strainid	orf	gene	zyg	qualifier	SGTC_1452|4194-0072.score	SGTC_1452|4194-0072.expt.zyg.pval	SGTC_1452|4194-0072.expt.zyg.significant	SGTC_1452|4194-0072.expt.zyg.rank	strain.pval	strain.rank	clearance	Fclass	Fterms.BP	Fterms.CC	Fterms.complex	description	GO_process	GO_function	GO_component
YPR108W-A_p	YPR108W-A	YPR108W-A	hom	Uncharacterized	5.65479131721995	7.8017868148548e-09	yes	1	2.90796914168943e-08	3	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YJL047C	YJL047C	RTT101	hom	Verified	5.50650154072539	1.83017380847068e-08	yes	2	2.34173856101572e-07	15	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p	replication fork processing|negative regulation of transposition, RNA-mediated|regulation of mitosis|nonfunctional rRNA decay|ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	Cul8-RING ubiquitin ligase complex|nucleus|cytoplasm
YDR123C	YDR123C	INO2	hom	Verified	4.79433259036656	8.16086486051839e-07	yes	3	2.13529975046414e-06	12	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion	phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDL047W	YDL047W	SIT4	hom	Verified	4.77695123597084	8.89864553361456e-07	yes	4	8.90458190049956e-07	8	NA	FT	CELL CYCLE|RNA PROCESSING|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization	intracellular protein kinase cascade|replicative cell aging|G1/S transition of mitotic cell cycle|actin cytoskeleton organization|DNA repair|cellular response to oxidative stress|fungal-type cell wall organization|TOR signaling cascade|dephosphorylation|tRNA wobble uridine modification	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YER158C_p	YER158C	YER158C	hom	Uncharacterized	4.3936806700174	5.57237430706946e-06	yes	5	9.94561777755203e-08	5	NA					Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YNR041C	YNR041C	COQ2	hom	Verified	4.16777358953014	1.53794611831174e-05	yes	6	1.28985028320661e-05	24	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis	ubiquinone biosynthetic process	4-hydroxybenzoate octaprenyltransferase activity	mitochondrion|integral to mitochondrial membrane|integral to membrane
YNL147W	YNL147W	LSM7	hom	Verified	4.15617129796616	1.61812609317182e-05	yes	7	3.87507621925107e-05	33	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasm
YDR184C	YDR184C	ATC1	hom	Verified	4.14854751046122	1.67295706693469e-05	yes	8	7.58268021193585e-05	20	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS		Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress	bipolar cellular bud site selection|response to stress	molecular_function	nucleus
YDL072C	YDL072C	YET3	hom	Verified	4.12248115872989	1.87406638201574e-05	yes	9	1.31378030994492e-05	12	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YFR010W	YFR010W	UBP6	hom	Verified	4.10582343550779	2.01438567082761e-05	yes	10	0.00037172596734306	26	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance	protein deubiquitination	ubiquitin-specific protease activity	proteasome complex|proteasome regulatory particle
YDL177C_p	YDL177C	YDL177C	hom	Uncharacterized	3.99770471068516	3.19798351039536e-05	yes	11	5.21487911318793e-06	7	NA					Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene	biological_process	molecular_function	cellular_component
YGL170C	YGL170C	SPO74	hom	Verified	3.96810237031903	3.62236070507606e-05	yes	12	4.65516237963755e-05	11	NA	FT		NUCLEUS|CYTOSKELETON		Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation	ascospore formation	structural molecule activity	spindle pole body
YBR058C-A	YBR058C-A	TSC3	hom	Verified	3.96403365150941	3.68469286600257e-05	yes	13	0.0146409003702934	413	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis	3-keto-sphinganine metabolic process|sphingolipid biosynthetic process	enzyme activator activity	SPOTS complex
YNL054W	YNL054W	VAC7	hom	Verified	3.94403438688129	4.00610808202105e-05	yes	14	2.33398089742731e-05	19	NA	FT	LIPID METABOLISM			Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock	positive regulation of phosphatidylinositol biosynthetic process|positive regulation of kinase activity	molecular_function	fungal-type vacuole membrane|integral to membrane|PAS complex|vacuolar membrane|cytoplasm
YGL013C	YGL013C	PDR1	hom	Verified	3.82524036698631	6.53222777973635e-05	yes	15	0.00537694201935943	228	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RSC COMPLEX	Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication	Unknown|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YGL009C	YGL009C	LEU1	hom	Verified	3.68640860744473	0.000113720534263076	yes	16	9.71626634227028e-05	8	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway	leucine biosynthetic process	3-isopropylmalate dehydratase activity	cytosol
YGL230C_p	YGL230C	YGL230C	hom	Uncharacterized	3.68542352514654	0.000114161317760752	yes	17	2.16745269101363e-05	5	NA					Putative protein of unknown function; non-essential gene	biological_process	molecular_function	cellular_component
YKL055C	YKL055C	OAR1	hom	Verified	3.68151798841006	0.000115924713853078	yes	18	0.000479619497843227	51	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p	fatty acid metabolic process|aerobic respiration	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	mitochondrion
YMR205C	YMR205C	PFK2	hom	Verified	3.68098618339525	0.000116166797990819	yes	19	0.000446159185567163	18	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes	proton transport|glycolysis	mRNA binding|6-phosphofructokinase activity	mitochondrion|6-phosphofructokinase complex|cytoplasm
YEL047C	YEL047C	FRD1	hom	Verified	3.67768994624321	0.000117677900744926	yes	20	9.48242164410841e-05	15	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication	cellular response to anoxia	fumarate reductase (NADH) activity	cytosol|mitochondrion|ribosome|plasma membrane
YNL089C_d	YNL089C	YNL089C	hom	Dubious	3.60767785360656	0.000154474876119735	yes	21	0.000107321258564041	16	NA					Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins	Unknown	Unknown	Unknown
YDR216W	YDR216W	ADR1	hom	Verified	3.51652337025905	0.000218619082533072	yes	22	0.000292391827963831	21	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING|PEROXISOME ORGANIZATION	NUCLEUS		Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization	negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|chromatin organization|regulation of transcription by chromatin organization|positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|peroxisome organization|positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|TFIIB-class transcription factor binding|sequence-specific DNA binding|TFIID-class transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	nucleus
YJR061W_p	YJR061W	YJR061W	hom	Uncharacterized	3.51403768656342	0.000220675095847832	yes	23	0.00021380489865172	16	NA					Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YNR013C	YNR013C	PHO91	hom	Verified	3.51334791796012	0.000221248823379535	yes	24	0.000357913558773778	16	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth	phosphate ion transport|polyphosphate metabolic process	phosphate ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|membrane
YLR113W	YLR113W	HOG1	hom	Verified	3.50514849055607	0.000228176339223847	yes	25	0.000584797978281723	12	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase II promoter by pheromones|protein phosphorylation|hyperosmotic response|response to arsenic-containing substance|osmosensory signaling pathway|positive regulation of transcription from RNA polymerase II promoter|cellular response to heat	MAP kinase activity	nucleus|cytoplasm
YHR076W	YHR076W	PTC7	hom	Verified	3.44509915518417	0.000285424972751864	yes	26	0.00071796588446856	31	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope	biological_process	protein serine/threonine phosphatase activity	nuclear envelope|mitochondrion
YJL022W_d	YJL022W	YJL022W	hom	Dubious	3.43416347180552	0.00029719280908223	yes	27	0.000415554859295619	20	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130	Unknown	Unknown	Unknown
YGR045C_d	YGR045C	YGR045C	hom	Dubious	3.39891031195187	0.000338274490360625	yes	28	0.000118086419107118	13	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL164C	YKL164C	PIR1	hom	Verified	3.39860283412717	0.000338654975315383	yes	29	0.000248753556438014	11	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS			O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication	intracellular protein transport|fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall
YDR174W	YDR174W	HMO1	hom	Verified	3.37347645928473	0.000371126964847258	yes	30	0.000542303288357943	58	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase	regulation of transcription from RNA polymerase I promoter|regulation of transcription by chromatin organization|regulation of ribosomal protein gene transcription from RNA polymerase II promoter	double-stranded DNA binding|four-way junction DNA binding|DNA binding, bending	nuclear chromatin|nucleolus|cytoplasm
YOL137W	YOL137W	BSC6	hom	Verified	3.36561343609661	0.000381868285025422	yes	31	0.000425719410152634	22	NA	FT		GOLGI APPARATUS		Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression	biological_process	molecular_function	COPI-coated vesicle|integral to membrane|clathrin-coated vesicle
YGL002W	YGL002W	ERP6	hom	Verified	3.32150672186346	0.000447664128768254	yes	32	0.00048191999658233	19	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport	molecular_function	mitochondrion|integral to membrane
YMR116C	YMR116C	ASC1	hom	Verified	3.30639524825811	0.000472523392119463	yes	33	0.000651397221947871	52	NA	FT	SIGNALING|TRANSLATION		RIBOSOME	G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation	negative regulation of translation|glucose mediated signaling pathway|G-protein coupled receptor signaling pathway|invasive growth in response to glucose limitation	G-protein alpha-subunit binding|GDP-dissociation inhibitor activity|signal transducer activity	cytosolic small ribosomal subunit|cytoplasm
YNR067C	YNR067C	DSE4	hom	Verified	3.29006602083628	0.000500819391434797	yes	34	0.000403748646843274	22	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION			Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother	cytokinesis, completion of separation	glucan endo-1,3-beta-D-glucosidase activity	fungal-type cell wall|extracellular region|cell septum
YDR326C	YDR326C	YSP2	hom	Verified	3.285565143886	0.000508890022109622	yes	35	0.000678778208247306	56	NA	FT		MITOCHONDRION		Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication	apoptotic process	molecular_function	mitochondrion
YFL040W_p	YFL040W	YFL040W	hom	Uncharacterized	3.2825289286427	0.000514402144788105	yes	36	0.000230091980906691	11	NA					Putative transporter, member of the sugar porter family; YFL040W is not an essential gene	transmembrane transport	substrate-specific transmembrane transporter activity	integral to membrane|membrane
YHL023C	YHL023C	NPR3	hom	Verified	3.28019293193975	0.000518680603551409	yes	37	0.000717727923248691	45	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO NUTRIENT LEVELS			Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair	meiosis|regulation of TOR signaling cascade|cellular response to amino acid starvation	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YGL202W	YGL202W	ARO8	hom	Verified	3.27603893575059	0.000526370232438815	yes	38	0.000144369625245986	9	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis	aromatic amino acid family metabolic process	aromatic-amino-acid:2-oxoglutarate aminotransferase activity|2-aminoadipate transaminase activity	cytoplasm
YDR100W	YDR100W	TVP15	hom	Verified	3.24587444465691	0.00058545233919674	yes	39	0.000471162657128739	16	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p	vesicle-mediated transport	molecular_function	COPI-coated vesicle|integral to membrane|integral to Golgi membrane
YML086C	YML086C	ALO1	hom	Verified	3.20171078882464	0.000683070412492728	yes	40	0.000182728255354881	12	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress	cellular response to oxidative stress|dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinono-1,4-lactone oxidase activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YDL094C_d	YDL094C	YDL094C	hom	Dubious	3.18832365259489	0.000715501331136087	yes	41	0.000345449231354651	20	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential	Unknown	Unknown	Unknown
YOR100C	YOR100C	CRC1	hom	Verified	3.15486911274898	0.000802850614329667	yes	42	0.000226011709389735	15	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation	fatty acid metabolic process	carnitine:acyl carnitine antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YEL045C_d	YEL045C	YEL045C	hom	Dubious	3.14845502689531	0.000820679887093968	yes	43	0.00312075349671697	48	NA					Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress	Unknown	Unknown	Unknown
YLR320W	YLR320W	MMS22	hom	Verified	3.12707543355504	0.000882773104803961	yes	44	0.000864900405447408	37	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation	replication fork processing|double-strand break repair|recombinational repair|meiotic sister chromatid segregation|response to DNA damage stimulus	molecular_function	Cul8-RING ubiquitin ligase complex|nucleus
YBL029C-A	YBL029C-A	YBL029C-A	hom	Verified	3.11532651088319	0.000918706993273315	yes	45	0.000817403437126538	30	NA	FT		PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica	biological_process	molecular_function	plasma membrane
YNL229C	YNL229C	URE2	hom	Verified	3.11437781543168	0.000921666426066119	yes	46	0.0075173018419221	165	NA	FF|FT	PROTEIN LOCALIZATION			Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion	regulation of nitrogen utilization|response to aluminum ion|protein urmylation|cytoplasmic sequestering of transcription factor	glutathione peroxidase activity|phosphoprotein binding|transcription corepressor activity	cytosol
YIL058W_d	YIL058W	YIL058W	hom	Dubious	3.10861375934785	0.000939836340159288	yes	47	0.00119788825465983	27	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL212W	YNL212W	VID27	hom	Verified	3.09737439215023	0.000976215591281288	yes	48	0.000920086252511944	29	NA					Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth	biological_process	molecular_function	cytoplasm
YLR046C_p	YLR046C	YLR046C	hom	Uncharacterized	3.04711286529245	0.00115525468307229	no	49	0.000854621127882112	28	NA					Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	biological_process	molecular_function	integral to membrane
YOR120W	YOR120W	GCY1	hom	Verified	3.04074781316976	0.00117995700302484	no	50	0.00422819685497343	50	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication	cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process	oxidoreductase activity|mRNA binding|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity	nucleus|cytoplasm
YKL061W_p	YKL061W	BLI1	hom	Uncharacterized	3.04035358481896	0.00118150276589501	no	51	0.000588538998812567	27	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YJL077W-B_p	YJL077W-B	YJL077W-B	hom	Uncharacterized	3.03713596033475	0.00119418850872152	no	52	0.00310213079034646	21	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YPL032C	YPL032C	SVL3	hom	Verified	3.02421351290333	0.001246402209396	no	53	0.00364052862594257	60	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS	SITE OF POLARIZED GROWTH		Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress	endocytosis	molecular_function	cellular bud|cellular bud neck|cytoplasm
YPL071C_p	YPL071C	YPL071C	hom	Uncharacterized	2.98268876944004	0.00142864193284309	no	54	0.000959780242154359	32	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YGR014W	YGR014W	MSB2	hom	Verified	2.95259772563298	0.00157556154925333	no	55	0.00562479549734406	48	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate	signal transduction involved in filamentous growth|osmosensory signaling pathway via Sho1 osmosensor|establishment of cell polarity|hyperosmotic response|response to osmotic stress	osmosensor activity	site of polarized growth|integral to plasma membrane
YOR223W	YOR223W	YOR223W	hom	Verified	2.94493172577632	0.00161512967279347	no	56	0.00176200741351402	33	NA	FT		ENDOPLASMIC RETICULUM		Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3	biological_process	molecular_function	fungal-type vacuole lumen|endoplasmic reticulum
YDR512C	YDR512C	EMI1	hom	Verified	2.92732694244057	0.00170944635387746	no	57	0.00210819570591937	37	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|MITOCHONDRION ORGANIZATION			Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs	ascospore formation|mitochondrial respiratory chain complex assembly|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YMR069W	YMR069W	NAT4	hom	Verified	2.92212136328249	0.00173828021861057	no	58	0.00337161467925444	38	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A	histone acetylation	histone acetyltransferase activity	nucleus|cytoplasm
YPR089W_p	YPR089W	YPR089W	hom	Uncharacterized	2.90504877663764	0.0018359793600449	no	59	0.00229444916128145	53	NA	FT		GOLGI APPARATUS		Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p	biological_process	molecular_function	cellular_component
YER038W-A_d	YER038W-A	YER038W-A	hom	Dubious	2.89436041111126	0.0018996589727201	no	60	0.00212434927058284	36	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria	Unknown	Unknown	Unknown
YDR281C	YDR281C	PHM6	hom	Verified	2.89343763489732	0.00190524977445966	no	61	0.00413352827882162	60	NA					Protein of unknown function, expression is regulated by phosphate levels	biological_process	molecular_function	fungal-type vacuole
YGR021W_p	YGR021W	YGR021W	hom	Uncharacterized	2.88348861232647	0.00196648433440087	no	62	0.00274383844874382	33	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YLR311C_d	YLR311C	YLR311C	hom	Dubious	2.87703196121081	0.00200717466713432	no	63	0.00235111738734194	36	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR157W	YGR157W	CHO2	hom	Verified	2.86754898980237	0.0020683237785063	no	64	0.00294347063861148	38	NA	FT	LIPID METABOLISM			Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis	phosphatidylcholine biosynthetic process	phosphatidylethanolamine N-methyltransferase activity	integral to membrane|endoplasmic reticulum
YLR372W	YLR372W	SUR4	hom	Verified	2.85332751126918	0.00216320038523183	no	65	0.0533654302429891	328	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM	ENDOPLASMIC RETICULUM		Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis	post-Golgi vesicle-mediated transport|fatty acid elongation|fatty acid biosynthetic process|sphingolipid biosynthetic process	fatty acid elongase activity	integral to membrane|endoplasmic reticulum
YMR319C	YMR319C	FET4	hom	Verified	2.85104434639889	0.00217879457806449	no	66	0.0152323650659182	164	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Low-affinity Fe(II) transporter of the plasma membrane	intracellular copper ion transport|zinc ion transport|low-affinity iron ion transport|copper ion import	copper ion transmembrane transporter activity|iron ion transmembrane transporter activity	integral to membrane|plasma membrane|integral to plasma membrane
YPR159C-A_p	YPR159C-A	YPR159C-A	hom	Uncharacterized	2.84132354892939	0.00224633530853358	no	67	0.000556753227083715	18	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YML084W_d	YML084W	YML084W	hom	Dubious	2.83756828147428	0.00227293112298504	no	68	0.000885538079341038	25	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL097C-B_p	YNL097C-B	YNL097C-B	hom	Uncharacterized	2.83444791359976	0.00229524702550459	no	69	0.000990164981371818	32	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YIL148W	YIL148W	RPL40A	hom	Verified	2.82722419849791	0.00234767209930876	no	70	0.00270835077508416	35	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION	NUCLEUS	RIBOSOME	Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	cytoplasmic translation|protein ubiquitination|ribosome biogenesis	structural constituent of ribosome|protein tag	cytosolic large ribosomal subunit
YLR122C_d	YLR122C	YLR122C	hom	Dubious	2.80742395364691	0.00249697347125556	no	71	0.00242337911300021	37	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C	Unknown	Unknown	Unknown
YHL004W	YHL004W	MRP4	hom	Verified	2.79811665852411	0.00257007719530375	no	72	0.00296974834459499	76	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome|tRNA binding	mitochondrion|mitochondrial small ribosomal subunit
YDR517W	YDR517W	GRH1	hom	Verified	2.79322911198862	0.00260923581368597	no	73	0.00102390035863834	20	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress	protein secretion|ER to Golgi vesicle-mediated transport|Golgi organization	molecular_function	COPII vesicle coat|cis-Golgi network|cytoplasm
YGR241C	YGR241C	YAP1802	hom	Verified	2.77651029056237	0.00274729478357126	no	74	0.00411935934364541	71	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication	endocytosis	clathrin binding	actin cortical patch
YPR067W	YPR067W	ISA2	hom	Verified	2.75821732875476	0.00290587724777528	no	75	0.00690354625438698	108	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations	iron-sulfur cluster assembly|biotin biosynthetic process	iron ion binding	mitochondrion|mitochondrial intermembrane space
YLR108C	YLR108C	YLR108C	hom	Verified	2.75017287343657	0.00297819157327725	no	76	0.00416892758948625	36	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus
YJR009C	YJR009C	TDH2	hom	Verified	2.74673981620387	0.00300954316411723	no	77	0.00112873419535225	38	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; TDH2 has a paralog, TDH3, that arose from the whole genome duplication	gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YGL014W	YGL014W	PUF4	hom	Verified	2.74133521225897	0.00305950227686689	no	78	0.00710805913781678	72	NA	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|TRANSLATION|GENE SILENCING			Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of translation|protein localization|negative regulation of chromatin silencing involved in replicative cell aging	mRNA binding	cytoplasm
YMR041C	YMR041C	ARA2	hom	Verified	2.73136637820662	0.00315361557946751	no	79	0.00268006925144384	19	NA	FT	OXIDATION-REDUCTION PROCESS			NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase	dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinose 1-dehydrogenase [NAD(P)+] activity	cellular_component
YPL116W	YPL116W	HOS3	hom	Verified	2.71546659915087	0.0033091225978621	no	80	0.00126603745367454	29	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH		Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats	regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation	histone deacetylase activity	nucleus|cellular bud neck|cytoplasm
YLR206W	YLR206W	ENT2	hom	Verified	2.69135667261139	0.00355810343585169	no	81	0.000947658842810876	27	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus	actin filament organization|endocytosis|actin cortical patch assembly	clathrin binding	mating projection tip|actin cortical patch
YBR034C	YBR034C	HMT1	hom	Verified	2.68666740787786	0.00360843867318059	no	82	0.00587674559132492	69	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region.	mRNA export from nucleus|negative regulation of DNA-dependent transcription, termination|positive regulation of transcription elongation from RNA polymerase II promoter|peptidyl-arginine methylation	protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity	nucleus
YDR315C	YDR315C	IPK1	hom	Verified	2.68510930541384	0.00362530447403946	no	83	0.0118783762090421	90	NA	FT		NUCLEUS		Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable	nuclear-transcribed mRNA catabolic process, non-stop decay|inositol phosphate biosynthetic process	inositol pentakisphosphate 2-kinase activity	nucleus
YJR060W	YJR060W	CBF1	hom	Verified	2.68448079841136	0.00363212779640175	no	84	0.00994879362761092	140	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME	KINETOCHORE	Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress	regulation of transcription from RNA polymerase II promoter in response to methionine|negative regulation of transcription from RNA polymerase II promoter|methionine biosynthetic process|chromosome segregation|Unknown|chromatin remodeling|negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II repressing transcription factor binding|centromeric DNA binding	chromosome, centromeric region|mitochondrion|nucleus|kinetochore
YDR346C	YDR346C	SVF1	hom	Verified	2.67119106038513	0.00377913060375323	no	85	0.0075904092015448	59	NA	FT	RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance	cellular response to oxidative stress	molecular_function	nucleus|cytoplasm
YML021C	YML021C	UNG1	hom	Verified	2.66258225701962	0.00387718071839864	no	86	0.00336771284479741	60	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus	DNA repair	uracil DNA N-glycosylase activity	mitochondrion|nucleus
YPR100W	YPR100W	MRPL51	hom	Verified	2.65665178324087	0.00394604574167351	no	87	0.00964798948655048	127	NA	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation|aerobic respiration	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGR235C	YGR235C	MOS2	hom	Verified	2.65395512670702	0.00397772027664879	no	88	0.00494878804641738	64	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YLR204W	YLR204W	QRI5	hom	Verified	2.64420986168998	0.00409409356822082	no	89	0.0167282367572711	151	NA	FF|FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA	mRNA processing	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YOR323C	YOR323C	PRO2	hom	Verified	2.64372771167275	0.00409992948492066	no	90	0.0379622002257418	343	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis	proline biosynthetic process	glutamate-5-semialdehyde dehydrogenase activity	nucleus|cytoplasm
