strainid	orf	gene	zyg	qualifier	SGTC_1290|0986-0249.score	SGTC_1290|0986-0249.expt.zyg.pval	SGTC_1290|0986-0249.expt.zyg.significant	SGTC_1290|0986-0249.expt.zyg.rank	strain.pval	strain.rank	clearance	Fclass	Fterms.BP	Fterms.CC	Fterms.complex	description	GO_process	GO_function	GO_component
YDL119C_p	YDL119C	YDL119C	hom	Uncharacterized	9.52864246974261	7.96766709909266e-22	yes	1	1.28456808360135e-19	6	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria	transport	transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDR076W	YDR076W	RAD55	hom	Verified	9.33399102831061	5.09788423693086e-21	yes	2	9.0831863373096e-20	12	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p	DNA recombinase assembly|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|protein heterodimerization activity	nucleus|Rhp55-Rhp57 complex
YDR004W	YDR004W	RAD57	hom	Verified	7.85717713748688	1.96443527315892e-15	yes	3	1.134804262298e-13	17	NA	FF|FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p	DNA recombinase assembly|telomere maintenance via recombination|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|protein heterodimerization activity	nucleus|Rhp55-Rhp57 complex
YDR458C	YDR458C	HEH2	hom	Verified	7.3406840850448	1.06252434193257e-13	yes	4	2.69343853809729e-13	1	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle	biological_process	molecular_function	nuclear envelope
YDL118W_d	YDL118W	YDL118W	hom	Dubious	6.44600109455506	5.74199162351901e-11	yes	5	1.24599831192137e-08	26	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein	biological_process	molecular_function	cellular_component
YMR166C_p	YMR166C	YMR166C	hom	Uncharacterized	5.742471480819	4.66522985307735e-09	yes	6	1.6057487419787e-08	19	NA	FT		MITOCHONDRION		Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene	transport	transporter activity	integral to membrane|mitochondrial inner membrane
YGL200C	YGL200C	EMP24	hom	Verified	5.28163807624824	6.40169674402196e-08	yes	7	5.79345486036577e-08	7	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles	protein retention in ER lumen|vesicle organization|ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum|ER to Golgi transport vesicle
YMR289W	YMR289W	ABZ2	hom	Verified	5.27506707698224	6.63537693844368e-08	yes	8	1.86067543137371e-07	9	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis	folic acid biosynthetic process	4-amino-4-deoxychorismate lyase activity	cytoplasm
YDL223C	YDL223C	HBT1	hom	Verified	4.74454463469942	1.04487949165273e-06	yes	9	8.45906190148242e-06	19	NA					Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis	cell morphogenesis involved in conjugation with cellular fusion	molecular_function	plasma membrane|mating projection
YER129W	YER129W	SAK1	hom	Verified	4.7265227445207	1.14198609956952e-06	yes	10	3.91299652506069e-06	13	NA	FT	CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION			Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome	protein phosphorylation|glucose metabolic process|DNA-dependent DNA replication	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YOR133W	YOR133W	EFT1	hom	Verified	4.69623183403982	1.32502376232114e-06	yes	11	2.147897767424e-06	16	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication	translational elongation	translation elongation factor activity	ribosome
YBR035C	YBR035C	PDX3	hom	Verified	4.68554169095147	1.39610225793695e-06	yes	12	5.0507917500451e-07	18	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism	fatty acid metabolic process	pyridoxamine-phosphate oxidase activity	cellular_component
YMR001C-A_p	YMR001C-A	YMR001C-A	hom	Uncharacterized	4.66954382485367	1.50934649595571e-06	yes	13	4.96458151577844e-07	27	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHL039W	YHL039W	EFM1	hom	Verified	4.59601589732785	2.1532292849687e-06	yes	14	2.81396710520078e-06	27	NA					Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	cytoplasm
YDR150W	YDR150W	NUM1	hom	Verified	4.43431137789661	4.61835237031311e-06	yes	15	0.000140520402805903	24	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex	mitochondrion inheritance|nuclear migration along microtubule|mitochondrial fission|microtubule cytoskeleton organization	tubulin binding	cell cortex|mitochondrion|cellular bud tip
YDR158W	YDR158W	HOM2	hom	Verified	4.32394104921732	7.66331338216488e-06	yes	16	2.52226331569153e-05	30	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	methionine biosynthetic process|threonine biosynthetic process|homoserine biosynthetic process	aspartate-semialdehyde dehydrogenase activity	nucleus|plasma membrane|cytoplasm
YIL034C	YIL034C	CAP2	hom	Verified	4.28304089199318	9.21781368588971e-06	yes	17	9.95261193209923e-06	24	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress	barbed-end actin filament capping|filamentous growth	actin filament binding	actin filament|F-actin capping protein complex|mating projection tip|actin cortical patch
YDL059C	YDL059C	RAD59	hom	Verified	4.23100899196317	1.16322685233525e-05	yes	18	4.1014287756439e-05	24	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p	DNA strand renaturation|telomere maintenance via recombination|double-strand break repair via break-induced replication|double-strand break repair via single-strand annealing	protein binding	nucleus
YGL175C	YGL175C	SAE2	hom	Verified	4.22838344519714	1.17688199084769e-05	yes	19	6.27989609108837e-06	25	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents	DNA double-strand break processing|DNA catabolic process, endonucleolytic|meiotic DNA double-strand break formation|meiotic DNA double-strand break processing|gene conversion at mating-type locus, DNA double-strand break processing	double-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity	nucleus|cytoplasm
YBR099C_d	YBR099C	YBR099C	hom	Dubious	4.17129063778389	1.51439629243355e-05	yes	20	3.45287672261475e-06	19	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4	Unknown	Unknown	Unknown
YDR217C	YDR217C	RAD9	hom	Verified	3.91869004047991	4.45157591267701e-05	yes	21	3.12215043739605e-05	12	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate	DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of cell cycle|intra-S DNA damage checkpoint|nucleotide-excision repair|DNA damage checkpoint|positive regulation of transcription from RNA polymerase II promoter	double-stranded DNA binding|histone binding	chromatin|nucleus
YOL128C	YOL128C	YGK3	hom	Verified	3.89900795153579	4.8293801574795e-05	yes	22	0.000122443882531978	17	NA	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION			Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation	proteolysis|protein phosphorylation|response to stress	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YKL139W	YKL139W	CTK1	hom	Verified	3.87985903416483	5.22585099903356e-05	yes	23	0.000200925337906151	43	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION	NUCLEUS		Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13	mRNA 3'-end processing|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of translational fidelity|positive regulation of transcription from RNA polymerase I promoter|peptidyl-serine phosphorylation|positive regulation of DNA-dependent transcription, elongation|protein phosphorylation	protein kinase activity|cyclin-dependent protein kinase activity	nucleoplasm|nucleolus|nucleus|polysome|carboxy-terminal domain protein kinase complex
YGL205W	YGL205W	POX1	hom	Verified	3.8740203666685	5.35272300396878e-05	yes	24	4.53442273750515e-06	11	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix	fatty acid beta-oxidation using acyl-CoA oxidase|fatty acid beta-oxidation	acyl-CoA oxidase activity	peroxisomal matrix
YDR386W	YDR386W	MUS81	hom	Verified	3.815545794171	6.79411258990643e-05	yes	25	0.00027321371366321	32	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	crossover junction endodeoxyribonuclease activity|endonuclease activity	Holliday junction resolvase complex|nucleus
YLR083C	YLR083C	EMP70	hom	Verified	3.78295726133645	7.74880164533138e-05	yes	26	0.000284006017394445	14	NA	FT	VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments	cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|endosomal transport|invasive growth in response to glucose limitation	molecular_function	endosome|fungal-type vacuole membrane|integral to membrane
YBL051C	YBL051C	PIN4	hom	Verified	3.77756543216612	7.918445250599e-05	yes	27	0.000286260448785816	50	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE			Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage	G2/M transition of mitotic cell cycle|DNA damage checkpoint	molecular_function	cytoplasm
YGL163C	YGL163C	RAD54	hom	Verified	3.71257177467429	0.000102581926076217	yes	28	0.000753922609528362	61	NA	FF|FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS		DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress	positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|DNA translocase activity	nucleus
YNL009W	YNL009W	IDP3	hom	Verified	3.70431634236935	0.00010598080529503	yes	29	0.000103462845649088	10	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication	NADPH regeneration|fatty acid beta-oxidation|isocitrate metabolic process	isocitrate dehydrogenase (NADP+) activity	mitochondrion|peroxisome|cytoplasm
YLR025W	YLR025W	SNF7	hom	Verified	3.58818862655687	0.000166491678097241	yes	30	0.00513344744210094	159	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes	cellular response to anoxia|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	protein binding	ESCRT III complex|cytoplasm
YLR420W	YLR420W	URA4	hom	Verified	3.57057378832047	0.000178100045470373	yes	31	0.000283385202187039	35	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate	'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine nucleotide biosynthetic process	dihydroorotase activity	nucleus|cytoplasm
YGL249W	YGL249W	ZIP2	hom	Verified	3.52341201652358	0.000213014258996904	yes	32	3.84213978862075e-05	12	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	synaptonemal complex assembly|synapsis|reciprocal meiotic recombination	molecular_function	synaptonemal complex
YDL179W	YDL179W	PCL9	hom	Verified	3.51905009870438	0.000216547457419376	yes	33	0.000248300210112563	15	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p	regulation of establishment or maintenance of cell polarity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|cellular bud neck
YNL173C	YNL173C	MDG1	hom	Verified	3.47840435247131	0.000252204206514276	yes	34	0.000459790778208245	30	NA	FT	SIGNALING	PLASMA MEMBRANE		Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations	pheromone-dependent signal transduction involved in conjugation with cellular fusion	molecular_function	membrane raft|plasma membrane
YPR174C	YPR174C	YPR174C	hom	Verified	3.46633583757149	0.000263801906446825	yes	35	0.000177901826449603	19	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication	biological_process	molecular_function	nuclear envelope|spindle pole body
YJR135C	YJR135C	MCM22	hom	Verified	3.44797882199691	0.000282399160398326	yes	36	8.23302155715789e-05	13	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YPL157W	YPL157W	TGS1	hom	Verified	3.43306521281701	0.000298399268236049	yes	37	0.000522484889105253	46	NA	FT	CELL CYCLE|RNA PROCESSING	NUCLEUS		Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs	meiosis|RNA methylation|nucleologenesis|7-methylguanosine cap hypermethylation|regulation of telomere maintenance via telomerase	RNA methyltransferase activity	nucleolus
YDR270W	YDR270W	CCC2	hom	Verified	3.37740113337327	0.00036587126488132	yes	38	0.0010983283556775	72	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism	cellular iron ion homeostasis|copper ion export|transmembrane transport	copper ion binding|cation-transporting ATPase activity	integral to membrane|trans-Golgi network transport vesicle membrane
YEL006W	YEL006W	YEA6	hom	Verified	3.2948047138732	0.000492450495273089	yes	39	0.00055830716702855	22	NA	FT		MITOCHONDRION		Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog	transport|NAD transmembrane transport	transporter activity|NAD transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YPL035C_d	YPL035C	YPL035C	hom	Dubious	3.25608023220099	0.0005648091300294	yes	40	0.000605442460365102	29	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene	Unknown	Unknown	Unknown
YMR090W_p	YMR090W	YMR090W	hom	Uncharacterized	3.17498775881721	0.000749214111777357	yes	41	0.00120904733639807	39	NA					Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability	biological_process	molecular_function	cytoplasm
YLR133W	YLR133W	CKI1	hom	Verified	3.15793008405634	0.000794468306124101	yes	42	0.00347439137210984	55	NA	FT	LIPID METABOLISM			Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolamine kinase activity|choline kinase activity	cytoplasm
YBR158W	YBR158W	AMN1	hom	Verified	3.13055556457779	0.00087237994466355	yes	43	0.000959161079487389	25	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS		Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)	mitotic cell cycle checkpoint|negative regulation of exit from mitosis	protein binding	nucleus|cellular bud|cytoplasm
YGL179C	YGL179C	TOS3	hom	Verified	3.09009988714787	0.00100044595800478	no	44	0.000300385979463079	26	NA	FT	CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION			Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome	protein phosphorylation|glucose metabolic process	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YJL186W	YJL186W	MNN5	hom	Verified	3.06457179786464	0.00108990922887483	no	45	0.000334722252465756	32	NA	FT	CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment	protein glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YFL013W-A_d	YFL013W-A	YFL013W-A	hom	Dubious	3.04707612210618	0.00115539591128624	no	46	0.0019514342101552	64	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching	Unknown	Unknown	Unknown
YOR191W	YOR191W	ULS1	hom	Verified	3.04052284782979	0.00118083886142791	no	47	0.000982670633616126	64	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION		Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress	chromatin assembly or disassembly|mating type switching	SUMO binding|DNA-dependent ATPase activity	mitochondrion|nucleolus|nucleus
YOR072W_d	YOR072W	YOR072W	hom	Dubious	3.03484800259743	0.001203284688167	no	48	0.0105689649254119	145	NA	FF				Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive	Unknown	Unknown	Unknown
YIR028W	YIR028W	DAL4	hom	Verified	3.02209678065092	0.00125515137427778	no	49	0.000877640839661203	40	NA					Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process|allantoin transport	allantoin uptake transmembrane transporter activity	integral to membrane|membrane
YGL250W	YGL250W	RMR1	hom	Verified	3.00964617736651	0.00130776092749705	no	50	0.000856654964111437	19	NA	FT	CELL CYCLE	NUCLEUS		Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus	meiotic gene conversion|reciprocal meiotic recombination	molecular_function	nucleus|cytoplasm
YPR127W	YPR127W	YPR127W	hom	Verified	2.98914727558093	0.00139878624622266	no	51	0.00105857115291038	62	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YBR278W	YBR278W	DPB3	hom	Verified	2.98525371740061	0.00141671600414693	no	52	0.00175583310045666	44	NA	FT	RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication	DNA-dependent DNA replication|chromatin silencing at telomere	double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity	epsilon DNA polymerase complex
YNL273W	YNL273W	TOF1	hom	Verified	2.98253873480844	0.00142934236008946	no	53	0.000834706489437893	25	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase	DNA repair|DNA replication checkpoint|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|DNA replication|mitotic sister chromatid cohesion	molecular_function	nuclear chromosome|replication fork protection complex|nuclear replication fork
YGL041C_d	YGL041C	YGL041C	hom	Dubious	2.97563876833404	0.00146189518089031	no	54	0.00242812634314792	49	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL017C	YPL017C	IRC15	hom	Verified	2.8911230739159	0.00191933879197532	no	55	0.00510616012521445	85	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci	microtubule nucleation|mitotic recombination|microtubule anchoring|meiotic sister chromatid segregation|attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|positive regulation of mitotic cell cycle	microtubule binding|S-adenosylmethionine-dependent methyltransferase activity	microtubule|cytoplasm
YJL098W	YJL098W	SAP185	hom	Verified	2.88622868891856	0.00194944370950933	no	56	0.00144781893743979	35	NA	FT	CELL CYCLE|RNA PROCESSING	MITOCHONDRION		Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication	tRNA wobble uridine modification|G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	mitochondrion|cytoplasm
YCR007C_p	YCR007C	YCR007C	hom	Uncharacterized	2.84567959205642	0.00221583807844562	no	57	0.00389735169849748	52	NA					Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene	biological_process	molecular_function	cellular_component
YGR286C	YGR286C	BIO2	hom	Verified	2.83481849656558	0.00229258638694923	no	58	0.00178034196031869	59	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant	biotin biosynthetic process	biotin synthase activity	mitochondrion
YPR098C	YPR098C	YPR098C	hom	Verified	2.83038481737567	0.00232460239986647	no	59	0.00458683502670006	53	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YGL254W	YGL254W	FZF1	hom	Verified	2.82285586212865	0.002379898272451	no	60	0.0029401904351982	26	NA	FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS		Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress	positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDR369C	YDR369C	XRS2	hom	Verified	2.8147088539461	0.00244107211744024	no	61	0.00394442451338899	104	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling	double-strand break repair via nonhomologous end joining|meiotic DNA double-strand break formation|base-excision repair|telomere maintenance|sporulation resulting in formation of a cellular spore|double-strand break repair via break-induced replication	single-stranded telomeric DNA binding|protein binding, bridging|DNA binding|double-stranded telomeric DNA binding|telomeric DNA binding|G-quadruplex DNA binding	nucleus|Mre11 complex
YGL118C_d	YGL118C	YGL118C	hom	Dubious	2.79477524495535	0.00259679042347094	no	62	0.00239010536748719	52	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR170C	YBR170C	NPL4	hom	Verified	2.77330502640668	0.00277450405738412	no	63	0.00299096915944436	42	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)	retrograde protein transport, ER to cytosol|proteasomal ubiquitin-dependent protein catabolic process|mitochondria-associated protein catabolic process|mitotic spindle disassembly|ER-associated protein catabolic process|ER-associated misfolded protein catabolic process|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process	molecular_function	Doa10p ubiquitin ligase complex|integral to membrane|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|Cdc48p-Npl4p-Vms1p AAA ATPase complex|nuclear outer membrane-endoplasmic reticulum membrane network
YJL092W	YJL092W	SRS2	hom	Verified	2.72308119880816	0.00323380797298718	no	64	0.00330422184652801	81	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability	DNA repair|double-strand break repair via nonhomologous end joining|DNA duplex unwinding	DNA helicase activity	nucleus
YDL161W	YDL161W	ENT1	hom	Verified	2.71266207335984	0.00333725665070731	no	65	0.00121496091315174	28	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress	actin filament organization|endocytosis|actin cortical patch assembly	clathrin binding	mating projection tip|actin cortical patch
YLR448W	YLR448W	RPL6B	hom	Verified	2.69862877540541	0.00348128972528761	no	66	0.00523724172673521	80	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YHR034C	YHR034C	PIH1	hom	Verified	2.67228087868848	0.00376687796291662	no	67	0.00858366784604831	93	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II	protein folding|rRNA processing|regulation of cell size|box C/D snoRNP assembly	molecular_function	R2TP complex|nucleus|small nucleolar ribonucleoprotein complex|cytoplasm
YNL099C	YNL099C	OCA1	hom	Verified	2.66660970712752	0.00383102972700122	no	68	0.00555076110106711	140	NA	FF|FT	RESPONSE TO OXIDATIVE STRESS			Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA	cellular response to oxidative stress	protein tyrosine phosphatase activity	cytoplasm
YLR170C	YLR170C	APS1	hom	Verified	2.66195781622252	0.0038843806909691	no	69	0.00557260262321978	91	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YDR272W	YDR272W	GLO2	hom	Verified	2.65514378549081	0.0039637305074162	no	70	0.00308817900242105	60	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM			Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate	cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate	hydroxyacylglutathione hydrolase activity	cytoplasm
YPR118W	YPR118W	MRI1	hom	Verified	2.63306792627126	0.00423087112534453	no	71	0.00603663376489809	43	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway	L-methionine salvage from methylthioadenosine	S-methyl-5-thioribose-1-phosphate isomerase activity	nucleus|cytoplasm
YBR108W	YBR108W	AIM3	hom	Verified	2.62068146395738	0.00438771066784754	no	72	0.00293528060466504	52	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss	actin cortical patch assembly	molecular_function	membrane raft|actin cortical patch
YMR042W	YMR042W	ARG80	hom	Verified	2.60446559388632	0.00460088296508142	no	73	0.00385975817699258	30	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding	nucleus
YER095W	YER095W	RAD51	hom	Verified	2.60072704138894	0.00465132197164528	no	74	0.0104653918741463	148	NA	FF|FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein	strand invasion|telomere maintenance via recombination|heteroduplex formation|meiotic joint molecule formation|reciprocal meiotic recombination|double-strand break repair via single-strand annealing	recombinase activity|single-stranded DNA binding|DNA-dependent ATPase activity	condensed nuclear chromosome|nuclear chromosome
YER073W	YER073W	ALD5	hom	Verified	2.59631153363964	0.00471152923554856	no	75	0.00586417310862501	61	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed	acetate biosynthetic process	aldehyde dehydrogenase [NAD(P)+] activity	mitochondrion
YKL137W	YKL137W	CMC1	hom	Verified	2.58814118792893	0.00482477100936602	no	76	0.00429163716306836	58	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif	mitochondrial respiratory chain complex IV assembly	copper ion binding	extrinsic to mitochondrial inner membrane|mitochondrial intermembrane space
YBR021W	YBR021W	FUR4	hom	Verified	2.58745244848275	0.00483442699919466	no	77	0.0195571065667892	197	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation	uracil transport|transmembrane transport	uracil:cation symporter activity	integral to membrane|membrane raft|plasma membrane
YPL130W	YPL130W	SPO19	hom	Verified	2.57045055338976	0.00507831624170767	no	78	0.0022666243849933	40	NA	FT	CELL CYCLE|MEMBRANE ORGANIZATION			Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation	meiosis|spore membrane bending pathway	molecular_function	fungal-type cell wall|prospore membrane
YMR004W	YMR004W	MVP1	hom	Verified	2.56388777330434	0.00517535032861474	no	79	0.00754460590065857	61	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	NUCLEUS		Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress	protein targeting to vacuole	phosphatidylinositol-3-phosphate binding	nucleus|cytoplasm
YEL023C_p	YEL023C	YEL023C	hom	Uncharacterized	2.52040297667596	0.00586102746343346	no	80	0.00577805702957275	51	NA					Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene	biological_process	molecular_function	cellular_component
YMR206W_p	YMR206W	YMR206W	hom	Uncharacterized	2.51875023515717	0.0058886082572312	no	81	0.00365234391619868	67	NA					Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YBR271W	YBR271W	EFM2	hom	Verified	2.51746436276652	0.00591014633268985	no	82	0.00876091936483006	64	NA					S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis	peptidyl-lysine methylation	S-adenosylmethionine-dependent methyltransferase activity|protein-lysine N-methyltransferase activity	cytoplasm
YJL147C_p	YJL147C	YJL147C	hom	Uncharacterized	2.49699083153367	0.0062626097538205	no	83	0.00370288878959954	55	NA	FT		MITOCHONDRION		Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene	biological_process	molecular_function	mitochondrion
YOR366W_d	YOR366W	YOR366W	hom	Dubious	2.48311986941317	0.00651186269531932	no	84	0.00772519747869158	86	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C	Unknown	Unknown	Unknown
YDR375C	YDR375C	BCS1	hom	Verified	2.47739576573488	0.00661725296697534	no	85	0.00963023098740271	76	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases	protein insertion into mitochondrial membrane from inner side|chaperone-mediated protein complex assembly|mitochondrial respiratory chain complex III assembly	protein transmembrane transporter activity|ATPase activity	mitochondrion|mitochondrial inner membrane
YDL198C	YDL198C	GGC1	hom	Verified	2.46290603031638	0.00689080152282819	no	86	0.00803509129288204	92	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family	cellular iron ion homeostasis|mitochondrial genome maintenance|transmembrane transport|guanine nucleotide transport	guanine nucleotide transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YBR284W_p	YBR284W	YBR284W	hom	Uncharacterized	2.45578528783025	0.00702885607019361	no	87	0.00750762595269911	115	NA	FT	NUCLEOTIDE METABOLISM			Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication	biological_process	AMP deaminase activity|molecular_function	cellular_component
YHR037W	YHR037W	PUT2	hom	Verified	2.44292530950263	0.00728437603293592	no	88	0.0111763275858319	106	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism	glutamate biosynthetic process|proline catabolic process to glutamate	1-pyrroline-5-carboxylate dehydrogenase activity	mitochondrion|mitochondrial matrix
YMR044W	YMR044W	IOC4	hom	Verified	2.44096385224174	0.00732406044910452	no	89	0.0126624178863665	120	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing	chromatin remodeling	nucleosome binding|ATPase activity|DNA binding	ISW1 complex
YGR157W	YGR157W	CHO2	hom	Verified	2.43452697518012	0.00745563418474275	no	90	0.00965553382686583	73	NA	FT	LIPID METABOLISM			Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis	phosphatidylcholine biosynthetic process	phosphatidylethanolamine N-methyltransferase activity	integral to membrane|endoplasmic reticulum
YDL083C	YDL083C	RPS16B	hom	Verified	2.43421782012188	0.00746200558941408	no	91	0.0141079674556081	61	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YBR098W	YBR098W	MMS4	hom	Verified	2.43269808552944	0.00749339573863755	no	92	0.00551289180486581	66	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	transcription coactivator activity|endonuclease activity|crossover junction endodeoxyribonuclease activity	Holliday junction resolvase complex|nucleus
YKL221W	YKL221W	MCH2	hom	Verified	2.42655547076981	0.00762145995414048	no	93	0.0103799637454896	48	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|membrane
YPR001W	YPR001W	CIT3	hom	Verified	2.40931106257124	0.00799133457305549	no	94	0.0122469117921977	112	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate	propionate catabolic process, 2-methylcitrate cycle|propionate metabolic process|tricarboxylic acid cycle	2-methylcitrate synthase activity|citrate (Si)-synthase activity	mitochondrion
YEL065W	YEL065W	SIT1	hom	Verified	2.40774413177642	0.00802571314432381	no	95	0.00334685528041121	54	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p	cellular iron ion homeostasis|siderophore transport|transmembrane transport	siderophore uptake transmembrane transporter activity	endosome|integral to membrane|cytoplasmic membrane-bounded vesicle
YHR137W	YHR137W	ARO9	hom	Verified	2.4073040409301	0.00803539212473998	no	96	0.00575304498625436	80	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism	aromatic amino acid family metabolic process	aromatic-amino-acid:2-oxoglutarate aminotransferase activity	nucleus|cytoplasm
YLR124W_d	YLR124W	YLR124W	hom	Dubious	2.39176320019828	0.00838382836883293	no	97	0.00918015243326535	77	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR012W_d	YPR012W	YPR012W	hom	Dubious	2.38707488625668	0.00849151574817135	no	98	0.00683340009524953	93	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene	Unknown	Unknown	Unknown
YER055C	YER055C	HIS1	hom	Verified	2.38473982078854	0.00854560204122223	no	99	0.00905669156044807	70	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control	histidine biosynthetic process	ATP phosphoribosyltransferase activity	cellular_component
YHR046C	YHR046C	INM1	hom	Verified	2.38451753158325	0.00855076656953879	no	100	0.0119236413235691	102	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	NUCLEUS		Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate	inositol phosphate dephosphorylation	inositol monophosphate 1-phosphatase activity	nucleus|cytoplasm
YFL010C	YFL010C	WWM1	hom	Verified	2.38175023999655	0.00861528969897241	no	101	0.00809131135948227	73	NA	FT		NUCLEUS|MITOCHONDRION		WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1	biological_process	molecular_function	mitochondrion|nucleus|cytoplasm
YGL236C	YGL236C	MTO1	hom	Verified	2.36832282405169	0.00893446833287633	no	102	0.0132000047533228	75	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants	mitochondrial tRNA wobble uridine modification	molecular_function	mitochondrion
YPL158C	YPL158C	AIM44	hom	Verified	2.36666288725079	0.00897463693278396	no	103	0.0181331694209109	108	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cellular bud neck
YLR453C	YLR453C	RIF2	hom	Verified	2.36548574336066	0.00900321827831597	no	104	0.00688954199956149	114	NA	FT		NUCLEUS|CHROMOSOME		Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation	telomere capping|telomere maintenance via telomerase	telomeric DNA binding	nuclear telomere cap complex
YPR031W	YPR031W	NTO1	hom	Verified	2.36079407229806	0.00911792683945503	no	105	0.014667821699891	95	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3	histone acetylation	histone acetyltransferase activity|methylated histone residue binding	nucleus|NuA3 histone acetyltransferase complex|cytoplasm
YMR256C	YMR256C	COX7	hom	Verified	2.35836516190719	0.00917781343154438	no	106	0.0183101760028565	135	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YDR025W	YDR025W	RPS11A	hom	Verified	2.3446610110281	0.00952219286818707	no	107	0.0111281111308842	103	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YML082W_p	YML082W	YML082W	hom	Uncharacterized	2.29911283589274	0.0107492664063165	no	108	0.0192588464509872	102	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene	sulfur compound metabolic process	carbon-sulfur lyase activity	nucleus|cytoplasm
YOL155C	YOL155C	HPF1	hom	Verified	2.27538801559291	0.0114413318318185	no	109	0.0142989452519019	133	NA	FT	CELL WALL ORG/BIOGENESIS			Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines	fungal-type cell wall organization	glucosidase activity	fungal-type cell wall|extracellular region
YMR307W	YMR307W	GAS1	hom	Verified	2.26033766830154	0.0119001509161153	no	110	0.0139620802343359	173	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|GENE SILENCING	NUCLEUS|MITOCHONDRION|PLASMA MEMBRANE		Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery	fungal-type cell wall organization|chromatin silencing|filamentous growth	1,3-beta-glucanosyltransferase activity	mitochondrion|membrane raft|primary cell septum|nuclear periphery|integral to membrane|fungal-type cell wall|plasma membrane|cellular bud scar|ER to Golgi transport vesicle
YCL005W	YCL005W	LDB16	hom	Verified	2.24237840973589	0.0124684629888454	no	111	0.0205792512904637	167	NA	FT		MITOCHONDRION		Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria	biological_process	molecular_function	mitochondrion|lipid particle
YOR199W_d	YOR199W	YOR199W	hom	Dubious	2.24101287612628	0.0125126204830048	no	112	0.0187012001206532	100	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL272C_p	YPL272C	YPL272C	hom	Uncharacterized	2.23992914388338	0.0125477616268482	no	113	0.0202414992889584	157	NA					Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene	biological_process	molecular_function	cellular_component
YJL129C	YJL129C	TRK1	hom	Verified	2.21984076012405	0.0132147894855834	no	114	0.0312050317021408	232	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication	cellular potassium ion homeostasis	potassium ion transmembrane transporter activity	membrane raft|integral to membrane|plasma membrane
YJR010C-A	YJR010C-A	SPC1	hom	Verified	2.20956165416448	0.0135677995281819	no	115	0.0141171554956323	118	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress	signal peptide processing|protein targeting to ER	molecular_function	signal peptidase complex
YNL127W	YNL127W	FAR11	hom	Verified	2.20414154268204	0.0137571956829489	no	116	0.0290804422517335	195	NA	FT	CELL CYCLE|SIGNALING			Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	cellular_component
YPL042C	YPL042C	SSN3	hom	Verified	2.20092300838655	0.0138707373935653	no	117	0.0318926413250634	194	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression	phosphorylation of RNA polymerase II C-terminal domain|negative regulation of transcription from RNA polymerase II promoter|negative regulation of filamentous growth|protein phosphorylation|protein destabilization|nuclear-transcribed mRNA catabolic process, non-stop decay|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II carboxy-terminal domain kinase activity|protein kinase activity|cyclin-dependent protein kinase activity	mediator complex
YDL071C_d	YDL071C	YDL071C	hom	Dubious	2.19959527684534	0.0139178112959755	no	118	0.0221133250010801	135	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W	Unknown	Unknown	Unknown
YPL069C	YPL069C	BTS1	hom	Verified	2.19959493813181	0.013917823322407	no	119	0.102875755459245	497	NA	FF|FT	PROTEIN LOCALIZATION|LIPID METABOLISM	MITOCHONDRION		Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic	terpenoid biosynthetic process	farnesyltranstransferase activity	mitochondrion
YBL107C	YBL107C	MIC23	hom	Verified	2.19715415590229	0.01400471923075	no	120	0.0191423963306567	117	NA					Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C)	biological_process	molecular_function	cytoplasm
YOL138C	YOL138C	RTC1	hom	Verified	2.19438296906285	0.0141039446147718	no	121	0.0149248124540765	100	NA					Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif	biological_process	molecular_function	ribosome|fungal-type vacuole|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YLR139C	YLR139C	SLS1	hom	Verified	2.18890518182109	0.0143018661876345	no	122	0.0274040931479114	173	NA	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery	aerobic respiration|mitochondrial translation	molecular_function	mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YBR144C_d	YBR144C	YBR144C	hom	Dubious	2.18079417158538	0.0145993219339142	no	123	0.00770372057756661	76	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene	Unknown	Unknown	Unknown
YGL144C	YGL144C	ROG1	hom	Verified	2.17989882623096	0.0146324809838598	no	124	0.0175422632076266	94	NA	FT	LIPID METABOLISM			Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication	cellular lipid metabolic process	lipase activity	cellular_component
YPL273W	YPL273W	SAM4	hom	Verified	2.17802821078559	0.0147019682681943	no	125	0.0105452497583909	105	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio	homocysteine metabolic process|L-methionine biosynthetic process from S-adenosylmethionine|S-adenosylhomocysteine metabolic process	homocysteine S-methyltransferase activity	nucleus|cytoplasm
YPR009W	YPR009W	SUT2	hom	Verified	2.17021871990189	0.014995140297923	no	126	0.0195271753706592	100	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p	positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|sequence-specific DNA binding	nucleus
YPR093C	YPR093C	ASR1	hom	Verified	2.16984028090187	0.0150094738397085	no	127	0.0129243338276279	105	NA	FT		NUCLEUS		Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein	response to ethanol|protein ubiquitination	ubiquitin-protein ligase activity	nucleus|cytoplasm
YNL097C	YNL097C	PHO23	hom	Verified	2.16765846215384	0.0150923410440784	no	128	0.0137325904924048	144	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|chromatin modification|positive regulation of transcription from RNA polymerase II promoter	methylated histone residue binding	histone deacetylase complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YDR263C	YDR263C	DIN7	hom	Verified	2.16514058247654	0.0151884604687845	no	129	0.017526670660421	115	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination	DNA repair	nuclease activity	mitochondrion
YKR100C	YKR100C	SKG1	hom	Verified	2.16319628851793	0.0152630428069431	no	130	0.0184125400695518	146	NA	FT	CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell	fungal-type cell wall organization	molecular_function	incipient cellular bud site|cellular bud|cellular bud tip
YLR322W_d	YLR322W	VPS65	hom	Dubious	2.15942148470576	0.015408741287539	no	131	0.0235452601941545	173	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth	Unknown	Unknown	Unknown
YGR151C_d	YGR151C	YGR151C	hom	Dubious	2.15623743428211	0.0155325649413309	no	132	0.0155021494143189	127	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress	Unknown	Unknown	Unknown
YNL250W	YNL250W	RAD50	hom	Verified	2.15461912145483	0.0155958257344346	no	133	0.00943129183288196	108	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress	base-excision repair|meiotic DNA double-strand break processing|telomere maintenance via recombination|meiosis|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|negative regulation of endodeoxyribonuclease activity	double-stranded DNA binding|single-stranded telomeric DNA binding|ATPase activity|double-stranded telomeric DNA binding|G-quadruplex DNA binding|telomeric DNA binding|adenylate kinase activity	mitochondrion|nucleus|Mre11 complex
YBR024W	YBR024W	SCO2	hom	Verified	2.15178599182826	0.0157071068210964	no	134	0.0138968488225618	117	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication	copper ion transport	thioredoxin peroxidase activity	mitochondrial envelope|mitochondrion
YJL134W	YJL134W	LCB3	hom	Verified	2.14938013491378	0.0158021394228703	no	135	0.0162436725639379	108	NA	FT	LIPID METABOLISM|SIGNALING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication	calcium-mediated signaling|sphingolipid biosynthetic process	sphingosine-1-phosphate phosphatase activity	integral to membrane|endoplasmic reticulum
YDR408C	YDR408C	ADE8	hom	Verified	2.14583923248292	0.0159429036826531	no	136	0.0198271688498558	119	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process|adenine biosynthetic process	phosphoribosylglycinamide formyltransferase activity	nucleus|cytoplasm
YJR113C	YJR113C	RSM7	hom	Verified	2.14480090677729	0.0159843843438955	no	137	0.0304922878278161	194	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YGR040W	YGR040W	KSS1	hom	Verified	2.14437173188209	0.0160015566979941	no	138	0.0108226896714983	109	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains	pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|negative regulation of sequence-specific DNA binding transcription factor activity|protein phosphorylation|invasive growth in response to glucose limitation	MAP kinase activity|protein kinase activity|transcription factor binding	nucleus
YNR065C_p	YNR065C	YNR065C	hom	Uncharacterized	2.13670833446177	0.0163108608509944	no	139	0.0167375923395315	139	NA					Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene	biological_process	molecular_function	integral to membrane
YBL088C	YBL088C	TEL1	hom	Verified	2.13523272062073	0.0163710027099979	no	140	0.0145645319711372	93	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)	double-strand break repair|histone phosphorylation|telomere maintenance|response to DNA damage stimulus|phosphorylation|DNA damage induced protein phosphorylation	protein kinase activity|telomeric DNA binding	mitochondrion|nucleus
YNL140C_p	YNL140C	YNL140C	hom	Uncharacterized	2.12948454561547	0.0166070960824788	no	141	0.02653936705945	170	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C	biological_process	molecular_function	cellular_component
YCR099C_p	YCR099C	YCR099C	hom	Uncharacterized	2.12717429951856	0.0167028018458141	no	142	0.0173469776354745	171	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YIL017C	YIL017C	VID28	hom	Verified	2.12493321952853	0.0167960927932107	no	143	0.0210466798846004	100	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process|ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	nucleus|GID complex|cytoplasm
YPR193C	YPR193C	HPA2	hom	Verified	2.12268984473136	0.0168899252772597	no	144	0.0128113578597036	133	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION			Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity	protein homotetramerization|histone acetylation	histone acetyltransferase activity|protein homodimerization activity	cytoplasm
YBL104C	YBL104C	SEA4	hom	Verified	2.10185348035944	0.0177830563282451	no	145	0.0303234663990406	212	NA					Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites	biological_process	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane|cytoplasm
YIL077C_p	YIL077C	YIL077C	hom	Uncharacterized	2.10108563046903	0.0178167250296258	no	146	0.0255084405874416	132	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	biological_process	molecular_function	mitochondrion
YOR371C	YOR371C	GPB1	hom	Verified	2.09825109043211	0.0179414852869759	no	147	0.0145946190186447	124	NA	FT	SIGNALING|PROTEOLYSIS	PLASMA MEMBRANE		Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication	positive regulation of Ras protein signal transduction|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of phosphorylation|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|invasive growth in response to glucose limitation|negative regulation of Ras protein signal transduction|protein polyubiquitination	cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding	plasma membrane|cytoplasm
YOR164C	YOR164C	GET4	hom	Verified	2.09439548824974	0.0181123821756841	no	148	0.026429026458327	136	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20	protein insertion into ER membrane|posttranslational protein targeting to membrane	molecular_function	TRC complex|cytoplasm
YML030W	YML030W	RCF1	hom	Verified	2.09275508762385	0.0181855114589228	no	149	0.0161971454988092	107	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast	mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain supercomplex assembly	molecular_function	mitochondrion|mitochondrial respiratory chain supercomplex|integral to mitochondrial inner membrane|mitochondrial respiratory chain complex IV
YGL035C	YGL035C	MIG1	hom	Verified	2.07930288545436	0.0187947600454289	no	150	0.025535658675129	183	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|NUCLEUS		Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion	negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus|nuclear envelope lumen|cytoplasm
YOR025W	YOR025W	HST3	hom	Verified	2.07762303040813	0.0188720466392535	no	151	0.0182385419532782	139	NA	FT	KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism	short-chain fatty acid metabolic process|histone deacetylation|chromatin silencing at telomere	histone deacetylase activity|DNA binding	nucleus
YDR515W	YDR515W	SLF1	hom	Verified	2.07708456747419	0.0188968773386381	no	152	0.0199806587659951	141	NA	FT	TRANSLATION|ION HOMEOSTASIS|ION HOMEOSTASIS			RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cellular copper ion homeostasis|regulation of translation	RNA binding	polysome|cytoplasm
YFL011W	YFL011W	HXT10	hom	Verified	2.07532471308691	0.0189782252688193	no	153	0.0254851403939945	142	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Putative hexose transporter, expressed at low levels and expression is repressed by glucose	hexose transport|transmembrane transport	galactose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YBR043C	YBR043C	QDR3	hom	Verified	2.07199064264192	0.0191331569270657	no	154	0.0131651741673167	103	NA	FT		PLASMA MEMBRANE		Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin	drug transmembrane transport|polyamine homeostasis	drug transmembrane transporter activity|polyamine transmembrane transporter activity	integral to membrane|plasma membrane
YPR084W_p	YPR084W	YPR084W	hom	Uncharacterized	2.06773993775926	0.0193322421288058	no	155	0.0178507617637545	135	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR337W	YOR337W	TEA1	hom	Verified	2.06340160434265	0.0195372438287138	no	156	0.0203636984981811	165	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein	transcription, DNA-dependent	sequence-specific DNA binding|DNA binding	nucleus
YOR121C_d	YOR121C	YOR121C	hom	Dubious	2.04506832204639	0.0204240614145415	no	157	0.0173670002739796	137	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W	Unknown	Unknown	Unknown
YDR070C	YDR070C	FMP16	hom	Verified	2.04136822102105	0.0206071203637253	no	158	0.0142771071065376	131	NA	FT		MITOCHONDRION		Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrion
YGL121C	YGL121C	GPG1	hom	Verified	2.04003916920297	0.0206732123142569	no	159	0.0118137119748096	86	NA	FT	SIGNALING			Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing	signal transduction|invasive growth in response to glucose limitation	signal transducer activity	cellular_component
YLR354C	YLR354C	TAL1	hom	Verified	2.03745508869874	0.0208022290894832	no	160	0.0340037485457594	138	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate	pentose-phosphate shunt	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	nucleus|cytoplasm
YCL034W	YCL034W	LSB5	hom	Verified	2.03620395397321	0.0208649396975878	no	161	0.0316131928294513	113	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat	endocytosis|actin filament organization|actin cortical patch localization|actin cytoskeleton organization	molecular_function	cell cortex|cytoplasm|actin cortical patch
YBR073W	YBR073W	RDH54	hom	Verified	2.03383665490019	0.0209840337256854	no	162	0.025067326849219	155	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p	DNA geometric change|heteroduplex formation|meiotic sister chromatid segregation|reciprocal meiotic recombination|double-strand break repair via break-induced replication	DNA-dependent ATPase activity|DNA translocase activity	nucleus
YIL105C	YIL105C	SLM1	hom	Verified	2.03042359320473	0.0211567502375372	no	163	0.0198085461399447	141	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION	MITOCHONDRION|PLASMA MEMBRANE		Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol binding|sphingolipid binding	eisosome|mitochondrion|membrane raft|plasma membrane|cytoplasm
YOR144C	YOR144C	ELG1	hom	Verified	2.02117475239691	0.0216308391531834	no	164	0.0189675756401579	168	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication	negative regulation of DNA recombination|negative regulation of transposition, RNA-mediated|telomere maintenance|double-strand break repair via homologous recombination|DNA-dependent DNA replication|mitotic sister chromatid cohesion	chromatin binding	Elg1 RFC-like complex|mitochondrion|nucleus|cytoplasm
YPL004C	YPL004C	LSP1	hom	Verified	2.0143924954617	0.02198417082073	no	165	0.0171332829965934	92	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family	negative regulation of protein kinase activity|endocytosis|response to heat	lipid binding	mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YLR446W_p	YLR446W	YLR446W	hom	Uncharacterized	2.01131536095865	0.022146078499613	no	166	0.0187799293354154	172	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene	biological_process	molecular_function	cellular_component
YGR039W_d	YGR039W	YGR039W	hom	Dubious	2.00747665418075	0.0223494670084318	no	167	0.019111187490923	139	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722	Unknown	Unknown	Unknown
YNL264C	YNL264C	PDR17	hom	Verified	2.004747605889	0.0224950181746335	no	168	0.0236569103985979	145	NA	FT	LIPID METABOLISM			Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition	Golgi to plasma membrane protein transport|phosphatidylserine metabolic process|response to drug|sterol biosynthetic process|Unknown|phospholipid transport|phospholipid biosynthetic process	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	endosome|cell periphery|cytosol|cytoplasm
YJL044C	YJL044C	GYP6	hom	Verified	2.00203245615386	0.0226406204795606	no	169	0.0243015321382595	142	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM			GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport	intracellular protein transport	GTPase activator activity	endosome|clathrin-coated vesicle
YDR101C	YDR101C	ARX1	hom	Verified	1.99996607285895	0.0227519637694631	no	170	0.0270822951531929	108	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS	NUCLEUS	RIBOSOME	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex	ribosomal large subunit biogenesis	molecular_function	nucleoplasm|cytosolic large ribosomal subunit|cytoplasm
YBL060W	YBL060W	YEL1	hom	Verified	1.99734619808291	0.0228937940236511	no	171	0.0270653585319732	171	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip	positive regulation of phosphatidylinositol biosynthetic process|protein localization|actin cortical patch localization	ARF guanyl-nucleotide exchange factor activity	cellular bud neck|cellular bud tip|cytoplasm
YBL087C	YBL087C	RPL23A	hom	Verified	1.99006766355536	0.0232917411667538	no	172	0.0219498436046351	114	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YMR063W	YMR063W	RIM9	hom	Verified	1.98889255651172	0.0233565317716243	no	173	0.0606152497032809	336	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;	ascospore formation	molecular_function	integral to membrane
YGL180W	YGL180W	ATG1	hom	Verified	1.98692099973317	0.0234655760494342	no	174	0.0189287578300515	123	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p	piecemeal microautophagy of nucleus|mitochondrion degradation|protein phosphorylation|CVT pathway|autophagic vacuole assembly	protein serine/threonine kinase activity|protein kinase activity	cytosol|pre-autophagosomal structure|Atg1p signaling complex
YER077C_p	YER077C	YER077C	hom	Uncharacterized	1.98479780529008	0.0235834858915743	no	175	0.0477714584553074	238	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport	biological_process	molecular_function	mitochondrion
YKL114C	YKL114C	APN1	hom	Verified	1.98461848234205	0.0235934672243079	no	176	0.0451890459344316	309	NA	FF|FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine	base-excision repair	3'-tyrosyl-DNA phosphodiesterase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity	mitochondrion|nucleus
YCL001W-B_p	YCL001W-B	YCL001W-B	hom	Uncharacterized	1.98128363376743	0.0237797373536767	no	177	0.0276509461744956	101	NA					Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDR509W_d	YDR509W	YDR509W	hom	Dubious	1.97633646602831	0.024058341056262	no	178	0.0271035290535036	200	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR338W_d	YLR338W	OPI9	hom	Dubious	1.96889621963061	0.0244825048822937	no	179	0.0620212820336236	343	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C	Unknown	Unknown	Unknown
YOL145C	YOL145C	CTR9	hom	Verified	1.96312551923466	0.024815795491899	no	180	0.0413234016293328	272	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats	transcription elongation from RNA polymerase I promoter|mRNA 3'-end processing|regulation of chromatin silencing at telomere|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|regulation of transcription initiation from RNA polymerase II promoter|snoRNA 3'-end processing|Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	RNA polymerase II core binding|triplex DNA binding|RNA polymerase II transcription factor binding transcription factor activity	transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YDL156W	YDL156W	CMR1	hom	Verified	1.95943790463615	0.0250307626322016	no	181	0.0305767411651819	144	NA	FT		NUCLEUS|CHROMOSOME		DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS	biological_process	DNA binding	nuclear chromatin|nucleus|cytoplasm
YBR064W_d	YBR064W	YBR064W	hom	Dubious	1.95921094521846	0.025044043926435	no	182	0.0181572050331284	140	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C	Unknown	Unknown	Unknown
YHR154W	YHR154W	RTT107	hom	Verified	1.95880166413619	0.0250680093186453	no	183	0.0402300747067325	234	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress	negative regulation of transposition, RNA-mediated|double-strand break repair	molecular_function	Cul8-RING ubiquitin ligase complex|nucleus
YMR084W_p	YMR084W	YMR084W	hom	Uncharacterized	1.95644677056599	0.0252062735598143	no	184	0.0282664734691815	191	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1	biological_process	molecular_function	cellular_component
YDR435C	YDR435C	PPM1	hom	Verified	1.95233585863578	0.0254491713918568	no	185	0.0466190022380805	306	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS			Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits	cellular protein complex assembly|C-terminal protein methylation	protein C-terminal leucine carboxyl O-methyltransferase activity	cellular_component
YHR029C	YHR029C	YHI9	hom	Verified	1.94798882678594	0.025708150048165	no	186	0.0322908281891087	167	NA	FT	SIGNALING			Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production	endoplasmic reticulum unfolded protein response	molecular_function	cellular_component
YOR231W	YOR231W	MKK1	hom	Verified	1.94617005253785	0.0258171579902162	no	187	0.0237694402270707	151	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH		MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication	signal transduction|peroxisome degradation|protein phosphorylation	protein kinase activity|MAP kinase kinase activity	cellular bud tip
YBL075C	YBL075C	SSA3	hom	Verified	1.94416236582293	0.0259379372516419	no	188	0.0300191704302512	242	NA	FT	PROTEIN LOCALIZATION			ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity	cytosol
YBR042C	YBR042C	CST26	hom	Verified	1.94085250406991	0.026138085206303	no	189	0.0229687971262329	165	NA	FT	LIPID METABOLISM			Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication	phospholipid biosynthetic process	transferase activity, transferring acyl groups	lipid particle
YBR057C	YBR057C	MUM2	hom	Verified	1.93839585395377	0.0262874729366265	no	190	0.0285360446003814	150	NA	FT	CELL CYCLE			Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex	premeiotic DNA replication	molecular_function	cytoplasm
YGL147C	YGL147C	RPL9A	hom	Verified	1.93560711743729	0.0264579189980739	no	191	0.0272489846291989	189	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR207C	YDR207C	UME6	hom	Verified	1.93486538786713	0.0265034082723954	no	192	0.0782923847348308	359	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|CHROMOSOME		Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p	spore germination|positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter during meiosis|lipid particle organization|nitrogen catabolite repression of transcription from RNA polymerase II promoter|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|repressing transcription factor binding|transcription factor binding transcription factor activity	Rpd3L-Expanded complex|Rpd3L complex
YPL182C_d	YPL182C	YPL182C	hom	Dubious	1.93161937273689	0.0267032514660598	no	193	0.0260749214612795	162	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W	Unknown	Unknown	Unknown
YGL034C_d	YGL034C	YGL034C	hom	Dubious	1.92792437544163	0.0269322666655771	no	194	0.0345490864620012	195	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR093W_d	YHR093W	AHT1	hom	Dubious	1.92304270441065	0.0272373434778841	no	195	0.0248570732355051	139	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region	Unknown	Unknown	Unknown
YMR119W	YMR119W	ASI1	hom	Verified	1.91861548824419	0.0275165070012301	no	196	0.04662659903671	220	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication	ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	integral to membrane|nuclear inner membrane|endoplasmic reticulum membrane
YMR258C	YMR258C	ROY1	hom	Verified	1.91584407547928	0.0276924728257804	no	197	0.0295623675536925	182	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|NUCLEUS		GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p	endocytosis|protein targeting to vacuole|negative regulation of GTPase activity	GTPase inhibitor activity	nucleus|cytoplasm
YPL041C_p	YPL041C	YPL041C	hom	Uncharacterized	1.91413047241348	0.0278017434014872	no	198	0.0265373166256026	91	NA					Protein of unknown function involved in maintenance of proper telomere length	biological_process	molecular_function	cellular_component
YGL070C	YGL070C	RPB9	hom	Verified	1.91014861989464	0.0280570402159664	no	199	0.0491167243559775	194	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE	NUCLEUS	RNA POL II, HOLOENZYME	RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription	transcription initiation from RNA polymerase II promoter|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|response to DNA damage stimulus|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity	DNA-directed RNA polymerase II, core complex
YOR064C	YOR064C	YNG1	hom	Verified	1.89769160988669	0.0288683592277451	no	200	0.0319740621361685	182	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1	histone acetylation|chromatin modification	histone acetyltransferase activity|methylated histone residue binding	NuA3 histone acetyltransferase complex
YPR017C	YPR017C	DSS4	hom	Verified	1.89413767204985	0.0291033692560328	no	201	0.0323961839817384	234	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING			Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol	post-Golgi vesicle-mediated transport	zinc ion binding|guanyl-nucleotide exchange factor activity	cytosol|membrane
YPL038W	YPL038W	MET31	hom	Verified	1.89258601931424	0.0292064722169647	no	202	0.0322872852427385	190	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication	regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YGR107W_d	YGR107W	YGR107W	hom	Dubious	1.88988398624993	0.0293867388569796	no	203	0.029438239393916	182	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR326C_d	YMR326C	YMR326C	hom	Dubious	1.88533331278033	0.0296924256384571	no	204	0.0282133470117216	146	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13	Unknown	Unknown	Unknown
YBL099W	YBL099W	ATP1	hom	Verified	1.88302675968568	0.0298483707895605	no	205	0.0374662312233451	194	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrial nucleoid|proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, catalytic core
YBR268W	YBR268W	MRPL37	hom	Verified	1.88266503068663	0.0298728886649248	no	206	0.0586492617395775	275	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOL101C	YOL101C	IZH4	hom	Verified	1.86744555993453	0.0309196962586902	no	207	0.0334133319089139	186	NA	FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress	cellular zinc ion homeostasis|cellular lipid metabolic process	metal ion binding	integral to membrane|membrane
YLR239C	YLR239C	LIP2	hom	Verified	1.86568741351994	0.0310425558195692	no	208	0.0724034261262936	348	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups	protein lipoylation	ligase activity	mitochondrion
YGR110W	YGR110W	CLD1	hom	Verified	1.86328461465207	0.0312111167932495	no	209	0.0378070540791527	106	NA	FT	LIPID METABOLISM	MITOCHONDRION		Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58	cardiolipin acyl-chain remodeling|cardiolipin metabolic process	phospholipase A2 activity	mitochondrion
YOL019W_p	YOL019W	YOL019W	hom	Uncharacterized	1.85255617822172	0.031972999207052	no	210	0.0408245987022808	197	NA	FT		PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; YOL019W has a paralog, DCV1, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane|plasma membrane|fungal-type vacuole
YDL066W	YDL066W	IDP1	hom	Verified	1.84809205774453	0.0322945132752837	no	211	0.0767892273664463	372	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes	isocitrate metabolic process|glutamate biosynthetic process	isocitrate dehydrogenase (NADP+) activity	mitochondrial nucleoid|mitochondrion
YKL133C_p	YKL133C	YKL133C	hom	Uncharacterized	1.84776137224759	0.0323184356133408	no	212	0.0430515985807586	181	NA					Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)	biological_process	molecular_function	cellular_component
YBR019C	YBR019C	GAL10	hom	Verified	1.84537005659547	0.0324918629230971	no	213	0.0269284024789202	163	NA	FT	CARBOHYDRATE METABOLISM			UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers	galactose catabolic process via UDP-galactose	aldose 1-epimerase activity|UDP-glucose 4-epimerase activity	cytosol
YJL047C	YJL047C	RTT101	hom	Verified	1.84106227963482	0.0328062162703534	no	214	0.0469634012721467	267	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p	replication fork processing|negative regulation of transposition, RNA-mediated|regulation of mitosis|nonfunctional rRNA decay|ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	Cul8-RING ubiquitin ligase complex|nucleus|cytoplasm
YPR022C_p	YPR022C	YPR022C	hom	Uncharacterized	1.84096649718242	0.0328132342401794	no	215	0.0374687545142662	150	NA	FT		NUCLEUS		Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	sequence-specific DNA binding	nucleus|cytoplasm
YDR304C	YDR304C	CPR5	hom	Verified	1.83345026950372	0.0333678188533451	no	216	0.0278440930187357	176	NA	FT		ENDOPLASMIC RETICULUM		Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER	biological_process	peptidyl-prolyl cis-trans isomerase activity	endoplasmic reticulum|cytoplasm
YLR079W	YLR079W	SIC1	hom	Verified	1.83318687474934	0.0333873925538498	no	217	0.0374922046901393	213	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1	regulation of cyclin-dependent protein kinase activity|negative regulation of macroautophagy|G1/S transition of mitotic cell cycle	cyclin-dependent protein kinase inhibitor activity	nucleus|cytoplasm
YBL091C-A	YBL091C-A	SCS22	hom	Verified	1.8290722471945	0.0336943929358883	no	218	0.0325450651379447	193	NA	FT	LIPID METABOLISM			Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication	phospholipid biosynthetic process|chromatin silencing at telomere	molecular_function	cellular_component
YGL023C	YGL023C	PIB2	hom	Verified	1.82878390651906	0.0337159934086515	no	219	0.0394441530403664	187	NA	FT	VESICLE-MEDIATED TRANSPORT	MITOCHONDRION		Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27	biological_process	molecular_function	mitochondrion
YBR151W	YBR151W	APD1	hom	Verified	1.82801191700439	0.0337738815777891	no	220	0.0304444675326659	217	NA	FT		NUCLEUS		Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YGL258W	YGL258W	VEL1	hom	Verified	1.82052748015923	0.0343393576544802	no	221	0.0542227426937103	236	NA					Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C	biological_process	molecular_function	cytosol
YKL033W-A_p	YKL033W-A	YKL033W-A	hom	Uncharacterized	1.81917209715174	0.0344425891889407	no	222	0.0539141696665261	267	NA					Putative protein of unknown function; similar to uncharacterized proteins from other fungi	biological_process	molecular_function	cellular_component
YBR119W	YBR119W	MUD1	hom	Verified	1.81786059757589	0.0345427209826354	no	223	0.0472933577501995	200	NA	FT	RNA PROCESSING	NUCLEUS		U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing	mRNA splicing, via spliceosome	U1 snRNA binding|RNA binding	U1 snRNP|U2-type prespliceosome
YNL085W	YNL085W	MKT1	hom	Verified	1.80915293994773	0.0352136232017729	no	224	0.0316743859976912	212	NA	FT	RESPONSE TO DNA DAMAGE|TRANSLATION			Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress	positive regulation of translation|interspecies interaction between organisms|response to DNA damage stimulus	nuclease activity	polysome|cytoplasm
YBL006C	YBL006C	LDB7	hom	Verified	1.80476761280281	0.0355555272267957	no	225	0.0951531239616778	444	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions	ATP-dependent chromatin remodeling|cell wall mannoprotein biosynthetic process|nucleosome disassembly|transcription elongation from RNA polymerase II promoter	DNA translocase activity	RSC complex
YFR043C	YFR043C	IRC6	hom	Verified	1.80032638968132	0.0359045581644133	no	226	0.037983091958398	225	NA					Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YFL031W	YFL031W	HAC1	hom	Verified	1.79998701901828	0.0359313439754608	no	227	0.028212538307329	202	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING	NUCLEUS		Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress	endoplasmic reticulum unfolded protein response|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|negative regulation of transcription from RNA polymerase II promoter during meiosis|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YBR203W	YBR203W	COS111	hom	Verified	1.79829482164465	0.0360651499624539	no	228	0.0554554522814172	224	NA	FT	SIGNALING	MITOCHONDRION		Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	signal transduction	molecular_function	mitochondrion
YPL171C	YPL171C	OYE3	hom	Verified	1.79724427904869	0.0361484239277693	no	229	0.0386406987528572	219	NA	FT	OXIDATION-REDUCTION PROCESS			Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death	apoptotic process	NADPH dehydrogenase activity	cellular_component
YHR050W-A_p	YHR050W-A	YHR050W-A	hom	Uncharacterized	1.79679474150419	0.0361841057472511	no	230	0.0349900694079783	176	NA					Protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YGL078C	YGL078C	DBP3	hom	Verified	1.79646661100589	0.0362101691457379	no	231	0.0441497022395061	196	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype	endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RNA-dependent ATPase activity	nucleolus|preribosome, large subunit precursor
YKR067W	YKR067W	GPT2	hom	Verified	1.7932649619027	0.0364652835581681	no	232	0.0493240023067473	266	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen	phospholipid biosynthetic process	glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity	integral to membrane|lipid particle|endoplasmic reticulum|cytoplasm
YGL010W_p	YGL010W	YGL010W	hom	Uncharacterized	1.79224981706113	0.0365464789598016	no	233	0.0351476141696631	190	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; YGL010W is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YBR133C	YBR133C	HSL7	hom	Verified	1.790694098818	0.0366711986090234	no	234	0.050644542162103	273	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION	SITE OF POLARIZED GROWTH		Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress	G2/M transition of mitotic cell cycle|regulation of cell cycle	protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity	cellular bud neck
YDL025C	YDL025C	RTK1	hom	Verified	1.7865649514031	0.0370039153391385	no	235	0.0647053982531113	248	NA	FT	PROTEIN PHOSPHORYLATION			Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress	biological_process	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YMR312W	YMR312W	ELP6	hom	Verified	1.78578990535876	0.0370666409015451	no	236	0.044827883821983	223	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	protein urmylation|regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex
YDR078C	YDR078C	SHU2	hom	Verified	1.78434148762236	0.037184096327831	no	237	0.0363813772385709	206	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function	recombinational repair|maintenance of rDNA|error-free translesion synthesis	molecular_function	Shu complex
YOR323C	YOR323C	PRO2	hom	Verified	1.78310320670501	0.0372847522752089	no	238	0.118682110907427	582	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis	proline biosynthetic process	glutamate-5-semialdehyde dehydrogenase activity	nucleus|cytoplasm
YOL107W_p	YOL107W	YOL107W	hom	Uncharacterized	1.7785959862491	0.0376530113130753	no	239	0.0312758673637419	202	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein	biological_process	molecular_function	COPI-coated vesicle|Golgi apparatus
YDR540C	YDR540C	IRC4	hom	Verified	1.77769351919558	0.0377271023334981	no	240	0.0686984899580028	347	NA	FF|FT		NUCLEUS		Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	mitotic recombination	molecular_function	nucleus|cytoplasm
YBR251W	YBR251W	MRPS5	hom	Verified	1.77434798633965	0.0380028038651249	no	241	0.071280707965789	307	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YGR070W	YGR070W	ROM1	hom	Verified	1.76874086941217	0.0384685642879465	no	242	0.0447342891740328	239	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP	small GTPase mediated signal transduction|activation of Rho GTPase activity	Rho guanyl-nucleotide exchange factor activity	intracellular
YOR332W	YOR332W	VMA4	hom	Verified	1.76821140995712	0.0385127837121115	no	243	0.0468052321468704	216	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane|integral to membrane
YJR144W	YJR144W	MGM101	hom	Verified	1.76656909673558	0.0386502101229017	no	244	0.0581899153764257	303	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	MITOCHONDRION|CHROMOSOME		Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage	DNA repair|recombinational repair|DNA strand renaturation	molecular_function	mitochondrial nucleoid|mitochondrion
YHR209W	YHR209W	CRG1	hom	Verified	1.76622254749541	0.0386792598559252	no	245	0.0389106576184934	247	NA					S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin	lipid homeostasis	mRNA binding|S-adenosylmethionine-dependent methyltransferase activity|methyltransferase activity	cellular_component
YPL089C	YPL089C	RLM1	hom	Verified	1.7660972211803	0.0386897698009735	no	246	0.058312811825489	217	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication	signal transduction|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|DNA binding, bending|sequence-specific DNA binding	nucleus
YNL081C	YNL081C	SWS2	hom	Verified	1.76276362742875	0.0389701821766282	no	247	0.0743853903493353	352	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency	regulation of sporulation resulting in formation of a cellular spore|mitochondrial translation	structural constituent of ribosome	mitochondrial small ribosomal subunit|cytoplasm
YEL044W	YEL044W	IES6	hom	Verified	1.76262301359993	0.0389820464889276	no	248	0.0526438111480823	300	NA	FT		NUCLEUS		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes	biological_process	molecular_function	nucleus
YBL031W	YBL031W	SHE1	hom	Verified	1.75726602504593	0.0394362379721755	no	249	0.0337451198249502	259	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function	mitotic spindle elongation	molecular_function	microtubule cytoskeleton|nuclear microtubule|cellular bud neck|astral microtubule|spindle
YGL125W	YGL125W	MET13	hom	Verified	1.74794734132195	0.0402365730888594	no	250	0.0451397686352339	158	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway	methionine biosynthetic process	methylenetetrahydrofolate reductase (NADPH) activity	mitochondrion
YBL106C	YBL106C	SRO77	hom	Verified	1.74433127070984	0.0405506709490948	no	251	0.0660274737409955	341	NA	FF|FT	VESICLE-MEDIATED TRANSPORT	PLASMA MEMBRANE		Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication	exocytosis|Golgi to plasma membrane transport	molecular_function	plasma membrane
YOR026W	YOR026W	BUB3	hom	Verified	1.74038769399294	0.0408954824487072	no	252	0.0396472509162669	235	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME	KINETOCHORE	Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p	mitotic cell cycle G2/M transition decatenation checkpoint|mitotic cell cycle spindle assembly checkpoint	ubiquitin binding	mitotic checkpoint complex|condensed nuclear chromosome kinetochore
YOR369C	YOR369C	RPS12	hom	Verified	1.73867933011402	0.0410455918978403	no	253	0.0408517860748132	212	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YGR053C_p	YGR053C	YGR053C	hom	Uncharacterized	1.7365037750522	0.0412373987284493	no	254	0.0401339674188652	185	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL179W	YPL179W	PPQ1	hom	Verified	1.73288136098719	0.0415583789043391	no	255	0.0415672195810964	195	NA	FT	TRANSLATION			Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors	protein dephosphorylation|regulation of translation	protein serine/threonine phosphatase activity	cytoplasm
