	NA	FT	RESPONSE TO DNA DAMAGE			DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress	DNA repair	ATPase activity|GTPase activity	cytoplasm
YER056C	YER056C	FCY2	hom	Verified	0.2181642284268	0.413650577674972	no	2010	0.385279723887943	1259	NA	FT		PLASMA MEMBRANE		Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress	cytosine transport|cytidine transport|purine nucleobase transport|transmembrane transport	nucleobase transmembrane transporter activity|cytidine transmembrane transporter activity	integral to membrane|plasma membrane
YHL003C	YHL003C	LAG1	hom	Verified	0.217312103294062	0.413982562702136	no	2011	0.40140527375971	1327	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress	replicative cell aging|ceramide biosynthetic process	sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YLR210W	YLR210W	CLB4	hom	Verified	0.216895340849792	0.414144954322604	no	2012	0.41125845723899	1326	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|CYTOSKELETON		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation	G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|spindle pole body|cytoplasm
YJR090C	YJR090C	GRR1	hom	Verified	0.215443616136215	0.41471073377805	no	2013	0.445388446986311	1465	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	UBIQUITIN LIGASE COMPLEX	F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|cell cycle arrest in response to pheromone|G1/S transition of mitotic cell cycle|response to DNA damage stimulus|protein ubiquitination	ubiquitin-protein ligase activity|protein binding, bridging	cellular bud neck contractile ring|SCF ubiquitin ligase complex|nucleus|cytoplasm
YKL134C	YKL134C	OCT1	hom	Verified	0.215236356273336	0.414791523454643	no	2014	0.406326756404135	1324	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis	cellular iron ion homeostasis|protein processing involved in protein targeting to mitochondrion	metalloendopeptidase activity	mitochondrion
YBR062C_p	YBR062C	YBR062C	hom	Uncharacterized	0.215231741804482	0.414793322210776	no	2015	0.411716310629732	1361	NA					Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.	biological_process	molecular_function	cellular_component
YPL234C	YPL234C	VMA11	hom	Verified	0.214676818772066	0.415009648573748	no	2016	0.425650189879124	1398	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane|fungal-type vacuole
YDL127W	YDL127W	PCL2	hom	Verified	0.212866030784487	0.415715729323354	no	2017	0.370749049419791	1233	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH		Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth	G1 phase of mitotic cell cycle|regulation of establishment or maintenance of cell polarity|regulation of cyclin-dependent protein kinase activity|septin ring organization	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|nucleus|cellular bud neck|cellular bud tip
YGR210C_p	YGR210C	YGR210C	hom	Uncharacterized	0.211232118956253	0.416353074424402	no	2018	0.407363804624527	1315	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YGL181W	YGL181W	GTS1	hom	Verified	0.211178445797126	0.416374014622748	no	2019	0.423035886044032	1395	NA	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	NUCLEUS|CYTOSKELETON		Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations	endocytosis|ultradian rhythm|regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylinositol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	ARF GTPase activator activity|repressing transcription factor binding|transcription factor binding transcription factor activity	nucleus|cytoplasm|actin cortical patch
YCR030C	YCR030C	SYP1	hom	Verified	0.211027838116795	0.416432774397028	no	2020	0.39992312713722	1282	NA	FT	CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization	septin cytoskeleton organization|actin cortical patch assembly	molecular_function	mating projection base|mating projection tip|cellular bud neck|cellular bud tip
YLR104W_p	YLR104W	LCL2	hom	Uncharacterized	0.209302510482203	0.417106046049657	no	2021	0.42233047705339	1371	NA	FT	PROTEOLYSIS			Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)	ER-associated protein catabolic process	molecular_function	cellular_component