YKL030W_d	YKL030W	YKL030W	hom	Dubious	2.6336966076012	0.00422304603735306	no	91	0.00216148975601221	48	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene MAE1	Unknown	Unknown	Unknown
YML053C_p	YML053C	YML053C	hom	Uncharacterized	2.62563770068315	0.00432434093193368	no	92	0.0040792553745263	25	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YNL135C	YNL135C	FPR1	hom	Verified	2.61607826744809	0.00444730832780497	no	93	0.00718886529487861	80	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION		Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function	protein folding|chromatin organization|homoserine metabolic process	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	mitochondrion|nucleus|cytoplasm
YER090W	YER090W	TRP2	hom	Verified	2.60690573693361	0.0045682254189091	no	94	0.139655494327567	642	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p	tryptophan biosynthetic process	anthranilate synthase activity	anthranilate synthase complex|cytoplasm
YDR244W	YDR244W	PEX5	hom	Verified	2.60304545046987	0.00461998516840834	no	95	0.00886083318273305	52	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions	protein import into peroxisome matrix, docking	peroxisome matrix targeting signal-1 binding|protein binding, bridging	cytosol|peroxisomal membrane|peroxisome
YDR277C	YDR277C	MTH1	hom	Verified	2.5888134392523	0.00481536276432956	no	96	0.00332616220824538	38	NA	FT	SIGNALING			Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation	glucose transport|signal transduction	molecular_function	cellular_component
YDR306C_p	YDR306C	YDR306C	hom	Uncharacterized	2.58477736293485	0.00487209476270488	no	97	0.00789474722907138	70	NA	FT	PROTEOLYSIS			F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YKR048C	YKR048C	NAP1	hom	Verified	2.58468485167391	0.00487340207637379	no	98	0.00496167057212475	98	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME		Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress	budding cell bud growth|M phase of mitotic cell cycle|nucleosome disassembly|protein import into nucleus|nucleosome assembly	cyclin binding|histone binding	nucleus|nuclear nucleosome|cytoplasm
YMR286W	YMR286W	MRPL33	hom	Verified	2.5728329088411	0.00504349466690273	no	99	0.00611726360014178	92	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDL018C	YDL018C	ERP3	hom	Verified	2.56356283766793	0.00518019725559212	no	100	0.00857967259924147	62	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YDR479C	YDR479C	PEX29	hom	Verified	2.56315581579539	0.00518627432704584	no	101	0.00587156383040083	102	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress	peroxisome organization	molecular_function	integral to membrane|peroxisomal membrane
YJL045W	YJL045W	YJL045W	hom	Verified	2.55677078346865	0.00528244040581505	no	102	0.00510997972090232	62	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner	cellular respiration	succinate dehydrogenase (ubiquinone) activity	mitochondrion
YKL183W	YKL183W	LOT5	hom	Verified	2.55539444546951	0.00530337628437764	no	103	0.00304619839258351	54	NA	FT		NUCLEUS		Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YGL203C	YGL203C	KEX1	hom	Verified	2.55412114315484	0.00532281053875798	no	104	0.00464655917338968	57	NA	FT	PROTEOLYSIS	GOLGI APPARATUS		Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins	protein processing	serine-type carboxypeptidase activity	trans-Golgi network
YKL207W	YKL207W	EMC3	hom	Verified	2.5457973900359	0.00545142249098086	no	105	0.00371204734950946	83	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|integral to membrane
YFL036W	YFL036W	RPO41	hom	Verified	2.53663430308222	0.00559619013114165	no	106	0.00610275558299446	84	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation	transcription from mitochondrial promoter|mitochondrial genome maintenance	DNA-directed RNA polymerase activity	mitochondrial nucleoid|mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix
YBR017C	YBR017C	KAP104	hom	Verified	2.5278619192222	0.00573797380052352	no	107	0.0045068453132642	65	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE	SITE OF POLARIZED GROWTH		Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis	protein import into nucleus|cell cycle|mRNA-binding (hnRNP) protein import into nucleus|transcription factor import into nucleus	nuclear localization sequence binding	cytosol|integral to membrane|cellular bud neck|cellular bud tip
YDR142C	YDR142C	PEX7	hom	Verified	2.52524078980034	0.00578095198784114	no	108	0.00754928023225578	61	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)	protein import into peroxisome matrix, docking	peroxisome matrix targeting signal-2 binding	cytosol|peroxisome
YDR198C	YDR198C	RKM2	hom	Verified	2.52398783377857	0.00580159721087545	no	109	0.00814670731461961	49	NA					Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp	peptidyl-lysine trimethylation|peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	cellular_component
YDL063C	YDL063C	SYO1	hom	Verified	2.51844817192246	0.00589366148345226	no	110	0.0110899584520418	68	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	ribosomal large subunit biogenesis	molecular_function	nucleus|cytoplasm
YPR030W	YPR030W	CSR2	hom	Verified	2.51704394768233	0.00591720333093982	no	111	0.00858400499187078	67	NA	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS	NUCLEUS		Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication	fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	nucleus
YJR087W_d	YJR087W	YJR087W	hom	Dubious	2.5169095824416	0.00591946033257426	no	112	0.00451529897352602	59	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2	Unknown	Unknown	Unknown
YAL060W	YAL060W	BDH1	hom	Verified	2.51019199575324	0.00603327676701322	no	113	0.0076447070901976	56	NA	FT	OXIDATION-REDUCTION PROCESS			NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source	alcohol metabolic process|butanediol biosynthetic process	(R,R)-butanediol dehydrogenase activity	cytoplasm
YLR062C_d	YLR062C	BUD28	hom	Dubious	2.48622159563458	0.00645537723320841	no	114	0.0105395678236024	73	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YML090W_d	YML090W	YML090W	hom	Dubious	2.48000262931159	0.00656907069508048	no	115	0.00565246290528563	51	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source	Unknown	Unknown	Unknown
YDR294C	YDR294C	DPL1	hom	Verified	2.47871770436942	0.00659278086311891	no	116	0.00351305332246248	43	NA	FT	KETONE METABOLISM|LIPID METABOLISM|SIGNALING|RESPONSE TO NUTRIENT LEVELS	ENDOPLASMIC RETICULUM		Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate	calcium-mediated signaling|sphingolipid metabolic process|cellular response to starvation	sphinganine-1-phosphate aldolase activity	endoplasmic reticulum|cortical endoplasmic reticulum|perinuclear endoplasmic reticulum
YBR274W	YBR274W	CHK1	hom	Verified	2.46837980532334	0.00678631123835288	no	117	0.00414678871334924	38	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase	protein phosphorylation|replication fork protection|DNA damage checkpoint	protein serine/threonine kinase activity	nucleus
YDL066W	YDL066W	IDP1	hom	Verified	2.46504254763281	0.00684984913403263	no	118	0.0250618372143921	206	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes	isocitrate metabolic process|glutamate biosynthetic process	isocitrate dehydrogenase (NADP+) activity	mitochondrial nucleoid|mitochondrion
YEL036C	YEL036C	ANP1	hom	Verified	2.45882410064604	0.00696964476899944	no	119	0.0167728822465052	155	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity|mannosyltransferase activity	alpha-1,6-mannosyltransferase complex|Golgi cis cisterna
YIR033W	YIR033W	MGA2	hom	Verified	2.45423386792275	0.00705925635014044	no	120	0.00710952538024499	57	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	molecular_function	integral to endoplasmic reticulum membrane|nucleus
YER164W	YER164W	CHD1	hom	Verified	2.44825198284144	0.00717756111204985	no	121	0.012665730572068	110	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes	termination of RNA polymerase I transcription|ATP-dependent chromatin remodeling|nucleosome positioning|negative regulation of histone H3-K14 acetylation|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|regulation of transcriptional start site selection at RNA polymerase II promoter|nucleosome mobilization|Unknown|transcription elongation from RNA polymerase II promoter	chromatin DNA binding|DNA-dependent ATPase activity|methylated histone residue binding|DNA binding|rDNA binding	nuclear chromatin|SLIK (SAGA-like) complex|mitochondrion|SAGA complex|nucleolar chromatin
YIL042C	YIL042C	PKP1	hom	Verified	2.43898252243275	0.00736434029405389	no	122	0.0031844618233484	20	NA	FT	SIGNALING|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p	peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization	protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity	mitochondrion
YDR179C	YDR179C	CSN9	hom	Verified	2.43810519414665	0.00738223839834783	no	123	0.00628911269903602	39	NA	FT	SIGNALING	NUCLEUS		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	molecular_function	signalosome
YCL023C_d	YCL023C	YCL023C	hom	Dubious	2.43697324055215	0.00740538766903462	no	124	0.00420297837898314	29	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4	Unknown	Unknown	Unknown
YMR285C	YMR285C	NGL2	hom	Verified	2.42841281729411	0.00758253534471642	no	125	0.00365887305796399	66	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication	rRNA processing	endoribonuclease activity	intracellular
YNL065W	YNL065W	AQR1	hom	Verified	2.41474698431219	0.00787307171325529	no	126	0.00451933039751371	53	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress	monocarboxylic acid transport|drug transmembrane transport|amino acid export	monocarboxylic acid transmembrane transporter activity|drug transmembrane transporter activity	integral to membrane|plasma membrane
YGR051C_d	YGR051C	YGR051C	hom	Dubious	2.41383309509724	0.00789284580913054	no	127	0.00539620450872408	54	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene	Unknown	Unknown	Unknown
YER111C	YER111C	SWI4	hom	Verified	2.41018059108261	0.00797231297131477	no	128	0.009596043035866	131	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS|CHROMOSOME		DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	SBF transcription complex|nuclear chromatin
YGR096W	YGR096W	TPC1	hom	Verified	2.40926237423084	0.00799240084649855	no	129	0.0103285216428459	44	NA	FT		MITOCHONDRION		Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family	thiamine pyrophosphate transport	thiamine transmembrane transporter activity	integral to membrane|integral to mitochondrial inner membrane
YNR042W_d	YNR042W	YNR042W	hom	Dubious	2.40623299505722	0.00805899067422428	no	130	0.00457268695417715	72	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2	Unknown	Unknown	Unknown
YGL166W	YGL166W	CUP2	hom	Verified	2.39972258837571	0.00820375049610441	no	131	0.00973091103358435	64	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter|response to copper ion	RNA polymerase II core promoter proximal region sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|copper ion binding	nucleus
YHR044C	YHR044C	DOG1	hom	Verified	2.39929028213408	0.00821344326533302	no	132	0.00397596322059087	78	NA	FT	CARBOHYDRATE METABOLISM			2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified	glucose metabolic process	2-deoxyglucose-6-phosphatase activity	cellular_component
YOL023W	YOL023W	IFM1	hom	Verified	2.39649755763524	0.00827630189969585	no	133	0.0152105976540593	154	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation initiation factor 2	translational initiation|mitochondrial translational initiation|mitochondrial translation	tRNA binding|GTPase activity|translation initiation factor activity	mitochondrion
YBR008C	YBR008C	FLR1	hom	Verified	2.39596449644117	0.00828834794220698	no	134	0.00547501547860158	116	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress	drug transmembrane transport|transmembrane transport	fluconazole transporter activity|drug transmembrane transporter activity	integral to membrane|plasma membrane
YJR108W	YJR108W	ABM1	hom	Verified	2.39509817987736	0.00830795769056532	no	135	0.00570319436279621	53	NA	FT	CYTOSKELETON ORGANIZATION			Protein of unknown function, required for normal microtubule organization	microtubule cytoskeleton organization	molecular_function	cellular_component
YOR064C	YOR064C	YNG1	hom	Verified	2.39177141241749	0.00838364079650589	no	136	0.00976222536724546	94	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1	histone acetylation|chromatin modification	histone acetyltransferase activity|methylated histone residue binding	NuA3 histone acetyltransferase complex
YGL076C	YGL076C	RPL7A	hom	Verified	2.38211498654463	0.00860676077907791	no	137	0.00876523676603056	87	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit|cytoplasm
YOL109W	YOL109W	ZEO1	hom	Verified	2.36707174564633	0.0089647283638967	no	138	0.0103767562546423	77	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria	fungal-type cell wall organization|response to stress	molecular_function	mitochondrial outer membrane|mitochondrion|extrinsic to plasma membrane|plasma membrane
YPR166C	YPR166C	MRP2	hom	Verified	2.36013986036121	0.00913402316083537	no	139	0.0175006069403162	124	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YJR005C-A_p	YJR005C-A	YJR005C-A	hom	Uncharacterized	2.3542128178391	0.0092809902421782	no	140	0.0066529920898595	73	NA					Putative protein of unknown function; originally identified as a syntenic homolog of an <i>Ashbya gossypii</i> gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YNL053W	YNL053W	MSG5	hom	Verified	2.35322995367409	0.00930556034558365	no	141	0.0116447000057115	99	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|regulation of fungal-type cell wall organization|inactivation of MAPK activity involved in cell wall biogenesis|regulation of MAPK export from nucleus|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion	protein tyrosine/serine/threonine phosphatase activity	nucleus|cytoplasm
YAL013W	YAL013W	DEP1	hom	Verified	2.34550721112419	0.00950060551356992	no	142	0.00944924969360139	114	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|regulation of DNA-dependent DNA replication initiation|Unknown	molecular_function	Rpd3L-Expanded complex|Rpd3L complex
YGL017W	YGL017W	ATE1	hom	Verified	2.33048017106011	0.00989039342179701	no	143	0.00502134231291758	63	NA	FT	PROTEOLYSIS			Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway	cellular protein modification process|protein arginylation	arginyltransferase activity	cytoplasm
YDR197W	YDR197W	CBS2	hom	Verified	2.32924562297862	0.00992302862128365	no	144	0.0215518080059362	111	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader	mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial ribosome
YAL016C-B_d	YAL016C-B	YAL016C-B	hom	Dubious	2.31832135639696	0.0102159312936044	no	145	0.00644830698731023	79	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL085W_p	YGL085W	LCL3	hom	Uncharacterized	2.31774207415206	0.0102316714603996	no	146	0.00715139043202745	80	NA	FT		MITOCHONDRION		Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	mitochondrion
YLR433C	YLR433C	CNA1	hom	Verified	2.31276109176756	0.010367889038278	no	147	0.00508997338027551	83	NA	FT	SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity	calcineurin complex|cytoplasm
YMR119W-A_d	YMR119W-A	YMR119W-A	hom	Dubious	2.31209465619064	0.0103862337929964	no	148	0.0101154777103345	87	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR040W	YMR040W	YET2	hom	Verified	2.31111386178114	0.0104132832621657	no	149	0.0124181993148902	33	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein	biological_process	molecular_function	ribosome|integral to membrane
YDR336W_p	YDR336W	YDR336W	hom	Uncharacterized	2.30947874582482	0.010458514884275	no	150	0.0132144848335653	104	NA					Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene	biological_process	molecular_function	cellular_component
YJR095W	YJR095W	SFC1	hom	Verified	2.3094398518899	0.0104595928747799	no	151	0.00850336562148185	88	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization	succinate transport|fumarate transport	succinate:fumarate antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YOR205C	YOR205C	GEP3	hom	Verified	2.30855385841039	0.0104841754522973	no	152	0.0112047806643956	140	NA	FT		MITOCHONDRION		Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1)	maturation of SSU-rRNA	molecular_function	mitochondrion|mitochondrial inner membrane
YDR266C	YDR266C	HEL2	hom	Verified	2.30482359792953	0.0105882274624559	no	153	0.0116299977889476	62	NA					RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor	biological_process	molecular_function	ribosome|cytoplasm
YER107C	YER107C	GLE2	hom	Verified	2.30167685631291	0.0106767011531574	no	154	0.0315638668341379	241	NA	FF|FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1	poly(A)+ mRNA export from nucleus|Unknown|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear pore distribution|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	molecular_function	integral to membrane|nuclear pore|cytoplasm
YBR221W-A_p	YBR221W-A	YBR221W-A	hom	Uncharacterized	2.29655564653688	0.0108220656495045	no	155	0.00785025596870063	85	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YDR129C	YDR129C	SAC6	hom	Verified	2.29635917896739	0.0108276764899834	no	156	0.0867768372444589	430	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress	bipolar cellular bud site selection|actin filament organization|endocytosis|response to osmotic stress	actin filament binding|protein binding, bridging	actin filament bundle|mating projection tip|actin cortical patch
YLR082C	YLR082C	SRL2	hom	Verified	2.27858792607761	0.0113457861709635	no	157	0.0114970976037454	70	NA	FT		NUCLEUS		Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation	nucleobase-containing compound metabolic process	molecular_function	nucleus|cytoplasm
YPR151C	YPR151C	SUE1	hom	Verified	2.27643032022285	0.0114101333349458	no	158	0.00410009666593621	28	NA	FT	PROTEOLYSIS	MITOCHONDRION		Mitochondrial protein required for degradation of unstable forms of cytochrome c	protein catabolic process	molecular_function	mitochondrial envelope
YFL042C_p	YFL042C	YFL042C	hom	Uncharacterized	2.27381641292647	0.011488513501554	no	159	0.0130285012282434	65	NA					Putative protein of unknown function; YFL042C is not an essential gene	biological_process	molecular_function	cellular_component
YDR234W	YDR234W	LYS4	hom	Verified	2.27370797702474	0.0114917751197135	no	160	0.0129443885949844	96	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway	lysine biosynthetic process via aminoadipic acid	homoaconitate hydratase activity	mitochondrion
YKR027W	YKR027W	BCH2	hom	Verified	2.27140819838628	0.011561139286586	no	161	0.0116887123635551	93	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	MITOCHONDRION|GOLGI APPARATUS		Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication	Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process	molecular_function	trans-Golgi network transport vesicle|mitochondrion|clathrin-coated vesicle|exomer complex
YKL094W	YKL094W	YJU3	hom	Verified	2.27109620407896	0.011570577372014	no	162	0.0109780089834231	76	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM|MITOCHONDRION		Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family	triglyceride metabolic process	serine hydrolase activity|acylglycerol lipase activity	mitochondrial outer membrane|lipid particle|plasma membrane|membrane|cytoplasm
YNL269W	YNL269W	BSC4	hom	Verified	2.26712784987384	0.0116912083628577	no	163	0.0084743293402808	93	NA					Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p	biological_process	molecular_function	cellular_component
YBR047W_p	YBR047W	FMP23	hom	Uncharacterized	2.26464389641526	0.0117672704422511	no	164	0.0101948393082466	85	NA	FT		MITOCHONDRION		Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YJR074W	YJR074W	MOG1	hom	Verified	2.25421931321781	0.0120911871897364	no	165	0.0144300877000549	139	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p	protein import into nucleus	Ran GTPase binding	nucleus
YPL103C	YPL103C	FMP30	hom	Verified	2.25248160589572	0.012145926917231	no	166	0.0111111893527046	112	NA	FT	LIPID METABOLISM	MITOCHONDRION		Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D	N-acylphosphatidylethanolamine metabolic process|N-acylethanolamine metabolic process	NAPE-specific phospholipase D activity	mitochondrion|integral to mitochondrial inner membrane
YBR048W	YBR048W	RPS11B	hom	Verified	2.25020098069751	0.0122180950398314	no	167	0.0154836474569373	122	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YGL231C	YGL231C	EMC4	hom	Verified	2.24947578772532	0.0122411207854872	no	168	0.0197333791850365	113	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YOR345C_d	YOR345C	YOR345C	hom	Dubious	2.24154153142594	0.0124955092290412	no	169	0.0120308867581138	81	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	Unknown	Unknown	Unknown
YFR015C	YFR015C	GSY1	hom	Verified	2.24148214677331	0.0124974303514911	no	170	0.00537657773313501	52	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	glycogen biosynthetic process	glycogen (starch) synthase activity	mitochondrion|cytoplasm
YPL133C	YPL133C	RDS2	hom	Verified	2.2332951865124	0.0127647423705756	no	171	0.0058863260779545	55	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|cellular response to xenobiotic stimulus|positive regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YDL174C	YDL174C	DLD1	hom	Verified	2.22764394463897	0.0129521338900879	no	172	0.00589937694784406	42	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane	cellular carbohydrate metabolic process|aerobic respiration	D-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial inner membrane
YGL041C_d	YGL041C	YGL041C	hom	Dubious	2.22434760531672	0.0130625330470669	no	173	0.0176585594887583	111	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR239C	YGR239C	PEX21	hom	Verified	2.22319573267735	0.0131013022326858	no	174	0.0159486028928375	97	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress	protein import into peroxisome matrix|positive regulation of protein binding	protein binding	cytosol|peroxisome
YJL058C	YJL058C	BIT61	hom	Verified	2.22253429038297	0.0131236096637414	no	175	0.0085289654007304	48	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication	fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity	molecular_function	TORC2 complex|plasma membrane|cytoplasm
YDR072C	YDR072C	IPT1	hom	Verified	2.22073935980666	0.0131843099569095	no	176	0.0130119841686209	142	NA	FT	LIPID METABOLISM			Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin	mannosyl diphosphorylinositol ceramide metabolic process|sphingolipid biosynthetic process	transferase activity, transferring phosphorus-containing groups	integral to membrane
YCR017C	YCR017C	CWH43	hom	Verified	2.2146836985998	0.0133908912674371	no	177	0.0235976011071727	167	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion	fungal-type cell wall organization|GPI anchor biosynthetic process	molecular_function	integral to membrane|integral to plasma membrane|cellular bud neck|cellular bud tip
YGL149W_d	YGL149W	YGL149W	hom	Dubious	2.21463195089356	0.0133926685524643	no	178	0.0109058149671908	65	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.	Unknown	Unknown	Unknown
YLR438W	YLR438W	CAR2	hom	Verified	2.21424690545905	0.0134058994106068	no	179	0.0135331996839947	103	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress	ornithine metabolic process|arginine catabolic process	ornithine-oxo-acid transaminase activity	cytosol|nucleus|cytoplasm
YNL063W	YNL063W	MTQ1	hom	Verified	2.21224381519754	0.0134749114521059	no	180	0.0145746320779253	89	NA	FT	TRANSLATION	MITOCHONDRION		S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene	translational readthrough	S-adenosylmethionine-dependent methyltransferase activity	mitochondrion
YLR042C_p	YLR042C	YLR042C	hom	Uncharacterized	2.21097416047282	0.01351881323109	no	181	0.00820128969494827	57	NA					Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene	biological_process	molecular_function	fungal-type cell wall
YDL083C	YDL083C	RPS16B	hom	Verified	2.20915968648951	0.0135817679036873	no	182	0.0233132999987673	89	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YML034W	YML034W	SRC1	hom	Verified	2.20869900719655	0.0135977917690397	no	183	0.0245342693130526	210	NA	FF|FT	CELL CYCLE|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance	maintenance of rDNA|mitotic sister chromatid segregation	molecular_function	nuclear envelope
YDR157W_d	YDR157W	YDR157W	hom	Dubious	2.20738757983857	0.0136434966712153	no	184	0.0122816514556342	83	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR131W	YGR131W	FHN1	hom	Verified	2.19892714649488	0.013941551497774	no	185	0.0162098326182014	82	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain	establishment of protein localization to plasma membrane	molecular_function	integral to membrane|membrane raft
YDR496C	YDR496C	PUF6	hom	Verified	2.19478910695151	0.0140893646212377	no	186	0.00877538907375266	64	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS|SITE OF POLARIZED GROWTH	RIBOSOME	Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis	ribosomal large subunit biogenesis|negative regulation of translation	mRNA 3'-UTR binding|translation repressor activity, nucleic acid binding	nucleolus|nucleus|large ribosomal subunit
YBR010W	YBR010W	HHT1	hom	Verified	2.19259920291927	0.0141681343056157	no	187	0.0171396851152167	127	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation	chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint	DNA binding	replication fork protection complex|nucleus|nuclear nucleosome