YGL012W	YGL012W	ERG4	hom	Verified	1.73156346073676	0.0416756583370289	no	256	0.136324549045132	568	NA	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM		C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol	ergosterol biosynthetic process	delta24(24-1) sterol reductase activity	integral to membrane|endoplasmic reticulum
YPL096W	YPL096W	PNG1	hom	Verified	1.72817469854063	0.0419784542135449	no	257	0.0471634507172122	195	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS|MITOCHONDRION		Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p	misfolded or incompletely synthesized protein catabolic process|protein deglycosylation	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity	cytosol|mitochondrion|nucleus
YDR275W	YDR275W	BSC2	hom	Verified	1.72748360823381	0.0420404232730304	no	258	0.0402811759547491	189	NA					Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication	biological_process	molecular_function	lipid particle
YNL143C_p	YNL143C	YNL143C	hom	Uncharacterized	1.72408315081561	0.042346416668946	no	259	0.0554144438753463	192	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YCL048W	YCL048W	SPS22	hom	Verified	1.71873185598164	0.0428316043311932	no	260	0.0386950619308976	184	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall	ascospore wall assembly|fungal-type cell wall organization	molecular_function	plasma membrane
YDR401W_d	YDR401W	YDR401W	hom	Dubious	1.71871945156217	0.0428327342043187	no	261	0.0483062448017508	164	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR069C	YDR069C	DOA4	hom	Verified	1.71801015760643	0.0428973812724054	no	262	0.056690424352937	317	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEOLYSIS	MITOCHONDRION		Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole	protein deubiquitination|endocytosis|regulation of DNA replication|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|free ubiquitin chain depolymerization|ubiquitin homeostasis|ubiquitin-dependent protein catabolic process	endopeptidase activity|ubiquitin-specific protease activity|ubiquitin thiolesterase activity	endosome|proteasome complex|mitochondrion
YJL217W	YJL217W	REE1	hom	Verified	1.71677644078335	0.0430100135596708	no	263	0.0423425095079664	249	NA					Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle	biological_process	molecular_function	cytoplasm
YER117W	YER117W	RPL23B	hom	Verified	1.71570669552929	0.0431078693451623	no	264	0.0403216707207823	241	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YPR173C	YPR173C	VPS4	hom	Verified	1.71253842176564	0.0433987451442808	no	265	0.0696204446652565	327	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism	late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport	ATPase activity|protein homodimerization activity|ATP binding	endosome|endoplasmic reticulum|membrane|cytoplasm
YOL111C	YOL111C	MDY2	hom	Verified	1.70928865443686	0.0436987469306012	no	266	0.0650666641667602	321	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION	NUCLEUS		Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes	protein insertion into ER membrane|cell morphogenesis involved in conjugation with cellular fusion|posttranslational protein targeting to membrane	molecular_function	ribosome|TRC complex|nucleus|cytoplasm
YHR130C_d	YHR130C	YHR130C	hom	Dubious	1.70924428083549	0.0437028548236928	no	267	0.0478336895279447	195	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR191W	YLR191W	PEX13	hom	Verified	1.7081788729702	0.0438015787081878	no	268	0.0518322566156531	250	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p	protein import into peroxisome matrix, docking	protein binding, bridging	peroxisomal membrane
YMR122C_d	YMR122C	YMR122C	hom	Dubious	1.70598758396908	0.0440051956535585	no	269	0.0653545414114362	228	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR004C	YPR004C	AIM45	hom	Verified	1.70368168636136	0.0442202856696136	no	270	0.0421724808659241	255	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YNL136W	YNL136W	EAF7	hom	Verified	1.70353049994475	0.0442344176201699	no	271	0.0658473791416585	312	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A	DNA repair|histone acetylation|regulation of transcription from RNA polymerase II promoter	molecular_function	histone acetyltransferase complex|nucleus|NuA4 histone acetyltransferase complex
YGL060W	YGL060W	YBP2	hom	Verified	1.7014496281981	0.044429294464995	no	272	0.0468929478302494	298	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME	KINETOCHORE	Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication	G2/M transition of mitotic cell cycle	molecular_function	condensed nuclear chromosome kinetochore|centromere-specific nucleosome|cytoplasm
YLR148W	YLR148W	PEP3	hom	Verified	1.70006809157198	0.0445590591796588	no	273	0.103860773166479	441	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|vacuole fusion, non-autophagic|late endosome to vacuole transport|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol binding|protein binding, bridging	fungal-type vacuole membrane|HOPS complex|proteasome storage granule|CORVET complex|extrinsic to vacuolar membrane
YER158C_p	YER158C	YER158C	hom	Uncharacterized	1.69713327114654	0.0448357336319593	no	274	0.0229219136350699	171	NA					Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLR183C	YLR183C	TOS4	hom	Verified	1.69673955371178	0.0448729555717355	no	275	0.0488754079745897	214	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication	response to DNA damage stimulus	chromatin binding	nuclear chromatin|Rpd3L-Expanded complex|mitochondrion|nucleus|cytoplasm
YOL116W	YOL116W	MSN1	hom	Verified	1.69638526668503	0.0449064710330928	no	276	0.0465987975617705	221	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	nucleus
YPR184W	YPR184W	GDB1	hom	Verified	1.69438653713492	0.0450959280420927	no	277	0.044524607659696	250	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress	glycogen catabolic process	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity	mitochondrion|cytoplasm
YGL219C	YGL219C	MDM34	hom	Verified	1.69359546699736	0.0451710900125706	no	278	0.068899323574005	283	NA	FT	MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth	mitochondrion organization|phospholipid transport	molecular_function	mitochondrial outer membrane|ERMES complex|mitochondrion|cytoplasm
YOR186W_p	YOR186W	YOR186W	hom	Uncharacterized	1.69323309114784	0.0452055540865763	no	279	0.0402335430058434	201	NA					Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YER177W	YER177W	BMH1	hom	Verified	1.69267522717849	0.0452586515813968	no	280	0.0529489127738358	301	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	glycogen metabolic process|pseudohyphal growth|signal transduction involved in filamentous growth|ascospore formation|fungal-type cell wall chitin biosynthetic process|Ras protein signal transduction|DNA damage checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	DNA replication origin binding|phosphoserine binding	plasma membrane|nucleus
YGR231C	YGR231C	PHB2	hom	Verified	1.68957212759506	0.0455549210252254	no	281	0.0578374209553526	225	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation	mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging	molecular_function	mitochondrion|mitochondrial inner membrane
YGR178C	YGR178C	PBP1	hom	Verified	1.68823784751679	0.045682790336142	no	282	0.0552690550386889	298	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION	NUCLEUS|MITOCHONDRION		Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	positive regulation of translation|mRNA polyadenylation|stress granule assembly	molecular_function	mitochondrion|nucleus|polysome|cytoplasmic stress granule|cytoplasm
YER053C-A	YER053C-A	YER053C-A	hom	Verified	1.68603728891648	0.045894308688829	no	283	0.0299935574221096	195	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	endoplasmic reticulum
YML058W-A	YML058W-A	HUG1	hom	Verified	1.68465781111439	0.0460273053112811	no	284	0.0393296943758103	200	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress	cell cycle arrest|cell cycle checkpoint|response to DNA damage stimulus	molecular_function	cytoplasm
YBL013W	YBL013W	FMT1	hom	Verified	1.68175371614439	0.0463083035406701	no	285	0.0614337698615377	232	NA	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate	translational initiation|methionyl-tRNA aminoacylation	methionyl-tRNA formyltransferase activity	mitochondrion
YER099C	YER099C	PRS2	hom	Verified	1.68017169302183	0.0464619575856753	no	286	0.0462264947196176	255	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YPL053C	YPL053C	KTR6	hom	Verified	1.6791151165161	0.0465648053436288	no	287	0.0445137300717549	242	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication	fungal-type cell wall organization|protein N-linked glycosylation	mannosylphosphate transferase activity	membrane
YPL220W	YPL220W	RPL1A	hom	Verified	1.67613671447914	0.0468557083754734	no	288	0.0350664426812609	190	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR058C	YDR058C	TGL2	hom	Verified	1.6760888790876	0.0468603923648964	no	289	0.049092112317032	253	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli	triglyceride catabolic process	triglyceride lipase activity	mitochondrion
YGL002W	YGL002W	ERP6	hom	Verified	1.67520037939592	0.0469474615788537	no	290	0.0508045249780312	188	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport	molecular_function	mitochondrion|integral to membrane
YPL267W	YPL267W	ACM1	hom	Verified	1.67268667033016	0.0471944973468517	no	291	0.0569827378480268	285	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS		Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	ubiquitin-protein ligase inhibitor activity	nucleus|cytoplasm
YIL013C	YIL013C	PDR11	hom	Verified	1.6696415519065	0.0474951520639088	no	292	0.0497198635683295	255	NA	FT	NUCLEOTIDE METABOLISM			ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth	sterol transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YDR318W	YDR318W	MCM21	hom	Verified	1.66916946252519	0.0475419001092733	no	293	0.0676331087806059	325	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	COMA complex|condensed nuclear chromosome kinetochore
YBL029W_p	YBL029W	YBL029W	hom	Uncharacterized	1.66741779003556	0.0477156794264059	no	294	0.0563580083454553	227	NA	FT		NUCLEUS		Non-essential protein of unknown function	biological_process	molecular_function	nucleus|cytoplasm
YER118C	YER118C	SHO1	hom	Verified	1.66581883318623	0.0478747519281811	no	295	0.0449872322121248	192	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p	signal transduction involved in filamentous growth|establishment of cell polarity|osmosensory signaling pathway|cellular response to heat|cytokinesis	osmosensor activity|MAP-kinase scaffold activity	integral to membrane|plasma membrane|plasma membrane part|cellular bud|cellular bud neck|mating projection tip
YLR172C	YLR172C	DPH5	hom	Verified	1.66318725644806	0.0481374788704054	no	296	0.0532767266763971	265	NA					Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	diphthine synthase activity	cytoplasm
YBL038W	YBL038W	MRPL16	hom	Verified	1.66256580203183	0.0481996906822623	no	297	0.0671748282434432	331	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome|peptidyltransferase activity	mitochondrion|mitochondrial large ribosomal subunit
YCL057W	YCL057W	PRD1	hom	Verified	1.66196635859099	0.0482597599800227	no	298	0.0503279823632531	250	NA	FT	PROTEOLYSIS	MITOCHONDRION		Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress	proteolysis	metalloendopeptidase activity	mitochondrion|cytoplasm|mitochondrial intermembrane space
YGR037C	YGR037C	ACB1	hom	Verified	1.66060502686981	0.0483963993654977	no	299	0.119890956344548	517	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	NUCLEUS		Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress	long-chain fatty acid transport|chronological cell aging|fatty acid metabolic process	long-chain fatty acid transporter activity|fatty-acyl-CoA binding	extracellular region|nucleus|cytoplasm
YMR141C_d	YMR141C	YMR141C	hom	Dubious	1.65406676934622	0.0490569735370922	no	300	0.0513801873563347	207	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL047C	YIL047C	SYG1	hom	Verified	1.65327396529231	0.0491375595233611	no	301	0.0452849043791406	242	NA	FT	SIGNALING	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency	signal transduction	molecular_function	mitochondrion|integral to membrane|plasma membrane
YHR157W	YHR157W	REC104	hom	Verified	1.64865352938227	0.0496093177802398	no	302	0.0415334859678351	243	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YBR171W	YBR171W	SEC66	hom	Verified	1.64856206173102	0.0496186932155803	no	303	0.127171433947676	513	NA	FF|FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	posttranslational protein targeting to membrane, translocation|filamentous growth	protein transporter activity	integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YNL322C	YNL322C	KRE1	hom	Verified	1.64711211444005	0.049767501763482	no	304	0.0555433797761476	287	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall|integral to membrane
YBL090W	YBL090W	MRP21	hom	Verified	1.64626808403576	0.0498542886813169	no	305	0.0711390525604748	310	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences	mitochondrial translational initiation|mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YER161C	YER161C	SPT2	hom	Verified	1.64392429688821	0.0500959203311961	no	306	0.0700109029200841	314	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION	NUCLEUS		Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins	negative regulation of transcription from RNA polymerase II promoter|chromatin organization|RNA polyadenylation|transcription elongation from RNA polymerase II promoter	DNA binding|DNA secondary structure binding	nucleus
YHL013C	YHL013C	OTU2	hom	Verified	1.64178941889943	0.0503168263236689	no	307	0.0398654081656318	240	NA					Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|cytoplasm
YIL002C	YIL002C	INP51	hom	Verified	1.63719793633082	0.0507945590568982	no	308	0.0749798267510797	330	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	CYTOSKELETON		Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth	phosphatidylinositol dephosphorylation	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	membrane|cytoplasm
YNR057C	YNR057C	BIO4	hom	Verified	1.63450042342986	0.0510769087036362	no	309	0.0623886233156192	286	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM			Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels	biotin biosynthetic process	dethiobiotin synthase activity	cytoplasm
YPL025C_d	YPL025C	YPL025C	hom	Dubious	1.63258532282299	0.0512781200839964	no	310	0.0565664860754749	259	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR261C_d	YLR261C	VPS63	hom	Dubious	1.63111357860194	0.0514331780193106	no	311	0.142816818881223	497	NA	FF				Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YJL126W	YJL126W	NIT2	hom	Verified	1.62688736404841	0.0518805110697317	no	312	0.0515408136910657	262	NA					Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member	biological_process	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	cellular_component
YIL036W	YIL036W	CST6	hom	Verified	1.62468185293901	0.052115183014675	no	313	0.0379671259404005	256	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication	cellular response to carbon dioxide|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|DNA metabolic process	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YLR295C	YLR295C	ATP14	hom	Verified	1.623668914349	0.0522232444141142	no	314	0.0743731379630695	304	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress	cristae formation|mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YPL111W	YPL111W	CAR1	hom	Verified	1.61927045028717	0.0526945428413452	no	315	0.0595593046613621	293	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|SITE OF POLARIZED GROWTH		Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance	regulation of ornithine metabolic process|arginine catabolic process to ornithine	manganese ion binding|arginase activity|ornithine carbamoyltransferase inhibitor activity|zinc ion binding	cytosol|nucleus|mating projection tip|cytoplasm
YER088C	YER088C	DOT6	hom	Verified	1.61912194672288	0.0527105138043872	no	316	0.0551041698930609	322	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	chromatin silencing at rDNA|filamentous growth|regulation of transcription from RNA polymerase II promoter|unidimensional cell growth|chromatin silencing at telomere	sequence-specific DNA binding	Rpd3L-Expanded complex|nucleus|Rpd3L complex|cytoplasm
YFR040W	YFR040W	SAP155	hom	Verified	1.61731572558196	0.0529050732521475	no	317	0.0607863952407579	296	NA	FT	CELL CYCLE			Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress	G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	cytoplasm
YOL118C_d	YOL118C	YOL118C	hom	Dubious	1.61697966576222	0.0529413351418258	no	318	0.0617419823404264	240	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL071W	YGL071W	AFT1	hom	Verified	1.61466011895407	0.0531921592602025	no	319	0.162333650573361	610	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION	NUCLEUS		Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|meiotic chromosome segregation|positive regulation of iron ion transport|establishment of mitotic sister chromatid cohesion|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus|cytoplasm
YNL122C_p	YNL122C	YNL122C	hom	Uncharacterized	1.60991844336238	0.0537078310282854	no	320	0.0492278153123321	268	NA	FT	TRANSLATION	MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene	biological_process	molecular_function	mitochondrion
YER019W	YER019W	ISC1	hom	Verified	1.60906538794609	0.053801022285769	no	321	0.0602544300260921	291	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance	response to salt stress|ceramide biosynthetic process|sphingolipid catabolic process	inositol phosphosphingolipid phospholipase activity	mitochondrion|endoplasmic reticulum|integral to mitochondrial outer membrane
YIL098C	YIL098C	FMC1	hom	Verified	1.60283879135367	0.0544851250385664	no	322	0.0623695748528376	299	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p	mitochondrial proton-transporting ATP synthase complex assembly	molecular_function	mitochondrion|mitochondrial matrix
YLR432W	YLR432W	IMD3	hom	Verified	1.60220177579054	0.0545554987622859	no	323	0.0761791558198696	317	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM			Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed	GTP biosynthetic process	IMP dehydrogenase activity	plasma membrane|cytoplasm
YDR372C	YDR372C	VPS74	hom	Verified	1.60201648898585	0.0545759816451107	no	324	0.0787573542509499	326	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33	retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum unfolded protein response|protein localization to Golgi apparatus	enzyme binding|phosphatidylinositol-4-phosphate binding	cytosol|Golgi apparatus|nucleus|extrinsic to membrane|cytoplasm
YDR310C	YDR310C	SUM1	hom	Verified	1.59988356844274	0.0548122075880592	no	325	0.0658160464985493	270	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS		Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint	negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter during mitosis|DNA replication initiation|chromatin silencing at silent mating-type cassette	DNA replication origin binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus
YIL157C	YIL157C	COA1	hom	Verified	1.59860143536814	0.0549545953021727	no	326	0.0529090467766225	293	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly	mitochondrial respiratory chain complex IV assembly	molecular_function	integral to mitochondrial membrane|mitochondrion|integral to mitochondrial inner membrane
YGR125W_p	YGR125W	YGR125W	hom	Uncharacterized	1.59464403927368	0.0553959292901281	no	327	0.0562394715430546	282	NA					Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YFL032W_d	YFL032W	YFL032W	hom	Dubious	1.59393280398288	0.0554755430561672	no	328	0.0667554504672144	300	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene	Unknown	Unknown	Unknown
YIL025C_d	YIL025C	YIL025C	hom	Dubious	1.59178445969191	0.055716571555049	no	329	0.0808679104869594	338	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL064W	YIL064W	SEE1	hom	Verified	1.58947316278096	0.0559768041635377	no	330	0.0667177640708944	294	NA	FT	VESICLE-MEDIATED TRANSPORT			Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport	vesicle-mediated transport|peptidyl-lysine dimethylation	protein-lysine N-methyltransferase activity	cytoplasm
YBR017C	YBR017C	KAP104	hom	Verified	1.58930900263209	0.0559953236209332	no	331	0.0485967051504153	258	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE	SITE OF POLARIZED GROWTH		Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis	protein import into nucleus|cell cycle|mRNA-binding (hnRNP) protein import into nucleus|transcription factor import into nucleus	nuclear localization sequence binding	cytosol|integral to membrane|cellular bud neck|cellular bud tip
YDL044C	YDL044C	MTF2	hom	Verified	1.58570076120147	0.056403603211495	no	332	0.0683929513929143	317	NA	FT	RNA PROCESSING|TRANSLATION	MITOCHONDRION		Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription	cytoplasmic translation|mRNA processing	RNA binding	mitochondrion
YFR010W	YFR010W	UBP6	hom	Verified	1.58341244708727	0.0566637439044245	no	333	0.0973150870161924	382	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance	protein deubiquitination	ubiquitin-specific protease activity	proteasome complex|proteasome regulatory particle
YNL204C	YNL204C	SPS18	hom	Verified	1.58276513939246	0.0567375025474917	no	334	0.0660746805421371	306	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation	sporulation resulting in formation of a cellular spore	molecular_function	cellular_component
YDR285W	YDR285W	ZIP1	hom	Verified	1.57915435662851	0.0571503281685971	no	335	0.0606576651097462	268	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate	synapsis|reciprocal meiotic recombination	chromatin binding|SUMO polymer binding	transverse filament
YLR138W	YLR138W	NHA1	hom	Verified	1.57832656320297	0.057245303237705	no	336	0.0464247313751955	217	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH	cellular potassium ion homeostasis|cellular monovalent inorganic cation homeostasis|response to osmotic stress	cation:cation antiporter activity|sodium:hydrogen antiporter activity	membrane raft|integral to membrane|plasma membrane
YKL076C_d	YKL076C	PSY1	hom	Dubious	1.57641849189895	0.0574646947518608	no	337	0.0602731065286886	293	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C	Unknown	Unknown	Unknown
YGL025C	YGL025C	PGD1	hom	Verified	1.57504327938086	0.0576232275069115	no	338	0.125022284639784	477	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity	core mediator complex
YDR222W_p	YDR222W	YDR222W	hom	Uncharacterized	1.57356958998389	0.0577934941257851	no	339	0.0788442223201825	306	NA	FT	RESPONSE TO OXIDATIVE STRESS			Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YBR131W	YBR131W	CCZ1	hom	Verified	1.57323154004822	0.0578326073422961	no	340	0.0547521612678946	301	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway	autophagy|autophagic vacuole fusion|vacuolar transport|vesicle docking|protein targeting to vacuole	guanyl-nucleotide exchange factor activity	Mon1-Ccz1 complex|membrane
YHR032W	YHR032W	ERC1	hom	Verified	1.56684160262284	0.0585758601922325	no	341	0.0611109562892385	239	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine	S-adenosylmethionine biosynthetic process|transmembrane transport	antiporter activity	integral to membrane
YGR035C_p	YGR035C	YGR035C	hom	Uncharacterized	1.56254218305971	0.0590801582762316	no	342	0.044287930873961	219	NA					Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	biological_process	molecular_function	cellular_component
YOR097C_p	YOR097C	YOR097C	hom	Uncharacterized	1.56215621151958	0.0591255966781671	no	343	0.0767739980731689	328	NA					Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene	biological_process	molecular_function	cellular_component
YJL080C	YJL080C	SCP160	hom	Verified	1.5602206285902	0.0593538762032596	no	344	0.0526752471637508	289	NA	FT	CELL CYCLE|SIGNALING|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins	meiotic telomere clustering|pheromone-dependent signal transduction involved in conjugation with cellular fusion|chromosome segregation|intracellular mRNA localization|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	G-protein alpha-subunit binding|RNA binding	endoplasmic reticulum membrane|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YHR203C	YHR203C	RPS4B	hom	Verified	1.55899699202904	0.059498546050017	no	345	0.0832505729933248	315	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YER045C	YER045C	ACA1	hom	Verified	1.55696823697312	0.0597390134210559	no	346	0.0508062176412812	239	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDL168W	YDL168W	SFA1	hom	Verified	1.55641502900263	0.0598047168472039	no	347	0.0876042612470709	286	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress	furaldehyde metabolic process|formaldehyde catabolic process|amino acid catabolic process to alcohol via Ehrlich pathway	S-(hydroxymethyl)glutathione dehydrogenase activity|hydroxymethylfurfural reductase (NADH) activity|alcohol dehydrogenase (NAD) activity	mitochondrion|cytoplasm
YJL191W	YJL191W	RPS14B	hom	Verified	1.55465407638331	0.0600142386868597	no	348	0.0721661126310544	313	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome|SSU rRNA binding	small-subunit processome|cytosolic small ribosomal subunit
YOL033W	YOL033W	MSE1	hom	Verified	1.55346218881611	0.0601563778686714	no	349	0.0866951479371526	336	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated	mitochondrial glutamyl-tRNA aminoacylation|glutamyl-tRNA aminoacylation|mitochondrial translation	glutamate-tRNA(Gln) ligase activity|glutamate-tRNA ligase activity	mitochondrion
YOL003C	YOL003C	PFA4	hom	Verified	1.55181242351443	0.0603535562168521	no	350	0.0618098418967186	260	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases	protein palmitoylation	palmitoyltransferase activity	integral to membrane|endoplasmic reticulum
YIL055C_p	YIL055C	YIL055C	hom	Uncharacterized	1.55082978121981	0.0604712408097752	no	351	0.0604371978589885	251	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YEL024W	YEL024W	RIP1	hom	Verified	1.54254786741497	0.0614702576569959	no	352	0.0854130039364333	340	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|mitochondrial respiratory chain complex III
YDL045W-A	YDL045W-A	MRP10	hom	Verified	1.54152130024899	0.0615949814784788	no	353	0.0935864453600056	310	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs	mitochondrial translation|mitochondrial respiratory chain complex assembly	structural constituent of ribosome	mitochondrial small ribosomal subunit
YOR024W_d	YOR024W	YOR024W	hom	Dubious	1.54099531171385	0.0616589635118875	no	354	0.0595838726950581	215	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL089C_d	YNL089C	YNL089C	hom	Dubious	1.54058881389825	0.0617084460549099	no	355	0.059155727741628	308	NA					Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins	Unknown	Unknown	Unknown
YGR015C_p	YGR015C	YGR015C	hom	Uncharacterized	1.53770074226976	0.0620609010428903	no	356	0.0721789638056068	264	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion
YPL188W	YPL188W	POS5	hom	Verified	1.5376175928833	0.0620710716554089	no	357	0.0619406513698183	317	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress	cellular response to oxidative stress|NADP biosynthetic process	NADH kinase activity	mitochondrion|mitochondrial matrix
YPR155C	YPR155C	NCA2	hom	Verified	1.53587910778467	0.0622840165182192	no	358	0.047216606959639	250	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p	mRNA metabolic process|aerobic respiration	molecular_function	mitochondrial outer membrane|mitochondrion
YGL115W	YGL115W	SNF4	hom	Verified	1.53557559326933	0.0623212519829559	no	359	0.0806129310159434	372	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE		Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress	positive regulation of gluconeogenesis|peroxisome organization|protein phosphorylation|replicative cell aging|regulation of transcription from RNA polymerase II promoter	AMP-activated protein kinase activity|protein serine/threonine kinase activator activity	AMP-activated protein kinase complex|plasma membrane|nucleus|nuclear envelope lumen|cytoplasm
YOL093W	YOL093W	TRM10	hom	Verified	1.53331872995782	0.0625986709614965	no	360	0.0774775703647515	329	NA	FT	RNA PROCESSING	NUCLEUS		tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress	tRNA methylation	tRNA (guanine) methyltransferase activity	nucleus|cytoplasm
YNL201C	YNL201C	PSY2	hom	Verified	1.53327437997287	0.0626041321949607	no	361	0.0759996429055041	314	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3	Unknown|response to DNA damage stimulus|protein dephosphorylation|signal transduction involved in meiotic recombination checkpoint	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus
YLR428C_d	YLR428C	YLR428C	hom	Dubious	1.52785632017905	0.0632741076130659	no	362	0.067621432035786	345	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1	Unknown	Unknown	Unknown
YJR087W_d	YJR087W	YJR087W	hom	Dubious	1.5252780177211	0.0635948841307169	no	363	0.0570816952791331	247	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2	Unknown	Unknown	Unknown
YKR066C	YKR066C	CCP1	hom	Verified	1.52498789935012	0.0636310579349295	no	364	0.064662313337315	302	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress	cellular response to oxidative stress	cytochrome-c peroxidase activity	mitochondrion|mitochondrial intermembrane space
YOR138C	YOR138C	RUP1	hom	Verified	1.51809997756946	0.0644945984173796	no	365	0.0737668049018638	304	NA	FT		NUCLEUS		Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress	protein deubiquitination	protein binding	nucleus|cytoplasm
YPL002C	YPL002C	SNF8	hom	Verified	1.51492482741434	0.064895721084073	no	366	0.0868318251206143	398	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression	negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	molecular_function	ESCRT II complex
YKL109W	YKL109W	HAP4	hom	Verified	1.50945894849699	0.0655907692382959	no	367	0.066829174555258	290	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex	regulation of cellular respiration|carbon catabolite activation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity	CCAAT-binding factor complex
YJL172W	YJL172W	CPS1	hom	Verified	1.50578613623	0.0660610417082447	no	368	0.0803817317273431	262	NA	FT	PROTEOLYSIS			Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions	nitrogen compound metabolic process|proteolysis involved in cellular protein catabolic process	carboxypeptidase activity	fungal-type vacuole lumen
YML129C	YML129C	COX14	hom	Verified	1.50201890400141	0.0665461133872752	no	369	0.0749098019361165	284	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes	mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation	molecular_function	mitochondrial envelope|mitochondrion|integral to membrane|mitochondrial inner membrane|mitochondrial matrix|extrinsic to membrane
YPL192C	YPL192C	PRM3	hom	Verified	1.50180834342831	0.0665733064684532	no	370	0.0503275598913244	250	NA	FT	MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body	karyogamy involved in conjugation with cellular fusion|nuclear membrane fusion involved in karyogamy	molecular_function	nuclear envelope|spindle pole body|extrinsic to nuclear outer membrane
YBR003W	YBR003W	COQ1	hom	Verified	1.50159831144265	0.0666004398526548	no	371	0.0785903624376398	343	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis	ubiquinone biosynthetic process	trans-hexaprenyltranstransferase activity	mitochondrion
YKL126W	YKL126W	YPK1	hom	Verified	1.50143802141182	0.0666211529854381	no	372	0.238863216440161	900	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication	eisosome assembly|protein autophosphorylation|negative regulation of phospholipid translocation|protein phosphorylation	protein serine/threonine kinase activity	cytosol|plasma membrane|cellular bud neck
YLR081W	YLR081W	GAL2	hom	Verified	1.49820230235701	0.0670403488251531	no	373	0.0567350913072092	261	NA	FT	CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Galactose permease, required for utilization of galactose; also able to transport glucose	galactose transport|galactose metabolic process	galactose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YHL009C	YHL009C	YAP3	hom	Verified	1.49652893587199	0.067257936625461	no	374	0.0716424518038489	312	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YML106W	YML106W	URA5	hom	Verified	1.4949247126603	0.0674670459441618	no	375	0.0634619483360468	268	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication	'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process	orotate phosphoribosyltransferase activity	nucleus|cytoplasm
YBR074W_p	YBR074W	YBR074W	hom	Uncharacterized	1.4947283787497	0.0674926723962597	no	376	0.0806012449651207	334	NA	FT	PROTEOLYSIS			Putative metalloprotease	biological_process	molecular_function	cellular_component
YMR169C	YMR169C	ALD3	hom	Verified	1.49187082392547	0.0678665063097307	no	377	0.068220707259059	305	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose	beta-alanine biosynthetic process|polyamine catabolic process	aldehyde dehydrogenase (NAD) activity	cytoplasm
YLR204W	YLR204W	QRI5	hom	Verified	1.4908332573149	0.0680026389246303	no	378	0.11633932844038	454	NA	FF|FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA	mRNA processing	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YBR292C_d	YBR292C	YBR292C	hom	Dubious	1.49044251621448	0.0680539602319471	no	379	0.0641135955066989	342	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene	Unknown	Unknown	Unknown
YDR194W-A_p	YDR194W-A	YDR194W-A	hom	Uncharacterized	1.48929840821784	0.0682044033570342	no	380	0.0847316281401113	328	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YPL072W	YPL072W	UBP16	hom	Verified	1.48602547991802	0.0686361907607339	no	381	0.055868344567167	257	NA	FT	PROTEOLYSIS	MITOCHONDRION		Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria	protein deubiquitination	ubiquitin-specific protease activity	mitochondrial outer membrane|cytoplasm
YLL047W_d	YLL047W	YLL047W	hom	Dubious	1.48509999997589	0.0687586680528124	no	382	0.0782093666807391	311	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1	Unknown	Unknown	Unknown
YJR032W	YJR032W	CPR7	hom	Verified	1.4850111857025	0.0687704305208055	no	383	0.0802867346472391	331	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity	protein refolding|response to stress	unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity	cytosol
YNL175C	YNL175C	NOP13	hom	Verified	1.48457873252544	0.0688277263309834	no	384	0.081502113071786	361	NA	FT		NUCLEUS		Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress	biological_process	RNA binding	nucleolus|preribosome
YDR452W	YDR452W	PPN1	hom	Verified	1.4825254442011	0.0691002692563477	no	385	0.100690989520183	237	NA	FT		NUCLEUS		Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress	polyphosphate catabolic process|polyphosphate metabolic process	endopolyphosphatase activity|exopolyphosphatase activity	fungal-type vacuole membrane|nucleus
YPR067W	YPR067W	ISA2	hom	Verified	1.48167272906118	0.0692136983813573	no	386	0.0957447940000788	403	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations	iron-sulfur cluster assembly|biotin biosynthetic process	iron ion binding	mitochondrion|mitochondrial intermembrane space
YMR225C	YMR225C	MRPL44	hom	Verified	1.47778829174764	0.0697322265947423	no	387	0.0658156167885636	315	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YMR294W-A_d	YMR294W-A	YMR294W-A	hom	Dubious	1.4749672911436	0.0701106686957391	no	388	0.0794890678787054	309	NA					Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents	Unknown	Unknown	Unknown
YDR003W-A_p	YDR003W-A	YDR003W-A	hom	Uncharacterized	1.47455890218443	0.0701655854473164	no	389	0.0852048879082152	326	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YFL012W_p	YFL012W	YFL012W	hom	Uncharacterized	1.47420710245924	0.0702129190711016	no	390	0.0893339808770211	364	NA					Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin	biological_process	molecular_function	cellular_component
YLR037C	YLR037C	PAU23	hom	Verified	1.47259027008993	0.0704307749931965	no	391	0.0711562010759349	322	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth	biological_process	molecular_function	fungal-type cell wall
YER155C	YER155C	BEM2	hom	Verified	1.47087194314556	0.0706628757966182	no	392	0.0764009968733296	304	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence	negative regulation of Rho protein signal transduction|fungal-type cell wall organization|establishment of cell polarity|actin cytoskeleton organization	Rho GTPase activator activity	cell cortex|incipient cellular bud site|mitochondrion|plasma membrane|mating projection tip|cytoplasm|cellular bud tip
YBR290W	YBR290W	BSD2	hom	Verified	1.47071747383683	0.0706837693018936	no	393	0.0761744626524918	364	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification	metal ion transport|ubiquitin-dependent protein catabolic process|protein targeting to vacuole	protein binding	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YLR454W_p	YLR454W	FMP27	hom	Uncharacterized	1.47055899844668	0.0707052096028076	no	394	0.0625120443058642	325	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YDL101C	YDL101C	DUN1	hom	Verified	1.47018114703081	0.0707563496778347	no	395	0.0828295789709735	392	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair	protein phosphorylation|replication fork protection|cell cycle checkpoint|DNA damage checkpoint	protein kinase activity	nucleus
YHR171W	YHR171W	ATG7	hom	Verified	1.46539673481843	0.0714063538860186	no	396	0.110708390381382	401	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	MITOCHONDRION		Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation	C-terminal protein lipidation|protein modification by small protein conjugation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway	APG8 activating enzyme activity|APG12 activating enzyme activity	cytosol|mitochondrion|membrane|pre-autophagosomal structure
YGL013C	YGL013C	PDR1	hom	Verified	1.46364335739493	0.0716457097209906	no	397	0.184437130436398	712	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RSC COMPLEX	Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication	Unknown|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDR371W_p	YDR371W	CTS2	hom	Uncharacterized	1.46090486142334	0.0720207761559378	no	398	0.0600042783020968	250	NA	FT	CARBOHYDRATE METABOLISM			Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect	sporulation resulting in formation of a cellular spore	molecular_function	cytoplasm
YBR201W	YBR201W	DER1	hom	Verified	1.45933637146118	0.0722362746892431	no	399	0.0726370096366205	328	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p	ER-associated protein catabolic process	molecular_function	integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YKL029C	YKL029C	MAE1	hom	Verified	1.45630001780897	0.0726548503118174	no	400	0.0645984498509097	333	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids	pyruvate metabolic process|cellular amino acid metabolic process	malic enzyme activity	mitochondrion
YIL071C	YIL071C	PCI8	hom	Verified	1.45221198557874	0.0732213355373328	no	401	0.0843865885164968	342	NA	FT		NUCLEUS		Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain	cullin deneddylation	molecular_function	signalosome
YBL005W	YBL005W	PDR3	hom	Verified	1.45022919201405	0.0734973085470022	no	402	0.0719946092001755	297	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YOR166C	YOR166C	SWT1	hom	Verified	1.44900499654892	0.0736680936091885	no	403	0.0570619175804681	253	NA	FT		NUCLEUS		RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain	nuclear mRNA surveillance of mRNP export|transcription, DNA-dependent	endoribonuclease activity	nucleus|cytoplasm
YHL037C_d	YHL037C	YHL037C	hom	Dubious	1.44296191368638	0.0745156002024288	no	404	0.0632625158759605	266	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER134C	YER134C	YER134C	hom	Verified	1.44289383445837	0.0745251901285671	no	405	0.0730004342227466	291	NA	FT		NUCLEUS		Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene	biological_process	acid phosphatase activity	nucleus|cytoplasm
YGL126W	YGL126W	SCS3	hom	Verified	1.44271616061666	0.0745502224502545	no	406	0.0820348187898321	327	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol	phospholipid metabolic process	molecular_function	integral to membrane|endoplasmic reticulum
YMR304C-A_d	YMR304C-A	YMR304C-A	hom	Dubious	1.43607459915595	0.0754905575318644	no	407	0.0690632180886591	286	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10	Unknown	Unknown	Unknown
YKR082W	YKR082W	NUP133	hom	Verified	1.43273324791699	0.0759670420432167	no	408	0.080513115836342	358	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133	poly(A)+ mRNA export from nucleus|double-strand break repair|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|tRNA export from nucleus|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore outer ring
YKR073C_d	YKR073C	YKR073C	hom	Dubious	1.43011033354639	0.0763426774197913	no	409	0.0975768780356424	446	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR213W	YBR213W	MET8	hom	Verified	1.42849697624283	0.076574432164927	no	410	0.0890949137639227	354	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis	siroheme biosynthetic process|sulfate assimilation	precorrin-2 dehydrogenase activity|ferrochelatase activity	cellular_component
YFR034C	YFR034C	PHO4	hom	Verified	1.4262864250003	0.076892840725216	no	411	0.110087559329441	460	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability	cellular response to phosphate starvation|positive regulation of phosphate metabolic process|phosphate-containing compound metabolic process|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YOL113W	YOL113W	SKM1	hom	Verified	1.42618390542538	0.076907632064844	no	412	0.0883454149923034	388	NA	FT	CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS|PLASMA MEMBRANE		Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth	negative regulation of gene expression|cytokinetic cell separation|protein phosphorylation|sterol import	protein serine/threonine kinase activity|protein kinase activity	plasma membrane|nucleus
YJL089W	YJL089W	SIP4	hom	Verified	1.42548083132316	0.077009128615227	no	413	0.0840769051134696	359	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YBR277C_d	YBR277C	YBR277C	hom	Dubious	1.42396945229763	0.0772276575597422	no	414	0.0795065376921036	370	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W	Unknown	Unknown	Unknown
YLR143W	YLR143W	DPH6	hom	Verified	1.42350335666427	0.0772951448735245	no	415	0.103005346047389	371	NA					Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene	biological_process	molecular_function	cytoplasm
YPR076W_d	YPR076W	YPR076W	hom	Dubious	1.42249222384093	0.077441703677976	no	416	0.0899277887342523	367	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR269W	YMR269W	TMA23	hom	Verified	1.42238443075425	0.077457340204095	no	417	0.0774660953304037	346	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan	ribosomal small subunit biogenesis	molecular_function	ribosome|nucleolus
YPL213W	YPL213W	LEA1	hom	Verified	1.42191321137017	0.07752572370706	no	418	0.0752299811568667	371	NA	FT	RNA PROCESSING	NUCLEUS		Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein	mRNA splicing, via spliceosome	molecular_function	U2 snRNP|U2-type prespliceosome|cytoplasm
YOL030W	YOL030W	GAS5	hom	Verified	1.41971766332786	0.0778449468576426	no	419	0.0743489769151072	313	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall	(1->3)-beta-D-glucan metabolic process	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane
YMR080C	YMR080C	NAM7	hom	Verified	1.41769015975633	0.0781406221282852	no	420	0.094867372606141	310	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RNA LOCALIZATION|GENE SILENCING	NUCLEUS		ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|intracellular mRNA localization|translational frameshifting|regulation of translational termination|chromatin silencing at silent mating-type cassette|protein ubiquitination	RNA-dependent ATPase activity|ATP-dependent RNA helicase activity|nucleic acid binding	mitochondrion|polysome|cytoplasm
YCR063W	YCR063W	BUD31	hom	Verified	1.41178193457375	0.0790070896615354	no	421	0.0641014001078309	324	NA	FT	CELL CYCLE|RNA PROCESSING|CELL DIVISION	NUCLEUS		Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis	RNA splicing|mRNA splicing, via spliceosome|cellular bud site selection	molecular_function	U2 snRNP|nucleus
YKL086W	YKL086W	SRX1	hom	Verified	1.41155129673689	0.0790410607161291	no	422	0.070918017382526	290	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress	sulfiredoxin activity	nucleus|cytoplasm
YPL154C	YPL154C	PEP4	hom	Verified	1.40997372697723	0.0792737204350186	no	423	0.0905259369195902	390	NA	FT	MEMBRANE ORGANIZATION|PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS	MITOCHONDRION		Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates	microautophagy|proteolysis involved in cellular protein catabolic process|cellular response to starvation	peptidase activity	fungal-type vacuole lumen|mitochondrion|fungal-type vacuole
YER004W	YER004W	FMP52	hom	Verified	1.40886464270475	0.0794375981111265	no	424	0.091696561638223	325	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YIL027C	YIL027C	EMC5	hom	Verified	1.40793937618272	0.0795745110470655	no	425	0.0988136746080293	403	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YML007C-A_p	YML007C-A	YML007C-A	hom	Uncharacterized	1.40603115364371	0.0798574370323933	no	426	0.100834206172357	486	NA	FF|FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria	biological_process	molecular_function	mitochondrion
YPL070W	YPL070W	MUK1	hom	Verified	1.40549509501068	0.0799370534276885	no	427	0.0681722761299461	286	NA					Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation	biological_process	molecular_function	cytoplasm
YNL107W	YNL107W	YAF9	hom	Verified	1.4036953192211	0.0802047984517699	no	428	0.109919889640758	465	NA	FF|FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain	DNA repair|chromatin remodeling|histone exchange|chromatin silencing at telomere	molecular_function	Swr1 complex|nucleus|NuA4 histone acetyltransferase complex|cytoplasm
YGL027C	YGL027C	CWH41	hom	Verified	1.40361798136441	0.0802163188479351	no	429	0.102024394993104	371	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress	fungal-type cell wall biogenesis|protein N-linked glycosylation	mannosyl-oligosaccharide glucosidase activity	endoplasmic reticulum membrane
YBL022C	YBL022C	PIM1	hom	Verified	1.40141972944526	0.0805442979302505	no	430	0.119897321031284	462	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria	chaperone-mediated protein complex assembly|misfolded or incompletely synthesized protein catabolic process	ATP-dependent peptidase activity	mitochondrion|mitochondrial matrix
YPL101W	YPL101W	ELP4	hom	Verified	1.40085297393512	0.0806290218488151	no	431	0.108273321387908	423	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex|cytoplasm
YJR097W	YJR097W	JJJ3	hom	Verified	1.3938806204526	0.0816768286722694	no	432	0.0905722654530458	383	NA	FT		NUCLEUS		Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	ferrous iron binding	nucleus|cytoplasm
YNL292W	YNL292W	PUS4	hom	Verified	1.39357407919885	0.0817231302413633	no	433	0.0857080917065479	366	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)	tRNA modification	pseudouridine synthase activity	mitochondrion|nucleus
YHR134W	YHR134W	WSS1	hom	Verified	1.39239189781314	0.0819018783072356	no	434	0.0526327773680665	294	NA	FT	RESPONSE TO DNA DAMAGE	ENDOMEMBRANE SYSTEM|NUCLEUS		Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response	protein sumoylation|response to UV-B|response to UV-C|response to DNA damage stimulus	molecular_function	nuclear envelope
YBR159W	YBR159W	IFA38	hom	Verified	1.39239178744367	0.0819018950090519	no	435	0.0819999877697618	347	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides	fatty acid elongation	ketoreductase activity	integral to membrane|endoplasmic reticulum
YGL101W_p	YGL101W	YGL101W	hom	Uncharacterized	1.38714155667132	0.0826993011582502	no	436	0.085580787434754	274	NA	FT		NUCLEUS		Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p	biological_process	molecular_function	nucleus|cytoplasm
YBR039W	YBR039W	ATP3	hom	Verified	1.38672924188923	0.0827621701876629	no	437	0.104206997952977	427	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	ATP synthesis coupled proton transport	proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YIL009C-A	YIL009C-A	EST3	hom	Verified	1.38507380558068	0.0830149502871506	no	438	0.093049873297628	351	NA	FT		NUCLEUS|CHROMOSOME		Component of the telomerase holoenzyme, involved in telomere replication	telomere maintenance via telomerase	ATP-dependent DNA/RNA helicase activity|GTPase activity|telomeric DNA binding	chromosome, telomeric region|nucleus|telomerase holoenzyme complex
YMR053C	YMR053C	STB2	hom	Verified	1.38450452343557	0.0831020119935926	no	439	0.0746419420335825	358	NA	FT		NUCLEUS|CHROMOSOME		Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p	biological_process	molecular_function	Sin3-type complex
YOL036W_p	YOL036W	YOL036W	hom	Uncharacterized	1.38435599086359	0.0831247387328777	no	440	0.0808815192932072	351	NA					Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YNL100W	YNL100W	AIM37	hom	Verified	1.37966607324951	0.0838447417117825	no	441	0.0937286325033144	404	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YKL023W_p	YKL023W	YKL023W	hom	Uncharacterized	1.37922968797024	0.0839119736743237	no	442	0.0755200067567601	367	NA					Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YML055W	YML055W	SPC2	hom	Verified	1.37792131858453	0.0841137910522943	no	443	0.10269791887349	405	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25	signal peptide processing|protein targeting to ER	peptidase activity	signal peptidase complex
YHR191C	YHR191C	CTF8	hom	Verified	1.37772879791334	0.0841435182999098	no	444	0.115822725944838	430	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion	maintenance of DNA trinucleotide repeats|mitotic sister chromatid cohesion	molecular_function	Ctf18 RFC-like complex
YBL070C_d	YBL070C	YBL070C	hom	Dubious	1.37763430992372	0.0841581111394745	no	445	0.0919803122336877	329	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR052W	YMR052W	FAR3	hom	Verified	1.37624233632784	0.0843733094200831	no	446	0.100028545975437	438	NA	FT	CELL CYCLE|SIGNALING	ENDOPLASMIC RETICULUM		Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	endoplasmic reticulum
YDR447C	YDR447C	RPS17B	hom	Verified	1.37388549282982	0.084738617039044	no	447	0.0880889269111785	344	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit
YOR130C	YOR130C	ORT1	hom	Verified	1.37220721155382	0.0849994705337554	no	448	0.0678444529108623	319	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome	arginine biosynthetic process|mitochondrial ornithine transport	L-ornithine transmembrane transporter activity	mitochondrial envelope|integral to membrane
YHR183W	YHR183W	GND1	hom	Verified	1.36987130806868	0.0853635387901548	no	449	0.0861034288830919	376	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication	cellular response to oxidative stress|pentose-phosphate shunt, oxidative branch	phosphogluconate dehydrogenase (decarboxylating) activity	mitochondrion|cytoplasm
YOL087C	YOL087C	DUF1	hom	Verified	1.36845581822051	0.0855847212654971	no	450	0.144513380705195	511	NA					Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid	biological_process	ubiquitin binding	cytoplasm
YMR267W	YMR267W	PPA2	hom	Verified	1.36689634189497	0.0858288993906708	no	451	0.11429934196884	481	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate	aerobic respiration	inorganic diphosphatase activity	mitochondrion
YGL215W	YGL215W	CLG1	hom	Verified	1.36404173267719	0.08627721575372	no	452	0.100445515991877	363	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS			Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2	positive regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YDR409W	YDR409W	SIZ1	hom	Verified	1.3636109501576	0.0863450219578096	no	453	0.0874766961610255	344	NA	FT	CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON		SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring	protein sumoylation|chromosome segregation	SUMO ligase activity	nuclear chromatin|septin ring
YKR050W	YKR050W	TRK2	hom	Verified	1.3592279290975	0.0870371868494917	no	454	0.0975356193168048	315	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication	cellular potassium ion homeostasis	potassium ion transmembrane transporter activity	integral to membrane|plasma membrane
YDR271C_d	YDR271C	YDR271C	hom	Dubious	1.35905252268735	0.0870649729528426	no	455	0.120922142070338	468	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W	Unknown	Unknown	Unknown
YHR049W	YHR049W	FSH1	hom	Verified	1.35851945782762	0.0871494563387001	no	456	0.0620075461697522	293	NA	FT		NUCLEUS		Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2	biological_process	hydrolase activity	nucleus|cytoplasm
YAL042C-A_d	YAL042C-A	YAL042C-A	hom	Dubious	1.35833293026908	0.087179032823136	no	457	0.0875892180774416	337	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene	Unknown	Unknown	Unknown
YNL271C	YNL271C	BNI1	hom	Verified	1.35829322649505	0.0871853293645711	no	458	0.13628894777988	557	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1	barbed-end actin filament capping|actin nucleation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly|establishment of mitotic spindle orientation|formin-nucleated actin cable assembly	profilin binding	incipient cellular bud site|actin filament|polarisome|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YOR112W	YOR112W	CEX1	hom	Verified	1.35552164845896	0.0876257080318198	no	459	0.0887419110418001	362	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p	tRNA export from nucleus	tRNA binding	nuclear pore|cytoplasm
YAR023C_p	YAR023C	YAR023C	hom	Uncharacterized	1.35513182587692	0.0876877802122043	no	460	0.0861910687550772	355	NA					Putative integral membrane protein, member of DUP240 gene family	biological_process	molecular_function	cellular_component
YDR219C	YDR219C	MFB1	hom	Verified	1.35306874832072	0.0880168342306603	no	461	0.0684702390096808	286	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|mitochondrion organization	molecular_function	extrinsic to mitochondrial outer membrane|SCF ubiquitin ligase complex
YGR043C	YGR043C	NQM1	hom	Verified	1.35165593660831	0.0882427035735081	no	462	0.0803074180316886	312	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift	biological_process	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	nucleus
YKR060W	YKR060W	UTP30	hom	Verified	1.34713475937294	0.0889684175406688	no	463	0.101450441822266	299	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS		Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit	ribosomal small subunit biogenesis	molecular_function	nucleolus|nucleus|90S preribosome
YMR264W	YMR264W	CUE1	hom	Verified	1.34390203885141	0.0894900333226102	no	464	0.109596250189021	473	NA	FF|FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication	ER-associated protein catabolic process|establishment of protein localization to endoplasmic reticulum membrane	ubiquitin-protein ligase activator activity	Doa10p ubiquitin ligase complex|mitochondrion|integral to endoplasmic reticulum membrane
YDL137W	YDL137W	ARF2	hom	Verified	1.34227446652659	0.0897535096014565	no	465	0.0953718490254906	388	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport	GTPase activity	cytosol|Golgi-associated vesicle
YDL112W	YDL112W	TRM3	hom	Verified	1.34013854592305	0.090100153214783	no	466	0.100784480900177	365	NA	FT	RNA PROCESSING			2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs	tRNA methylation	tRNA (guanine) methyltransferase activity	cytoplasm
YDR011W	YDR011W	SNQ2	hom	Verified	1.34008589466558	0.0901087106558718	no	467	0.129051832107067	507	NA	FF|FT	NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species	response to drug	xenobiotic-transporting ATPase activity	mitochondrion|integral to membrane|plasma membrane
YBR176W	YBR176W	ECM31	hom	Verified	1.33897477416065	0.0902894426065818	no	468	0.0958497662215467	276	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate	pantothenate biosynthetic process	3-methyl-2-oxobutanoate hydroxymethyltransferase activity	mitochondrion
YER060W	YER060W	FCY21	hom	Verified	1.33856946770029	0.090355435664243	no	469	0.080067265093304	324	NA					Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function	transmembrane transport	nucleobase transmembrane transporter activity	integral to membrane
YLR134W	YLR134W	PDC5	hom	Verified	1.33699080961079	0.0906128183826389	no	470	0.0841377877026232	331	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism	L-phenylalanine catabolic process|glucose catabolic process to ethanol|pyruvate metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	pyruvate decarboxylase activity	nucleus|cytoplasm
YGR281W	YGR281W	YOR1	hom	Verified	1.33294593830883	0.0912747728231995	no	471	0.106644434672567	421	NA	FT	NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR)	transport|response to drug	xenobiotic-transporting ATPase activity	integral to membrane|plasma membrane
YOR096W	YOR096W	RPS7A	hom	Verified	1.33222952333035	0.0913923889349977	no	472	0.123199337922864	436	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication	cytoplasmic translation|ribosome biogenesis	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YEL064C	YEL064C	AVT2	hom	Verified	1.33026266938569	0.0917158711286191	no	473	0.0669511616302756	287	NA	FT		ENDOPLASMIC RETICULUM		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	transport	transporter activity	integral to membrane|endoplasmic reticulum
YKL068W-A_p	YKL068W-A	YKL068W-A	hom	Uncharacterized	1.32940440866905	0.0918572920623222	no	474	0.134763142569542	483	NA					Putative protein of unknown function; identified by homology to <i>Ashbya gossypii</i>	biological_process	molecular_function	cellular_component
YIL090W	YIL090W	ICE2	hom	Verified	1.32677242265387	0.0922919877624696	no	475	0.101627825344703	366	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells	endoplasmic reticulum inheritance	molecular_function	integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum
YNL083W	YNL083W	SAL1	hom	Verified	1.32571218526932	0.0924675248398405	no	476	0.0847472577335576	313	NA	FT		MITOCHONDRION		ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains	ATP transport|ADP transport|mitochondrial transport	ATP:ADP antiporter activity|calcium ion binding	mitochondrion|integral to membrane|mitochondrial inner membrane
YCL051W	YCL051W	LRE1	hom	Verified	1.32471430475759	0.0926329634130725	no	477	0.105767935116969	451	NA	FT	CELL WALL ORG/BIOGENESIS			Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; <br>LRE1 has a paralog, HLR1, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cellular_component
YLR258W	YLR258W	GSY2	hom	Verified	1.32274535871699	0.0929600369170329	no	478	0.0965930080759727	389	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress	glycogen biosynthetic process	glycogen (starch) synthase activity	cytoplasm
YLR435W	YLR435W	TSR2	hom	Verified	1.32176014393992	0.0931240170029395	no	479	0.0919230487274303	392	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein with a potential role in pre-rRNA processing	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleus|cytoplasm
YGL124C	YGL124C	MON1	hom	Verified	1.31779023171115	0.0937869394068767	no	480	0.108975338913615	422	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate	autophagy|vesicle docking|protein targeting to vacuole	molecular_function	cytosol|fungal-type vacuole membrane|Mon1-Ccz1 complex
YPL141C	YPL141C	FRK1	hom	Verified	1.31744391083882	0.0938449351619339	no	481	0.0916768602822493	406	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication	protein phosphorylation	protein kinase activity	cytoplasm
YGR273C_p	YGR273C	YGR273C	hom	Uncharacterized	1.31743325779292	0.0938467195670763	no	482	0.100674775825609	414	NA					Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene	biological_process	molecular_function	cellular_component
YOR265W	YOR265W	RBL2	hom	Verified	1.31652604956145	0.093998770537187	no	483	0.110245456508318	418	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress	tubulin complex assembly|tubulin complex biogenesis	tubulin binding|beta-tubulin binding	cytoplasm
YPL013C	YPL013C	MRPS16	hom	Verified	1.31613333653959	0.0940646468319781	no	484	0.112507078061031	388	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YDL109C_p	YDL109C	YDL109C	hom	Uncharacterized	1.31559416956321	0.0941551457666903	no	485	0.102397004478204	446	NA	FT	LIPID METABOLISM			Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication	cellular lipid metabolic process	molecular_function	cellular_component
YHR141C	YHR141C	RPL42B	hom	Verified	1.31062811115562	0.0949917185324927	no	486	0.117495280928428	398	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR109C	YGR109C	CLB6	hom	Verified	1.31052878367907	0.0950085067242691	no	487	0.0859121431519549	335	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1	regulation of cyclin-dependent protein kinase activity|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|premeiotic DNA replication	cyclin-dependent protein kinase regulator activity	cellular_component
YMR276W	YMR276W	DSK2	hom	Verified	1.30762244507488	0.0955007000571092	no	488	0.0877824935450064	331	NA	FT	CELL CYCLE|PROTEOLYSIS|CYTOSKELETON ORGANIZATION	NUCLEUS		Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process|spindle pole body duplication associated with nuclear envelope	protein binding, bridging	nucleus
YDR326C	YDR326C	YSP2	hom	Verified	1.30731787577442	0.0955523878173827	no	489	0.101603817116595	439	NA	FT		MITOCHONDRION		Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication	apoptotic process	molecular_function	mitochondrion
YDL090C	YDL090C	RAM1	hom	Verified	1.3066153575291	0.0956716890887215	no	490	0.163042397437364	605	NA	FF|FT	PROTEIN PRENYLATION			Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit	protein farnesylation	protein farnesyltransferase activity	protein farnesyltransferase complex
YPR083W	YPR083W	MDM36	hom	Verified	1.30618839357423	0.095744249402977	no	491	0.0998659661068124	363	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission	mitochondrial fission|mitochondrion organization	molecular_function	mitochondrion|cytoplasm
YDR316W	YDR316W	OMS1	hom	Verified	1.30452650215876	0.0960270647368253	no	492	0.120307703457195	471	NA	FT		MITOCHONDRION		Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations	biological_process	S-adenosylmethionine-dependent methyltransferase activity	mitochondrial envelope|mitochondrion
YLR039C	YLR039C	RIC1	hom	Verified	1.30374778339465	0.0961597957469423	no	493	0.19874108084677	649	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes	intracellular protein transport|retrograde transport, endosome to Golgi	guanyl-nucleotide exchange factor activity	nucleus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YOR178C	YOR178C	GAC1	hom	Verified	1.30133685530881	0.0965715885999186	no	494	0.0986943169392821	356	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock	meiosis|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|response to heat|mitotic cell cycle spindle assembly checkpoint	protein phosphatase type 1 regulator activity|structural molecule activity|heat shock protein binding	protein phosphatase type 1 complex
YPL110C	YPL110C	GDE1	hom	Verified	1.29325467074838	0.0979614963521799	no	495	0.098912366244541	376	NA	FT	LIPID METABOLISM|SIGNALING|CARBOHYDRATE METABOLISM			Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes	glycerophospholipid catabolic process	glycerophosphocholine phosphodiesterase activity	ribosome|cytoplasm
YDR391C_p	YDR391C	YDR391C	hom	Uncharacterized	1.29307839747001	0.0979919728899467	no	496	0.0963408201565191	348	NA	FT		NUCLEUS		Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YMR022W	YMR022W	UBC7	hom	Verified	1.29297650076153	0.0980095933567549	no	497	0.118791382105484	402	NA	FT	CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly	fungal-type cell wall organization|chromatin assembly or disassembly|ER-associated protein catabolic process	ubiquitin-protein ligase activity	endoplasmic reticulum membrane
YJR003C_p	YJR003C	YJR003C	hom	Uncharacterized	1.29181292360854	0.098210969345254	no	498	0.0997935721877576	368	NA	FT		MITOCHONDRION		Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	mitochondrion
YJR125C	YJR125C	ENT3	hom	Verified	1.29138065422999	0.0982858577669278	no	499	0.0986787943098685	367	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|CYTOSKELETON		Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p	late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|actin filament organization|endocytosis|actin cortical patch assembly|Golgi to endosome transport	protein binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding	clathrin vesicle coat|actin cortical patch
YNL093W	YNL093W	YPT53	hom	Verified	1.2881317566743	0.0988500512388431	no	500	0.132483703376337	503	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication	endocytosis|protein targeting to vacuole	GTPase activity	late endosome
YDL146W	YDL146W	LDB17	hom	Verified	1.28646684078977	0.099140092061767	no	501	0.0771473325119338	301	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck	endocytosis	molecular_function	cellular bud|cellular bud neck|cytoplasm|actin cortical patch
YGL251C	YGL251C	HFM1	hom	Verified	1.28625116184586	0.099177710437941	no	502	0.120970747815864	443	NA	FT	CELL CYCLE	NUCLEUS		Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity	meiosis|synapsis|DNA unwinding involved in replication|reciprocal meiotic recombination	DNA helicase activity	nucleus
YGR049W	YGR049W	SCM4	hom	Verified	1.28586633179855	0.0992448578056461	no	503	0.1067901072704	334	NA	FT		MITOCHONDRION		Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to membrane
YGL203C	YGL203C	KEX1	hom	Verified	1.28172740438868	0.099969144053105	no	504	0.0970843697220324	366	NA	FT	PROTEOLYSIS	GOLGI APPARATUS		Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins	protein processing	serine-type carboxypeptidase activity	trans-Golgi network
YER015W	YER015W	FAA2	hom	Verified	1.27978299138516	0.100310733661833	no	505	0.101700521923478	424	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome	long-chain fatty acid metabolic process	long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|medium-chain fatty acid-CoA ligase activity	mitochondrion|peroxisome
YJL099W	YJL099W	CHS6	hom	Verified	1.27967561517267	0.100329622035722	no	506	0.120958879982691	466	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication	Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process	molecular_function	trans-Golgi network transport vesicle|clathrin-coated vesicle|exomer complex
YLR062C_d	YLR062C	BUD28	hom	Dubious	1.279632841659	0.100337146977444	no	507	0.119632719585181	399	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YLR031W_p	YLR031W	YLR031W	hom	Uncharacterized	1.27961904250687	0.100339574684811	no	508	0.11210902599092	422	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR328W	YLR328W	NMA1	hom	Verified	1.27848364672273	0.100539473618547	no	509	0.130591214572593	355	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication	NAD biosynthetic process	nicotinamide-nucleotide adenylyltransferase activity	nucleus|cytoplasm
YHR189W	YHR189W	PTH1	hom	Verified	1.27568307100354	0.101033787651407	no	510	0.0953690494945257	398	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium	mitochondrial translation	aminoacyl-tRNA hydrolase activity	mitochondrion
YGR256W	YGR256W	GND2	hom	Verified	1.27536813084582	0.101089486603613	no	511	0.0870210766124762	379	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	phosphogluconate dehydrogenase (decarboxylating) activity	cytosol|plasma membrane
YLR429W	YLR429W	CRN1	hom	Verified	1.27360673877786	0.101401411411954	no	512	0.0819311270732029	371	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly	microtubule-based process|actin filament organization|actin cortical patch localization|Unknown|negative regulation of Arp2/3 complex-mediated actin nucleation	microtubule binding|actin filament binding|protein binding, bridging	Arp2/3 protein complex|actin cortical patch
YLR237W	YLR237W	THI7	hom	Verified	1.27337315017366	0.101442830200819	no	513	0.124952623935181	381	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia	thiamine transport	thiamine transmembrane transporter activity	integral to membrane|plasma membrane
YLR032W	YLR032W	RAD5	hom	Verified	1.27242093572217	0.101611799717309	no	514	0.111968320207253	465	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress	double-strand break repair|postreplication repair|protein polyubiquitination|free ubiquitin chain polymerization	four-way junction helicase activity|four-way junction DNA binding|DNA-dependent ATPase activity|Y-form DNA binding	nuclear chromatin
YPR043W	YPR043W	RPL43A	hom	Verified	1.27216813104271	0.101656694067291	no	515	0.0714098878700107	303	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YNL211C_p	YNL211C	YNL211C	hom	Uncharacterized	1.27134188079899	0.10180352455447	no	516	0.0959406311786694	376	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene	biological_process	molecular_function	mitochondrion
YER107C	YER107C	GLE2	hom	Verified	1.270192201559	0.102008087417083	no	517	0.156428998269272	596	NA	FF|FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1	poly(A)+ mRNA export from nucleus|Unknown|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear pore distribution|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	molecular_function	integral to membrane|nuclear pore|cytoplasm
YIR017C	YIR017C	MET28	hom	Verified	1.26984158152645	0.102070532851514	no	518	0.130287463702934	433	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism	regulation of transcription from RNA polymerase II promoter|regulation of sulfur amino acid metabolic process|Unknown	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YPR158W	YPR158W	CUR1	hom	Verified	1.26982166849046	0.10207408019809	no	519	0.116302055610641	466	NA	FT		NUCLEUS		Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication	cellular response to stress|protein localization to nucleus	chaperone binding	nucleus
YJR079W_p	YJR079W	YJR079W	hom	Uncharacterized	1.26955318859269	0.102121916481947	no	520	0.116599703520724	387	NA					Putative protein of unknown function; mutation results in impaired mitochondrial respiration	biological_process	molecular_function	cellular_component
YOL108C	YOL108C	INO4	hom	Verified	1.26795878780477	0.10240633417722	no	521	0.108987205354554	434	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain	phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YLR376C	YLR376C	PSY3	hom	Verified	1.26539211727142	0.102865399771767	no	522	0.101209256337182	433	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C	recombinational repair|error-free translesion synthesis	molecular_function	nucleus|Shu complex|cytoplasm
YKR045C_p	YKR045C	YKR045C	hom	Uncharacterized	1.26068440719719	0.103711287020945	no	523	0.104064040751822	414	NA					Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YPL001W	YPL001W	HAT1	hom	Verified	1.26055221074931	0.103735112874252	no	524	0.119702315445083	415	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair	histone acetylation|chromatin silencing at telomere	histone acetyltransferase activity|histone binding	histone acetyltransferase complex|nucleus|cytoplasm
YBR163W	YBR163W	EXO5	hom	Verified	1.26032386547615	0.10377627704696	no	525	0.112705584315061	486	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2	mitochondrial genome maintenance	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity	mitochondrion
YIL006W	YIL006W	YIA6	hom	Verified	1.26004622739783	0.103826343274612	no	526	0.113901788051262	407	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs	transport|mitochondrial pyruvate transport|NAD transmembrane transport	pyruvate secondary active transmembrane transporter activity|transporter activity|NAD transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YKR057W	YKR057W	RPS21A	hom	Verified	1.25955272081005	0.103915380124093	no	527	0.109979646082917	417	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YML060W	YML060W	OGG1	hom	Verified	1.25750042340142	0.104286242906215	no	528	0.100809231024569	377	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance	DNA repair|base-excision repair, AP site formation	oxidized purine nucleobase lesion DNA N-glycosylase activity	mitochondrion