YJR058C	YJR058C	APS2	hom	Verified	0.209104072486339	0.41718349779832	no	2022	0.3928226296622	1269	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YNL197C	YNL197C	WHI3	hom	Verified	0.206482367343449	0.418207068401285	no	2023	0.417268342405128	1380	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE			RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci;; Tpk1 (PKA) mediated phosphorylation of Whi3 affects G1/S transition by modulating Cln3 transcription; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; WHI3 has a paralog, WHI4, that arose from the whole genome duplication	pseudohyphal growth|invasive growth in response to glucose limitation|regulation of cell size|cytoplasmic sequestering of protein	RNA binding	cytoplasm
YBR107C	YBR107C	IML3	hom	Verified	0.205896616266985	0.418435834325316	no	2024	0.414320643213622	1384	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1	establishment of meiotic sister chromatid cohesion|ascospore formation|protein localization to chromosome, centromeric region|meiotic sister chromatid segregation|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome outer kinetochore
YEL049W	YEL049W	PAU2	hom	Verified	0.205819431771828	0.418465980899785	no	2025	0.397311285147151	1311	NA					Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YKL164C	YKL164C	PIR1	hom	Verified	0.205258800091827	0.418684965725443	no	2026	0.407847312500277	1343	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS			O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication	intracellular protein transport|fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall
YGR122C-A_d	YGR122C-A	YGR122C-A	hom	Dubious	0.204428462122076	0.419009345117228	no	2027	0.42126556905543	1384	NA					Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W	Unknown	Unknown	Unknown
YBR157C	YBR157C	ICS2	hom	Verified	0.204140420292017	0.419121884261463	no	2028	0.414213009710266	1371	NA					Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization	biological_process	molecular_function	cellular_component
YDR306C_p	YDR306C	YDR306C	hom	Uncharacterized	0.204060572626999	0.41915308224905	no	2029	0.427509449258272	1414	NA	FT	PROTEOLYSIS			F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YDR134C	YDR134C	YDR134C	hom	pseudogene	0.203877937609173	0.419224443103368	no	2030	0.415308902439014	1373	NA					Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication	biological_process	molecular_function	fungal-type cell wall
YML058W-A	YML058W-A	HUG1	hom	Verified	0.203249510173286	0.419470008408739	no	2031	0.416342431307495	1372	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress	cell cycle arrest|cell cycle checkpoint|response to DNA damage stimulus	molecular_function	cytoplasm
YOR042W	YOR042W	CUE5	hom	Verified	0.201141968004074	0.420293783404833	no	2032	0.418540723362992	1383	NA					Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	ubiquitin binding	cytoplasm
YPL034W_p	YPL034W	YPL034W	hom	Uncharacterized	0.200896428745586	0.420389780117915	no	2033	0.429802720524267	1402	NA					Putative protein of unknown function; YPL034W is not essential gene	biological_process	molecular_function	cellular_component
YLR218C	YLR218C	COA4	hom	Verified	0.199936061115768	0.420765293554286	no	2034	0.399392913451623	1297	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION		Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors	mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain complex assembly	molecular_function	nucleus|mitochondrial intermembrane space|cytoplasm
YLR131C	YLR131C	ACE2	hom	Verified	0.199908493021056	0.420776074023854	no	2035	0.453937670552738	1869	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION	NUCLEUS		Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication	Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YBR024W	YBR024W	SCO2	hom	Verified	0.198093824784439	0.421485828104426	no	2036	0.418929756528409	1361	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication	copper ion transport	thioredoxin peroxidase activity	mitochondrial envelope|mitochondrion
YKL202W_d	YKL202W	YKL202W	hom	Dubious	0.196192453585136	0.422229767223335	no	2037	0.396813303692902	1326	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR040W	YJR040W	GEF1	hom	Verified	0.19601593583007	0.422298846480816	no	2038	0.417751794275258	1376	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE		Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism	cellular copper ion homeostasis|cellular iron ion homeostasis	voltage-gated chloride channel activity	endosome|integral to membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|fungal-type vacuole|Golgi medial cisterna