YHR066W	YHR066W	SSF1	hom	Verified	2.19115871801001	0.0142201544057776	no	188	0.0131491746703152	99	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication	conjugation with cellular fusion|ribosomal large subunit assembly|regulation of cell size	rRNA binding	nucleolus
YHR126C_p	YHR126C	ANS1	hom	Uncharacterized	2.19003267903255	0.0142609334502776	no	189	0.0132101416401638	106	NA	FT		PLASMA MEMBRANE		Putative GPI protein; transcription dependent upon Azf1p	biological_process	molecular_function	cellular_component
YGL086W	YGL086W	MAD1	hom	Verified	2.17187970393023	0.0149323688670689	no	190	0.0120559659375372	96	NA	FT	CELL CYCLE|CELL DIVISION	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME	NUCLEAR PORE|KINETOCHORE	Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p	nucleocytoplasmic transport|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	nucleus|nuclear pore|kinetochore
YBL095W_p	YBL095W	YBL095W	hom	Uncharacterized	2.17104390759184	0.0149639267482351	no	191	0.0160631716773619	137	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YDR263C	YDR263C	DIN7	hom	Verified	2.17085340783938	0.0149711276288799	no	192	0.0172853108994865	112	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination	DNA repair	nuclease activity	mitochondrion
YBL078C	YBL078C	ATG8	hom	Verified	2.16556333638751	0.0151722853015538	no	193	0.025057168108438	177	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM		Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose &#65532;conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis	piecemeal microautophagy of nucleus|mitochondrion degradation|cellular membrane fusion|ER to Golgi vesicle-mediated transport|CVT pathway|autophagic vacuole assembly	molecular_function	cytosol|fungal-type vacuole membrane|pre-autophagosomal structure|extrinsic to membrane|autophagic vacuole
YOL112W	YOL112W	MSB4	hom	Verified	2.16234707720075	0.0152957167841764	no	194	0.0161363324812467	126	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization	actin filament organization	Rab GTPase activator activity	incipient cellular bud site|polarisome|cellular bud tip
YIL133C	YIL133C	RPL16A	hom	Verified	2.16120972089749	0.0153395714254492	no	195	0.0190756645384871	144	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YGR043C	YGR043C	NQM1	hom	Verified	2.15391196379112	0.0156235382787336	no	196	0.0126463825398583	81	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift	biological_process	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	nucleus
YBL021C	YBL021C	HAP3	hom	Verified	2.14795446267289	0.0158586865795818	no	197	0.0176369296833777	58	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex
YDR505C	YDR505C	PSP1	hom	Verified	2.14653630235959	0.0159151078464531	no	198	0.0112698553697024	73	NA	FT		MITOCHONDRION		Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|cytoplasm
YJL105W	YJL105W	SET4	hom	Verified	2.14233090688357	0.0160834317285756	no	199	0.0183825950465767	193	NA	FT	CHROMATIN ORGANIZATION			Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YFR017C	YFR017C	IGD1	hom	Verified	2.14199391956133	0.0160969856633123	no	200	0.0148521823936546	91	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication	negative regulation of glycogen catabolic process	enzyme inhibitor activity	cytoplasm
YJL106W	YJL106W	IME2	hom	Verified	2.13495938543158	0.0163821639017739	no	201	0.0135152310350251	68	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p	protein phosphorylation|regulation of meiosis	protein kinase activity	nucleus
YBL062W_d	YBL062W	YBL062W	hom	Dubious	2.12934426220905	0.0166128941421721	no	202	0.024751051044792	161	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL057C	YPL057C	SUR1	hom	Verified	2.12881652435153	0.0166347216177908	no	203	0.0136988686807873	160	NA	FT	LIPID METABOLISM			Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication	glycosphingolipid biosynthetic process|mannosyl-inositol phosphorylceramide metabolic process|sphingolipid biosynthetic process	mannosyltransferase activity|transferase activity, transferring glycosyl groups	integral to membrane|intracellular
YPL158C	YPL158C	AIM44	hom	Verified	2.12656463082598	0.0167281369345932	no	204	0.0304879464477866	160	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cellular bud neck
YPL186C	YPL186C	UIP4	hom	Verified	2.12053397140914	0.0169805198923309	no	205	0.0288917910821395	140	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope	biological_process	molecular_function	mitochondrial outer membrane|nuclear envelope|endoplasmic reticulum
YLR398C	YLR398C	SKI2	hom	Verified	2.11998637338727	0.017003597237142	no	206	0.0202698398029814	121	NA	FT	TRANSLATION			Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay	RNA helicase activity	Ski complex
YJL110C	YJL110C	GZF3	hom	Verified	2.11574056007672	0.0171834394598224	no	207	0.0232859036078633	140	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication	maintenance of protein location in nucleus|nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YHR035W_p	YHR035W	YHR035W	hom	Uncharacterized	2.10998899644799	0.0174296518377311	no	208	0.00660263844901759	84	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Putative protein of unknown function; not an essential gene	biological_process	molecular_function	cellular_component
YLR213C	YLR213C	CRR1	hom	Verified	2.10144786660298	0.0178008349210403	no	209	0.0105465071431065	75	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation	ascospore wall assembly	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	ascospore wall
YDL049C	YDL049C	KNH1	hom	Verified	2.0942089681665	0.0181206846159404	no	210	0.0143479765476953	82	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance	(1->6)-beta-D-glucan biosynthetic process	molecular_function	fungal-type cell wall|extracellular region
YPL025C_d	YPL025C	YPL025C	hom	Dubious	2.08944567574935	0.0183338116257268	no	211	0.0211702262108465	135	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL138C_p	YGL138C	YGL138C	hom	Uncharacterized	2.08815112653	0.0183921021847098	no	212	0.013577902172909	71	NA					Putative protein of unknown function; has no significant sequence similarity to any known protein	biological_process	molecular_function	cellular_component
YDL131W	YDL131W	LYS21	hom	Verified	2.08781163692463	0.018407414718374	no	213	0.00890313444385706	75	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication	lysine biosynthetic process via aminoadipic acid	homocitrate synthase activity	nucleus
YGL094C	YGL094C	PAN2	hom	Verified	2.08222840730462	0.0186608058427226	no	214	0.0231377840419742	123	NA	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEOLYSIS			Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes	mRNA 3'-end processing|postreplication repair|mRNA processing	poly(A)-specific ribonuclease activity	PAN complex|cytoplasm
YPR159W	YPR159W	KRE6	hom	Verified	2.07943413178764	0.0187887330372227	no	215	0.0345027207340841	165	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p	fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process	glucosidase activity	integral to endoplasmic reticulum membrane|integral to membrane|site of polarized growth|transport vesicle|plasma membrane
YJR146W_p	YJR146W	YJR146W	hom	Uncharacterized	2.07717738456303	0.0188925951866163	no	216	0.0128830247292765	83	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2	biological_process	molecular_function	cellular_component
YDL039C	YDL039C	PRM7	hom	Verified	2.07193318712069	0.0191358362375609	no	217	0.0163948775931954	70	NA					Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements	conjugation with cellular fusion	molecular_function	integral to membrane
YLR406C-A_p	YLR406C-A	YLR406C-A	hom	Uncharacterized	2.07137513780913	0.0191618762255355	no	218	0.0210119363132194	100	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR315W	YMR315W	YMR315W	hom	Verified	2.06849983352728	0.0192965231241128	no	219	0.0205700579278901	157	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress	NADPH regeneration	oxidoreductase activity	nucleus|cytoplasm
YMR070W	YMR070W	MOT3	hom	Verified	2.06689915997642	0.0193718284605235	no	220	0.0334388951868971	233	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion	cellular hyperosmotic response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ergosterol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	nucleus
YBR042C	YBR042C	CST26	hom	Verified	2.06116173855806	0.0196438062070821	no	221	0.0171082330738416	144	NA	FT	LIPID METABOLISM			Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication	phospholipid biosynthetic process	transferase activity, transferring acyl groups	lipid particle
YDR411C	YDR411C	DFM1	hom	Verified	2.05657840904154	0.0198633984297428	no	222	0.0108821775486917	98	NA	FT	SIGNALING|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p	endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process	molecular_function	Doa10p ubiquitin ligase complex|integral to membrane|endoplasmic reticulum|Hrd1p ubiquitin ligase ERAD-L complex
YDR261C	YDR261C	EXG2	hom	Verified	2.0524065488735	0.0200650843078786	no	223	0.0141059762339761	134	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	fungal-type cell wall organization	glucan exo-1,3-beta-glucosidase activity	fungal-type cell wall
YGR168C_p	YGR168C	YGR168C	hom	Uncharacterized	2.04873556694063	0.0202439896581334	no	224	0.0385720139252769	208	NA					Putative protein of unknown function; YGR168C is not an essential gene	biological_process	molecular_function	integral to membrane
YHR139C	YHR139C	SPS100	hom	Verified	2.04611011670669	0.0203727689360448	no	225	0.0255218113602052	176	NA	FT	KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS			Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin	ascospore wall assembly	molecular_function	ascospore wall
YPL104W	YPL104W	MSD1	hom	Verified	2.04151946634355	0.020599610493712	no	226	0.0346260752260384	209	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene	mitochondrial aspartyl-tRNA aminoacylation	aspartate-tRNA ligase activity	mitochondrion
YJL146W	YJL146W	IDS2	hom	Verified	2.04039852489529	0.0206553243572003	no	227	0.0162698346116589	94	NA	FT	CELL CYCLE	NUCLEUS		Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation	meiosis	molecular_function	nucleus|cytoplasm
YML017W	YML017W	PSP2	hom	Verified	2.03682008656736	0.0208340373207012	no	228	0.0312257836823352	210	NA					Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing	biological_process	molecular_function	cytoplasm
YOR239W	YOR239W	ABP140	hom	Verified	2.03218008643624	0.021067714048565	no	229	0.0174609565647721	96	NA	FT	RNA PROCESSING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift	actin filament bundle assembly|tRNA methylation	tRNA (cytosine-3-)-methyltransferase activity|actin filament binding|protein binding, bridging	actin filament|actin filament bundle|mating projection tip|actin cortical patch
YDR179W-A_p	YDR179W-A	YDR179W-A	hom	Uncharacterized	2.03054663511214	0.0211505029237498	no	230	0.0205947405354216	124	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPR049C	YPR049C	ATG11	hom	Verified	2.02574184217581	0.0213956232364671	no	231	0.0281994833950111	178	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION			Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)	piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|protein localization to pre-autophagosomal structure|CVT pathway	protein complex scaffold	pre-autophagosomal structure|extrinsic to membrane
YLR187W	YLR187W	SKG3	hom	Verified	2.02367671172268	0.0215017131384227	no	232	0.0204894372372421	120	NA	FT		SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication	biological_process	molecular_function	cellular bud|cellular bud neck|cytoplasm
YPR139C	YPR139C	LOA1	hom	Verified	2.02047987698023	0.0216668176908183	no	233	0.0408292057092751	207	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA	lipid particle organization|cellular triglyceride homeostasis|protein targeting to vacuole	lysophosphatidic acid acyltransferase activity	endoplasmic reticulum|lipid particle|cytoplasm
YLR453C	YLR453C	RIF2	hom	Verified	2.01926161408907	0.0217300176721831	no	234	0.0177895368649698	172	NA	FT		NUCLEUS|CHROMOSOME		Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation	telomere capping|telomere maintenance via telomerase	telomeric DNA binding	nuclear telomere cap complex
YJR058C	YJR058C	APS2	hom	Verified	2.01831061409368	0.021779460991697	no	235	0.00805314008714241	50	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YKL137W	YKL137W	CMC1	hom	Verified	2.01816148774682	0.0217872228129417	no	236	0.02028603084259	147	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif	mitochondrial respiratory chain complex IV assembly	copper ion binding	extrinsic to mitochondrial inner membrane|mitochondrial intermembrane space
YLR363C	YLR363C	NMD4	hom	Verified	2.01592843739712	0.0219037297379546	no	237	0.0212053174226951	131	NA					Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	molecular_function	cytoplasm
YMR191W	YMR191W	SPG5	hom	Verified	2.01572576282689	0.021914330051852	no	238	0.0257556440040421	129	NA					Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	biological_process	molecular_function	cellular_component
YLR325C	YLR325C	RPL38	hom	Verified	1.99333425016123	0.0231124291672759	no	239	0.0349027519699992	161	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR020C	YGR020C	VMA7	hom	Verified	1.98927960631128	0.0233351746952383	no	240	0.0544911545973107	287	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YLR154C	YLR154C	RNH203	hom	Verified	1.9865228371667	0.0234876498161272	no	241	0.0162020153687674	87	NA	FT		NUCLEUS		Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome	RNA catabolic process|DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus|cytoplasm
YOR290C	YOR290C	SNF2	hom	Verified	1.98185630589601	0.0237476627329572	no	242	0.079456859478614	355	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|double-strand break repair|strand invasion|positive regulation of mating type switching|sucrose catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|nucleosome mobilization|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter	histone acetyl-lysine binding|RNA polymerase II activating transcription factor binding|DNA-dependent ATPase activity|nucleosomal DNA binding	SWI/SNF complex|nucleus
YDR215C_d	YDR215C	YDR215C	hom	Dubious	1.98173368932097	0.0237545272656974	no	243	0.0226171122742109	81	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein	Unknown	Unknown	Unknown
YBL010C_p	YBL010C	YBL010C	hom	Uncharacterized	1.97291929523176	0.0242523789520506	no	244	0.0232975921347088	166	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles	biological_process	molecular_function	clathrin-coated vesicle
YMR135W-A_d	YMR135W-A	YMR135W-A	hom	Dubious	1.96407111194258	0.0247609228808671	no	245	0.0127862410597576	78	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR050C_p	YGR050C	YGR050C	hom	Uncharacterized	1.9617492123079	0.0248958446190347	no	246	0.0203870486997279	130	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YKL069W	YKL069W	YKL069W	hom	Verified	1.95769946018536	0.0251326443163436	no	247	0.0183903848800289	169	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress	cellular response to oxidative stress	methionine-R-sulfoxide reductase activity	nucleus|cytoplasm
YML081C-A	YML081C-A	ATP18	hom	Verified	1.95408874968079	0.0253453611739623	no	248	0.0183562543920007	87	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms	mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YDR492W	YDR492W	IZH1	hom	Verified	1.95101559805438	0.0255275951565695	no	249	0.0233462278629488	162	NA	FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc	response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process	metal ion binding	integral to membrane|endoplasmic reticulum|membrane
YOR099W	YOR099W	KTR1	hom	Verified	1.9500947121885	0.0255824156978036	no	250	0.0177562891323165	130	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress	N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YOL013C	YOL013C	HRD1	hom	Verified	1.94843016038519	0.0256817569531257	no	251	0.0135348752531803	151	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon	fungal-type cell wall organization|ER-associated protein catabolic process	ubiquitin-protein ligase activity	Hrd1p ubiquitin ligase ERAD-M complex|integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YDL051W	YDL051W	LHP1	hom	Verified	1.94142250132032	0.026103525596997	no	252	0.0267112252416152	143	NA	FT	RNA PROCESSING	NUCLEUS		RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen	tRNA processing	RNA binding|tRNA binding	nucleoplasm|nucleolus|nucleus
YJL172W	YJL172W	CPS1	hom	Verified	1.94056350548051	0.0261556221461327	no	253	0.0346960217897457	134	NA	FT	PROTEOLYSIS			Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions	nitrogen compound metabolic process|proteolysis involved in cellular protein catabolic process	carboxypeptidase activity	fungal-type vacuole lumen
YGL144C	YGL144C	ROG1	hom	Verified	1.93948381397258	0.0262212267805063	no	254	0.0304146438184286	151	NA	FT	LIPID METABOLISM			Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication	cellular lipid metabolic process	lipase activity	cellular_component
YOR045W	YOR045W	TOM6	hom	Verified	1.93006614535808	0.0267993212733034	no	255	0.0241599996810145	167	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex	mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial matrix	protein channel activity	mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YNL022C_p	YNL022C	YNL022C	hom	Uncharacterized	1.92785694563572	0.0269364611373431	no	256	0.0206856305158202	136	NA	FT		NUCLEUS		Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis	biological_process	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YMR216C	YMR216C	SKY1	hom	Verified	1.92545917543648	0.0270859692977759	no	257	0.0734644616287388	361	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS			SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1	cellular cation homeostasis|cellular ion homeostasis|response to drug|protein phosphorylation|positive regulation of protein import into nucleus|regulation of cell size|mRNA splice site selection	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YDL024C	YDL024C	DIA3	hom	Verified	1.92316480514216	0.0272296778700062	no	258	0.0426976697245819	213	NA					Protein of unknown function, involved in invasive and pseudohyphal growth	pseudohyphal growth|invasive growth in response to glucose limitation	acid phosphatase activity	fungal-type cell wall
YOL099C_d	YOL099C	YOL099C	hom	Dubious	1.91776060385443	0.027570686636322	no	259	0.0191265375485761	138	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes	Unknown	Unknown	Unknown
YMR082C_d	YMR082C	YMR082C	hom	Dubious	1.91678891407168	0.0276323769495933	no	260	0.0356924228564655	152	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL192C	YJL192C	SOP4	hom	Verified	1.9149068331455	0.0277521931185532	no	261	0.0516592203005319	286	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum
YLR399C	YLR399C	BDF1	hom	Verified	1.91104389837379	0.027999469885302	no	262	0.0275550911091485	219	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p	DNA repair|snRNA transcription|regulation of chromatin silencing at telomere|regulation of transcription by chromatin organization|regulation of chromatin silencing at silent mating-type cassette|Unknown|chromatin remodeling|negative regulation of heterochromatin assembly	histone acetyl-lysine binding|chromatin binding|core promoter binding|TFIID-class transcription factor binding	nuclear chromatin|Swr1 complex
YGL059W	YGL059W	PKP2	hom	Verified	1.90784987931768	0.0282053109161257	no	263	0.0276818548049805	150	NA	FT	CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization|negative regulation of catalytic activity	protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity	mitochondrion
YLR128W	YLR128W	DCN1	hom	Verified	1.90527518386954	0.0283721547727394	no	264	0.0363137533940504	166	NA					Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation	protein neddylation|positive regulation of ubiquitin-protein ligase activity	ubiquitin binding|NEDD8 ligase activity|small conjugating protein binding	cellular_component
YDR372C	YDR372C	VPS74	hom	Verified	1.9038516959164	0.0284647507949622	no	265	0.0453555323289165	239	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33	retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum unfolded protein response|protein localization to Golgi apparatus	enzyme binding|phosphatidylinositol-4-phosphate binding	cytosol|Golgi apparatus|nucleus|extrinsic to membrane|cytoplasm
YFR026C	YFR026C	ULI1	hom	Verified	1.90204487002639	0.0285826444126012	no	266	0.0280311727487839	122	NA	FT	SIGNALING			Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response	endoplasmic reticulum unfolded protein response	molecular_function	cellular_component
YOR035C	YOR035C	SHE4	hom	Verified	1.90089446499104	0.0286579186186377	no	267	0.0975665634569994	445	NA	FF|FT	CYTOSKELETON ORGANIZATION|RNA LOCALIZATION			Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization	mating type switching|intracellular mRNA localization|actin cytoskeleton organization	myosin binding	cytoplasm
YPL201C	YPL201C	YIG1	hom	Verified	1.89235295793981	0.0292219846668261	no	268	0.0310869545687806	190	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol	glycerol biosynthetic process	molecular_function	cytosol|nucleus
YOL093W	YOL093W	TRM10	hom	Verified	1.87958811077877	0.0300821174306817	no	269	0.0399598120240767	182	NA	FT	RNA PROCESSING	NUCLEUS		tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress	tRNA methylation	tRNA (guanine) methyltransferase activity	nucleus|cytoplasm
YDL019C	YDL019C	OSH2	hom	Verified	1.87810427819936	0.0301834505993635	no	270	0.0467013821922312	187	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	endocytosis|maintenance of cell polarity|sterol transport|exocytosis	lipid binding|oxysterol binding|sterol transporter activity|1-phosphatidylinositol binding	endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum|cellular bud neck
YFL014W	YFL014W	HSP12	hom	Verified	1.87490913588419	0.0304026125018399	no	271	0.0127697060204982	70	NA	FT	MEMBRANE ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|PLASMA MEMBRANE		Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension	cellular response to oxidative stress|cell adhesion|plasma membrane organization|cellular response to osmotic stress|cellular response to heat	lipid binding	cytosol|endosome|nucleus|plasma membrane|cytoplasm
YJR106W	YJR106W	ECM27	hom	Verified	1.87434320021323	0.0304415684035729	no	272	0.0189111195763699	116	NA	FT	CELL WALL ORG/BIOGENESIS			Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p	fungal-type cell wall organization	molecular_function	integral to membrane
YNL047C	YNL047C	SLM2	hom	Verified	1.87168476622425	0.0306251141649438	no	273	0.0193877715404587	119	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol binding	plasma membrane
YGL131C	YGL131C	SNT2	hom	Verified	1.87134337814653	0.0306487508251611	no	274	0.0236169504396313	137	NA	FT		NUCLEUS|CHROMOSOME		DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress	biological_process	DNA binding	nucleus|Snt2C complex|cytoplasm
YGR135W	YGR135W	PRE9	hom	Verified	1.87129235759016	0.0306522846287799	no	275	0.0316209583961133	186	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform	proteasomal ubiquitin-dependent protein catabolic process|proteasome core complex assembly|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YIR018W	YIR018W	YAP5	hom	Verified	1.86970114592203	0.0307626651568013	no	276	0.0239333735122683	142	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS|CHROMOSOME		Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication	negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to iron|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nuclear chromatin|nucleus
YBL029W_p	YBL029W	YBL029W	hom	Uncharacterized	1.8691008182031	0.0308043946100632	no	277	0.0375959745027359	184	NA	FT		NUCLEUS		Non-essential protein of unknown function	biological_process	molecular_function	nucleus|cytoplasm
YDR401W_d	YDR401W	YDR401W	hom	Dubious	1.86363897691378	0.0311862101073962	no	278	0.0355579228960543	126	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNR007C	YNR007C	ATG3	hom	Verified	1.86012174369373	0.0314341517589919	no	279	0.0300233104248982	195	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly	Atg8 ligase activity	cytosol|cytoplasm
YGL004C	YGL004C	RPN14	hom	Verified	1.85741130291889	0.0316263298063654	no	280	0.0370856408945529	126	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p	proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|cytoplasm
YJR148W	YJR148W	BAT2	hom	Verified	1.85524752520809	0.0317804439330696	no	281	0.0241311759522128	150	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase	branched-chain amino acid catabolic process|branched-chain amino acid biosynthetic process	branched-chain-amino-acid transaminase activity	nucleus|cytoplasm
YDR523C	YDR523C	SPS1	hom	Verified	1.85134503623682	0.0320599654535568	no	282	0.0110507072459993	79	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis	ascospore wall assembly|ascospore formation|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	nucleus|prospore membrane|cytoplasm
YDL186W_p	YDL186W	YDL186W	hom	Uncharacterized	1.84830273037412	0.0322792804892979	no	283	0.0281643554837314	127	NA					Putative protein of unknown function; YDL186W is not an essential gene	biological_process	molecular_function	cellular_component