YKR005C_p	YKR005C	YKR005C	hom	Uncharacterized	1.25534222428777	0.10467727659499	no	529	0.0969090921073247	407	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR077C	YBR077C	SLM4	hom	Verified	1.255127176089	0.104716298243221	no	530	0.133033471900143	469	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|SIGNALING			Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4	signal transduction|microautophagy	phosphatidylinositol-3,4-bisphosphate binding	fungal-type vacuole membrane|EGO complex|late endosome membrane|cytoplasm
YOL052C	YOL052C	SPE2	hom	Verified	1.25387266827393	0.104944145407587	no	531	0.118324157026521	371	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically	spermidine biosynthetic process|spermine biosynthetic process|pantothenate biosynthetic process	adenosylmethionine decarboxylase activity	nucleus|cytoplasm
YOR200W_d	YOR200W	YOR200W	hom	Dubious	1.25041111486172	0.105574703206252	no	532	0.156581225681219	576	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c	Unknown	Unknown	Unknown
YJR107W_p	YJR107W	YJR107W	hom	Uncharacterized	1.24760554149384	0.1060877740614	no	533	0.0980418311012091	357	NA	FT	LIPID METABOLISM			Putative lipase	biological_process	lipase activity	cellular_component
YPR071W_p	YPR071W	YPR071W	hom	Uncharacterized	1.24736447627742	0.106131942900773	no	534	0.111668777451971	428	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C	biological_process	molecular_function	integral to membrane
YOR273C	YOR273C	TPO4	hom	Verified	1.24587760090665	0.106404667268008	no	535	0.159203723031411	583	NA	FF|FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane	spermidine transport|spermine transport	spermidine transmembrane transporter activity|spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YMR062C	YMR062C	ARG7	hom	Verified	1.24382524425054	0.10678194365141	no	536	0.140916840130128	520	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine	fungal-type cell wall organization|ornithine biosynthetic process|arginine biosynthetic process	acetyl-CoA:L-glutamate N-acetyltransferase activity|glutamate N-acetyltransferase activity	mitochondrion|mitochondrial matrix
YCL032W	YCL032W	STE50	hom	Verified	1.24021272549775	0.107448361387942	no	537	0.118952639405304	451	NA	FT	CELL CYCLE|SIGNALING			Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction	pheromone-dependent signal transduction involved in conjugation with cellular fusion|MAPK cascade involved in osmosensory signaling pathway|osmosensory signaling pathway via Sho1 osmosensor|signal transduction involved in filamentous growth|cellular response to heat	SAM domain binding|protein kinase regulator activity	cytoplasm
YBR164C	YBR164C	ARL1	hom	Verified	1.23998203111551	0.107491020228248	no	538	0.180734075258059	687	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|VACUOLAR TRANSPORT	GOLGI APPARATUS		Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor	Golgi to plasma membrane protein transport|vesicle-mediated transport|protein targeting to vacuole	GTPase activity	trans-Golgi network|cytosol|Golgi apparatus
YDR495C	YDR495C	VPS3	hom	Verified	1.23961627229598	0.107558679517234	no	539	0.14126052511272	548	NA	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase	vacuole inheritance|vacuolar acidification|protein targeting to vacuole	molecular_function	CORVET complex|cytoplasm
YOL014W_p	YOL014W	YOL014W	hom	Uncharacterized	1.23938919395152	0.107600700666393	no	540	0.128768455459953	461	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YML013W	YML013W	UBX2	hom	Verified	1.23905371876596	0.107662802440152	no	541	0.157577539643738	625	NA	FF|FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis	proteasomal ubiquitin-dependent protein catabolic process|ER-associated protein catabolic process|lipid particle organization	protein binding, bridging	mitochondrial outer membrane|Doa10p ubiquitin ligase complex|integral to endoplasmic reticulum membrane|lipid particle|endoplasmic reticulum
YMR262W_p	YMR262W	YMR262W	hom	Uncharacterized	1.23849662869156	0.107765985681364	no	542	0.100657496563912	416	NA					Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene	biological_process	molecular_function	cellular_component
YOL068C	YOL068C	HST1	hom	Verified	1.23603418086956	0.108222929269506	no	543	0.118112870044123	459	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance	chromatin silencing|negative regulation of mitotic recombination|histone deacetylation	NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity	Set3 complex
YIL167W	YIL167W	SDL1	hom	pseudogene	1.23567208640369	0.108290238684242	no	544	0.109904009587534	425	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL167W and adjacent ORF, YIL168W, constitute a single ORF encoding L-serine dehydratase	serine family amino acid metabolic process	L-serine ammonia-lyase activity	cellular_component
YIR001C	YIR001C	SGN1	hom	Verified	1.23449621035508	0.108509028996385	no	545	0.104367686280756	372	NA					Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation	mRNA metabolic process	poly(A) RNA binding	cytoplasm
YLR050C_p	YLR050C	YLR050C	hom	Uncharacterized	1.23348516758569	0.108697403590258	no	546	0.105839537784903	403	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YPL030W	YPL030W	TRM44	hom	Verified	1.232477362929	0.108885408809706	no	547	0.0889946502662014	348	NA	FT	RNA PROCESSING			tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene	tRNA methylation	tRNA (uracil) methyltransferase activity	cytoplasm
YNL120C_d	YNL120C	YNL120C	hom	Dubious	1.23171514571415	0.109027755058772	no	548	0.0962617484162293	433	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene	Unknown	Unknown	Unknown
YDR203W_d	YDR203W	YDR203W	hom	Dubious	1.23041706716499	0.109270482709219	no	549	0.150008843492041	580	NA	FF				Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR182W-A_p	YDR182W-A	YDR182W-A	hom	Uncharacterized	1.22750385151984	0.109816637548906	no	550	0.1211657008736	423	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YLR094C	YLR094C	GIS3	hom	Verified	1.22548581490807	0.110196115732433	no	551	0.132401288205002	446	NA	FT	SIGNALING	NUCLEUS		Protein of unknown function	intracellular signal transduction	molecular_function	nucleus|cytoplasm
YCR087W_d	YCR087W	YCR087W	hom	Dubious	1.22238136484758	0.11078172150204	no	552	0.127683794817001	468	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene	Unknown	Unknown	Unknown
YIL070C	YIL070C	MAM33	hom	Verified	1.22121069401845	0.111003128128112	no	553	0.127783778236121	453	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R	aerobic respiration	molecular_function	mitochondrion|mitochondrial matrix
YDR382W	YDR382W	RPP2B	hom	Verified	1.22117139026539	0.111010567063147	no	554	0.0962151166044698	401	NA	FT	TRANSLATION		RIBOSOME	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	translational elongation|cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YPL254W	YPL254W	HFI1	hom	Verified	1.21783457657962	0.111643420953054	no	555	0.128256968881585	487	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions	histone acetylation|chromatin modification|transcription from RNA polymerase II promoter	transcription coactivator activity|transcription cofactor activity	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YJR154W_p	YJR154W	YJR154W	hom	Uncharacterized	1.21582251750176	0.112026269543178	no	556	0.101565672599401	389	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YNL323W	YNL323W	LEM3	hom	Verified	1.20980979218235	0.113175943944894	no	557	0.20770108569704	736	NA	FF|FT	MEMBRANE ORGANIZATION|SIGNALING	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane	phospholipid translocation|cell surface receptor signaling pathway	phospholipid-translocating ATPase activity	integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YIL073C	YIL073C	SPO22	hom	Verified	1.20690998697283	0.113733405566742	no	558	0.0925927574788396	401	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis	regulation of synaptonemal complex assembly	molecular_function	condensed nuclear chromosome
YGL100W	YGL100W	SEH1	hom	Verified	1.20637518628523	0.113836429614797	no	559	0.134620486680759	528	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE	NUCLEAR PORE	Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1	nucleocytoplasmic transport	structural constituent of nuclear pore	fungal-type vacuole membrane|integral to membrane|nuclear pore|Seh1-associated complex|nuclear pore outer ring
YML102W	YML102W	CAC2	hom	Verified	1.20542428875727	0.114019774812149	no	560	0.11655913446566	419	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription	DNA replication-dependent nucleosome assembly	histone binding	chromosome, centromeric region|CAF-1 complex
YLR345W_p	YLR345W	YLR345W	hom	Uncharacterized	1.20353327014641	0.114385012331284	no	561	0.116983775214167	438	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YIL008W	YIL008W	URM1	hom	Verified	1.20253439200293	0.114578274775299	no	562	0.122460878364565	483	NA	FT	RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response	cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|invasive growth in response to glucose limitation|tRNA wobble uridine modification	protein tag	cytosol|nucleus|cytoplasm
YDR535C_d	YDR535C	YDR535C	hom	Dubious	1.20153570597525	0.114771732265302	no	563	0.139336432401261	507	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.	Unknown	Unknown	Unknown
YOR354C	YOR354C	MSC6	hom	Verified	1.20142672238845	0.114792857751834	no	564	0.125223965622436	448	NA	FT	CELL CYCLE	MITOCHONDRION		Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	reciprocal meiotic recombination	molecular_function	mitochondrion
YBR250W	YBR250W	SPO23	hom	Verified	1.20101778350261	0.114872151535929	no	565	0.119734097285127	427	NA	FT	CELL CYCLE			Protein of unknown function; associates with meiosis-specific protein Spo1p	meiosis	molecular_function	cellular_component
YDR157W_d	YDR157W	YDR157W	hom	Dubious	1.19596669849406	0.115854777415465	no	566	0.112089031039038	385	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR104C	YJR104C	SOD1	hom	Verified	1.19339638493803	0.116357085059161	no	567	0.229176421843271	805	NA	FF|FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid	cellular copper ion homeostasis|fungal-type cell wall organization|superoxide metabolic process|cellular zinc ion homeostasis|positive regulation of sequence-specific DNA binding transcription factor activity|age-dependent response to reactive oxygen species involved in chronological cell aging	superoxide dismutase activity	cytosol|mitochondrion|nucleus|mitochondrial intermembrane space
YGR284C	YGR284C	ERV29	hom	Verified	1.19143405657603	0.116741614937189	no	568	0.122836331187858	458	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|ER to Golgi transport vesicle
YAL024C	YAL024C	LTE1	hom	Verified	1.18856917229378	0.117304622423995	no	569	0.17389238686524	624	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION			Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint|vesicle-mediated transport	guanyl-nucleotide exchange factor activity	cellular bud
YHR124W	YHR124W	NDT80	hom	Verified	1.18717385024932	0.117579526620426	no	570	0.110096124083625	448	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CHROMOSOME		Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)	meiosis|transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nuclear chromosome
YNL300W_p	YNL300W	TOS6	hom	Uncharacterized	1.18615737995566	0.117780076953262	no	571	0.137330706131642	525	NA					Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid	biological_process	molecular_function	fungal-type cell wall
YLR250W	YLR250W	SSP120	hom	Verified	1.1850131440579	0.118006125014543	no	572	0.116097108087652	401	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YPL056C_p	YPL056C	LCL1	hom	Uncharacterized	1.18352705656767	0.118300165001592	no	573	0.127849802705609	463	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan	biological_process	molecular_function	cellular_component
YAL056W	YAL056W	GPB2	hom	Verified	1.18173142193588	0.118656143152578	no	574	0.111922242667001	388	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	MITOCHONDRION|PLASMA MEMBRANE		Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication	signal transduction|glucose mediated signaling pathway|pseudohyphal growth|ascospore formation|negative regulation of Ras protein signal transduction|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter	cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding	mitochondrion|plasma membrane|cytoplasm
YPL227C	YPL227C	ALG5	hom	Verified	1.18074021376344	0.118852970518528	no	575	0.127960803819776	483	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum	protein N-linked glycosylation	dolichyl-phosphate beta-glucosyltransferase activity	endoplasmic reticulum membrane
YIL044C	YIL044C	AGE2	hom	Verified	1.18047638178105	0.118905399313447	no	576	0.122022523223652	463	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	GOLGI APPARATUS		ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport	ARF GTPase activator activity	clathrin-coated vesicle
YLR292C	YLR292C	SEC72	hom	Verified	1.17874110774024	0.119250640667379	no	577	0.140054823841046	498	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	posttranslational protein targeting to membrane, translocation	protein transporter activity	Sec62/Sec63 complex|endoplasmic reticulum membrane
YPL241C	YPL241C	CIN2	hom	Verified	1.17797213515177	0.119403857578313	no	578	0.120450218127899	520	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	CYTOSKELETON		GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2	protein folding|tubulin complex assembly|tubulin complex biogenesis	GTPase activator activity	cellular_component
YLL030C_d	YLL030C	RRT7	hom	Dubious	1.1771250167637	0.119572805685933	no	579	0.104316628932913	403	NA					Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL069C	YNL069C	RPL16B	hom	Verified	1.17680525478907	0.11963662238473	no	580	0.145864324016939	539	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YPL022W	YPL022W	RAD1	hom	Verified	1.17417685531925	0.120162097239859	no	581	0.119166859644097	441	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein	mitotic recombination|meiotic mismatch repair|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair via single-strand annealing, removal of nonhomologous ends|removal of nonhomologous ends	single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity	nucleotide-excision repair factor 1 complex|nucleus
YKR080W	YKR080W	MTD1	hom	Verified	1.17402609957611	0.120192285866721	no	582	0.130491424759229	445	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline	folic acid-containing compound biosynthetic process|one-carbon metabolic process|purine nucleobase biosynthetic process	methylenetetrahydrofolate dehydrogenase (NAD+) activity	cytosol
YNR030W	YNR030W	ALG12	hom	Verified	1.17228206031022	0.120541915843451	no	583	0.147100246326851	489	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation	dolichol-linked oligosaccharide biosynthetic process|protein glycosylation	alpha-1,6-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YGL248W	YGL248W	PDE1	hom	Verified	1.17208539325986	0.120581386847275	no	584	0.106504192869814	407	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation	cAMP-mediated signaling	3',5'-cyclic-AMP phosphodiesterase activity	cellular_component
YPL262W	YPL262W	FUM1	hom	Verified	1.17193766578122	0.12061104168195	no	585	0.119287421203301	467	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria	fumarate metabolic process|tricarboxylic acid cycle	fumarate hydratase activity	cytosol|mitochondrion|mitochondrial matrix
YLR421C	YLR421C	RPN13	hom	Verified	1.17075109466185	0.120849420403183	no	586	0.129709642739354	483	NA	FT	PROTEOLYSIS	NUCLEUS		Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress	ubiquitin-dependent protein catabolic process	ubiquitin binding	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YPL271W	YPL271W	ATP15	hom	Verified	1.16836792048313	0.121329194518287	no	587	0.151004691501774	474	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YDR424C	YDR424C	DYN2	hom	Verified	1.16835742124455	0.121331311155353	no	588	0.124126619299507	471	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex	microtubule-based process|actin filament-based process|nuclear pore complex assembly	molecular_function	cytoplasmic dynein complex|cytoplasmic microtubule|peroxisome|nuclear pore
YBR020W	YBR020W	GAL1	hom	Verified	1.16745366409108	0.121513605104544	no	589	0.11442306304643	439	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS			Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication	galactose catabolic process via UDP-galactose|carbohydrate phosphorylation|positive regulation of transcription by galactose	galactokinase activity	cytoplasm
YPR132W	YPR132W	RPS23B	hom	Verified	1.16732095764891	0.121540389096322	no	590	0.111776885429586	389	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity	structural constituent of ribosome	cytosolic small ribosomal subunit
YJR118C	YJR118C	ILM1	hom	Verified	1.16724732507923	0.121555252064828	no	591	0.161335540357607	591	NA	FF|FT	MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth	mitochondrial genome maintenance	molecular_function	integral to membrane|endoplasmic reticulum
YNL098C	YNL098C	RAS2	hom	Verified	1.16686084753557	0.121633284737033	no	592	0.169613861240349	571	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS	PLASMA MEMBRANE		GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes	pseudohyphal growth|ascospore formation|activation of adenylate cyclase activity|regulation of protein localization|replicative cell aging|positive regulation of transcription by galactose|Ras protein signal transduction	GTP binding|GTPase activity	plasma membrane
YGR200C	YGR200C	ELP2	hom	Verified	1.16681631330252	0.121642278789356	no	593	0.143305545012182	515	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin	regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YLR046C_p	YLR046C	YLR046C	hom	Uncharacterized	1.16678060214563	0.121649491286994	no	594	0.110507325202605	396	NA					Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	biological_process	molecular_function	integral to membrane
YGR036C	YGR036C	CAX4	hom	Verified	1.16673108920632	0.121659491795085	no	595	0.116757234726116	397	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation	lipid biosynthetic process|protein N-linked glycosylation	dolichyldiphosphatase activity	integral to endoplasmic reticulum membrane|integral to membrane
YGL184C	YGL184C	STR3	hom	Verified	1.16667269666986	0.121671286525947	no	596	0.129277684150884	477	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p	methionine biosynthetic process|transsulfuration	cystathionine beta-lyase activity	peroxisome
YDR266C	YDR266C	HEL2	hom	Verified	1.16606947964156	0.121793177593975	no	597	0.127122307855226	406	NA					RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor	biological_process	molecular_function	ribosome|cytoplasm
YDL129W	YDL129W	YDL129W	hom	Verified	1.16341298031074	0.122330992789947	no	598	0.0849457963384341	298	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YNL203C_d	YNL203C	YNL203C	hom	Dubious	1.16256903110483	0.122502200885174	no	599	0.127715243792537	516	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL177W_d	YGL177W	YGL177W	hom	Dubious	1.16140869693365	0.122737866932126	no	600	0.152055869123687	510	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER124C	YER124C	DSE1	hom	Verified	1.15959758689429	0.12310634196675	no	601	0.136077064533444	521	NA	FT	CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION	SITE OF POLARIZED GROWTH		Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress	cytokinesis, completion of separation|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|invasive growth in response to glucose limitation	molecular_function	cellular bud neck
YNL043C_d	YNL043C	YNL043C	hom	Dubious	1.15909704336698	0.123208315462555	no	602	0.127027950041774	466	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W	Unknown	Unknown	Unknown
YMR273C	YMR273C	ZDS1	hom	Verified	1.15764613576775	0.123504236808876	no	603	0.141408798670243	513	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL WALL ORG/BIOGENESIS|RNA LOCALIZATION|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|SITE OF POLARIZED GROWTH	NUCLEAR PORE	Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication	mRNA export from nucleus|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|chromatin silencing|establishment of cell polarity|regulation of protein localization|cell aging	protein phosphatase type 2A regulator activity	incipient cellular bud site|nuclear pore|cellular bud neck|cellular bud tip|cytoplasm
YLR417W	YLR417W	VPS36	hom	Verified	1.15128129931764	0.124808264015745	no	604	0.182722568455302	669	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome	negative regulation of transcription from RNA polymerase II promoter by glucose|protein retention in Golgi apparatus|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	ubiquitin binding	ESCRT II complex
YDR444W_p	YDR444W	YDR444W	hom	Uncharacterized	1.15120654100397	0.124823637444457	no	605	0.12723744014013	432	NA	FT	LIPID METABOLISM			Putative hydrolase acting on ester bonds	biological_process	molecular_function	cytoplasm
YNL233W	YNL233W	BNI4	hom	Verified	1.15062711172881	0.124942837153233	no	606	0.160099149111636	561	NA	FT	PROTEIN LOCALIZATION|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|CYTOSKELETON		Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p	asymmetric protein localization|barrier septum assembly|chitin biosynthetic process	protein binding	incipient cellular bud site|cellular bud neck septin collar|cellular bud neck|septin ring
YGL056C	YGL056C	SDS23	hom	Verified	1.15003112040408	0.125065526931933	no	607	0.127718186746052	483	NA	FT	CELL DIVISION	NUCLEUS		One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication	cytokinetic cell separation	molecular_function	nucleus|cytoplasm
YBR228W	YBR228W	SLX1	hom	Verified	1.1489620125024	0.125285822502428	no	608	0.135969258549679	502	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p	DNA-dependent DNA replication	5'-flap endonuclease activity	Slx1-Slx4 complex|nucleus
YNL214W	YNL214W	PEX17	hom	Verified	1.14890337628273	0.125297912650204	no	609	0.140771238159965	500	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis	protein import into peroxisome matrix, docking	protein binding	peroxisomal membrane
YLR012C_p	YLR012C	YLR012C	hom	Uncharacterized	1.1477339889878	0.125539197647832	no	610	0.160245047711194	560	NA					Putative protein of unknown function; YLR012C is not an essential gene	biological_process	molecular_function	cellular_component
YBR282W	YBR282W	MRPL27	hom	Verified	1.1467439690175	0.125743726276093	no	611	0.124118469171965	495	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOL131W_p	YOL131W	YOL131W	hom	Uncharacterized	1.14406732378828	0.126297858883549	no	612	0.12500108073421	487	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR199C	YHR199C	AIM46	hom	Verified	1.1426050821634	0.126601297262278	no	613	0.186791523921469	622	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YGL054C	YGL054C	ERV14	hom	Verified	1.14002979731147	0.127136943656119	no	614	0.259225444169753	924	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication	ascospore formation|ER to Golgi vesicle-mediated transport|axial cellular bud site selection	molecular_function	integral to membrane|ER to Golgi transport vesicle|endoplasmic reticulum membrane
YKL003C	YKL003C	MRP17	hom	Verified	1.13765404039686	0.12763248582069	no	615	0.136903682532847	477	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YMR177W	YMR177W	MMT1	hom	Verified	1.1339161768135	0.128414855388453	no	616	0.13080713388405	485	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p	cellular iron ion homeostasis	molecular_function	mitochondrion|integral to membrane
YNL286W	YNL286W	CUS2	hom	Verified	1.13227674674117	0.128759051520533	no	617	0.132243438469742	510	NA	FT	RNA PROCESSING	NUCLEUS		Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)	mRNA splicing, via spliceosome	RNA binding	U2 snRNP
YLR296W_d	YLR296W	YLR296W	hom	Dubious	1.1315168217932	0.128918813644565	no	618	0.127442535324946	482	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL035C	YDL035C	GPR1	hom	Verified	1.13070273966314	0.129090113928744	no	619	0.154970398171551	542	NA	FT	SIGNALING	PLASMA MEMBRANE		Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis	replicative cell aging|G-protein coupled receptor signaling pathway|sucrose mediated signaling|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|invasive growth in response to glucose limitation|detection of glucose|detection of sucrose stimulus	G-protein coupled receptor activity|glucose binding	integral to membrane|plasma membrane
YLR403W	YLR403W	SFP1	hom	Verified	1.13045973528552	0.129141277816108	no	620	0.122625256452241	488	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS	NUCLEUS		Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion	positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of cell size|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription factor binding transcription factor activity	nucleus|cytoplasm
YMR293C	YMR293C	HER2	hom	Verified	1.12782835588905	0.129696207761527	no	621	0.146732685218328	553	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase	endoplasmic reticulum organization|glutaminyl-tRNAGln biosynthesis via transamidation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YOR162C	YOR162C	YRR1	hom	Verified	1.12678095914234	0.12991755145322	no	622	0.185350314274189	671	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YDR337W	YDR337W	MRPS28	hom	Verified	1.12259194850653	0.13080541823455	no	623	0.158918278285531	553	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome|RNA binding	mitochondrion|mitochondrial small ribosomal subunit
YOL056W	YOL056W	GPM3	hom	Verified	1.1216483701133	0.131005988392297	no	624	0.125998662742282	490	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event	biological_process	phosphoglycerate mutase activity|molecular_function	cytosol
YDL026W_d	YDL026W	YDL026W	hom	Dubious	1.12097427690669	0.131149405944307	no	625	0.142144551249047	502	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR246W	YLR246W	ERF2	hom	Verified	1.12023691531341	0.131306408396149	no	626	0.105802808838352	386	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole	protein targeting to membrane|protein palmitoylation	palmitoyltransferase activity	endoplasmic reticulum palmitoyltransferase complex|integral to endoplasmic reticulum membrane|integral to membrane
YPL253C	YPL253C	VIK1	hom	Verified	1.12012433389448	0.13133039117044	no	627	0.134733166688967	531	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p	microtubule-based process|mitotic sister chromatid cohesion	microtubule motor activity	kinesin complex|spindle pole body
YNL298W	YNL298W	CLA4	hom	Verified	1.11953894439061	0.131455143132777	no	628	0.197543704952328	691	NA	FF|FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p	negative regulation of gene expression|vacuole inheritance|protein phosphorylation|budding cell apical bud growth|Rho protein signal transduction|regulation of exit from mitosis|establishment of cell polarity|sterol import|response to pheromone|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	nucleus|cellular bud|fungal-type vacuole
YGL226W	YGL226W	MTC3	hom	Verified	1.11884489252786	0.131603158023928	no	629	0.118405020591395	472	NA	FT		MITOCHONDRION		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1	biological_process	molecular_function	mitochondrion
YDR178W	YDR178W	SDH4	hom	Verified	1.11701709534975	0.131993507894471	no	630	0.159123971734927	532	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain	mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion
YOR209C	YOR209C	NPT1	hom	Verified	1.11565441040216	0.132285046078271	no	631	0.190430852706793	690	NA	FF|FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus	chromatin silencing at rDNA|replicative cell aging|nicotinate nucleotide salvage|chromatin silencing at telomere	nicotinate phosphoribosyltransferase activity	nucleus
YGR242W_d	YGR242W	YGR242W	hom	Dubious	1.11026177603651	0.133443119653347	no	632	0.135186780797399	505	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C	Unknown	Unknown	Unknown
YOR104W	YOR104W	PIN2	hom	Verified	1.1099366805731	0.133513156409509	no	633	0.143046031909636	506	NA					Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated	biological_process	molecular_function	cellular_component
YOR192C	YOR192C	THI72	hom	Verified	1.1091571297528	0.133681201474539	no	634	0.145245678965719	533	NA					Transporter of thiamine or related compound; shares sequence similarity with Thi7p	thiamine transport	transporter activity	integral to membrane|membrane
YDL200C	YDL200C	MGT1	hom	Verified	1.10849917637555	0.133823147319025	no	635	0.156147759405145	537	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage	DNA dealkylation involved in DNA repair	methylated-DNA-[protein]-cysteine S-methyltransferase activity	nucleus
YDR195W	YDR195W	REF2	hom	Verified	1.10841888778022	0.133840475746145	no	636	0.157219028044872	552	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes	mRNA 3'-end processing|termination of RNA polymerase II transcription, poly(A)-coupled|snoRNA 3'-end processing|Unknown	chromatin binding|RNA binding	mRNA cleavage and polyadenylation specificity factor complex|nucleus
YDR315C	YDR315C	IPK1	hom	Verified	1.10752248452495	0.134034048286377	no	637	0.18488258806408	580	NA	FT		NUCLEUS		Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable	nuclear-transcribed mRNA catabolic process, non-stop decay|inositol phosphate biosynthetic process	inositol pentakisphosphate 2-kinase activity	nucleus
YOR001W	YOR001W	RRP6	hom	Verified	1.10535695937218	0.134502472936829	no	638	0.081657493663275	334	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay	nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U1 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear retention of pre-mRNA at the site of transcription|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription	3'-5'-exoribonuclease activity	nucleolus|nucleus|nuclear exosome (RNase complex)
YLR387C	YLR387C	REH1	hom	Verified	1.10439870174421	0.134710111860965	no	639	0.165275239791301	550	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS		RIBOSOME	Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains	ribosomal large subunit biogenesis|budding cell bud growth	molecular_function	cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YBL007C	YBL007C	SLA1	hom	Verified	1.10403093725622	0.134789858854252	no	640	0.191124063334469	669	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains	fungal-type cell wall organization|endocytosis|actin cortical patch assembly	ubiquitin binding|protein binding, bridging	cell cortex|nucleus|mating projection tip|actin cortical patch
YMR242C	YMR242C	RPL20A	hom	Verified	1.10394981733678	0.134807453464814	no	641	0.13577839786163	553	NA	FF|FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YHR048W_p	YHR048W	YHK8	hom	Uncharacterized	1.1022273765236	0.135181416482208	no	642	0.153982867640517	531	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles	drug transport	molecular_function	integral to membrane
YMR261C	YMR261C	TPS3	hom	Verified	1.10158112752123	0.135321908385925	no	643	0.128114469501763	453	NA	FT	CARBOHYDRATE METABOLISM			Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication	trehalose biosynthetic process|response to stress	enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YGL221C	YGL221C	NIF3	hom	Verified	1.10019132351289	0.135624385088454	no	644	0.125780001598278	450	NA	FT		MITOCHONDRION		Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YJL141C	YJL141C	YAK1	hom	Verified	1.09952321592761	0.135769956632904	no	645	0.120668102557695	470	NA	FT	PROTEIN PHOSPHORYLATION	NUCLEUS		Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose	protein phosphorylation	protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity	nucleus|cytoplasm
YLR113W	YLR113W	HOG1	hom	Verified	1.09912940398803	0.135855813003001	no	646	0.163675534976796	509	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase II promoter by pheromones|protein phosphorylation|hyperosmotic response|response to arsenic-containing substance|osmosensory signaling pathway|positive regulation of transcription from RNA polymerase II promoter|cellular response to heat	MAP kinase activity	nucleus|cytoplasm
YKL068W	YKL068W	NUP100	hom	Verified	1.09795630577916	0.136111784691439	no	647	0.123189451651871	474	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; homologous to Nup116p	positive regulation of transcription, DNA-dependent|mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|protein import into nucleus|protein targeting to nuclear inner membrane|mRNA export from nucleus in response to heat stress	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore
YDR276C	YDR276C	PMP3	hom	Verified	1.09581848633402	0.136579108390516	no	648	0.144111007657273	552	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential	regulation of membrane potential|cation transport	molecular_function	plasma membrane
YNR025C_d	YNR025C	YNR025C	hom	Dubious	1.09408506384052	0.136958836254956	no	649	0.129483143938386	502	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase	Unknown	Unknown	Unknown
YDL170W	YDL170W	UGA3	hom	Verified	1.09226363427909	0.137358619838716	no	650	0.132259933380665	422	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus	nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process	sequence-specific DNA binding transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YNL217W_p	YNL217W	YNL217W	hom	Uncharacterized	1.0901286957605	0.137828228680222	no	651	0.123834178247133	450	NA					Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate	biological_process	phosphatase activity	fungal-type vacuole
YMR052C-A_d	YMR052C-A	YMR052C-A	hom	Dubious	1.09009624862643	0.137835374310262	no	652	0.136573747757483	529	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL148C	YKL148C	SDH1	hom	Verified	1.09003898795731	0.13784798508701	no	653	0.173938429487138	673	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits	cellular respiration|mitochondrial electron transport, succinate to ubiquinone|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity|flavin adenine dinucleotide binding	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial membrane
YGR212W	YGR212W	SLI1	hom	Verified	1.08946876353674	0.137973611147203	no	654	0.145704979728477	508	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin	response to drug	N-acetyltransferase activity	nuclear envelope|plasma membrane
YBR286W	YBR286W	APE3	hom	Verified	1.08827173831812	0.138237581564117	no	655	0.147224135768334	550	NA	FT	PROTEOLYSIS			Vacuolar aminopeptidase Y, processed to mature form by Prb1p	vacuolar protein catabolic process	aminopeptidase activity	fungal-type vacuole
YOL121C	YOL121C	RPS19A	hom	Verified	1.08593436146331	0.138754016631969	no	656	0.140593372804964	506	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit biogenesis|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR524W-C_p	YDR524W-C	YDR524W-C	hom	Uncharacterized	1.08485845408939	0.138992175615258	no	657	0.157195297361987	563	NA					Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin	biological_process	molecular_function	cellular_component
YGL192W	YGL192W	IME4	hom	Verified	1.08454516093614	0.139061577346008	no	658	0.163747114717971	564	NA	FT	CELL CYCLE	NUCLEUS		Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids	meiosis|mRNA methylation	mRNA (N6-adenosine)-methyltransferase activity	cellular_component
YOL090W	YOL090W	MSH2	hom	Verified	1.08205045425734	0.139615054723454	no	659	0.149846213671587	538	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP	mismatch repair|mitotic recombination|meiotic gene conversion|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination|chromatin silencing at silent mating-type cassette	loop DNA binding|single base insertion or deletion binding|ATP binding|Y-form DNA binding|double-strand/single-strand DNA junction binding|DNA insertion or deletion binding|guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity	MutSbeta complex|nuclear chromosome|MutSalpha complex|nucleus
YGL140C_p	YGL140C	YGL140C	hom	Uncharacterized	1.07949789365467	0.14018291613609	no	660	0.0950030885165264	365	NA					Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains	biological_process	molecular_function	integral to membrane
YDR289C	YDR289C	RTT103	hom	Verified	1.07832830247543	0.140443635419713	no	661	0.161777969408614	588	NA	FT	RNA PROCESSING	NUCLEUS|CHROMOSOME		Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition	negative regulation of transposition, RNA-mediated|mRNA 3'-end processing	RNA polymerase II core binding	nuclear chromatin|site of double-strand break
YGR183C	YGR183C	QCR9	hom	Verified	1.07729495193122	0.140674258405139	no	662	0.141345850132767	528	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex	iron-sulfur cluster assembly|mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YJL056C	YJL056C	ZAP1	hom	Verified	1.07652629218539	0.140845974351195	no	663	0.230885802806839	790	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains	regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II regulatory region sequence-specific DNA binding|zinc ion binding	nucleus
YMR297W	YMR297W	PRC1	hom	Verified	1.07597415214817	0.14096940826515	no	664	0.105716181708662	371	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family	vacuolar protein catabolic process|phytochelatin biosynthetic process	serine-type carboxypeptidase activity	fungal-type vacuole lumen|endoplasmic reticulum|fungal-type vacuole|cytoplasm
YBR093C	YBR093C	PHO5	hom	Verified	1.07473888385227	0.141245824858922	no	665	0.129175832638385	499	NA	FT	RESPONSE TO NUTRIENT LEVELS			Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2	cellular response to phosphate starvation|phosphate-containing compound metabolic process|regulation of cell size	nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|acid phosphatase activity	fungal-type cell wall|cell wall-bounded periplasmic space
YML096W_p	YML096W	YML096W	hom	Uncharacterized	1.0745243936972	0.141293858841355	no	666	0.158150682680434	551	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10	biological_process	molecular_function	cytoplasm
YNL012W	YNL012W	SPO1	hom	Verified	1.07265754543427	0.141712397630191	no	667	0.120004185234369	452	NA	FT	CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B	meiosis|spore membrane bending pathway	phospholipase activity	endoplasmic reticulum|nucleus|prospore membrane
YFR030W	YFR030W	MET10	hom	Verified	1.0714496080714	0.141983658659582	no	668	0.142883654088494	519	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide	sulfate assimilation	sulfite reductase (NADPH) activity	sulfite reductase complex (NADPH)
YOL103W	YOL103W	ITR2	hom	Verified	1.06927215446499	0.142473527013779	no	669	0.144656383917355	498	NA	FT		PLASMA MEMBRANE		Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively	myo-inositol transport	myo-inositol transmembrane transporter activity	integral to membrane|plasma membrane|membrane
YDR215C_d	YDR215C	YDR215C	hom	Dubious	1.06882959848111	0.142573229793097	no	670	0.141874313476541	441	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein	Unknown	Unknown	Unknown
YAL018C_p	YAL018C	YAL018C	hom	Uncharacterized	1.06868669038534	0.142605435421037	no	671	0.14989220416904	505	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YDR539W	YDR539W	FDC1	hom	Verified	1.06757065062087	0.142857114258271	no	672	0.136216643552639	525	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	PLASMA MEMBRANE		Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm	cinnamic acid catabolic process	molecular_function	cytoplasm
YLR021W	YLR021W	IRC25	hom	Verified	1.066648134682	0.143065377923334	no	673	0.151303592134631	543	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions	proteasome assembly|chaperone-mediated protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	intracellular
YPL176C	YPL176C	TRE1	hom	Verified	1.0654290463333	0.143340909142464	no	674	0.16898204861623	615	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	molecular_function	fungal-type vacuole
YLR192C	YLR192C	HCR1	hom	Verified	1.06486941311233	0.143467514095742	no	675	0.187815755539933	662	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION			Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	translation initiation factor activity	eukaryotic translation initiation factor 3 complex
YKL085W	YKL085W	MDH1	hom	Verified	1.06411958783708	0.14363726420536	no	676	0.149480462370804	505	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated	chronological cell aging|replicative cell aging|tricarboxylic acid cycle|aerobic respiration	L-malate dehydrogenase activity|mRNA binding	mitochondrion|mitochondrial matrix
YER130C_p	YER130C	YER130C	hom	Uncharacterized	1.06406944629754	0.143648620392219	no	677	0.199726949630177	694	NA	FT		NUCLEUS		Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress	biological_process	sequence-specific DNA binding	cellular_component
YIR002C	YIR002C	MPH1	hom	Verified	1.06068418473909	0.144416724845949	no	678	0.148793842769499	542	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases	negative regulation of strand invasion|recombinational repair|DNA replication, Okazaki fragment processing	flap-structured DNA binding|3'-5' DNA helicase activity	nucleus
YPL250C	YPL250C	ICY2	hom	Verified	1.06007424601718	0.144555411614245	no	679	0.165229005003439	587	NA					Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate	mitochondrion degradation	molecular_function	cellular_component
YOR187W	YOR187W	TUF1	hom	Verified	1.06000116511234	0.144572034636397	no	680	0.227771239164109	696	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans	mitochondrial translational elongation|mitochondrial translation	GTPase activity|translation elongation factor activity	mitochondrion|mitochondrial matrix
YNR032W	YNR032W	PPG1	hom	Verified	1.05760332493724	0.145118163019984	no	681	0.139979023719076	442	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases	glycogen metabolic process|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YKR059W	YKR059W	TIF1	hom	Verified	1.05684920491051	0.145290206859277	no	682	0.143725410581325	495	NA	FT	TRANSLATION		RIBOSOME	Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication	translational initiation	ATP-dependent RNA helicase activity|translation initiation factor activity	ribosome|eukaryotic translation initiation factor 4F complex
YLR090W	YLR090W	XDJ1	hom	Verified	1.0564572972421	0.145379670267349	no	683	0.158151374481596	546	NA	FT		NUCLEUS|MITOCHONDRION		Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	protein folding	chaperone binding	mitochondrion|integral to mitochondrial outer membrane|nucleus
YMR207C	YMR207C	HFA1	hom	Verified	1.05617179579374	0.145444866935048	no	684	0.133590409442852	517	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	fatty acid biosynthetic process	acetyl-CoA carboxylase activity	mitochondrion
YLR363C	YLR363C	NMD4	hom	Verified	1.05571292877988	0.145549694291169	no	685	0.144138982898107	535	NA					Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	molecular_function	cytoplasm
YJL053W	YJL053W	PEP8	hom	Verified	1.05306465027889	0.146155681407293	no	686	0.161755302375637	607	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YNL116W	YNL116W	DMA2	hom	Verified	1.05243294023583	0.146300481186027	no	687	0.182004015086143	623	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION			Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains	establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint	ubiquitin-protein ligase activity	cytoplasm
YMR306W	YMR306W	FKS3	hom	Verified	1.0522138011048	0.146350734478086	no	688	0.159841653398849	601	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	ascospore wall assembly	1,3-beta-D-glucan synthase activity	mitochondrion|integral to membrane
YIL158W	YIL158W	AIM20	hom	Verified	1.05074253682732	0.146688426961598	no	689	0.152752318857807	540	NA	FT	CELL CYCLE			Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress	biological_process	molecular_function	fungal-type vacuole
YPL178W	YPL178W	CBC2	hom	Verified	1.04429231155869	0.148175084465468	no	690	0.129509040570403	471	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif	mRNA splicing, via spliceosome	RNA cap binding	commitment complex|nuclear cap binding complex
YNR020C	YNR020C	ATP23	hom	Verified	1.04395516365308	0.148253067086972	no	691	0.168850106925993	564	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p	protein processing|mitochondrial proton-transporting ATP synthase complex assembly	metalloendopeptidase activity	mitochondrial inner membrane|mitochondrial intermembrane space
YOR293C-A_p	YOR293C-A	YOR293C-A	hom	Uncharacterized	1.0408609926514	0.148970033860855	no	692	0.12908347822411	406	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YNL228W_d	YNL228W	YNL228W	hom	Dubious	1.03819222546564	0.149590285721153	no	693	0.172147497935743	605	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1	Unknown	Unknown	Unknown
YNL215W	YNL215W	IES2	hom	Verified	1.03712167357849	0.149839577764708	no	694	0.167793776636275	576	NA	FT		NUCLEUS		Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YPL023C	YPL023C	MET12	hom	Verified	1.03625177287422	0.150042349494025	no	695	0.157102976564052	556	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR	biological_process	methylenetetrahydrofolate reductase (NADPH) activity	cellular_component
YPR157W_p	YPR157W	TDA6	hom	Uncharacterized	1.03617308547331	0.150060700353663	no	696	0.154628620850552	531	NA	FT	PROTEIN LOCALIZATION			Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	cellular_component
YFL013C	YFL013C	IES1	hom	Verified	1.03387931305653	0.150596293571275	no	697	0.182016651746799	600	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the INO80 chromatin remodeling complex	nucleosome mobilization	molecular_function	nucleus|Ino80 complex
YJL198W	YJL198W	PHO90	hom	Verified	1.03343499738383	0.150700187783825	no	698	0.15601903115899	533	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication	phosphate ion transport	phosphate ion transmembrane transporter activity	integral to membrane|membrane
YDR313C	YDR313C	PIB1	hom	Verified	1.03271248898317	0.150869233609492	no	699	0.148233839215772	536	NA					RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain	protein ubiquitination	ubiquitin-protein ligase activity|phosphatidylinositol-3-phosphate binding	fungal-type vacuole membrane|late endosome
YGR057C	YGR057C	LST7	hom	Verified	1.03189394592048	0.15106090118797	no	700	0.210083034139942	733	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface	intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport	protein transporter activity	vesicle coat
YGR050C_p	YGR050C	YGR050C	hom	Uncharacterized	1.02956351722493	0.151607474332816	no	701	0.13551049120257	541	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YNL111C	YNL111C	CYB5	hom	Verified	1.02941791334132	0.151641667495718	no	702	0.20296870318054	698	NA	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation	sterol biosynthetic process	electron carrier activity	endoplasmic reticulum membrane
YGL090W	YGL090W	LIF1	hom	Verified	1.0293026496001	0.151668739308741	no	703	0.154099914251783	579	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein	double-strand break repair via nonhomologous end joining	chromatin binding	DNA ligase IV complex|nuclear chromatin|nucleus
YML094C-A_d	YML094C-A	YML094C-A	hom	Dubious	1.02905624009022	0.151726623894555	no	704	0.158464964806777	605	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YKL006W	YKL006W	RPL14A	hom	Verified	1.02757073166202	0.15207589887725	no	705	0.175520822630112	586	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YKL080W	YKL080W	VMA5	hom	Verified	1.02459900234539	0.152776217728371	no	706	0.212238337043107	707	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YBR196C-B_p	YBR196C-B	YBR196C-B	hom	Uncharacterized	1.02299484851056	0.153155140755774	no	707	0.14043575754294	504	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YER041W	YER041W	YEN1	hom	Verified	1.02274211562006	0.15321489646053	no	708	0.14603979350807	543	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p	DNA repair|response to DNA damage stimulus	single-stranded DNA specific endodeoxyribonuclease activity|crossover junction endodeoxyribonuclease activity	nucleus|cytoplasm
YGR035W-A_p	YGR035W-A	YGR035W-A	hom	Uncharacterized	1.02217927472304	0.153348029046741	no	709	0.133266005741867	452	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGL028C	YGL028C	SCW11	hom	Verified	1.02212691343245	0.153360418314345	no	710	0.164593173770994	562	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM			Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p	cytokinesis, completion of separation	glucan endo-1,3-beta-D-glucosidase activity	fungal-type cell wall
YDR520C_p	YDR520C	URC2	hom	Uncharacterized	1.02098691229705	0.153630319724137	no	711	0.188528614526143	560	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism	uracil catabolic process	sequence-specific DNA binding	nucleus|cytoplasm
YGL066W	YGL066W	SGF73	hom	Verified	1.01985246972985	0.153899217145904	no	712	0.184740031823659	617	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RNA LOCALIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay	histone deubiquitination|mRNA export from nucleus|histone acetylation|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|protein complex assembly|chromatin modification	histone acetyltransferase activity|enzyme activator activity|structural molecule activity	DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YPR002W	YPR002W	PDH1	hom	Verified	1.01950974961034	0.153980513471529	no	713	0.165024497180238	599	NA	FT	KETONE METABOLISM	MITOCHONDRION		Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate	propionate metabolic process|propionate catabolic process, 2-methylcitrate cycle	2-methylcitrate dehydratase activity	mitochondrial outer membrane|mitochondrion|cytoplasm
YNL094W	YNL094W	APP1	hom	Verified	1.01932960738578	0.154023256234837	no	714	0.171824047494567	604	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway	actin cytoskeleton organization	molecular_function	actin cytoskeleton|actin cortical patch
YDL095W	YDL095W	PMT1	hom	Verified	1.01902257895495	0.15409612367224	no	715	0.187050354176178	604	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen	ER-associated misfolded protein catabolic process|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YGL242C_p	YGL242C	YGL242C	hom	Uncharacterized	1.01823801213478	0.15428242946527	no	716	0.176930353972997	579	NA					Putative protein of unknown function; deletion mutant is viable	biological_process	molecular_function	cellular_component
YLR439W	YLR439W	MRPL4	hom	Verified	1.01816500414425	0.154299773752844	no	717	0.195528191099655	660	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDL182W	YDL182W	LYS20	hom	Verified	1.01798743140199	0.154341964553982	no	718	0.126450111981053	449	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication	lysine biosynthetic process via aminoadipic acid	homocitrate synthase activity	mitochondrion|nucleus
YDR181C	YDR181C	SAS4	hom	Verified	1.01654984543456	0.154683811907524	no	719	0.194214697465632	660	NA	FT	CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p	chromatin silencing at telomere	acetyltransferase activity|histone acetyltransferase activity	nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YDR320C	YDR320C	SWA2	hom	Verified	1.01647899238209	0.154700673168379	no	720	0.21700800836149	710	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles	positive regulation of ATPase activity|endoplasmic reticulum inheritance|clathrin coat disassembly	ubiquitin binding|clathrin binding	endoplasmic reticulum membrane
YDR296W	YDR296W	MHR1	hom	Verified	1.01439041460362	0.155198248158162	no	721	0.17929354040318	620	NA	FT	MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress	cellular response to oxidative stress|positive regulation of mitochondrial DNA replication|regulation of transcription, DNA-dependent|mitochondrial genome maintenance|DNA recombination	single-stranded DNA binding|recombinase activity|DNA binding	mitochondrion|nucleus
YBL062W_d	YBL062W	YBL062W	hom	Dubious	1.01330814359425	0.155456499469714	no	722	0.18222474894714	614	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR318C	YMR318C	ADH6	hom	Verified	1.01250973388181	0.155647197483697	no	723	0.149431368064258	511	NA	FT	OXIDATION-REDUCTION PROCESS			NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress	cellular aldehyde metabolic process|furaldehyde metabolic process|alcohol metabolic process	hydroxymethylfurfural reductase (NADH) activity|hydroxymethylfurfural reductase (NADPH) activity|alcohol dehydrogenase (NADP+) activity	cellular_component
YLL014W	YLL014W	EMC6	hom	Verified	1.01218157607872	0.15572562181316	no	724	0.186635855962177	688	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|integral to membrane|endoplasmic reticulum
YOR008C-A_p	YOR008C-A	YOR008C-A	hom	Uncharacterized	1.01102315493371	0.15600267377328	no	725	0.139108564439166	459	NA					Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres	biological_process	molecular_function	cellular_component
YLR320W	YLR320W	MMS22	hom	Verified	1.01007323726427	0.156230101603069	no	726	0.156899050320496	567	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation	replication fork processing|double-strand break repair|recombinational repair|meiotic sister chromatid segregation|response to DNA damage stimulus	molecular_function	Cul8-RING ubiquitin ligase complex|nucleus
YGR208W	YGR208W	SER2	hom	Verified	1.00661625072889	0.157059611017255	no	727	0.1445379940222	529	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source	L-serine biosynthetic process	phosphoserine phosphatase activity	nucleus|cytoplasm
YPR018W	YPR018W	RLF2	hom	Verified	1.00531787719615	0.157371904761302	no	728	0.150553453727897	531	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription	DNA replication-dependent nucleosome assembly	histone binding	chromosome, centromeric region|nucleus|CAF-1 complex
YCR075C	YCR075C	ERS1	hom	Verified	1.00523173438456	0.157392638852598	no	729	0.144232423635952	544	NA					Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains	L-cystine transport|transmembrane transport	L-cystine transmembrane transporter activity	endosome|integral to membrane|fungal-type vacuole
YDR244W	YDR244W	PEX5	hom	Verified	1.00427940564397	0.157621978683283	no	730	0.180956119465945	565	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions	protein import into peroxisome matrix, docking	peroxisome matrix targeting signal-1 binding|protein binding, bridging	cytosol|peroxisomal membrane|peroxisome
YML063W	YML063W	RPS1B	hom	Verified	1.00356076698241	0.157795186542489	no	731	0.175687729747112	600	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YMR078C	YMR078C	CTF18	hom	Verified	1.00181688680176	0.158216019897521	no	732	0.137186645494388	491	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint	maintenance of DNA trinucleotide repeats|double-strand break repair via homologous recombination|DNA replication initiation|mitotic sister chromatid cohesion	molecular_function	mitochondrion|nuclear replication fork|Ctf18 RFC-like complex
YMR286W	YMR286W	MRPL33	hom	Verified	1.00095700204905	0.158423798257062	no	733	0.159458837410724	602	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOL012C	YOL012C	HTZ1	hom	Verified	1.00092758348221	0.15843090998135	no	734	0.181945471353318	691	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin	nuclear-transcribed mRNA catabolic process, non-stop decay|regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	chromatin binding	nuclear chromatin|chromatin assembly complex
YER046W-A_d	YER046W-A	YER046W-A	hom	Dubious	0.999790420481083	0.158705971353603	no	735	0.147238577894059	530	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL098C_p	YOL098C	YOL098C	hom	Uncharacterized	0.997731344000941	0.159204824954167	no	736	0.160611366281603	608	NA	FT	PROTEOLYSIS			Putative metalloprotease	biological_process	molecular_function	cytoplasm
YCR101C_p	YCR101C	YCR101C	hom	Uncharacterized	0.997477334066209	0.15926643516626	no	737	0.160341218829982	619	NA					Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene	biological_process	molecular_function	integral to membrane|membrane
YDL100C	YDL100C	GET3	hom	Verified	0.997379017407696	0.159290286102282	no	738	0.228650048231313	768	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress	retrograde vesicle-mediated transport, Golgi to ER|pheromone-dependent signal transduction involved in conjugation with cellular fusion|response to heat|protein insertion into ER membrane|response to metal ion|posttranslational protein targeting to membrane	ATPase activity|guanyl-nucleotide exchange factor activity	endoplasmic reticulum|GET complex
YKR001C	YKR001C	VPS1	hom	Verified	0.99641604814105	0.159524019378084	no	739	0.253501621638566	835	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION	MITOCHONDRION|CYTOSKELETON		Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis	vacuolar transport|peroxisome fission|endocytosis|actin cytoskeleton organization|protein retention in Golgi apparatus|peroxisome organization|lipid tube assembly|protein targeting to vacuole	GTPase activity	mitochondrial outer membrane|fungal-type vacuole membrane|peroxisome|actin cortical patch
YDR143C	YDR143C	SAN1	hom	Verified	0.995598274365151	0.159722686779087	no	740	0.157931158064764	497	NA	FT	PROTEOLYSIS	NUCLEUS		Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition	nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to misfolded protein|response to stress	ubiquitin-protein ligase activity	nucleus|cytoplasm
YKL050C	YKL050C	YKL050C	hom	Verified	0.994401049093666	0.160013828798506	no	741	0.112193737089419	406	NA					Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p	biological_process	molecular_function	cellular_component
YPL066W	YPL066W	RGL1	hom	Verified	0.994348175220874	0.160026694697868	no	742	0.199525082076153	735	NA	FF|FT		SITE OF POLARIZED GROWTH		Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source	protein localization to bud neck	molecular_function	cellular bud neck|cytoplasm
YOR036W	YOR036W	PEP12	hom	Verified	0.993764799112694	0.160168693613426	no	743	0.203778958435159	730	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin	Golgi to vacuole transport|vacuole inheritance	SNAP receptor activity	endosome|Golgi apparatus
YOL117W	YOL117W	RRI2	hom	Verified	0.992287749390294	0.160528588793026	no	744	0.1564254011356	571	NA	FT	SIGNALING	NUCLEUS		Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	molecular_function	signalosome
YML107C	YML107C	PML39	hom	Verified	0.991589223532408	0.160698974150976	no	745	0.149130067070607	480	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes	maintenance of RNA location	molecular_function	ribosome|nuclear pore
YBR281C	YBR281C	DUG2	hom	Verified	0.991155488460168	0.160804830799629	no	746	0.154472756398292	574	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS	NUCLEUS		Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	peptidase activity|gamma-glutamyltransferase activity|omega peptidase activity	nucleus|cytoplasm
YNL198C_d	YNL198C	YNL198C	hom	Dubious	0.989433589035757	0.161225523695787	no	747	0.150922049882724	523	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR009W	YOR009W	TIR4	hom	Verified	0.987757349742292	0.161635750017047	no	748	0.161447045268618	554	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock	biological_process	molecular_function	fungal-type cell wall
YOR325W_d	YOR325W	YOR325W	hom	Dubious	0.986553189916827	0.161930863822853	no	749	0.164494432943855	605	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1	Unknown	Unknown	Unknown
YBL047C	YBL047C	EDE1	hom	Verified	0.986473420090016	0.16195042608949	no	750	0.11124745918773	491	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING	SITE OF POLARIZED GROWTH|CYTOSKELETON		Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death	endoplasmic reticulum unfolded protein response|endocytosis	ubiquitin binding	cellular bud neck|mating projection tip|actin cortical patch|cellular bud tip
YJL030W	YJL030W	MAD2	hom	Verified	0.98607103565071	0.162049127867563	no	751	0.15060503531257	529	NA	FT	CELL CYCLE|CELL DIVISION	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME	NUCLEAR PORE|KINETOCHORE	Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I	chromosome decondensation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	mitotic checkpoint complex|condensed nuclear chromosome kinetochore|nuclear pore
YGL232W	YGL232W	TAN1	hom	Verified	0.986030514727357	0.162059069506279	no	752	0.167962993246301	564	NA	FT	RNA PROCESSING	NUCLEUS		Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress	tRNA modification	RNA binding	nucleus|cytoplasm
YJL136W-A_p	YJL136W-A	YJL136W-A	hom	Uncharacterized	0.985723051550635	0.162134517250002	no	753	0.128738054956245	401	NA					Putative protein of unknown function; identified by SAGE	biological_process	molecular_function	cellular_component
YPR114W_p	YPR114W	YPR114W	hom	Uncharacterized	0.985715250656156	0.162136431792612	no	754	0.172361858884064	602	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YOL119C	YOL119C	MCH4	hom	Verified	0.98501667482179	0.162307940179097	no	755	0.140569615888351	508	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	fungal-type vacuole membrane|integral to membrane
YGR130C	YGR130C	YGR130C	hom	Verified	0.984855635543606	0.162347493915039	no	756	0.186133498566706	642	NA					Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)	biological_process	molecular_function	eisosome|membrane raft|cytoplasm
YLR318W	YLR318W	EST2	hom	Verified	0.9840222188849	0.162552294177114	no	757	0.158495762059506	595	NA	FT		NUCLEUS|CHROMOSOME		Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia	telomere maintenance via telomerase|replicative cell aging	telomerase activity|telomeric template RNA reverse transcriptase activity|telomeric DNA binding	telomerase catalytic core complex|nucleolus|nucleus|telomerase holoenzyme complex
YHR111W	YHR111W	UBA4	hom	Verified	0.982395563618094	0.162952505535392	no	758	0.172807094025906	628	NA	FT	RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS			Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p	cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|tRNA thio-modification|Unknown|invasive growth in response to glucose limitation	URM1 activating enzyme activity|sulfurtransferase activity|thiosulfate sulfurtransferase activity|protein adenylyltransferase activity	cytoplasm
YIL093C	YIL093C	RSM25	hom	Verified	0.981212019746823	0.163244099009233	no	759	0.180946649673354	669	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YLR240W	YLR240W	VPS34	hom	Verified	0.980431283098308	0.163436637060874	no	760	0.175117046278657	661	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	GOLGI APPARATUS		Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery	peroxisome degradation|phosphatidylinositol phosphorylation|protein phosphorylation	1-phosphatidylinositol-3-kinase activity|protein kinase activity	endosome|fungal-type vacuole membrane|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|peroxisome|pre-autophagosomal structure
YGL143C	YGL143C	MRF1	hom	Verified	0.978840133795151	0.163829488007078	no	761	0.216819575905234	725	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability	translational termination|mitochondrial translational termination|mitochondrial translation	translation release factor activity	mitochondrion
YBR245C	YBR245C	ISW1	hom	Verified	0.97841911384296	0.163933539273194	no	762	0.152760738280938	580	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions	termination of RNA polymerase I transcription|nucleosome positioning|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|regulation of transcriptional start site selection at RNA polymerase II promoter|heterochromatin maintenance involved in chromatin silencing|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	nucleosome binding|ATPase activity|rDNA binding|DNA binding	ISW1 complex|nucleolar chromatin
YGL228W	YGL228W	SHE10	hom	Verified	0.977284480653691	0.164214167032784	no	763	0.160362948956863	580	NA	FT		MITOCHONDRION		Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest	biological_process	molecular_function	cellular_component
YDR322W	YDR322W	MRPL35	hom	Verified	0.976744929141471	0.164347723032177	no	764	0.186223229114766	628	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YJL007C_d	YJL007C	YJL007C	hom	Dubious	0.976525147995978	0.164402145970505	no	765	0.159121935014002	548	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR060W	YHR060W	VMA22	hom	Verified	0.975728508885339	0.164599510306005	no	766	0.167424913346815	570	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)	vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification	unfolded protein binding	extrinsic to endoplasmic reticulum membrane
YMR279C	YMR279C	YMR279C	hom	Verified	0.975371923733378	0.164687902655439	no	767	0.183696242724074	618	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication	borate transmembrane transport	borate efflux transmembrane transporter activity	integral to membrane
YGL262W_p	YGL262W	YGL262W	hom	Uncharacterized	0.975277075284265	0.164711419404009	no	768	0.143557317541431	500	NA					Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene	biological_process	molecular_function	cellular_component
YJL077W-B_p	YJL077W-B	YJL077W-B	hom	Uncharacterized	0.974901719505312	0.164804506551123	no	769	0.210333885554048	668	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YHL035C	YHL035C	VMR1	hom	Verified	0.974789450488263	0.164832355561694	no	770	0.171922423788311	593	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions	transport|response to drug|response to metal ion|drug transport	ATPase activity, coupled to transmembrane movement of substances	fungal-type vacuole membrane|mitochondrion|integral to membrane|ribosome
YDL159W-A_p	YDL159W-A	YDL159W-A	hom	Uncharacterized	0.974017946391366	0.165023814270176	no	771	0.152648997260426	582	NA					Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	cellular_component
YPR068C	YPR068C	HOS1	hom	Verified	0.973994310036164	0.165029682209378	no	772	0.139007558887812	540	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex	peptidyl-lysine deacetylation|histone H4 deacetylation|positive regulation of transcription from RNA polymerase II promoter	histone deacetylase activity|protein deacetylase activity	histone deacetylase complex
YMR205C	YMR205C	PFK2	hom	Verified	0.972027718618779	0.165518379528907	no	773	0.258488740485721	898	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes	proton transport|glycolysis	mRNA binding|6-phosphofructokinase activity	mitochondrion|6-phosphofructokinase complex|cytoplasm
YPL203W	YPL203W	TPK2	hom	Verified	0.971608983097791	0.16562255591875	no	774	0.161963048393792	597	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase	protein phosphorylation|Ras protein signal transduction|invasive growth in response to glucose limitation	cAMP-dependent protein kinase activity|protein kinase activity	nucleus|cAMP-dependent protein kinase complex
YOR376W-A_p	YOR376W-A	YOR376W-A	hom	Uncharacterized	0.971563245915031	0.165633937350938	no	775	0.14551903078452	488	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YJL124C	YJL124C	LSM1	hom	Verified	0.971409384948676	0.165672228470916	no	776	0.198191229434515	677	NA	FF|FT	RNA PROCESSING	NUCLEUS		Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	RNA binding|RNA cap binding	mRNA cap binding complex|cytoplasmic mRNA processing body|cytoplasm
YMR304W	YMR304W	UBP15	hom	Verified	0.970886784055625	0.165802330011513	no	777	0.201014181912354	602	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p	protein deubiquitination	ubiquitin-specific protease activity	peroxisome|cytoplasm
YJL190C	YJL190C	RPS22A	hom	Verified	0.969597365978764	0.166123613190907	no	778	0.170333138083536	597	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR278C_d	YDR278C	YDR278C	hom	Dubious	0.968300655493939	0.166447118753914	no	779	0.150826216594498	538	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR095C	YBR095C	RXT2	hom	Verified	0.96743629617696	0.166662986369731	no	780	0.20264071553525	702	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth	conjugation with cellular fusion|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|invasive growth in response to glucose limitation	histone deacetylase activity	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YJR036C	YJR036C	HUL4	hom	Verified	0.966399725508718	0.16692210068947	no	781	0.171711178585138	579	NA	FT	PROTEOLYSIS	NUCLEUS		Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex	protein ubiquitination	ubiquitin-protein ligase activity	TRAMP complex
YPL137C	YPL137C	GIP3	hom	Verified	0.965430033322454	0.167164732321213	no	782	0.16906273998331	573	NA	FT	CHROMOSOME SEGREGATION	ENDOPLASMIC RETICULUM|MITOCHONDRION		Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication	chromosome segregation|regulation of phosphoprotein phosphatase activity	protein phosphatase type 1 regulator activity|protein phosphatase 1 binding	mitochondrion|ribosome|endoplasmic reticulum|cytoplasm
YLR357W	YLR357W	RSC2	hom	Verified	0.963841008270615	0.167562821699127	no	783	0.173422932957274	589	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance	ATP-dependent chromatin remodeling|chromosome segregation|nucleosome disassembly|plasmid maintenance|sister chromatid cohesion|double-strand break repair via nonhomologous end joining|transcription elongation from RNA polymerase II promoter|double-strand break repair via homologous recombination	DNA translocase activity	RSC complex
YPR101W	YPR101W	SNT309	hom	Verified	0.962191590726945	0.167976686255903	no	784	0.185732997870955	667	NA	FT	RNA PROCESSING	NUCLEUS		Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p	mRNA splicing, via spliceosome	first spliceosomal transesterification activity	Prp19 complex|U2-type catalytic step 1 spliceosome
YER097W_d	YER097W	YER097W	hom	Dubious	0.962137753012659	0.167990206055794	no	785	0.207476725400432	699	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL062W	YGL062W	PYC1	hom	Verified	0.961832066759595	0.168066983679695	no	786	0.158707147373138	544	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication	NADPH regeneration|gluconeogenesis	pyruvate carboxylase activity	cytosol
YOR049C	YOR049C	RSB1	hom	Verified	0.961812167900194	0.168071982355247	no	787	0.164455425709822	572	NA	FT	MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane	phospholipid translocation|fatty acid transport	phospholipid-translocating ATPase activity	integral to membrane|endoplasmic reticulum|plasma membrane
YBR081C	YBR081C	SPT7	hom	Verified	0.961004861613157	0.168274861698215	no	788	0.223853268995819	746	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION	HISTONE ACETYLTRANSFERASE	Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex	conjugation with cellular fusion|histone acetylation|protein complex assembly|chromatin modification	structural molecule activity	SLIK (SAGA-like) complex|mitochondrion|SAGA complex
YJL160C_p	YJL160C	YJL160C	hom	Uncharacterized	0.96083465045853	0.16831765655087	no	789	0.202040786363549	692	NA					Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YNL275W	YNL275W	BOR1	hom	Verified	0.960165492916324	0.168485965419133	no	790	0.163162712145022	553	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1	borate transport|protein targeting to vacuole	borate efflux transmembrane transporter activity	integral to membrane|plasma membrane|fungal-type vacuole
YNL077W	YNL077W	APJ1	hom	Verified	0.959019753060486	0.168774397123426	no	791	0.203598868559701	696	NA	FT		NUCLEUS|MITOCHONDRION		Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress	biological_process	unfolded protein binding	mitochondrion|nucleus|cytoplasm