YOL100W	YOL100W	PKH2	hom	Verified	0.195302629958261	0.422578019153826	no	2039	0.409422056816592	1342	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p	regulation of nuclear-transcribed mRNA poly(A) tail shortening|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly	protein kinase activity	cell cortex|eisosome|nucleus
YDL049C	YDL049C	KNH1	hom	Verified	0.195022248776563	0.42268776501231	no	2040	0.413446061975792	1357	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance	(1->6)-beta-D-glucan biosynthetic process	molecular_function	fungal-type cell wall|extracellular region
YER019C-A	YER019C-A	SBH2	hom	Verified	0.194762284198278	0.422789524834342	no	2041	0.415687816390623	1366	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p	SRP-dependent cotranslational protein targeting to membrane	ARF guanyl-nucleotide exchange factor activity	Ssh1 translocon complex
YHR001W	YHR001W	OSH7	hom	Verified	0.194752964540449	0.422793172991366	no	2042	0.415526748567806	1403	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	maintenance of cell polarity|endocytosis|exocytosis|sterol transport|sterol metabolic process|late endosome to vacuole transport	lipid binding|oxysterol binding	integral to membrane|cortical endoplasmic reticulum|cytoplasm
YLR384C	YLR384C	IKI3	hom	Verified	0.194495282515022	0.422894044604852	no	2043	0.404902567737672	1347	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YPL101W	YPL101W	ELP4	hom	Verified	0.194414441738495	0.422925691391573	no	2044	0.438555517046069	1452	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex|cytoplasm
YKL097C_d	YKL097C	YKL097C	hom	Dubious	0.194247285779247	0.422991129611329	no	2045	0.418951734086637	1385	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species	Unknown	Unknown	Unknown
YCR095C_p	YCR095C	OCA4	hom	Uncharacterized	0.193831504890557	0.423153908737546	no	2046	0.410266951335341	1346	NA					Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts	biological_process	molecular_function	cytoplasm
YLR264C-A_p	YLR264C-A	YLR264C-A	hom	Uncharacterized	0.193661202745868	0.423220586188027	no	2047	0.420184328801226	1382	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YIL173W	YIL173W	VTH1	hom	Verified	0.193458655817497	0.423299891122079	no	2048	0.417048164145461	1372	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting	Golgi to vacuole transport	signal sequence binding	endosome|integral to membrane
YPL026C	YPL026C	SKS1	hom	Verified	0.189855992616556	0.42471098898965	no	2049	0.378820564381773	1287	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION	NUCLEUS		Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway	glucose transport|protein phosphorylation|response to glucose stimulus|positive regulation of transcription from RNA polymerase II promoter	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YIL038C	YIL038C	NOT3	hom	Verified	0.189099365628453	0.425007469335826	no	2050	0.404155444711623	1325	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation	regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of transcription elongation from RNA polymerase II promoter|protein ubiquitination	ubiquitin-protein ligase activity	CCR4-NOT core complex|cytoplasm
YCR061W_p	YCR061W	YCR061W	hom	Uncharacterized	0.188969919035997	0.425058196563464	no	2051	0.427434040796335	1438	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation	regulation of cell size	molecular_function	integral to membrane|cytoplasm
YGR292W	YGR292W	MAL12	hom	Verified	0.188584164068801	0.425209372672614	no	2052	0.413619006520128	1361	NA	FT	CARBOHYDRATE METABOLISM			Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose	sucrose catabolic process|maltose catabolic process	sucrose alpha-glucosidase activity|maltose alpha-glucosidase activity	plasma membrane
YNL074C	YNL074C	MLF3	hom	Verified	0.1881426901389	0.425382398355247	no	2053	0.427244331165291	1402	NA					Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide	response to drug	molecular_function	cytoplasm
YBR276C	YBR276C	PPS1	hom	Verified	0.187675762880378	0.425565415530362	no	2054	0.388455348975484	1284	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle	inactivation of MAPK activity|protein dephosphorylation|regulation of S phase of mitotic cell cycle	protein tyrosine/serine/threonine pho