YBR115C	YBR115C	LYS2	hom	Verified	1.84443722620662	0.0325597231582139	no	284	0.0240501276050133	144	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p	lysine biosynthetic process via aminoadipic acid	L-aminoadipate-semialdehyde dehydrogenase activity	cytoplasm
YDR230W_d	YDR230W	YDR230W	hom	Dubious	1.84125616340049	0.0327920142154657	no	285	0.018847699403603	114	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20	Unknown	Unknown	Unknown
YDL180W_p	YDL180W	YDL180W	hom	Uncharacterized	1.84091198760391	0.0328172287036046	no	286	0.0315021243319666	157	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YPL090C	YPL090C	RPS6A	hom	Verified	1.83901945380519	0.0329561623896614	no	287	0.034916575811342	212	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YPR188C	YPR188C	MLC2	hom	Verified	1.8379663485081	0.0330336820826641	no	288	0.0300353237671386	139	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring	actomyosin contractile ring contraction	myosin II binding	cellular bud neck contractile ring
YDR370C	YDR370C	DXO1	hom	Verified	1.83362385016742	0.0333549246893348	no	289	0.0293185181320853	166	NA					Protein with decapping and 5&#8242;-3&#8242; exoRNase activity; similar to Rai1p	biological_process	molecular_function	cytoplasm
YPL049C	YPL049C	DIG1	hom	Verified	1.82589703068009	0.033932886780062	no	290	0.046894632600988	262	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p	negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown	DNA binding|transcription factor binding	nucleus
YJR096W	YJR096W	YJR096W	hom	Verified	1.82495514984414	0.034003898867841	no	291	0.0270800881998377	162	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity	nucleus|cytoplasm
YGL101W_p	YGL101W	YGL101W	hom	Uncharacterized	1.82309555396807	0.0341444599344407	no	292	0.0363335996603142	131	NA	FT		NUCLEUS		Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p	biological_process	molecular_function	nucleus|cytoplasm
YGR069W_d	YGR069W	YGR069W	hom	Dubious	1.81994135220073	0.0343839683196558	no	293	0.04507230021937	210	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR313C	YDR313C	PIB1	hom	Verified	1.8168280725362	0.0346217214626875	no	294	0.0326231463968167	177	NA					RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain	protein ubiquitination	ubiquitin-protein ligase activity|phosphatidylinositol-3-phosphate binding	fungal-type vacuole membrane|late endosome
YEL016C	YEL016C	NPP2	hom	Verified	1.81429224578306	0.0348163723698439	no	295	0.0374646951365509	163	NA	FT	NUCLEOTIDE METABOLISM			Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication	nucleoside triphosphate metabolic process	nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity	cellular_component
YCL074W	YCL074W	YCL074W	hom	pseudogene	1.81352485436316	0.0348754543755444	no	296	0.0315173523503422	115	NA	FT		NUCLEUS		Pseudogene: encodes fragment of Ty Pol protein	transposition, RNA-mediated	ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity	retrotransposon nucleocapsid
YLR058C	YLR058C	SHM2	hom	Verified	1.81129933395244	0.0350472643726989	no	297	0.0318288729336723	156	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	SITE OF POLARIZED GROWTH		Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis	one-carbon metabolic process	glycine hydroxymethyltransferase activity	plasma membrane|mating projection tip|cytoplasm
YOL050C_d	YOL050C	YOL050C	hom	Dubious	1.80902193826727	0.0352237975832228	no	298	0.0470250655523308	248	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	Unknown	Unknown	Unknown
YOR359W	YOR359W	VTS1	hom	Verified	1.80563375869089	0.0354877829395	no	299	0.0467313126871944	228	NA	FT	PROTEIN LOCALIZATION|RNA PROCESSING	NUCLEUS		Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity	nuclear-transcribed mRNA catabolic process|positive regulation of endodeoxyribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening	flap-structured DNA binding|RNA binding	cytosol|nucleus|cytoplasmic mRNA processing body
YGR041W	YGR041W	BUD9	hom	Verified	1.80428128036941	0.0355936114329391	no	300	0.0194188058810304	81	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole	cellular bud site selection	molecular_function	plasma membrane|cellular bud neck
YML047C	YML047C	PRM6	hom	Verified	1.80419737857193	0.0356001850795997	no	301	0.0275937176395657	123	NA					Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family	biological_process	molecular_function	integral to membrane
YBL015W	YBL015W	ACH1	hom	Verified	1.80261708171355	0.035724186234059	no	302	0.0288333304069986	109	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth	acetate metabolic process	acetate CoA-transferase activity|acetyl-CoA hydrolase activity	cytosol|mitochondrion
YDR279W	YDR279W	RNH202	hom	Verified	1.80063661376264	0.0358800871450051	no	303	0.0257069226333395	136	NA	FT		NUCLEUS		Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome	RNA catabolic process|DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus
YJR117W	YJR117W	STE24	hom	Verified	1.79875831233788	0.0360284601588248	no	304	0.0257263653365964	140	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans	CAAX-box protein processing|peptide pheromone maturation	metalloendopeptidase activity	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|integral to membrane|nuclear inner membrane
YDR431W_d	YDR431W	YDR431W	hom	Dubious	1.79700528314809	0.0361673905200806	no	305	0.0212689958960687	135	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL131W_p	YOL131W	YOL131W	hom	Uncharacterized	1.79481097751909	0.0363419106059461	no	306	0.0353888386187786	200	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR008C-A_p	YOR008C-A	YOR008C-A	hom	Uncharacterized	1.79446047173734	0.0363698511824754	no	307	0.0266180500519982	132	NA					Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres	biological_process	molecular_function	cellular_component
YIL044C	YIL044C	AGE2	hom	Verified	1.79100736272603	0.0366460567462152	no	308	0.0385097062629855	221	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	GOLGI APPARATUS		ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport	ARF GTPase activator activity	clathrin-coated vesicle
YDR090C_p	YDR090C	YDR090C	hom	Uncharacterized	1.78708041085246	0.0369622465460358	no	309	0.0454434395055981	206	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YGR063C	YGR063C	SPT4	hom	Verified	1.78319968902273	0.0372769015439601	no	310	0.0775210340197598	334	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions	7-methylguanosine mRNA capping|chromosome segregation|chromatin organization|intracellular mRNA localization|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription, DNA-dependent|regulation of transcription-coupled nucleotide-excision repair|chromatin silencing|mRNA splicing, via spliceosome|Unknown	core RNA polymerase I binding transcription factor activity|core RNA polymerase II binding transcription factor activity|rDNA binding	DSIF complex|nuclear telomeric heterochromatin|rDNA heterochromatin|mating-type region heterochromatin|kinetochore
YMR081C	YMR081C	ISF1	hom	Verified	1.781549878392	0.0374113320752916	no	311	0.0281819900346149	174	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant	aerobic respiration	molecular_function	cellular_component
YGR137W_d	YGR137W	YGR137W	hom	Dubious	1.77614583892737	0.0378544412794264	no	312	0.032890244321589	181	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR184W_p	YBR184W	YBR184W	hom	Uncharacterized	1.77440240733838	0.0379983059774408	no	313	0.0368395413780646	181	NA					Putative protein of unknown function; YBR184W is not an essential gene	biological_process	molecular_function	cellular_component
YHR180W_d	YHR180W	YHR180W	hom	Dubious	1.77370841697518	0.0380556967355442	no	314	0.0302371370048653	170	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR026W	YPR026W	ATH1	hom	Verified	1.77175916809906	0.0382172716080407	no	315	0.0278059384837368	126	NA	FT	CARBOHYDRATE METABOLISM			Acid trehalase required for utilization of extracellular trehalose	trehalose catabolic process|response to stress	alpha,alpha-trehalase activity	fungal-type cell wall|cell wall-bounded periplasmic space|fungal-type vacuole
YBL060W	YBL060W	YEL1	hom	Verified	1.75546310612509	0.0395900629977216	no	316	0.04550151793045	236	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip	positive regulation of phosphatidylinositol biosynthetic process|protein localization|actin cortical patch localization	ARF guanyl-nucleotide exchange factor activity	cellular bud neck|cellular bud tip|cytoplasm
YMR002W	YMR002W	MIC17	hom	Verified	1.75472305067412	0.0396533456207959	no	317	0.0450414206935195	217	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	aerobic respiration	molecular_function	nucleus|cytoplasm|mitochondrial intermembrane space
YNL211C_p	YNL211C	YNL211C	hom	Uncharacterized	1.75117316377168	0.039958043292705	no	318	0.0359303938753893	208	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene	biological_process	molecular_function	mitochondrion
YFR020W_p	YFR020W	YFR020W	hom	Uncharacterized	1.75034158429514	0.0400296946939675	no	319	0.0437584806207816	221	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YNR025C_d	YNR025C	YNR025C	hom	Dubious	1.74862436413867	0.0401779859751589	no	320	0.0340044330557112	211	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase	Unknown	Unknown	Unknown
YML101C-A_d	YML101C-A	YML101C-A	hom	Dubious	1.74780837628132	0.0402486072017651	no	321	0.0320382200184612	163	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL181W	YKL181W	PRS1	hom	Verified	1.74548598840706	0.040450154670271	no	322	0.0396895751427281	250	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YDR222W_p	YDR222W	YDR222W	hom	Uncharacterized	1.74529807375415	0.0404664985366933	no	323	0.0579572142925694	245	NA	FT	RESPONSE TO OXIDATIVE STRESS			Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YGR201C_p	YGR201C	YGR201C	hom	Uncharacterized	1.74381926696383	0.0405953048713611	no	324	0.0275830755893043	160	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR100W	YMR100W	MUB1	hom	Verified	1.73728324256357	0.0411685939637975	no	325	0.0528309498198936	228	NA	FT	CELL DIVISION			MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene	regulation of cell budding|protein monoubiquitination	molecular_function	cellular_component
YDL197C	YDL197C	ASF2	hom	Verified	1.73569117779002	0.0413092271264167	no	326	0.0255442480013753	128	NA	FT	GENE SILENCING	NUCLEUS|CHROMOSOME		Anti-silencing protein that causes derepression of silent loci when overexpressed	chromatin silencing at silent mating-type cassette	molecular_function	nuclear chromosome, telomeric region|nucleus
YGL151W	YGL151W	NUT1	hom	Verified	1.73525346622396	0.0413479600338939	no	327	0.0367393682273328	185	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription	regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	molecular_function	mitochondrion|mediator complex|nucleus
YPL148C	YPL148C	PPT2	hom	Verified	1.73302516426224	0.0415455981025683	no	328	0.0856100624218415	362	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation	protein-cofactor linkage	holo-[acyl-carrier-protein] synthase activity	mitochondrion
YDL142C	YDL142C	CRD1	hom	Verified	1.7299157448704	0.0418226648939356	no	329	0.0370549829765682	184	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis	lipid biosynthetic process|cellular ion homeostasis|mitochondrial membrane organization	cardiolipin synthase activity	mitochondrion|integral to membrane
YMR173W	YMR173W	DDR48	hom	Verified	1.72654174331663	0.0421249981291297	no	330	0.029343701464011	115	NA	FT	RESPONSE TO DNA DAMAGE			DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress	DNA repair	ATPase activity|GTPase activity	cytoplasm
YPL125W	YPL125W	KAP120	hom	Verified	1.72549621301713	0.042219042838403	no	331	0.0494784008764385	232	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p	protein import into nucleus|transcription factor import into nucleus	protein transporter activity|structural constituent of nuclear pore	integral to membrane|nucleus|nuclear pore|cytoplasm
YDR099W	YDR099W	BMH2	hom	Verified	1.72498921941926	0.0422647076789836	no	332	0.0488951105784612	186	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	glycogen metabolic process|ascospore formation|Ras protein signal transduction|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|DNA damage checkpoint|DNA replication initiation|signal transduction involved in filamentous growth|pseudohyphal growth|fungal-type cell wall chitin biosynthetic process|pre-replicative complex assembly	DNA replication origin binding|phosphoserine binding	nucleus|plasma membrane
YDL050C_d	YDL050C	YDL050C	hom	Dubious	1.71602187977595	0.0430790189489637	no	333	0.0263031159151434	172	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR096W	YDR096W	GIS1	hom	Verified	1.71528665892771	0.0431463416608804	no	334	0.0378825928160897	157	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|MITOCHONDRION		Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|chronological cell aging|regulation of phospholipid biosynthetic process|histone demethylation|positive regulation of transcription from RNA polymerase II promoter|maintenance of stationary phase in response to starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|histone demethylase activity (H3-K36 specific)	mitochondrion|nucleus
YGL205W	YGL205W	POX1	hom	Verified	1.71523436682843	0.0431511331797247	no	335	0.0247610476621519	139	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix	fatty acid beta-oxidation using acyl-CoA oxidase|fatty acid beta-oxidation	acyl-CoA oxidase activity	peroxisomal matrix
YCL038C	YCL038C	ATG22	hom	Verified	1.71383844003811	0.0432792007380906	no	336	0.0368367912655488	177	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT			Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation	amino acid export from vacuole	molecular_function	integral to fungal-type vacuolar membrane|integral to membrane
YGL079W_p	YGL079W	KXD1	hom	Uncharacterized	1.71148765847717	0.0434955637662329	no	337	0.0342116522048699	189	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YJL128C	YJL128C	PBS2	hom	Verified	1.71111819255026	0.0435296482121382	no	338	0.0648149533761802	359	NA	FF|FT	PROTEIN LOCALIZATION|SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition	activation of MAPK activity involved in osmosensory signaling pathway|actin filament organization|MAPK import into nucleus involved in osmosensory signaling pathway|protein phosphorylation|hyperosmotic response|osmosensory signaling pathway|cellular response to heat	MAP-kinase scaffold activity|MAP kinase kinase activity|protein kinase activity	cellular bud neck|cytoplasm|cellular bud tip
YLL007C_p	YLL007C	YLL007C	hom	Uncharacterized	1.70894113524708	0.0437309269099708	no	339	0.0758199976397662	318	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene	biological_process	molecular_function	cytoplasm
YIL092W_p	YIL092W	YIL092W	hom	Uncharacterized	1.70846230341267	0.0437752976463547	no	340	0.0401359276564966	183	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YGL066W	YGL066W	SGF73	hom	Verified	1.70458499538955	0.0441359258659228	no	341	0.0638642945789803	251	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RNA LOCALIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay	histone deubiquitination|mRNA export from nucleus|histone acetylation|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|protein complex assembly|chromatin modification	histone acetyltransferase activity|enzyme activator activity|structural molecule activity	DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YKR029C	YKR029C	SET3	hom	Verified	1.7043751667529	0.044155510131723	no	342	0.0475779956191364	256	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication	negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation	methylated histone residue binding	Rpd3L-Expanded complex|Set3 complex
YFR023W	YFR023W	PES4	hom	Verified	1.70258976243394	0.0443224336350549	no	343	0.0517641858966591	218	NA	FT		NUCLEUS		Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YGL037C	YGL037C	PNC1	hom	Verified	1.70255484313512	0.0443257034222179	no	344	0.0292570722849663	132	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING	NUCLEUS		Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress	replicative cell aging|chromatin silencing at rDNA|nicotinate nucleotide salvage|chromatin silencing at telomere	nicotinamidase activity	nucleus|peroxisome|cytoplasm
YGR171C	YGR171C	MSM1	hom	Verified	1.70161876417718	0.0444134288345871	no	345	0.0508870699327501	242	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p	methionyl-tRNA aminoacylation	methionine-tRNA ligase activity	mitochondrion
YNR062C_p	YNR062C	YNR062C	hom	Uncharacterized	1.69236873379648	0.0452878449712822	no	346	0.0433370483932192	214	NA					Putative membrane protein of unknown function	biological_process	molecular_function	integral to membrane
YLR098C	YLR098C	CHA4	hom	Verified	1.69110924546039	0.0454079698695442	no	347	0.0475644146030051	187	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain	positive regulation of transcription, DNA-dependent|cellular amino acid catabolic process	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YPR173C	YPR173C	VPS4	hom	Verified	1.68861375475193	0.0456467365085505	no	348	0.0724395950857951	345	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism	late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport	ATPase activity|protein homodimerization activity|ATP binding	endosome|endoplasmic reticulum|membrane|cytoplasm
YDR185C	YDR185C	UPS3	hom	Verified	1.68824323918643	0.045682273051244	no	349	0.0458777482416853	197	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations	mitochondrion morphogenesis	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YBR085W	YBR085W	AAC3	hom	Verified	1.68793989415076	0.0457113837509585	no	350	0.0346286289820946	192	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication	heme biosynthetic process|heme transport|anaerobic respiration|transmembrane transport	ATP:ADP antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YNL162W-A_p	YNL162W-A	YNL162W-A	hom	Uncharacterized	1.68771854194369	0.0457326353653963	no	351	0.0391884197409849	222	NA	FT		NUCLEUS		Putative protein of unknown function; identified by homology	biological_process	molecular_function	nucleus|cytoplasm
YOR118W	YOR118W	RTC5	hom	Verified	1.67997528913652	0.0464810618424959	no	352	0.0646241356189618	236	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity	biological_process	molecular_function	cytoplasm
YKR050W	YKR050W	TRK2	hom	Verified	1.67894933507389	0.0465809591735594	no	353	0.053882986354744	180	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication	cellular potassium ion homeostasis	potassium ion transmembrane transporter activity	integral to membrane|plasma membrane
YGR237C_p	YGR237C	YGR237C	hom	Uncharacterized	1.67808186404235	0.0466655593483774	no	354	0.0430956524927621	236	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YNL056W	YNL056W	OCA2	hom	Verified	1.67638145306108	0.0468317497155549	no	355	0.0449214804652907	210	NA					Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene	biological_process	molecular_function	cytoplasm
YBR158W	YBR158W	AMN1	hom	Verified	1.67555331579295	0.0469128597842533	no	356	0.0508591812865615	248	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS		Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)	mitotic cell cycle checkpoint|negative regulation of exit from mitosis	protein binding	nucleus|cellular bud|cytoplasm
YMR160W	YMR160W	YMR160W	hom	Verified	1.67553170728909	0.0469149776885229	no	357	0.048386519705615	236	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress	biological_process	molecular_function	fungal-type vacuole membrane
YDL086W_p	YDL086W	YDL086W	hom	Uncharacterized	1.66886677660444	0.0475718925818062	no	358	0.0219152207092395	133	NA	FT		MITOCHONDRION		Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene	biological_process	carboxymethylenebutenolidase activity	mitochondrion|cytoplasm
YER026C	YER026C	CHO1	hom	Verified	1.66515804861954	0.0479406140499061	no	359	0.057323161186337	264	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM|MITOCHONDRION		Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline	phosphatidylserine biosynthetic process	CDP-diacylglycerol-serine O-phosphatidyltransferase activity	mitochondrial outer membrane|integral to membrane|endoplasmic reticulum
YLR210W	YLR210W	CLB4	hom	Verified	1.66244246342185	0.0482120453626738	no	360	0.0480501538523453	191	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|CYTOSKELETON		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation	G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|spindle pole body|cytoplasm
YLR387C	YLR387C	REH1	hom	Verified	1.65979395388171	0.0484779552421754	no	361	0.0656930800298715	235	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS		RIBOSOME	Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains	ribosomal large subunit biogenesis|budding cell bud growth	molecular_function	cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YGR234W	YGR234W	YHB1	hom	Verified	1.65943295462943	0.0485142901509951	no	362	0.0317396766199103	173	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	response to stress	nitric oxide reductase activity	cytosol|mitochondrion|mitochondrial matrix|cytoplasm
YDR503C	YDR503C	LPP1	hom	Verified	1.65773242010247	0.0486857435185953	no	363	0.033999394887265	178	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA	phospholipid metabolic process	phosphatidate phosphatase activity	integral to membrane|membrane
YHR181W	YHR181W	SVP26	hom	Verified	1.65754949658832	0.0487042152735439	no	364	0.0532392889331757	230	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment	protein retention in Golgi apparatus|fungal-type cell wall organization|protein glycosylation|ER to Golgi vesicle-mediated transport	COPII adaptor activity	integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum|integral to Golgi membrane|ER to Golgi transport vesicle
YJR128W_d	YJR128W	YJR128W	hom	Dubious	1.65575916818138	0.0488852998618574	no	365	0.0423592842075018	136	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2	Unknown	Unknown	Unknown
YCL021W-A_p	YCL021W-A	YCL021W-A	hom	Uncharacterized	1.65522064635868	0.0489398743264575	no	366	0.0331815976046471	160	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPR130C_d	YPR130C	YPR130C	hom	Dubious	1.65360425646929	0.0491039736464729	no	367	0.0525677993399713	266	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL299W	YNL299W	TRF5	hom	Verified	1.65255248633526	0.0492109873997296	no	368	0.0598890684567434	258	NA	FT	CELL CYCLE|RNA PROCESSING|CELL DIVISION	NUCLEUS		Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p	nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation	polynucleotide adenylyltransferase activity	nucleolus|TRAMP complex
YJR077C	YJR077C	MIR1	hom	Verified	1.65159621943157	0.0493084456185267	no	369	0.0466432429860241	237	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated	phosphate ion transmembrane transport	inorganic phosphate transmembrane transporter activity	mitochondrion|integral to membrane|integral to mitochondrial inner membrane
YER188W_d	YER188W	YER188W	hom	Dubious	1.6467500042987	0.0498047207470627	no	370	0.0662489351585573	277	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p	Unknown	Unknown	Unknown
YDR132C	YDR132C	YDR132C	hom	Verified	1.64658422545022	0.0498217675016222	no	371	0.042158704759451	173	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YMR114C	YMR114C	YMR114C	hom	Verified	1.64473163254543	0.0500125832336104	no	372	0.0441913121278928	178	NA	FT		NUCLEUS		Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YLR006C	YLR006C	SSK1	hom	Verified	1.6444267553187	0.0500440411376093	no	373	0.0466247816007677	209	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate	activation of MAPKKK activity involved in osmosensory signaling pathway|positive regulation of protein autophosphorylation|osmosensory signaling pathway via two-component system	protein kinase activator activity|two-component response regulator activity|protein homodimerization activity|mitogen-activated protein kinase kinase kinase binding	cytoplasm
YLR047C	YLR047C	FRE8	hom	Verified	1.64114096275289	0.0503840786687314	no	374	0.0635941339159517	268	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p	cellular metal ion homeostasis	oxidoreductase activity, oxidizing metal ions	integral to membrane|membrane
YBR071W	YBR071W	YBR071W	hom	Verified	1.63989347541632	0.0505136588538897	no	375	0.0402065816228627	192	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking	biological_process	molecular_function	cellular bud neck|cytoplasm
YFR057W_p	YFR057W	YFR057W	hom	Uncharacterized	1.63836910148448	0.0506723603425717	no	376	0.0593726487301028	220	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPR116W	YPR116W	RRG8	hom	Verified	1.63745986473993	0.0507672092429545	no	377	0.0527839940367152	235	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport	mitochondrial genome maintenance	molecular_function	mitochondrion
YOR155C	YOR155C	ISN1	hom	Verified	1.63703369662097	0.0508117144806361	no	378	0.0473651309481455	151	NA	FT	NUCLEOTIDE METABOLISM			Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms	nicotinamide riboside biosynthetic process|inosine salvage|nicotinic acid riboside biosynthetic process	IMP 5'-nucleotidase activity	cellular_component