YNR058W	YNR058W	BIO3	hom	Verified	0.958159018564536	0.16899128938695	no	792	0.178817208615067	639	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM			7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis	biotin biosynthetic process	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	cytoplasm
YFL044C	YFL044C	OTU1	hom	Verified	0.957764040613513	0.169090877843853	no	793	0.140237701092487	497	NA	FT	PROTEOLYSIS	NUCLEUS		Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress	protein deubiquitination|regulation of transcription, DNA-dependent	ubiquitin-specific protease activity	nucleus|cytoplasm
YFR049W	YFR049W	YMR31	hom	Verified	0.957512580930857	0.169154299702054	no	794	0.192040917432086	647	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36	cytoplasmic translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YNL014W	YNL014W	HEF3	hom	Verified	0.957455398120535	0.169168724185557	no	795	0.181618217239636	613	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication	translational elongation	ATPase activity|translation elongation factor activity	cytosolic ribosome
YKL011C	YKL011C	CCE1	hom	Verified	0.95685262009329	0.169320824243754	no	796	0.179496934199695	632	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA	mitochondrial genome maintenance	endodeoxyribonuclease activity	mitochondrial inner membrane
YER080W	YER080W	AIM9	hom	Verified	0.956268169375213	0.169468383529736	no	797	0.17762056752818	582	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YMR109W	YMR109W	MYO5	hom	Verified	0.955153563687809	0.169750022445487	no	798	0.152831521150002	542	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization	bipolar cellular bud site selection|endocytosis|exocytosis|fungal-type cell wall organization|response to salt stress|receptor-mediated endocytosis|actin cortical patch localization|response to osmotic stress	microfilament motor activity	mating projection tip|actin cortical patch
YLR040C_p	YLR040C	YLR040C	hom	Uncharacterized	0.952540897957634	0.170411367354732	no	799	0.176911553763765	598	NA					Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential	biological_process	molecular_function	fungal-type cell wall
YBR013C_p	YBR013C	YBR013C	hom	Uncharacterized	0.951730137378526	0.170616930494429	no	800	0.181853561811693	688	NA					Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein	biological_process	molecular_function	cellular_component
YBR156C	YBR156C	SLI15	hom	Verified	0.951573362392819	0.170656698094231	no	801	0.167541901452005	576	NA	FT	CELL DIVISION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON		Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly	chromosome segregation|protein phosphorylation|regulation of cytokinesis	protein kinase activator activity	spindle microtubule|spindle midzone|chromosome passenger complex|kinetochore microtubule
YJL136C	YJL136C	RPS21B	hom	Verified	0.951038527854602	0.170792409062343	no	802	0.178526045981508	590	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YCR036W	YCR036W	RBK1	hom	Verified	0.949949176809115	0.171069038712115	no	803	0.22145921407782	779	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Putative ribokinase	D-ribose metabolic process	ribokinase activity|ATP binding	nucleus|cytoplasm
YOR092W	YOR092W	ECM3	hom	Verified	0.949942432794374	0.171070752178351	no	804	0.163505977313871	510	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication	fungal-type cell wall organization	ATPase activity	integral to membrane|endoplasmic reticulum
YLR278C_p	YLR278C	YLR278C	hom	Uncharacterized	0.948961993816873	0.171319971200726	no	805	0.184950669259533	627	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene	biological_process	sequence-specific DNA binding	nucleus
YJR152W	YJR152W	DAL5	hom	Verified	0.948530783424881	0.171429654567436	no	806	0.167108971930634	524	NA	FT		PLASMA MEMBRANE		Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression	dipeptide transport|allantoate transport	dipeptide transporter activity|allantoate transmembrane transporter activity	integral to membrane|plasma membrane
YIR031C	YIR031C	DAL7	hom	Verified	0.948390323737667	0.171465391807342	no	807	0.175801142497214	646	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process	malate synthase activity	cellular_component
YKR101W	YKR101W	SIR1	hom	Verified	0.948097436913079	0.171539926486441	no	808	0.152220935952039	525	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin	establishment of chromatin silencing|chromatin silencing at silent mating-type cassette	chromatin binding|sequence-specific DNA binding	chromatin silencing complex
YGL218W_d	YGL218W	YGL218W	hom	Dubious	0.948021443815521	0.17155926881009	no	809	0.21370774702963	724	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YHR193C	YHR193C	EGD2	hom	Verified	0.947911617301742	0.171587225126635	no	810	0.171752159475504	603	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes	'de novo' cotranslational protein folding	unfolded protein binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding	nascent polypeptide-associated complex
YDL041W_d	YDL041W	YDL041W	hom	Dubious	0.946887443216622	0.171848068551742	no	811	0.208823717485433	734	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C	Unknown	Unknown	Unknown
YDR015C_d	YDR015C	YDR015C	hom	Dubious	0.945270866582502	0.172260303964014	no	812	0.157802133805461	540	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A	Unknown	Unknown	Unknown
YHR206W	YHR206W	SKN7	hom	Verified	0.945220746453261	0.172273094932796	no	813	0.20716152462827	709	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; SKN7 has a paralog, HMS2, that arose from the whole genome duplication	response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|transcription, DNA-dependent|response to osmotic stress|regulation of cell size	sequence-specific DNA binding|two-component response regulator activity|sequence-specific DNA binding transcription factor activity	nucleus
YGL057C	YGL057C	GEP7	hom	Verified	0.944557952186453	0.172442301144579	no	814	0.185291676380869	627	NA	FT		MITOCHONDRION		Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPR059C_d	YPR059C	YPR059C	hom	Dubious	0.9440762264817	0.172565348459792	no	815	0.186161285342792	686	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W	Unknown	Unknown	Unknown
YHR159W_p	YHR159W	TDA11	hom	Uncharacterized	0.943746899776574	0.172649500673716	no	816	0.195189545960926	653	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	cytoplasm
YLR324W	YLR324W	PEX30	hom	Verified	0.943628921222353	0.172679653868923	no	817	0.205678669500104	711	NA	FF|FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p	peroxisome organization	molecular_function	integral to membrane|peroxisome|integral to peroxisomal membrane
YHR117W	YHR117W	TOM71	hom	Verified	0.943109922044073	0.17281234058516	no	818	0.1583924628287	585	NA	FT		MITOCHONDRION		Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication	biological_process	protein transporter activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane
YLR443W	YLR443W	ECM7	hom	Verified	0.943045506745376	0.172828813456085	no	819	0.172830566031017	649	NA	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency	fungal-type cell wall organization|calcium ion transport	molecular_function	integral to membrane
YDL013W	YDL013W	SLX5	hom	Verified	0.942451552609729	0.172980752007746	no	820	0.223083133346537	790	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers	protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination	SUMO binding|ubiquitin-protein ligase activity	ubiquitin ligase complex|nucleus
YLR165C	YLR165C	PUS5	hom	Verified	0.94164198844423	0.173187982453874	no	821	0.180058817581461	632	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	MITOCHONDRION		Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability	rRNA modification|pseudouridine synthesis	pseudouridylate synthase activity	mitochondrion
YMR209C_p	YMR209C	YMR209C	hom	Uncharacterized	0.94050236729673	0.173479967969795	no	822	0.17452854474872	612	NA					Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YBR267W	YBR267W	REI1	hom	Verified	0.939426200315081	0.173755983173433	no	823	0.203898351637795	725	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION		RIBOSOME	Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network	ribosomal large subunit biogenesis|nucleocytoplasmic transport|mitotic cell cycle|budding cell bud growth	sequence-specific DNA binding	cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YLR311C_d	YLR311C	YLR311C	hom	Dubious	0.938657813838388	0.173953229699905	no	824	0.180432685250705	616	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR022C-A_p	YHR022C-A	YHR022C-A	hom	Uncharacterized	0.938329928352002	0.174037441959688	no	825	0.166796175356984	581	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YJR111C_p	YJR111C	YJR111C	hom	Uncharacterized	0.938300325678957	0.174045046218731	no	826	0.168164285912869	634	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria	biological_process	molecular_function	mitochondrion
YPR021C	YPR021C	AGC1	hom	Verified	0.938181751296881	0.174075507420603	no	827	0.181608016853696	652	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis	L-glutamate transport|aspartate transport|cellular nitrogen compound biosynthetic process	antiporter activity|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|uniporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YCR006C_d	YCR006C	YCR006C	hom	Dubious	0.937543128242975	0.174239624958746	no	828	0.18133208773663	637	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR315W	YOR315W	SFG1	hom	Verified	0.937461512818991	0.174260606109044	no	829	0.166357561266583	560	NA	FT	CELL CYCLE	NUCLEUS		Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate	mitotic cell cycle|pseudohyphal growth	molecular_function	nucleus|cytoplasm
YHL024W	YHL024W	RIM4	hom	Verified	0.935992124659145	0.174638621255436	no	830	0.195942402017922	647	NA	FT	CELL CYCLE			Putative RNA-binding protein required for the expression of early and middle sporulation genes	meiosis|reciprocal meiotic recombination|sporulation resulting in formation of a cellular spore|premeiotic DNA replication	RNA binding	cytoplasm
YLR102C	YLR102C	APC9	hom	Verified	0.935732854147883	0.174705375249295	no	831	0.161203069361723	580	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	chromatin assembly|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YGL129C	YGL129C	RSM23	hom	Verified	0.934918657504548	0.174915110545631	no	832	0.185520052987496	675	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YBR032W_d	YBR032W	YBR032W	hom	Dubious	0.932578674575731	0.175518774130969	no	833	0.14276454584784	509	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR388W	YLR388W	RPS29A	hom	Verified	0.931959604243136	0.175678701133944	no	834	0.222241807345902	769	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR036C	YDR036C	EHD3	hom	Verified	0.931768444230408	0.175728102942158	no	835	0.153612118817081	526	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis	fatty acid beta-oxidation|biological_process	3-hydroxyisobutyryl-CoA hydrolase activity	mitochondrion
YGR263C	YGR263C	SAY1	hom	Verified	0.931752569867285	0.175732205776638	no	836	0.185800187037827	606	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum	response to toxin|sterol metabolic process|sterol deacetylation	steryl deacetylase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YGR104C	YGR104C	SRB5	hom	Verified	0.931536302933879	0.17578810744561	no	837	0.188526608868704	667	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance	transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly	core mediator complex
YKL146W	YKL146W	AVT3	hom	Verified	0.93071299566807	0.176001022735437	no	838	0.177166123828337	610	NA	FT	VACUOLAR TRANSPORT			Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid export from vacuole	transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YIL057C	YIL057C	RGI2	hom	Verified	0.929927784405627	0.176204238085599	no	839	0.193210884180291	669	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose	energy reserve metabolic process	molecular_function	cytoplasm
YNL067W-B_p	YNL067W-B	YNL067W-B	hom	Uncharacterized	0.929231182339014	0.176384645332974	no	840	0.192968559194192	681	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL200W	YPL200W	CSM4	hom	Verified	0.928856196382212	0.176481808233265	no	841	0.178128184521007	618	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|CHROMOSOME		Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements	meiotic telomere clustering|meiotic chromosome segregation|synapsis|regulation of reciprocal meiotic recombination	molecular_function	nuclear chromosome, telomeric region|endoplasmic reticulum membrane
YDR017C	YDR017C	KCS1	hom	Verified	0.928704671635711	0.176521079529418	no	842	0.16430930755828	595	NA					Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance	inositol phosphate biosynthetic process	inositol heptakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol heptakisphosphate 5-kinase activity	cytoplasm
YGL241W	YGL241W	KAP114	hom	Verified	0.928586428373578	0.176551728964588	no	843	0.172807517332945	560	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress	protein import into nucleus|transcription factor import into nucleus	protein transporter activity	integral to membrane|nucleus|cytoplasm
YPL167C	YPL167C	REV3	hom	Verified	0.927965650421046	0.176712693926842	no	844	0.181015254189221	626	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair	error-prone translesion synthesis|error-free translesion synthesis	DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YNL101W	YNL101W	AVT4	hom	Verified	0.92777288469789	0.1767626960946	no	845	0.165957547064412	582	NA	FT	VACUOLAR TRANSPORT			Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid export from vacuole	transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YDR105C	YDR105C	TMS1	hom	Verified	0.927004562874895	0.176962082609445	no	846	0.185669354484531	636	NA					Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane|membrane
YBL071C-B_p	YBL071C-B	YBL071C-B	hom	Uncharacterized	0.926122106822835	0.177191263279263	no	847	0.1938031723408	656	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YNL168C_p	YNL168C	FMP41	hom	Uncharacterized	0.92567569089619	0.177307272324999	no	848	0.158872650571516	560	NA	FT		MITOCHONDRION		Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPR042C	YPR042C	PUF2	hom	Verified	0.925383826425944	0.177383144373622	no	849	0.193581867590343	696	NA					Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	mRNA binding	cytoplasm
YDR482C	YDR482C	CWC21	hom	Verified	0.925332802574479	0.177396410457062	no	850	0.195364715519674	664	NA	FT	RNA PROCESSING	NUCLEUS		Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YMR071C	YMR071C	TVP18	hom	Verified	0.92312684483124	0.177970553229566	no	851	0.212794115425267	737	NA	FF|FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments	vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|clathrin-coated vesicle
YGL064C	YGL064C	MRH4	hom	Verified	0.923070810679665	0.177985152434903	no	852	0.191036287991217	646	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	MITOCHONDRION		Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function	RNA metabolic process	RNA helicase activity	mitochondrion
YHR010W	YHR010W	RPL27A	hom	Verified	0.923035518588963	0.177994347866303	no	853	0.151648527887311	585	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YKL009W	YKL009W	MRT4	hom	Verified	0.92256351917079	0.178117357139244	no	854	0.192606235499149	642	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus	nuclear-transcribed mRNA catabolic process|ribosomal large subunit assembly|ribosomal large subunit biogenesis|rRNA processing	LSU rRNA binding	nucleoplasm|nucleolus|nucleus|preribosome, large subunit precursor
YML027W	YML027W	YOX1	hom	Verified	0.921899496106791	0.178290501009873	no	855	0.164464152011148	552	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS|CHROMOSOME		Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication	negative regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nuclear chromatin|nucleus
YGR067C_p	YGR067C	YGR067C	hom	Uncharacterized	0.92183212729602	0.178308073336994	no	856	0.159550359967023	524	NA	FT		NUCLEUS		Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p	biological_process	sequence-specific DNA binding	cellular_component
YDR348C	YDR348C	PAL1	hom	Verified	0.921798897768309	0.178316741253201	no	857	0.178807723437956	623	NA	FT		SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cell cortex|cellular bud neck|mating projection tip
YMR257C	YMR257C	PET111	hom	Verified	0.921787145714655	0.178319806837796	no	858	0.200400986901112	710	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrion|mitochondrial inner membrane
YDR214W	YDR214W	AHA1	hom	Verified	0.920973877951103	0.178532032647224	no	859	0.189687010339679	628	NA	FT	NUCLEOTIDE METABOLISM			Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress	protein folding|response to stress	ATPase activator activity|chaperone binding	cytoplasm
YDL073W_p	YDL073W	YDL073W	hom	Uncharacterized	0.919476848927932	0.178923104716939	no	860	0.211235905337459	776	NA					Putative protein of unknown function; YDL073W is not an essential gene	biological_process	molecular_function	cellular_component
YGL031C	YGL031C	RPL24A	hom	Verified	0.919201431482999	0.178995111272708	no	861	0.188898600128622	674	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YPL068C_p	YPL068C	YPL068C	hom	Uncharacterized	0.919143477217833	0.179010265456235	no	862	0.181456304451025	599	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus
YPL058C	YPL058C	PDR12	hom	Verified	0.919034655963107	0.179038722786504	no	863	0.180270850729012	621	NA	FT	KETONE METABOLISM|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity	propionate metabolic process|transport|organic acid transport	xenobiotic-transporting ATPase activity|organic acid transmembrane transporter activity	integral to membrane|plasma membrane
YLR297W	YLR297W	YLR297W	hom	Verified	0.918489760680137	0.179181258573074	no	864	0.170896363508156	597	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication	biological_process	molecular_function	fungal-type vacuole
YIL060W_p	YIL060W	YIL060W	hom	Uncharacterized	0.917854233893075	0.179347592237357	no	865	0.202171790038901	723	NA					Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene	biological_process	molecular_function	cellular_component
YGR226C_d	YGR226C	YGR226C	hom	Dubious	0.917314275729719	0.179488989400953	no	866	0.184432553873787	601	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W	Unknown	Unknown	Unknown
YDR494W	YDR494W	RSM28	hom	Verified	0.917144216513659	0.179533536784781	no	867	0.184459497985197	671	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation	cytoplasmic translation|translational initiation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YJR001W	YJR001W	AVT1	hom	Verified	0.916939269579681	0.179587232315663	no	868	0.217501907347815	746	NA	FT	VACUOLAR TRANSPORT			Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid transport|vacuolar transport	transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YHR009C_p	YHR009C	TDA3	hom	Uncharacterized	0.916268721839389	0.179762984493545	no	869	0.188636359962878	661	NA	FT	VESICLE-MEDIATED TRANSPORT|OXIDATION-REDUCTION PROCESS			Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1	retrograde transport, endosome to Golgi	molecular_function	late endosome|cytoplasm
YHR086W	YHR086W	NAM8	hom	Verified	0.915614227470704	0.179934633211811	no	870	0.179669464217641	590	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS|MITOCHONDRION		RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function	mRNA splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|mRNA splice site selection	mRNA binding|RNA binding	commitment complex|U1 snRNP|U2-type prespliceosome
YPR072W	YPR072W	NOT5	hom	Verified	0.914549737806908	0.180214027699078	no	871	0.180747924280035	609	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation	deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination	ubiquitin-protein ligase activity	CCR4-NOT core complex|cytoplasm
YGR118W	YGR118W	RPS23A	hom	Verified	0.913433216778581	0.180507371162679	no	872	0.190786855099609	644	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity	structural constituent of ribosome	cytosolic small ribosomal subunit
YCR043C_p	YCR043C	YCR043C	hom	Uncharacterized	0.91331394665459	0.180538724687242	no	873	0.195831743585797	718	NA	FT		GOLGI APPARATUS|SITE OF POLARIZED GROWTH		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene	biological_process	molecular_function	Golgi apparatus|mating projection tip
YPR172W_p	YPR172W	YPR172W	hom	Uncharacterized	0.913133724440523	0.180586107671945	no	874	0.175220901316065	651	NA	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	NUCLEUS		Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YAR020C	YAR020C	PAU7	hom	Verified	0.912790910550742	0.180676259846773	no	875	0.180945612301497	596	NA					Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YBR204C	YBR204C	LDH1	hom	Verified	0.912594605964884	0.180727896145741	no	876	0.174645886496392	577	NA	FT	LIPID METABOLISM			Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)	lipid homeostasis	hydrolase activity, acting on ester bonds|serine hydrolase activity|triglyceride lipase activity	lipid particle
YDR306C_p	YDR306C	YDR306C	hom	Uncharacterized	0.911538457818168	0.181005865959601	no	877	0.19885643424825	642	NA	FT	PROTEOLYSIS			F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YGL198W	YGL198W	YIP4	hom	Verified	0.91051435165812	0.181275658252247	no	878	0.195537182075923	644	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YNL248C	YNL248C	RPA49	hom	Verified	0.90839248860026	0.181835446428394	no	879	0.171795653998562	583	NA	FT		NUCLEUS		RNA polymerase I subunit A49	transcription elongation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size	molecular_function	DNA-directed RNA polymerase I complex
YJL158C	YJL158C	CIS3	hom	Verified	0.90836652602026	0.181842302544203	no	880	0.163878217184782	552	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family	fungal-type cell wall organization	structural constituent of cell wall	extracellular region|fungal-type cell wall|endoplasmic reticulum|plasma membrane|cellular bud tip
YLR270W	YLR270W	DCS1	hom	Verified	0.907170782299299	0.182158245956642	no	881	0.197216466619738	663	NA	FT		NUCLEUS|MITOCHONDRION		Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of nuclease activity|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|enzyme activator activity|m7G(5')pppN diphosphatase activity	mitochondrion|nucleus|cytoplasmic mRNA processing body|cytoplasm
YIR003W	YIR003W	AIM21	hom	Verified	0.9070952982156	0.182178202121529	no	882	0.16107560934385	554	NA	FT		SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton	mitochondrion migration along actin filament	molecular_function	ribosome|mating projection tip|actin cytoskeleton
YHR039C	YHR039C	MSC7	hom	Verified	0.906295085573009	0.182389843000704	no	883	0.204467769936509	707	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM		Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids	reciprocal meiotic recombination	molecular_function	integral to membrane|endoplasmic reticulum
YDR253C	YDR253C	MET32	hom	Verified	0.906223132863659	0.182408880634931	no	884	0.204862675359409	712	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication	regulation of mitotic cell cycle|regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YCR009C	YCR009C	RVS161	hom	Verified	0.906007379870908	0.182465973162294	no	885	0.196706579264807	717	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	SITE OF POLARIZED GROWTH|CYTOSKELETON		Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress	conjugation with cellular fusion|actin cytoskeleton reorganization|endocytosis|actin cortical patch localization|response to starvation|response to osmotic stress|lipid tube assembly|actin cytoskeleton organization	cytoskeletal protein binding|lipid binding	membrane raft|mating projection tip|mating projection|actin cortical patch
YBR146W	YBR146W	MRPS9	hom	Verified	0.905586228311525	0.182577450387049	no	886	0.194528632205126	668	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YIL107C	YIL107C	PFK26	hom	Verified	0.905465600319023	0.182609387994858	no	887	0.192723039245535	665	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YLL059C_d	YLL059C	YLL059C	hom	Dubious	0.903945261053703	0.183012213823269	no	888	0.20653489027369	693	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR101C	YMR101C	SRT1	hom	Verified	0.903697506716689	0.183077910779624	no	889	0.158376576501286	507	NA	FT	CARBOHYDRATE METABOLISM			Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase	protein glycosylation	dehydrodolichyl diphosphate synthase activity|prenyltransferase activity	lipid particle
YKL091C	YKL091C	YKL091C	hom	Verified	0.903108483454397	0.183234160993246	no	890	0.187935083975452	660	NA	FT		NUCLEUS		Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study	biological_process	phosphatidylcholine binding|phosphatidylinositol transporter activity|phosphatidylinositol binding|phosphatidylcholine transporter activity	nucleus
YOR058C	YOR058C	ASE1	hom	Verified	0.902983160473255	0.183267416149901	no	891	0.14916329606679	531	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress	cytokinesis, completion of separation|mitotic anaphase B|microtubule bundle formation|spindle pole body separation|spindle midzone assembly|mitotic spindle stabilization|mitotic spindle elongation	microtubule binding	spindle midzone|nuclear microtubule|spindle
YNL268W	YNL268W	LYP1	hom	Verified	0.902675292541768	0.183349126612682	no	892	0.191323981019585	673	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids	basic amino acid transport	basic amino acid transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YJL060W	YJL060W	BNA3	hom	Verified	0.901151524909062	0.183753880340615	no	893	0.182330832696257	628	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate	kynurenic acid biosynthetic process	arylformamidase activity|kynurenine-oxoglutarate transaminase activity	mitochondrion|cytoplasm
YLR313C	YLR313C	SPH1	hom	Verified	0.900223519523555	0.184000656080817	no	894	0.204739897338481	718	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p	bipolar cellular bud site selection|pseudohyphal growth|invasive filamentous growth|mating projection assembly	molecular_function	incipient cellular bud site|cellular bud neck|cellular bud tip|mating projection
YOR080W	YOR080W	DIA2	hom	Verified	0.899947096780073	0.184074202448371	no	895	0.193367827558851	677	NA	FT	CELL CYCLE|PROTEOLYSIS	NUCLEUS|CHROMOSOME	UBIQUITIN LIGASE COMPLEX	Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA replication|invasive growth in response to glucose limitation|protein ubiquitination	ubiquitin-protein ligase activity|DNA replication origin binding	SCF ubiquitin ligase complex|nucleus|nuclear replication fork
YIL161W_p	YIL161W	YIL161W	hom	Uncharacterized	0.899946467794878	0.18407436982007	no	896	0.161175870110181	574	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene	biological_process	molecular_function	cytoplasm
YPL029W	YPL029W	SUV3	hom	Verified	0.899441151240959	0.184208864152711	no	897	0.244858796727382	828	NA	FF|FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION|CHROMOSOME		ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron	mitochondrial DNA replication|mitochondrial RNA catabolic process|Group I intron splicing	exoribonuclease II activity|ATP-dependent RNA helicase activity	mitochondrion|mitochondrial chromosome|mitochondrial degradosome
YOL159C	YOL159C	YOL159C	hom	Verified	0.899271743975212	0.184253967033904	no	898	0.15816527690813	543	NA					Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA	biological_process	molecular_function	cellular_component
YFR053C	YFR053C	HXK1	hom	Verified	0.899119664423761	0.184294462448917	no	899	0.204147079220321	709	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication	mannose metabolic process|glucose import|glycolysis|fructose import|glucose metabolic process|fructose metabolic process	hexokinase activity	cytosol|mitochondrion|cytoplasm
YKR034W	YKR034W	DAL80	hom	Verified	0.898710095823357	0.18440354903081	no	900	0.182084600025334	643	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication	nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YDR034W-B_p	YDR034W-B	YDR034W-B	hom	Uncharacterized	0.898264316424702	0.184522325823869	no	901	0.190447481449683	627	NA					Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YJL149W	YJL149W	DAS1	hom	Verified	0.89801290648424	0.184589334346811	no	902	0.198269123809065	699	NA	FT	PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YOR044W	YOR044W	IRC23	hom	Verified	0.896449810900125	0.185006287083562	no	903	0.17555541358698	610	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication	biological_process	molecular_function	endoplasmic reticulum
YDR179C	YDR179C	CSN9	hom	Verified	0.896264482464772	0.185055761860188	no	904	0.180825652469449	580	NA	FT	SIGNALING	NUCLEUS		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	molecular_function	signalosome
YGR174W-A_p	YGR174W-A	YGR174W-A	hom	Uncharacterized	0.895875373196827	0.185159664157266	no	905	0.15764479742391	535	NA					Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YBR200W	YBR200W	BEM1	hom	Verified	0.895617461639763	0.185228553216136	no	906	0.16207537138377	585	NA	FT		SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p	establishment of cell polarity|cell morphogenesis involved in conjugation with cellular fusion	protein complex scaffold|phosphatidylinositol-3-phosphate binding	incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip
YNL283C	YNL283C	WSC2	hom	Verified	0.89488007860391	0.185425598537956	no	907	0.218409871081941	765	NA	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response	fungal-type cell wall organization|response to heat|Rho protein signal transduction	transmembrane signaling receptor activity	site of polarized growth|cellular bud|mating projection tip|cytoplasm
YJL215C_d	YJL215C	YJL215C	hom	Dubious	0.894825069423626	0.185440303441134	no	908	0.199997016337304	654	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR027C	YCR027C	RHB1	hom	Verified	0.894206794214671	0.185605628860097	no	909	0.189219489191469	652	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins	lysine transport|retrograde transport, endosome to Golgi|arginine transport	GTPase activity	extrinsic to plasma membrane
YKL157W	YKL157W	APE2	hom	Verified	0.893148218127433	0.185888902026672	no	910	0.194217000265282	619	NA	FT	PROTEOLYSIS	MITOCHONDRION		Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication	peptide catabolic process	metalloaminopeptidase activity	mitochondrion|extracellular region|cell wall-bounded periplasmic space
YDR350C	YDR350C	ATP22	hom	Verified	0.892989114588605	0.185931501028556	no	911	0.195097317149648	655	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane	proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrial inner membrane
YNL022C_p	YNL022C	YNL022C	hom	Uncharacterized	0.892105238940512	0.186168263548204	no	912	0.170749173828	620	NA	FT		NUCLEUS		Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis	biological_process	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YPR188C	YPR188C	MLC2	hom	Verified	0.891112249746592	0.186434476927125	no	913	0.180811487015746	602	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring	actomyosin contractile ring contraction	myosin II binding	cellular bud neck contractile ring
YLR027C	YLR027C	AAT2	hom	Verified	0.890731998272002	0.186536482062529	no	914	0.235735433771674	784	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells	aspartate biosynthetic process	L-aspartate:2-oxoglutarate aminotransferase activity	cytosol|peroxisome
YOR108W	YOR108W	LEU9	hom	Verified	0.889295471229256	0.186922152389211	no	915	0.174694172116876	604	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication	leucine biosynthetic process	2-isopropylmalate synthase activity	mitochondrion
YGL094C	YGL094C	PAN2	hom	Verified	0.889042745243411	0.186990053775882	no	916	0.199725671039923	684	NA	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEOLYSIS			Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes	mRNA 3'-end processing|postreplication repair|mRNA processing	poly(A)-specific ribonuclease activity	PAN complex|cytoplasm
YHR097C_p	YHR097C	YHR097C	hom	Uncharacterized	0.887229726698718	0.18747761549731	no	917	0.182244765934022	637	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YGR219W_d	YGR219W	YGR219W	hom	Dubious	0.886893668894467	0.187568075285229	no	918	0.212076133824699	665	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C	Unknown	Unknown	Unknown
YBR048W	YBR048W	RPS11B	hom	Verified	0.886863208948707	0.187576275803457	no	919	0.198020521886712	690	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YKL067W	YKL067W	YNK1	hom	Verified	0.886351636595017	0.187714035953898	no	920	0.154415985546642	528	NA	FT	RESPONSE TO DNA DAMAGE|NUCLEOTIDE METABOLISM	MITOCHONDRION		Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress	nucleoside diphosphate phosphorylation|nucleoside triphosphate biosynthetic process|response to DNA damage stimulus	nucleoside diphosphate kinase activity	cytosol|mitochondrion|mitochondrial intermembrane space
YHR167W	YHR167W	THP2	hom	Verified	0.885817238576512	0.187858009498305	no	921	0.203758349386946	718	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION	NUCLEUS		Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance	mRNA export from nucleus|transcription elongation from RNA polymerase II promoter|DNA recombination	nucleic acid binding	THO complex part of transcription export complex|nucleoplasmic THO complex
YLR445W	YLR445W	GMC2	hom	Verified	0.885043233353813	0.188066657103899	no	922	0.188054997125405	657	NA	FT	CELL CYCLE			Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor	meiosis|synaptonemal complex organization	molecular_function	cellular_component
YDR433W_d	YDR433W	YDR433W	hom	Dubious	0.8848780928309	0.188111192333144	no	923	0.205838194254197	718	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL065C	YJL065C	DLS1	hom	Verified	0.884541224629304	0.188202059400144	no	924	0.218186606139429	734	NA	FT	GENE SILENCING	NUCLEUS		Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication	chromatin silencing at telomere	molecular_function	chromatin accessibility complex|nucleus
YPR131C	YPR131C	NAT3	hom	Verified	0.883097379963177	0.188591829824368	no	925	0.1868839395076	633	NA	FT	MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION			Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met	mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization	peptide alpha-N-acetyltransferase activity	NatB complex|cytoplasm
YMR160W	YMR160W	YMR160W	hom	Verified	0.883062460452181	0.188601262616294	no	926	0.186106914688008	652	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress	biological_process	molecular_function	fungal-type vacuole membrane
YLR220W	YLR220W	CCC1	hom	Verified	0.881979593414522	0.188893921362558	no	927	0.179212835817067	624	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress	manganese ion transport|cellular calcium ion homeostasis|cellular iron ion homeostasis|cellular manganese ion homeostasis|ferrous iron transport	manganese ion transmembrane transporter activity|ferrous iron transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|Golgi apparatus
YML121W	YML121W	GTR1	hom	Verified	0.881804347513155	0.188941310113613	no	928	0.2329960693446	800	NA	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|GENE SILENCING	NUCLEUS		Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB	phosphate ion transport|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|chromatin silencing at telomere	GDP binding|GTP binding	fungal-type vacuole membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YBR185C	YBR185C	MBA1	hom	Verified	0.881241737324315	0.189093496657815	no	929	0.188024716754204	620	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane	protein insertion into mitochondrial membrane from inner side|mitochondrial respiratory chain complex III biogenesis|inner mitochondrial membrane organization|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	ribosome binding	mitochondrion|mitochondrial inner membrane
YBL037W	YBL037W	APL3	hom	Verified	0.880976055083016	0.189165390170646	no	930	0.184992399902249	620	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YLR047C	YLR047C	FRE8	hom	Verified	0.879920939629052	0.189451070127734	no	931	0.217332583031761	751	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p	cellular metal ion homeostasis	oxidoreductase activity, oxidizing metal ions	integral to membrane|membrane
YHR082C	YHR082C	KSP1	hom	Verified	0.879409540103848	0.189589630638583	no	932	0.194194739556912	664	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress	TOR signaling cascade|protein phosphorylation|Unknown|cellular protein localization|regulation of filamentous growth|negative regulation of macroautophagy	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YBR293W	YBR293W	VBA2	hom	Verified	0.878842874050466	0.189743238066577	no	933	0.188424732916185	672	NA					Permease of basic amino acids in the vacuolar membrane	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity|drug transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YEL013W	YEL013W	VAC8	hom	Verified	0.877701033102336	0.190052991854013	no	934	0.174867284879907	635	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions	piecemeal microautophagy of nucleus|vacuole inheritance|CVT vesicle assembly|vacuole fusion, non-autophagic|macroautophagy|nucleus-vacuole junction assembly	protein anchor	fungal-type vacuole membrane|nucleus-vacuole junction|Myo2p-Vac17p-Vac8p transport complex
YPL079W	YPL079W	RPL21B	hom	Verified	0.877217036634177	0.190184382103057	no	935	0.179451362763174	642	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOR120W	YOR120W	GCY1	hom	Verified	0.8768654450835	0.190279863452152	no	936	0.228115492238198	749	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication	cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process	oxidoreductase activity|mRNA binding|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity	nucleus|cytoplasm
YDL107W	YDL107W	MSS2	hom	Verified	0.876676358982591	0.190331225541079	no	937	0.192686021897705	679	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p	protein insertion into mitochondrial membrane from inner side	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrial matrix
YHL029C_p	YHL029C	OCA5	hom	Uncharacterized	0.874938930207575	0.19080356763869	no	938	0.219278827862902	772	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts	biological_process	molecular_function	cytoplasm
YJL189W	YJL189W	RPL39	hom	Verified	0.874508706428263	0.190920640451875	no	939	0.191424434131257	644	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YPL156C	YPL156C	PRM4	hom	Verified	0.873524286860542	0.191188687156199	no	940	0.163589548248411	608	NA					Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift	biological_process	molecular_function	integral to membrane
YKR056W	YKR056W	TRM2	hom	Verified	0.873083368141855	0.191308819286683	no	941	0.183182942930326	670	NA	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE			tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair	double-strand break repair|DNA repair|tRNA modification	tRNA (m5U54) methyltransferase activity|double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity	cellular_component
YHR161C	YHR161C	YAP1801	hom	Verified	0.871918434385351	0.191626438125871	no	942	0.193814041181662	729	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication	endocytosis	clathrin binding	actin cortical patch
YNL206C	YNL206C	RTT106	hom	Verified	0.871241709203886	0.191811095265471	no	943	0.2067876810321	725	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition	DNA replication-independent nucleosome assembly|negative regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|DNA replication-dependent nucleosome assembly|heterochromatin assembly involved in chromatin silencing	double-stranded DNA binding|histone binding	nucleus
YNL142W	YNL142W	MEP2	hom	Verified	0.870823353054093	0.191925306050505	no	944	0.180808605615036	596	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation	nitrogen utilization|ammonium transport|pseudohyphal growth	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YDL062W_d	YDL062W	YDL062W	hom	Dubious	0.870351498968967	0.192054171653947	no	945	0.19769828793322	656	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential	Unknown	Unknown	Unknown
YLL007C_p	YLL007C	YLL007C	hom	Uncharacterized	0.868128251217775	0.192662063385505	no	946	0.223526073589984	797	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene	biological_process	molecular_function	cytoplasm
YML131W	YML131W	YML131W	hom	Verified	0.868021853053677	0.19269118476633	no	947	0.163272557818026	543	NA	FT	OXIDATION-REDUCTION PROCESS			Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cytoplasm
YER116C	YER116C	SLX8	hom	Verified	0.867791371358545	0.1927542772704	no	948	0.163505389261022	578	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress	protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination	ubiquitin-protein ligase activity	ubiquitin ligase complex|nucleus
YDR245W	YDR245W	MNN10	hom	Verified	0.867453746113271	0.192846722240716	no	949	0.199587303242108	695	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family	N-glycan processing|cell wall mannoprotein biosynthetic process|substituted mannan metabolic process|barrier septum assembly	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YMR038C	YMR038C	CCS1	hom	Verified	0.8663160400671	0.193158436215039	no	950	0.268584449138491	926	NA	FF|FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress	intracellular copper ion transport	superoxide dismutase copper chaperone activity	cytosol|mitochondrial inner membrane|nucleus
YKL037W	YKL037W	AIM26	hom	Verified	0.865817342351649	0.193295168629795	no	951	0.238663225492268	833	NA	FF|FT		MITOCHONDRION		Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT	mitochondrion degradation	molecular_function	mitochondrion|integral to membrane
YMR085W_p	YMR085W	YMR085W	hom	Uncharacterized	0.865325543216359	0.193430067430714	no	952	0.203195197232506	710	NA	FT	CARBOHYDRATE METABOLISM			Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1	biological_process	molecular_function	cellular_component
YGL019W	YGL019W	CKB1	hom	Verified	0.865143990241844	0.193479881295139	no	953	0.232906251240634	785	NA	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases	regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein kinase regulator activity|protein serine/threonine kinase inhibitor activity	protein kinase CK2 complex|UTP-C complex
YGL261C_p	YGL261C	PAU11	hom	Uncharacterized	0.864119610848743	0.193761093515969	no	954	0.192343160002733	656	NA					Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2	biological_process	molecular_function	cellular_component
YJL127C	YJL127C	SPT10	hom	Verified	0.863094640641611	0.1940427171777	no	955	0.194527522478981	677	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS		Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box	DNA repair|negative regulation of transcription from RNA polymerase II promoter|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	histone acetyltransferase activity|sequence-specific DNA binding	nucleus
YPR054W	YPR054W	SMK1	hom	Verified	0.863033100203907	0.194059634131913	no	956	0.164273413073354	636	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p	ascospore wall assembly|protein phosphorylation|negative regulation of sporulation resulting in formation of a cellular spore	MAP kinase activity	mitochondrion
YMR311C	YMR311C	GLC8	hom	Verified	0.862988441737965	0.194071910935167	no	957	0.206534571940021	723	NA	FT	SIGNALING|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION	NUCLEUS		Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress	chromosome segregation|glycogen biosynthetic process	enzyme activator activity	nucleus|cytoplasm
YLR135W	YLR135W	SLX4	hom	Verified	0.862621797230132	0.194172720966046	no	958	0.178668788010255	588	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress	double-strand break repair via single-strand annealing, removal of nonhomologous ends|DNA replication|response to DNA damage stimulus|DNA-dependent DNA replication	5'-flap endonuclease activity	Slx1-Slx4 complex|nucleus
YJL154C	YJL154C	VPS35	hom	Verified	0.862511466187548	0.194203063066256	no	959	0.235367482765267	826	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YOR258W	YOR258W	HNT3	hom	Verified	0.860357700360527	0.19479594767003	no	960	0.22746535180303	791	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress	response to DNA damage stimulus	DNA 5'-adenosine monophosphate hydrolase activity	nucleus|cytoplasm
YPR111W	YPR111W	DBF20	hom	Verified	0.858775716607259	0.19523213371236	no	961	0.16569913718603	577	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs	cytokinesis after mitosis|protein phosphorylation|barrier septum assembly involved in cell cycle cytokinesis|regulation of mRNA catabolic process|exit from mitosis	protein serine/threonine kinase activity	spindle pole body|cellular bud neck|cytoplasm
YOR227W	YOR227W	HER1	hom	Verified	0.856465377180386	0.195870207950634	no	962	0.204545658243686	687	NA	FT		MITOCHONDRION		Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication	endoplasmic reticulum organization	molecular_function	mitochondrion|ribosome|cytoplasm
YMR153W	YMR153W	NUP53	hom	Verified	0.855643680406278	0.196097450562207	no	963	0.183999423947777	647	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication	positive regulation of transcription, DNA-dependent|NLS-bearing substrate import into nucleus|regulation of protein desumoylation|nuclear pore organization|protein import into nucleus|regulation of mitosis|mitotic cell cycle spindle assembly checkpoint	nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding	nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YDL061C	YDL061C	RPS29B	hom	Verified	0.85460706313582	0.196384358049634	no	964	0.181843860544226	609	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YGL246C	YGL246C	RAI1	hom	Verified	0.852735529808982	0.196902991525117	no	965	0.195850671964239	631	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z	deadenylation-dependent decapping of nuclear-transcribed mRNA|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|termination of RNA polymerase II transcription, poly(A)-coupled|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	enzyme regulator activity|m7G(5')pppN diphosphatase activity	nucleus
YBL100W-C_p	YBL100W-C	YBL100W-C	hom	Uncharacterized	0.850735039697977	0.197458277032056	no	966	0.19432151665587	671	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YLR299W	YLR299W	ECM38	hom	Verified	0.847481550014404	0.198363383285201	no	967	0.178809789113853	588	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation	xenobiotic metabolic process|glutathione catabolic process	gamma-glutamyltransferase activity	fungal-type vacuole
YKR035W-A	YKR035W-A	DID2	hom	Verified	0.847333233468515	0.198404703863347	no	968	0.19873658581568	680	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors	late endosome to vacuole transport via multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole	molecular_function	late endosome|cytoplasm
YOR014W	YOR014W	RTS1	hom	Verified	0.846767656812979	0.198562319607936	no	969	0.228517617501199	827	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON		B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A	mitotic cell cycle spindle orientation checkpoint|cellular protein localization|meiotic sister chromatid cohesion, centromeric|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|spindle pole body|condensed nuclear chromosome, centromeric region|cellular bud neck|cytoplasm
YJL093C	YJL093C	TOK1	hom	Verified	0.845853229224601	0.198817313363524	no	970	0.200661205841524	689	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin	cellular potassium ion homeostasis	potassium channel activity	integral to membrane|plasma membrane
YEL061C	YEL061C	CIN8	hom	Verified	0.845641760507401	0.19887631080818	no	971	0.21187055421759	759	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation	mitotic anaphase B|microtubule depolymerization|spindle pole body separation|mitotic spindle organization in nucleus|mitotic sister chromatid segregation	plus-end-directed microtubule motor activity|minus-end-directed microtubule motor activity	spindle microtubule|kinesin complex|mitochondrion|condensed nuclear chromosome kinetochore|kinetochore microtubule|astral microtubule
YML110C	YML110C	COQ5	hom	Verified	0.845468134221796	0.19892475851893	no	972	0.226009876070879	748	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes	ubiquinone biosynthetic process|aerobic respiration	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	mitochondrion|mitochondrial matrix
YGR201C_p	YGR201C	YGR201C	hom	Uncharacterized	0.844572605137885	0.199174754900359	no	973	0.176400240070076	607	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR219W	YMR219W	ESC1	hom	Verified	0.844519520157043	0.199189580071403	no	974	0.214654777964995	727	NA	FT	GENE SILENCING	NUCLEUS		Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p	chromatin silencing at telomere	molecular_function	nuclear periphery
YOL126C	YOL126C	MDH2	hom	Verified	0.844148695380949	0.199293159741065	no	975	0.193931206005573	668	NA	FT	PROTEIN LOCALIZATION|KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|PEROXISOME ORGANIZATION			Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1	protein import into peroxisome matrix|gluconeogenesis|malate metabolic process	L-malate dehydrogenase activity	cytosol|cytoplasm
YGR285C	YGR285C	ZUO1	hom	Verified	0.843981251099813	0.199339941308772	no	976	0.198746805450338	691	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS|MITOCHONDRION	RIBOSOME	Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p	protein folding|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity	unfolded protein binding	mitochondrion|ribosome|nucleolus|polysome|cytoplasm
YLL006W	YLL006W	MMM1	hom	Verified	0.843935326992866	0.199352773011122	no	977	0.242450616566752	822	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth	mitochondrion organization|mitochondrial genome maintenance|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrion|integral to endoplasmic reticulum membrane|ERMES complex
YBR279W	YBR279W	PAF1	hom	Verified	0.842817623684253	0.199665224978751	no	978	0.277924859256918	979	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1	negative regulation of DNA recombination|mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of transcription-coupled nucleotide-excision repair|rRNA processing|transcription elongation from RNA polymerase I promoter|regulation of chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin silencing at rDNA|Unknown|snoRNA 3'-end processing|transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity	transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YLR330W	YLR330W	CHS5	hom	Verified	0.842554107013215	0.199738933496502	no	979	0.24894890916464	854	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	GOLGI APPARATUS|SITE OF POLARIZED GROWTH		Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane	ascospore wall assembly|conjugation with cellular fusion|cell wall chitin catabolic process|Golgi to plasma membrane transport|cellular bud site selection|regulation of transcription, DNA-dependent	molecular_function	mating projection tip|cytoplasm|exomer complex
YJL208C	YJL208C	NUC1	hom	Verified	0.842505025810818	0.199752663858019	no	980	0.200133029074086	670	NA	FT		NUCLEUS|MITOCHONDRION		Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy	DNA catabolic process|RNA catabolic process|apoptotic process|DNA recombination	ribonuclease activity|endodeoxyribonuclease activity|exodeoxyribonuclease activity	mitochondrion|mitochondrial inner membrane|nucleus
YGL263W	YGL263W	COS12	hom	Verified	0.84102807655516	0.200166102824995	no	981	0.169101403767166	572	NA					Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	integral to membrane
YNR004W_p	YNR004W	SWM2	hom	Uncharacterized	0.840280698384017	0.20037551048335	no	982	0.191406639926111	670	NA	FT		NUCLEUS		Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds	biological_process	molecular_function	nucleolus
YOR243C	YOR243C	PUS7	hom	Verified	0.84000149853927	0.200453773154504	no	983	0.222884927349437	743	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria	snRNA pseudouridine synthesis|tRNA pseudouridine synthesis|enzyme-directed rRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus
YIL134C-A_p	YIL134C-A	YIL134C-A	hom	Uncharacterized	0.838763556466099	0.200801002533347	no	984	0.191863774656177	673	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YBR067C	YBR067C	TIP1	hom	Verified	0.838517993151328	0.200869923270457	no	985	0.194957283582042	673	NA	FT	CELL WALL ORG/BIOGENESIS			Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins	fungal-type cell wall organization	structural constituent of cell wall|lipase activity	fungal-type cell wall
YIR032C	YIR032C	DAL3	hom	Verified	0.838192641171371	0.200961259658065	no	986	0.206291344941715	697	NA	FT		PLASMA MEMBRANE		Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression	allantoin catabolic process	ureidoglycolate hydrolase activity	membrane
YPL096C-A	YPL096C-A	ERI1	hom	Verified	0.837635690718386	0.201117670738257	no	987	0.237047023679945	814	NA	FT	LIPID METABOLISM|SIGNALING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein	GPI anchor biosynthetic process|Ras protein signal transduction	GTPase inhibitor activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane
YOR053W_d	YOR053W	YOR053W	hom	Dubious	0.83514110865745	0.201819131592345	no	988	0.188434949186695	685	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C	Unknown	Unknown	Unknown
YCL058C	YCL058C	FYV5	hom	Verified	0.83441023893769	0.202024924728163	no	989	0.192922975779279	643	NA	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS			Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis	pheromone-dependent signal transduction involved in conjugation with cellular fusion|cellular ion homeostasis	molecular_function	integral to membrane
YAL028W	YAL028W	FRT2	hom	Verified	0.834104773529601	0.202110972722475	no	990	0.158180968934002	521	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication	response to stress	molecular_function	endoplasmic reticulum
YOL091W	YOL091W	SPO21	hom	Verified	0.833342039835392	0.202325926506224	no	991	0.186514718949245	634	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION	CYTOSKELETON		Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation	ascospore wall assembly|meiosis	structural molecule activity	spindle pole body
YDR357C_p	YDR357C	CNL1	hom	Uncharacterized	0.833166371409348	0.202375452787129	no	992	0.187644272755893	623	NA					Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	BLOC-1 complex|cytoplasm
YKR003W	YKR003W	OSH6	hom	Verified	0.832600470924016	0.202535046662252	no	993	0.180051489240566	667	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion	sterol homeostasis|maintenance of cell polarity|endocytosis|sterol transport|exocytosis|sterol metabolic process	phosphatidic acid binding|lipid binding|phosphatidylinositol-3,4-bisphosphate binding|oxysterol binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-4-phosphate binding	cortical endoplasmic reticulum|extrinsic to membrane|cytoplasm
YDR309C	YDR309C	GIC2	hom	Verified	0.832580590105844	0.202540654769799	no	994	0.184468566076166	639	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region	regulation of exit from mitosis|establishment of cell polarity|axial cellular bud site selection|Rho protein signal transduction	Rho GTPase binding|Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding	incipient cellular bud site|actin cap|plasma membrane|mating projection tip|cellular bud tip
YGL188C-A_p	YGL188C-A	YGL188C-A	hom	Uncharacterized	0.83240061098444	0.202591428648236	no	995	0.21483455483824	755	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNR051C	YNR051C	BRE5	hom	Verified	0.832318348501464	0.202614638236065	no	996	0.202035148622999	712	NA	FT	VESICLE-MEDIATED TRANSPORT			Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown	molecular_function	cytoplasm
YHR104W	YHR104W	GRE3	hom	Verified	0.830627862475732	0.203091944822477	no	997	0.200636372989949	697	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress	galactose catabolic process|cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process|response to stress	D-xylose:NADP reductase activity|mRNA binding|glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity	nucleus|cytoplasm
YBR182C-A_p	YBR182C-A	YBR182C-A	hom	Uncharacterized	0.829446697616099	0.203425843272631	no	998	0.213740046512153	736	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YNR062C_p	YNR062C	YNR062C	hom	Uncharacterized	0.827538944172843	0.203965829083556	no	999	0.1890165045907	654	NA					Putative membrane protein of unknown function	biological_process	molecular_function	integral to membrane
YDR297W	YDR297W	SUR2	hom	Verified	0.826979157150357	0.204124437613201	no	1000	0.219562197791556	734	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis	sphingolipid metabolic process	sphingosine hydroxylase activity	integral to membrane|endoplasmic reticulum membrane
YCR079W	YCR079W	PTC6	hom	Verified	0.826792555140634	0.204177325240096	no	1001	0.22012726008556	789	NA	FT	RESPONSE TO NUTRIENT LEVELS	MITOCHONDRION		Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase	mitochondrion degradation|positive regulation of catalytic activity|macroautophagy|protein dephosphorylation	protein serine/threonine phosphatase activity	mitochondrion|mitochondrial matrix|mitochondrial intermembrane space
YGR243W	YGR243W	FMP43	hom	Verified	0.825497775839006	0.204544522451148	no	1002	0.203741746844405	737	NA	FT		MITOCHONDRION		Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|mitochondrial membrane
YCR107W	YCR107W	AAD3	hom	Verified	0.825286202824811	0.204604561529607	no	1003	0.223821904855137	773	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YJR039W_p	YJR039W	YJR039W	hom	Uncharacterized	0.824750860213931	0.204756525067594	no	1004	0.166945680778911	582	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YDR500C	YDR500C	RPL37B	hom	Verified	0.824337619664572	0.20487387434094	no	1005	0.183543612159915	622	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLL057C	YLL057C	JLP1	hom	Verified	0.823479050693395	0.20511781280593	no	1006	0.173892177145615	560	NA	FT	OXIDATION-REDUCTION PROCESS			Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation	sulfur compound catabolic process	sulfonate dioxygenase activity	cellular_component
YJL192C	YJL192C	SOP4	hom	Verified	0.823385370670592	0.205144439816261	no	1007	0.270840485974975	928	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum
YKL110C	YKL110C	KTI12	hom	Verified	0.823287232879718	0.205172336076946	no	1008	0.223347969145318	776	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p	regulation of transcription from RNA polymerase II promoter|cell growth|tRNA wobble uridine modification	chromatin binding	nucleus|cytoplasm
YNL296W_d	YNL296W	YNL296W	hom	Dubious	0.822317281383453	0.205448171872042	no	1009	0.239905329868862	835	NA					Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog	Unknown	Unknown	Unknown
YIL100W_d	YIL100W	YIL100W	hom	Dubious	0.820979339307823	0.205829018376156	no	1010	0.215158457749387	685	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A	Unknown	Unknown	Unknown
YPR129W	YPR129W	SCD6	hom	Verified	0.820481804028353	0.205970749050255	no	1011	0.232122307201872	801	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress	stress granule assembly|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly	mRNA binding|RNA binding|eukaryotic initiation factor 4G binding	cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YMR245W_d	YMR245W	YMR245W	hom	Dubious	0.819093858319998	0.206366432855889	no	1012	0.258804113079648	899	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL183C	YDL183C	YDL183C	hom	Verified	0.819030043216087	0.206384636469563	no	1013	0.233321258669571	768	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene	potassium ion transport|proton transport	molecular_function	integral to mitochondrial inner membrane
YMR075C-A_d	YMR075C-A	YMR075C-A	hom	Dubious	0.817339739486472	0.206867151312398	no	1014	0.200524537656402	656	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W	Unknown	Unknown	Unknown
YOR360C	YOR360C	PDE2	hom	Verified	0.816204519659918	0.207191586142436	no	1015	0.230332810619763	759	NA	FT	SIGNALING	NUCLEUS		High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon	cAMP-mediated signaling	3',5'-cyclic-AMP phosphodiesterase activity	nucleus|cytoplasm
YGR159C	YGR159C	NSR1	hom	Verified	0.816090542013948	0.207224176465694	no	1016	0.220784463639314	711	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION		Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis	ribosomal small subunit assembly|rRNA processing	single-stranded DNA binding|RNA binding	mitochondrion|nucleolus|nucleus
YDR465C	YDR465C	RMT2	hom	Verified	0.815428545139428	0.207413525201698	no	1017	0.233791097701489	745	NA	FT		NUCLEUS		Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress	peptidyl-arginine methylation	protein-arginine N5-methyltransferase activity	nucleus|cytoplasm
YER152C	YER152C	YER152C	hom	Verified	0.814848118052371	0.207579626926689	no	1018	0.185693549364412	608	NA	FT		NUCLEUS		Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene	biological_process	2-aminoadipate transaminase activity	nucleus|cytoplasm
YML094W	YML094W	GIM5	hom	Verified	0.812945134973989	0.208124757599046	no	1019	0.203026452888301	716	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it	tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YPL097W	YPL097W	MSY1	hom	Verified	0.812729596157791	0.208186554312927	no	1020	0.220224715777733	750	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial tyrosyl-tRNA synthetase	mitochondrial tyrosyl-tRNA aminoacylation	tyrosine-tRNA ligase activity	mitochondrion
YCR028C	YCR028C	FEN2	hom	Verified	0.812433217251767	0.208271546209535	no	1021	0.233423120881096	768	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress	pantothenate transmembrane transport|endocytosis	pantothenate transmembrane transporter activity	integral to membrane|plasma membrane
YMR182C	YMR182C	RGM1	hom	Verified	0.81028368690405	0.208888574445683	no	1022	0.204760564992411	687	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nuclear chromatin
YNL154C	YNL154C	YCK2	hom	Verified	0.81015057490865	0.208926819965005	no	1023	0.216643774316671	751	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication	endocytosis|cell morphogenesis|protein phosphorylation|cytokinesis|response to glucose stimulus	protein serine/threonine kinase activity|protein kinase activity	plasma membrane|cellular bud neck|mating projection
YMR181C_p	YMR181C	YMR181C	hom	Uncharacterized	0.809874580177223	0.209006131458444	no	1024	0.203945492655093	683	NA					Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YOR170W_d	YOR170W	YOR170W	hom	Dubious	0.809795862310403	0.209028755544149	no	1025	0.210325702204992	699	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4	Unknown	Unknown	Unknown
YGR279C	YGR279C	SCW4	hom	Verified	0.808553397027859	0.209386040075137	no	1026	0.215630727107182	728	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating	conjugation with cellular fusion	glucosidase activity	extracellular region|fungal-type cell wall
YML024W	YML024W	RPS17A	hom	Verified	0.807286943029337	0.209750592398717	no	1027	0.196605998519772	657	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit
YLL060C	YLL060C	GTT2	hom	Verified	0.806839572675714	0.209879458346034	no	1028	0.203050530134305	723	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress	glutathione metabolic process	glutathione transferase activity	mitochondrion
YER166W	YER166W	DNF1	hom	Verified	0.805940837826565	0.210138481362564	no	1029	0.225237244930531	759	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|GOLGI APPARATUS|PLASMA MEMBRANE		Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase	intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity	phospholipid-translocating ATPase activity|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	mitochondrion|integral to membrane|plasma membrane
YHR080C	YHR080C	YHR080C	hom	Verified	0.805366002966903	0.210304252068512	no	1030	0.218357107497889	761	NA	FT		MITOCHONDRION		Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|ribosome
YMR305C	YMR305C	SCW10	hom	Verified	0.803766824209104	0.210765826522966	no	1031	0.211808325861471	696	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM		Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p	conjugation with cellular fusion	glucosidase activity	fungal-type cell wall|extracellular region|endoplasmic reticulum|cytoplasm
YNL079C	YNL079C	TPM1	hom	Verified	0.803626154883652	0.210806456631016	no	1032	0.215881078990612	768	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication	vacuole inheritance|exocytosis|intracellular mRNA localization|filamentous growth|budding cell apical bud growth|mitochondrion inheritance|budding cell isotropic bud growth|actin polymerization or depolymerization|actin filament organization|pseudohyphal growth|vesicle-mediated transport|establishment of cell polarity|actin filament bundle assembly	actin lateral binding	cellular bud neck contractile ring|actin filament bundle
YGL131C	YGL131C	SNT2	hom	Verified	0.802587379815029	0.211106632547262	no	1033	0.198934238540849	675	NA	FT		NUCLEUS|CHROMOSOME		DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress	biological_process	DNA binding	nucleus|Snt2C complex|cytoplasm
YBR206W_d	YBR206W	YBR206W	hom	Dubious	0.801995320381614	0.211277832601496	no	1034	0.222489380175798	769	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3	Unknown	Unknown	Unknown
YJL082W	YJL082W	IML2	hom	Verified	0.801817898575422	0.211329151770364	no	1035	0.197411651316817	680	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|nucleus|cytoplasm
YBR084C-A	YBR084C-A	RPL19A	hom	Verified	0.800787536104395	0.21162732790314	no	1036	0.202800982361934	682	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR314C	YDR314C	RAD34	hom	Verified	0.800018085017496	0.211850159544496	no	1037	0.214012505500696	684	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in nucleotide excision repair (NER); homologous to RAD4	nucleotide-excision repair	molecular_function	nucleus
YDR264C	YDR264C	AKR1	hom	Verified	0.799187041182549	0.212090982459302	no	1038	0.3368342778523	1147	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication	protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation	palmitoyltransferase activity	integral to membrane|Golgi apparatus|membrane
YJL115W	YJL115W	ASF1	hom	Verified	0.798861808764218	0.212185273059925	no	1039	0.191240666630786	629	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition	DNA replication-independent nucleosome assembly|histone acetylation|nucleosome disassembly|histone exchange|positive regulation of histone acetylation|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere|DNA replication-dependent nucleosome assembly|regulation of transcription from RNA polymerase II promoter in response to stress	histone binding	chromatin assembly complex
YKL162C-A_d	YKL162C-A	YKL162C-A	hom	Dubious	0.798313620516126	0.212344257929796	no	1040	0.201610769713155	715	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR089C	YMR089C	YTA12	hom	Verified	0.797883269870246	0.212469116446739	no	1041	0.171566834471478	620	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes	proteolysis|signal peptide processing|protein complex assembly|protein import into mitochondrial intermembrane space	metallopeptidase activity|protein binding|ATPase activity|ATP binding	mitochondrion|mitochondrial inner boundary membrane|mitochondrial inner membrane|m-AAA complex|cytoplasm
YDL051W	YDL051W	LHP1	hom	Verified	0.797832946977815	0.212483719531299	no	1042	0.214135071226689	727	NA	FT	RNA PROCESSING	NUCLEUS		RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen	tRNA processing	RNA binding|tRNA binding	nucleoplasm|nucleolus|nucleus
YMR232W	YMR232W	FUS2	hom	Verified	0.797720706244257	0.212516292524169	no	1043	0.163963553046747	566	NA	FT	SIGNALING	NUCLEUS|MITOCHONDRION|SITE OF POLARIZED GROWTH		Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating	karyogamy involved in conjugation with cellular fusion|regulation of termination of mating projection growth|cytogamy	molecular_function	mitochondrion|nucleus|mating projection tip|cytoplasm
YGR262C	YGR262C	BUD32	hom	Verified	0.797366760837825	0.212619028889141	no	1044	0.252359646092164	810	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|LIPID METABOLISM|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	NUCLEUS|CHROMOSOME		Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription	threonylcarbamoyladenosine metabolic process|protein phosphorylation|telomere maintenance|cellular bud site selection|positive regulation of transcription from RNA polymerase II promoter	protein serine/threonine kinase activity	EKC/KEOPS complex|nucleus|cytoplasm
YDR071C	YDR071C	PAA1	hom	Verified	0.797360513548071	0.21262084249094	no	1045	0.223076924490947	778	NA	FT	CHROMATIN ORGANIZATION			Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication	chromatin organization	diamine N-acetyltransferase activity|aralkylamine N-acetyltransferase activity	cytoplasm
YHR081W	YHR081W	LRP1	hom	Verified	0.797225163398428	0.212660137151775	no	1046	0.187827635655513	625	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination	U5 snRNA 3'-end processing|nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear retention of pre-mRNA at the site of transcription|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	double-stranded RNA binding|double-stranded DNA binding	nuclear exosome (RNase complex)
YPR201W	YPR201W	ARR3	hom	Verified	0.796589729368628	0.212844672124301	no	1047	0.197343434525769	715	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite	arsenite transport|antimonite transport	antiporter activity|arsenite transmembrane transporter activity|antimonite transmembrane transporter activity	integral to membrane|plasma membrane
YMR119W-A_d	YMR119W-A	YMR119W-A	hom	Dubious	0.795130450076186	0.213268811768516	no	1048	0.213362381385095	690	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR255W	YMR255W	GFD1	hom	Verified	0.792936469743796	0.213907418934414	no	1049	0.205223440878789	708	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress	mRNA export from nucleus	molecular_function	integral to membrane|nuclear pore|cytoplasm
YGL141W	YGL141W	HUL5	hom	Verified	0.792521430420017	0.214028350539894	no	1050	0.22389700809004	748	NA	FT	PROTEOLYSIS	NUCLEUS		Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD	ER-associated protein catabolic process|protein polyubiquitination	ubiquitin-ubiquitin ligase activity	proteasome complex|nucleus|cytoplasm
YGL220W	YGL220W	FRA2	hom	Verified	0.792148589046416	0.214137020688889	no	1051	0.213883319163019	715	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel	negative regulation of transcription from RNA polymerase II promoter in response to iron	molecular_function	cytosol|nucleus|cytoplasm
YOR150W	YOR150W	MRPL23	hom	Verified	0.791664618623404	0.214278128924441	no	1052	0.249050625838629	848	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YHR207C	YHR207C	SET5	hom	Verified	0.790742648212838	0.214547091699989	no	1053	0.222574713902452	789	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus	histone lysine methylation	S-adenosylmethionine-dependent methyltransferase activity	nuclear chromatin|nucleus|cytoplasm
YCR098C	YCR098C	GIT1	hom	Verified	0.790736985114325	0.214548744379506	no	1054	0.220690533669245	796	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability	transmembrane transport|glycerophosphodiester transport	glycerophosphodiester transmembrane transporter activity	integral to membrane|plasma membrane