YDR271C_d	YDR271C	YDR271C	hom	Dubious	1.63629184314412	0.0508892612125632	no	379	0.0794532302591914	365	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W	Unknown	Unknown	Unknown
YGL152C_d	YGL152C	YGL152C	hom	Dubious	1.63263265062939	0.0512731399668653	no	380	0.060185494811442	170	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W	Unknown	Unknown	Unknown
YER049W	YER049W	TPA1	hom	Verified	1.63057415393151	0.0514901032563101	no	381	0.0343038028315225	164	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS	NUCLEUS		Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|translational termination	poly(A) RNA binding	nucleus
YEL052W	YEL052W	AFG1	hom	Verified	1.62945985997343	0.0516078528277024	no	382	0.0410744997306766	184	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|RESPONSE TO OXIDATIVE STRESS|PEROXISOME ORGANIZATION	MITOCHONDRION		Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain	protein import into peroxisome matrix|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process	molecular_function	mitochondrion|mitochondrial inner membrane
YLR091W	YLR091W	GEP5	hom	Verified	1.62749231522109	0.0518162897105266	no	383	0.0695960822364111	284	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine	mitochondrial genome maintenance	molecular_function	mitochondrion
YKL102C_d	YKL102C	YKL102C	hom	Dubious	1.62465727184813	0.0521178032479688	no	384	0.0453287040175685	178	NA					Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site	Unknown	Unknown	Unknown
YBL017C	YBL017C	PEP1	hom	Verified	1.62414566007274	0.0521723625111987	no	385	0.0315652855096914	129	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments	vacuolar transport|protein targeting to vacuole	signal sequence binding	integral to membrane|Golgi apparatus
YPR158W	YPR158W	CUR1	hom	Verified	1.61973681394531	0.0526444122620866	no	386	0.0622838450976783	333	NA	FT		NUCLEUS		Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication	cellular response to stress|protein localization to nucleus	chaperone binding	nucleus
YGR229C	YGR229C	SMI1	hom	Verified	1.61969600287927	0.0526487976325919	no	387	0.0752002865472378	372	NA	FF|FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	NUCLEUS|SITE OF POLARIZED GROWTH		Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity	regulation of mitotic cell cycle|regulation of fungal-type cell wall biogenesis	molecular_function	incipient cellular bud site|cellular bud neck|mating projection tip
YJR109C	YJR109C	CPA2	hom	Verified	1.61730139979918	0.0529066186461239	no	388	0.0372298204353968	174	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor	arginine biosynthetic process	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carbamoyl-phosphate synthase complex
YGL176C_p	YGL176C	YGL176C	hom	Uncharacterized	1.61655087770343	0.0529876313133218	no	389	0.0601577528943828	253	NA					Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype	biological_process	molecular_function	cellular_component
YGR033C	YGR033C	TIM21	hom	Verified	1.61494726761674	0.0531610574489087	no	390	0.0446918758286341	210	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity	protein import into mitochondrial matrix	molecular_function	mitochondrion|mitochondrial inner membrane presequence translocase complex
YKL015W	YKL015W	PUT3	hom	Verified	1.61191227525154	0.0534905153093352	no	391	0.0377799003302842	183	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDL052C	YDL052C	SLC1	hom	Verified	1.60667718158236	0.054062600855723	no	392	0.0710826568283308	299	NA	FT	LIPID METABOLISM			1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes	glycerophospholipid biosynthetic process	1-acylglycerol-3-phosphate O-acyltransferase activity	lipid particle
YPL195W	YPL195W	APL5	hom	Verified	1.60396964923763	0.0543603714105276	no	393	0.0777717782543756	342	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function	vesicle-mediated transport|Golgi to vacuole transport	protein binding	AP-3 adaptor complex
YBR090C_p	YBR090C	YBR090C	hom	Uncharacterized	1.60381927121292	0.054376947728309	no	394	0.0391060494942098	177	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YBL024W	YBL024W	NCL1	hom	Verified	1.60318841676162	0.0544465310130258	no	395	0.0846673246093777	302	NA	FT	RNA PROCESSING	NUCLEUS		S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120	tRNA methylation	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YLR349W_d	YLR349W	YLR349W	hom	Dubious	1.60295400600186	0.0544724044741425	no	396	0.0463409686346729	183	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C	Unknown	Unknown	Unknown
YLR184W_d	YLR184W	YLR184W	hom	Dubious	1.60120236609039	0.0546660524842847	no	397	0.0514410831433935	278	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR262W_p	YDR262W	YDR262W	hom	Uncharacterized	1.59867874040436	0.0549460018932344	no	398	0.0342838845020726	183	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment	biological_process	molecular_function	fungal-type vacuole
YNL201C	YNL201C	PSY2	hom	Verified	1.59528363570124	0.0553244116548043	no	399	0.0673744281688698	293	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3	Unknown|response to DNA damage stimulus|protein dephosphorylation|signal transduction involved in meiotic recombination checkpoint	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus
YLR053C_p	YLR053C	YLR053C	hom	Uncharacterized	1.59453696777945	0.0554079088135685	no	400	0.0385281984920141	201	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL013C_d	YNL013C	YNL013C	hom	Dubious	1.59408605481264	0.0554583809396422	no	401	0.0367272965385611	172	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W	Unknown	Unknown	Unknown
YHR093W_d	YHR093W	AHT1	hom	Dubious	1.58897257451328	0.0560332923067688	no	402	0.0522309981667087	218	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region	Unknown	Unknown	Unknown
YDR310C	YDR310C	SUM1	hom	Verified	1.58869331014711	0.0560648250128229	no	403	0.0672039959501397	278	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS		Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint	negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter during mitosis|DNA replication initiation|chromatin silencing at silent mating-type cassette	DNA replication origin binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus
YDR426C_d	YDR426C	YDR426C	hom	Dubious	1.58821011342073	0.0561194174812864	no	404	0.030137933239798	154	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41	Unknown	Unknown	Unknown
YOR016C	YOR016C	ERP4	hom	Verified	1.58762015430579	0.0561861289905329	no	405	0.0443533636940503	169	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane
YPR149W	YPR149W	NCE102	hom	Verified	1.58581563706175	0.0563905687204148	no	406	0.0452113390447236	245	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)	eisosome assembly|protein secretion|negative regulation of protein phosphorylation|plasma membrane organization|establishment of protein localization to plasma membrane	molecular_function	mitochondrion|integral to membrane|membrane raft|endoplasmic reticulum|cellular bud membrane|plasma membrane|mating projection membrane|cytoplasm
YDL137W	YDL137W	ARF2	hom	Verified	1.58278665054599	0.0567350502060232	no	407	0.0613744626639918	283	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport	GTPase activity	cytosol|Golgi-associated vesicle
YGL214W_d	YGL214W	YGL214W	hom	Dubious	1.58084654028888	0.0569565651192639	no	408	0.0525197356966159	228	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C	Unknown	Unknown	Unknown
YBR051W_d	YBR051W	YBR051W	hom	Dubious	1.58066811504322	0.0569769712284508	no	409	0.0561885584204839	250	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase	Unknown	Unknown	Unknown
YKL170W	YKL170W	MRPL38	hom	Verified	1.5779713354329	0.0572860975885068	no	410	0.0695216654509753	305	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDR206W	YDR206W	EBS1	hom	Verified	1.57760291026811	0.057328431691691	no	411	0.0614409508780105	178	NA	FT	TRANSLATION	NUCLEUS|CHROMOSOME		Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors	negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YDR246W-A_p	YDR246W-A	YDR246W-A	hom	Uncharacterized	1.57756989347963	0.0573322267061201	no	412	0.046499282087115	249	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YPR062W	YPR062W	FCY1	hom	Verified	1.57511111594681	0.0576153993370529	no	413	0.0724675353883048	336	NA	FT		NUCLEUS		Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)	cytosine metabolic process|pyrimidine-containing compound salvage|cytidine metabolic process	cytosine deaminase activity	nucleus|cytoplasm
YJR099W	YJR099W	YUH1	hom	Verified	1.5746999933177	0.0576628546867164	no	414	0.042746965755912	164	NA	FT	PROTEOLYSIS			Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p	protein deubiquitination	ubiquitin-specific protease activity	cytoplasm
YDR320C	YDR320C	SWA2	hom	Verified	1.5741968149865	0.0577209777321377	no	415	0.112410600599751	439	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles	positive regulation of ATPase activity|endoplasmic reticulum inheritance|clathrin coat disassembly	ubiquitin binding|clathrin binding	endoplasmic reticulum membrane
YBR061C	YBR061C	TRM7	hom	Verified	1.57307358762964	0.0578508899610428	no	416	0.0556981513045941	295	NA	FT	RNA PROCESSING|TRANSLATION			2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively	cytoplasmic translation|tRNA methylation	tRNA methyltransferase activity	cytoplasm
YER011W	YER011W	TIR1	hom	Verified	1.57191931209893	0.0579846325782965	no	417	0.0430913108559896	214	NA					Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking	response to stress	structural constituent of cell wall	fungal-type cell wall
YIL005W	YIL005W	EPS1	hom	Verified	1.56583262842087	0.0586939027243068	no	418	0.0567416227424473	316	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family	protein retention in ER lumen|ER-associated protein catabolic process	unfolded protein binding|protein disulfide isomerase activity|chaperone binding	endoplasmic reticulum membrane
YIL102C_p	YIL102C	YIL102C	hom	Uncharacterized	1.56165481874859	0.0591846639403017	no	419	0.0504847332739279	219	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YFL046W_p	YFL046W	FMP32	hom	Uncharacterized	1.55984095284389	0.0593987355080069	no	420	0.0503662899843398	205	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YJL108C	YJL108C	PRM10	hom	Verified	1.55568054724289	0.0598920372636625	no	421	0.0703675097350048	272	NA					Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	integral to membrane
YML074C	YML074C	FPR3	hom	Verified	1.55297170674947	0.0602149470565669	no	422	0.0470960878426865	182	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS		Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p	meiotic recombination checkpoint	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	nucleolus
YIL057C	YIL057C	RGI2	hom	Verified	1.55222081631498	0.0603046984607346	no	423	0.0720838570114286	310	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose	energy reserve metabolic process	molecular_function	cytoplasm
YHR110W	YHR110W	ERP5	hom	Verified	1.55102661875462	0.0604476525051985	no	424	0.053407454862905	250	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YDR199W_d	YDR199W	YDR199W	hom	Dubious	1.54913324329638	0.0606748464992597	no	425	0.0773905895677166	310	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity	Unknown	Unknown	Unknown
YDR253C	YDR253C	MET32	hom	Verified	1.54784554362951	0.0608297441473836	no	426	0.0755560551399106	342	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication	regulation of mitotic cell cycle|regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YGR081C	YGR081C	SLX9	hom	Verified	1.54494334839837	0.0611799834944826	no	427	0.0791457730693283	325	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	preribosome, small subunit precursor|nucleolus|nucleus|90S preribosome
YJR121W	YJR121W	ATP2	hom	Verified	1.54494204393826	0.0611801412713839	no	428	0.0569845453394012	254	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|mitochondrial proton-transporting ATP synthase, catalytic core|integral to membrane
YDR318W	YDR318W	MCM21	hom	Verified	1.54489971397615	0.0611852613324461	no	429	0.0834549316877856	369	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	COMA complex|condensed nuclear chromosome kinetochore
YDR475C	YDR475C	JIP4	hom	Verified	1.54323761816274	0.0613865665449615	no	430	0.0574657179046393	256	NA					Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence	biological_process	molecular_function	cellular_component
YMR171C	YMR171C	EAR1	hom	Verified	1.54087217795865	0.0616739491797701	no	431	0.0580454976567964	270	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT			Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	molecular_function	endosome
YKL106C-A_p	YKL106C-A	YKL106C-A	hom	Uncharacterized	1.53531418954617	0.0623533351662398	no	432	0.0379956602833002	160	NA					Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi	biological_process	molecular_function	cellular_component
YFR056C_d	YFR056C	YFR056C	hom	Dubious	1.53523091220875	0.0623635588505194	no	433	0.0559965906962348	246	NA					Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W	Unknown	Unknown	Unknown
YLR172C	YLR172C	DPH5	hom	Verified	1.53401297399174	0.0625132305190377	no	434	0.068705311861289	321	NA					Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	diphthine synthase activity	cytoplasm
YBR249C	YBR249C	ARO4	hom	Verified	1.53154896736569	0.0628168870012979	no	435	0.0597244263214448	265	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress	aromatic amino acid family biosynthetic process	3-deoxy-7-phosphoheptulonate synthase activity	nucleus|cytoplasm
YDR095C_d	YDR095C	YDR095C	hom	Dubious	1.53100033727926	0.0628846546465536	no	436	0.0660277986511211	228	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR307W	YLR307W	CDA1	hom	Verified	1.52936383893203	0.0630871358559439	no	437	0.0398606174987848	178	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall	ascospore wall assembly	chitin deacetylase activity	chitosan layer of spore wall
YHL033C	YHL033C	RPL8A	hom	Verified	1.52877017404142	0.0631607144052952	no	438	0.0700912420686291	295	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR469W	YDR469W	SDC1	hom	Verified	1.52675404094527	0.0634110919133477	no	439	0.086697531356942	345	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30	histone H3-K4 methylation|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YGR028W	YGR028W	MSP1	hom	Verified	1.52551745863716	0.0635650411688249	no	440	0.0491221517984195	211	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase	protein targeting to mitochondrion	ATPase activity	mitochondrial outer membrane|mitochondrion
YOL083W	YOL083W	ATG34	hom	Verified	1.52502252544397	0.063626739692072	no	441	0.0469027500000102	186	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS			Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog	protein complex assembly|protein complex localization	protein binding, bridging	CVT complex
YDL123W	YDL123W	SNA4	hom	Verified	1.52480637068467	0.0636537002252317	no	442	0.0740228960445921	217	NA					Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated	biological_process	molecular_function	fungal-type vacuole lumen|fungal-type vacuole membrane
YKL003C	YKL003C	MRP17	hom	Verified	1.52454148275681	0.0636867512641999	no	443	0.0711882508117249	280	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YKL071W_p	YKL071W	YKL071W	hom	Uncharacterized	1.5241790566804	0.0637319941249608	no	444	0.0679134800978067	261	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	integral to membrane|cytoplasm
YBR130C	YBR130C	SHE3	hom	Verified	1.52230304685883	0.0639665824980544	no	445	0.0670306496110233	259	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance	mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization	mRNA binding	actin cap|cytoplasm|cellular bud tip
YLR257W	YLR257W	YLR257W	hom	Verified	1.52206512329449	0.0639963819123652	no	446	0.0599677910990219	275	NA					Protein of unknown function; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cytoplasm
YKL149C	YKL149C	DBR1	hom	Verified	1.51874501966875	0.0644133449389157	no	447	0.0608110592771255	269	NA	FT	RNA PROCESSING	NUCLEUS		RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition	snoRNA metabolic process|pseudohyphal growth|RNA catabolic process|transposition, RNA-mediated	RNA lariat debranching enzyme activity	nucleus
YGR181W	YGR181W	TIM13	hom	Verified	1.51651121267458	0.0646950686293422	no	448	0.0390775074278668	210	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane	protein import into mitochondrial inner membrane	protein transporter activity	mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex|mitochondrial intermembrane space
YLR114C	YLR114C	AVL9	hom	Verified	1.51549125817316	0.0648240212363081	no	449	0.0730943854280362	258	NA	FT	VESICLE-MEDIATED TRANSPORT			Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress	post-Golgi vesicle-mediated transport	molecular_function	cytoplasm
YGL139W	YGL139W	FLC3	hom	Verified	1.51298127914887	0.0651422071170849	no	450	0.0511070839087381	184	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER	FAD transport|transmembrane transport	FAD transmembrane transporter activity	mitochondrion|integral to membrane|endoplasmic reticulum
YGL082W_p	YGL082W	YGL082W	hom	Uncharacterized	1.51266998341076	0.0651817538926733	no	451	0.0442799345281811	216	NA	FT		NUCLEUS		Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene	biological_process	molecular_function	nucleus|plasma membrane|cytoplasm
YPL168W_p	YPL168W	YPL168W	hom	Uncharacterized	1.51204019865069	0.0652618182387792	no	452	0.0710202020661907	285	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated	biological_process	molecular_function	mitochondrion
YMR138W	YMR138W	CIN4	hom	Verified	1.51111383884415	0.0653797247096093	no	453	0.0748772465694394	338	NA	FT	SIGNALING			GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog	protein folding|tubulin complex assembly|tubulin complex biogenesis	GTP binding	cytoplasm
YLR364W	YLR364W	GRX8	hom	Verified	1.50929621177188	0.0656115511886823	no	454	0.044111746944567	197	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic	biological_process	glutathione-disulfide reductase activity	cytoplasm
YJL206C_p	YJL206C	YJL206C	hom	Uncharacterized	1.50855611763478	0.0657061277615301	no	455	0.058906268536174	281	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment	biological_process	molecular_function	cellular_component
YDR214W	YDR214W	AHA1	hom	Verified	1.5079705674138	0.0657810300380127	no	456	0.074325599626063	310	NA	FT	NUCLEOTIDE METABOLISM			Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress	protein folding|response to stress	ATPase activator activity|chaperone binding	cytoplasm
YCL055W	YCL055W	KAR4	hom	Verified	1.50775941191755	0.0658080568082957	no	457	0.0572795201529672	287	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone	karyogamy involved in conjugation with cellular fusion|meiosis|negative regulation of transcription from RNA polymerase II promoter by pheromones|positive regulation of transcription from RNA polymerase II promoter by pheromones|G1 phase of mitotic cell cycle	sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YBR183W	YBR183W	YPC1	hom	Verified	1.506771536536	0.0659346138933166	no	458	0.0732996951797485	286	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication	ceramide catabolic process|ceramide biosynthetic process	phytoceramidase activity|sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YML016C	YML016C	PPZ1	hom	Verified	1.50621435285322	0.0660060780446619	no	459	0.0822175265077894	287	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular sodium ion homeostasis|cellular protein localization|protein dephosphorylation	protein serine/threonine phosphatase activity	extrinsic to plasma membrane|nucleus|cytoplasm
YCL014W	YCL014W	BUD3	hom	Verified	1.50593433045788	0.066042016255312	no	460	0.0618189549819151	260	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding	cellular bud site selection|axial cellular bud site selection|cytokinesis	molecular_function	cellular bud neck contractile ring|cellular bud neck
YDL034W_d	YDL034W	YDL034W	hom	Dubious	1.50393427866138	0.0662991448696345	no	461	0.0589875228588106	263	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene	Unknown	Unknown	Unknown
YPL033C	YPL033C	SRL4	hom	Verified	1.50386454766836	0.0663081235204393	no	462	0.0505114560944146	200	NA	FT	NUCLEOTIDE METABOLISM			Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p	deoxyribonucleoside triphosphate metabolic process	molecular_function	cellular_component
YJR125C	YJR125C	ENT3	hom	Verified	1.5032153179481	0.0663917643621976	no	463	0.067248399421575	271	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|CYTOSKELETON		Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p	late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|actin filament organization|endocytosis|actin cortical patch assembly|Golgi to endosome transport	protein binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding	clathrin vesicle coat|actin cortical patch
YPL219W	YPL219W	PCL8	hom	Verified	1.50064874201478	0.0667232186377116	no	464	0.0816385622649027	310	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation	negative regulation of glycogen biosynthetic process	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YOL160W_d	YOL160W	YOL160W	hom	Dubious	1.50006672343704	0.0667985598421705	no	465	0.0394119560742932	142	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL067C_p	YEL067C	YEL067C	hom	Uncharacterized	1.49961647316419	0.0668568890323599	no	466	0.0698528048596811	279	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YMR109W	YMR109W	MYO5	hom	Verified	1.49186831692498	0.0678668349837227	no	467	0.0540004825352002	245	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization	bipolar cellular bud site selection|endocytosis|exocytosis|fungal-type cell wall organization|response to salt stress|receptor-mediated endocytosis|actin cortical patch localization|response to osmotic stress	microfilament motor activity	mating projection tip|actin cortical patch
YKL050C	YKL050C	YKL050C	hom	Verified	1.49175448526862	0.0678817598917612	no	468	0.0365139261352981	165	NA					Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p	biological_process	molecular_function	cellular_component
YIL110W	YIL110W	HPM1	hom	Verified	1.4908173846009	0.0680047231201366	no	469	0.0752659006161313	295	NA	FT		NUCLEUS		AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance	peptidyl-histidine methylation, to form tele-methylhistidine	S-adenosylmethionine-dependent methyltransferase activity|protein-histidine N-methyltransferase activity	nucleus|cytoplasm
YLR220W	YLR220W	CCC1	hom	Verified	1.4852296832602	0.0687414957228107	no	470	0.0611098209358803	282	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress	manganese ion transport|cellular calcium ion homeostasis|cellular iron ion homeostasis|cellular manganese ion homeostasis|ferrous iron transport	manganese ion transmembrane transporter activity|ferrous iron transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|Golgi apparatus
YBR233W	YBR233W	PBP2	hom	Verified	1.48492351626659	0.0687820428893243	no	471	0.0721390452480903	262	NA	FT		NUCLEUS		RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress	telomere maintenance via telomere shortening	mRNA binding	cytoplasm
YLL054C_p	YLL054C	YLL054C	hom	Uncharacterized	1.48482756340381	0.0687947541827073	no	472	0.0747076219823668	258	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene	biological_process	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	cellular_component
YIL016W	YIL016W	SNL1	hom	Verified	1.48400947379136	0.0689032036377668	no	473	0.0612528728935742	323	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein	protein folding|nuclear pore organization	ribosome binding	nuclear envelope|mitochondrion|cytosolic ribosome|endoplasmic reticulum membrane|membrane
YJL205C	YJL205C	NCE101	hom	Verified	1.48072669801282	0.0693397082976784	no	474	0.0581280449866907	277	NA	FT	PROTEIN LOCALIZATION			Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences	protein secretion	molecular_function	cellular_component
YNL005C	YNL005C	MRP7	hom	Verified	1.48049286600929	0.0693708815905367	no	475	0.124117739403478	417	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome|peptidyltransferase activity	mitochondrion|mitochondrial large ribosomal subunit
YHR138C	YHR138C	YHR138C	hom	Verified	1.47816741010826	0.0696814872995527	no	476	0.0668770924500511	257	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress	vacuole fusion, non-autophagic	endopeptidase inhibitor activity	cellular_component
YLR188W	YLR188W	MDL1	hom	Verified	1.47767057723862	0.0697479866974995	no	477	0.0756840316396148	305	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress	oligopeptide transport|oligopeptide export from mitochondrion	ATPase activity|oligopeptide-transporting ATPase activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDR428C	YDR428C	BNA7	hom	Verified	1.46921466410852	0.0708872870552586	no	478	0.0522424711219835	251	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine	NAD biosynthetic process	arylformamidase activity	cellular_component
YDR509W_d	YDR509W	YDR509W	hom	Dubious	1.46581343328266	0.0713495601977925	no	479	0.0747168927318048	348	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL135W_d	YJL135W	YJL135W	hom	Dubious	1.46290122009674	0.0717472050584961	no	480	0.0528623145316429	229	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3	Unknown	Unknown	Unknown
YLR179C	YLR179C	YLR179C	hom	Verified	1.45677747281241	0.0725889080959757	no	481	0.0441179791350511	198	NA	FT		NUCLEUS		Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YNL095C_p	YNL095C	YNL095C	hom	Uncharacterized	1.45658669626892	0.0726152511051823	no	482	0.0687760436247809	327	NA					Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YDR435C	YDR435C	PPM1	hom	Verified	1.45556496491166	0.0727564595286684	no	483	0.106713394001503	444	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS			Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits	cellular protein complex assembly|C-terminal protein methylation	protein C-terminal leucine carboxyl O-methyltransferase activity	cellular_component
YPL264C_p	YPL264C	YPL264C	hom	Uncharacterized	1.45522586391231	0.072803371437468	no	484	0.060604033762959	229	NA					Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene	biological_process	molecular_function	integral to membrane
YER067W	YER067W	RGI1	hom	Verified	1.45520198975271	0.072806675108771	no	485	0.0520886179285229	194	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|PLASMA MEMBRANE		Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress	energy reserve metabolic process	molecular_function	cell periphery|nucleus|cytoplasm
YGR012W	YGR012W	YGR012W	hom	Verified	1.45413278140619	0.0729547483033066	no	486	0.0606357308106607	209	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Putative cysteine synthase, localized to the mitochondrial outer membrane	cysteine biosynthetic process	cysteine synthase activity	mitochondrial outer membrane|mitochondrion
YMR062C	YMR062C	ARG7	hom	Verified	1.45279634405225	0.0731401536688893	no	487	0.101294773247236	418	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine	fungal-type cell wall organization|ornithine biosynthetic process|arginine biosynthetic process	acetyl-CoA:L-glutamate N-acetyltransferase activity|glutamate N-acetyltransferase activity	mitochondrion|mitochondrial matrix
YMR115W	YMR115W	MGR3	hom	Verified	1.45045064163032	0.0734664469180908	no	488	0.0671015681045408	286	NA	FT	PROTEOLYSIS	MITOCHONDRION		Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA	misfolded or incompletely synthesized protein catabolic process	misfolded protein binding	mitochondrion|mitochondrial inner membrane|i-AAA complex
YOR123C	YOR123C	LEO1	hom	Verified	1.45020328371706	0.0735009198229675	no	489	0.0712885172493023	367	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	RNA POL II, HOLOENZYME	Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	chromatin organization|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription-coupled nucleotide-excision repair|histone H3-K4 trimethylation|transcription elongation from RNA polymerase II promoter	RNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|Cdc73/Paf1 complex
YAL005C	YAL005C	SSA1	hom	Verified	1.44860245677132	0.0737243173596295	no	490	0.0496793745266762	203	NA	FT	PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION	NUCLEUS		ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils	cytoplasmic translation|protein folding|protein refolding|protein targeting to mitochondrion|SRP-dependent cotranslational protein targeting to membrane, translocation|protein import into nucleus, translocation|response to stress	unfolded protein binding|ATPase activity	fungal-type vacuole membrane|fungal-type cell wall|plasma membrane|nucleus|polysome|chaperonin-containing T-complex|cytoplasm
YLL030C_d	YLL030C	RRT7	hom	Dubious	1.44633801187881	0.0740412095391951	no	491	0.0614260492001148	265	NA					Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR070W	YPR070W	MED1	hom	Verified	1.44504950750102	0.074221990067814	no	492	0.0998548578074221	427	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	molecular_function	core mediator complex
YDL171C	YDL171C	GLT1	hom	Verified	1.4417357358392	0.0746884691255086	no	493	0.0661722517145959	249	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source	glutamate biosynthetic process|ammonia assimilation cycle	glutamate synthase (NADH) activity	mitochondrion
YML087C	YML087C	AIM33	hom	Verified	1.44007657657182	0.074922867612381	no	494	0.0680497375444893	242	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YJR137C	YJR137C	MET5	hom	Verified	1.44003155355631	0.0749292360707532	no	495	0.0386213851049201	176	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS			Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine	fungal-type cell wall organization|sulfate assimilation	sulfite reductase (NADPH) activity	sulfite reductase complex (NADPH)|cytoplasm
YBR104W	YBR104W	YMC2	hom	Verified	1.4385849556959	0.0751340756658029	no	496	0.0523512302520621	220	NA	FT		MITOCHONDRION		Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication	mitochondrial transport|transmembrane transport	organic acid transmembrane transporter activity	mitochondrion|integral to membrane
YBR197C	YBR197C	YBR197C	hom	Verified	1.43783005668659	0.0752411394803721	no	497	0.0745760637062236	281	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YOL096C	YOL096C	COQ3	hom	Verified	1.43664315998291	0.0754097066600846	no	498	0.0736965716344355	351	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein	ubiquinone biosynthetic process	hexaprenyldihydroxybenzoate methyltransferase activity	mitochondrion|mitochondrial inner membrane|extrinsic to membrane
YDL088C	YDL088C	ASM4	hom	Verified	1.43526359196328	0.0756059992205791	no	499	0.0718598888291663	329	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication	nuclear pore organization|mRNA export from nucleus in response to heat stress|mitotic cell cycle spindle assembly checkpoint	nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding	nuclear pore central transport channel|integral to membrane|nuclear pore
YDR495C	YDR495C	VPS3	hom	Verified	1.43393981778981	0.0757947188886674	no	500	0.107666437812762	459	NA	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase	vacuole inheritance|vacuolar acidification|protein targeting to vacuole	molecular_function	CORVET complex|cytoplasm
YGR232W	YGR232W	NAS6	hom	Verified	1.43319113019621	0.0759016118856428	no	501	0.0800960112482533	337	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6	proteolysis|proteasome regulatory particle assembly	molecular_function	cytosol|nucleus|proteasome regulatory particle
YHR168W	YHR168W	MTG2	hom	Verified	1.43248885457854	0.076001982774268	no	502	0.0683136757326927	299	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM	MITOCHONDRION		Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly	cytoplasmic translation	ribosome binding|GTPase activity	mitochondrial inner membrane|extrinsic to membrane
YGL222C	YGL222C	EDC1	hom	Verified	1.43210782417414	0.0760564828112462	no	503	0.0678451574006124	252	NA	FT	RNA PROCESSING|TRANSLATION	NUCLEUS		RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of translation in response to stress	mRNA binding	nucleus|cytoplasm
YJR066W	YJR066W	TOR1	hom	Verified	1.42921207830822	0.076471643596965	no	504	0.060657865326249	280	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS|PLASMA MEMBRANE		PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication	regulation of cell cycle|G1 phase of mitotic cell cycle|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell growth|response to DNA damage stimulus|mitochondria-nucleus signaling pathway|ribosome biogenesis|meiosis|signal transduction|TOR signaling cascade|fungal-type cell wall organization|negative regulation of autophagy	protein binding|protein kinase activity	TORC1 complex|fungal-type vacuole membrane|endosome membrane|extrinsic to internal side of plasma membrane|plasma membrane|nucleus|Golgi membrane|cytoplasm
YDL095W	YDL095W	PMT1	hom	Verified	1.42829455471578	0.0766035472529286	no	505	0.105777052994526	356	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen	ER-associated misfolded protein catabolic process|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YLR269C_d	YLR269C	YLR269C	hom	Dubious	1.42566381578622	0.0769827029820881	no	506	0.0709679062036619	253	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL084C	YGL084C	GUP1	hom	Verified	1.42560524297039	0.0769911610033816	no	507	0.176563553467512	658	NA	FF|FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport	GPI anchor biosynthetic process|glycerol transport|glycerol catabolic process	O-acyltransferase activity	integral to membrane|endoplasmic reticulum|plasma membrane|membrane
YJL153C	YJL153C	INO1	hom	Verified	1.42365151077752	0.0772736883623498	no	508	0.0869994178132763	310	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM			Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element	inositol biosynthetic process	inositol-3-phosphate synthase activity	cytoplasm
YPR164W	YPR164W	MMS1	hom	Verified	1.42221911986235	0.0774813249536296	no	509	0.0788995095024659	389	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay	replication fork processing|negative regulation of transposition, RNA-mediated|recombinational repair|nonfunctional rRNA decay	molecular_function	Cul8-RING ubiquitin ligase complex
YPR008W	YPR008W	HAA1	hom	Verified	1.42070489216356	0.0777012848554336	no	510	0.0688909373476372	281	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress	response to acid|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YMR126C_p	YMR126C	DLT1	hom	Uncharacterized	1.4188810743547	0.0779668453935196	no	511	0.0593945232186546	260	NA					Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)	biological_process	molecular_function	cellular_component
YOR214C_p	YOR214C	YOR214C	hom	Uncharacterized	1.41755695242389	0.0781600778265892	no	512	0.0703161760311982	255	NA					Putative protein of unknown function; YOR214C is not an essential gene	biological_process	molecular_function	fungal-type cell wall
YLR367W	YLR367W	RPS22B	hom	Verified	1.41418530831844	0.0786537502482934	no	513	0.0719438249782267	285	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YOR133W	YOR133W	EFT1	hom	Verified	1.41329483504067	0.0787845260080407	no	514	0.0843198075958686	373	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication	translational elongation	translation elongation factor activity	ribosome
YCL016C	YCL016C	DCC1	hom	Verified	1.41212591609229	0.0789564445627942	no	515	0.104644462908033	432	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	CHROMOSOME		Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance	maintenance of DNA trinucleotide repeats|response to DNA damage stimulus|mitotic sister chromatid cohesion	molecular_function	Ctf18 RFC-like complex
YOR342C	YOR342C	YOR342C	hom	Verified	1.40932942003319	0.0793688916886227	no	516	0.0893267734017211	343	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YML011C	YML011C	RAD33	hom	Verified	1.40908669030451	0.0794047679701183	no	517	0.0667879987846536	294	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	nucleotide-excision repair	molecular_function	nucleus
YMR030W	YMR030W	RSF1	hom	Verified	1.4062154635239	0.079830076855415	no	518	0.0657806586508106	238	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes	transcription from mitochondrial promoter|calcium-mediated signaling|transcription from RNA polymerase II promoter|aerobic respiration	molecular_function	mitochondrion|nucleus
YEL072W	YEL072W	RMD6	hom	Verified	1.40525109837993	0.079973312119097	no	519	0.0810912344967432	325	NA	FT	CELL CYCLE			Protein required for sporulation	biological_process	molecular_function	cellular_component
YGL104C	YGL104C	VPS73	hom	Verified	1.40398162910996	0.0801621600630537	no	520	0.0934966246825296	348	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	MITOCHONDRION		Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family	transport|transmembrane transport|protein targeting to vacuole	substrate-specific transmembrane transporter activity	mitochondrion|integral to membrane
YPR083W	YPR083W	MDM36	hom	Verified	1.40067701940717	0.0806553388661758	no	521	0.0842611418804452	324	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission	mitochondrial fission|mitochondrion organization	molecular_function	mitochondrion|cytoplasm
YHR010W	YHR010W	RPL27A	hom	Verified	1.39985851871546	0.0807778449659696	no	522	0.0657313677680062	339	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR521W_d	YDR521W	YDR521W	hom	Dubious	1.39506446116203	0.0814982009352477	no	523	0.0606877696096675	221	NA					Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol	Unknown	Unknown	Unknown
YML104C	YML104C	MDM1	hom	Verified	1.39318173982882	0.0817824200647301	no	524	0.0472129688629582	196	NA	FT	MITOCHONDRION ORGANIZATION	CYTOSKELETON		Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)	nuclear migration|mitochondrion inheritance|mitochondrion organization	structural constituent of cytoskeleton|phosphatidylinositol-3-phosphate binding	intermediate filament|integral to membrane|cytoplasm
YPR072W	YPR072W	NOT5	hom	Verified	1.3927079376408	0.0818540636572993	no	525	0.0809660617293514	291	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation	deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination	ubiquitin-protein ligase activity	CCR4-NOT core complex|cytoplasm
YOL097W-A_p	YOL097W-A	YOL097W-A	hom	Uncharacterized	1.39246414881443	0.0818909453726788	no	526	0.0850521194008952	324	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YMR161W	YMR161W	HLJ1	hom	Verified	1.38803568025578	0.0825630902590717	no	527	0.0923298444746967	349	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ	ER-associated protein catabolic process	ATPase activator activity	endoplasmic reticulum|endoplasmic reticulum membrane
YIL055C_p	YIL055C	YIL055C	hom	Uncharacterized	1.38766017013032	0.0826202749359992	no	528	0.0825302631171872	312	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR014W	YOR014W	RTS1	hom	Verified	1.38757564020132	0.082633151712308	no	529	0.11380643524615	496	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON		B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A	mitotic cell cycle spindle orientation checkpoint|cellular protein localization|meiotic sister chromatid cohesion, centromeric|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|spindle pole body|condensed nuclear chromosome, centromeric region|cellular bud neck|cytoplasm
YDR249C_p	YDR249C	YDR249C	hom	Uncharacterized	1.38687135894271	0.0827404963700756	no	530	0.0691984374356755	282	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJR037W_d	YJR037W	YJR037W	hom	Dubious	1.38662764445254	0.0827776671065109	no	531	0.066384631155829	255	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces	Unknown	Unknown	Unknown
YNL294C	YNL294C	RIM21	hom	Verified	1.38500187273327	0.0830259473647865	no	532	0.108225232074106	467	NA	FF|FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS	PLASMA MEMBRANE		pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH	fungal-type cell wall biogenesis|ascospore formation|invasive growth in response to glucose limitation	molecular_function	integral to membrane
YPL121C	YPL121C	MEI5	hom	Verified	1.38359302222347	0.083241553057045	no	533	0.0588479826388303	233	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p	meiotic DNA recombinase assembly|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YKL110C	YKL110C	KTI12	hom	Verified	1.38101772058082	0.0836367560731106	no	534	0.0971507495945893	390	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p	regulation of transcription from RNA polymerase II promoter|cell growth|tRNA wobble uridine modification	chromatin binding	nucleus|cytoplasm
YOL018C	YOL018C	TLG2	hom	Verified	1.38064963025137	0.0836933577731525	no	535	0.210286003799614	730	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)	inositolphosphoceramide metabolic process|Golgi to vacuole transport|endocytosis|mannosyl-inositol phosphorylceramide metabolic process|protein exit from endoplasmic reticulum|vesicle fusion|CVT pathway	SNAP receptor activity	SNARE complex|trans-Golgi network|integral to endosome membrane
YEL060C	YEL060C	PRB1	hom	Verified	1.38035973686555	0.0837379552863515	no	536	0.0545344724274575	231	NA	FT	PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS			Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress	vacuolar protein catabolic process|sporulation resulting in formation of a cellular spore|cellular response to starvation	serine-type endopeptidase activity	fungal-type vacuole lumen|fungal-type vacuole
YJR133W	YJR133W	XPT1	hom	Verified	1.37992356936143	0.0838050894014125	no	537	0.0797767785078565	289	NA	FT	NUCLEOTIDE METABOLISM			Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine	XMP salvage|hypoxanthine metabolic process	xanthine phosphoribosyltransferase activity|hypoxanthine phosphoribosyltransferase activity	cytoplasm
YGL117W_p	YGL117W	YGL117W	hom	Uncharacterized	1.37974593580331	0.0838324420198349	no	538	0.136781234888586	538	NA	FF				Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOL077W-A	YOL077W-A	ATP19	hom	Verified	1.37968777097807	0.0838413998942095	no	539	0.0657845072966654	278	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase	mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YPL119C-A_p	YPL119C-A	YPL119C-A	hom	Uncharacterized	1.3790778040481	0.0839353832580412	no	540	0.0799451664301274	290	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YDR136C_d	YDR136C	VPS61	hom	Dubious	1.37817250287266	0.0840750173705669	no	541	0.195468101818072	639	NA	FF				Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YNL069C	YNL069C	RPL16B	hom	Verified	1.37747056615356	0.0841834044242596	no	542	0.108326851283604	408	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YNL220W	YNL220W	ADE12	hom	Verified	1.3772797375536	0.0842128886664147	no	543	0.0687596362506444	258	NA	FT	NUCLEOTIDE METABOLISM			Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence	purine nucleotide biosynthetic process	DNA replication origin binding|adenylosuccinate synthase activity	cytoplasm
YGR026W_p	YGR026W	YGR026W	hom	Uncharacterized	1.37670059379751	0.0843024175461014	no	544	0.0874704764941048	308	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	integral to membrane
YJR129C_p	YJR129C	YJR129C	hom	Uncharacterized	1.37550483146009	0.0844874944401854	no	545	0.0705344922390403	317	NA					Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cytoplasm
YGR097W	YGR097W	ASK10	hom	Verified	1.37309730427359	0.0848610494982587	no	546	0.0841219881900472	295	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS	RNA POL II, HOLOENZYME	Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication	cellular protein catabolic process|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glycerol transport	molecular_function	DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YGR288W	YGR288W	MAL13	hom	Verified	1.37194850407077	0.0850397346501271	no	547	0.0816432837574139	374	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C	cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent	sequence-specific DNA binding transcription factor activity	nucleus
YGR259C_d	YGR259C	YGR259C	hom	Dubious	1.3718572305147	0.0850539434834522	no	548	0.0740978462998188	336	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W	Unknown	Unknown	Unknown
YFL041W	YFL041W	FET5	hom	Verified	1.37017435730308	0.0853162404373159	no	549	0.0626602851247374	257	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS	PLASMA MEMBRANE		Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport	iron ion transport	ferroxidase activity	fungal-type vacuole membrane|integral to membrane
YKL202W_d	YKL202W	YKL202W	hom	Dubious	1.36790522746416	0.0856708716400384	no	550	0.0602315116097161	223	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL096C_d	YDL096C	OPI6	hom	Dubious	1.36723963314848	0.0857751031680996	no	551	0.071625234871065	280	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential	Unknown	Unknown	Unknown
YIR017C	YIR017C	MET28	hom	Verified	1.36701189434101	0.0858107886677041	no	552	0.112668256635311	385	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism	regulation of transcription from RNA polymerase II promoter|regulation of sulfur amino acid metabolic process|Unknown	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YJR094C	YJR094C	IME1	hom	Verified	1.36587558781721	0.0859890081174805	no	553	0.056132598857309	221	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p	pseudohyphal growth|regulation of transcription from RNA polymerase II promoter|regulation of meiosis	protein binding transcription factor activity	nucleus
YKL068W-A_p	YKL068W-A	YKL068W-A	hom	Uncharacterized	1.3637349571723	0.086325498872269	no	554	0.128406530021084	471	NA					Putative protein of unknown function; identified by homology to <i>Ashbya gossypii</i>	biological_process	molecular_function	cellular_component
YDR463W	YDR463W	STP1	hom	Verified	1.36304827027514	0.0864336491339537	no	555	0.1686654921504	527	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS|PLASMA MEMBRANE		Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication	positive regulation of transcription, DNA-dependent|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	plasma membrane|nucleus|cytoplasm
YAL037C-A_p	YAL037C-A	YAL037C-A	hom	Uncharacterized	1.36178501418199	0.0866328711452999	no	556	0.0887387154922295	359	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR029C	YMR029C	FAR8	hom	Verified	1.36067265133659	0.0868085805049847	no	557	0.0699011220635282	284	NA	FT	CELL CYCLE|SIGNALING	ENDOPLASMIC RETICULUM		Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	cellular_component
YDL080C	YDL080C	THI3	hom	Verified	1.36010980035538	0.0868975901059955	no	558	0.0744182080217142	291	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis	regulation of thiamine biosynthetic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|positive regulation of transcription from RNA polymerase II promoter|leucine catabolic process	carboxy-lyase activity	cytosol|nucleus
YGL156W	YGL156W	AMS1	hom	Verified	1.35933296716958	0.0870205509550873	no	559	0.0836933881589004	305	NA	FT	CARBOHYDRATE METABOLISM			Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway	oligosaccharide catabolic process|cellular carbohydrate metabolic process	alpha-mannosidase activity	fungal-type vacuole membrane
YER028C	YER028C	MIG3	hom	Verified	1.3588722202371	0.0870935415417518	no	560	0.0841920975693258	360	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication	cellular response to UV|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|response to DNA damage stimulus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nuclear chromatin
YOL126C	YOL126C	MDH2	hom	Verified	1.35869823291962	0.0871211161464744	no	561	0.0837634297620493	373	NA	FT	PROTEIN LOCALIZATION|KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|PEROXISOME ORGANIZATION			Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1	protein import into peroxisome matrix|gluconeogenesis|malate metabolic process	L-malate dehydrogenase activity	cytosol|cytoplasm
YNL122C_p	YNL122C	YNL122C	hom	Uncharacterized	1.35838293209507	0.0871711036175137	no	562	0.0816401960193618	378	NA	FT	TRANSLATION	MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene	biological_process	molecular_function	mitochondrion
YPL269W	YPL269W	KAR9	hom	Verified	1.35727117192432	0.0873475318425105	no	563	0.123038355112811	499	NA	FT		NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase	nuclear migration along microtubule|establishment of spindle localization	molecular_function	cell cortex|spindle pole body|mating projection tip
YHR086W	YHR086W	NAM8	hom	Verified	1.35625058964311	0.0875097253424955	no	564	0.0847900238270758	337	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS|MITOCHONDRION		RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function	mRNA splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|mRNA splice site selection	mRNA binding|RNA binding	commitment complex|U1 snRNP|U2-type prespliceosome
YKL166C	YKL166C	TPK3	hom	Verified	1.35587497752809	0.0875694751122383	no	565	0.0621339589122361	249	NA	FT	SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication	protein phosphorylation|mitochondrion organization|Ras protein signal transduction	cAMP-dependent protein kinase activity|protein kinase activity	cAMP-dependent protein kinase complex|nucleus|cytoplasm
YGR101W	YGR101W	PCP1	hom	Verified	1.35501075923336	0.087707064555347	no	566	0.101763719728678	390	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases	signal peptide processing|regulation of mitochondrion organization	serine-type endopeptidase activity	integral to membrane|mitochondrial inner membrane
YMR007W_d	YMR007W	YMR007W	hom	Dubious	1.35170815105166	0.0882343482536712	no	567	0.0562941558710195	253	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL205W	YKL205W	LOS1	hom	Verified	1.35121736023479	0.0883129075484595	no	568	0.091967933704904	311	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS|MITOCHONDRION		Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus	tRNA binding|Ran GTPase binding	mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YER039C-A_p	YER039C-A	YER039C-A	hom	Uncharacterized	1.35088543722036	0.0883660669293359	no	569	0.0840521043332484	358	NA					Putative protein of unknown function; YER039C-A is not an essential gene	biological_process	molecular_function	integral to membrane
YCL012C	YCL012C	YCL012C	hom	Verified	1.35007012234996	0.0884967455139101	no	570	0.0745184727010574	273	NA					Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene	biological_process	molecular_function	cellular_component
YGL219C	YGL219C	MDM34	hom	Verified	1.34925026964904	0.0886282965467241	no	571	0.121179753460939	422	NA	FT	MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth	mitochondrion organization|phospholipid transport	molecular_function	mitochondrial outer membrane|ERMES complex|mitochondrion|cytoplasm