YCL001W-A_p	YCL001W-A	YCL001W-A	hom	Uncharacterized	0.789263554557926	0.214978991564503	no	1055	0.239583028773712	854	NA					Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III	biological_process	molecular_function	cellular_component
YDR128W	YDR128W	MTC5	hom	Verified	0.788007408393075	0.215346186253147	no	1056	0.190981584863817	640	NA					Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress	biological_process	molecular_function	fungal-type vacuole membrane|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YPL032C	YPL032C	SVL3	hom	Verified	0.787461295190054	0.215505938641446	no	1057	0.252705001516908	866	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS	SITE OF POLARIZED GROWTH		Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress	endocytosis	molecular_function	cellular bud|cellular bud neck|cytoplasm
YOR142W	YOR142W	LSC1	hom	Verified	0.786362422861474	0.215827595746761	no	1058	0.195709180235273	687	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated	tricarboxylic acid cycle|succinyl-CoA metabolic process	succinate-CoA ligase (ADP-forming) activity	mitochondrial nucleoid|mitochondrion
YEL059C-A	YEL059C-A	SOM1	hom	Verified	0.785229607725176	0.216159479525042	no	1059	0.202548932008151	677	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs	proteolysis|mitochondrial respiratory chain complex assembly	endopeptidase activity	mitochondrial inner membrane peptidase complex|mitochondrial inner membrane
YML032C	YML032C	RAD52	hom	Verified	0.783948833683808	0.21653506692933	no	1060	0.21519226193945	721	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis	postreplication repair|telomere maintenance via recombination|meiotic joint molecule formation|meiotic DNA recombinase assembly|DNA recombinase assembly|DNA strand renaturation|double-strand break repair via synthesis-dependent strand annealing|double-strand break repair via single-strand annealing|double-strand break repair via break-induced replication	recombinase activity	nuclear chromosome|nucleus
YOR307C	YOR307C	SLY41	hom	Verified	0.783754700706051	0.216592029423049	no	1061	0.227994149964658	746	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM		Protein involved in ER-to-Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum
YDL123W	YDL123W	SNA4	hom	Verified	0.783482051616913	0.216672044747059	no	1062	0.233792629211827	761	NA					Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated	biological_process	molecular_function	fungal-type vacuole lumen|fungal-type vacuole membrane
YEL062W	YEL062W	NPR2	hom	Verified	0.783387978849127	0.2166996565925	no	1063	0.234432669106908	806	NA	FT	SIGNALING|RESPONSE TO NUTRIENT LEVELS			Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline	proline transport|urea transport|regulation of TOR signaling cascade|cellular response to amino acid starvation|response to drug|cellular response to nitrogen starvation	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YGR171C	YGR171C	MSM1	hom	Verified	0.782432988545012	0.216980076521756	no	1064	0.226177687390916	751	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p	methionyl-tRNA aminoacylation	methionine-tRNA ligase activity	mitochondrion
YBR018C	YBR018C	GAL7	hom	Verified	0.780723983178921	0.217482425863559	no	1065	0.214777809835038	742	NA	FT	CARBOHYDRATE METABOLISM			Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism	galactose catabolic process via UDP-galactose	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	cytoplasm
YOL067C	YOL067C	RTG1	hom	Verified	0.779369197431386	0.217881131621567	no	1066	0.245584121229465	821	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus	cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus|cytoplasm
YPR128C	YPR128C	ANT1	hom	Verified	0.779227714652859	0.217922793495976	no	1067	0.222839321635714	782	NA	FT	KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|PEROXISOME ORGANIZATION			Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation	ATP transport|fatty acid beta-oxidation|peroxisome organization	adenine nucleotide transmembrane transporter activity	integral to membrane|cytoplasm|integral to peroxisomal membrane
YER154W	YER154W	OXA1	hom	Verified	0.776169724031804	0.218824389908086	no	1068	0.237310902759809	846	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals	protein insertion into mitochondrial membrane from inner side|mitochondrial genome maintenance|mitochondrial proton-transporting ATP synthase complex assembly	mitochondrial ribosome binding|membrane insertase activity	mitochondrion|mitochondrial inner boundary membrane|integral to membrane|mitochondrial crista|mitochondrial large ribosomal subunit
YDR523C	YDR523C	SPS1	hom	Verified	0.775698796763903	0.21896342524683	no	1069	0.168648675207009	588	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis	ascospore wall assembly|ascospore formation|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	nucleus|prospore membrane|cytoplasm
YGR020C	YGR020C	VMA7	hom	Verified	0.774807125128996	0.219226819196614	no	1070	0.268281573100873	946	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YKR093W	YKR093W	PTR2	hom	Verified	0.774588535193233	0.219291417014873	no	1071	0.250197987674506	893	NA	FF|FT	PROTEIN LOCALIZATION	PLASMA MEMBRANE		Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p	dipeptide transport|tripeptide transport|peptide transport	dipeptide transporter activity|tripeptide transporter activity|peptide transporter activity	integral to membrane|plasma membrane
YHR120W	YHR120W	MSH1	hom	Verified	0.773936205520652	0.219484258863834	no	1072	0.20849833080951	741	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	MITOCHONDRION		DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis	DNA repair|mismatch repair|mitochondrial DNA repair|mitochondrion organization|reciprocal meiotic recombination|mitochondrial genome maintenance	guanine/thymine mispair binding|dinucleotide insertion or deletion binding|DNA-dependent ATPase activity	mitochondrion
YAR015W	YAR015W	ADE1	hom	Verified	0.77371325497529	0.219550189886644	no	1073	0.216937017888914	767	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	nucleus|cytoplasm
YJR109C	YJR109C	CPA2	hom	Verified	0.772929506155327	0.219782050657061	no	1074	0.194361906332395	648	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor	arginine biosynthetic process	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carbamoyl-phosphate synthase complex
YHR028C	YHR028C	DAP2	hom	Verified	0.772835322430552	0.219809923009543	no	1075	0.242858101444639	812	NA	FT	PROTEOLYSIS			Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p	protein processing	dipeptidyl-peptidase activity	fungal-type vacuole membrane
YNL058C_p	YNL058C	YNL058C	hom	Uncharacterized	0.77174464689736	0.220132840897826	no	1076	0.200257492075235	711	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene	biological_process	molecular_function	fungal-type vacuole
YDR080W	YDR080W	VPS41	hom	Verified	0.771682634244559	0.220151209245292	no	1077	0.222027621424512	762	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING			Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole organization|vesicle-mediated transport|protein transport|vacuole fusion, non-autophagic|vacuolar protein processing	Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding	endosome|fungal-type vacuole membrane|HOPS complex
YER092W	YER092W	IES5	hom	Verified	0.770903494799082	0.220382067751695	no	1078	0.229392198523603	822	NA	FT		NUCLEUS		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions	biological_process	molecular_function	nucleus
YKL057C	YKL057C	NUP120	hom	Verified	0.770180843833281	0.220596312744837	no	1079	0.257868772579856	894	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160	double-strand break repair|protein export from nucleus|ribosomal large subunit export from nucleus|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore outer ring
YHR202W_p	YHR202W	YHR202W	hom	Uncharacterized	0.768793836500553	0.221007854200488	no	1080	0.221774157848255	789	NA	FT	NUCLEOTIDE METABOLISM			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization	biological_process	molecular_function	cytosol|fungal-type vacuole
YKL124W	YKL124W	SSH4	hom	Verified	0.767921827890485	0.221266814268554	no	1081	0.171811852231702	620	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT			Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|vesicle-mediated transport	molecular_function	fungal-type vacuole
YDR298C	YDR298C	ATP5	hom	Verified	0.767599397613935	0.221362610198761	no	1082	0.234206089349818	800	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, stator stalk|mitochondrial proton-transporting ATP synthase complex
YBL065W_d	YBL065W	YBL065W	hom	Dubious	0.765541563111737	0.221974563356352	no	1083	0.23727743847186	761	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene	Unknown	Unknown	Unknown
YNL190W_p	YNL190W	YNL190W	hom	Uncharacterized	0.764440016882881	0.222302534663319	no	1084	0.236532728672853	811	NA					Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site	cellular response to water deprivation	molecular_function	fungal-type cell wall
YOR054C	YOR054C	VHS3	hom	Verified	0.763687016274983	0.222526889964987	no	1085	0.232973096241059	783	NA	FT	CELL CYCLE|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM			Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis	coenzyme A biosynthetic process|cellular monovalent inorganic cation homeostasis	phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity	phosphopantothenoylcysteine decarboxylase complex
YDR322C-A	YDR322C-A	TIM11	hom	Verified	0.763302217449937	0.222641589975364	no	1086	0.207440465707435	718	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase	protein oligomerization|cristae formation|ATP synthesis coupled proton transport	structural molecule activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YMR251W	YMR251W	GTO3	hom	Verified	0.761469204712629	0.22318843290839	no	1087	0.235123302672357	809	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Omega class glutathione transferase; putative cytosolic localization	glutathione metabolic process	glutathione transferase activity	cytoplasm
YCR087C-A_p	YCR087C-A	YCR087C-A	hom	Uncharacterized	0.761309223656874	0.223236196329858	no	1088	0.236019695275927	805	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene	biological_process	molecular_function	nucleolus
YEL005C	YEL005C	VAB2	hom	Verified	0.760726433638264	0.223410241408905	no	1089	0.221525441131886	741	NA					Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter	biological_process	molecular_function	cytoplasm
YCR092C	YCR092C	MSH3	hom	Verified	0.760467730536195	0.223487525535395	no	1090	0.230559519325971	821	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability	mismatch repair|mitotic recombination|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination	DNA insertion or deletion binding|mismatched DNA binding|double-strand/single-strand DNA junction binding|loop DNA binding|Y-form DNA binding	MutSbeta complex|nucleus|cytoplasm
YMR099C	YMR099C	YMR099C	hom	Verified	0.760364790281619	0.223518281802732	no	1091	0.241915667318104	809	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS	cellular carbohydrate metabolic process	glucose-6-phosphate 1-epimerase activity	nucleus|cytoplasm
YEL041W	YEL041W	YEF1	hom	Verified	0.760127364283909	0.22358922861002	no	1092	0.249219602517249	821	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication	NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	cellular_component
YNL243W	YNL243W	SLA2	hom	Verified	0.759975322565482	0.223634667910984	no	1093	0.224318737263635	759	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo	bipolar cellular bud site selection|fungal-type cell wall organization|actin filament organization|endocytosis|exocytosis	protein binding, bridging	incipient cellular bud site|mating projection tip|actin cortical patch
YIL020C	YIL020C	HIS6	hom	Verified	0.758244977164626	0.22415217003285	no	1094	0.222594052376052	753	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts	histidine biosynthetic process	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	intracellular
YER014C-A	YER014C-A	BUD25	hom	Verified	0.756354027970755	0.224718481564422	no	1095	0.209621835082172	678	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION			Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern	cellular bud site selection	molecular_function	cellular_component
YCR034W	YCR034W	FEN1	hom	Verified	0.756261762819223	0.22474613436927	no	1096	0.330306082789557	1123	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication	fatty acid elongation|vesicle-mediated transport|sphingolipid biosynthetic process	fatty acid elongase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YJL155C	YJL155C	FBP26	hom	Verified	0.756182461992465	0.224769903175998	no	1097	0.219843662945795	792	NA	FT	CARBOHYDRATE METABOLISM			Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress	glucose metabolic process	6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity	cytosol
YER109C	YER109C	FLO8	hom	Verified	0.755012109997376	0.225120858048228	no	1098	0.20298173753828	648	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene	biofilm formation|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YLR335W	YLR335W	NUP2	hom	Verified	0.754769585089781	0.225193623100353	no	1099	0.23391837233307	828	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CHROMOSOME	NUCLEAR PORE	Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization	rRNA export from nucleus|snRNA export from nucleus|nuclear pore organization|tRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA-binding (hnRNP) protein import into nucleus|ribosomal protein import into nucleus|snRNP protein import into nucleus|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|protein targeting to membrane|poly(A)+ mRNA export from nucleus|protein export from nucleus|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, non-stop decay	nucleocytoplasmic transporter activity	nuclear chromatin|mitochondrion|integral to membrane|nuclear pore
YIL072W	YIL072W	HOP1	hom	Verified	0.753561356274204	0.22555632795807	no	1100	0.255136869337623	860	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments	synaptonemal complex assembly|meiotic recombination checkpoint|synapsis	four-way junction DNA binding	condensed nuclear chromosome|lateral element
YDR092W	YDR092W	UBC13	hom	Verified	0.753205760482685	0.225663139152756	no	1101	0.213850124316127	742	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus	postreplication repair|protein monoubiquitination|protein polyubiquitination|free ubiquitin chain polymerization	ubiquitin-protein ligase activity	ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YNR064C	YNR064C	YNR064C	hom	Verified	0.751666503545332	0.226125819503426	no	1102	0.219513140375816	812	NA					Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides	response to toxin	epoxide hydrolase activity	cellular_component
YCR025C_d	YCR025C	YCR025C	hom	Dubious	0.750511888050518	0.226473233316798	no	1103	0.242440325093967	861	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene	Unknown	Unknown	Unknown
YNL257C	YNL257C	SIP3	hom	Verified	0.750033193765864	0.226617356615879	no	1104	0.260057431680764	886	NA	FT	TRANSCRIPTION FROM RNA POL II			Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	transcription cofactor activity	integral to membrane
YPL270W	YPL270W	MDL2	hom	Verified	0.749821767756269	0.226681028364255	no	1105	0.236412932425027	820	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis	oligopeptide transport|oligopeptide export from mitochondrion	oligopeptide-transporting ATPase activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YER178W	YER178W	PDA1	hom	Verified	0.747816793452331	0.227285335613492	no	1106	0.246667896033732	846	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose	acetyl-CoA biosynthetic process from pyruvate	pyruvate dehydrogenase (acetyl-transferring) activity	mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YIR033W	YIR033W	MGA2	hom	Verified	0.746419631829534	0.227706981851692	no	1107	0.18460869478221	591	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	molecular_function	integral to endoplasmic reticulum membrane|nucleus
YDL202W	YDL202W	MRPL11	hom	Verified	0.744285326956053	0.22835193811755	no	1108	0.233362226413657	799	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YMR105C	YMR105C	PGM2	hom	Verified	0.743818697251187	0.228493083548546	no	1109	0.207167489934561	662	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress	glucose 6-phosphate metabolic process|cellular calcium ion homeostasis|galactose catabolic process|cellular cation homeostasis|glucose 1-phosphate metabolic process|trehalose biosynthetic process|UDP-glucose metabolic process|glycogen biosynthetic process	phosphoglucomutase activity	cytoplasm
YGL244W	YGL244W	RTF1	hom	Verified	0.743168461297083	0.228689847621345	no	1110	0.286758076918762	995	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of chromatin silencing at telomere|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|negative regulation of transcription from RNA polymerase II promoter|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|global genome nucleotide-excision repair|snoRNA 3'-end processing|Unknown|transcription elongation from RNA polymerase II promoter	RNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YMR032W	YMR032W	HOF1	hom	Verified	0.741459316375556	0.229207495342498	no	1111	0.233674248861849	832	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p	cytokinesis after mitosis|barrier septum assembly involved in cell cycle cytokinesis|response to DNA damage stimulus|cytokinesis	cytoskeletal protein binding	cellular bud neck contractile ring|cellular bud neck septin ring
YPR070W	YPR070W	MED1	hom	Verified	0.740658464970758	0.229450274626129	no	1112	0.255278204037421	878	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	molecular_function	core mediator complex
YDR451C	YDR451C	YHP1	hom	Verified	0.73968056543753	0.229746921641386	no	1113	0.288729027646201	1008	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS|CHROMOSOME		Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nuclear chromatin|nucleus
YGR260W	YGR260W	TNA1	hom	Verified	0.738806830185001	0.230012151872388	no	1114	0.246432130040695	842	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)	nicotinamide mononucleotide transport	nicotinamide mononucleotide transmembrane transporter activity	mitochondrion|integral to membrane|integral to plasma membrane
YLR372W	YLR372W	SUR4	hom	Verified	0.738619692853453	0.230068981372858	no	1115	0.384172892314238	1273	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM	ENDOPLASMIC RETICULUM		Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis	post-Golgi vesicle-mediated transport|fatty acid elongation|fatty acid biosynthetic process|sphingolipid biosynthetic process	fatty acid elongase activity	integral to membrane|endoplasmic reticulum
YHR175W-A_p	YHR175W-A	YHR175W-A	hom	Uncharacterized	0.737331666336213	0.230460339817343	no	1116	0.209225930277196	677	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YKL034W	YKL034W	TUL1	hom	Verified	0.737314586452	0.230465531927416	no	1117	0.228430499206228	819	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein ubiquitination	ubiquitin-protein ligase activity	integral to membrane|Golgi apparatus
YDR090C_p	YDR090C	YDR090C	hom	Uncharacterized	0.736162312356577	0.230815962432477	no	1118	0.252635621863099	867	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YNL020C	YNL020C	ARK1	hom	Verified	0.735973214344609	0.230873499480426	no	1119	0.222832556264375	744	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication	regulation of endocytosis|actin filament organization|protein phosphorylation|cytokinesis|actin cortical patch assembly	protein serine/threonine kinase activity|protein kinase activity	mating projection tip|actin cortical patch
YNL108C_p	YNL108C	YNL108C	hom	Uncharacterized	0.735192204850691	0.231111222877273	no	1120	0.251731108164488	879	NA	FT		NUCLEUS		Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YIL009W	YIL009W	FAA3	hom	Verified	0.73325869446439	0.231700331374397	no	1121	0.229801288640724	788	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	long-chain fatty acid metabolic process	long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity	cellular_component
YPR095C	YPR095C	SYT1	hom	Verified	0.733141185462513	0.231736161367288	no	1122	0.239711606308823	828	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING	MITOCHONDRION|GOLGI APPARATUS		Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain	vesicle-mediated transport|exocytosis|positive regulation of ARF protein signal transduction	ARF guanyl-nucleotide exchange factor activity	mitochondrion|Golgi apparatus part
YGR078C	YGR078C	PAC10	hom	Verified	0.731915100323559	0.23211019445237	no	1123	0.267688892037154	925	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding	tubulin complex assembly	tubulin binding	prefoldin complex|polysome|cytoplasm
YNL162W-A_p	YNL162W-A	YNL162W-A	hom	Uncharacterized	0.731374866694179	0.232275106281669	no	1124	0.22186377125356	733	NA	FT		NUCLEUS		Putative protein of unknown function; identified by homology	biological_process	molecular_function	nucleus|cytoplasm
YML009W-B_d	YML009W-B	YML009W-B	hom	Dubious	0.729024748241946	0.232993262048546	no	1125	0.237378459616899	830	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition	Unknown	Unknown	Unknown
YHR025W	YHR025W	THR1	hom	Verified	0.726680522058547	0.233710844079922	no	1126	0.255968386964025	869	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway	threonine biosynthetic process|methionine metabolic process|isoleucine metabolic process|homoserine metabolic process	homoserine kinase activity	cellular_component
YLR419W_p	YLR419W	YLR419W	hom	Uncharacterized	0.725912439044947	0.233946225199117	no	1127	0.230426453433079	756	NA	FT		MITOCHONDRION		Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene	biological_process	molecular_function	mitochondrion|cytoplasm
YDL122W	YDL122W	UBP1	hom	Verified	0.725110284655777	0.234192187722548	no	1128	0.224949771315576	772	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains	protein deubiquitination	ubiquitin-specific protease activity	endoplasmic reticulum|cytoplasm
YOR386W	YOR386W	PHR1	hom	Verified	0.72330578504017	0.234746019713028	no	1129	0.252934436060905	869	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p	photoreactive repair	mRNA binding|deoxyribodipyrimidine photo-lyase activity	mitochondrion|nucleus
YNL054W	YNL054W	VAC7	hom	Verified	0.721888105387898	0.235181637411594	no	1130	0.186356210078031	654	NA	FT	LIPID METABOLISM			Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock	positive regulation of phosphatidylinositol biosynthetic process|positive regulation of kinase activity	molecular_function	fungal-type vacuole membrane|integral to membrane|PAS complex|vacuolar membrane|cytoplasm
YMR284W	YMR284W	YKU70	hom	Verified	0.721877214945323	0.235184985500663	no	1131	0.211719134141558	736	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME		Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair	chromatin assembly or disassembly|chromatin silencing|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette	damaged DNA binding|RNA binding	nuclear chromatin|nuclear telomeric heterochromatin|nuclear envelope|Ku70:Ku80 complex
YPL064C	YPL064C	CWC27	hom	Verified	0.719775548201468	0.235831601131347	no	1132	0.252789240038266	867	NA	FT	RNA PROCESSING	NUCLEUS		Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	U2-type spliceosomal complex
YER114C	YER114C	BOI2	hom	Verified	0.718113930747892	0.236343520647973	no	1133	0.273526704907045	915	NA	FT	SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication	cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction	phospholipid binding	site of polarized growth|cellular bud|cellular bud neck
YBL079W	YBL079W	NUP170	hom	Verified	0.718032416700765	0.236368649641197	no	1134	0.257162766373095	885	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication	nucleocytoplasmic transport|chromosome segregation|protein targeting to nuclear inner membrane|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YDL186W_p	YDL186W	YDL186W	hom	Uncharacterized	0.717210986962074	0.236621960494937	no	1135	0.229773261870693	760	NA					Putative protein of unknown function; YDL186W is not an essential gene	biological_process	molecular_function	cellular_component
YHR092C	YHR092C	HXT4	hom	Verified	0.716456184731119	0.236854856501353	no	1136	0.196582549357432	671	NA	FT		PLASMA MEMBRANE		High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication	hexose transport	pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YDR363W-A	YDR363W-A	SEM1	hom	Verified	0.716391004028471	0.236874974070835	no	1137	0.24632945708135	871	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|PROTEOLYSIS|RNA LOCALIZATION	NUCLEUS		Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress	proteasome assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of cell cycle|mRNA export from nucleus|exocytosis|filamentous growth|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|proteasome storage granule|proteasome regulatory particle, lid subcomplex
YCR091W	YCR091W	KIN82	hom	Verified	0.715977096384362	0.237002745701307	no	1138	0.213217239160854	755	NA	FT	MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION			Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p	phospholipid translocation|protein phosphorylation|response to pheromone	protein kinase activity	cellular_component
YHL005C_d	YHL005C	YHL005C	hom	Dubious	0.715912137648469	0.237022801641027	no	1139	0.218158095073001	770	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W	Unknown	Unknown	Unknown
YJL110C	YJL110C	GZF3	hom	Verified	0.714646465972556	0.237413762489718	no	1140	0.24150731481083	798	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication	maintenance of protein location in nucleus|nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YAL046C	YAL046C	AIM1	hom	Verified	0.714264613778773	0.237531784568001	no	1141	0.246547545812097	856	NA					Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YLR366W_d	YLR366W	YLR366W	hom	Dubious	0.713246025579764	0.23784676513545	no	1142	0.235105977514686	777	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A	Unknown	Unknown	Unknown
YNL055C	YNL055C	POR1	hom	Verified	0.712883161915341	0.237959029679914	no	1143	0.270518650896095	927	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication	DNA transport|mitochondrion organization|apoptotic process|ion transport|cell redox homeostasis	voltage-gated anion channel activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YER101C	YER101C	AST2	hom	Verified	0.712760967579793	0.237996841301706	no	1144	0.242859236868451	838	NA	FT	PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS			Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication	protein targeting to membrane	molecular_function	cytoplasm
YBR174C_d	YBR174C	YBR174C	hom	Dubious	0.712403645965222	0.238107429231537	no	1145	0.244061714546292	863	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective	Unknown	Unknown	Unknown
YGL095C	YGL095C	VPS45	hom	Verified	0.70835376498597	0.239362798376213	no	1146	0.323367138179734	1114	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment	vacuole inheritance|CVT pathway|positive regulation of SNARE complex assembly|Golgi vesicle fusion to target membrane|Golgi to vacuole transport|vacuole organization|vacuolar acidification|protein targeting to vacuole|Golgi to endosome transport	unfolded protein binding|SNARE binding	cytosol|SNARE complex|Golgi membrane|extrinsic to membrane
YDR346C	YDR346C	SVF1	hom	Verified	0.708260620585419	0.239391713446141	no	1147	0.266872585092387	924	NA	FT	RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance	cellular response to oxidative stress	molecular_function	nucleus|cytoplasm
YLR144C	YLR144C	ACF2	hom	Verified	0.708170456534531	0.239419705135033	no	1148	0.235111191581882	814	NA	FT	CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION			Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress	actin cytoskeleton organization	glucan endo-1,3-beta-D-glucosidase activity	intracellular
YFR008W	YFR008W	FAR7	hom	Verified	0.708109094376799	0.239438756215502	no	1149	0.244424248667146	859	NA	FT	CELL CYCLE|SIGNALING			Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	cellular_component
YIL140W	YIL140W	AXL2	hom	Verified	0.707807128560165	0.239532519461181	no	1150	0.235304062307315	807	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate	axial cellular bud site selection|cellular bud site selection	molecular_function	integral to plasma membrane|cellular bud neck|septin ring
YMR241W	YMR241W	YHM2	hom	Verified	0.707761838285024	0.239546584249082	no	1151	0.245478855354373	846	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome	tricarboxylic acid transport|mitochondrial citrate transport|alpha-ketoglutarate transport|mitochondrial genome maintenance	tricarboxylate secondary active transmembrane transporter activity|DNA binding	mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YBL095W_p	YBL095W	YBL095W	hom	Uncharacterized	0.707662399847167	0.239577466202531	no	1152	0.219222238158873	760	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGR096W	YGR096W	TPC1	hom	Verified	0.707612358805684	0.239593007947614	no	1153	0.269960185185841	892	NA	FT		MITOCHONDRION		Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family	thiamine pyrophosphate transport	thiamine transmembrane transporter activity	integral to membrane|integral to mitochondrial inner membrane
YBR181C	YBR181C	RPS6B	hom	Verified	0.707025047858075	0.239775456091308	no	1154	0.242273709020363	829	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|cytoplasm
YHR103W	YHR103W	SBE22	hom	Verified	0.706152201531017	0.240046745782303	no	1155	0.243577036473476	822	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	GOLGI APPARATUS		Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth	fungal-type cell wall organization	molecular_function	cytoplasm
YCR076C	YCR076C	FUB1	hom	Verified	0.703564474048457	0.240852020946509	no	1156	0.284866596812846	945	NA					Putative protein of unknown function; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; exhibits boundary activity which blocks the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene	biological_process	proteasome binding	cellular_component
YER145C	YER145C	FTR1	hom	Verified	0.701430261881316	0.241517270969134	no	1157	0.250308742665972	902	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress	iron assimilation by reduction and transport|high-affinity iron ion transport|transmembrane transport	iron ion transmembrane transporter activity	high affinity iron permease complex|integral to membrane|plasma membrane
YER121W_p	YER121W	YER121W	hom	Uncharacterized	0.701316266831346	0.241552832137443	no	1158	0.265330606727522	900	NA					Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy	biological_process	molecular_function	cellular_component
YPR005C	YPR005C	HAL1	hom	Verified	0.700516623202978	0.241802363768683	no	1159	0.241356836783607	833	NA	FT	TRANSCRIPTION FROM RNA POL II			Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p	response to salt stress|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YIL154C	YIL154C	IMP2'	hom	Verified	0.699815067514087	0.242021401856721	no	1160	0.298111864324876	1051	NA	FF|FT	RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS			Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat	DNA repair|cellular carbohydrate metabolic process	transcription coactivator activity	cytoplasm
YOR234C	YOR234C	RPL33B	hom	Verified	0.699646217333624	0.242074135929864	no	1161	0.24105059656857	808	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YNL095C_p	YNL095C	YNL095C	hom	Uncharacterized	0.699103962736997	0.242243531109937	no	1162	0.236847271498801	842	NA					Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YOR290C	YOR290C	SNF2	hom	Verified	0.697971293624674	0.242597573341137	no	1163	0.320159459884032	1101	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|double-strand break repair|strand invasion|positive regulation of mating type switching|sucrose catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|nucleosome mobilization|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter	histone acetyl-lysine binding|RNA polymerase II activating transcription factor binding|DNA-dependent ATPase activity|nucleosomal DNA binding	SWI/SNF complex|nucleus
YIL050W	YIL050W	PCL7	hom	Verified	0.695635251341145	0.243328642010413	no	1164	0.187156853698075	645	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated	regulation of glycogen catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of protein stability|regulation of glycogen biosynthetic process	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YPR091C	YPR091C	NVJ2	hom	Verified	0.693342557947078	0.24404730066453	no	1165	0.220045033067078	724	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments	biological_process	lipid binding	ribosome|nucleus-vacuole junction|endoplasmic reticulum
YGR101W	YGR101W	PCP1	hom	Verified	0.69311403428892	0.244118995482568	no	1166	0.257664172413786	896	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases	signal peptide processing|regulation of mitochondrion organization	serine-type endopeptidase activity	integral to membrane|mitochondrial inner membrane
YDR541C_p	YDR541C	YDR541C	hom	Uncharacterized	0.692707946517881	0.244246425580657	no	1167	0.248362993867472	852	NA	FT	OXIDATION-REDUCTION PROCESS			Putative dihydrokaempferol 4-reductase	biological_process	carbonyl reductase (NADPH) activity	cellular_component
YNL073W	YNL073W	MSK1	hom	Verified	0.691809563374547	0.24452846504275	no	1168	0.252939645117138	870	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION	MITOCHONDRION		Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)	tRNA import into mitochondrion|lysyl-tRNA aminoacylation|mitochondrial lysyl-tRNA aminoacylation|mitochondrial translation	lysine-tRNA ligase activity	mitochondrion
YMR165C	YMR165C	PAH1	hom	Verified	0.691723619281153	0.244555455624099	no	1169	0.248174774374421	861	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2	plasmid maintenance|vacuole fusion, non-autophagic|lipid particle organization|aerobic respiration|phospholipid biosynthetic process	phosphatidate phosphatase activity	cytosol|nuclear membrane|vacuole|cytoplasm|extrinsic to membrane
YKL039W	YKL039W	PTM1	hom	Verified	0.689466525042215	0.245264865957715	no	1170	0.233912377339671	774	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YPL088W_p	YPL088W	YPL088W	hom	Uncharacterized	0.688930276504766	0.245433572705176	no	1171	0.243155689509209	830	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YDR475C	YDR475C	JIP4	hom	Verified	0.688158665918351	0.245676435028076	no	1172	0.238630592165763	810	NA					Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence	biological_process	molecular_function	cellular_component
YDR154C_d	YDR154C	YDR154C	hom	Dubious	0.687249600914826	0.245962726253583	no	1173	0.215156927454455	723	NA					Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein	Unknown	Unknown	Unknown
YBR031W	YBR031W	RPL4A	hom	Verified	0.686297801876917	0.246262667408837	no	1174	0.237604178373953	848	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR442W_d	YDR442W	YDR442W	hom	Dubious	0.685053374610772	0.246655120337207	no	1175	0.277846987165957	957	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL219C	YNL219C	ALG9	hom	Verified	0.679794632473651	0.248317252895513	no	1176	0.261591165192602	885	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation	dolichol-linked oligosaccharide biosynthetic process|protein glycosylation	mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YGL229C	YGL229C	SAP4	hom	Verified	0.679629793798281	0.248369449862548	no	1177	0.253442883570156	839	NA	FT	CELL CYCLE	MITOCHONDRION		Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p	G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	mitochondrion|cytoplasm
YDR250C_d	YDR250C	YDR250C	hom	Dubious	0.678501287744434	0.248726953806684	no	1178	0.250060273971976	861	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR035C_d	YKR035C	OPI8	hom	Dubious	0.678453136945606	0.248742213783879	no	1179	0.287152598641787	986	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A	Unknown	Unknown	Unknown
YPR121W	YPR121W	THI22	hom	Verified	0.677892922474689	0.248919793892772	no	1180	0.219476318310872	727	NA					Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis	thiamine biosynthetic process	phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity	cellular_component
YPL009C	YPL009C	TAE2	hom	Verified	0.677887325070369	0.248921568531614	no	1181	0.247380938702284	859	NA	FT	TRANSLATION			Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	cytoplasmic translation	molecular_function	ribosome|cytoplasm
YOL137W	YOL137W	BSC6	hom	Verified	0.677701471628027	0.248980496584757	no	1182	0.26239494036296	895	NA	FT		GOLGI APPARATUS		Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression	biological_process	molecular_function	COPI-coated vesicle|integral to membrane|clathrin-coated vesicle
YGR027C	YGR027C	RPS25A	hom	Verified	0.676794492425281	0.249268176527943	no	1183	0.272819945616165	930	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YML079W_p	YML079W	YML079W	hom	Uncharacterized	0.675888284441076	0.249555788270422	no	1184	0.254081862546622	826	NA	FT		NUCLEUS		Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YFR036W	YFR036W	CDC26	hom	Verified	0.674490759476595	0.249999679274407	no	1185	0.297786798493754	1067	NA	FF|FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YNR052C	YNR052C	POP2	hom	Verified	0.674169764423826	0.25010169495415	no	1186	0.326214134175897	1119	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS|SITE OF POLARIZED GROWTH		RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation	regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter	3'-5'-exoribonuclease activity	CCR4-NOT core complex|mating projection tip|cytoplasmic mRNA processing body|cytoplasm
YDL231C	YDL231C	BRE4	hom	Verified	0.673761880976997	0.250231356551861	no	1187	0.255587689384409	856	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport	endocytosis	molecular_function	integral to membrane
YDR024W_d	YDR024W	FYV1	hom	Dubious	0.673508943360088	0.250311780501742	no	1188	0.268175801266306	929	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin	Unknown	Unknown	Unknown
YJL148W	YJL148W	RPA34	hom	Verified	0.672339256872451	0.250683871724226	no	1189	0.188027714517887	636	NA	FT		NUCLEUS		RNA polymerase I subunit A34.5	transcription elongation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	molecular_function	DNA-directed RNA polymerase I complex|nucleolus|nucleus
YLL002W	YLL002W	RTT109	hom	Verified	0.672193972505476	0.250730108858117	no	1190	0.256442769277373	880	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS		Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p	negative regulation of transposition, RNA-mediated|histone acetylation|double-strand break repair via nonhomologous end joining|response to DNA damage stimulus|regulation of transcription from RNA polymerase II promoter in response to stress	H3 histone acetyltransferase activity	nucleus
YPL274W	YPL274W	SAM3	hom	Verified	0.669547759716793	0.25157306270453	no	1191	0.291921664916082	967	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p	spermidine transport|putrescine transport|S-adenosylmethionine transport	S-adenosylmethionine transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity	integral to membrane|plasma membrane
YPL034W_p	YPL034W	YPL034W	hom	Uncharacterized	0.669388417095436	0.25162386921172	no	1192	0.26504752685318	916	NA					Putative protein of unknown function; YPL034W is not essential gene	biological_process	molecular_function	cellular_component
YDR162C	YDR162C	NBP2	hom	Verified	0.66932530026751	0.251643995555348	no	1193	0.336256794658134	1138	NA	FF|FT	PROTEIN PHOSPHORYLATION	NUCLEUS		Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)	negative regulation of protein kinase activity|response to heat|hyperosmotic response	molecular_function	nucleus|cytoplasm
YNL123W	YNL123W	NMA111	hom	Verified	0.668872708610333	0.251788340375734	no	1194	0.292326240871006	1003	NA	FT	LIPID METABOLISM|PROTEOLYSIS	NUCLEUS		Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases	apoptotic process|cellular lipid metabolic process|protein catabolic process|cellular response to heat	serine-type peptidase activity	nucleus
YLR244C	YLR244C	MAP1	hom	Verified	0.666824770278797	0.2524420343252	no	1195	0.266704603639312	877	NA	FT	PROTEOLYSIS		RIBOSOME	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p	negative regulation of gene expression|protein initiator methionine removal involved in protein maturation	metalloaminopeptidase activity|mRNA binding	cytosolic ribosome
YGR167W	YGR167W	CLC1	hom	Verified	0.664588787044364	0.253156771530036	no	1196	0.287775803642083	998	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE		Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W	endocytosis|vesicle-mediated transport	structural molecule activity	clathrin vesicle coat
YGR059W	YGR059W	SPR3	hom	Verified	0.663992082006296	0.253347689428663	no	1197	0.251474967266976	859	NA	FT	CELL CYCLE	SITE OF POLARIZED GROWTH|CYTOSKELETON		Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI	ascospore formation	structural molecule activity	septin complex|ascospore wall|prospore membrane
YML005W	YML005W	TRM12	hom	Verified	0.663874083615483	0.253385452394569	no	1198	0.279906660496797	949	NA	FT	RNA PROCESSING			S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA	wybutosine biosynthetic process|tRNA methylation	S-adenosylmethionine-dependent methyltransferase activity|transferase activity, transferring alkyl or aryl (other than methyl) groups	cytoplasm
YBR194W	YBR194W	AIM4	hom	Verified	0.662862565574972	0.253709289350837	no	1199	0.293852489076096	1034	NA					Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress	biological_process	molecular_function	cytoplasm
YDR169C-A_p	YDR169C-A	YDR169C-A	hom	Uncharacterized	0.660767372720884	0.254380754906402	no	1200	0.271851101823433	916	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YJL063C	YJL063C	MRPL8	hom	Verified	0.660681537193741	0.254408283247352	no	1201	0.274121831926388	987	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial genome maintenance|mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGR203W	YGR203W	YCH1	hom	Verified	0.660654914605205	0.254416821703931	no	1202	0.25475820424579	853	NA	FT		NUCLEUS		Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	dephosphorylation	phosphatase activity|protein tyrosine phosphatase activity|thiosulfate sulfurtransferase activity	nucleus|cytoplasm
YGR234W	YGR234W	YHB1	hom	Verified	0.660597553429351	0.254435219219863	no	1203	0.23144721452016	809	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	response to stress	nitric oxide reductase activity	cytosol|mitochondrion|mitochondrial matrix|cytoplasm
YDR352W	YDR352W	YPQ2	hom	Verified	0.660347064280871	0.254515567061522	no	1204	0.229714940265202	789	NA					Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YLR373C	YLR373C	VID22	hom	Verified	0.660273226125055	0.254539254202763	no	1205	0.270315756664284	957	NA	FT	PROTEIN LOCALIZATION	NUCLEUS|PLASMA MEMBRANE		Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles	vacuolar protein catabolic process	molecular_function	integral to plasma membrane
YNR013C	YNR013C	PHO91	hom	Verified	0.659929276314835	0.254649607871584	no	1206	0.269881022562992	912	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth	phosphate ion transport|polyphosphate metabolic process	phosphate ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|membrane
YNL051W	YNL051W	COG5	hom	Verified	0.659228109934905	0.254874649327654	no	1207	0.325179385122055	1095	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YBL028C	YBL028C	YBL028C	hom	Verified	0.658720323177257	0.255037689975452	no	1208	0.277395062378959	916	NA	FT		NUCLEUS		Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YPR160W	YPR160W	GPH1	hom	Verified	0.658429037150038	0.2551312409861	no	1209	0.224420531499219	753	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway	glycogen catabolic process	glycogen phosphorylase activity	cytoplasm
YML016C	YML016C	PPZ1	hom	Verified	0.658292825554594	0.255174993603352	no	1210	0.273865166181889	922	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular sodium ion homeostasis|cellular protein localization|protein dephosphorylation	protein serine/threonine phosphatase activity	extrinsic to plasma membrane|nucleus|cytoplasm
YML009C-A_d	YML009C-A	YML009C-A	hom	Dubious	0.658131133312489	0.255226935968927	no	1211	0.276747560025634	972	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAL008W	YAL008W	FUN14	hom	Verified	0.657634802208644	0.255386412969282	no	1212	0.273354724458561	922	NA	FT		MITOCHONDRION		Mitochondrial protein of unknown function	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YOL132W	YOL132W	GAS4	hom	Verified	0.657286317599153	0.2554984162695	no	1213	0.243032092167736	814	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall	ascospore wall assembly	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane
YKR007W	YKR007W	MEH1	hom	Verified	0.656045232100883	0.255897510732343	no	1214	0.267713013029544	917	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS			Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification	microautophagy|vacuolar acidification	molecular_function	fungal-type vacuole membrane|EGO complex|late endosome membrane
YMR167W	YMR167W	MLH1	hom	Verified	0.655885164819798	0.255949007061623	no	1215	0.230560007768594	791	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer	mismatch repair|meiotic mismatch repair|reciprocal meiotic recombination|meiotic heteroduplex formation	double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding	mitochondrion|nucleus|MutLalpha complex|MutLbeta complex|cytoplasm
YPL119C-A_p	YPL119C-A	YPL119C-A	hom	Uncharacterized	0.655124553371494	0.25619378239665	no	1216	0.253956207225827	853	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YLR084C	YLR084C	RAX2	hom	Verified	0.654786507040933	0.25630260956905	no	1217	0.287519772324977	971	NA	FT	CELL CYCLE|CELL DIVISION	MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p	cellular bud site selection	molecular_function	mitochondrion|cellular bud scar|cellular bud neck|membrane
YPL003W	YPL003W	ULA1	hom	Verified	0.654759416233957	0.256311331948692	no	1218	0.260409927182035	892	NA					Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation	protein neddylation	NEDD8 activating enzyme activity	cellular_component
YPR145W	YPR145W	ASN1	hom	Verified	0.6544312497432	0.256417003426198	no	1219	0.268918498147412	917	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication	asparagine biosynthetic process	asparagine synthase (glutamine-hydrolyzing) activity	cytoplasm
YMR155W_p	YMR155W	YMR155W	hom	Uncharacterized	0.653444660109256	0.256734827563049	no	1220	0.250081600793284	888	NA					Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen	biological_process	molecular_function	integral to membrane
YNL010W_p	YNL010W	YNL010W	hom	Uncharacterized	0.653294000050727	0.256783379872222	no	1221	0.278712598778449	950	NA	FT		NUCLEUS		Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation	biological_process	molecular_function	nucleus|cytoplasm
YGL139W	YGL139W	FLC3	hom	Verified	0.650607491188941	0.257649946687302	no	1222	0.242951548047392	842	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER	FAD transport|transmembrane transport	FAD transmembrane transporter activity	mitochondrion|integral to membrane|endoplasmic reticulum
YGL252C	YGL252C	RTG2	hom	Verified	0.650313456614583	0.257744883297798	no	1223	0.275885852713917	963	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|SIGNALING|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p	maintenance of DNA trinucleotide repeats|regulation of transcription from RNA polymerase II promoter|Unknown|nitrogen catabolite regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway|transcription factor import into nucleus	RNA polymerase II transcription factor binding transcription factor activity	SLIK (SAGA-like) complex|transcriptionally active chromatin|cytoplasm
YEL017C-A	YEL017C-A	PMP2	hom	Verified	0.649824618399828	0.257902757443566	no	1224	0.272282064845383	938	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication	cation transport	molecular_function	membrane
YDR378C	YDR378C	LSM6	hom	Verified	0.649631214945095	0.25796523245933	no	1225	0.270365177055312	945	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasmic mRNA processing body
YIL046W-A_p	YIL046W-A	YIL046W-A	hom	Uncharacterized	0.648794531338938	0.258235596341192	no	1226	0.251204512431777	871	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YBR183W	YBR183W	YPC1	hom	Verified	0.64855814467261	0.258312008348736	no	1227	0.267923997896233	916	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication	ceramide catabolic process|ceramide biosynthetic process	phytoceramidase activity|sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YPL155C	YPL155C	KIP2	hom	Verified	0.648431289673426	0.258353019067376	no	1228	0.217121695921281	760	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	MITOCHONDRION|CYTOSKELETON		Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle	nuclear migration along microtubule|mitotic anaphase B|negative regulation of microtubule depolymerization	microtubule motor activity	mitochondrion|kinesin complex|cytoplasmic microtubule
YJL106W	YJL106W	IME2	hom	Verified	0.64823867126358	0.258415296767803	no	1229	0.249557559446281	837	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p	protein phosphorylation|regulation of meiosis	protein kinase activity	nucleus
YMR106C	YMR106C	YKU80	hom	Verified	0.648110311759557	0.258456802491285	no	1230	0.244662428241097	881	NA	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair	chromatin assembly or disassembly|protein localization to chromosome|chromatin silencing|double-strand break repair via nonhomologous end joining|donor selection|telomere maintenance|double-strand break repair via homologous recombination	damaged DNA binding|RNA binding|DNA binding|telomeric DNA binding	nuclear chromatin|nuclear telomeric heterochromatin|Ku70:Ku80 complex
YLL016W	YLL016W	SDC25	hom	pseudogene	0.647540847135701	0.258640983521043	no	1231	0.254981192286797	872	NA	FT	SIGNALING			Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication	Ras protein signal transduction	Ras guanyl-nucleotide exchange factor activity	cellular_component
YHR152W	YHR152W	SPO12	hom	Verified	0.647446499925885	0.258671504648174	no	1232	0.258091726868281	880	NA	FT	CELL CYCLE	NUCLEUS		Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis	regulation of exit from mitosis|mitotic cell cycle|meiosis I	molecular_function	nucleolus|nucleus
YPR122W	YPR122W	AXL1	hom	Verified	0.645922318895432	0.259164832300945	no	1233	0.246637417815197	861	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS	SITE OF POLARIZED GROWTH		Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells	peptide pheromone maturation|axial cellular bud site selection	metalloendopeptidase activity	mating projection tip|cellular bud neck
YHR138C	YHR138C	YHR138C	hom	Verified	0.645862501924561	0.259184203015728	no	1234	0.259706399394448	867	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress	vacuole fusion, non-autophagic	endopeptidase inhibitor activity	cellular_component
YIR020W-A_d	YIR020W-A	YIR020W-A	hom	Dubious	0.645772422439505	0.259213375146189	no	1235	0.272350292801671	966	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL106W	YKL106W	AAT1	hom	Verified	0.645413604831626	0.259329594629096	no	1236	0.242388898406465	840	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis	aspartate catabolic process|chronological cell aging|replicative cell aging|asparagine biosynthetic process from oxaloacetate|aspartate biosynthetic process	L-aspartate:2-oxoglutarate aminotransferase activity	mitochondrion
YNL066W	YNL066W	SUN4	hom	Verified	0.642428961380918	0.260297350166908	no	1237	0.277810100305691	926	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family	mitochondrion organization	glucosidase activity	fungal-type cell wall|mitochondrial matrix
YMR069W	YMR069W	NAT4	hom	Verified	0.642261287964025	0.260351772574696	no	1238	0.281895345610633	968	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A	histone acetylation	histone acetyltransferase activity	nucleus|cytoplasm
YCR016W_p	YCR016W	YCR016W	hom	Uncharacterized	0.642145813740229	0.260389255897191	no	1239	0.223791900830582	781	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	nucleolus|nucleus
YPL080C_d	YPL080C	YPL080C	hom	Dubious	0.638540603984043	0.261560915711936	no	1240	0.234412950385438	767	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL037C_d	YOL037C	YOL037C	hom	Dubious	0.637671194702776	0.261843870145552	no	1241	0.275524950832192	931	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W	Unknown	Unknown	Unknown
YAR018C	YAR018C	KIN3	hom	Verified	0.634187218446823	0.262979323987187	no	1242	0.281289521976353	942	NA	FT	PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION			Nonessential serine/threonine protein kinase; possible role in DNA damage response	chromosome segregation|protein phosphorylation	protein kinase activity	cellular_component
YMR031C	YMR031C	EIS1	hom	Verified	0.634039435076622	0.26302754327472	no	1243	0.273778506634916	900	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress	eisosome assembly	molecular_function	eisosome|mitochondrion|membrane raft|cytoplasm
YOR374W	YOR374W	ALD4	hom	Verified	0.633591141175461	0.26317384185426	no	1244	0.252724539019939	859	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed	NADPH regeneration|ethanol metabolic process|pyruvate metabolic process|acetate biosynthetic process	aldehyde dehydrogenase [NAD(P)+] activity|aldehyde dehydrogenase (NAD) activity	mitochondrial nucleoid|mitochondrion
YDR114C_p	YDR114C	YDR114C	hom	Uncharacterized	0.632627186802	0.26348856451216	no	1245	0.281309168325174	951	NA					Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium	biological_process	molecular_function	cellular_component
YKR087C	YKR087C	OMA1	hom	Verified	0.63213199705968	0.263650314279253	no	1246	0.256345187890346	914	NA	FT	PROTEOLYSIS	MITOCHONDRION		Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes	misfolded or incompletely synthesized protein catabolic process	metalloendopeptidase activity	mitochondrion|mitochondrial inner membrane
YNL087W	YNL087W	TCB2	hom	Verified	0.631339999294705	0.263909119267044	no	1247	0.265546424919477	908	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud	biological_process	lipid binding	cellular bud|cortical endoplasmic reticulum
YMR015C	YMR015C	ERG5	hom	Verified	0.630937525524254	0.264040687200464	no	1248	0.308234835904994	1078	NA	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM		C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs	ergosterol biosynthetic process	C-22 sterol desaturase activity	endoplasmic reticulum
YGR225W	YGR225W	AMA1	hom	Verified	0.629299120295437	0.264576623588601	no	1249	0.259482530131897	897	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis	ascospore wall assembly|positive regulation of protein catabolic process|ascospore formation|meiosis I	enzyme activator activity	anaphase-promoting complex
YMR027W_p	YMR027W	YMR027W	hom	Uncharacterized	0.628727815891711	0.264763632199056	no	1250	0.271659834328322	945	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YBR085C-A	YBR085C-A	YBR085C-A	hom	Verified	0.628075933322946	0.26497709902413	no	1251	0.244614325841059	864	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YLR108C	YLR108C	YLR108C	hom	Verified	0.627961282166933	0.26501465197172	no	1252	0.280758412452096	954	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus
YLR273C	YLR273C	PIG1	hom	Verified	0.627483543269417	0.265171160122621	no	1253	0.22948953670221	788	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase	regulation of glycogen biosynthetic process	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex
YLR247C	YLR247C	IRC20	hom	Verified	0.627477871506733	0.265173018484513	no	1254	0.238475650948465	833	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci	double-strand break repair via synthesis-dependent strand annealing	helicase activity	mitochondrion|nucleus
YMR097C	YMR097C	MTG1	hom	Verified	0.627135176720404	0.265285315236814	no	1255	0.282436267239525	989	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals	mitochondrial translation	GTPase activity	mitochondrion|mitochondrial inner membrane
YFL054C_p	YFL054C	YFL054C	hom	Uncharacterized	0.62687636391053	0.265370140923477	no	1256	0.256025291716696	860	NA					Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol	water transport|transmembrane transport	water channel activity|glycerol transmembrane transporter activity|transporter activity	integral to membrane
YHR021W-A_p	YHR021W-A	ECM12	hom	Uncharacterized	0.624825441074781	0.266042815599284	no	1257	0.257951453483167	895	NA	FT	CELL WALL ORG/BIOGENESIS			Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity	fungal-type cell wall organization	molecular_function	cellular_component
YBR010W	YBR010W	HHT1	hom	Verified	0.624126415903534	0.266272283490853	no	1258	0.278813407912865	968	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation	chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint	DNA binding	replication fork protection complex|nucleus|nuclear nucleosome
YCR020C-A	YCR020C-A	MAK31	hom	Verified	0.623763777405858	0.26639136571164	no	1259	0.249450709590091	850	NA					Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex
YER143W	YER143W	DDI1	hom	Verified	0.621989812634518	0.266974283370839	no	1260	0.235788818813735	802	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS	PLASMA MEMBRANE		DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains	vesicle-mediated transport|protein secretion|ubiquitin-dependent protein catabolic process	ubiquitin binding|SNARE binding|aspartic-type endopeptidase activity	plasma membrane
YOL076W	YOL076W	MDM20	hom	Verified	0.621232182095412	0.267223433884776	no	1261	0.310162307266115	1074	NA	FF|FT	MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION			Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly	mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization	peptide alpha-N-acetyltransferase activity	NatB complex
YDR368W	YDR368W	YPR1	hom	Verified	0.621091841718864	0.267269598383495	no	1262	0.264828552638112	919	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YPL208W	YPL208W	RKM1	hom	Verified	0.620164978850007	0.267574587855364	no	1263	0.26617026085569	907	NA	FT		NUCLEUS		SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)	peptidyl-lysine dimethylation	protein-lysine N-methyltransferase activity	nucleus|cytoplasm
YBR111W-A	YBR111W-A	SUS1	hom	Verified	0.619686552973575	0.267732085227615	no	1264	0.331167159661212	1093	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE|HISTONE ACETYLTRANSFERASE	Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP	poly(A)+ mRNA export from nucleus|regulation of protein localization|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone deubiquitination|histone H3-K4 methylation|transcription elongation from RNA polymerase II promoter|histone H3-K79 methylation|positive regulation of transcription from RNA polymerase II promoter	enzyme activator activity	DUBm complex|nucleoplasm|transcription export complex 2|SAGA complex|nuclear pore
YMR056C	YMR056C	AAC1	hom	Verified	0.619512384247041	0.267789433013592	no	1265	0.25680126864929	894	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	heme biosynthetic process|mitochondrial transport|heme transport|aerobic respiration	ATP:ADP antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YKL093W	YKL093W	MBR1	hom	Verified	0.619347683610399	0.267843668975121	no	1266	0.258538322805573	927	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants	aerobic respiration	molecular_function	cellular_component
YDL009C_p	YDL009C	YDL009C	hom	Uncharacterized	0.618802267011013	0.26802331429319	no	1267	0.265286503760472	902	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene	biological_process	molecular_function	cellular_component
YGR144W	YGR144W	THI4	hom	Verified	0.618553171559875	0.268105379699393	no	1268	0.288626176473166	984	NA	FT	MITOCHONDRION ORGANIZATION	NUCLEUS		Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents	thiamine biosynthetic process|mitochondrial genome maintenance|thiazole biosynthetic process	ferrous iron binding	cytosol
YER032W	YER032W	FIR1	hom	Verified	0.618496318846411	0.268124111806062	no	1269	0.293583436418083	986	NA	FT	RNA PROCESSING	SITE OF POLARIZED GROWTH		Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate	mRNA polyadenylation|RNA polyadenylation	molecular_function	cellular bud neck
YLR395C	YLR395C	COX8	hom	Verified	0.618235596876513	0.268210024176316	no	1270	0.282509709439587	980	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YIL037C	YIL037C	PRM2	hom	Verified	0.616928318723365	0.268641003533782	no	1271	0.27411813438919	943	NA					Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion	karyogamy involved in conjugation with cellular fusion	molecular_function	integral to membrane
YPR150W_d	YPR150W	YPR150W	hom	Dubious	0.616745238070339	0.268701388758009	no	1272	0.239944664070812	815	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C	Unknown	Unknown	Unknown
YPL099C	YPL099C	AIM43	hom	Verified	0.61518981683984	0.269214685992839	no	1273	0.256631537342164	852	NA	FT		MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YKL096W-A	YKL096W-A	CWP2	hom	Verified	0.613479501463432	0.269779666323378	no	1274	0.271100101519791	939	NA	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored	fungal-type cell wall organization|regulation of pH	structural constituent of cell wall	fungal-type cell wall
YAL042W	YAL042W	ERV46	hom	Verified	0.61275691035975	0.270018543136576	no	1275	0.28346492176442	949	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YKL170W	YKL170W	MRPL38	hom	Verified	0.612026051068652	0.270260260891382	no	1276	0.28352047978533	982	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDR538W	YDR538W	PAD1	hom	Verified	0.612023649626933	0.270261055300675	no	1277	0.259508966634183	894	NA	FT	KETONE METABOLISM	MITOCHONDRION		Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX	cinnamic acid catabolic process|aromatic compound catabolic process	mRNA binding|carboxy-lyase activity	mitochondrion
YJL123C	YJL123C	MTC1	hom	Verified	0.611268105276939	0.270511051220002	no	1278	0.270400619500352	947	NA	FT		GOLGI APPARATUS		Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1	biological_process	molecular_function	COPI-coated vesicle|ribosome|Golgi apparatus|cytoplasm
YLL040C	YLL040C	VPS13	hom	Verified	0.610769722917749	0.27067602012071	no	1279	0.26161525236481	888	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	MITOCHONDRION|GOLGI APPARATUS		Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively	protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole|ascospore-type prospore membrane assembly	molecular_function	endosome|mitochondrion|prospore membrane|extrinsic to membrane
YKR040C_d	YKR040C	YKR040C	hom	Dubious	0.610158475670319	0.270878416851764	no	1280	0.263818136487233	916	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W	Unknown	Unknown	Unknown
YMR040W	YMR040W	YET2	hom	Verified	0.609992917461432	0.27093324962882	no	1281	0.282298308811607	937	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein	biological_process	molecular_function	ribosome|integral to membrane
YDL192W	YDL192W	ARF1	hom	Verified	0.609387762833047	0.271133723578446	no	1282	0.297495213820395	997	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|intra-Golgi vesicle-mediated transport|macroautophagy	GTPase activity	cytosol|Golgi-associated vesicle
YDR079C-A	YDR079C-A	TFB5	hom	Verified	0.609250422011668	0.271179231762173	no	1283	0.269786962181862	960	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS	RNA POL II, HOLOENZYME	Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleus
YJR052W	YJR052W	RAD7	hom	Verified	0.608772071223414	0.271337764075408	no	1284	0.270768035573723	917	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	damaged DNA binding|ubiquitin-protein ligase activity|DNA-dependent ATPase activity	nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YCR028C-A	YCR028C-A	RIM1	hom	Verified	0.608692328987942	0.271364196286855	no	1285	0.31134766181833	1056	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication	mitochondrial DNA replication|mitochondrial genome maintenance	single-stranded DNA binding	mitochondrial nucleoid|mitochondrion
YPL246C	YPL246C	RBD2	hom	Verified	0.608464290639626	0.271439791389029	no	1286	0.256167937151435	891	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p	biological_process	molecular_function	COPI-coated vesicle|integral to membrane|Golgi apparatus
YNR005C_d	YNR005C	YNR005C	hom	Dubious	0.607303567373126	0.271824735666986	no	1287	0.285253336453166	1007	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR130C	YJR130C	STR2	hom	Verified	0.606949488275887	0.271942217120631	no	1288	0.264131561042642	903	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Cystathionine gamma-synthase, converts cysteine into cystathionine	sulfur compound metabolic process|transsulfuration	cystathionine gamma-synthase activity	nucleus|cytoplasm
YEL051W	YEL051W	VMA8	hom	Verified	0.606863388922944	0.271970788218711	no	1289	0.298034323035215	1015	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YPL048W	YPL048W	CAM1	hom	Verified	0.606700800906602	0.272024745287336	no	1290	0.277332851081056	972	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS		Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma	ribosome biogenesis|positive regulation of transcription from RNA polymerase II promoter	phospholipid binding|transcription coactivator activity|calcium ion binding	nucleus
YPL113C_p	YPL113C	YPL113C	hom	Uncharacterized	0.606207018819147	0.272188646287717	no	1291	0.241218477610951	848	NA	FT	OXIDATION-REDUCTION PROCESS			Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene	metabolic process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	cellular_component
YDL185W	YDL185W	VMA1	hom	Verified	0.604984759538024	0.272594561593659	no	1292	0.338898434304751	1152	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM		Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease	intron homing|cellular protein metabolic process|vacuolar acidification	endodeoxyribonuclease activity|proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane
YOL086W-A	YOL086W-A	MHF1	hom	Verified	0.604611131339418	0.272718704375207	no	1293	0.242351458606529	851	NA	FT	RESPONSE TO DNA DAMAGE			Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1	response to DNA damage stimulus	molecular_function	cellular_component
YDR377W	YDR377W	ATP17	hom	Verified	0.603595609389722	0.273056266306606	no	1294	0.292192959550927	980	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YKR046C	YKR046C	PET10	hom	Verified	0.602935364285402	0.273275844404369	no	1295	0.267315290929994	915	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange	aerobic respiration	molecular_function	lipid particle
YDL036C	YDL036C	PUS9	hom	Verified	0.602897519510065	0.273288433113142	no	1296	0.254778170294715	842	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|nucleus|cytoplasm
YLR168C	YLR168C	UPS2	hom	Verified	0.602755002560946	0.273335842614044	no	1297	0.275132733150967	952	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI	cristae formation|Unknown|phosphatidylethanolamine metabolic process|cardiolipin metabolic process	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YBR028C	YBR028C	YPK3	hom	Verified	0.602416342976209	0.273448517002976	no	1298	0.305070713906655	1015	NA	FT	PROTEIN PHOSPHORYLATION			An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner	biological_process	protein kinase activity	cytoplasm
YCL016C	YCL016C	DCC1	hom	Verified	0.601787293609329	0.273657867087208	no	1299	0.2900394476285	982	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	CHROMOSOME		Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance	maintenance of DNA trinucleotide repeats|response to DNA damage stimulus|mitotic sister chromatid cohesion	molecular_function	Ctf18 RFC-like complex
YJL176C	YJL176C	SWI3	hom	Verified	0.600120200619991	0.274213065390619	no	1300	0.29874305171885	1045	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	histone binding|DNA binding	SWI/SNF complex|nucleus
YLR014C	YLR014C	PPR1	hom	Verified	0.599584022003022	0.274391749148494	no	1301	0.306672847270016	1031	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding|zinc ion binding	nucleus
YAL019W	YAL019W	FUN30	hom	Verified	0.596082651671705	0.27556000651052	no	1302	0.271162785733711	903	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|MITOCHONDRION|CHROMOSOME		Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate	chromosome organization|chromatin silencing at rDNA|heterochromatin maintenance involved in chromatin silencing|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|heterochromatin assembly involved in chromatin silencing	chromatin binding|DNA-dependent ATPase activity|DNA binding|protein homodimerization activity	mitochondrion|mating-type region heterochromatin|nucleus
YOL136C	YOL136C	PFK27	hom	Verified	0.595283483350457	0.275826997224752	no	1303	0.25750637187897	883	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YDL219W	YDL219W	DTD1	hom	Verified	0.594690433470263	0.276025208840712	no	1304	0.253785608689214	877	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes	Unknown	D-leucyl-tRNA(Leu) deacylase activity|D-tyrosyl-tRNA(Tyr) deacylase activity	cytoplasm
YER075C	YER075C	PTP3	hom	Verified	0.59443641732039	0.276110128572534	no	1305	0.257600397019734	901	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm	inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of sporulation|regulation of protein localization|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion	protein tyrosine phosphatase activity	nucleus|cytoplasm
YGL210W	YGL210W	YPT32	hom	Verified	0.592895964000697	0.276625389612172	no	1306	0.245236679116661	852	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication	early endosome to Golgi transport|vesicle-mediated transport|exocytosis	GTPase activity	endosome|mitochondrial outer membrane|Golgi apparatus
YLR214W	YLR214W	FRE1	hom	Verified	0.592783730085762	0.276662948766689	no	1307	0.250990364724948	845	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YMR201C	YMR201C	RAD14	hom	Verified	0.591297638255263	0.277160505875528	no	1308	0.284209126212831	987	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein	nucleotide-excision repair, DNA damage recognition	damaged DNA binding|zinc ion binding	nucleotide-excision repair factor 1 complex|nucleus
YOR226C	YOR226C	ISU2	hom	Verified	0.59124843680532	0.277176986454534	no	1309	0.269427317187584	940	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved	cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification	molecular_function	mitochondrial matrix
YOR172W	YOR172W	YRM1	hom	Verified	0.590958031405019	0.277274270774686	no	1310	0.277119708148059	943	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|nucleic acid binding transcription factor activity	nucleus|cytoplasm
YMR182W-A_p	YMR182W-A	YMR182W-A	hom	Uncharacterized	0.590532734287348	0.277416773258991	no	1311	0.244894463391486	845	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR060C	YMR060C	SAM37	hom	Verified	0.590107634173636	0.277559245503419	no	1312	0.32089169169216	1097	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability	mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to membrane
YOR277C_d	YOR277C	YOR277C	hom	Dubious	0.588736217348302	0.27801911924449	no	1313	0.296715167006991	1061	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20	Unknown	Unknown	Unknown
YDR231C	YDR231C	COX20	hom	Verified	0.587554294317181	0.278415748542418	no	1314	0.280277252919118	945	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase	mitochondrial respiratory chain complex IV assembly|protein processing|aerobic respiration	unfolded protein binding	mitochondrion|mitochondrial inner membrane