YDR309C	YDR309C	GIC2	hom	Verified	1.34776752928502	0.0888665823167483	no	572	0.0722836808347984	294	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region	regulation of exit from mitosis|establishment of cell polarity|axial cellular bud site selection|Rho protein signal transduction	Rho GTPase binding|Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding	incipient cellular bud site|actin cap|plasma membrane|mating projection tip|cellular bud tip
YLR214W	YLR214W	FRE1	hom	Verified	1.34716483307543	0.0889635756450611	no	573	0.070844796520086	286	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YBL081W_p	YBL081W	YBL081W	hom	Uncharacterized	1.3468025438638	0.0890219176168879	no	574	0.0693915253652857	256	NA					Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport	biological_process	molecular_function	cellular_component
YJR098C_p	YJR098C	YJR098C	hom	Uncharacterized	1.34620633555279	0.0891179912104008	no	575	0.0699648269237404	260	NA	FT	LIPID METABOLISM	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YHR064C	YHR064C	SSZ1	hom	Verified	1.34564168888812	0.0892090500528157	no	576	0.0749054731734411	339	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION			Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP	cytoplasmic translation|regulation of translational fidelity|rRNA processing	unfolded protein binding	polysome|cytoplasm
YDL138W	YDL138W	RGT2	hom	Verified	1.34338963417623	0.0895729208090139	no	577	0.0625825582715013	223	NA	FT	SIGNALING	PLASMA MEMBRANE		Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication	glucose transport|signal transduction|detection of glucose	glucose transmembrane transporter activity|receptor activity|glucose binding	integral to membrane|plasma membrane
YBR200W	YBR200W	BEM1	hom	Verified	1.34326112233297	0.0895937180638093	no	578	0.0723060054669199	307	NA	FT		SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p	establishment of cell polarity|cell morphogenesis involved in conjugation with cellular fusion	protein complex scaffold|phosphatidylinositol-3-phosphate binding	incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip
YMR096W	YMR096W	SNZ1	hom	Verified	1.34280893194911	0.089666925223484	no	579	0.0641075297462812	245	NA	FT	COFACTOR METABOLISM			Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins	pyridoxine metabolic process|thiamine biosynthetic process	protein binding	cellular_component
YDR296W	YDR296W	MHR1	hom	Verified	1.34134449974204	0.0899043140600025	no	580	0.11335181556636	418	NA	FT	MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress	cellular response to oxidative stress|positive regulation of mitochondrial DNA replication|regulation of transcription, DNA-dependent|mitochondrial genome maintenance|DNA recombination	single-stranded DNA binding|recombinase activity|DNA binding	mitochondrion|nucleus
YDR508C	YDR508C	GNP1	hom	Verified	1.34039138235107	0.0900590679666058	no	581	0.0685885630111933	256	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity|L-proline transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YJL007C_d	YJL007C	YJL007C	hom	Dubious	1.33995712205414	0.0901296426915477	no	582	0.0846240296739161	325	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLL020C_d	YLL020C	YLL020C	hom	Dubious	1.33928622852736	0.0902387551207499	no	583	0.0740718505010753	329	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1	Unknown	Unknown	Unknown
YPL073C_d	YPL073C	YPL073C	hom	Dubious	1.33776522520753	0.0904864905743046	no	584	0.0730085615495443	308	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments	Unknown	Unknown	Unknown
YNL074C	YNL074C	MLF3	hom	Verified	1.33736431734943	0.0905518729890108	no	585	0.0743448546762532	283	NA					Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide	response to drug	molecular_function	cytoplasm
YOR032C	YOR032C	HMS1	hom	Verified	1.33623393668978	0.0907364109656266	no	586	0.103276068751597	396	NA	FT		NUCLEUS		Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant	pseudohyphal growth	sequence-specific DNA binding transcription factor activity	cellular_component
YJR091C	YJR091C	JSN1	hom	Verified	1.33118235261636	0.091564508330813	no	587	0.0647898131691596	274	NA	FT	PROTEIN LOCALIZATION	MITOCHONDRION		Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|cellular protein complex localization|establishment of mitochondrion localization	mRNA binding	external side of mitochondrial outer membrane
YMR262W_p	YMR262W	YMR262W	hom	Uncharacterized	1.3282316421066	0.0920507971215937	no	588	0.0854173280887751	372	NA					Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene	biological_process	molecular_function	cellular_component
YBL063W	YBL063W	KIP1	hom	Verified	1.32720928963604	0.0922197301368137	no	589	0.0700721159598166	227	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions	mitotic anaphase B|microtubule depolymerization|spindle pole body separation|plasmid partitioning|mitotic sister chromatid segregation	microtubule motor activity|structural constituent of cytoskeleton	spindle microtubule|kinesin complex|spindle pole body
YAL007C	YAL007C	ERP2	hom	Verified	1.32647167728388	0.0923417552742765	no	590	0.0915819351712605	361	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles	ER to Golgi vesicle-mediated transport	molecular_function	ER to Golgi transport vesicle
YNL130C	YNL130C	CPT1	hom	Verified	1.32585512316592	0.0924438450824418	no	591	0.0755161903792583	311	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication	CDP-choline pathway	diacylglycerol cholinephosphotransferase activity	mitochondrial outer membrane|integral to membrane|Golgi apparatus
YNR037C	YNR037C	RSM19	hom	Verified	1.32519277194848	0.0925536110539954	no	592	0.113722730123233	411	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YPL054W	YPL054W	LEE1	hom	Verified	1.32487869728027	0.092605693729803	no	593	0.0722810338374409	294	NA					Zinc-finger protein of unknown function	biological_process	molecular_function	cellular_component
YPR032W	YPR032W	SRO7	hom	Verified	1.31996723035675	0.0934229795790913	no	594	0.0965555094575001	409	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING	PLASMA MEMBRANE		Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication	establishment of cell polarity|exocytosis|Golgi to plasma membrane transport|small GTPase mediated signal transduction	SNARE binding|Rab GTPase binding	cytosol|plasma membrane
YBR177C	YBR177C	EHT1	hom	Verified	1.31700209428498	0.0939189612826008	no	595	0.0866739473004506	335	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication	medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process|cellular lipid metabolic process	short-chain carboxylesterase activity|alcohol O-butanoyltransferase activity|serine hydrolase activity	mitochondrial outer membrane|mitochondrion|lipid particle
YJL196C	YJL196C	ELO1	hom	Verified	1.31662067019118	0.0939829033339947	no	596	0.0677190379581391	286	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication	fatty acid elongation, unsaturated fatty acid	fatty acid elongase activity	integral to membrane|membrane
YKR099W	YKR099W	BAS1	hom	Verified	1.31465197065284	0.0943134476017016	no	597	0.0982719561055895	371	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes	positive regulation of transcription from RNA polymerase II promoter	core promoter sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YLR342W-A_p	YLR342W-A	YLR342W-A	hom	Uncharacterized	1.31291983290664	0.0946049815546858	no	598	0.0985941353673033	386	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YER121W_p	YER121W	YER121W	hom	Uncharacterized	1.31050269233864	0.0950129170087348	no	599	0.113144365865357	401	NA					Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy	biological_process	molecular_function	cellular_component
YPL260W	YPL260W	YPL260W	hom	Verified	1.3091884623414	0.0952352597386281	no	600	0.11752369878863	423	NA	FT		NUCLEUS		Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YBL057C	YBL057C	PTH2	hom	Verified	1.30916501381359	0.0952392302596038	no	601	0.109612724394488	424	NA	FT	PROTEOLYSIS	MITOCHONDRION		One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	aminoacyl-tRNA hydrolase activity	mitochondrial outer membrane|mitochondrion|cytoplasm
YNL224C	YNL224C	SQS1	hom	Verified	1.30608971879109	0.0957610244296662	no	602	0.0893665751632512	411	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM	NUCLEUS		Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress	positive regulation of helicase activity|positive regulation of ATPase activity|mRNA splicing, via spliceosome|maturation of SSU-rRNA|rRNA processing	molecular_function	preribosome, small subunit precursor|nucleus|preribosome, large subunit precursor|90S preribosome|cytoplasm
YGL021W	YGL021W	ALK1	hom	Verified	1.30505908285209	0.0959363650610634	no	603	0.0972210267310377	366	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION			Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins	mitosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YBL065W_d	YBL065W	YBL065W	hom	Dubious	1.30457332526255	0.0960190881310473	no	604	0.106929284441126	363	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene	Unknown	Unknown	Unknown
YDL156W	YDL156W	CMR1	hom	Verified	1.30326996072321	0.0962413063790548	no	605	0.107585447684715	393	NA	FT		NUCLEUS|CHROMOSOME		DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS	biological_process	DNA binding	nuclear chromatin|nucleus|cytoplasm
YDR497C	YDR497C	ITR1	hom	Verified	1.30315330702662	0.0962612137661435	no	606	0.0827089863765451	295	NA	FT		PLASMA MEMBRANE		Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress	myo-inositol transport|transmembrane transport	myo-inositol transmembrane transporter activity	integral to membrane|plasma membrane|membrane
YOR227W	YOR227W	HER1	hom	Verified	1.30202459415163	0.0964539891564719	no	607	0.10418681804136	376	NA	FT		MITOCHONDRION		Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication	endoplasmic reticulum organization	molecular_function	mitochondrion|ribosome|cytoplasm
YOL098C_p	YOL098C	YOL098C	hom	Uncharacterized	1.30061394729699	0.096695315283391	no	608	0.0967556237310076	402	NA	FT	PROTEOLYSIS			Putative metalloprotease	biological_process	molecular_function	cytoplasm
YDL133W	YDL133W	SRF1	hom	Verified	1.29956372908296	0.0968752689210881	no	609	0.146060957505373	482	NA					Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients	positive regulation of catalytic activity	molecular_function	integral to membrane
YDR225W	YDR225W	HTA1	hom	Verified	1.29861019359705	0.0970388689608331	no	610	0.103255837595935	450	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME	RSC COMPLEX	Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p	DNA repair|chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter	DNA binding	replication fork protection complex|nuclear nucleosome
YIL159W	YIL159W	BNR1	hom	Verified	1.29851247066883	0.0970556469341113	no	611	0.0928277903053964	356	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1	barbed-end actin filament capping|actin filament bundle assembly|formin-nucleated actin cable assembly	profilin binding	cellular bud neck
YLR217W_d	YLR217W	YLR217W	hom	Dubious	1.29680839063029	0.0973485614846715	no	612	0.104171546827158	343	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6	Unknown	Unknown	Unknown
YPL036W	YPL036W	PMA2	hom	Verified	1.29292405936422	0.0980186626791943	no	613	0.0716441378248893	242	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential	proton transport|regulation of pH	hydrogen-exporting ATPase activity, phosphorylative mechanism	mitochondrion|integral to membrane|plasma membrane
YDR511W	YDR511W	ACN9	hom	Verified	1.28879583692772	0.0987345368608689	no	614	0.0726411486242047	287	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes	carbon utilization|regulation of gluconeogenesis	molecular_function	mitochondrion|mitochondrial intermembrane space
YOR364W_d	YOR364W	YOR364W	hom	Dubious	1.28796843402413	0.0988784757725923	no	615	0.0802689345792154	291	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C	Unknown	Unknown	Unknown
YDR522C	YDR522C	SPS2	hom	Verified	1.28726321506722	0.0990012801370653	no	616	0.0833550653123278	367	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component	ascospore wall assembly|ascospore formation	molecular_function	fungal-type cell wall|plasma membrane
YBR207W	YBR207W	FTH1	hom	Verified	1.28525426281739	0.0993517236042324	no	617	0.0562731992913985	242	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS			Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress	endocytosis|high-affinity iron ion transport	iron ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YBR260C	YBR260C	RGD1	hom	Verified	1.28296811752885	0.0997516230907703	no	618	0.0763963513041691	316	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization	response to acid|osmosensory signaling pathway	Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding	cellular bud|mating projection tip|actin cortical patch
YJL168C	YJL168C	SET2	hom	Verified	1.28021705233017	0.100234405161814	no	619	0.0886384811981621	368	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p	negative regulation of histone H3-K14 acetylation|DNA-dependent transcription, elongation|ascospore formation|regulation of transcription, DNA-dependent|histone deacetylation|regulation of DNA-dependent DNA replication initiation|histone methylation|negative regulation of antisense RNA transcription|Unknown|negative regulation of reciprocal meiotic recombination|positive regulation of histone acetylation	histone methyltransferase activity|histone methyltransferase activity (H3-K36 specific)	nucleus
YKL086W	YKL086W	SRX1	hom	Verified	1.27963648329127	0.100336506306283	no	620	0.0916304336562096	352	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress	sulfiredoxin activity	nucleus|cytoplasm
YOR309C_d	YOR309C	YOR309C	hom	Dubious	1.2791907789035	0.100414941111812	no	621	0.124211806203093	441	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58	Unknown	Unknown	Unknown
YJR116W_p	YJR116W	TDA4	hom	Uncharacterized	1.27910052354673	0.100430829644251	no	622	0.0554338731446158	227	NA					Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	integral to membrane
YDR085C	YDR085C	AFR1	hom	Verified	1.27829817852043	0.10057215492532	no	623	0.0947516162122863	372	NA	FT	SIGNALING			Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication	regulation of G-protein coupled receptor protein signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation	receptor signaling protein activity	mating projection base
YDR068W	YDR068W	DOS2	hom	Verified	1.27738223560922	0.100733666648641	no	624	0.0738891416571067	289	NA					Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YNL106C	YNL106C	INP52	hom	Verified	1.27706013418516	0.100790508960156	no	625	0.0681557562455824	292	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity	mating projection tip|cytoplasm|actin cortical patch
YOR134W	YOR134W	BAG7	hom	Verified	1.27556613432365	0.101054465954575	no	626	0.108528099898238	425	NA	FT	SIGNALING			Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p	small GTPase mediated signal transduction	Rho GTPase activator activity	intracellular
YLR241W_p	YLR241W	YLR241W	hom	Uncharacterized	1.27454455666571	0.101235246142479	no	627	0.0827749380131126	290	NA					Putative protein of unknown function, may be involved in detoxification	biological_process	molecular_function	integral to membrane
YNL184C_p	YNL184C	YNL184C	hom	Uncharacterized	1.27342773584561	0.101433150233235	no	628	0.125421602743216	463	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YLR253W_p	YLR253W	YLR253W	hom	Uncharacterized	1.27309505071107	0.101492157504767	no	629	0.101756442096109	388	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene	biological_process	molecular_function	mitochondrion
YDR051C	YDR051C	DET1	hom	Verified	1.27274779168007	0.101553776364375	no	630	0.0873004941186875	286	NA	FT		NUCLEUS		Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel	intracellular sterol transport|dephosphorylation	acid phosphatase activity	nucleus|cytoplasm
YMR056C	YMR056C	AAC1	hom	Verified	1.27232802125611	0.101628298265861	no	631	0.0917893581920466	402	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	heme biosynthetic process|mitochondrial transport|heme transport|aerobic respiration	ATP:ADP antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YBR119W	YBR119W	MUD1	hom	Verified	1.27098788261689	0.101866479742336	no	632	0.123448522054048	426	NA	FT	RNA PROCESSING	NUCLEUS		U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing	mRNA splicing, via spliceosome	U1 snRNA binding|RNA binding	U1 snRNP|U2-type prespliceosome
YIL125W	YIL125W	KGD1	hom	Verified	1.26937913547379	0.102152937030236	no	633	0.113077773126354	420	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA	tricarboxylic acid cycle|2-oxoglutarate metabolic process	oxoglutarate dehydrogenase (succinyl-transferring) activity	mitochondrial nucleoid|mitochondrion|mitochondrial matrix|mitochondrial oxoglutarate dehydrogenase complex
YNL323W	YNL323W	LEM3	hom	Verified	1.26812996611918	0.10237577090652	no	634	0.195469677114152	704	NA	FF|FT	MEMBRANE ORGANIZATION|SIGNALING	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane	phospholipid translocation|cell surface receptor signaling pathway	phospholipid-translocating ATPase activity	integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YDL113C	YDL113C	ATG20	hom	Verified	1.26667660334646	0.102635474584507	no	635	0.0852230668769263	318	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate	mitochondrion degradation|early endosome to Golgi transport|macroautophagy|CVT pathway	phosphatidylinositol-3-phosphate binding	endosome|pre-autophagosomal structure|extrinsic to membrane
YIL090W	YIL090W	ICE2	hom	Verified	1.26350238326309	0.103204345327986	no	636	0.112901620963924	402	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells	endoplasmic reticulum inheritance	molecular_function	integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum
YNL257C	YNL257C	SIP3	hom	Verified	1.26342449565914	0.1032183327479	no	637	0.128608602357171	489	NA	FT	TRANSCRIPTION FROM RNA POL II			Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	transcription cofactor activity	integral to membrane
YLR318W	YLR318W	EST2	hom	Verified	1.26200830633194	0.103472898747485	no	638	0.0999832255282145	413	NA	FT		NUCLEUS|CHROMOSOME		Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia	telomere maintenance via telomerase|replicative cell aging	telomerase activity|telomeric template RNA reverse transcriptase activity|telomeric DNA binding	telomerase catalytic core complex|nucleolus|nucleus|telomerase holoenzyme complex
YBL002W	YBL002W	HTB2	hom	Verified	1.26150462814228	0.103563546789112	no	639	0.0791296529625125	296	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation	chromatin assembly or disassembly	DNA binding	replication fork protection complex|nuclear nucleosome
YPL249C	YPL249C	GYP5	hom	Verified	1.25906212181531	0.104003947269079	no	640	0.0884520468504914	319	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress	vesicle-mediated transport|ER to Golgi vesicle-mediated transport	Rab GTPase activator activity	cytosol|incipient cellular bud site|plasma membrane|cellular bud neck|Golgi-associated vesicle|cellular bud tip
YPR015C_p	YPR015C	YPR015C	hom	Uncharacterized	1.25901717713301	0.104012063805377	no	641	0.112761790998755	393	NA					Putative protein of unknown function; overexpression causes a cell cycle delay or arrest	biological_process	sequence-specific DNA binding	cellular_component
YBR271W	YBR271W	EFM2	hom	Verified	1.25898853506671	0.104017236500524	no	642	0.126030636761382	415	NA					S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis	peptidyl-lysine methylation	S-adenosylmethionine-dependent methyltransferase activity|protein-lysine N-methyltransferase activity	cytoplasm
YDR379C-A	YDR379C-A	YDR379C-A	hom	Verified	1.25812085394384	0.104174026261013	no	643	0.12049447665589	462	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy	mitochondrial respiratory chain complex II assembly	molecular_function	mitochondrion
YKL188C	YKL188C	PXA2	hom	Verified	1.25785580993918	0.104221953787947	no	644	0.0920125202274777	358	NA	FT	NUCLEOTIDE METABOLISM			Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder	fatty acid transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|integral to peroxisomal membrane
YGR154C	YGR154C	GTO1	hom	Verified	1.25758331729622	0.104271244902551	no	645	0.0980197068592636	366	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization	glutathione metabolic process	glutathione transferase activity	peroxisome
YDL230W	YDL230W	PTP1	hom	Verified	1.25585407237172	0.104584441384796	no	646	0.0814804027757383	284	NA	FT		MITOCHONDRION		Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation	pseudohyphal growth|invasive growth in response to glucose limitation|protein dephosphorylation	protein tyrosine phosphatase activity	mitochondrion|cytoplasm
YCL026C-B	YCL026C-B	HBN1	hom	Verified	1.25321936038826	0.105062943005155	no	647	0.116785748940326	459	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress	biological_process	NAD(P)H nitroreductase activity	nucleus|cytoplasm
YNL242W	YNL242W	ATG2	hom	Verified	1.25291043711572	0.105119151538596	no	648	0.0964557256719393	359	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress	mitochondrion degradation|piecemeal microautophagy of nucleus|peroxisome degradation|CVT pathway|autophagic vacuole assembly	molecular_function	pre-autophagosomal structure|cytoplasm|extrinsic to membrane
YPR065W	YPR065W	ROX1	hom	Verified	1.25183323997451	0.105315317607403	no	649	0.110273783787092	446	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance	negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|DNA binding, bending|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity	nuclear chromatin
YIR027C	YIR027C	DAL1	hom	Verified	1.25002459614626	0.105645281272297	no	650	0.119671595989175	424	NA					Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression	allantoin assimilation pathway	allantoinase activity	cellular_component
YNR004W_p	YNR004W	SWM2	hom	Uncharacterized	1.24976781530503	0.105692188143348	no	651	0.0994824518826859	393	NA	FT		NUCLEUS		Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds	biological_process	molecular_function	nucleolus
YLL052C	YLL052C	AQY2	hom	Verified	1.24934544268597	0.105769376875859	no	652	0.115977119664396	425	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains	water transport	water channel activity	plasma membrane|endoplasmic reticulum membrane
YDR482C	YDR482C	CWC21	hom	Verified	1.24741125612407	0.10612337068966	no	653	0.123112242261553	465	NA	FT	RNA PROCESSING	NUCLEUS		Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YLR143W	YLR143W	DPH6	hom	Verified	1.24716672330878	0.106168185831509	no	654	0.13425060610174	463	NA					Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene	biological_process	molecular_function	cytoplasm
YKL051W	YKL051W	SFK1	hom	Verified	1.24515231283795	0.106537883902922	no	655	0.0625299705924285	274	NA	FT	LIPID METABOLISM|SIGNALING|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane	vacuole organization|inositol lipid-mediated signaling|actin cytoskeleton organization	molecular_function	integral to membrane|plasma membrane
YMR204C	YMR204C	INP1	hom	Verified	1.24483976307619	0.106595328307084	no	656	0.0956888141623482	350	NA	FT	PEROXISOME ORGANIZATION			Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane	peroxisome inheritance	molecular_function	peroxisome|extrinsic to intraperoxisomal membrane
YLR089C	YLR089C	ALT1	hom	Verified	1.24445090375954	0.106666829067984	no	657	0.0992962374140239	384	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive	alanine catabolic process|alanine biosynthetic process	L-alanine:2-oxoglutarate aminotransferase activity	mitochondrion
YIL127C_p	YIL127C	RRT14	hom	Uncharacterized	1.24375940051043	0.106794063399031	no	658	0.0975450939888275	383	NA	FT		NUCLEUS		Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	nucleolus
YIL006W	YIL006W	YIA6	hom	Verified	1.23725992926154	0.107995299520938	no	659	0.118247165963324	415	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs	transport|mitochondrial pyruvate transport|NAD transmembrane transport	pyruvate secondary active transmembrane transporter activity|transporter activity|NAD transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YGL096W	YGL096W	TOS8	hom	Verified	1.2370499621338	0.108034267344621	no	660	0.08903255156401	298	NA	FT		NUCLEUS|CHROMOSOME		Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication	biological_process	chromatin binding|sequence-specific DNA binding	nuclear chromatin
YBR006W	YBR006W	UGA2	hom	Verified	1.22943711141369	0.109453981592854	no	661	0.137842214419081	585	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm	cellular response to oxidative stress|gamma-aminobutyric acid catabolic process|glutamate decarboxylation to succinate	succinate-semialdehyde dehydrogenase [NAD(P)+] activity	cytoplasm
YEL017C-A	YEL017C-A	PMP2	hom	Verified	1.22802176397844	0.109719399027322	no	662	0.125037765041164	455	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication	cation transport	molecular_function	membrane
YGR049W	YGR049W	SCM4	hom	Verified	1.22772365016005	0.109775362607813	no	663	0.117587947367506	358	NA	FT		MITOCHONDRION		Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to membrane
YBR045C	YBR045C	GIP1	hom	Verified	1.22730657194951	0.109853693225418	no	664	0.123856256581842	500	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p	ascospore wall assembly|regulation of phosphoprotein phosphatase activity	protein phosphatase type 1 regulator activity|protein phosphatase 1 binding	protein phosphatase type 1 complex|prospore membrane