YLR201C	YLR201C	COQ9	hom	Verified	0.586588621874133	0.278740013088767	no	1315	0.271222728084504	924	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes	ubiquinone biosynthetic process|aerobic respiration	molecular_function	mitochondrion|mitochondrial inner membrane
YFR035C_p	YFR035C	YFR035C	hom	Uncharacterized	0.585603616558739	0.279070958733728	no	1316	0.266035251587498	903	NA					Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein	biological_process	molecular_function	cellular_component
YNL080C	YNL080C	EOS1	hom	Verified	0.585203789632973	0.279205348527029	no	1317	0.29622213129937	998	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene	cellular response to oxidative stress|protein N-linked glycosylation	molecular_function	integral to membrane|endoplasmic reticulum membrane
YLR137W	YLR137W	RKM5	hom	Verified	0.584230100364683	0.279532756400872	no	1318	0.259380406629738	898	NA					Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species	protein methylation	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YOL080C	YOL080C	REX4	hom	Verified	0.58337800822192	0.279819429497296	no	1319	0.259932000457978	886	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly	ribosomal large subunit assembly|rRNA processing	3'-5' exonuclease activity	nucleolus|nucleus
YJL207C	YJL207C	LAA1	hom	Verified	0.581988192935949	0.280287316933142	no	1320	0.2829628785003	968	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene	protein localization|retrograde transport, endosome to Golgi	molecular_function	AP-1 adaptor complex|ribosome|clathrin-coated vesicle
YPL037C	YPL037C	EGD1	hom	Verified	0.581791805199295	0.280353462272574	no	1321	0.290249769441194	957	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b	'de novo' cotranslational protein folding	unfolded protein binding	nascent polypeptide-associated complex
YOR033C	YOR033C	EXO1	hom	Verified	0.579141099478414	0.281246985039446	no	1322	0.281083559735339	950	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress	mismatch repair|telomeric 3' overhang formation|DNA double-strand break processing|meiotic DNA double-strand break processing|telomere maintenance|gene conversion at mating-type locus, DNA double-strand break processing	5'-3' exonuclease activity|5'-flap endonuclease activity	nucleus
YDR216W	YDR216W	ADR1	hom	Verified	0.578359363342127	0.28151076170905	no	1323	0.296548973168032	998	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING|PEROXISOME ORGANIZATION	NUCLEUS		Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization	negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|chromatin organization|regulation of transcription by chromatin organization|positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|peroxisome organization|positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|TFIIB-class transcription factor binding|sequence-specific DNA binding|TFIID-class transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	nucleus
YDR085C	YDR085C	AFR1	hom	Verified	0.577637873085746	0.281754315816367	no	1324	0.277083220101276	936	NA	FT	SIGNALING			Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication	regulation of G-protein coupled receptor protein signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation	receptor signaling protein activity	mating projection base
YLR122C_d	YLR122C	YLR122C	hom	Dubious	0.577228307465549	0.281892618426351	no	1325	0.290079365635965	964	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C	Unknown	Unknown	Unknown
YDR445C_d	YDR445C	YDR445C	hom	Dubious	0.575848376338608	0.282358835828185	no	1326	0.305218768186004	1042	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAR002W	YAR002W	NUP60	hom	Verified	0.575349754767108	0.282527389082976	no	1327	0.29627918323044	992	NA	FT	PROTEIN LOCALIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153	double-strand break repair|poly(A)+ mRNA export from nucleus|protein export from nucleus|regulation of protein desumoylation|intracellular mRNA localization|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|chromosome organization|nucleocytoplasmic transport|chromatin silencing at silent mating-type cassette	nucleocytoplasmic transporter activity|phospholipid binding|structural constituent of nuclear pore	nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YPR046W	YPR046W	MCM16	hom	Verified	0.575107877612816	0.282609170279027	no	1328	0.323999875005885	1110	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YFR001W	YFR001W	LOC1	hom	Verified	0.575016177343297	0.282640178073802	no	1329	0.305754100521081	1051	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; relocalizes from nucleus to cytoplasm upon DNA replication stress	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|intracellular mRNA localization	mRNA binding	nucleolus|preribosome, large subunit precursor
YJL016W_p	YJL016W	YJL016W	hom	Uncharacterized	0.57127617157959	0.283906225721346	no	1330	0.288488657665389	977	NA					Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species	biological_process	molecular_function	cytoplasm
YML111W	YML111W	BUL2	hom	Verified	0.569532387632954	0.284497448898953	no	1331	0.273405984098056	938	NA	FT			UBIQUITIN LIGASE COMPLEX	Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication	protein polyubiquitination|protein monoubiquitination	ubiquitin-ubiquitin ligase activity	ubiquitin ligase complex|cytoplasm
YLR331C_d	YLR331C	JIP3	hom	Dubious	0.569501935950473	0.284507778646195	no	1332	0.28260842181152	977	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2	Unknown	Unknown	Unknown
YDR477W	YDR477W	SNF1	hom	Verified	0.569278575962889	0.284583551765077	no	1333	0.281618758747871	921	NA	FT	KETONE METABOLISM|SIGNALING|TRANSLATION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation	negative regulation of translation|protein phosphorylation|replicative cell aging|signal transduction|biofilm formation|positive regulation of gluconeogenesis|pseudohyphal growth|cell adhesion|regulation of carbohydrate metabolic process|invasive growth in response to glucose limitation|cellular response to nitrogen starvation	AMP-activated protein kinase activity|protein kinase activity	mitochondrion|AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|fungal-type vacuole|cytoplasm
YPL005W	YPL005W	AEP3	hom	Verified	0.568067256704018	0.284994650050743	no	1334	0.275304712982875	938	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA	mRNA metabolic process|mitochondrial translational initiation	molecular_function	mitochondrion|mitochondrial inner membrane|cytoplasm|extrinsic to membrane
YML034W	YML034W	SRC1	hom	Verified	0.567384658548125	0.285226435326377	no	1335	0.314690487432569	1085	NA	FF|FT	CELL CYCLE|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance	maintenance of rDNA|mitotic sister chromatid segregation	molecular_function	nuclear envelope
YHR075C	YHR075C	PPE1	hom	Verified	0.567211578472334	0.285285221238801	no	1336	0.282810300019964	943	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein	cellular protein modification process|mitochondrial translation	structural constituent of ribosome|carboxylesterase activity	mitochondrial small ribosomal subunit
YPL074W	YPL074W	YTA6	hom	Verified	0.56624712206255	0.285612900411917	no	1337	0.238059771359653	828	NA					Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress	biological_process	ATPase activity	cell cortex
YEL043W	YEL043W	YEL043W	hom	Verified	0.564863054815039	0.28608345729819	no	1338	0.28392540989809	989	NA	FT		ENDOPLASMIC RETICULUM		Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold	biological_process	molecular_function	ribosome|endoplasmic reticulum
YDL237W	YDL237W	AIM6	hom	Verified	0.563071116071376	0.286693229439501	no	1339	0.291238826832499	987	NA					Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene	biological_process	molecular_function	cellular_component
YPL180W	YPL180W	TCO89	hom	Verified	0.562999703184786	0.286717543027426	no	1340	0.303952307258232	1061	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin	TOR signaling cascade|fungal-type cell wall organization|response to salt stress|regulation of cell growth|glycerol metabolic process	molecular_function	TORC1 complex|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|extrinsic to vacuolar membrane
YDR319C_p	YDR319C	YFT2	hom	Uncharacterized	0.56286623040737	0.286762988456553	no	1341	0.282317839755005	975	NA					Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens	biological_process	molecular_function	integral to membrane
YGR224W	YGR224W	AZR1	hom	Verified	0.562801487110641	0.286785033783733	no	1342	0.265111468584737	920	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole	azole transport	azole transporter activity	integral to membrane|plasma membrane
YNL115C_p	YNL115C	YNL115C	hom	Uncharacterized	0.561883335091292	0.287097754316284	no	1343	0.276062965125011	940	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YKL032C	YKL032C	IXR1	hom	Verified	0.561439130212852	0.287249107441618	no	1344	0.330505474855532	1118	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b	DNA repair|cellular response to hypoxia|negative regulation of transcription from RNA polymerase II promoter	damaged DNA binding|sequence-specific DNA binding	nuclear chromatin
YCR061W_p	YCR061W	YCR061W	hom	Uncharacterized	0.559808211682001	0.287805130959403	no	1345	0.292248942946424	993	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation	regulation of cell size	molecular_function	integral to membrane|cytoplasm
YJL096W	YJL096W	MRPL49	hom	Verified	0.559566742188647	0.287887497522986	no	1346	0.307697205324543	1031	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YJR139C	YJR139C	HOM6	hom	Verified	0.557652003720584	0.28854101904633	no	1347	0.305287257087729	1062	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions	threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process	homoserine dehydrogenase activity	nucleus|cytoplasm
YKL218C	YKL218C	SRY1	hom	Verified	0.556029775588076	0.289095249940627	no	1348	0.281640263046479	933	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity	cellular modified amino acid catabolic process	serine racemase activity|threo-3-hydroxyaspartate ammonia-lyase activity	cellular_component
YAL053W	YAL053W	FLC2	hom	Verified	0.555208047245419	0.289376182634492	no	1349	0.308248837508356	1040	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication	protein folding|fungal-type cell wall biogenesis|FAD transport|transmembrane transport	FAD transmembrane transporter activity	integral to membrane|endoplasmic reticulum|cytoplasm
YGL190C	YGL190C	CDC55	hom	Verified	0.554921983118764	0.289474012400208	no	1350	0.389763479431068	1302	NA	FT	CELL CYCLE|SIGNALING	NUCLEUS|SITE OF POLARIZED GROWTH		Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion	negative regulation of exit from mitosis|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|protein dephosphorylation	protein phosphatase type 2A regulator activity	nucleus|cellular bud neck|cytoplasm|cellular bud tip
YHR151C	YHR151C	MTC6	hom	Verified	0.553799408882506	0.289858066447934	no	1351	0.293552616158638	1029	NA					Protein of unknown function; mtc6 is synthetically sick with cdc13-1	biological_process	molecular_function	cellular_component
YOR183W_p	YOR183W	FYV12	hom	Uncharacterized	0.553564275941914	0.289938540172862	no	1352	0.283135806351479	976	NA					Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	cellular_component
YEL059W_d	YEL059W	HHY1	hom	Dubious	0.552641183877572	0.290254567630618	no	1353	0.277001097580255	915	NA					Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking	Unknown	Unknown	Unknown
YGR255C	YGR255C	COQ6	hom	Verified	0.552148175645904	0.29042341875226	no	1354	0.292714355532225	1002	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)	ubiquinone biosynthetic process	N,N-dimethylaniline monooxygenase activity	mitochondrion|mitochondrial inner membrane
YOL110W	YOL110W	SHR5	hom	Verified	0.550786962147499	0.29088986138195	no	1355	0.290836891383284	996	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization	protein targeting to membrane|protein palmitoylation	palmitoyltransferase activity	endoplasmic reticulum palmitoyltransferase complex|extrinsic to endoplasmic reticulum membrane
YOR134W	YOR134W	BAG7	hom	Verified	0.550413357119844	0.291017944621102	no	1356	0.287233702844865	1004	NA	FT	SIGNALING			Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p	small GTPase mediated signal transduction	Rho GTPase activator activity	intracellular
YER056C-A	YER056C-A	RPL34A	hom	Verified	0.550249433862181	0.291074150846378	no	1357	0.253496162838096	890	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR266C_d	YBR266C	SLM6	hom	Dubious	0.549798305520649	0.29122886050688	no	1358	0.29945768345078	995	NA					Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase	Unknown	Unknown	Unknown
YDR379C-A	YDR379C-A	YDR379C-A	hom	Verified	0.549228116112422	0.29142445579612	no	1359	0.299703424016306	1037	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy	mitochondrial respiratory chain complex II assembly	molecular_function	mitochondrion
YMR226C	YMR226C	YMR226C	hom	Verified	0.549146316840098	0.291452520887798	no	1360	0.285615891643587	998	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments	metabolic process	oxidoreductase activity|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|carbonyl reductase (NADPH) activity	integral to membrane|ribosome|nucleus|cytoplasm
YLR073C	YLR073C	RFU1	hom	Verified	0.549019104115821	0.291496169707173	no	1361	0.31040557815964	1054	NA					Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes	regulation of ubiquitin homeostasis	enzyme inhibitor activity	endosome
YMR175W	YMR175W	SIP18	hom	Verified	0.548385421701182	0.29171364217854	no	1362	0.27090754711394	934	NA					Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress	cellular response to water deprivation	phospholipid binding	cytoplasm
YJL004C	YJL004C	SYS1	hom	Verified	0.548278235903527	0.291750434579365	no	1363	0.325502163349864	1129	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation	vesicle organization|Golgi to plasma membrane protein transport|Golgi to endosome transport	molecular_function	trans-Golgi network|integral to membrane|integral to Golgi membrane
YOL075C_p	YOL075C	YOL075C	hom	Uncharacterized	0.54814910880819	0.291794761381371	no	1364	0.256904475407105	853	NA	FT	NUCLEOTIDE METABOLISM			Putative ABC transporter	transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YDR441C	YDR441C	APT2	hom	Verified	0.54810112541842	0.291811233938621	no	1365	0.286394256887851	953	NA					Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication	biological_process	adenine phosphoribosyltransferase activity|molecular_function	cytoplasm
YLR418C	YLR418C	CDC73	hom	Verified	0.548026501672748	0.291836852912854	no	1366	0.402808986084919	1329	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress	transcription elongation from RNA polymerase I promoter|negative regulation of DNA recombination|mRNA 3'-end processing|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair|transcription elongation from RNA polymerase II promoter	chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YGR168C_p	YGR168C	YGR168C	hom	Uncharacterized	0.547979037783022	0.291853148219891	no	1367	0.3238964589639	1120	NA					Putative protein of unknown function; YGR168C is not an essential gene	biological_process	molecular_function	integral to membrane
YDR204W	YDR204W	COQ4	hom	Verified	0.547265236600844	0.292098261609104	no	1368	0.281164576796181	988	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex	ubiquinone biosynthetic process	molecular_function	mitochondrial inner membrane
YOR118W	YOR118W	RTC5	hom	Verified	0.547252887957845	0.292102502873386	no	1369	0.313682455539969	1074	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity	biological_process	molecular_function	cytoplasm
YIL102C_p	YIL102C	YIL102C	hom	Uncharacterized	0.546520412719271	0.292354130037202	no	1370	0.278791722131329	928	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJL048C	YJL048C	UBX6	hom	Verified	0.546133759707411	0.292486997551747	no	1371	0.28141552083968	956	NA	FT	PROTEOLYSIS	NUCLEUS		UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication	sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process	molecular_function	nucleus
YLR319C	YLR319C	BUD6	hom	Verified	0.545701983934301	0.292635403989329	no	1372	0.305013542929705	1030	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate	bipolar cellular bud site selection|positive regulation of formin-nucleated actin cable assembly|cellular bud site selection|Rho protein signal transduction|extrachromosomal circular DNA localization involved in cell aging|establishment of cell polarity|response to osmotic stress|cytokinesis	cytoskeletal regulatory protein binding	polarisome|actin cap|spindle pole body|mating projection tip
YHR016C	YHR016C	YSC84	hom	Verified	0.545197408366974	0.29280887688894	no	1373	0.297417658451867	996	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication	endocytosis|actin filament organization|actin filament bundle assembly|actin cortical patch localization|actin cytoskeleton organization	actin filament binding	actin cortical patch
YOR304C-A_p	YOR304C-A	YOR304C-A	hom	Uncharacterized	0.543699032402656	0.293324299196204	no	1374	0.30406702658602	1022	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck	biological_process	molecular_function	cellular bud|mating projection tip|cellular bud neck|cytoplasm
YNL226W_d	YNL226W	YNL226W	hom	Dubious	0.543633242716369	0.293346939645872	no	1375	0.291115633764875	983	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C	Unknown	Unknown	Unknown
YOR038C	YOR038C	HIR2	hom	Verified	0.543561419903262	0.293371657222482	no	1376	0.286502556486048	975	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p	DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter	nucleosome binding|transcription corepressor activity|DNA binding	HIR complex|nucleus
YLR426W_p	YLR426W	TDA5	hom	Uncharacterized	0.542902078269229	0.293598612481312	no	1377	0.343146726257246	1144	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele	response to drug	molecular_function	mitochondrion|integral to membrane
YKR024C	YKR024C	DBP7	hom	Verified	0.542860027239282	0.293613089832302	no	1378	0.296476877576063	1009	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus
YPR119W	YPR119W	CLB2	hom	Verified	0.542823899352541	0.293625528224336	no	1379	0.307579175769384	1076	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|spindle pole body|cellular bud neck|spindle|cytoplasm
YNL070W	YNL070W	TOM7	hom	Verified	0.542736342411676	0.293655674026182	no	1380	0.314606138706256	1070	NA	FF|FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex	protein import into mitochondrial matrix|protein import into mitochondrial outer membrane	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YDL117W	YDL117W	CYK3	hom	Verified	0.542128855999291	0.293864870672718	no	1381	0.288532421040045	981	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants	barrier septum assembly involved in cell cycle cytokinesis|cytokinesis	molecular_function	cellular bud neck contractile ring|cellular bud neck|cytoplasm
YPL152W	YPL152W	RRD2	hom	Verified	0.541957554431052	0.293923873278457	no	1382	0.276542549875348	955	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION			Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress	mitotic spindle organization in nucleus|response to osmotic stress	peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity	protein phosphatase type 2A complex
YDR144C	YDR144C	MKC7	hom	Verified	0.541853730196497	0.293959636857161	no	1383	0.301211607498973	1028	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	PLASMA MEMBRANE		GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p	proteolysis|fungal-type cell wall organization	aspartic-type endopeptidase activity	fungal-type cell wall
YKR031C	YKR031C	SPO14	hom	Verified	0.541310062893084	0.294146942824347	no	1384	0.290935395907507	986	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM	NUCLEUS		Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions	phospholipid metabolic process|exocytosis|cell morphogenesis involved in conjugation with cellular fusion|ascospore-type prospore assembly	phospholipase D activity|phosphatidylinositol-3-phosphate binding	endosome|nucleus|prospore membrane
YKL025C	YKL025C	PAN3	hom	Verified	0.541192419112556	0.294187481086111	no	1385	0.32491373114827	1101	NA	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION			Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes	DNA repair|mRNA 3'-end processing|postreplication repair	poly(A)-specific ribonuclease activity	PAN complex|cytoplasm
YMR272C	YMR272C	SCS7	hom	Verified	0.539794504612741	0.29466937865558	no	1386	0.311534720081839	1071	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth	inositolphosphoceramide metabolic process	fatty acid alpha-hydroxylase activity	integral to membrane|endoplasmic reticulum|membrane
YIL136W	YIL136W	OM45	hom	Verified	0.539159762521582	0.294888310928696	no	1387	0.300056935752712	993	NA	FT		MITOCHONDRION		Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YDR529C	YDR529C	QCR7	hom	Verified	0.538601618402598	0.295080885307999	no	1388	0.31748882301682	1056	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration|mitochondrial respiratory chain complex III assembly	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YDR014W	YDR014W	RAD61	hom	Verified	0.537775556762267	0.295366004515438	no	1389	0.313581763763307	1064	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin	mitotic sister chromatid cohesion	molecular_function	nuclear cohesin complex
YDR115W	YDR115W	YDR115W	hom	Verified	0.537605365629017	0.29542476255978	no	1390	0.299221851009458	994	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrial large ribosomal subunit
YOR382W	YOR382W	FIT2	hom	Verified	0.537117191240159	0.295593333316727	no	1391	0.259728340379296	875	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall	siderophore transport	molecular_function	fungal-type cell wall
YNL213C	YNL213C	RRG9	hom	Verified	0.536484008010474	0.295812042705278	no	1392	0.307358559985811	1044	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	mitochondrion organization|mitochondrial genome maintenance	molecular_function	mitochondrion
YDL085C-A_p	YDL085C-A	YDL085C-A	hom	Uncharacterized	0.536452565646954	0.295822905227058	no	1393	0.301862107997571	1030	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YKR070W_p	YKR070W	YKR070W	hom	Uncharacterized	0.535721018304924	0.2960756875827	no	1394	0.288265862972904	957	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPL193W	YPL193W	RSA1	hom	Verified	0.535571937249908	0.29612721391805	no	1395	0.327507648551899	1116	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly	ribosomal large subunit assembly	molecular_function	nucleoplasm
YJL037W	YJL037W	IRC18	hom	Verified	0.535432753583589	0.296175323169026	no	1396	0.302105437920685	1061	NA					Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YGR239C	YGR239C	PEX21	hom	Verified	0.535412416680517	0.296182352980692	no	1397	0.313769384293349	1069	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress	protein import into peroxisome matrix|positive regulation of protein binding	protein binding	cytosol|peroxisome
YGR180C	YGR180C	RNR4	hom	Verified	0.535360799131044	0.296200195846924	no	1398	0.332508733619107	1100	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress	cofactor biosynthetic process|deoxyribonucleotide biosynthetic process	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ribonucleoside-diphosphate reductase complex|nucleus|cytoplasm
YIL035C	YIL035C	CKA1	hom	Verified	0.535128390979321	0.296280539506384	no	1399	0.292659322118361	1001	NA	FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching	regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase activity|protein kinase activity	protein kinase CK2 complex|UTP-C complex
YPL008W	YPL008W	CHL1	hom	Verified	0.533931499364178	0.296694463947337	no	1400	0.304399155198637	1039	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS		Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome	negative regulation of DNA recombination|chromosome segregation|donor selection|DNA replication initiation|mitotic sister chromatid cohesion	DNA helicase activity	nucleus
YMR243C	YMR243C	ZRC1	hom	Verified	0.53374175512304	0.296760108049525	no	1401	0.299295364688109	1016	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication	cobalt ion transport|cellular zinc ion homeostasis|zinc ion transport|glutathione metabolic process	zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity	integral to membrane|fungal-type vacuole
YNL064C	YNL064C	YDJ1	hom	Verified	0.533685535748294	0.296779559035914	no	1402	0.237083894573589	829	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION			Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family	protein refolding|ER-associated protein catabolic process|protein targeting to mitochondrion|protein targeting to ER|'de novo' protein folding	unfolded protein binding|ATPase activator activity	cytosol|TRC complex|perinuclear region of cytoplasm
YER047C	YER047C	SAP1	hom	Verified	0.530988517697875	0.297713368026537	no	1403	0.31651096747257	1068	NA					Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system	biological_process	ATPase activity	cytoplasm
YJL022W_d	YJL022W	YJL022W	hom	Dubious	0.529553266648081	0.298210851758276	no	1404	0.306837251675766	1031	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130	Unknown	Unknown	Unknown
YHR192W	YHR192W	LNP1	hom	Verified	0.529292086211209	0.298301422278573	no	1405	0.345255275708225	1154	NA					Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS	endoplasmic reticulum tubular network organization	molecular_function	endoplasmic reticulum tubular network|cytoplasm
YMR315W	YMR315W	YMR315W	hom	Verified	0.529125557501559	0.298359176601489	no	1406	0.304120142294231	1050	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress	NADPH regeneration	oxidoreductase activity	nucleus|cytoplasm
YPR097W	YPR097W	YPR097W	hom	Verified	0.528977286982696	0.298410603029189	no	1407	0.316597675303121	1078	NA	FT		MITOCHONDRION		Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	phosphatidylinositol binding	mitochondrion
YJR122W	YJR122W	IBA57	hom	Verified	0.528797979214396	0.29847279986374	no	1408	0.334158671611965	1140	NA	FF|FT	COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system	iron-sulfur cluster assembly	molecular_function	mitochondrion|mitochondrial matrix
YGL050W	YGL050W	TYW3	hom	Verified	0.528620157532429	0.298534487041154	no	1409	0.297852485431938	1003	NA	FT	RNA PROCESSING			tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions	tRNA methylation|wybutosine biosynthetic process	tRNA methyltransferase activity	cellular_component
YGR269W_d	YGR269W	YGR269W	hom	Dubious	0.527279338613352	0.298999810039449	no	1410	0.322151375600371	1087	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C	Unknown	Unknown	Unknown
YDR393W	YDR393W	SHE9	hom	Verified	0.527057949165316	0.299076673563529	no	1411	0.327177644856577	1117	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex	mitochondrion organization|inner mitochondrial membrane organization	molecular_function	mitochondrial inner membrane
YHL002W	YHL002W	HSE1	hom	Verified	0.526930179478828	0.299121037611599	no	1412	0.308827315705517	1036	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes	late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding	endosome|ESCRT-0 complex
YNL259C	YNL259C	ATX1	hom	Verified	0.526742690502822	0.299186142731977	no	1413	0.309437200554206	1067	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS			Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake	copper ion transport|cellular response to oxidative stress|cellular iron ion homeostasis	copper chaperone activity	cytosol
YGR054W	YGR054W	YGR054W	hom	Verified	0.526599030893688	0.299236032555488	no	1414	0.293279594974479	1019	NA	FT	TRANSLATION			Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A	translational initiation	translation initiation factor activity	cytosolic ribosome|cytosolic small ribosomal subunit|ribosome
YBR280C	YBR280C	SAF1	hom	Verified	0.526338162723412	0.299326635984307	no	1415	0.301535218717531	1025	NA	FT	PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	SCF ubiquitin ligase complex
YHR064C	YHR064C	SSZ1	hom	Verified	0.52625487270165	0.299355566478741	no	1416	0.257649369872793	923	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION			Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP	cytoplasmic translation|regulation of translational fidelity|rRNA processing	unfolded protein binding	polysome|cytoplasm
YOR368W	YOR368W	RAD17	hom	Verified	0.525741148074565	0.2995340349372	no	1417	0.30256333691297	1025	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins	double-strand break repair|reciprocal meiotic recombination|DNA damage checkpoint	double-stranded DNA binding	nucleus|checkpoint clamp complex
YBR026C	YBR026C	ETR1	hom	Verified	0.525690702918093	0.299551562235796	no	1418	0.328685648321913	1077	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis	fatty acid biosynthetic process|aerobic respiration	enoyl-[acyl-carrier-protein] reductase activity	mitochondrion
YBR189W	YBR189W	RPS9B	hom	Verified	0.525537434070717	0.299604818740082	no	1419	0.288480557854993	978	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication	positive regulation of translational fidelity|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YCL005W-A	YCL005W-A	VMA9	hom	Verified	0.525046985870718	0.29977526416781	no	1420	0.329216450997949	1111	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis	cell wall mannoprotein biosynthetic process|vacuolar acidification|protein complex assembly|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions	vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane
YGL072C_d	YGL072C	YGL072C	hom	Dubious	0.524330689407175	0.300024277490452	no	1421	0.327814574031318	1100	NA	FF				Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	Unknown	Unknown	Unknown
YDL160C-A	YDL160C-A	MHF2	hom	Verified	0.523831224220724	0.300197966940274	no	1422	0.309341292946543	1047	NA	FT	RESPONSE TO DNA DAMAGE			Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2	response to DNA damage stimulus	molecular_function	cellular_component
YER066W_p	YER066W	RRT13	hom	Uncharacterized	0.523238843283322	0.300404026838309	no	1423	0.272169886574231	971	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription	biological_process	molecular_function	cellular_component
YDR300C	YDR300C	PRO1	hom	Verified	0.523154086373108	0.300433514781533	no	1424	0.304613609055908	1016	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication	proline biosynthetic process	glutamate 5-kinase activity	cytoplasm
YKR061W	YKR061W	KTR2	hom	Verified	0.523085509246059	0.300457374541568	no	1425	0.286601099665194	979	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication	cell wall mannoprotein biosynthetic process|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YBL071C_d	YBL071C	YBL071C	hom	Dubious	0.522665384046293	0.30060356566886	no	1426	0.293702064007018	973	NA					Dubious open reading frame, predicted protein contains a peroxisomal targeting signal	Unknown	Unknown	Unknown
YER183C	YER183C	FAU1	hom	Verified	0.519202102742669	0.301809906430276	no	1427	0.307683076597056	1065	NA	FT	COFACTOR METABOLISM	MITOCHONDRION		5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis	folic acid-containing compound biosynthetic process	5-formyltetrahydrofolate cyclo-ligase activity	mitochondrion
YPL223C	YPL223C	GRE1	hom	Verified	0.519009704387487	0.301876986970165	no	1428	0.318613752608749	1031	NA					Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway	biological_process	molecular_function	cytoplasm
YNL225C	YNL225C	CNM67	hom	Verified	0.517017983934186	0.302571802418332	no	1429	0.328187036796501	1124	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication	microtubule nucleation|mitotic spindle organization	structural constituent of cytoskeleton	outer plaque of spindle pole body|spindle pole body
YDR287W	YDR287W	INM2	hom	Verified	0.515935328708376	0.302949789193238	no	1430	0.309266362432681	1072	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM			Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy	inositol phosphate dephosphorylation	inositol monophosphate 1-phosphatase activity	cellular_component
YJL145W	YJL145W	SFH5	hom	Verified	0.515618098202121	0.303060583713099	no	1431	0.279514935622515	967	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress	Golgi to plasma membrane protein transport|phosphatidylinositol metabolic process|Unknown|regulation of exocytosis|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cell periphery|cytosol|plasma membrane|cortical endoplasmic reticulum
YGR146C-A_p	YGR146C-A	YGR146C-A	hom	Uncharacterized	0.514954134411253	0.303292535417344	no	1432	0.298416653913652	1007	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPR135W	YPR135W	CTF4	hom	Verified	0.514140651999372	0.303576828657924	no	1433	0.371950897017973	1236	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion	DNA repair|replicative cell aging|double-strand break repair via break-induced replication|DNA replication initiation|DNA-dependent DNA replication|mitotic sister chromatid cohesion	chromatin binding|DNA binding	nuclear chromosome|replication fork protection complex|nuclear replication fork|nucleus
YAR003W	YAR003W	SWD1	hom	Verified	0.513883556823051	0.303666702200092	no	1434	0.336930879470088	1134	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7	histone H3-K4 methylation|telomere maintenance|regulation of transcription, DNA-dependent|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YCR044C	YCR044C	PER1	hom	Verified	0.5136734536084	0.30374015743689	no	1435	0.401274491944023	1296	NA	FF|FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1	GPI anchor biosynthetic process|cellular manganese ion homeostasis	molecular_function	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YLR342W	YLR342W	FKS1	hom	Verified	0.513553145949254	0.303782222369691	no	1436	0.305368010473377	1055	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON		Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling	(1->3)-beta-D-glucan biosynthetic process|positive regulation of endocytosis|regulation of cell size	1,3-beta-D-glucan synthase activity	mitochondrion|1,3-beta-D-glucan synthase complex|integral to membrane|plasma membrane|cellular bud neck|cellular bud tip|actin cortical patch
YLR030W_p	YLR030W	YLR030W	hom	Uncharacterized	0.512892813440168	0.304013150387275	no	1437	0.281531676787307	982	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR196C-A_p	YBR196C-A	YBR196C-A	hom	Uncharacterized	0.512843792491026	0.304030296856201	no	1438	0.338822863238505	1135	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YGR230W	YGR230W	BNS1	hom	Verified	0.511188504023707	0.304609533837313	no	1439	0.295064686217974	1009	NA	FT	CELL CYCLE			Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis	meiosis	molecular_function	cellular_component
YLL010C	YLL010C	PSR1	hom	Verified	0.510520158468932	0.3048435477844	no	1440	0.318602893364319	1099	NA	FT		PLASMA MEMBRANE		Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p	response to stress	phosphoprotein phosphatase activity	plasma membrane
YBR173C	YBR173C	UMP1	hom	Verified	0.510285601597469	0.304925694264459	no	1441	0.294525512524906	982	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly	proteasome assembly|response to DNA damage stimulus|ubiquitin-dependent protein catabolic process	molecular_function	nucleus|cytoplasm
YDL238C	YDL238C	GUD1	hom	Verified	0.509818920785028	0.305089164404569	no	1442	0.303439720528961	1015	NA					Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures	guanine metabolic process	guanine deaminase activity|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	cytoplasm
YKL143W	YKL143W	LTV1	hom	Verified	0.509794975384788	0.305097553109528	no	1443	0.277252472751314	940	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature	ribosomal small subunit biogenesis|cellular response to oxidative stress|response to osmotic stress|ribosomal small subunit export from nucleus	molecular_function	preribosome, small subunit precursor|EGO complex|nucleus|late endosome membrane|cytoplasm
YDR268W	YDR268W	MSW1	hom	Verified	0.508999882332333	0.305376153296356	no	1444	0.319720826023257	1068	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial tryptophanyl-tRNA synthetase	mitochondrial tryptophanyl-tRNA aminoacylation	tryptophan-tRNA ligase activity	mitochondrion
YJR059W	YJR059W	PTK2	hom	Verified	0.508681894725199	0.305487607563821	no	1445	0.337673273599094	1146	NA	FF|FT	CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake	protein phosphorylation|cellular ion homeostasis|polyamine transport|G1/S transition of mitotic cell cycle|regulation of cell size	protein kinase activity	nucleus|plasma membrane|cytoplasm
YAL055W	YAL055W	PEX22	hom	Verified	0.50854840835778	0.305534399745741	no	1446	0.318735904162897	1077	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation	protein import into peroxisome matrix, receptor recycling|protein targeting to peroxisome	protein anchor	integral to peroxisomal membrane
YEL046C	YEL046C	GLY1	hom	Verified	0.508051040926913	0.30570877440606	no	1447	0.338425951345602	1118	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis	threonine catabolic process|glycine biosynthetic process	threonine aldolase activity|L-allo-threonine aldolase activity	cytosol
YPR164W	YPR164W	MMS1	hom	Verified	0.508033739720036	0.305714840920376	no	1448	0.309528732797312	1072	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay	replication fork processing|negative regulation of transposition, RNA-mediated|recombinational repair|nonfunctional rRNA decay	molecular_function	Cul8-RING ubiquitin ligase complex
YEL020C_p	YEL020C	YEL020C	hom	Uncharacterized	0.507699802778872	0.305831943384223	no	1449	0.311919521985019	1042	NA					Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cytoplasm
YKR090W	YKR090W	PXL1	hom	Verified	0.507157198673309	0.306022261998066	no	1450	0.309433627801641	1059	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress	maintenance of cell polarity|regulation of Rho protein signal transduction	Rho GDP-dissociation inhibitor activity	incipient cellular bud site|cellular bud|mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YPR015C_p	YPR015C	YPR015C	hom	Uncharacterized	0.506970520096027	0.306087751698623	no	1451	0.311623668727795	1037	NA					Putative protein of unknown function; overexpression causes a cell cycle delay or arrest	biological_process	sequence-specific DNA binding	cellular_component
YBR068C	YBR068C	BAP2	hom	Verified	0.506692349508895	0.306185349694682	no	1452	0.298211950419052	1002	NA	FT		PLASMA MEMBRANE		High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YAL021C	YAL021C	CCR4	hom	Verified	0.506106743618847	0.306390858365442	no	1453	0.350751804013044	1162	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING	NUCLEUS	RNA POL II, HOLOENZYME	Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening	regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|DNA replication checkpoint|nuclear-transcribed mRNA poly(A) tail shortening|traversing start control point of mitotic cell cycle|replication fork protection|transcription elongation from RNA polymerase II promoter|DNA replication	3'-5'-exoribonuclease activity	CCR4-NOT core complex|cytoplasmic mRNA processing body|Cdc73/Paf1 complex|cytoplasm
YHR143W	YHR143W	DSE2	hom	Verified	0.50591368123483	0.306458623760551	no	1454	0.372908049695091	1245	NA	FF|FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION			Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP	cytokinesis, completion of separation|pseudohyphal growth	glucosidase activity	extracellular region|fungal-type cell wall
YHR195W	YHR195W	NVJ1	hom	Verified	0.505656830575095	0.306548789265704	no	1455	0.324267022682604	1117	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)	microautophagy|cellular protein localization	protein binding	nuclear envelope
YGR282C	YGR282C	BGL2	hom	Verified	0.504990470371578	0.306782764629668	no	1456	0.308496783669212	1072	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance	fungal-type cell wall organization	1,3-beta-glucanosyltransferase activity|glucan endo-1,3-beta-D-glucosidase activity	fungal-type cell wall
YHR163W	YHR163W	SOL3	hom	Verified	0.503209739140848	0.307408409101347	no	1457	0.304489008507931	1028	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	6-phosphogluconolactonase activity	nucleus|cytoplasm
YNL004W	YNL004W	HRB1	hom	Verified	0.502153380025534	0.307779816858389	no	1458	0.321217676984333	1068	NA	FT	RNA LOCALIZATION	NUCLEUS		Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication	poly(A)+ mRNA export from nucleus	RNA binding	integral to membrane|nucleus|cytoplasm
YDR048C_d	YDR048C	YDR048C	hom	Dubious	0.500576641145452	0.308334552647875	no	1459	0.311397910279975	1078	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR034W	YGR034W	RPL26B	hom	Verified	0.499867250196135	0.308584276880028	no	1460	0.322804054482302	1083	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YJL218W_p	YJL218W	YJL218W	hom	Uncharacterized	0.498207754873069	0.309168808559689	no	1461	0.311375066199692	1074	NA					Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene	biological_process	acetyltransferase activity	cellular_component
YLL019C	YLL019C	KNS1	hom	Verified	0.49790325972158	0.309276114819136	no	1462	0.278391536030686	944	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation	negative regulation of transcription from RNA polymerase III promoter|protein autophosphorylation|protein phosphorylation	protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity	nucleus|cytoplasm
YOR305W	YOR305W	RRG7	hom	Verified	0.49677764322732	0.309672931266343	no	1463	0.289181610524256	990	NA	FT		MITOCHONDRION		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene	biological_process	molecular_function	mitochondrion
YJL108C	YJL108C	PRM10	hom	Verified	0.493426092814417	0.310855774703373	no	1464	0.325587820979998	1100	NA					Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	integral to membrane
YER119C	YER119C	AVT6	hom	Verified	0.492192020786989	0.311291802330951	no	1465	0.302935100312013	1040	NA	FT	VACUOLAR TRANSPORT			Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication	amino acid export from vacuole|transmembrane transport	L-aspartate transmembrane transporter activity|transporter activity|L-glutamate transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YFL010W-A	YFL010W-A	AUA1	hom	Verified	0.492011588623965	0.311355575608262	no	1466	0.323388355963959	1086	NA					Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease	amino acid transport	molecular_function	cellular_component
YPL078C	YPL078C	ATP4	hom	Verified	0.490700478214674	0.311819154108401	no	1467	0.308358613920781	1063	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated	protein complex oligomerization|ATP synthesis coupled proton transport	proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase, stator stalk|integral to membrane
YER091C-A_d	YER091C-A	YER091C-A	hom	Dubious	0.490212934994193	0.311991614313133	no	1468	0.325369864780112	1100	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL014C-A_p	YIL014C-A	YIL014C-A	hom	Uncharacterized	0.489791308840227	0.312140790706187	no	1469	0.31992452630139	1083	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YFL041W-A_p	YFL041W-A	YFL041W-A	hom	Uncharacterized	0.489473264155399	0.312253339119185	no	1470	0.309417896132336	1054	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YDR132C	YDR132C	YDR132C	hom	Verified	0.488776198501835	0.312500075270114	no	1471	0.311908328121941	1037	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YHR156C	YHR156C	LIN1	hom	Verified	0.488641752970232	0.312547673824097	no	1472	0.315759080552352	1087	NA	FT		NUCLEUS|CHROMOSOME		Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication	biological_process	protein binding	chromatin|nucleus|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YDR077W	YDR077W	SED1	hom	Verified	0.48842400285739	0.312624771829721	no	1473	0.307201350746478	1030	NA	FT	CELL WALL ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites	fungal-type cell wall organization|mitochondrial genome maintenance	structural constituent of cell wall	mitochondrion|ribosome|fungal-type cell wall
YNL220W	YNL220W	ADE12	hom	Verified	0.488287504991979	0.312673105323412	no	1474	0.303813878216855	1027	NA	FT	NUCLEOTIDE METABOLISM			Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence	purine nucleotide biosynthetic process	DNA replication origin binding|adenylosuccinate synthase activity	cytoplasm
YOR030W	YOR030W	DFG16	hom	Verified	0.487934688824268	0.31279805141679	no	1475	0.341779617854215	1182	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p	pseudohyphal growth|protein processing	molecular_function	integral to membrane
YDR519W	YDR519W	FPR2	hom	Verified	0.487277046237551	0.313031005953824	no	1476	0.335299271241239	1133	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress	biological_process	FK506 binding|peptidyl-prolyl cis-trans isomerase activity	endoplasmic reticulum membrane
YMR176W	YMR176W	ECM5	hom	Verified	0.48630655751466	0.313374915298701	no	1477	0.305363694164203	1035	NA	FT	CELL WALL ORG/BIOGENESIS	NUCLEUS|CHROMOSOME		Non-essential protein of unknown function; contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress	fungal-type cell wall organization	molecular_function	nucleus|Snt2C complex
YCR050C_p	YCR050C	YCR050C	hom	Uncharacterized	0.484642485577759	0.313964985476254	no	1478	0.274405033325892	942	NA					Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein	biological_process	molecular_function	cellular_component
YOR380W	YOR380W	RDR1	hom	Verified	0.484386737938789	0.314055714330343	no	1479	0.305028348695149	996	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins	response to xenobiotic stimulus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YEL027W	YEL027W	VMA3	hom	Verified	0.482456234018784	0.314740940889939	no	1480	0.329565846285775	1086	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis	cellular copper ion homeostasis|cellular iron ion homeostasis|endocytosis|vacuole organization|proton transport|vacuolar acidification|protein targeting to vacuole	hydrogen ion transmembrane transporter activity	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YPR195C_d	YPR195C	YPR195C	hom	Dubious	0.479971745249537	0.315623742067216	no	1481	0.299924453503887	1015	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR012C_d	YBR012C	YBR012C	hom	Dubious	0.479555216632723	0.315771848348006	no	1482	0.313895481848133	1047	NA					Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p	Unknown	Unknown	Unknown
YDR200C	YDR200C	VPS64	hom	Verified	0.479368824417717	0.315838133948568	no	1483	0.366187210679862	1236	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance	re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole	molecular_function	endoplasmic reticulum membrane|cytoplasm
YPR154W	YPR154W	PIN3	hom	Verified	0.478627247324776	0.316101915423796	no	1484	0.319419837904922	1079	NA	FT	CYTOSKELETON ORGANIZATION	NUCLEUS		Protein that induces appearance of [PIN+] prion when overproduced	actin cytoskeleton organization	molecular_function	nucleus|cytoplasm
YPR047W	YPR047W	MSF1	hom	Verified	0.478057425735796	0.316304666514179	no	1485	0.347517995810426	1187	NA	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase	phenylalanyl-tRNA aminoacylation|mitochondrial phenylalanyl-tRNA aminoacylation	phenylalanine-tRNA ligase activity	mitochondrion
YNR007C	YNR007C	ATG3	hom	Verified	0.477835816547945	0.316383533317399	no	1486	0.32471351984543	1099	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly	Atg8 ligase activity	cytosol|cytoplasm
YGR169C-A_p	YGR169C-A	YGR169C-A	hom	Uncharacterized	0.477312695837843	0.316569735877434	no	1487	0.316169391891756	1066	NA					Putative protein of unknown function; YGR169C-A has a paralog, YJR005C-A, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YGR223C	YGR223C	HSV2	hom	Verified	0.475609266584805	0.317176386197391	no	1488	0.321611041591594	1076	NA	FT	MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS			Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization	piecemeal microautophagy of nucleus	phosphatidylinositol binding	endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YOR090C	YOR090C	PTC5	hom	Verified	0.475603693080003	0.317178371923786	no	1489	0.324012781700711	1072	NA	FT		MITOCHONDRION		Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p	positive regulation of catalytic activity|regulation of catalytic activity|protein dephosphorylation	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|protein serine/threonine phosphatase activity	mitochondrion
YKR043C	YKR043C	SHB17	hom	Verified	0.47521744921956	0.317315995574263	no	1490	0.356072944874921	1181	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus	ribose phosphate biosynthetic process	sedoheptulose-bisphosphatase activity	nucleus|cytoplasm
YKL194C	YKL194C	MST1	hom	Verified	0.47379694512768	0.317822356619734	no	1491	0.346201665703353	1153	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro	mitochondrial threonyl-tRNA aminoacylation	threonine-tRNA ligase activity	mitochondrion
YKR049C	YKR049C	FMP46	hom	Verified	0.473305934259184	0.317997464499354	no	1492	0.299641278451853	1014	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	oxidoreductase activity	mitochondrion
YGR108W	YGR108W	CLB1	hom	Verified	0.472328170524569	0.31834628292416	no	1493	0.29870675432669	1029	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|meiotic G2/MI transition|regulation of cyclin-dependent protein kinase activity|mitotic spindle organization in nucleus|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YLR185W	YLR185W	RPL37A	hom	Verified	0.472065167122458	0.318440137224688	no	1494	0.308164142134418	1021	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YEL017W	YEL017W	GTT3	hom	Verified	0.469473790803674	0.319365507271952	no	1495	0.305499005711518	1036	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery	biological_process	molecular_function	cellular_component
YBL012C_d	YBL012C	YBL012C	hom	Dubious	0.468965263711206	0.319547232619756	no	1496	0.319100353967052	1091	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR033C_d	YKR033C	YKR033C	hom	Dubious	0.467846577362479	0.319947154706851	no	1497	0.319446895517631	1059	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80	Unknown	Unknown	Unknown
YGL136C	YGL136C	MRM2	hom	Verified	0.466304869576005	0.32049864683048	no	1498	0.299456212492148	1009	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	MITOCHONDRION		Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ	rRNA methylation	rRNA (uridine-2'-O-)-methyltransferase activity	mitochondrion
YER038W-A_d	YER038W-A	YER038W-A	hom	Dubious	0.466135404703077	0.320559291183519	no	1499	0.328684120856236	1096	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria	Unknown	Unknown	Unknown
YIL053W	YIL053W	RHR2	hom	Verified	0.465642046483767	0.320735870617834	no	1500	0.335121792922042	1133	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication	glycerol biosynthetic process|response to osmotic stress	glycerol-1-phosphatase activity	nucleus|cytoplasm
YML099C	YML099C	ARG81	hom	Verified	0.465197000387701	0.320895193310219	no	1501	0.315160517435573	1100	NA	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p	arginine metabolic process|negative regulation of calcium ion-dependent exocytosis	transcription cofactor activity	nucleus
YOR156C	YOR156C	NFI1	hom	Verified	0.464835843145845	0.321024508759519	no	1502	0.318638665479285	1087	NA	FT	CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	RSC COMPLEX	SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length	protein sumoylation|chromosome segregation|chromosome condensation	SUMO ligase activity	nuclear chromatin|nucleus|cytoplasm
YMR116C	YMR116C	ASC1	hom	Verified	0.464602260139761	0.321108156721786	no	1503	0.321763441318681	1089	NA	FT	SIGNALING|TRANSLATION		RIBOSOME	G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation	negative regulation of translation|glucose mediated signaling pathway|G-protein coupled receptor signaling pathway|invasive growth in response to glucose limitation	G-protein alpha-subunit binding|GDP-dissociation inhibitor activity|signal transducer activity	cytosolic small ribosomal subunit|cytoplasm
YER132C	YER132C	PMD1	hom	Verified	0.464135955832757	0.321275171210227	no	1504	0.324799989397234	1118	NA	FT	CELL CYCLE			Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions	sporulation resulting in formation of a cellular spore	molecular_function	cytoplasm
YGR236C	YGR236C	SPG1	hom	Verified	0.463641666323579	0.32145224852446	no	1505	0.320193302273696	1102	NA	FT		MITOCHONDRION		Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPL248C	YPL248C	GAL4	hom	Verified	0.463375028137456	0.321547787482487	no	1506	0.309312274598208	1030	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p	galactose metabolic process|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YHR182W	YHR182W	YHR182W	hom	Verified	0.46286364845921	0.321731052634459	no	1507	0.341699385600585	1156	NA	FT	SIGNALING			Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cytoplasm
YDR018C_p	YDR018C	YDR018C	hom	Uncharacterized	0.462408635067042	0.321894154053828	no	1508	0.316587944215322	1098	NA	FT	LIPID METABOLISM			Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication	phospholipid biosynthetic process	transferase activity, transferring acyl groups	integral to membrane
YIL015W	YIL015W	BAR1	hom	Verified	0.462199567647393	0.32196910663828	no	1509	0.321685886206787	1066	NA	FT	SIGNALING|PROTEOLYSIS			Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|peptide catabolic process	aspartic-type endopeptidase activity	cell wall-bounded periplasmic space
YKR014C	YKR014C	YPT52	hom	Verified	0.462197059942508	0.321970005717411	no	1510	0.325727909952361	1120	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress	endocytosis|protein targeting to vacuole	GTPase activity	late endosome
YIR018W	YIR018W	YAP5	hom	Verified	0.462137501579381	0.321991359286447	no	1511	0.312306310838666	1077	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS|CHROMOSOME		Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication	negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to iron|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nuclear chromatin|nucleus
YPL149W	YPL149W	ATG5	hom	Verified	0.461541528047421	0.322205067125261	no	1512	0.306840288866765	1048	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation	C-terminal protein lipidation|mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy|CVT pathway	Atg8 ligase activity	cytosol|Atg12-Atg5-Atg16 complex|pre-autophagosomal structure|autophagic vacuole
YFL050C	YFL050C	ALR2	hom	Verified	0.461237789848339	0.322314006049621	no	1513	0.333984286488001	1123	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition	magnesium ion transport|cation transport|transmembrane transport	inorganic cation transmembrane transporter activity	integral to membrane|plasma membrane
YLR188W	YLR188W	MDL1	hom	Verified	0.460537735785202	0.322565145973855	no	1514	0.331516395329761	1106	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress	oligopeptide transport|oligopeptide export from mitochondrion	ATPase activity|oligopeptide-transporting ATPase activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YJL161W_p	YJL161W	FMP33	hom	Uncharacterized	0.460277505331064	0.322658522639034	no	1515	0.305463573114775	1039	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPL212C	YPL212C	PUS1	hom	Verified	0.457135278129607	0.323786907420653	no	1516	0.308960390618175	1045	NA	FT	RNA PROCESSING	NUCLEUS		tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA	snRNA pseudouridine synthesis|tRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus
YBR047W_p	YBR047W	FMP23	hom	Uncharacterized	0.456826119585381	0.323898015122467	no	1517	0.319477145329547	1101	NA	FT		MITOCHONDRION		Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YCL046W_d	YCL046W	YCL046W	hom	Dubious	0.456717713627748	0.323936978580045	no	1518	0.348887300592139	1196	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C	Unknown	Unknown	Unknown
YLR294C_d	YLR294C	YLR294C	hom	Dubious	0.456439816006091	0.324036869836461	no	1519	0.329828565131982	1111	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14	Unknown	Unknown	Unknown
YPL197C_d	YPL197C	YPL197C	hom	Dubious	0.45602312167095	0.324186675792202	no	1520	0.33394437435416	1102	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B	Unknown	Unknown	Unknown
YBR242W_p	YBR242W	YBR242W	hom	Uncharacterized	0.453894127730351	0.324952515171917	no	1521	0.362587402391709	1195	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YPL103C	YPL103C	FMP30	hom	Verified	0.453862147574289	0.324964024690228	no	1522	0.33404594315532	1109	NA	FT	LIPID METABOLISM	MITOCHONDRION		Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D	N-acylphosphatidylethanolamine metabolic process|N-acylethanolamine metabolic process	NAPE-specific phospholipase D activity	mitochondrion|integral to mitochondrial inner membrane
YMR190C	YMR190C	SGS1	hom	Verified	0.453662684908269	0.325035814201395	no	1523	0.303693050036174	1020	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes; forms nuclear foci upon DNA replication stress	DNA double-strand break processing|meiotic DNA double-strand break processing|telomeric 3' overhang formation|meiotic chromosome segregation|DNA unwinding involved in replication|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint|telomere maintenance via recombination|replicative cell aging|DNA duplex unwinding|response to DNA damage stimulus|negative regulation of meiotic joint molecule formation|chromosome organization|regulation of reciprocal meiotic recombination|gene conversion at mating-type locus, DNA double-strand break processing|mitotic sister chromatid segregation	ATP-dependent DNA helicase activity	RecQ helicase-Topo III complex|nucleolus
YPR100W	YPR100W	MRPL51	hom	Verified	0.453121295763108	0.325230700759515	no	1524	0.350789775684569	1158	NA	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation|aerobic respiration	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YBR270C_p	YBR270C	BIT2	hom	Uncharacterized	0.452478321272071	0.32546221761285	no	1525	0.300665860686504	1028	NA					Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YHR133C	YHR133C	NSG1	hom	Verified	0.452393203303431	0.325492871226862	no	1526	0.316162646490599	1063	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; forms foci at the nuclear periphery upon DNA replication stress	sterol biosynthetic process	unfolded protein binding	integral to membrane|endoplasmic reticulum
YOR107W	YOR107W	RGS2	hom	Verified	0.452074283432651	0.325607734634937	no	1527	0.338750846785467	1181	NA	FT	SIGNALING	NUCLEUS|PLASMA MEMBRANE		Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	GTPase activator activity	nucleus|cytoplasm
YNL227C	YNL227C	JJJ1	hom	Verified	0.452003259592698	0.325633317109658	no	1528	0.270635811321914	941	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION	RIBOSOME	Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis	ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|endocytosis|regulation of cell size|rRNA processing	ATPase activator activity	cytosol|mitochondrion|cytosolic large ribosomal subunit|nucleolus|cytoplasm
YGR148C	YGR148C	RPL24B	hom	Verified	0.45198015567545	0.325641639216058	no	1529	0.324829254522373	1068	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YOR073W	YOR073W	SGO1	hom	Verified	0.451563670886513	0.325791673296316	no	1530	0.334721257594631	1132	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability	positive regulation of maintenance of meiotic sister chromatid cohesion|meiotic sister chromatid segregation|meiotic sister chromatid separation|sister chromatid biorientation|maintenance of meiotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint|mitotic sister chromatid segregation	molecular_function	condensed nuclear chromosome kinetochore|nucleus|spindle pole body|condensed nuclear chromosome, centromeric region
YNL193W_p	YNL193W	YNL193W	hom	Uncharacterized	0.449643362699633	0.326483807965832	no	1531	0.301967584127881	1035	NA					Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis	biological_process	molecular_function	cellular_component
YGL168W	YGL168W	HUR1	hom	Verified	0.449460497717136	0.326549749010266	no	1532	0.396325013349094	1315	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene	DNA replication	molecular_function	cellular_component
YDR125C	YDR125C	ECM18	hom	Verified	0.449017864336781	0.326709384876086	no	1533	0.341850832166054	1134	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	mitochondrion
YHR194W	YHR194W	MDM31	hom	Verified	0.448823717744548	0.326779413917336	no	1534	0.356337565122799	1181	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	NUCLEUS|MITOCHONDRION		Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34	mitochondrion inheritance|cellular ion homeostasis|mitochondrion organization|Unknown	molecular_function	mitochondrial inner membrane|nucleus
YJL046W	YJL046W	AIM22	hom	Verified	0.448253201902388	0.326985235361869	no	1535	0.326178216902569	1105	NA	FT		MITOCHONDRION		Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss	protein lipoylation	lipoate-protein ligase activity	mitochondrion
YOR161C	YOR161C	PNS1	hom	Verified	0.448136524606157	0.327027334788477	no	1536	0.329572060155915	1145	NA	FT		PLASMA MEMBRANE		Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport	biological_process	choline transmembrane transporter activity|molecular_function	integral to membrane|plasma membrane|integral to plasma membrane
YLR406C	YLR406C	RPL31B	hom	Verified	0.448020892487789	0.327069059266521	no	1537	0.352397136748046	1171	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication	cytoplasmic translation|regulation of translational fidelity	structural constituent of ribosome	cytosolic large ribosomal subunit
YKL212W	YKL212W	SAC1	hom	Verified	0.448010215502863	0.327072912038877	no	1538	0.403846745214723	1340	NA	FF|FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|mitochondrion|SPOTS complex|integral to Golgi membrane
YGR038W	YGR038W	ORM1	hom	Verified	0.447242273683381	0.327350070885162	no	1539	0.351637763578988	1189	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control	cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein	molecular_function	integral to membrane|endoplasmic reticulum|SPOTS complex
YLR444C_d	YLR444C	YLR444C	hom	Dubious	0.447062850917449	0.327414840306608	no	1540	0.318930318297312	1082	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR013W	YLR013W	GAT3	hom	Verified	0.44685751117429	0.327488971814877	no	1541	0.323766264993441	1066	NA	FT		NUCLEUS		Protein containing GATA family zinc finger motifs	transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YGR166W	YGR166W	TRS65	hom	Verified	0.446049094565942	0.327780891495831	no	1542	0.362384047243301	1190	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS	GOLGI APPARATUS		Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response	intra-Golgi vesicle-mediated transport|protein complex assembly	Rab guanyl-nucleotide exchange factor activity	TRAPP complex|trans-Golgi network
YIL039W	YIL039W	TED1	hom	Verified	0.446023585347799	0.327790104602804	no	1543	0.354280847629954	1149	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	ER to Golgi vesicle-mediated transport	molecular_function	endoplasmic reticulum
YDR175C	YDR175C	RSM24	hom	Verified	0.445035567259644	0.328147025484722	no	1544	0.333663905230463	1127	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YPL084W	YPL084W	BRO1	hom	Verified	0.444896502302586	0.328197275217096	no	1545	0.335596761916743	1127	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes	protein deubiquitination|vacuolar transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|response to nutrient|ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	endosome|cytoplasm
YBL089W	YBL089W	AVT5	hom	Verified	0.44473867047373	0.328254309937668	no	1546	0.356372934092394	1163	NA					Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication	transport	transporter activity	integral to membrane
YOR084W	YOR084W	LPX1	hom	Verified	0.442963913754028	0.328895918248556	no	1547	0.300309202043609	990	NA	FT	PEROXISOME ORGANIZATION			Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction	peroxisome organization	lipase activity	peroxisomal matrix
YBR150C	YBR150C	TBS1	hom	Verified	0.442438485273954	0.329085967520348	no	1548	0.313090285806563	1060	NA	FT	TRANSCRIPTION FROM RNA POL II	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication	biological_process	sequence-specific DNA binding	mitochondrion|nucleus|cytoplasm
YIR025W	YIR025W	MND2	hom	Verified	0.442228003097048	0.329162112038947	no	1549	0.338013042341886	1117	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CHROMOSOME SEGREGATION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|reciprocal meiotic recombination|regulation of mitotic metaphase/anaphase transition|protein ubiquitination|mitotic sister chromatid segregation	molecular_function	nucleus|anaphase-promoting complex
YML119W_p	YML119W	YML119W	hom	Uncharacterized	0.442009594461109	0.329241131544997	no	1550	0.329687002100944	1094	NA					Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate	biological_process	molecular_function	cellular_component
YGL067W	YGL067W	NPY1	hom	Verified	0.441605303409383	0.329387422809094	no	1551	0.284956207684372	959	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member	NADH metabolic process	NAD+ diphosphatase activity	peroxisome|cytoplasm
YOL079W_d	YOL079W	YOL079W	hom	Dubious	0.44138509744557	0.329467114535142	no	1552	0.349672999633188	1157	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR180C	YOR180C	DCI1	hom	Verified	0.440948928574599	0.329624985304174	no	1553	0.359812684900009	1200	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed	fatty acid beta-oxidation	dodecenoyl-CoA delta-isomerase activity	peroxisomal matrix
YNL146W_p	YNL146W	YNL146W	hom	Uncharacterized	0.440140605561953	0.329917637057148	no	1554	0.33767649747185	1133	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YML054C	YML054C	CYB2	hom	Verified	0.438179006328429	0.330628262881691	no	1555	0.285282347519827	966	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions	lactate metabolic process	L-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial intermembrane space
YER044C	YER044C	ERG28	hom	Verified	0.437413136824589	0.330905879347459	no	1556	0.339464425324162	1158	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p	ergosterol biosynthetic process	protein binding, bridging	endoplasmic reticulum membrane
YNL202W	YNL202W	SPS19	hom	Verified	0.437295394978658	0.330948567292844	no	1557	0.349634045707268	1197	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate	fatty acid catabolic process|ascospore formation	2,4-dienoyl-CoA reductase (NADPH) activity	peroxisomal matrix
YGL161C	YGL161C	YIP5	hom	Verified	0.43615102657636	0.331363578693495	no	1558	0.33347801203519	1109	NA	FT		GOLGI APPARATUS		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YDR120C	YDR120C	TRM1	hom	Verified	0.435114018036078	0.331739834416656	no	1559	0.33836092072467	1144	NA	FT	RNA PROCESSING	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments	tRNA methylation	tRNA (guanine-N2-)-methyltransferase activity	mitochondrion|nuclear envelope|nuclear inner membrane
YNL121C	YNL121C	TOM70	hom	Verified	0.435064611689996	0.331757764662339	no	1560	0.362889710853785	1213	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication	protein import into mitochondrial matrix|protein import into mitochondrial inner membrane	mitochondrion targeting sequence binding|protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YBR053C_p	YBR053C	YBR053C	hom	Uncharacterized	0.434093130978543	0.332110406688224	no	1561	0.314871148047021	1073	NA					Putative protein of unknown function; induced by cell wall perturbation	biological_process	molecular_function	cellular_component
YMR299C	YMR299C	DYN3	hom	Verified	0.433909320737277	0.332177145512829	no	1562	0.331239994718243	1128	NA	FT		CYTOSKELETON		Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration	nuclear migration along microtubule	motor activity	cytoplasmic dynein complex|cytoplasmic microtubule
YBR200W-A_p	YBR200W-A	YBR200W-A	hom	Uncharacterized	0.432202837233663	0.332796998719111	no	1563	0.346389265020907	1183	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YPR148C	YPR148C	YPR148C	hom	Verified	0.432126221288451	0.332824838990778	no	1564	0.317290168628065	1082	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	ribosome|cytoplasm
YER153C	YER153C	PET122	hom	Verified	0.431645207244053	0.332999648225469	no	1565	0.332944110297374	1103	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	translation initiation factor activity	mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YFR024C-A	YFR024C-A	LSB3	hom	Verified	0.431067526741732	0.333209635776782	no	1566	0.314743034120306	1076	NA	FT		MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication	actin cortical patch localization	molecular_function	mitochondrion|cellular bud neck|cytoplasm
YMR193W	YMR193W	MRPL24	hom	Verified	0.430955241910112	0.33325045751921	no	1567	0.309919286293126	1049	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YAL036C	YAL036C	RBG1	hom	Verified	0.430756759204525	0.333322621784996	no	1568	0.334959607273112	1126	NA	FT	TRANSLATION		RIBOSOME	Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid	cytoplasmic translation	GTP binding	polysomal ribosome|polysome|cytoplasm
YBR105C	YBR105C	VID24	hom	Verified	0.429704197862671	0.333705414696821	no	1569	0.342660633185506	1161	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles	negative regulation of gluconeogenesis|vesicle fusion with vacuole|vacuolar protein catabolic process|proteasomal ubiquitin-dependent protein catabolic process|vesicle-mediated transport|protein targeting to vacuole	molecular_function	cytoplasmic membrane-bounded vesicle|GID complex|extrinsic to membrane
YNR001C	YNR001C	CIT1	hom	Verified	0.429611996244371	0.333738954608021	no	1570	0.344493788950139	1168	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication	glutamate biosynthetic process|tricarboxylic acid cycle|acetyl-CoA catabolic process|citrate metabolic process	citrate (Si)-synthase activity	mitochondrion
YIR014W_p	YIR014W	YIR014W	hom	Uncharacterized	0.429143805979842	0.333909287298904	no	1571	0.318397248788775	1076	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene	biological_process	molecular_function	fungal-type vacuole
YEL067C_p	YEL067C	YEL067C	hom	Uncharacterized	0.428857157659144	0.334013589958197	no	1572	0.341073446225434	1127	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPL172C	YPL172C	COX10	hom	Verified	0.428433129099211	0.334167904645654	no	1573	0.358867976130879	1207	NA	FT	COFACTOR METABOLISM	MITOCHONDRION		Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders	heme a biosynthetic process	protoheme IX farnesyltransferase activity	mitochondrion|integral to membrane
YOR034C-A_p	YOR034C-A	YOR034C-A	hom	Uncharacterized	0.42817679503454	0.334261204675543	no	1574	0.350270606504448	1173	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YIL110W	YIL110W	HPM1	hom	Verified	0.427404339696827	0.334542423542903	no	1575	0.326476421899867	1086	NA	FT		NUCLEUS		AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance	peptidyl-histidine methylation, to form tele-methylhistidine	S-adenosylmethionine-dependent methyltransferase activity|protein-histidine N-methyltransferase activity	nucleus|cytoplasm
YFL056C	YFL056C	AAD6	hom	Verified	0.42717785151232	0.334624896084011	no	1576	0.328558886873237	1109	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YOR106W	YOR106W	VAM3	hom	Verified	0.426649050714389	0.334817482642544	no	1577	0.360967950424736	1219	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS			Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region	autophagic vacuole fusion|vesicle fusion with vacuole|piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle docking|vesicle fusion	protein homodimerization activity|SNAP receptor activity	SNARE complex|fungal-type vacuole membrane
YNL224C	YNL224C	SQS1	hom	Verified	0.426501109406661	0.334871369894782	no	1578	0.328340867556044	1125	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM	NUCLEUS		Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress	positive regulation of helicase activity|positive regulation of ATPase activity|mRNA splicing, via spliceosome|maturation of SSU-rRNA|rRNA processing	molecular_function	preribosome, small subunit precursor|nucleus|preribosome, large subunit precursor|90S preribosome|cytoplasm
YDL075W	YDL075W	RPL31A	hom	Verified	0.425031652023314	0.335406800542612	no	1579	0.357422211442241	1188	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication	cytoplasmic translation|regulation of translational fidelity	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR114W	YBR114W	RAD16	hom	Verified	0.424190093223165	0.335713592585283	no	1580	0.344713098215609	1179	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|damaged DNA binding|DNA-dependent ATPase activity	nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YHR018C	YHR018C	ARG4	hom	Verified	0.424153762772206	0.335726839395876	no	1581	0.331734461059271	1120	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway	arginine biosynthetic process via ornithine	argininosuccinate lyase activity	cytosol
YKL071W_p	YKL071W	YKL071W	hom	Uncharacterized	0.423867459542711	0.33583123843347	no	1582	0.339730306987897	1133	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	integral to membrane|cytoplasm
YMR246W	YMR246W	FAA4	hom	Verified	0.42348201247669	0.335971809783856	no	1583	0.331062263297625	1140	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM			Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication	long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process	long-chain fatty acid-CoA ligase activity	lipid particle|cytoplasm
YDL076C	YDL076C	RXT3	hom	Verified	0.423146366386873	0.336094237564722	no	1584	0.34409427360011	1146	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase I promoter	molecular_function	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YFL016C	YFL016C	MDJ1	hom	Verified	0.422765318716975	0.33623324676564	no	1585	0.402789193526493	1315	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones	protein refolding|response to heat|misfolded or incompletely synthesized protein catabolic process|mitochondrial genome maintenance|'de novo' protein folding	unfolded protein binding|ATPase activator activity	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YJL038C	YJL038C	LOH1	hom	Verified	0.42243375038909	0.336354223734251	no	1586	0.342253988355098	1157	NA					Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1	chromosome organization	molecular_function	cellular_component
YPL148C	YPL148C	PPT2	hom	Verified	0.422271423489753	0.33641345697072	no	1587	0.371384805556526	1250	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation	protein-cofactor linkage	holo-[acyl-carrier-protein] synthase activity	mitochondrion
YCL037C	YCL037C	SRO9	hom	Verified	0.422180274661548	0.336446719043026	no	1588	0.358664292505501	1223	NA	FT	TRANSLATION			Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication	cytoplasmic translation	RNA binding	polysome
YGR111W_p	YGR111W	YGR111W	hom	Uncharacterized	0.422128550387828	0.336465594858065	no	1589	0.364907956801233	1213	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	regulation of cell size	molecular_function	nucleus|cytoplasm
YHL023C	YHL023C	NPR3	hom	Verified	0.422081117465004	0.336482904986402	no	1590	0.354651296904246	1191	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO NUTRIENT LEVELS			Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair	meiosis|regulation of TOR signaling cascade|cellular response to amino acid starvation	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YDL039C	YDL039C	PRM7	hom	Verified	0.421711893954813	0.336617660929131	no	1591	0.33398572759695	1093	NA					Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements	conjugation with cellular fusion	molecular_function	integral to membrane
YPL104W	YPL104W	MSD1	hom	Verified	0.421672384717881	0.336632081905336	no	1592	0.356912572855006	1220	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene	mitochondrial aspartyl-tRNA aminoacylation	aspartate-tRNA ligase activity	mitochondrion
YDR516C	YDR516C	EMI2	hom	Verified	0.42153955851334	0.336680565583542	no	1593	0.322800955147382	1043	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YHL020C	YHL020C	OPI1	hom	Verified	0.420044369839612	0.337226520353062	no	1594	0.350838901285757	1193	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|SIGNALING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance	endoplasmic reticulum unfolded protein response|negative regulation of transcription from RNA polymerase II promoter|phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	transcription corepressor activity	nuclear membrane|nucleoplasm|nuclear envelope|endoplasmic reticulum|nucleus
YML061C	YML061C	PIF1	hom	Verified	0.419715382266433	0.337346693294806	no	1595	0.357020025717803	1187	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION		DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells	chromosome organization|negative regulation of telomere maintenance via telomerase|telomere maintenance|mitochondrial genome maintenance|DNA recombination	DNA helicase activity|telomerase inhibitor activity	mitochondrion|nucleus|mitochondrial membrane
YNL237W	YNL237W	YTP1	hom	Verified	0.419572942850153	0.337398728869579	no	1596	0.386664114338471	1290	NA	FF|FT		MITOCHONDRION		Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins	biological_process	molecular_function	integral to membrane|membrane
YNL148C	YNL148C	ALF1	hom	Verified	0.41947970827057	0.337432790753176	no	1597	0.367797390957064	1212	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS|CYTOSKELETON		Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance	protein folding|post-chaperonin tubulin folding pathway	microtubule binding|alpha-tubulin binding	nucleus|cytoplasm
YMR216C	YMR216C	SKY1	hom	Verified	0.418838477654511	0.337667091011424	no	1598	0.394468451352283	1285	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS			SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1	cellular cation homeostasis|cellular ion homeostasis|response to drug|protein phosphorylation|positive regulation of protein import into nucleus|regulation of cell size|mRNA splice site selection	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YDL021W	YDL021W	GPM2	hom	Verified	0.417824355526831	0.338037771124878	no	1599	0.34545722871554	1151	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event	biological_process	phosphoglycerate mutase activity|molecular_function	cytosol|cytoplasm
YGR165W	YGR165W	MRPS35	hom	Verified	0.417563071537238	0.338133300648139	no	1600	0.366371637091178	1200	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YDR174W	YDR174W	HMO1	hom	Verified	0.417364356597747	0.338205960923903	no	1601	0.332910473149599	1142	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase	regulation of transcription from RNA polymerase I promoter|regulation of transcription by chromatin organization|regulation of ribosomal protein gene transcription from RNA polymerase II promoter	double-stranded DNA binding|four-way junction DNA binding|DNA binding, bending	nuclear chromatin|nucleolus|cytoplasm
YML020W_p	YML020W	YML020W	hom	Uncharacterized	0.417089761327852	0.33830637682002	no	1602	0.336613201984649	1140	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGR106C	YGR106C	VOA1	hom	Verified	0.416958527665267	0.338354371314972	no	1603	0.390237015788922	1273	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval	protein complex assembly	molecular_function	fungal-type vacuole membrane|endoplasmic reticulum membrane
YHR057C	YHR057C	CPR2	hom	Verified	0.416539351787136	0.338507689010525	no	1604	0.323918131388908	1090	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	cellular_component
YHR059W	YHR059W	FYV4	hom	Verified	0.415922478602396	0.338733365121443	no	1605	0.323406930133162	1104	NA	FT		MITOCHONDRION		Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	mitochondrion
YPR171W	YPR171W	BSP1	hom	Verified	0.415674791473494	0.33882399496745	no	1606	0.342227089938967	1150	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton	actin cortical patch localization	protein binding, bridging	mating projection tip|membrane|cellular bud neck|actin cortical patch|cellular bud tip
YKL222C	YKL222C	YKL222C	hom	Verified	0.415669212811777	0.338826036332594	no	1607	0.338159638353892	1106	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CYTOSKELETON		Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine	biological_process	sequence-specific DNA binding	ribosome|nucleus|mitotic spindle
YDR406W	YDR406W	PDR15	hom	Verified	0.414307891268735	0.339324317685643	no	1608	0.3411508860517	1116	NA	FT	NUCLEOTIDE METABOLISM			Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element	transport|response to drug	ATPase activity, coupled to transmembrane movement of substances	integral to membrane
YAL031C	YAL031C	GIP4	hom	Verified	0.414277614899769	0.339335402872838	no	1609	0.330350193985635	1091	NA	FT	CHROMOSOME SEGREGATION			Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate	chromosome segregation|regulation of phosphoprotein phosphatase activity	protein phosphatase 1 binding|protein phosphatase type 1 regulator activity	cytoplasm
YHR210C_p	YHR210C	YHR210C	hom	Uncharacterized	0.413914311571461	0.339468431165099	no	1610	0.341461344439192	1147	NA	FT	CARBOHYDRATE METABOLISM			Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions	biological_process	molecular_function	cellular_component
YBR040W	YBR040W	FIG1	hom	Verified	0.413304389055512	0.3396918072952	no	1611	0.331171872976142	1124	NA	FT		SITE OF POLARIZED GROWTH		Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating	cell morphogenesis involved in conjugation with cellular fusion|cytogamy	molecular_function	fungal-type cell wall|integral to membrane|mating projection tip
YOR239W	YOR239W	ABP140	hom	Verified	0.413275906543539	0.339702240018918	no	1612	0.336750593010262	1113	NA	FT	RNA PROCESSING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift	actin filament bundle assembly|tRNA methylation	tRNA (cytosine-3-)-methyltransferase activity|actin filament binding|protein binding, bridging	actin filament|actin filament bundle|mating projection tip|actin cortical patch
YKL053C-A	YKL053C-A	MDM35	hom	Verified	0.413217763425542	0.339723537366029	no	1613	0.352310865361207	1206	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION		Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	mitochondrion organization|mitochondrial respiratory chain complex assembly	molecular_function	nucleus|cytoplasm|mitochondrial intermembrane space
YHL004W	YHL004W	MRP4	hom	Verified	0.41289750127183	0.339840855935447	no	1614	0.345719887832123	1139	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome|tRNA binding	mitochondrion|mitochondrial small ribosomal subunit
YGR056W	YGR056W	RSC1	hom	Verified	0.412436042683446	0.340009924923398	no	1615	0.390893208969692	1306	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook	double-strand break repair|ATP-dependent chromatin remodeling|regulation of sporulation resulting in formation of a cellular spore|double-strand break repair via nonhomologous end joining|nucleosome disassembly|transcription elongation from RNA polymerase II promoter	DNA-dependent ATPase activity	RSC complex
YOL039W	YOL039W	RPP2A	hom	Verified	0.410597556320236	0.340683827931082	no	1616	0.352377512027825	1193	NA	FT	TRANSLATION		RIBOSOME	Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	translational elongation|cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YPR185W	YPR185W	ATG13	hom	Verified	0.409172689957142	0.341206467359741	no	1617	0.334646896988328	1106	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling	piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|activation of protein kinase activity|CVT pathway	protein kinase regulator activity	Atg1p signaling complex|extrinsic to membrane
YMR275C	YMR275C	BUL1	hom	Verified	0.409118837647527	0.34122622631128	no	1618	0.352421471675113	1206	NA	FT	MITOCHONDRION ORGANIZATION	PLASMA MEMBRANE	UBIQUITIN LIGASE COMPLEX	Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication	mitochondrion inheritance|protein monoubiquitination|protein polyubiquitination	ubiquitin-ubiquitin ligase activity	ubiquitin ligase complex|plasma membrane
YDR323C	YDR323C	PEP7	hom	Verified	0.409063038170618	0.341246700157222	no	1619	0.378405042706419	1240	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance	Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol-3-phosphate binding	external side of endosome membrane|cytoplasm
YDR185C	YDR185C	UPS3	hom	Verified	0.409029588984203	0.341258973497921	no	1620	0.343129563907948	1128	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations	mitochondrion morphogenesis	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YER137C_p	YER137C	YER137C	hom	Uncharacterized	0.407560668123903	0.341798122641801	no	1621	0.347570250816814	1142	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR224W_d	YBR224W	YBR224W	hom	Dubious	0.406197060924123	0.342298906715308	no	1622	0.332955702695509	1106	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1	Unknown	Unknown	Unknown
YBL008W-A_p	YBL008W-A	YBL008W-A	hom	Uncharacterized	0.405647533902607	0.342500798724782	no	1623	0.336365628382725	1122	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YKL215C	YKL215C	OXP1	hom	Verified	0.404714049788616	0.342843856764398	no	1624	0.304779425690257	1001	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	glutathione metabolic process	5-oxoprolinase (ATP-hydrolyzing) activity	cytoplasm
YPL150W_p	YPL150W	YPL150W	hom	Uncharacterized	0.404507715603454	0.34291970266017	no	1625	0.321509851928905	1063	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study	protein phosphorylation	protein kinase activity	cellular_component
YDR395W	YDR395W	SXM1	hom	Verified	0.403972512979097	0.343116466029161	no	1626	0.341478261728564	1145	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1	mRNA export from nucleus|nucleocytoplasmic transport	protein transporter activity	integral to membrane|nucleus|cytoplasm
YOR384W	YOR384W	FRE5	hom	Verified	0.403938806402558	0.34312885943256	no	1627	0.357379471393565	1156	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION|PLASMA MEMBRANE		Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	ferric-chelate reductase activity	mitochondrion|integral to membrane
YDL086W_p	YDL086W	YDL086W	hom	Uncharacterized	0.403741642552498	0.343201357007429	no	1628	0.311056108927772	1036	NA	FT		MITOCHONDRION		Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene	biological_process	carboxymethylenebutenolidase activity	mitochondrion|cytoplasm
YNR072W	YNR072W	HXT17	hom	Verified	0.40266128471693	0.343598709314456	no	1629	0.337472522658924	1153	NA	FT		PLASMA MEMBRANE		Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose	hexose transport	mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YOR078W	YOR078W	BUD21	hom	Verified	0.401883022891666	0.343885058789815	no	1630	0.33353372240095	1105	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|90S preribosome
YDL169C	YDL169C	UGX2	hom	Verified	0.401853500453353	0.343895922881519	no	1631	0.346965903403263	1156	NA					Protein of unknown function, transcript accumulates in response to any combination of stress conditions	biological_process	molecular_function	cellular_component
YBR036C	YBR036C	CSG2	hom	Verified	0.401734488259293	0.343939720008374	no	1632	0.359708984365646	1189	NA	FF|FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress	cellular calcium ion homeostasis|glycosphingolipid biosynthetic process	enzyme regulator activity	integral to endoplasmic reticulum membrane|integral to membrane
YBL096C_d	YBL096C	YBL096C	hom	Dubious	0.400400363527068	0.344430828266773	no	1633	0.333933961116743	1125	NA					Non-essential protein of unknown function	Unknown	Unknown	Unknown
YPR147C_p	YPR147C	YPR147C	hom	Uncharacterized	0.400137985966986	0.344527443680771	no	1634	0.347967431324038	1183	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cytoplasm
YGR290W_d	YGR290W	YGR290W	hom	Dubious	0.399974187968852	0.34458776423908	no	1635	0.357932458376896	1180	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)	Unknown	Unknown	Unknown
YOR136W	YOR136W	IDH2	hom	Verified	0.399877080954713	0.344623526916479	no	1636	0.366491512561685	1224	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated	glutamate biosynthetic process|isocitrate metabolic process|tricarboxylic acid cycle	isocitrate dehydrogenase (NAD+) activity	mitochondrial isocitrate dehydrogenase complex (NAD+)|mitochondrion|mitochondrial matrix
YDR333C	YDR333C	RQC1	hom	Verified	0.39912934236709	0.344898951397312	no	1637	0.331361972092525	1095	NA					Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC	biological_process	molecular_function	cytoplasm
YIL024C_p	YIL024C	YIL024C	hom	Uncharacterized	0.398730181726008	0.345046013200575	no	1638	0.341785855745936	1159	NA					Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p	biological_process	molecular_function	cellular_component
YNL145W	YNL145W	MFA2	hom	Verified	0.398711926468386	0.345052739501513	no	1639	0.329020514542448	1114	NA	FT	SIGNALING	PLASMA MEMBRANE		Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YHR105W	YHR105W	YPT35	hom	Verified	0.39846424339152	0.345144005221092	no	1640	0.326277531577932	1068	NA					Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport	biological_process	phosphatidylinositol-3-phosphate binding	endosome
YML012W	YML012W	ERV25	hom	Verified	0.397742745538481	0.345409912495328	no	1641	0.32671675429449	1140	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	ER to Golgi transport vesicle
YOR089C	YOR089C	VPS21	hom	Verified	0.396954107163933	0.345700651635868	no	1642	0.380700725649909	1262	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	MITOCHONDRION		Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication	endocytosis|vacuole inheritance|protein targeting to vacuole	GTP binding|GTPase activity	mitochondrial outer membrane|late endosome|mitochondrion
YDL052C	YDL052C	SLC1	hom	Verified	0.396770807434591	0.345768239891782	no	1643	0.369065736578564	1214	NA	FT	LIPID METABOLISM			1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes	glycerophospholipid biosynthetic process	1-acylglycerol-3-phosphate O-acyltransferase activity	lipid particle
YNL160W	YNL160W	YGP1	hom	Verified	0.396747248979386	0.345776926976362	no	1644	0.347975058521753	1154	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS			Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p	cell wall assembly	molecular_function	extracellular region
YMR057C_d	YMR057C	YMR057C	hom	Dubious	0.395759148514101	0.346141358077934	no	1645	0.343869656277631	1132	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1	Unknown	Unknown	Unknown
YGL104C	YGL104C	VPS73	hom	Verified	0.395516184688169	0.346230989813682	no	1646	0.361673491567547	1200	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	MITOCHONDRION		Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family	transport|transmembrane transport|protein targeting to vacuole	substrate-specific transmembrane transporter activity	mitochondrion|integral to membrane
YMR183C	YMR183C	SSO2	hom	Verified	0.395053794244887	0.346401593969937	no	1647	0.332835498530344	1146	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p	Golgi to plasma membrane transport|ascospore-type prospore assembly|vesicle fusion	phosphatidic acid binding|SNAP receptor activity	endoplasmic reticulum|plasma membrane|prospore membrane|cytoplasm
YOR225W_d	YOR225W	YOR225W	hom	Dubious	0.394921589770134	0.346450378029098	no	1648	0.352974256417137	1201	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR026C	YCR026C	NPP1	hom	Verified	0.39444846781212	0.346624983070598	no	1649	0.373840113693065	1262	NA	FT	NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS			Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication	cellular response to phosphate starvation|phosphate-containing compound metabolic process|nucleoside triphosphate metabolic process	nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity	cellular_component
YLL017W	YLL017W	YLL017W	hom	pseudogene	0.394220861535949	0.346708992481608	no	1650	0.309816639087286	1040	NA	FT	SIGNALING			Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication	Ras protein signal transduction	Ras guanyl-nucleotide exchange factor activity	membrane
YBR195C	YBR195C	MSI1	hom	Verified	0.392384772044835	0.347386967951807	no	1651	0.340262856353337	1142	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase	DNA replication-dependent nucleosome assembly	histone binding	nucleus|CAF-1 complex|cytoplasm
YBR092C	YBR092C	PHO3	hom	Verified	0.39208070265266	0.347499292692061	no	1652	0.338783315245199	1130	NA					Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin	phosphate-containing compound metabolic process|thiamine-containing compound metabolic process	acid phosphatase activity	cell wall-bounded periplasmic space
YPL170W	YPL170W	DAP1	hom	Verified	0.391956131885151	0.347545313618455	no	1653	0.37650654850961	1260	NA	FT	LIPID METABOLISM			Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis	regulation of ergosterol biosynthetic process	heme binding	endosome|membrane
YML112W	YML112W	CTK3	hom	Verified	0.39158455132389	0.347682602201545	no	1654	0.387153823709641	1274	NA	FF|FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION	NUCLEUS		Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress	mRNA 3'-end processing|positive regulation of translational fidelity|positive regulation of transcription from RNA polymerase I promoter|positive regulation of DNA-dependent transcription, elongation|protein phosphorylation	cyclin-dependent protein kinase activity	nucleoplasm|nucleolus|carboxy-terminal domain protein kinase complex
YDR336W_p	YDR336W	YDR336W	hom	Uncharacterized	0.391311010615871	0.347783680579307	no	1655	0.356756811438005	1192	NA					Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene	biological_process	molecular_function	cellular_component
YMR244W_p	YMR244W	YMR244W	hom	Uncharacterized	0.391289570767557	0.347791603459254	no	1656	0.298550431735417	1000	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL261C_d	YPL261C	YPL261C	hom	Dubious	0.391118653598235	0.347854766553974	no	1657	0.348553421647674	1180	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W	Unknown	Unknown	Unknown
YEL038W	YEL038W	UTR4	hom	Verified	0.390910133665753	0.347931831611907	no	1658	0.314857309200906	1081	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus	L-methionine salvage from methylthioadenosine	acireductone synthase activity	nucleus|cytoplasm
YPL018W	YPL018W	CTF19	hom	Verified	0.390839546909204	0.347957920577191	no	1659	0.395254808844122	1291	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2	attachment of spindle microtubules to kinetochore|chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	COMA complex|condensed nuclear chromosome kinetochore|nucleus
YCR073W-A	YCR073W-A	SOL2	hom	Verified	0.389528782849091	0.348442511493268	no	1660	0.356479079577084	1216	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication	tRNA export from nucleus	molecular_function|6-phosphogluconolactonase activity	cytosol|cytoplasm
YBR045C	YBR045C	GIP1	hom	Verified	0.389198476116862	0.348564665324149	no	1661	0.358430377225541	1193	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p	ascospore wall assembly|regulation of phosphoprotein phosphatase activity	protein phosphatase type 1 regulator activity|protein phosphatase 1 binding	protein phosphatase type 1 complex|prospore membrane
YLR017W	YLR017W	MEU1	hom	Verified	0.38919557873122	0.348565736903009	no	1662	0.32992356082348	1099	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression	L-methionine salvage from methylthioadenosine|glutamate biosynthetic process	S-methyl-5-thioadenosine phosphorylase activity|mRNA binding	cytoplasm
YBR184W_p	YBR184W	YBR184W	hom	Uncharacterized	0.389195336624276	0.348565826444711	no	1663	0.342637044459516	1165	NA					Putative protein of unknown function; YBR184W is not an essential gene	biological_process	molecular_function	cellular_component
YOR253W	YOR253W	NAT5	hom	Verified	0.389120290926907	0.348593582021651	no	1664	0.351325625822133	1165	NA	FT			RIBOSOME	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatA complex|cytosolic ribosome
YMR054W	YMR054W	STV1	hom	Verified	0.389027266028624	0.348627988313311	no	1665	0.352080558429479	1165	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|late endosome|integral to membrane|Golgi apparatus
YBR199W	YBR199W	KTR4	hom	Verified	0.388182676202387	0.348940426181165	no	1666	0.314787365189877	1066	NA	FT	CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family	protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YCR037C	YCR037C	PHO87	hom	Verified	0.388027426008774	0.348997868808748	no	1667	0.355736665065889	1196	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication	phosphate ion transport|transmembrane transport	inorganic phosphate transmembrane transporter activity	integral to membrane|membrane
YHR149C	YHR149C	SKG6	hom	Verified	0.387035712076034	0.349364884926588	no	1668	0.352804465311321	1176	NA	FT		SITE OF POLARIZED GROWTH		Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p	biological_process	molecular_function	cell cortex|incipient cellular bud site|integral to membrane|cellular bud neck|cellular bud tip
YIL096C_p	YIL096C	YIL096C	hom	Uncharacterized	0.386793841121631	0.34945441855402	no	1669	0.342676335751755	1130	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleolus|nucleus
YER016W	YER016W	BIM1	hom	Verified	0.386614794354472	0.349520701881305	no	1670	0.34902747040979	1163	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CHROMOSOME|CYTOSKELETON	KINETOCHORE	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally	nuclear migration along microtubule|microtubule nucleation|microtubule depolymerization|negative regulation of microtubule depolymerization|positive regulation of microtubule polymerization|mitotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint	microtubule plus-end binding|protein homodimerization activity|structural constituent of cytoskeleton	spindle midzone|microtubule plus end|cytoplasmic microtubule|spindle pole body|kinetochore|spindle pole|spindle
YJL185C	YJL185C	ATG36	hom	Verified	0.385842969326432	0.349806484928814	no	1671	0.340941562872698	1132	NA					Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene	peroxisome degradation	molecular_function	peroxisome
YPL230W	YPL230W	USV1	hom	Verified	0.385802107380183	0.349821617223359	no	1672	0.321830611432906	1088	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to salt stress	sequence-specific DNA binding	nucleus
YDL216C	YDL216C	RRI1	hom	Verified	0.385730042240815	0.349848305493753	no	1673	0.349061630792714	1177	NA	FT	SIGNALING|PROTEOLYSIS	NUCLEUS		Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	metalloendopeptidase activity	signalosome
YMR161W	YMR161W	HLJ1	hom	Verified	0.385633644062317	0.349884006309215	no	1674	0.357565509276396	1195	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ	ER-associated protein catabolic process	ATPase activator activity	endoplasmic reticulum|endoplasmic reticulum membrane
YGL058W	YGL058W	RAD6	hom	Verified	0.384477101067489	0.35031243240747	no	1675	0.361376676305304	1197	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEOLYSIS|GENE SILENCING	NUCLEUS|CHROMOSOME		Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p	protein ubiquitination involved in ubiquitin-dependent protein catabolic process|histone monoubiquitination|protein monoubiquitination|error-free translesion synthesis|error-prone translesion synthesis|transcription from RNA polymerase II promoter|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of dipeptide transport|meiotic DNA double-strand break formation|ubiquitin-dependent protein catabolic process via the N-end rule pathway|double-strand break repair via homologous recombination|protein polyubiquitination|error-free postreplication DNA repair|chromatin silencing at telomere	ubiquitin-protein ligase activity	nuclear chromatin|proteasome complex|nucleus|cytoplasm
YNL326C	YNL326C	PFA3	hom	Verified	0.384146878082737	0.350434794148496	no	1676	0.364925117263923	1221	NA	FT	MEMBRANE ORGANIZATION			Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions	vacuole fusion, non-autophagic|protein palmitoylation	palmitoyltransferase activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YOR016C	YOR016C	ERP4	hom	Verified	0.383888689284582	0.350530474955869	no	1677	0.344851628196	1141	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane
YCR069W	YCR069W	CPR4	hom	Verified	0.3835762488892	0.350646273254835	no	1678	0.33148768735302	1129	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	membrane
YML041C	YML041C	VPS71	hom	Verified	0.382697185561679	0.350972150742925	no	1679	0.363312190227751	1222	NA	FF|FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|VACUOLAR TRANSPORT	NUCLEUS|CHROMOSOME		Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting	chromatin remodeling|protein targeting to vacuole|histone exchange	nucleosome binding	Swr1 complex|nucleus
YFR032C-B_p	YFR032C-B	YFR032C-B	hom	Uncharacterized	0.381968080063241	0.351242520573605	no	1680	0.336281021981174	1159	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YJL132W_p	YJL132W	YJL132W	hom	Uncharacterized	0.381146843421821	0.35154714502103	no	1681	0.355033119090904	1165	NA					Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene	biological_process	molecular_function	membrane
YOR158W	YOR158W	PET123	hom	Verified	0.379974296010972	0.351982247757671	no	1682	0.361679053988883	1196	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YER111C	YER111C	SWI4	hom	Verified	0.379818321741399	0.352040140493623	no	1683	0.34225957835706	1166	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS|CHROMOSOME		DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	SBF transcription complex|nuclear chromatin
YLR386W	YLR386W	VAC14	hom	Verified	0.379770946536942	0.352057725356422	no	1684	0.378773341752509	1286	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM			Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p	phosphatidylinositol biosynthetic process|positive regulation of kinase activity	protein binding, bridging	fungal-type vacuole membrane|PAS complex|extrinsic to vacuolar membrane
YIL029C_p	YIL029C	YIL029C	hom	Uncharacterized	0.379230968946605	0.35225817811627	no	1685	0.362594716187643	1225	NA					Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W	biological_process	molecular_function	integral to membrane
YPL240C	YPL240C	HSP82	hom	Verified	0.37889151509263	0.352384212627028	no	1686	0.366873342871206	1248	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION			Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication	proteasome assembly|positive regulation of telomere maintenance via telomerase|box C/D snoRNP assembly|response to stress|protein refolding|protein targeting to mitochondrion|response to osmotic stress|'de novo' protein folding	unfolded protein binding|ATPase activity, coupled	cytoplasm
YDR383C	YDR383C	NKP1	hom	Verified	0.378604985214418	0.352490609816629	no	1687	0.369035494080002	1221	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CHROMOSOME	KINETOCHORE	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4	biological_process	molecular_function	kinetochore
YMR067C	YMR067C	UBX4	hom	Verified	0.378310100364528	0.352600121511784	no	1688	0.376907185001121	1251	NA	FT	PROTEOLYSIS	NUCLEUS		UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process|sporulation resulting in formation of a cellular spore	protein complex binding	nucleus|cytoplasm|extrinsic to membrane
YEL014C_d	YEL014C	YEL014C	hom	Dubious	0.377809258065836	0.35278614783303	no	1689	0.336348464842712	1101	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR272W-B_p	YMR272W-B	YMR272W-B	hom	Uncharacterized	0.377577400132151	0.352872278038532	no	1690	0.313464578429137	1078	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YMR082C_d	YMR082C	YMR082C	hom	Dubious	0.377396879961548	0.352939342597035	no	1691	0.368279793919704	1208	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL139C	YPL139C	UME1	hom	Verified	0.377203733294448	0.353011103050594	no	1692	0.355177713934016	1175	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter|regulation of meiosis	transcription corepressor activity	Rpd3S complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YHR051W	YHR051W	COX6	hom	Verified	0.376568082787027	0.353247305400894	no	1693	0.349816563730116	1165	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YDL065C	YDL065C	PEX19	hom	Verified	0.376385177209249	0.3533152820459	no	1694	0.35022619097892	1169	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning	protein stabilization|protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization|protein exit from endoplasmic reticulum	peroxisome membrane targeting sequence binding|protein binding	cytosol|peroxisomal membrane|endoplasmic reticulum
YML113W	YML113W	DAT1	hom	Verified	0.376058043836006	0.353436872452076	no	1695	0.342310223697859	1146	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability	negative regulation of transcription from RNA polymerase II promoter	AT DNA binding	nucleus
YML078W	YML078W	CPR3	hom	Verified	0.375864795406247	0.353508706928435	no	1696	0.361579064796261	1212	NA	FT		MITOCHONDRION		Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria	protein folding|apoptotic process	peptidyl-prolyl cis-trans isomerase activity	mitochondrion
YGR008C	YGR008C	STF2	hom	Verified	0.375795737525725	0.353534378450152	no	1697	0.356188855807979	1209	NA	FT		MITOCHONDRION		Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress	cellular response to desiccation	molecular_function	cytoplasm
YDR446W	YDR446W	ECM11	hom	Verified	0.375580350620056	0.353614450486513	no	1698	0.323433643520573	1066	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	NUCLEUS		Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure	fungal-type cell wall organization|reciprocal meiotic recombination	molecular_function	nucleus
YDR001C	YDR001C	NTH1	hom	Verified	0.375276353247877	0.35372747529028	no	1699	0.349955322346925	1194	NA	FT	CARBOHYDRATE METABOLISM			Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication	trehalose catabolic process|response to stress	alpha,alpha-trehalase activity	cytosol|cytoplasm
YIL011W	YIL011W	TIR3	hom	Verified	0.375155585603698	0.353772379715981	no	1700	0.324527434642566	1085	NA					Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth	biological_process	molecular_function	fungal-type cell wall
YBR208C	YBR208C	DUR1,2	hom	Verified	0.374807379075318	0.353901862985838	no	1701	0.347464554836584	1161	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress	allantoin catabolic process|urea catabolic process	urea carboxylase activity|allophanate hydrolase activity	cytoplasm
YLR173W_p	YLR173W	YLR173W	hom	Uncharacterized	0.37459551679902	0.35398065386954	no	1702	0.358377858671525	1190	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR196C	YOR196C	LIP5	hom	Verified	0.373922217429562	0.354231093190579	no	1703	0.367970250526482	1223	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase	protein lipoylation	lipoate synthase activity	mitochondrion
YGL199C_d	YGL199C	YGL199C	hom	Dubious	0.372983790290961	0.354580254171477	no	1704	0.33263015603788	1112	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W	Unknown	Unknown	Unknown
YDR421W	YDR421W	ARO80	hom	Verified	0.37293067066835	0.354600022069688	no	1705	0.329983537068679	1119	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids	aromatic amino acid family catabolic process|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|nucleic acid binding transcription factor activity	nucleus
YHR109W	YHR109W	CTM1	hom	Verified	0.372374660080908	0.354806958943107	no	1706	0.337786902269893	1098	NA					Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth	peptidyl-lysine methylation	[cytochrome c]-lysine N-methyltransferase activity	cytosol
YHL001W	YHL001W	RPL14B	hom	Verified	0.372336579221591	0.354821133504244	no	1707	0.343982980792068	1152	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YNL321W	YNL321W	VNX1	hom	Verified	0.372109108637699	0.354905807409566	no	1708	0.362202821512086	1183	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate	potassium ion transport|sodium ion transport|hydrogen transport	potassium:hydrogen antiporter activity|sodium:hydrogen antiporter activity|calcium:hydrogen antiporter activity	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum membrane|fungal-type vacuole
YLR412C-A_p	YLR412C-A	YLR412C-A	hom	Uncharacterized	0.371239555636742	0.355229556829942	no	1709	0.358173623764794	1170	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR094W	YBR094W	PBY1	hom	Verified	0.371192860517712	0.355246945178725	no	1710	0.344653020031701	1170	NA					Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|biological_process	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YGL043W	YGL043W	DST1	hom	Verified	0.371135935372329	0.35526814339685	no	1711	0.357437316016665	1172	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION	NUCLEUS		General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress	transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|mRNA cleavage|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|tRNA transcription from RNA polymerase III promoter|regulation of mRNA 3'-end processing|positive regulation of transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|transcription antitermination|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter	RNA polymerase II regulatory region DNA binding|RNA polymerase II core binding|core RNA polymerase II recruiting transcription factor activity	nucleus
YJR066W	YJR066W	TOR1	hom	Verified	0.37027025852875	0.355590565873835	no	1712	0.338435956995006	1140	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS|PLASMA MEMBRANE		PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication	regulation of cell cycle|G1 phase of mitotic cell cycle|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell growth|response to DNA damage stimulus|mitochondria-nucleus signaling pathway|ribosome biogenesis|meiosis|signal transduction|TOR signaling cascade|fungal-type cell wall organization|negative regulation of autophagy	protein binding|protein kinase activity	TORC1 complex|fungal-type vacuole membrane|endosome membrane|extrinsic to internal side of plasma membrane|plasma membrane|nucleus|Golgi membrane|cytoplasm
YPR062W	YPR062W	FCY1	hom	Verified	0.3693866159477	0.355919786315884	no	1713	0.369360848745009	1205	NA	FT		NUCLEUS		Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)	cytosine metabolic process|pyrimidine-containing compound salvage|cytidine metabolic process	cytosine deaminase activity	nucleus|cytoplasm
YDR252W	YDR252W	BTT1	hom	Verified	0.369030951554691	0.356052327241352	no	1714	0.35602402131713	1192	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3	'de novo' cotranslational protein folding	unfolded protein binding	nascent polypeptide-associated complex|CCR4-NOT complex
YHR087W	YHR087W	RTC3	hom	Verified	0.368965760704362	0.356076622973422	no	1715	0.373039641824364	1259	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress	RNA metabolic process	molecular_function	nucleus|cytoplasm
YAR050W	YAR050W	FLO1	hom	Verified	0.368683515593824	0.356181818579993	no	1716	0.370626087201721	1209	NA	FT		PLASMA MEMBRANE		Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p	cellular response to stress|flocculation via cell wall protein-carbohydrate interaction|flocculation	mannose binding	fungal-type cell wall
YER072W	YER072W	VTC1	hom	Verified	0.368289677180569	0.356328624432395	no	1717	0.360421511753477	1180	NA	FT	MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress	polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic	mRNA binding	integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex|intrinsic to vacuolar membrane
YJL142C_d	YJL142C	IRC9	hom	Dubious	0.368020797325187	0.3564288633959	no	1718	0.335017134125775	1151	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci	Unknown	Unknown	Unknown
YCR081W	YCR081W	SRB8	hom	Verified	0.367817759088933	0.356504563041963	no	1719	0.370367843475825	1233	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity	mediator complex
YIR029W	YIR029W	DAL2	hom	Verified	0.367155812338936	0.356751398831733	no	1720	0.345789270510856	1134	NA					Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process	allantoicase activity	cellular_component
YJL179W	YJL179W	PFD1	hom	Verified	0.366125062383227	0.357135878439546	no	1721	0.362153346775683	1196	NA	FT	CYTOSKELETON ORGANIZATION			Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin	protein folding|cytoskeleton organization	unfolded protein binding	prefoldin complex
YEL071W	YEL071W	DLD3	hom	Verified	0.365349186475768	0.357425383338011	no	1722	0.352917559136503	1170	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS			D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm	lactate metabolic process|filamentous growth	D-lactate dehydrogenase (cytochrome) activity	cytoplasm
YKR097W	YKR097W	PCK1	hom	Verified	0.365263167723804	0.357457484829202	no	1723	0.357333865548328	1185	NA	FT	CARBOHYDRATE METABOLISM			Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol	gluconeogenesis	phosphoenolpyruvate carboxykinase (ATP) activity	cytosol
YLR332W	YLR332W	MID2	hom	Verified	0.362899109803608	0.358340125879277	no	1724	0.37804513212537	1271	NA	FT	RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p	UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|cell morphogenesis involved in conjugation|response to acid|response to osmotic stress	transmembrane signaling receptor activity	integral to plasma membrane|mating projection tip
YDR173C	YDR173C	ARG82	hom	Verified	0.362884076074651	0.358345741277948	no	1725	0.341556904819104	1131	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes	protein stabilization|negative regulation of transcription from RNA polymerase II promoter|phosphatidylinositol phosphorylation|regulation of arginine metabolic process|inositol phosphate biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	inositol-1,4,5-trisphosphate 3-kinase activity|inositol-1,4,5-trisphosphate 6-kinase activity|phosphatidylinositol 3-kinase activity|protein binding, bridging|inositol tetrakisphosphate 6-kinase activity|inositol tetrakisphosphate 3-kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity	nucleus
YDL040C	YDL040C	NAT1	hom	Verified	0.36107139613749	0.359023037727796	no	1726	0.338663780666342	1165	NA	FT		MITOCHONDRION	RIBOSOME	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	mitochondrion|NatA complex|cytosolic ribosome
YLR370C	YLR370C	ARC18	hom	Verified	0.36031229253288	0.359306803857561	no	1727	0.406162882149045	1358	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION	MITOCHONDRION|CYTOSKELETON		Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches	mitochondrion inheritance|actin filament organization|establishment of mitochondrion localization	molecular_function	mitochondrion|Arp2/3 protein complex
YER096W	YER096W	SHC1	hom	Verified	0.360198505692629	0.35934934605081	no	1728	0.36797196565076	1203	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication	ascospore formation|chitin biosynthetic process	enzyme activator activity	prospore membrane
YBR046C	YBR046C	ZTA1	hom	Verified	0.359827353758324	0.359488123048579	no	1729	0.36470870173281	1203	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin	cellular response to oxidative stress	NADPH:quinone reductase activity|AU-rich element binding|2-alkenal reductase [NAD(P)] activity	nucleus|cytoplasm
YPL123C	YPL123C	RNY1	hom	Verified	0.359751836218444	0.359516361995902	no	1730	0.344773896533804	1155	NA					Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity	cell morphogenesis|RNA catabolic process|apoptotic process	endoribonuclease activity	cytosol|extracellular region|vacuole
YBR157C	YBR157C	ICS2	hom	Verified	0.359654455596976	0.359552777532838	no	1731	0.352279740231388	1184	NA					Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization	biological_process	molecular_function	cellular_component
YOR173W	YOR173W	DCS2	hom	Verified	0.359223227554461	0.359714050821454	no	1732	0.354630984091457	1230	NA					Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance	deadenylation-dependent decapping of nuclear-transcribed mRNA	m7G(5')pppN diphosphatase activity	cytoplasmic mRNA processing body|cytoplasm
YDL054C	YDL054C	MCH1	hom	Verified	0.358899206747344	0.359835246536352	no	1733	0.3636249086816	1256	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|membrane
YPR074C	YPR074C	TKL1	hom	Verified	0.35818925697578	0.360100843155564	no	1734	0.39694571479675	1301	NA	FF|FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication	pentose-phosphate shunt	transketolase activity	cytoplasm
YGR222W	YGR222W	PET54	hom	Verified	0.356550156333928	0.360714298698464	no	1735	0.363246007199192	1207	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing	Group I intron splicing|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	translation regulator activity|RNA binding	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial inner membrane|mitochondrial matrix
YMR224C	YMR224C	MRE11	hom	Verified	0.356179258643242	0.360853161973699	no	1736	0.369949724874268	1231	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress	DNA repair|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|base-excision repair|ascospore formation|meiotic DNA double-strand break processing|double-strand break repair via break-induced replication|regulation of transcription during meiosis	3'-5' exonuclease activity|protein complex scaffold|double-stranded telomeric DNA binding|adenylate kinase activity|telomeric DNA binding|single-stranded telomeric DNA binding|endodeoxyribonuclease activity|G-quadruplex DNA binding|endonuclease activity	mitochondrion|nucleus|Mre11 complex
YMR077C	YMR077C	VPS20	hom	Verified	0.355848139358806	0.360977147802135	no	1737	0.385978589432397	1288	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes	intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	protein binding	ESCRT III complex|cytoplasm
YPR106W	YPR106W	ISR1	hom	Verified	0.355799364531011	0.360995412507909	no	1738	0.344694524057451	1134	NA	FT	PROTEIN PHOSPHORYLATION			Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C	biological_process	protein kinase activity	cellular_component
YGL257C	YGL257C	MNT2	hom	Verified	0.355781467909335	0.361002114333855	no	1739	0.365701363272335	1191	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans	protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	cellular_component
YPL260W	YPL260W	YPL260W	hom	Verified	0.355702474392328	0.3610316958904	no	1740	0.378396000674374	1282	NA	FT		NUCLEUS		Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YDL056W	YDL056W	MBP1	hom	Verified	0.355262852430073	0.361196341061264	no	1741	0.346311596101804	1147	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes	positive regulation of transcription involved in G1/S phase of mitotic cell cycle	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	MBF transcription complex|nucleus
YLR042C_p	YLR042C	YLR042C	hom	Uncharacterized	0.354697683630427	0.361408043226678	no	1742	0.349286930083006	1149	NA					Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene	biological_process	molecular_function	fungal-type cell wall
YKL156W	YKL156W	RPS27A	hom	Verified	0.354259150138666	0.361572339307782	no	1743	0.371343857052324	1225	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasm
YBR210W	YBR210W	ERV15	hom	Verified	0.353597086768357	0.361820428957391	no	1744	0.346989661268685	1134	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION			Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|axial cellular bud site selection	molecular_function	integral to membrane|ER to Golgi transport vesicle
YER144C	YER144C	UBP5	hom	Verified	0.353561759846471	0.361833668362198	no	1745	0.3656113027755	1218	NA	FT	PROTEOLYSIS	SITE OF POLARIZED GROWTH		Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck	protein deubiquitination	ubiquitin-specific protease activity	incipient cellular bud site|cellular bud neck
YGL211W	YGL211W	NCS6	hom	Verified	0.353328470829738	0.361921101804113	no	1746	0.361886963326531	1239	NA	FT	RNA PROCESSING	MITOCHONDRION		Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	tRNA wobble position uridine thiolation|protein urmylation|tRNA wobble uridine modification	tRNA binding	cytosol|mitochondrion
YOL016C	YOL016C	CMK2	hom	Verified	0.353166652332522	0.361981753334341	no	1747	0.373162239228528	1217	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication	signal transduction|protein phosphorylation	protein kinase activity|calmodulin-dependent protein kinase activity	cytoplasm
YGL042C_d	YGL042C	YGL042C	hom	Dubious	0.352250250721436	0.362325297101517	no	1748	0.363261666161	1233	NA					Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1	Unknown	Unknown	Unknown
YGL085W_p	YGL085W	LCL3	hom	Uncharacterized	0.352095643592047	0.362383267692139	no	1749	0.352095067093132	1198	NA	FT		MITOCHONDRION		Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	mitochondrion
YBR177C	YBR177C	EHT1	hom	Verified	0.351988249202894	0.362423537525571	no	1750	0.353844654357573	1185	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication	medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process|cellular lipid metabolic process	short-chain carboxylesterase activity|alcohol O-butanoyltransferase activity|serine hydrolase activity	mitochondrial outer membrane|mitochondrion|lipid particle
YJR038C_d	YJR038C	YJR038C	hom	Dubious	0.351827517586891	0.362483810142059	no	1751	0.358031825425393	1218	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIR027C	YIR027C	DAL1	hom	Verified	0.350213155292064	0.363089367342766	no	1752	0.37343909808596	1246	NA					Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression	allantoin assimilation pathway	allantoinase activity	cellular_component
YBR299W	YBR299W	MAL32	hom	Verified	0.349122522407439	0.363498664345003	no	1753	0.364207651223239	1228	NA	FT	CARBOHYDRATE METABOLISM			Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose	sucrose catabolic process|maltose catabolic process	sucrose alpha-glucosidase activity|alpha-glucosidase activity|maltose alpha-glucosidase activity	plasma membrane
YAL004W_d	YAL004W	YAL004W	hom	Dubious	0.348981988732356	0.36355141572156	no	1754	0.377763497757458	1270	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C	Unknown	Unknown	Unknown
YGR199W	YGR199W	PMT6	hom	Verified	0.347941903990795	0.363941907156024	no	1755	0.368671969739136	1222	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases	protein O-linked glycosylation|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane
YLR015W	YLR015W	BRE2	hom	Verified	0.347611609371894	0.364065943195867	no	1756	0.381860458556664	1258	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L	histone H3-K4 methylation|telomere maintenance|histone H3-K4 trimethylation|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YPL021W	YPL021W	ECM23	hom	Verified	0.347354148404564	0.364162637781957	no	1757	0.340524602841304	1134	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p	pseudohyphal growth	sequence-specific DNA binding	cellular_component
YCR032W	YCR032W	BPH1	hom	Verified	0.347292630985802	0.364185743152113	no	1758	0.367960233685617	1236	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting	intracellular protein transport|fungal-type cell wall organization|response to pH	molecular_function	cytosol|mitochondrion|extrinsic to membrane
YDL190C	YDL190C	UFD2	hom	Verified	0.346323697403494	0.364549730659993	no	1759	0.37010504540326	1227	NA	FT	PROTEOLYSIS	NUCLEUS		Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3	ER-associated protein catabolic process|protein ubiquitination|ubiquitin-dependent protein catabolic process|response to stress	ubiquitin-ubiquitin ligase activity	nucleus|cytoplasm
YDL162C_d	YDL162C	YDL162C	hom	Dubious	0.345650343776513	0.364802753201421	no	1760	0.370014844766562	1213	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly	Unknown	Unknown	Unknown
YBL102W	YBL102W	SFT2	hom	Verified	0.345544349146344	0.364842587612451	no	1761	0.380948113944488	1276	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5	Golgi to endosome transport	molecular_function	integral to membrane|Golgi membrane
YLR001C_p	YLR001C	YLR001C	hom	Uncharacterized	0.345226844705809	0.364961919390195	no	1762	0.345813233353892	1153	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated	biological_process	molecular_function	mitochondrion|fungal-type vacuole membrane
YNL196C_p	YNL196C	SLZ1	hom	Uncharacterized	0.34458018175809	0.365205003483668	no	1763	0.372392681738947	1271	NA					Sporulation-specific protein with a leucine zipper motif	biological_process	molecular_function	cellular_component
YJR044C	YJR044C	VPS55	hom	Verified	0.343716664007587	0.365529688919785	no	1764	0.360759989687689	1198	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)	late endosome to vacuole transport via multivesicular body sorting pathway	molecular_function	Vps55/Vps68 complex|late endosome|integral to membrane
YER110C	YER110C	KAP123	hom	Verified	0.343464253900696	0.365624614140924	no	1765	0.335054258046693	1157	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1	NLS-bearing substrate import into nucleus|Unknown|protein import into nucleus|ribosomal protein import into nucleus	protein transporter activity|nuclear localization sequence binding	integral to membrane|nucleus|nuclear pore|cytoplasm
YER103W	YER103W	SSA4	hom	Verified	0.343450985721384	0.365629604203919	no	1766	0.357202787864806	1214	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity	nucleus|cytoplasm
YCR082W	YCR082W	AHC2	hom	Verified	0.341941938442837	0.366197293775161	no	1767	0.363350653239802	1238	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex	histone acetylation	histone acetyltransferase activity	Ada2/Gcn5/Ada3 transcription activator complex|nucleus|cytoplasm
YDL175C	YDL175C	AIR2	hom	Verified	0.341183284973099	0.366482802916785	no	1768	0.372166383873895	1256	NA	FT	RNA PROCESSING	NUCLEUS		RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication	nuclear polyadenylation-dependent CUT catabolic process|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|tRNA modification	polynucleotide adenylyltransferase activity|RNA binding|protein binding, bridging	nucleolus|TRAMP complex
YLR371W	YLR371W	ROM2	hom	Verified	0.340603519426698	0.366701039799337	no	1769	0.434134267134742	1434	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|NUCLEOTIDE METABOLISM	SITE OF POLARIZED GROWTH		GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p	regulation of fungal-type cell wall organization|positive regulation of endocytosis|establishment of cell polarity|small GTPase mediated signal transduction|negative regulation of cAMP-mediated signaling|activation of Rho GTPase activity	phosphatidylinositol-4,5-bisphosphate binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity	incipient cellular bud site|mating projection tip|cellular bud tip
YNL187W	YNL187W	SWT21	hom	Verified	0.340079634201773	0.366898279133614	no	1770	0.363795152358406	1225	NA	FT	RNA PROCESSING	NUCLEUS		Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats	mRNA splicing, via spliceosome	molecular_function	small nuclear ribonucleoprotein complex|nucleus
YJL151C	YJL151C	SNA3	hom	Verified	0.339695318575654	0.367042993783409	no	1771	0.3648112682221	1211	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles	cellular protein catabolic process|endosome transport via multivesicular body sorting pathway	ubiquitin protein ligase binding	fungal-type vacuole lumen|integral to membrane
YOR193W	YOR193W	PEX27	hom	Verified	0.338901945245058	0.367341799491429	no	1772	0.365589656471127	1207	NA	FT	PEROXISOME ORGANIZATION			Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p	peroxisome organization	molecular_function	peroxisomal membrane
YJL178C	YJL178C	ATG27	hom	Verified	0.338882988502479	0.367348940093467	no	1773	0.354689290128584	1200	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site	vesicle organization|peroxisome degradation|protein localization to pre-autophagosomal structure|CVT pathway|autophagic vacuole assembly	phosphatidylinositol-3-phosphate binding	trans-Golgi network|mitochondrion|pre-autophagosomal structure|membrane
YER186C_p	YER186C	YER186C	hom	Uncharacterized	0.338600706769138	0.367455275049107	no	1774	0.361198655399594	1211	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR296C-A_p	YBR296C-A	YBR296C-A	hom	Uncharacterized	0.338476867805618	0.367501928143224	no	1775	0.376982583310895	1260	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YHR063C	YHR063C	PAN5	hom	Verified	0.338229135078191	0.367595260844344	no	1776	0.383532679676991	1260	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE	pantothenate biosynthetic process	2-dehydropantoate 2-reductase activity	cytoplasm
YAL047C	YAL047C	SPC72	hom	Verified	0.338136734159689	0.367630074667915	no	1777	0.373717326210466	1239	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization	microtubule nucleation|nuclear migration along microtubule|mitotic cell cycle spindle orientation checkpoint|mitotic spindle elongation|mitotic sister chromatid segregation	structural constituent of cytoskeleton	outer plaque of spindle pole body
YMR221C_p	YMR221C	YMR221C	hom	Uncharacterized	0.338057248583629	0.367660023258088	no	1778	0.366695238680891	1235	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy	biological_process	molecular_function	mitochondrion|integral to membrane|fungal-type vacuole
YGR228W_d	YGR228W	YGR228W	hom	Dubious	0.337601136321226	0.367831892874661	no	1779	0.374346713706221	1259	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C	Unknown	Unknown	Unknown
YMR291W	YMR291W	TDA1	hom	Verified	0.337354454041412	0.36792485731197	no	1780	0.350980960185772	1171	NA	FT	PROTEIN PHOSPHORYLATION	NUCLEUS		Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress	protein phosphorylation	protein kinase activity	nucleus|cytoplasm
YFR006W_p	YFR006W	YFR006W	hom	Uncharacterized	0.337214982017436	0.367977422023532	no	1781	0.363977464933072	1261	NA					Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene	biological_process	molecular_function	cytoplasm
YJR055W	YJR055W	HIT1	hom	Verified	0.337067619932204	0.368032963055403	no	1782	0.310130604412294	1056	NA	FT		NUCLEUS		Protein of unknown function, required for growth at high temperature	biological_process	molecular_function	nucleus|cytoplasm
YCR051W_p	YCR051W	YCR051W	hom	Uncharacterized	0.336966146600001	0.368071210138698	no	1783	0.356999096191714	1207	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YNL246W	YNL246W	VPS75	hom	Verified	0.336098250494004	0.368398388834697	no	1784	0.384773825123044	1265	NA	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress	double-strand break repair via nonhomologous end joining|nucleosome assembly|positive regulation of histone acetylation	histone binding|acetyltransferase activator activity	chromatin|nucleus
YIL148W	YIL148W	RPL40A	hom	Verified	0.335907160346518	0.368470438656521	no	1785	0.375907602805294	1240	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION	NUCLEUS	RIBOSOME	Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	cytoplasmic translation|protein ubiquitination|ribosome biogenesis	structural constituent of ribosome|protein tag	cytosolic large ribosomal subunit
YPL216W_p	YPL216W	YPL216W	hom	Uncharacterized	0.335368840037262	0.368673435164304	no	1786	0.370830779433883	1245	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Putative protein of unknown function; YPL216W is not an essential gene	biological_process	molecular_function	cellular_component
YOL051W	YOL051W	GAL11	hom	Verified	0.335124818018293	0.36876546609367	no	1787	0.416876334913164	1399	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|TFIIE-class binding transcription factor activity|RNA polymerase II activating transcription factor binding|TFIIE-class transcription factor binding|TFIIH-class transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity	core mediator complex
YBR058C-A	YBR058C-A	TSC3	hom	Verified	0.334228519619388	0.369103562335052	no	1788	0.460032269376648	1526	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis	3-keto-sphinganine metabolic process|sphingolipid biosynthetic process	enzyme activator activity	SPOTS complex
YDR142C	YDR142C	PEX7	hom	Verified	0.334003240039606	0.369188556870195	no	1789	0.395583929596736	1279	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)	protein import into peroxisome matrix, docking	peroxisome matrix targeting signal-2 binding	cytosol|peroxisome
YCR066W	YCR066W	RAD18	hom	Verified	0.333771347594623	0.369276053017997	no	1790	0.384518604812703	1295	NA	FF|FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA	protein monoubiquitination|error-free translesion synthesis|error-free postreplication DNA repair|error-prone translesion synthesis	ubiquitin-protein ligase activity|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding	nuclear chromatin|nucleus
YLR226W	YLR226W	BUR2	hom	Verified	0.332264698705516	0.369844696725933	no	1791	0.378170937136378	1228	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION	NUCLEUS		Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II	phosphorylation of RNA polymerase II C-terminal domain|positive regulation of histone ubiquitination|transcription, DNA-dependent|positive regulation of histone H3-K4 methylation|mitotic sister chromatid segregation	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YCL069W	YCL069W	VBA3	hom	Verified	0.332140350656682	0.369891641255688	no	1792	0.371866631259346	1238	NA					Permease of basic amino acids in the vacuolar membrane	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YDR005C	YDR005C	MAF1	hom	Verified	0.332072356879863	0.369917311444113	no	1793	0.37610535606338	1246	NA	FT		NUCLEUS		Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions	negative regulation of transcription from RNA polymerase III promoter	RNA polymerase III core binding	nucleolus|nucleus|cytoplasm
YMR026C	YMR026C	PEX12	hom	Verified	0.331951918321078	0.369962782917636	no	1794	0.384986080877966	1273	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder	protein import into peroxisome matrix	ubiquitin-protein ligase activity|protein binding	integral to peroxisomal membrane
YPR039W_d	YPR039W	YPR039W	hom	Dubious	0.331885640916982	0.369987806669654	no	1795	0.38381174567384	1283	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W	Unknown	Unknown	Unknown
YML035C	YML035C	AMD1	hom	Verified	0.331875318244085	0.369991704156195	no	1796	0.365785054493594	1224	NA	FT	NUCLEOTIDE METABOLISM			AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools	guanine salvage|purine nucleotide metabolic process	AMP deaminase activity	cytoplasm
YDR481C	YDR481C	PHO8	hom	Verified	0.330600408164753	0.370473168932554	no	1797	0.400362798141807	1325	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN	nicotinamide nucleotide metabolic process|protein dephosphorylation	nucleotide phosphatase activity|alkaline phosphatase activity	fungal-type vacuole membrane
YPL052W	YPL052W	OAZ1	hom	Verified	0.329249050416507	0.370983725449737	no	1798	0.366546164272988	1221	NA	FT	TRANSLATION|PROTEOLYSIS			Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p	Unknown|regulation of proteasomal protein catabolic process	ornithine decarboxylase inhibitor activity	cytoplasm
YBR188C	YBR188C	NTC20	hom	Verified	0.328983075937776	0.371084240063973	no	1799	0.369818232780388	1203	NA	FT	RNA PROCESSING	NUCLEUS		Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs	mRNA splicing, via spliceosome	first spliceosomal transesterification activity	Prp19 complex|U2-type catalytic step 1 spliceosome
YML001W	YML001W	YPT7	hom	Verified	0.328470198187098	0.371278086905396	no	1800	0.360608623272098	1186	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	MITOCHONDRION		Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7	regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole inheritance|Golgi to vacuole transport|vesicle-mediated transport|endocytosis	GTPase activity	mitochondrial outer membrane|fungal-type vacuole
YCL002C_p	YCL002C	YCL002C	hom	Uncharacterized	0.328071088119935	0.371428956807458	no	1801	0.374409817104888	1226	NA					Putative protein of unknown function; YCL002C is not an essential gene	biological_process	molecular_function	integral to membrane
YBR025C	YBR025C	OLA1	hom	Verified	0.327504502369826	0.371643169084628	no	1802	0.375055655000244	1231	NA					P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress	biological_process	ATPase activity	cytoplasm
YOR068C	YOR068C	VAM10	hom	Verified	0.326393292792162	0.372063405749615	no	1803	0.375476316790075	1247	NA	FT	MEMBRANE ORGANIZATION			Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering	vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane
YJL095W	YJL095W	BCK1	hom	Verified	0.326338244518347	0.372084227844254	no	1804	0.414117223042304	1357	NA	FF|FT	SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH		Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p	intracellular protein kinase cascade|endoplasmic reticulum unfolded protein response|peroxisome degradation|establishment of cell polarity|protein phosphorylation|response to acid|response to nutrient	protein kinase activity|MAP kinase kinase kinase activity	intracellular|mating projection tip
YNL109W_d	YNL109W	YNL109W	hom	Dubious	0.326191117411988	0.37213988073532	no	1805	0.378379236888753	1233	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C	Unknown	Unknown	Unknown
YOL097W-A_p	YOL097W-A	YOL097W-A	hom	Uncharacterized	0.32585248256159	0.372267984262726	no	1806	0.375611136888889	1223	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YLR036C_p	YLR036C	YLR036C	hom	Uncharacterized	0.324613095332065	0.372736957448104	no	1807	0.361287271254992	1235	NA					Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein	biological_process	molecular_function	integral to membrane
YCR011C	YCR011C	ADP1	hom	Verified	0.324483700202205	0.372785930313631	no	1808	0.356349409738618	1207	NA	FT	NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative ATP-dependent permease of the ABC transporter family of proteins	transport|transmembrane transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|endoplasmic reticulum|cytoplasm
YLR200W	YLR200W	YKE2	hom	Verified	0.324426535064533	0.372807566563362	no	1809	0.401022126772649	1331	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin	protein folding|tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YDR282C_p	YDR282C	YDR282C	hom	Uncharacterized	0.323390542708136	0.373199745458479	no	1810	0.356630127742909	1179	NA					Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation	biological_process	molecular_function	cellular_component
YOR279C	YOR279C	RFM1	hom	Verified	0.322003934189057	0.373724857037525	no	1811	0.39340293696215	1324	NA	FT	GENE SILENCING	NUCLEUS		DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance	chromatin silencing|chromatin silencing at silent mating-type cassette	unfolded protein binding	histone deacetylase complex|nucleus
YER087C-B	YER087C-B	SBH1	hom	Verified	0.32187038897719	0.373775443286719	no	1812	0.400084943846702	1328	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p	posttranslational protein targeting to membrane, translocation|SRP-dependent cotranslational protein targeting to membrane, translocation	ARF guanyl-nucleotide exchange factor activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity	Sec61 translocon complex
YDR466W	YDR466W	PKH3	hom	Verified	0.320991729990555	0.374108329037816	no	1813	0.403794056059742	1355	NA	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION			Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant	MAPK cascade involved in cell wall biogenesis|protein phosphorylation	protein kinase activity	cellular_component
YPR115W	YPR115W	RGC1	hom	Verified	0.320462084325999	0.374309034166076	no	1814	0.380654036523489	1243	NA	FT	CELL CYCLE			Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication	positive regulation of glycerol transport	molecular_function	cytoplasm
YNL194C	YNL194C	YNL194C	hom	Verified	0.320284889949293	0.374376188212692	no	1815	0.366345898560022	1227	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate	ascospore formation	molecular_function	cell cortex|integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YEL007W	YEL007W	MIT1	hom	Verified	0.319895216828772	0.374523881962989	no	1816	0.356320183616649	1197	NA	FT		NUCLEUS		Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1	biological_process	molecular_function	nucleus|cytoplasm
YLR038C	YLR038C	COX12	hom	Verified	0.319833690456667	0.374547203347501	no	1817	0.362902129455435	1214	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV	mitochondrial respiratory chain complex IV assembly	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YEL053C	YEL053C	MAK10	hom	Verified	0.318790868573153	0.374942551560066	no	1818	0.374137976599487	1249	NA					Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex|cytoplasm
YJR146W_p	YJR146W	YJR146W	hom	Uncharacterized	0.318714716965961	0.37497142684336	no	1819	0.370982214631041	1241	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2	biological_process	molecular_function	cellular_component
YLL001W	YLL001W	DNM1	hom	Verified	0.31847996092237	0.375060446409968	no	1820	0.367594331256755	1225	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	MITOCHONDRION		Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance	mitochondrion inheritance|peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization|mitochondrion organization|protein homooligomerization	protein homodimerization activity|GTPase activity|identical protein binding	mitochondrial outer membrane|mitochondrion|peroxisome
YLR300W	YLR300W	EXG1	hom	Verified	0.31773427226575	0.375343255913862	no	1821	0.361797583486494	1208	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes	fungal-type cell wall organization|cellular glucan metabolic process	glucan exo-1,3-beta-glucosidase activity	extracellular region|fungal-type cell wall
YIL086C_d	YIL086C	YIL086C	hom	Dubious	0.317661368386737	0.375370909000708	no	1822	0.367970077496667	1207	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR253C_p	YMR253C	YMR253C	hom	Uncharacterized	0.317386175439532	0.375475297892459	no	1823	0.373605508755109	1263	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene	biological_process	molecular_function	integral to membrane|cytoplasm
YMR123W	YMR123W	PKR1	hom	Verified	0.317134255559951	0.375570866609704	no	1824	0.414177719070173	1359	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress	vacuolar proton-transporting V-type ATPase complex assembly	molecular_function	integral to endoplasmic reticulum membrane
YBR230C	YBR230C	OM14	hom	Verified	0.315729012147137	0.37610410187102	no	1825	0.385280924938815	1279	NA	FT		MITOCHONDRION		Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron	biological_process	molecular_function	mitochondrion|integral to mitochondrial outer membrane
YGL045W	YGL045W	RIM8	hom	Verified	0.315535256821472	0.376177643071388	no	1826	0.394466011575738	1285	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family	meiosis|protein processing|invasive growth in response to glucose limitation|ubiquitin-dependent endocytosis	molecular_function	internal side of plasma membrane
YGL237C	YGL237C	HAP2	hom	Verified	0.315504760208695	0.376189218685456	no	1827	0.370215742820193	1226	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex|nucleus
YEL030W	YEL030W	ECM10	hom	Verified	0.315031112882993	0.376369015522189	no	1828	0.359143164147927	1209	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog, SSC1, that arose from the whole genome duplication	protein refolding|protein targeting to mitochondrion	molecular_function	mitochondrial nucleoid|mitochondrion
YDR351W	YDR351W	SBE2	hom	Verified	0.314645501009946	0.376515413858111	no	1829	0.37753980096077	1254	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	GOLGI APPARATUS		Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth	fungal-type cell wall organization	molecular_function	Golgi apparatus
YOR237W	YOR237W	HES1	hom	Verified	0.314058372785534	0.376738352396292	no	1830	0.404201932026012	1340	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION			Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication	maintenance of cell polarity|endocytosis|exocytosis|sterol transport	lipid binding|oxysterol binding|sterol transporter activity	cellular_component
YJL163C_p	YJL163C	YJL163C	hom	Uncharacterized	0.313934294767235	0.376785471342024	no	1831	0.365409877844765	1192	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YDL032W_d	YDL032W	YDL032W	hom	Dubious	0.313096703570162	0.377103596729762	no	1832	0.412389000570331	1371	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene	Unknown	Unknown	Unknown
YMR135C	YMR135C	GID8	hom	Verified	0.312512475411358	0.377325541748482	no	1833	0.377603939676106	1230	NA	FT	KETONE METABOLISM|CELL CYCLE|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|traversing start control point of mitotic cell cycle	molecular_function	nucleus|GID complex|cytoplasm
YBR165W	YBR165W	UBS1	hom	Verified	0.312177070608247	0.377452978478182	no	1834	0.362640167611967	1204	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity	protein export from nucleus|protein ubiquitination	molecular_function	nucleus
YOR076C	YOR076C	SKI7	hom	Verified	0.311889138572801	0.377562388620991	no	1835	0.387504896489433	1252	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM			Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay|nonfunctional rRNA decay	protein binding, bridging	Ski complex|cytoplasmic exosome (RNase complex)|cytoplasm
YJR061W_p	YJR061W	YJR061W	hom	Uncharacterized	0.311772991750566	0.377606525569193	no	1836	0.385139727898511	1274	NA					Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YJR062C	YJR062C	NTA1	hom	Verified	0.310458994765099	0.378105968693355	no	1837	0.35601146804232	1191	NA	FT	PROTEOLYSIS	MITOCHONDRION		Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation	cellular protein modification process|protein catabolic process	protein-N-terminal asparagine amidohydrolase activity	mitochondrion
YNR067C	YNR067C	DSE4	hom	Verified	0.310456761205836	0.378106817830826	no	1838	0.325086413771652	1098	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION			Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother	cytokinesis, completion of separation	glucan endo-1,3-beta-D-glucosidase activity	fungal-type cell wall|extracellular region|cell septum
YNL133C	YNL133C	FYV6	hom	Verified	0.310425561502966	0.378118679156696	no	1839	0.399177315460145	1317	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining	double-strand break repair via nonhomologous end joining	molecular_function	nucleus
YDR359C	YDR359C	EAF1	hom	Verified	0.310188808773533	0.378208690207623	no	1840	0.4135535538402	1341	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1	DNA repair|cellular protein complex assembly|chromatin modification	molecular_function	histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YDR448W	YDR448W	ADA2	hom	Verified	0.310175036379515	0.378213926539393	no	1841	0.427288924678155	1415	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes	chromatin silencing at rDNA|chromatin modification|regulation of transcription from RNA polymerase II promoter|positive regulation of histone acetylation|chromatin silencing at telomere	chromatin binding|transcription coactivator activity|histone acetyltransferase activity|phosphatidylserine binding	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YGR164W_d	YGR164W	YGR164W	hom	Dubious	0.309630255226587	0.378421072939554	no	1842	0.377765025069393	1295	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL138W	YNL138W	SRV2	hom	Verified	0.309162254234732	0.378599052524533	no	1843	0.451506890352533	1480	NA	FT	SIGNALING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis	cytoskeleton organization|Ras protein signal transduction	cytoskeletal protein binding|adenylate cyclase binding	mating projection tip|actin cortical patch
YBR288C	YBR288C	APM3	hom	Verified	0.308724177681657	0.378765675258371	no	1844	0.391237332921807	1318	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway	Golgi to vacuole transport|vesicle-mediated transport	molecular_function	AP-3 adaptor complex
YGR270W	YGR270W	YTA7	hom	Verified	0.308359933620591	0.378904232910813	no	1845	0.407041965598581	1358	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p	negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter	chromatin binding|histone binding	extrinsic to endoplasmic reticulum membrane|nucleus
YBR059C	YBR059C	AKL1	hom	Verified	0.308064627542142	0.379016578128449	no	1846	0.38159639745265	1257	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization	regulation of endocytosis|protein phosphorylation|actin cytoskeleton organization	protein kinase activity	cellular bud neck|cytoplasm
YFR012W	YFR012W	DCV1	hom	Verified	0.306365760713809	0.37966308737873	no	1847	0.3726390960339	1215	NA					Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YPL269W	YPL269W	KAR9	hom	Verified	0.305300461500771	0.380068662238646	no	1848	0.428049382616846	1401	NA	FT		NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase	nuclear migration along microtubule|establishment of spindle localization	molecular_function	cell cortex|spindle pole body|mating projection tip
YBR191W	YBR191W	RPL21A	hom	Verified	0.304645368752305	0.380318131083588	no	1849	0.38365322258386	1260	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YEL029C	YEL029C	BUD16	hom	Verified	0.304637373345049	0.380321176158699	no	1850	0.398095690955749	1312	NA	FT	CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM	NUCLEUS		Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)	pyridoxal phosphate biosynthetic process|cellular bud site selection	pyridoxal kinase activity	cytoplasm
YDR283C	YDR283C	GCN2	hom	Verified	0.304350420732427	0.380430467840318	no	1851	0.41638100678666	1366	NA	FF|FT	KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION		RIBOSOME	Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control	cellular amino acid biosynthetic process|protein phosphorylation|regulation of translational initiation|DNA damage checkpoint	protein homodimerization activity|protein kinase activity|eukaryotic translation initiation factor 2alpha kinase activity	cytosolic ribosome
YDL177C_p	YDL177C	YDL177C	hom	Uncharacterized	0.303972210781123	0.380574531297379	no	1852	0.365187264946203	1216	NA					Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene	biological_process	molecular_function	cellular_component
YOL092W	YOL092W	YPQ1	hom	Verified	0.303069043171034	0.380918622656636	no	1853	0.375285261618	1236	NA					Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane|cytoplasm
YAL051W	YAL051W	OAF1	hom	Verified	0.302747719046783	0.381041064364894	no	1854	0.377896537516972	1227	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GENE SILENCING	NUCLEUS		Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication	cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YCR067C	YCR067C	SED4	hom	Verified	0.302582796344839	0.381103913377697	no	1855	0.379692751273282	1257	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p	positive regulation of GTPase activity|regulation of COPII vesicle coating	Sar GTPase activator activity	integral to endoplasmic reticulum membrane
YAL009W	YAL009W	SPO7	hom	Verified	0.302433386607157	0.381160853392533	no	1856	0.400137195103223	1319	NA	FF|FT	CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|integral to membrane
YMR192W	YMR192W	GYL1	hom	Verified	0.302226605757469	0.381239661768655	no	1857	0.375369146681284	1231	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress	ER to Golgi vesicle-mediated transport|regulation of exocytosis	protein binding	mitochondrion|incipient cellular bud site|cellular bud|cellular bud neck|cellular bud tip|cytoplasm|Golgi-associated vesicle|plasma membrane
YDR370C	YDR370C	DXO1	hom	Verified	0.301928367750426	0.381353334996339	no	1858	0.381999216043715	1261	NA					Protein with decapping and 5&#8242;-3&#8242; exoRNase activity; similar to Rai1p	biological_process	molecular_function	cytoplasm
YKR103W	YKR103W	NFT1	hom	Verified	0.301224625319664	0.381621606537333	no	1859	0.387428928291572	1280	NA	FT	NUCLEOTIDE METABOLISM			Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.	transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YIL007C	YIL007C	NAS2	hom	Verified	0.300690767982049	0.381825154635921	no	1860	0.356616020796424	1185	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress	proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|cytoplasm
YKL002W	YKL002W	DID4	hom	Verified	0.298690832953972	0.38258797609111	no	1861	0.382223470951488	1277	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis	protein retention in Golgi apparatus|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	molecular_function	ESCRT III complex|cytoplasm
YHR150W	YHR150W	PEX28	hom	Verified	0.29820136966276	0.382774738241972	no	1862	0.342384737101102	1154	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p	peroxisome organization	molecular_function	integral to membrane|peroxisomal membrane
YDL134C	YDL134C	PPH21	hom	Verified	0.297961726276607	0.382866187758426	no	1863	0.369444462168619	1198	NA	FT	CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION			Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication	actin filament organization|budding cell bud growth|protein dephosphorylation|G1/S transition of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|regulation of translation	protein serine/threonine phosphatase activity	protein phosphatase type 2A complex
YPL177C	YPL177C	CUP9	hom	Verified	0.297813311665053	0.382922827040014	no	1864	0.386454343334897	1299	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YLR375W	YLR375W	STP3	hom	Verified	0.297070278330902	0.383206427535872	no	1865	0.392455116939013	1266	NA	FT		NUCLEUS		Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids	biological_process	sequence-specific DNA binding	nucleus
YBR082C	YBR082C	UBC4	hom	Verified	0.296991981339408	0.383236315531028	no	1866	0.355815838823723	1169	NA	FT	PROTEOLYSIS			Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress	ubiquitin binding|ubiquitin-protein ligase activity	proteasome complex
YDL018C	YDL018C	ERP3	hom	Verified	0.296867749849551	0.383283739343366	no	1867	0.39105527457595	1280	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YMR158W	YMR158W	MRPS8	hom	Verified	0.296819148431167	0.383302292800969	no	1868	0.384513891708912	1274	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YOR213C	YOR213C	SAS5	hom	Verified	0.295675623410323	0.383738907475472	no	1869	0.408487935000049	1353	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity	chromatin silencing at telomere	acetyltransferase activity|histone acetyltransferase activity	nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YKR078W	YKR078W	YKR078W	hom	Verified	0.295559457167244	0.383783269726084	no	1870	0.391205170373472	1286	NA					Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)	biological_process	phosphatidylinositol-3-phosphate binding	cytoplasm
YPL162C_p	YPL162C	YPL162C	hom	Uncharacterized	0.295548711101611	0.383787373574036	no	1871	0.38506173776856	1289	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YHR155W	YHR155W	YSP1	hom	Verified	0.295091167500095	0.383962118389014	no	1872	0.395690081566442	1316	NA	FF|FT		MITOCHONDRION		Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion
YNL139C	YNL139C	THO2	hom	Verified	0.294875659770215	0.384044433165544	no	1873	0.417149366765049	1351	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	NUCLEUS		Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids	mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|DNA recombination|transcription elongation from RNA polymerase II promoter	DNA binding|nucleic acid binding	THO complex part of transcription export complex|nucleus|nucleoplasmic THO complex
YLR264C-A_p	YLR264C-A	YLR264C-A	hom	Uncharacterized	0.294292015668148	0.38426738661836	no	1874	0.381819336559965	1249	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBL091C	YBL091C	MAP2	hom	Verified	0.29422601726127	0.384292600580285	no	1875	0.386691435623047	1281	NA	FT	PROTEOLYSIS			Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p	protein initiator methionine removal involved in protein maturation	metalloaminopeptidase activity	cytoplasm
YLR089C	YLR089C	ALT1	hom	Verified	0.293866239012064	0.384430058491002	no	1876	0.389797950716064	1276	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive	alanine catabolic process|alanine biosynthetic process	L-alanine:2-oxoglutarate aminotransferase activity	mitochondrion
YGR146C	YGR146C	ECL1	hom	Verified	0.293529063254152	0.384558894022147	no	1877	0.394608636193066	1291	NA					Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	cellular_component
YJL133W	YJL133W	MRS3	hom	Verified	0.293380858100493	0.384615527542725	no	1878	0.366012780996234	1206	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication	mitochondrial iron ion transport|RNA splicing	iron ion transmembrane transporter activity	mitochondrion|integral to membrane
YHR061C	YHR061C	GIC1	hom	Verified	0.293257358518949	0.384662722223194	no	1879	0.384180817694053	1264	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress	regulation of exit from mitosis|establishment of cell polarity|axial cellular bud site selection|Rho protein signal transduction	Rho GTPase binding|Rho GTPase activator activity	incipient cellular bud site|actin cap|mating projection tip|cellular bud neck|cellular bud tip
YDR524C-B_p	YDR524C-B	YDR524C-B	hom	Uncharacterized	0.292943846062641	0.384782536946101	no	1880	0.399014823496522	1361	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDL077C	YDL077C	VAM6	hom	Verified	0.292574855270275	0.384923567862798	no	1881	0.413873185188059	1354	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION			Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle-mediated transport|vacuole organization|vacuole fusion, non-autophagic	Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding	fungal-type vacuole membrane|HOPS complex|fungal-type vacuole
YPR170C_d	YPR170C	YPR170C	hom	Dubious	0.292501446405275	0.384951627071853	no	1882	0.436797272877789	1427	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B	Unknown	Unknown	Unknown
YOL023W	YOL023W	IFM1	hom	Verified	0.292496410346804	0.384953552036076	no	1883	0.40105224097717	1302	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation initiation factor 2	translational initiation|mitochondrial translational initiation|mitochondrial translation	tRNA binding|GTPase activity|translation initiation factor activity	mitochondrion
YIL041W	YIL041W	GVP36	hom	Verified	0.292451044862958	0.384970892497376	no	1884	0.39693492376495	1320	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis	vacuole organization|endocytosis|establishment or maintenance of actin cytoskeleton polarity	molecular_function	integral to Golgi membrane|cytoplasm
YJL144W	YJL144W	YJL144W	hom	Verified	0.291867170568611	0.385194092600369	no	1885	0.380280590475723	1253	NA					Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress	cellular response to water deprivation	molecular_function	cytoplasm
YNR041C	YNR041C	COQ2	hom	Verified	0.291844585112696	0.38520272720303	no	1886	0.385807252165829	1293	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis	ubiquinone biosynthetic process	4-hydroxybenzoate octaprenyltransferase activity	mitochondrion|integral to mitochondrial membrane|integral to membrane
YCL030C	YCL030C	HIS4	hom	Verified	0.291363557148449	0.385386641596592	no	1887	0.393042632137939	1297	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis	histidine biosynthetic process	phosphoribosyl-ATP diphosphatase activity|phosphoribosyl-AMP cyclohydrolase activity|histidinol dehydrogenase activity	intracellular
YAL049C	YAL049C	AIM2	hom	Verified	0.291351263943616	0.385391342071527	no	1888	0.382801419151856	1273	NA					Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor	biological_process	molecular_function	cytoplasm
YPR089W_p	YPR089W	YPR089W	hom	Uncharacterized	0.290764345214251	0.385615778049461	no	1889	0.388403521676932	1295	NA	FT		GOLGI APPARATUS		Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p	biological_process	molecular_function	cellular_component
YNL329C	YNL329C	PEX6	hom	Verified	0.290450671597063	0.38573574161914	no	1890	0.388401896419065	1288	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol	protein import into peroxisome matrix, receptor recycling|replicative cell aging	ATPase activity|protein heterodimerization activity	cytosol|peroxisome
YML006C	YML006C	GIS4	hom	Verified	0.289782003211853	0.385991508384164	no	1891	0.388360153244646	1281	NA	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway	cellular ion homeostasis|intracellular signal transduction	molecular_function	plasma membrane
YDR123C	YDR123C	INO2	hom	Verified	0.289229044359493	0.386203053506836	no	1892	0.391922361402709	1292	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion	phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YKL054C	YKL054C	DEF1	hom	Verified	0.288227597287663	0.386586262575595	no	1893	0.389442743129749	1309	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS|CHROMOSOME		RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis	transcription-coupled nucleotide-excision repair|telomere maintenance|response to DNA damage stimulus|ubiquitin-dependent protein catabolic process	molecular_function	nucleus
YOR115C	YOR115C	TRS33	hom	Verified	0.288121897005828	0.386626715813329	no	1894	0.381622013148861	1271	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS	ENDOPLASMIC RETICULUM|GOLGI APPARATUS		One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic	ER to Golgi vesicle-mediated transport|protein complex assembly	molecular_function	trans-Golgi network|TRAPP complex|cis-Golgi network
YJL062W	YJL062W	LAS21	hom	Verified	0.287870547556753	0.386722916332133	no	1895	0.391251034929843	1299	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity	GPI anchor biosynthetic process	mannose-ethanolamine phosphotransferase activity|transferase activity	integral to endoplasmic reticulum membrane|integral to membrane|integral to plasma membrane
YKL181W	YKL181W	PRS1	hom	Verified	0.287373843336452	0.386913043454298	no	1896	0.386921313041599	1291	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YPR166C	YPR166C	MRP2	hom	Verified	0.287341001796763	0.386925615408684	no	1897	0.399151445995692	1335	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YGR012W	YGR012W	YGR012W	hom	Verified	0.286177293148422	0.387371167115798	no	1898	0.379855362167123	1238	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Putative cysteine synthase, localized to the mitochondrial outer membrane	cysteine biosynthetic process	cysteine synthase activity	mitochondrial outer membrane|mitochondrion
YDR345C	YDR345C	HXT3	hom	Verified	0.284360319916966	0.388067132226276	no	1899	0.414245250056333	1366	NA	FT		PLASMA MEMBRANE		Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication	hexose transport|transmembrane transport	mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YIL079C	YIL079C	AIR1	hom	Verified	0.28420912193872	0.388125062647533	no	1900	0.385025497155975	1264	NA	FT	RNA PROCESSING	NUCLEUS		Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication	nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent snRNA catabolic process	polynucleotide adenylyltransferase activity	nucleolus|TRAMP complex
YOR220W	YOR220W	RCN2	hom	Verified	0.283952421105095	0.3882234214318	no	1901	0.383482470942593	1308	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cytoplasm
YJL117W	YJL117W	PHO86	hom	Verified	0.283714605256968	0.388314550547964	no	1902	0.359414921624637	1211	NA	FT	VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM		Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress	protein folding|ER to Golgi vesicle-mediated transport|regulation of phosphate transport	unfolded protein binding	endoplasmic reticulum
YJL051W	YJL051W	IRC8	hom	Verified	0.283675149089464	0.388329670428163	no	1903	0.378223612190147	1235	NA					Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc	mitotic recombination	molecular_function	integral to membrane|cellular bud
YBR062C_p	YBR062C	YBR062C	hom	Uncharacterized	0.282189156085309	0.388899236388746	no	1904	0.383350463362134	1270	NA					Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.	biological_process	molecular_function	cellular_component
YAR014C	YAR014C	BUD14	hom	Verified	0.280149444901645	0.389681425639231	no	1905	0.387643906351594	1317	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress	regulation of cell shape during vegetative growth phase|regulation of protein localization|regulation of transcription, DNA-dependent|cytoskeleton organization|negative regulation of actin filament polymerization	protein phosphatase type 1 regulator activity	incipient cellular bud site|cellular bud neck|cellular bud tip
YIL120W	YIL120W	QDR1	hom	Verified	0.280074241349549	0.389710273291411	no	1906	0.372047423524743	1248	NA	FT		PLASMA MEMBRANE		Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication	drug transmembrane transport	drug transmembrane transporter activity	integral to membrane|plasma membrane
YIL059C_d	YIL059C	YIL059C	hom	Dubious	0.279793924715073	0.389817806500329	no	1907	0.372686730964839	1222	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W	Unknown	Unknown	Unknown
YMR156C	YMR156C	TPP1	hom	Verified	0.279499715999801	0.389930677968641	no	1908	0.390156522223889	1291	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3&#8242;-phosphatase	DNA repair	polynucleotide 3'-phosphatase activity	cellular_component
YBR222C	YBR222C	PCS60	hom	Verified	0.278743962693509	0.390220660867778	no	1909	0.36845746349605	1206	NA					Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase	biological_process	mRNA binding|AMP binding	integral to membrane|peroxisomal matrix|peroxisomal membrane|cytoplasm
YOL013C	YOL013C	HRD1	hom	Verified	0.278425901142734	0.390342719509697	no	1910	0.385676699279531	1287	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon	fungal-type cell wall organization|ER-associated protein catabolic process	ubiquitin-protein ligase activity	Hrd1p ubiquitin ligase ERAD-M complex|integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YLR041W_d	YLR041W	YLR041W	hom	Dubious	0.278189710265732	0.390433366626081	no	1911	0.379879216791892	1270	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C	Unknown	Unknown	Unknown
YML054C-A_p	YML054C-A	YML054C-A	hom	Uncharacterized	0.277316144765869	0.390768681899983	no	1912	0.371831872739898	1209	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR174W	YLR174W	IDP2	hom	Verified	0.276660293111276	0.391020481829228	no	1913	0.37577830614706	1273	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication	glutamate biosynthetic process|isocitrate metabolic process	isocitrate dehydrogenase (NADP+) activity	cytosol
YKR028W	YKR028W	SAP190	hom	Verified	0.276177294158555	0.391205947957498	no	1914	0.390769351490204	1302	NA	FT	CELL CYCLE|RNA PROCESSING|SIGNALING			Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication	TOR signaling cascade|dephosphorylation|G1/S transition of mitotic cell cycle|tRNA wobble uridine modification	molecular_function	cytoplasm
YOR339C	YOR339C	UBC11	hom	Verified	0.275567165572752	0.391440265787164	no	1915	0.382788393599203	1253	NA					Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2	protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YLR361C	YLR361C	DCR2	hom	Verified	0.275055691397347	0.391636726084467	no	1916	0.369800146906877	1242	NA	FT	CELL CYCLE|SIGNALING			Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START	endoplasmic reticulum unfolded protein response|traversing start control point of mitotic cell cycle|protein dephosphorylation	hydrolase activity, acting on ester bonds|phosphoprotein phosphatase activity|phosphoric ester hydrolase activity	cellular_component
YNL297C	YNL297C	MON2	hom	Verified	0.274863518266369	0.391710548082446	no	1917	0.435783218394455	1432	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins	transport|endocytosis|protein targeting to vacuole|Golgi to endosome transport	guanyl-nucleotide exchange factor activity	cytosol|endosome|trans-Golgi network|extrinsic to membrane
YNL231C	YNL231C	PDR16	hom	Verified	0.273925967392677	0.39207075773031	no	1918	0.403522593821014	1326	NA	FF|FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress	response to drug|sterol biosynthetic process|phospholipid biosynthetic process|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cell periphery|lipid particle|plasma membrane|cytoplasm
YDR030C	YDR030C	RAD28	hom	Verified	0.273418535733724	0.392265752989402	no	1919	0.394078553239292	1303	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair	DNA repair	molecular_function	nucleus
YGR100W	YGR100W	MDR1	hom	Verified	0.272920742227607	0.392457070800194	no	1920	0.395248526049387	1324	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM			Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function	intracellular protein transport	Rab GTPase activator activity	cytoplasm
YOR019W	YOR019W	YOR019W	hom	Verified	0.271629932690074	0.392953290772929	no	1921	0.393115256153844	1303	NA	FT	CELL CYCLE			Protein of unknown function that may interact with ribosomes, based on co-purification experiments	mitochondrion degradation	molecular_function	ribosome
YPR077C_d	YPR077C	YPR077C	hom	Dubious	0.27139775223374	0.393042565325328	no	1922	0.39889084212502	1324	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1	Unknown	Unknown	Unknown
YIL067C_p	YIL067C	YIL067C	hom	Uncharacterized	0.270744873364007	0.393293630668342	no	1923	0.397623937351603	1346	NA					Uncharacterized protein of unknown function	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YDR332W	YDR332W	IRC3	hom	Verified	0.270584429857944	0.39335533620626	no	1924	0.390325571207931	1308	NA	FT		MITOCHONDRION		Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	ATP-dependent RNA helicase activity	mitochondrion
YPL196W	YPL196W	OXR1	hom	Verified	0.268893616787505	0.394005774598391	no	1925	0.386294568235849	1296	NA	FT	RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes	cellular response to oxidative stress	molecular_function	mitochondrion
YIL128W	YIL128W	MET18	hom	Verified	0.267875158362403	0.394397707929664	no	1926	0.430472560344293	1927	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE	NUCLEUS		Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19	methionine metabolic process|nucleotide-excision repair|transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YCL057C-A	YCL057C-A	MOS1	hom	Verified	0.267114453722867	0.394690519667581	no	1927	0.368738871042784	1228	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein essential for proper inner membrane organization; conserved component of the mitochondrial inner membrane organizing system (MICOS, MINOS, or MitOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture; ortholog of human MINOS1	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YJR102C	YJR102C	VPS25	hom	Verified	0.266942318361386	0.394756786568387	no	1928	0.418250461938663	1387	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome	negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	structural molecule activity	ESCRT II complex
YMR280C	YMR280C	CAT8	hom	Verified	0.266910180600901	0.394769158970217	no	1929	0.355253475055125	1206	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of glyoxylate cycle by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YHR031C	YHR031C	RRM3	hom	Verified	0.266333207342434	0.394991300302161	no	1930	0.406532990911926	1346	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	NUCLEUS|CHROMOSOME		DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p	mitochondrial genome maintenance|replication fork progression beyond termination site|DNA replication	ATP-dependent DNA helicase activity|DNA helicase activity	nuclear telomeric heterochromatin|replication fork
YLR057W	YLR057W	MNL2	hom	Verified	0.265446524647978	0.395332749844592	no	1931	0.405621623433375	1341	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene	ER-associated protein catabolic process	molecular_function	endoplasmic reticulum
YNR060W	YNR060W	FRE4	hom	Verified	0.264800966527129	0.395581396142602	no	1932	0.391008528870294	1302	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels	siderophore transport	ferric-chelate reductase activity	integral to membrane|plasma membrane
YLR019W	YLR019W	PSR2	hom	Verified	0.264068458499102	0.395863583965536	no	1933	0.398207379706805	1331	NA	FT		PLASMA MEMBRANE		Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p	response to stress	phosphoprotein phosphatase activity	plasma membrane
YDR171W	YDR171W	HSP42	hom	Verified	0.263617382463961	0.396037381466372	no	1934	0.381817339204119	1263	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	cytoskeleton organization	unfolded protein binding	cytoskeleton|chaperonin-containing T-complex|cytoplasm
YLR091W	YLR091W	GEP5	hom	Verified	0.26357710599502	0.396052900808331	no	1935	0.413814813533924	1352	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine	mitochondrial genome maintenance	molecular_function	mitochondrion
YMR313C	YMR313C	TGL3	hom	Verified	0.26296789454259	0.396287662440386	no	1936	0.394958474338754	1325	NA	FT	LIPID METABOLISM|CELL DIVISION			Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation	triglyceride catabolic process|cell budding|cellular lipid metabolic process	triglyceride lipase activity|lysophosphatidylethanolamine acyltransferase activity	lipid particle
YGR021W_p	YGR021W	YGR021W	hom	Uncharacterized	0.262954717528231	0.396292740661967	no	1937	0.402891843624953	1355	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YBR027C_d	YBR027C	YBR027C	hom	Dubious	0.262458765099522	0.396483885996704	no	1938	0.357744591902125	1200	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR141C_p	YBR141C	YBR141C	hom	Uncharacterized	0.261254207562847	0.396948238788179	no	1939	0.379870118692863	1241	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleolus
YNL315C	YNL315C	ATP11	hom	Verified	0.260633744990284	0.397187482047829	no	1940	0.403658969608614	1336	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase	mitochondrion organization|mitochondrial proton-transporting ATP synthase complex assembly	unfolded protein binding	mitochondrion|mitochondrial matrix
YLR381W	YLR381W	CTF3	hom	Verified	0.259918396126646	0.397463360388906	no	1941	0.373909624853328	1243	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6	chromosome segregation|DNA replication initiation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YMR092C	YMR092C	AIP1	hom	Verified	0.259842408728063	0.397492668375919	no	1942	0.395872753870384	1281	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress	actin filament depolymerization|response to osmotic stress	actin binding	nucleus|mating projection tip|cytoplasm|actin cortical patch
YPR149W	YPR149W	NCE102	hom	Verified	0.259641795003639	0.397570046938698	no	1943	0.390145246295926	1294	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)	eisosome assembly|protein secretion|negative regulation of protein phosphorylation|plasma membrane organization|establishment of protein localization to plasma membrane	molecular_function	mitochondrion|integral to membrane|membrane raft|endoplasmic reticulum|cellular bud membrane|plasma membrane|mating projection membrane|cytoplasm
YFR038W	YFR038W	IRC5	hom	Verified	0.259515005774666	0.397618952791894	no	1944	0.377425758480202	1252	NA	FT		NUCLEUS		Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci	mitotic recombination	molecular_function	cellular_component
YML004C	YML004C	GLO1	hom	Verified	0.259203063696928	0.397739283689849	no	1945	0.400443261121374	1316	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress	methylglyoxal catabolic process to D-lactate|glutathione metabolic process	lactoylglutathione lyase activity	nucleus|cytoplasm
YMR003W	YMR003W	AIM34	hom	Verified	0.258427442706398	0.39803851975049	no	1946	0.401665929348027	1307	NA	FT		MITOCHONDRION		Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YPR138C	YPR138C	MEP3	hom	Verified	0.257935180505966	0.398228466575531	no	1947	0.395884848440836	1304	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease	nitrogen utilization|ammonium transport	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YER142C	YER142C	MAG1	hom	Verified	0.257095107861461	0.398552677006817	no	1948	0.382958399286091	1267	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress	base-excision repair, AP site formation|DNA dealkylation involved in DNA repair	alkylbase DNA N-glycosylase activity	nucleus
YPL249C-A	YPL249C-A	RPL36B	hom	Verified	0.25700278524228	0.398588311481493	no	1949	0.35153171329508	1174	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YOR219C	YOR219C	STE13	hom	Verified	0.255603762024963	0.399128406603949	no	1950	0.412133160274561	1372	NA	FT	PROTEOLYSIS	GOLGI APPARATUS		Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor	peptide pheromone maturation	aminopeptidase activity	trans-Golgi network
YKL207W	YKL207W	EMC3	hom	Verified	0.255531258864414	0.399156401836932	no	1951	0.384998073823076	1274	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|integral to membrane
YHL046C	YHL046C	PAU13	hom	Verified	0.255463573107485	0.399182537421379	no	1952	0.388349582272789	1280	NA					Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock	biological_process	molecular_function	cellular_component
YBR041W	YBR041W	FAT1	hom	Verified	0.255151518853558	0.399303037156524	no	1953	0.442226872918023	1466	NA	FT	KETONE METABOLISM|LIPID METABOLISM	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids	very long-chain fatty acid metabolic process|long-chain fatty acid transport	very long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity	intrinsic to internal side of plasma membrane|integral to membrane|endoplasmic reticulum|lipid particle|peroxisome
YJL052W	YJL052W	TDH1	hom	Verified	0.253521947175222	0.399932451807263	no	1954	0.405604552595451	1330	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress	gluconeogenesis|glycolysis	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YLR461W	YLR461W	PAU4	hom	Verified	0.253358808166078	0.399995477855653	no	1955	0.403894858512636	1325	NA					Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YOL006C	YOL006C	TOP1	hom	Verified	0.251846387999054	0.400579900102894	no	1956	0.387316276026981	1257	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination	nuclear migration|chromatin assembly or disassembly|DNA topological change|DNA strand elongation involved in DNA replication|regulation of mitotic recombination|chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|mitotic chromosome condensation|transcription elongation from RNA polymerase II promoter	DNA topoisomerase type I activity	replication fork protection complex|nucleolus|nucleus
YLR110C	YLR110C	CCW12	hom	Verified	0.251748342732777	0.400617793989	no	1957	0.437920646765479	1452	NA	FF|FT	CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH		Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication	conjugation with cellular fusion|agglutination involved in conjugation with cellular fusion|fungal-type cell wall organization	molecular_function	fungal-type cell wall|mating projection tip|cellular bud tip
YIL016W	YIL016W	SNL1	hom	Verified	0.250303231873241	0.401176428665626	no	1958	0.397296997697756	1328	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein	protein folding|nuclear pore organization	ribosome binding	nuclear envelope|mitochondrion|cytosolic ribosome|endoplasmic reticulum membrane|membrane
YIL133C	YIL133C	RPL16A	hom	Verified	0.250237082463591	0.401202004804892	no	1959	0.388823639085514	1314	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YFR013W	YFR013W	IOC3	hom	Verified	0.250218963638716	0.401209010377234	no	1960	0.446169175707794	1461	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication	chromatin remodeling	nucleosome binding|ATPase activity|DNA binding	ISW1 complex
YPR159W	YPR159W	KRE6	hom	Verified	0.249723341149642	0.401400653171915	no	1961	0.419233074581687	1386	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p	fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process	glucosidase activity	integral to endoplasmic reticulum membrane|integral to membrane|site of polarized growth|transport vesicle|plasma membrane
YLR266C	YLR266C	PDR8	hom	Verified	0.249663605473913	0.401423752822163	no	1962	0.387617847420361	1285	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YDR349C	YDR349C	YPS7	hom	Verified	0.249507359763735	0.401484174312544	no	1963	0.415106960415264	1375	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum	fungal-type cell wall organization	aspartic-type endopeptidase activity	endoplasmic reticulum|cytoplasm
YOL122C	YOL122C	SMF1	hom	Verified	0.248069879160877	0.40204017013261	no	1964	0.392676090582261	1294	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins	copper ion transport|cellular copper ion homeostasis|manganese ion transport|cadmium ion transport|cellular manganese ion homeostasis|cellular cadmium ion homeostasis|iron ion transport	solute:hydrogen symporter activity|inorganic cation transmembrane transporter activity	integral to membrane|plasma membrane
YPR037C	YPR037C	ERV2	hom	Verified	0.247897347341846	0.402106916188452	no	1965	0.405618873160326	1336	NA	FT	OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER	protein thiol-disulfide exchange	thiol oxidase activity	integral to endoplasmic reticulum membrane
YMR194W	YMR194W	RPL36A	hom	Verified	0.247613024405657	0.402216916240502	no	1966	0.388911053845763	1290	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YJR024C	YJR024C	MDE1	hom	Verified	0.246157601839603	0.402780117344938	no	1967	0.394122104671915	1289	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant	L-methionine salvage from methylthioadenosine	methylthioribulose 1-phosphate dehydratase activity	cytoplasm
YDL151C_d	YDL151C	BUD30	hom	Dubious	0.245992285914759	0.402844102004862	no	1968	0.41460577712088	1355	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YBL054W	YBL054W	TOD6	hom	Verified	0.245642322050491	0.402979562262095	no	1969	0.387554865512706	1297	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	Rpd3L-Expanded complex|nucleus|Rpd3L complex|cytoplasm
YDR234W	YDR234W	LYS4	hom	Verified	0.24562646680139	0.402985699617649	no	1970	0.415457361793182	1393	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway	lysine biosynthetic process via aminoadipic acid	homoaconitate hydratase activity	mitochondrion
YHR013C	YHR013C	ARD1	hom	Verified	0.244823026250935	0.403296732005442	no	1971	0.405415357478964	1359	NA	FT	CHROMATIN ORGANIZATION		RIBOSOME	Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress	histone acetylation|N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	cytosolic ribosome|NatA complex
YBR148W	YBR148W	YSW1	hom	Verified	0.244771921357003	0.40331651808879	no	1972	0.385934315900151	1298	NA	FT	MEMBRANE ORGANIZATION			Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane	ascospore-type prospore membrane assembly	molecular_function	prospore membrane
YOR035C	YOR035C	SHE4	hom	Verified	0.244442106707456	0.40344421709688	no	1973	0.465546293197946	1547	NA	FF|FT	CYTOSKELETON ORGANIZATION|RNA LOCALIZATION			Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization	mating type switching|intracellular mRNA localization|actin cytoskeleton organization	myosin binding	cytoplasm
YPR140W	YPR140W	TAZ1	hom	Verified	0.244428450028271	0.403449504968812	no	1974	0.406891264415143	1326	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome	cardiolipin acyl-chain remodeling|mitochondrial ATP synthesis coupled electron transport|protein complex assembly|inner mitochondrial membrane organization|cardiolipin metabolic process|phospholipid biosynthetic process	1-acylglycerophosphocholine O-acyltransferase activity	mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YPL140C	YPL140C	MKK2	hom	Verified	0.243758971022821	0.403708749145721	no	1975	0.404049682084167	1330	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION			MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication	signal transduction|peroxisome degradation|protein phosphorylation	MAP kinase kinase activity	intracellular
YOR039W	YOR039W	CKB2	hom	Verified	0.243140218594829	0.403948387957079	no	1976	0.395374346712638	1299	NA	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase	regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase inhibitor activity|protein kinase regulator activity	protein kinase CK2 complex|UTP-C complex|CURI complex
YMR174C	YMR174C	PAI3	hom	Verified	0.24265981039908	0.40413447181098	no	1977	0.398178359160199	1331	NA					Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact	vacuolar protein catabolic process	endopeptidase inhibitor activity	cytoplasm
YDR061W_p	YDR061W	YDR061W	hom	Uncharacterized	0.242108864472256	0.4043479048266	no	1978	0.41293326247536	1357	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance	biological_process	molecular_function	mitochondrion
YGR161C_p	YGR161C	RTS3	hom	Uncharacterized	0.24168071688739	0.404513786193448	no	1979	0.40393474532939	1321	NA	FT		NUCLEUS		Putative component of the protein phosphatase type 2A complex	biological_process	molecular_function	nucleus|cytoplasm
YGL224C	YGL224C	SDT1	hom	Verified	0.241596928714869	0.404546251066133	no	1980	0.405773416733343	1321	NA					Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives	pyrimidine nucleobase metabolic process	nucleotidase activity	cellular_component
YPL225W	YPL225W	YPL225W	hom	Verified	0.240556341126998	0.404949495644985	no	1981	0.40326758783449	1325	NA					Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|cytoplasm
YLR451W	YLR451W	LEU3	hom	Verified	0.240311987961951	0.40504420111379	no	1982	0.405412101485643	1321	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation	negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YNL032W	YNL032W	SIW14	hom	Verified	0.239728115675522	0.405270518620905	no	1983	0.39841703495111	1310	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION			Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm	actin filament organization|endocytosis|protein dephosphorylation|response to stress	protein tyrosine phosphatase activity	cytoplasm
YJL131C	YJL131C	AIM23	hom	Verified	0.239525123166068	0.405349208935932	no	1984	0.399545972183242	1296	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss	positive regulation of mitochondrial translational initiation	ribosome binding|translation initiation factor activity	mitochondrion
YHR116W	YHR116W	COX23	hom	Verified	0.237915308575306	0.405973390930974	no	1985	0.409990187347655	1346	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex assembly	molecular_function	mitochondrion|cytoplasm
YGR229C	YGR229C	SMI1	hom	Verified	0.237877015400264	0.405988241465472	no	1986	0.441020111138862	1452	NA	FF|FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	NUCLEUS|SITE OF POLARIZED GROWTH		Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity	regulation of mitotic cell cycle|regulation of fungal-type cell wall biogenesis	molecular_function	incipient cellular bud site|cellular bud neck|mating projection tip
YLR065C	YLR065C	ENV10	hom	Verified	0.237067958943231	0.406302034471105	no	1987	0.408035512287915	1355	NA	FF|FT	VACUOLAR PROTEIN PROCESSING			Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene	vacuolar protein processing	molecular_function	integral to membrane
YPR116W	YPR116W	RRG8	hom	Verified	0.236622366988601	0.406474883280228	no	1988	0.396326381586694	1298	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport	mitochondrial genome maintenance	molecular_function	mitochondrion
YJR075W	YJR075W	HOC1	hom	Verified	0.236573215322573	0.406493950735173	no	1989	0.403350193884861	1357	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele	cell wall mannoprotein biosynthetic process|substituted mannan metabolic process	alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups	alpha-1,6-mannosyltransferase complex
YMR137C	YMR137C	PSO2	hom	Verified	0.236367181825595	0.406573879927751	no	1990	0.398052602657275	1315	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress	DNA repair|double-strand break repair	damaged DNA binding|5'-3' exonuclease activity	nucleus
YJL121C	YJL121C	RPE1	hom	Verified	0.236236848353667	0.406624443857924	no	1991	0.422446809305645	1410	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress	pentose-phosphate shunt	ribulose-phosphate 3-epimerase activity	cytosol
YDL034W_d	YDL034W	YDL034W	hom	Dubious	0.235450265194641	0.406929638212185	no	1992	0.403580141609826	1347	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene	Unknown	Unknown	Unknown
YDR097C	YDR097C	MSH6	hom	Verified	0.235303273487558	0.406986677285227	no	1993	0.395878352302089	1306	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p	mismatch repair|meiotic mismatch repair	guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity|single base insertion or deletion binding|ATP binding	MutSalpha complex|nucleus
YDR483W	YDR483W	KRE2	hom	Verified	0.234848895718518	0.407163007775234	no	1994	0.435164480141518	1435	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication	N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YGL260W_p	YGL260W	YGL260W	hom	Uncharacterized	0.234740468993598	0.407205087742619	no	1995	0.40414982776006	1361	NA					Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium	biological_process	molecular_function	cellular_component
YLR394W	YLR394W	CST9	hom	Verified	0.233789638934786	0.407574146816357	no	1996	0.414231956198135	1369	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate	synaptonemal complex assembly|protein sumoylation|synapsis|reciprocal meiotic recombination	SUMO ligase activity	condensed nuclear chromosome|nuclear chromosome
YOL060C	YOL060C	MAM3	hom	Verified	0.233643930237619	0.407630710044916	no	1997	0.398801445071196	1334	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS			Protein required for normal mitochondrial morphology, has similarity to hemolysins	cellular manganese ion homeostasis|mitochondrion organization	molecular_function	fungal-type vacuole membrane|integral to membrane
YFL025C	YFL025C	BST1	hom	Verified	0.233224347040699	0.407793600438328	no	1998	0.464905481219136	1544	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules	protein retention in ER lumen|vesicle organization|ER-associated protein catabolic process|ER to Golgi vesicle-mediated transport|GPI anchor metabolic process	phosphatidylinositol deacylase activity	integral to membrane|endoplasmic reticulum
YJL199C_d	YJL199C	MBB1	hom	Dubious	0.232247101769011	0.408173047896354	no	1999	0.408861182968862	1337	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies	Unknown	Unknown	Unknown
YPR045C	YPR045C	THP3	hom	Verified	0.231099691890218	0.408618677238619	no	2000	0.388043174320156	1313	NA	FT	RNA PROCESSING	NUCLEUS|CHROMOSOME		Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes	mRNA splicing, via spliceosome	molecular_function	nucleus|transcriptionally active chromatin
YIR038C	YIR038C	GTT1	hom	Verified	0.230598480022868	0.408813374278205	no	2001	0.400727326712257	1330	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p	glutathione metabolic process	glutathione transferase activity|glutathione peroxidase activity	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum|plasma membrane
YDR389W	YDR389W	SAC7	hom	Verified	0.229880193311513	0.40909243382241	no	2002	0.461503639076344	1507	NA	FF|FT	CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION	CYTOSKELETON		GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate	actin filament reorganization involved in cell cycle|small GTPase mediated signal transduction	Rho GTPase activator activity	intracellular
YDL233W_p	YDL233W	MFG1	hom	Uncharacterized	0.229579488326599	0.409209273559915	no	2003	0.40732121122977	1344	NA	FT		NUCLEUS		Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YPL127C	YPL127C	HHO1	hom	Verified	0.229544458967943	0.409222884836986	no	2004	0.406935007812106	1362	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination	negative regulation of DNA recombination|negative regulation of chromatin silencing|regulation of transcription, DNA-dependent	DNA binding	nucleus|nuclear nucleosome
YLR398C	YLR398C	SKI2	hom	Verified	0.229500250378983	0.409240063022617	no	2005	0.409399411996019	1374	NA	FT	TRANSLATION			Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay	RNA helicase activity	Ski complex
YBL046W	YBL046W	PSY4	hom	Verified	0.229153595378212	0.40937476922046	no	2006	0.406968653340483	1351	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2	Unknown|protein dephosphorylation	protein phosphatase regulator activity	nucleus|cytoplasm
YIL159W	YIL159W	BNR1	hom	Verified	0.228865783436789	0.40948661780471	no	2007	0.405780479432535	1357	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1	barbed-end actin filament capping|actin filament bundle assembly|formin-nucleated actin cable assembly	profilin binding	cellular bud neck
YMR010W_p	YMR010W	YMR010W	hom	Uncharacterized	0.228708854973802	0.409547605961776	no	2008	0.410135106509067	1322	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1	biological_process	molecular_function	integral to membrane|cytoplasm
YLR460C_p	YLR460C	YLR460C	hom	Uncharacterized	0.228012894424925	0.409818108120621	no	2009	0.381693463957537	1254	NA	FT	OXIDATION-REDUCTION PROCESS			Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine	biological_process	molecular_function	cellular_component
YIR009W	YIR009W	MSL1	hom	Verified	0.227817614181277	0.409894016301039	no	2010	0.423432506782465	1398	NA	FT	RNA PROCESSING	NUCLEUS		U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members	mRNA splicing, via spliceosome	U2 snRNA binding	U2 snRNP|U2-type prespliceosome
YNL117W	YNL117W	MLS1	hom	Verified	0.227576837328327	0.409987614302785	no	2011	0.41731171594561	1386	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic	glyoxylate cycle	malate synthase activity	peroxisomal matrix|cytoplasm
YOR228C	YOR228C	YOR228C	hom	Verified	0.227134212189324	0.410159690849389	no	2012	0.419200965606175	1374	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to membrane
YGR014W	YGR014W	MSB2	hom	Verified	0.226622582827151	0.410358615281349	no	2013	0.42086301568485	1409	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate	signal transduction involved in filamentous growth|osmosensory signaling pathway via Sho1 osmosensor|establishment of cell polarity|hyperosmotic response|response to osmotic stress	osmosensor activity	site of polarized growth|integral to plasma membrane
YLR184W_d	YLR184W	YLR184W	hom	Dubious	0.226150555609011	0.410542162630568	no	2014	0.381402721623125	1269	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL151W	YOL151W	GRE2	hom	Verified	0.226100815179706	0.410561505292577	no	2015	0.393717380118502	1318	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress	ergosterol metabolic process|filamentous growth	methylglyoxal reductase (NADPH-dependent) activity|3-methylbutanol:NAD(P) oxidoreductase activity	nucleus|cytoplasm
YDR149C_d	YDR149C	YDR149C	hom	Dubious	0.225970854684233	0.410612044321619	no	2016	0.410299747154469	1367	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth	Unknown	Unknown	Unknown
YOR348C	YOR348C	PUT4	hom	Verified	0.224222498724492	0.411292088838978	no	2017	0.417516949436545	1398	NA	FT		PLASMA MEMBRANE		Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells	neutral amino acid transport|proline transport|gamma-aminobutyric acid transport	neutral amino acid transmembrane transporter activity|L-proline transmembrane transporter activity	integral to membrane|plasma membrane
YGL156W	YGL156W	AMS1	hom	Verified	0.223928723043094	0.411406382717298	no	2018	0.414907597181943	1390	NA	FT	CARBOHYDRATE METABOLISM			Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway	oligosaccharide catabolic process|cellular carbohydrate metabolic process	alpha-mannosidase activity	fungal-type vacuole membrane
YDR420W	YDR420W	HKR1	hom	Verified	0.223868261409188	0.411429906341768	no	2019	0.414667395613085	1383	NA	FT	CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection	(1->3)-beta-D-glucan biosynthetic process|fungal-type cell wall organization|osmosensory signaling pathway via Sho1 osmosensor|hyperosmotic response|cellular bud site selection	osmosensor activity	site of polarized growth|plasma membrane
YKL123W_d	YKL123W	YKL123W	hom	Dubious	0.223707615478492	0.411492409913328	no	2020	0.416106675719745	1394	NA					Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4	Unknown	Unknown	Unknown
YPR006C	YPR006C	ICL2	hom	Verified	0.223236970662366	0.411675539720242	no	2021	0.41515604837785	1374	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol	threonine catabolic process|propionate metabolic process	methylisocitrate lyase activity	mitochondrion|mitochondrial matrix
YKR089C	YKR089C	TGL4	hom	Verified	0.222713414939676	0.411879279981784	no	2022	0.406812931861633	1325	NA	FT	LIPID METABOLISM|CELL DIVISION			Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p	phospholipid metabolic process|triglyceride catabolic process|triglyceride mobilization|cell budding	lysophosphatidic acid acyltransferase activity|triglyceride lipase activity|calcium-independent phospholipase A2 activity|sterol esterase activity	lipid particle
YJL175W_d	YJL175W	YJL175W	hom	Dubious	0.221960700169344	0.412172238471529	no	2023	0.410240970108551	1353	NA					Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor	Unknown	Unknown	Unknown
YGL033W	YGL033W	HOP2	hom	Verified	0.220771575287776	0.412635148563411	no	2024	0.425096818133785	1405	NA	FF|FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair	synapsis|reciprocal meiotic recombination	protein binding|double-stranded DNA binding	condensed nuclear chromosome
YBR187W_p	YBR187W	GDT1	hom	Uncharacterized	0.220483895798136	0.412747156546003	no	2025	0.41126114229479	1357	NA					Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YFL042C_p	YFL042C	YFL042C	hom	Uncharacterized	0.220195930837592	0.412859282791986	no	2026	0.417013560223765	1376	NA					Putative protein of unknown function; YFL042C is not an essential gene	biological_process	molecular_function	cellular_component
YNL086W_p	YNL086W	SNN1	hom	Uncharacterized	0.219988610766737	0.412940012367585	no	2027	0.405369645853574	1321	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes	biological_process	molecular_function	endosome|BLOC-1 complex
YNL047C	YNL047C	SLM2	hom	Verified	0.219409328862505	0.413165601844833	no	2028	0.392211063235152	1296	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol binding	plasma membrane
YKR075C_p	YKR075C	YKR075C	hom	Uncharacterized	0.219157835658868	0.413263549654797	no	2029	0.4109037235191	1354	NA	FT		NUCLEUS		Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YJL118W	YJL118W	YJL118W	hom	Verified	0.215866185312294	0.414546027936338	no	2030	0.405036439037431	1335	NA					Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein	biological_process	molecular_function	ribosome
YBR130C	YBR130C	SHE3	hom	Verified	0.215557178527578	0.414666468806905	no	2031	0.418226927057732	1384	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance	mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization	mRNA binding	actin cap|cytoplasm|cellular bud tip
YLR431C	YLR431C	ATG23	hom	Verified	0.215309249469729	0.414763109352295	no	2032	0.422567701029144	1393	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p	protein localization to pre-autophagosomal structure|positive regulation of macroautophagy|CVT pathway	molecular_function	pre-autophagosomal structure|extrinsic to membrane
YHL036W	YHL036W	MUP3	hom	Verified	0.215205521785257	0.41480354301373	no	2033	0.426146764982643	1409	NA					Low affinity methionine permease, similar to Mup1p	amino acid transport	L-methionine transmembrane transporter activity	integral to membrane|membrane
YCL042W_p	YCL042W	YCL042W	hom	Uncharacterized	0.21505108478419	0.414863745137214	no	2034	0.424930260674767	1434	NA					Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YLR325C	YLR325C	RPL38	hom	Verified	0.212963340765934	0.415677778291137	no	2035	0.421939599296698	1381	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YNL191W	YNL191W	DUG3	hom	Verified	0.212784947984146	0.415747352332117	no	2036	0.411590574636069	1365	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	peptidase activity|omega peptidase activity|gamma-glutamyltransferase activity|carbon-nitrogen ligase activity, with glutamine as amido-N-donor	cytoplasm
YOL124C	YOL124C	TRM11	hom	Verified	0.211328339432126	0.416315535289704	no	2037	0.423662727079851	1383	NA	FT	RNA PROCESSING			Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain	tRNA methylation	S-adenosylmethionine-dependent methyltransferase activity|RNA binding|tRNA (guanine-N2-)-methyltransferase activity	cytoplasm|tRNA (m2G10) methyltransferase complex
YNR061C	YNR061C	YNR061C	hom	Verified	0.210700547793751	0.416560473561951	no	2038	0.405359928539671	1346	NA					Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YBL048W_d	YBL048W	RRT1	hom	Dubious	0.210598912593598	0.41660013045361	no	2039	0.425675439816787	1415	NA					Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YBL021C	YBL021C	HAP3	hom	Verified	0.209889548126465	0.416876939963867	no	2040	0.426251846154477	1417	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex
YGL127C	YGL127C	SOH1	hom	Verified	0.209334477550826	0.417093569378188	no	2041	0.423960038273243	1416	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits	DNA repair|meiotic gene conversion|meiotic sister chromatid segregation|transcription from RNA polymerase II promoter	molecular_function	core mediator complex|nucleus
YML014W	YML014W	TRM9	hom	Verified	0.208454570906894	0.417437025302601	no	2042	0.387157961925992	1285	NA	FT	RNA PROCESSING	NUCLEUS		tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses	chronological cell aging|tRNA methylation|tRNA wobble uridine modification|response to stress	tRNA (uracil) methyltransferase activity	nucleus|cytoplasm
YGR161W-C_p	YGR161W-C	YGR161W-C	hom	Uncharacterized	0.208211027729655	0.417532099197744	no	2043	0.402428810232949	1354	NA					Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	cellular_component
YPL165C	YPL165C	SET6	hom	Verified	0.206962996796762	0.418019378539395	no	2044	0.411483864046281	1335	NA					SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability	biological_process	molecular_function	cellular_component
YDR507C	YDR507C	GIN4	hom	Verified	0.206285854685217	0.418283813621894	no	2045	0.439400900451198	1472	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication	protein autophosphorylation|budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly	protein kinase activity	cellular bud neck
YOR215C	YOR215C	AIM41	hom	Verified	0.206239732047754	0.418301826612132	no	2046	0.420423665350623	1387	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YPL033C	YPL033C	SRL4	hom	Verified	0.206181188750605	0.418324690682351	no	2047	0.430917509183781	1434	NA	FT	NUCLEOTIDE METABOLISM			Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p	deoxyribonucleoside triphosphate metabolic process	molecular_function	cellular_component
YBR015C	YBR015C	MNN2	hom	Verified	0.203104012808365	0.419526867666007	no	2048	0.494516531031321	1695	NA	FF|FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment	protein glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YLR390W-A	YLR390W-A	CCW14	hom	Verified	0.20233159611058	0.419828750313444	no	2049	0.419369749000761	1359	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall	fungal-type cell wall organization	structural constituent of cell wall	mitochondrion|fungal-type cell wall
YBR071W	YBR071W	YBR071W	hom	Verified	0.201243284139	0.420254173947662	no	2050	0.42544231118783	1399	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking	biological_process	molecular_function	cellular bud neck|cytoplasm
YHR205W	YHR205W	SCH9	hom	Verified	0.201048242986265	0.420330425839955	no	2051	0.401881340881463	1316	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|CHROMOSOME		AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan	protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|regulation of protein localization|positive regulation of transcription from RNA polymerase III promoter|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase I promoter|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of cell size|regulation of response to osmotic stress	protein serine/threonine kinase activity	chromatin|fungal-type vacuole membrane|nucleus|cytoplasm
YDL049C	YDL049C	KNH1	hom	Verified	0.20045483794622	0.420562437600768	no	2052	0.411253615635737	1352	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance	(1->6)-beta-D-glucan biosynthetic process	molecular_function	fungal-type cell wall|extracellular region
YNR018W	YNR018W	RCF2	hom	Verified	0.200189186328481	0.420666312029367	no	2053	0.421381469701134	1374	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion|mitochondrial respiratory chain supercomplex|mitochondrial respiratory chain complex IV|integral to mitochondrial inner membrane
YPR108W-A_p	YPR108W-A	YPR108W-A	hom	Uncharacterized	0.200095664573694	0.420702881986207	no	2054	0.425566816313665	1400	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YOR029W_d	YOR029W	YOR029W	hom	Dubious	0.199810013958372	0.420814584625461	no	2055	0.384691675976445	1270	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR086W	YCR086W	CSM1	hom	Verified	0.199567347495841	0.420909483476468	no	2056	0.385416536850116	1300	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME	KINETOCHORE	Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation	meiotic chromosome segregation|rDNA condensation|protein localization to nucleolar rDNA repeats|homologous chromosome segregation	molecular_function	nuclear envelope|nucleolus|monopolin complex
YKL075C_p	YKL075C	YKL075C	hom	Uncharacterized	0.199096358633242	0.421093684800452	no	2057	0.427005296393015	1420	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin	response to drug	molecular_function	cytoplasm
YLR109W	YLR109W	AHP1	hom	Verified	0.19846796026985	0.421339475062633	no	2058	0.424003672671756	1394	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p	cellular response to oxidative stress|response to metal ion|cell redox homeostasis	thioredoxin peroxidase activity	plasma membrane|cytoplasm
YDR134C	YDR134C	YDR134C	hom	pseudogene	0.198308298702069	0.421401929601533	no	2059	0.417651574284984	1381	NA					Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication	biological_process	molecular_function	fungal-type cell wall
YOR051C	YOR051C	ETT1	hom	Verified	0.198297212751161	0.421406266147183	no	2060	0.396019810522964	1293	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	NUCLEUS		Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough	translational termination	molecular_function	nucleus
YMR098C	YMR098C	ATP25	hom	Verified	0.19752369437494	0.421708870624074	no	2061	0.429269194226893	1416	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene	mRNA stabilization|mitochondrial proton-transporting ATP synthase complex assembly	molecular_function	mitochondrion|mitochondrial inner membrane
YDR226W	YDR226W	ADK1	hom	Verified	0.196874357304626	0.421962930424139	no	2062	0.417602032212988	1400	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress	ADP biosynthetic process|DNA replication initiation|nucleotide metabolic process	adenylate kinase activity	mitochondrion|mitochondrial intermembrane space|cytoplasm
YKL113C	YKL113C	RAD27	hom	Verified	0.196286355524019	0.422193020188087	no	2063	0.432493970059963	1434	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family	double-strand break repair via nonhomologous end joining|replicative cell aging|DNA replication, removal of RNA primer|base-excision repair, base-free sugar-phosphate removal|gene conversion at mating-type locus, DNA repair synthesis	5'-3' exonuclease activity|5'-flap endonuclease activity	mitochondrion|nucleus
YOR185C	YOR185C	GSP2	hom	Verified	0.196244601367603	0.422209359931706	no	2064	0.439681638977774	1448	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM	NUCLEUS		GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress	nucleus organization	GTPase activity	integral to membrane|nucleus
YNL335W_p	YNL335W	DDI3	hom	Uncharacterized	0.196194008973168	0.42222915854137	no	2065	0.422447098083584	1413	NA					Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants	biological_process	molecular_function	cellular_component
YOL072W	YOL072W	THP1	hom	Verified	0.196125577843892	0.422255938397335	no	2066	0.456742401993467	1512	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding	mRNA export from nucleus|mRNA 3'-end processing|transcription-coupled nucleotide-excision repair|cellular bud site selection|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|transcription elongation from RNA polymerase II promoter	double-stranded DNA binding|RNA binding	nuclear envelope|nucleus|transcription export complex 2|nuclear pore
YPR192W	YPR192W	AQY1	hom	Verified	0.195390485834696	0.422543632138498	no	2067	0.408935546945072	1365	NA	FT		PLASMA MEMBRANE		Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance	ascospore formation|water transport	water channel activity	integral to membrane|plasma membrane
YBL044W_p	YBL044W	YBL044W	hom	Uncharacterized	0.193728804453	0.423194118204717	no	2068	0.411720520029225	1358	NA					Putative protein of unknown function; YBL044W is not an essential protein	biological_process	molecular_function	cellular_component
YNL025C	YNL025C	SSN8	hom	Verified	0.193259439530682	0.423377895012877	no	2069	0.425878453261549	1381	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance	positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter	cyclin-dependent protein kinase regulator activity	mediator complex
YBR008C	YBR008C	FLR1	hom	Verified	0.193048606048169	0.423460450931585	no	2070	0.410030356031621	1331	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress	drug transmembrane transport|transmembrane transport	fluconazole transporter activity|drug transmembrane transporter activity	integral to membrane|plasma membrane
YNL195C_p	YNL195C	YNL195C	hom	Uncharacterized	0.191149620422711	0.424204186407645	no	2071	0.431976794118976	1425	NA	FT		MITOCHONDRION		Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YAL029C	YAL029C	MYO4	hom	Verified	0.190428878862119	0.424486534817504	no	2072	0.421179819294629	1394	NA	FT	RNA LOCALIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH|CYTOSKELETON		Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication	mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization	microfilament motor activity|actin filament binding	mitochondrion|filamentous actin|myosin V complex|cellular bud|cellular bud tip
YLR206W	YLR206W	ENT2	hom	Verified	0.189968551932939	0.424666886842471	no	2073	0.398207796287438	1322	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus	actin filament organization|endocytosis|actin cortical patch assembly	clathrin binding	mating projection tip|actin cortical patch
YDR220C_d	YDR220C	YDR220C	hom	Dubious	0.189642372133089	0.424794690756595	no	2074	0.417543509858993	1391	NA					Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein	Unknown	Unknown	Unknown
YGL041C-B_p	YGL041C-B	YGL041C-B	hom	Uncharacterized	0.189532286914453	0.424837826180905	no	2075	0.421844820228711	1384	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YHR142W	YHR142W	CHS7	hom	Verified	0.188931727497586	0.425073163211233	no	2076	0.427178610560502	1964	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress	protein folding|ER to Golgi vesicle-mediated transport|fungal-type cell wall chitin biosynthetic process	unfolded protein binding	integral to membrane|endoplasmic reticulum membrane
YLR455W	YLR455W	YLR455W	hom	Verified	0.187558293558016	0.425611461424825	no	2077	0.432285030515467	1428	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YOR184W	YOR184W	SER1	hom	Verified	0.187011769138754	0.425825702650492	no	2078	0.430772189924672	1431	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress	serine family amino acid biosynthetic process|L-serine biosynthetic process|purine nucleobase biosynthetic process	O-phospho-L-serine:2-oxoglutarate aminotransferase activity	cytoplasm
YMR278W	YMR278W	PGM3	hom	Verified	0.186270401449334	0.426116358728761	no	2079	0.410563586916447	1362	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential	biological_process	phosphoglucomutase activity	nucleus|cytoplasm
YGR187C	YGR187C	HGH1	hom	Verified	0.185898598495096	0.426262140642244	no	2080	0.433965735328078	1412	NA					Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	cytoplasm
YJR005C-A_p	YJR005C-A	YJR005C-A	hom	Uncharacterized	0.185302209083214	0.426496002719206	no	2081	0.421534206100955	1381	NA					Putative protein of unknown function; originally identified as a syntenic homolog of an <i>Ashbya gossypii</i> gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YBR076W	YBR076W	ECM8	hom	Verified	0.185279619108002	0.426504861430825	no	2082	0.437010895400028	1441	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function	fungal-type cell wall organization	molecular_function	cellular_component
YPR051W	YPR051W	MAK3	hom	Verified	0.185136983836521	0.426560797042152	no	2083	0.445399882804859	1481	NA	FT		NUCLEUS		Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex
YAL020C	YAL020C	ATS1	hom	Verified	0.185021699225658	0.426606007943269	no	2084	0.43008645993891	1429	NA	FT	RNA PROCESSING|CELL DIVISION|CYTOSKELETON ORGANIZATION			Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle	microtubule-based process|budding cell bud growth|microtubule cytoskeleton organization|tRNA wobble uridine modification	molecular_function	cytoplasm
YIL164C	YIL164C	NIT1	hom	Verified	0.184901571794534	0.42665311906806	no	2085	0.407867230272331	1351	NA					Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene	biological_process	nitrilase activity	cellular_component
YOL082W	YOL082W	ATG19	hom	Verified	0.184286212834619	0.426894464629458	no	2086	0.410510718261208	1350	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles	vesicle organization|ER-associated protein catabolic process|protein processing|protein complex localization|CVT pathway	protein binding, bridging	pre-autophagosomal structure|cytoplasm|CVT complex|extrinsic to membrane
YKR088C	YKR088C	TVP38	hom	Verified	0.183422724846573	0.427233173242984	no	2087	0.423934168888989	1407	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	vesicle-mediated transport|mitotic spindle elongation	molecular_function	integral to membrane|integral to Golgi membrane|cytoplasm
YGR010W	YGR010W	NMA2	hom	Verified	0.18332059534827	0.427273237736065	no	2088	0.434476969694742	1419	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication	NAD biosynthetic process	nicotinamide-nucleotide adenylyltransferase activity	nucleus
YNR073C_p	YNR073C	YNR073C	hom	Uncharacterized	0.181542371423396	0.42797093903069	no	2089	0.46473079441905	1551	NA					Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p	biological_process	mannitol dehydrogenase activity	cellular_component
YDR029W_d	YDR029W	YDR029W	hom	Dubious	0.181140107316018	0.42812880209792	no	2090	0.425966690091678	1390	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR023C	YBR023C	CHS3	hom	Verified	0.180783512730555	0.428268752402857	no	2091	0.454689829495323	1519	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH		Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan	ascospore wall assembly|fungal-type cell wall chitin biosynthetic process|cytokinesis	chitin synthase activity	incipient cellular bud site|integral to membrane|chitosome|prospore membrane|cellular bud neck|mating projection tip|cytoplasm
YDR247W	YDR247W	VHS1	hom	Verified	0.180682368188049	0.428308449571891	no	2092	0.434029900078522	1412	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION			Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p	protein phosphorylation|G1/S transition of mitotic cell cycle	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YPL206C	YPL206C	PGC1	hom	Verified	0.180053255987795	0.428555379547431	no	2093	0.392915892152295	1305	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs	glycerophospholipid catabolic process|phosphatidylglycerol catabolic process	phosphatidylglycerol phospholipase C activity	mitochondrion|lipid particle
YGL227W	YGL227W	VID30	hom	Verified	0.179393456694873	0.428814384425037	no	2094	0.430662939718419	1413	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and