YKR078W	YKR078W	YKR078W	hom	Verified	1.22683361618993	0.10994256661929	no	665	0.115426684692322	436	NA					Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)	biological_process	phosphatidylinositol-3-phosphate binding	cytoplasm
YLL006W-A_p	YLL006W-A	YLL006W-A	hom	Uncharacterized	1.2259767850597	0.110103705640112	no	666	0.0817482491124153	319	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YOL065C	YOL065C	INP54	hom	Verified	1.22518084824021	0.110253544368604	no	667	0.083056566523609	313	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins	phosphatidylinositol dephosphorylation	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	endoplasmic reticulum
YLL016W	YLL016W	SDC25	hom	pseudogene	1.22451584431729	0.110378846475941	no	668	0.103315003506281	382	NA	FT	SIGNALING			Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication	Ras protein signal transduction	Ras guanyl-nucleotide exchange factor activity	cellular_component
YBL079W	YBL079W	NUP170	hom	Verified	1.22328594253907	0.1106108573844	no	669	0.134829822692359	503	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication	nucleocytoplasmic transport|chromosome segregation|protein targeting to nuclear inner membrane|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YCL076W_d	YCL076W	YCL076W	hom	Dubious	1.2224699117913	0.110764987677456	no	670	0.08073587902341	314	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR042W	YOR042W	CUE5	hom	Verified	1.2223133773851	0.11079457117335	no	671	0.120635004965118	434	NA					Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	ubiquitin binding	cytoplasm
YIL066C	YIL066C	RNR3	hom	Verified	1.22109005017707	0.111025963257136	no	672	0.102395937171451	430	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM	MITOCHONDRION		Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits	deoxyribonucleotide biosynthetic process	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	mitochondrion|ribonucleoside-diphosphate reductase complex|cytoplasm
YBR187W_p	YBR187W	GDT1	hom	Uncharacterized	1.21958125517952	0.111311827938555	no	673	0.116185435334442	458	NA					Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YMR242C	YMR242C	RPL20A	hom	Verified	1.21500478088252	0.112182133976793	no	674	0.114484565301471	482	NA	FF|FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR182W	YLR182W	SWI6	hom	Verified	1.2144242392294	0.112292881977389	no	675	0.1440122756231	506	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of reciprocal meiotic recombination|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity	SBF transcription complex|MBF transcription complex|nucleus|cytoplasm
YGL217C_d	YGL217C	YGL217C	hom	Dubious	1.21276909492663	0.112609057199926	no	676	0.0900346672331439	338	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W	Unknown	Unknown	Unknown
YOR315W	YOR315W	SFG1	hom	Verified	1.21253104191818	0.112654583707808	no	677	0.10499944815501	378	NA	FT	CELL CYCLE	NUCLEUS		Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate	mitotic cell cycle|pseudohyphal growth	molecular_function	nucleus|cytoplasm
YNL202W	YNL202W	SPS19	hom	Verified	1.21215113274372	0.112727266758953	no	678	0.13222746454586	508	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate	fatty acid catabolic process|ascospore formation	2,4-dienoyl-CoA reductase (NADPH) activity	peroxisomal matrix
YDL114W_p	YDL114W	YDL114W	hom	Uncharacterized	1.21147337212832	0.112857016971367	no	679	0.114913426975687	405	NA	FT	OXIDATION-REDUCTION PROCESS			Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene	biological_process	molecular_function	integral to membrane
YFL004W	YFL004W	VTC2	hom	Verified	1.21016506868785	0.113107779502705	no	680	0.105739488870972	344	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion	polyphosphate metabolic process|vacuolar transport|microautophagy|protein localization|vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex
YMR001C-A_p	YMR001C-A	YMR001C-A	hom	Uncharacterized	1.20323788434006	0.114442139245887	no	681	0.103555373588815	462	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR186W	YBR186W	PCH2	hom	Verified	1.20291639652262	0.114504337306281	no	682	0.0788217115596382	291	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation	meiotic recombination checkpoint|meiotic DNA double-strand break formation|reciprocal meiotic recombination	ATPase activity	nucleolus
YGR034W	YGR034W	RPL26B	hom	Verified	1.20047480562511	0.114977495855385	no	683	0.134814917069993	476	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YJR145C	YJR145C	RPS4A	hom	Verified	1.19920283709326	0.115224542188451	no	684	0.107877321927036	420	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasm|90S preribosome
YNL146C-A_p	YNL146C-A	YNL146C-A	hom	Uncharacterized	1.19915641539738	0.115233565510031	no	685	0.105141553389024	388	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJL103C	YJL103C	GSM1	hom	Verified	1.19663178791883	0.1157250523876	no	686	0.121618997503776	449	NA	FT	TRANSCRIPTION FROM RNA POL II|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis	oxidative phosphorylation	sequence-specific DNA binding|DNA binding	cellular_component
YMR154C	YMR154C	RIM13	hom	Verified	1.19555542538506	0.115935047475798	no	687	0.12223182204425	525	NA	FF|FT	ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS			Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB	protein processing	cysteine-type endopeptidase activity	cellular_component
YMR102C_p	YMR102C	YMR102C	hom	Uncharacterized	1.18874426864114	0.117270157385044	no	688	0.10517515361068	415	NA					Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene	biological_process	molecular_function	cellular_component
YNL193W_p	YNL193W	YNL193W	hom	Uncharacterized	1.18595286398376	0.117820457339017	no	689	0.100665463901572	425	NA					Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis	biological_process	molecular_function	cellular_component
YOR228C	YOR228C	YOR228C	hom	Verified	1.18534633049642	0.117940271146112	no	690	0.120949720124635	458	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to membrane
YBR067C	YBR067C	TIP1	hom	Verified	1.18446095123375	0.118115322478617	no	691	0.108369701210778	409	NA	FT	CELL WALL ORG/BIOGENESIS			Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins	fungal-type cell wall organization	structural constituent of cell wall|lipase activity	fungal-type cell wall
YGR118W	YGR118W	RPS23A	hom	Verified	1.18272120493611	0.118459828708082	no	692	0.12867431787956	454	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity	structural constituent of ribosome	cytosolic small ribosomal subunit
YGL081W_p	YGL081W	YGL081W	hom	Uncharacterized	1.182251227005	0.118553015909041	no	693	0.084732423937816	293	NA					Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis	biological_process	molecular_function	cellular_component
YLR165C	YLR165C	PUS5	hom	Verified	1.1819392012679	0.118614912963673	no	694	0.124758082226739	453	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	MITOCHONDRION		Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability	rRNA modification|pseudouridine synthesis	pseudouridylate synthase activity	mitochondrion
YER068C-A_d	YER068C-A	YER068C-A	hom	Dubious	1.1818202877068	0.118638508049288	no	695	0.111252658759338	375	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR242W	YDR242W	AMD2	hom	Verified	1.18028540918252	0.118943359652013	no	696	0.0757049951274927	288	NA					Putative amidase	biological_process	amidase activity	cellular_component
YGL165C_d	YGL165C	YGL165C	hom	Dubious	1.17861909129941	0.119274943037346	no	697	0.103945127848422	333	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W	Unknown	Unknown	Unknown
YGR042W	YGR042W	YGR042W	hom	Verified	1.17501559711373	0.119994237921847	no	698	0.0934823937839577	367	NA	FT		NUCLEUS		Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YBR174C_d	YBR174C	YBR174C	hom	Dubious	1.17474394073441	0.120048587029154	no	699	0.126747564320114	511	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective	Unknown	Unknown	Unknown
YDL110C	YDL110C	TMA17	hom	Verified	1.17461086959449	0.120075216321764	no	700	0.0991341034736953	370	NA	FT		NUCLEUS		Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YDR048C_d	YDR048C	YDR048C	hom	Dubious	1.17236076326056	0.12052612273985	no	701	0.119394161122697	416	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL151C	YJL151C	SNA3	hom	Verified	1.1712501095692	0.120749129375583	no	702	0.110513045781209	399	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles	cellular protein catabolic process|endosome transport via multivesicular body sorting pathway	ubiquitin protein ligase binding	fungal-type vacuole lumen|integral to membrane
YDL162C_d	YDL162C	YDL162C	hom	Dubious	1.16837787302191	0.12132718811938	no	703	0.116774097200261	431	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly	Unknown	Unknown	Unknown
YHL002W	YHL002W	HSE1	hom	Verified	1.16734046343241	0.121536452005878	no	704	0.133817883619869	420	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes	late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding	endosome|ESCRT-0 complex
YNL134C	YNL134C	YNL134C	hom	Verified	1.1666808207786	0.121669645485983	no	705	0.0970454932009728	348	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress	biological_process	alcohol dehydrogenase (NADP+) activity	nucleus|cytoplasm
YKL143W	YKL143W	LTV1	hom	Verified	1.16623411749233	0.121759900986349	no	706	0.109142079259009	445	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature	ribosomal small subunit biogenesis|cellular response to oxidative stress|response to osmotic stress|ribosomal small subunit export from nucleus	molecular_function	preribosome, small subunit precursor|EGO complex|nucleus|late endosome membrane|cytoplasm
YMR090W_p	YMR090W	YMR090W	hom	Uncharacterized	1.16618230501161	0.121770372637667	no	707	0.134196439174375	463	NA					Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability	biological_process	molecular_function	cytoplasm
YOL150C_d	YOL150C	YOL150C	hom	Dubious	1.16313236566783	0.122387901144706	no	708	0.110123869302884	393	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL227C	YNL227C	JJJ1	hom	Verified	1.16282721949966	0.122449805551598	no	709	0.0963835815343193	360	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION	RIBOSOME	Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis	ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|endocytosis|regulation of cell size|rRNA processing	ATPase activator activity	cytosol|mitochondrion|cytosolic large ribosomal subunit|nucleolus|cytoplasm
YDR153C	YDR153C	ENT5	hom	Verified	1.16248261266997	0.12251974168074	no	710	0.105061827104903	327	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin	late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|Golgi to endosome transport	clathrin binding|phosphatidylinositol-3,5-bisphosphate binding	endosome|clathrin vesicle coat|cytoplasm
YGL118C_d	YGL118C	YGL118C	hom	Dubious	1.15937368309358	0.12315194957258	no	711	0.121891577237152	472	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL129W	YDL129W	YDL129W	hom	Verified	1.15489595991991	0.124066517029159	no	712	0.0864811565047366	304	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YLR360W	YLR360W	VPS38	hom	Verified	1.1542332974385	0.124202267376127	no	713	0.112374836943517	403	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated	ER-associated protein catabolic process|late endosome to vacuole transport	molecular_function	phosphatidylinositol 3-kinase complex II
YCR106W	YCR106W	RDS1	hom	Verified	1.15394466007822	0.124261428928275	no	714	0.108802256518403	504	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide	response to xenobiotic stimulus	sequence-specific DNA binding|DNA binding	nucleus
YAL036C	YAL036C	RBG1	hom	Verified	1.15303711211397	0.124447576039916	no	715	0.128256388736351	467	NA	FT	TRANSLATION		RIBOSOME	Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid	cytoplasmic translation	GTP binding	polysomal ribosome|polysome|cytoplasm
YNL138W	YNL138W	SRV2	hom	Verified	1.15195444453514	0.124669896860944	no	716	0.176375049553826	617	NA	FT	SIGNALING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis	cytoskeleton organization|Ras protein signal transduction	cytoskeletal protein binding|adenylate cyclase binding	mating projection tip|actin cortical patch
YHR127W	YHR127W	YHR127W	hom	Verified	1.15052746345998	0.124963344723381	no	717	0.113947476672817	388	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS		Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis	mitotic spindle elongation	molecular_function	nucleus
YPL188W	YPL188W	POS5	hom	Verified	1.15031951201836	0.125006148612491	no	718	0.125274015207705	498	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress	cellular response to oxidative stress|NADP biosynthetic process	NADH kinase activity	mitochondrion|mitochondrial matrix
YBL008W-A_p	YBL008W-A	YBL008W-A	hom	Uncharacterized	1.14822651755052	0.125437532495436	no	719	0.119022887715398	493	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YHR079C-A	YHR079C-A	SAE3	hom	Verified	1.14668396155917	0.125756130708583	no	720	0.136504342927295	452	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p	double-strand break repair|reciprocal meiotic recombination|meiotic DNA recombinase assembly	molecular_function	condensed nuclear chromosome
YKR095W	YKR095W	MLP1	hom	Verified	1.14658788795456	0.125775992326221	no	721	0.115668415365368	395	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs	protein localization to nuclear pore|poly(A)+ mRNA export from nucleus|protein import into nucleus|transcriptional activation by promoter-terminator looping|nuclear retention of unspliced pre-mRNA at the site of transcription|telomere tethering at nuclear periphery	ribonucleoprotein complex binding	nucleoplasm|nuclear envelope|integral to membrane|ribonucleoprotein complex|spindle pole body
YJL036W	YJL036W	SNX4	hom	Verified	1.1457922445616	0.125940562444077	no	722	0.164302832162165	612	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p	piecemeal microautophagy of nucleus|mitochondrion degradation|early endosome to Golgi transport|CVT pathway|protein targeting to vacuole	phosphatidylinositol-3-phosphate binding	cytosol|pre-autophagosomal structure|extrinsic to membrane|early endosome
YJR011C_p	YJR011C	YJR011C	hom	Uncharacterized	1.14559466080862	0.125981453742327	no	723	0.111962604103923	378	NA					Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cellular_component
YGL218W_d	YGL218W	YGL218W	hom	Dubious	1.14554578938959	0.125991569442043	no	724	0.167405544780084	557	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YDL093W	YDL093W	PMT5	hom	Verified	1.14168550761857	0.126792383465503	no	725	0.132333267374294	425	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals	protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YPL192C	YPL192C	PRM3	hom	Verified	1.14004837847104	0.127133073228306	no	726	0.106814649676857	420	NA	FT	MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body	karyogamy involved in conjugation with cellular fusion|nuclear membrane fusion involved in karyogamy	molecular_function	nuclear envelope|spindle pole body|extrinsic to nuclear outer membrane
YOR019W	YOR019W	YOR019W	hom	Verified	1.13924238865913	0.127301035062614	no	727	0.115946504592796	414	NA	FT	CELL CYCLE			Protein of unknown function that may interact with ribosomes, based on co-purification experiments	mitochondrion degradation	molecular_function	ribosome
YOL117W	YOL117W	RRI2	hom	Verified	1.13902779032271	0.127345781649427	no	728	0.125592267661445	471	NA	FT	SIGNALING	NUCLEUS		Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	molecular_function	signalosome
YMR095C	YMR095C	SNO1	hom	Verified	1.13820195188818	0.127518081920608	no	729	0.0984527661106559	343	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase	pyridoxine metabolic process|thiamine biosynthetic process|anti-apoptosis	molecular_function	cytoplasm
YDR436W	YDR436W	PPZ2	hom	Verified	1.13730366978605	0.12770568058391	no	730	0.120396492737012	424	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular sodium ion homeostasis	protein serine/threonine phosphatase activity	cellular_component
YKR102W	YKR102W	FLO10	hom	Verified	1.13699172454469	0.127770872579172	no	731	0.105739419675962	343	NA					Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth	filamentous growth of a population of unicellular organisms|flocculation via cell wall protein-carbohydrate interaction|flocculation|invasive growth in response to glucose limitation	mannose binding	fungal-type cell wall
YLR354C	YLR354C	TAL1	hom	Verified	1.13592417739349	0.127994149334517	no	732	0.158410898822352	518	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate	pentose-phosphate shunt	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	nucleus|cytoplasm
YBL056W	YBL056W	PTC3	hom	Verified	1.1352344780861	0.128138543523617	no	733	0.118145965871614	466	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication	inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YGL254W	YGL254W	FZF1	hom	Verified	1.13510641441735	0.128165367149135	no	734	0.136125332137366	444	NA	FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS		Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress	positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YGR217W	YGR217W	CCH1	hom	Verified	1.13327793004284	0.128548778431358	no	735	0.124756657792061	424	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together	calcium ion transport	voltage-gated calcium channel activity|calcium channel activity	integral to membrane|plasma membrane
YLR405W	YLR405W	DUS4	hom	Verified	1.13275981098619	0.128657566388954	no	736	0.117289913102658	413	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS			Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p	tRNA modification	tRNA dihydrouridine synthase activity	cellular_component
YGR062C	YGR062C	COX18	hom	Verified	1.13211177726246	0.128793722049711	no	737	0.129351158757959	491	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC	protein insertion into mitochondrial membrane from inner side	membrane insertase activity	integral to membrane|integral to mitochondrial inner membrane
YGL088W_d	YGL088W	YGL088W	hom	Dubious	1.13196639045996	0.128824282387499	no	738	0.132131773650255	457	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing	Unknown	Unknown	Unknown
YDR349C	YDR349C	YPS7	hom	Verified	1.1314725511418	0.128928125080499	no	739	0.126598853197105	476	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum	fungal-type cell wall organization	aspartic-type endopeptidase activity	endoplasmic reticulum|cytoplasm
YDL023C_d	YDL023C	YDL023C	hom	Dubious	1.13104819925848	0.1290174025786	no	740	0.141031233459734	521	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YOL085C_d	YOL085C	YOL085C	hom	Dubious	1.1292325058667	0.129399882287951	no	741	0.127852539387851	437	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A	Unknown	Unknown	Unknown
YGL160W	YGL160W	AIM14	hom	Verified	1.12913279534502	0.129420909258856	no	742	0.128758720919897	461	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p	biological_process	oxidoreductase activity, oxidizing metal ions	integral to membrane|ribosome
YMR326C_d	YMR326C	YMR326C	hom	Dubious	1.12662105763104	0.129951366029392	no	743	0.125278507858822	451	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13	Unknown	Unknown	Unknown
YOR267C	YOR267C	HRK1	hom	Verified	1.12536174903517	0.130217886560438	no	744	0.0890484368717084	313	NA	FT	ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS			Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress	protein phosphorylation|cellular ion homeostasis	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YLR237W	YLR237W	THI7	hom	Verified	1.12466024907676	0.130366516180293	no	745	0.154904684548889	489	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia	thiamine transport	thiamine transmembrane transporter activity	integral to membrane|plasma membrane
YDL231C	YDL231C	BRE4	hom	Verified	1.12450285771597	0.130399879433116	no	746	0.133152197314006	461	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport	endocytosis	molecular_function	integral to membrane
YML106W	YML106W	URA5	hom	Verified	1.12444851915237	0.130411399297121	no	747	0.125738788566849	443	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication	'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process	orotate phosphoribosyltransferase activity	nucleus|cytoplasm
YBR205W	YBR205W	KTR3	hom	Verified	1.12418092647463	0.130468139649217	no	748	0.0846593486255353	322	NA	FT	CARBOHYDRATE METABOLISM			Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress	N-glycan processing|protein O-linked glycosylation	mannosyltransferase activity	fungal-type vacuole
YOL019W-A_p	YOL019W-A	YOL019W-A	hom	Uncharacterized	1.12329088017875	0.130656987895812	no	749	0.111003228237511	379	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YFL028C	YFL028C	CAF16	hom	Verified	1.12293363949554	0.130732839634735	no	750	0.118697706724737	427	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator	regulation of transcription from RNA polymerase II promoter	ATPase activity	CCR4-NOT complex|cytoplasm
YNR028W	YNR028W	CPR8	hom	Verified	1.12259680329158	0.130804386834422	no	751	0.112313743502305	381	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	fungal-type vacuole
YPL215W	YPL215W	CBP3	hom	Verified	1.12235609016288	0.130855533160727	no	752	0.105612047249601	427	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly	ribosome binding	integral to mitochondrial membrane|mitochondrion|mitochondrial ribosome
YEL010W_d	YEL010W	YEL010W	hom	Dubious	1.12204961334578	0.130920672845626	no	753	0.0958607291243133	371	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR127W	YPR127W	YPR127W	hom	Verified	1.12061899856445	0.131225037262672	no	754	0.122400506194807	476	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YPR050C_d	YPR050C	YPR050C	hom	Dubious	1.12043299816685	0.13126464486279	no	755	0.169215015680855	599	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W	Unknown	Unknown	Unknown
YJL157C	YJL157C	FAR1	hom	Verified	1.11859494916332	0.131656489605855	no	756	0.0886110823086751	360	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH		Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress	maintenance of protein location in nucleus|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell cycle arrest in response to pheromone	cyclin-dependent protein kinase inhibitor activity	nucleus|mating projection tip|membrane|cytoplasm
YPR078C_p	YPR078C	YPR078C	hom	Uncharacterized	1.11668303075017	0.132064937956852	no	757	0.111288078498119	452	NA					Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible	biological_process	molecular_function	cellular_component
YJR092W	YJR092W	BUD4	hom	Verified	1.11589300260667	0.132233968693935	no	758	0.115270690281796	390	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p	cellular bud site selection|axial cellular bud site selection	GTP binding	cellular bud neck contractile ring
YLR126C	YLR126C	YLR126C	hom	Verified	1.11585118783738	0.132242919340842	no	759	0.120482691149775	450	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS			Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	cellular copper ion homeostasis|cellular iron ion homeostasis	molecular_function	cytoplasm
YLR177W_p	YLR177W	YLR177W	hom	Uncharacterized	1.11423395356213	0.13258941637453	no	760	0.128364554141035	410	NA					Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YDR098C	YDR098C	GRX3	hom	Verified	1.1131555703366	0.132820810320575	no	761	0.117667401196456	401	NA	FT	ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36	cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization	disulfide oxidoreductase activity	cytosol|nucleus
YLR248W	YLR248W	RCK2	hom	Verified	1.11204991845062	0.133058344001434	no	762	0.139169960269875	488	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS			Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication	cellular response to oxidative stress|protein phosphorylation|osmosensory signaling pathway|regulation of meiosis	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YML067C	YML067C	ERV41	hom	Verified	1.11105357572307	0.133272644480007	no	763	0.134302990806045	482	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein	ER to Golgi vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YGR025W_d	YGR025W	YGR025W	hom	Dubious	1.10811600071667	0.133905860761692	no	764	0.102319236973287	342	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YFR006W_p	YFR006W	YFR006W	hom	Uncharacterized	1.107924311821	0.133947252481517	no	765	0.126346106397533	464	NA					Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene	biological_process	molecular_function	cytoplasm
YBL086C_p	YBL086C	YBL086C	hom	Uncharacterized	1.10717387395022	0.134109380431697	no	766	0.114133672433966	369	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YML102W	YML102W	CAC2	hom	Verified	1.10694306857454	0.134159271752897	no	767	0.136772458826919	482	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription	DNA replication-dependent nucleosome assembly	histone binding	chromosome, centromeric region|CAF-1 complex
YKR039W	YKR039W	GAP1	hom	Verified	1.10603955187945	0.134354700246857	no	768	0.134270080326777	443	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	PLASMA MEMBRANE		General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth	amino acid transport|gamma-aminobutyric acid transport|ammonia assimilation cycle|polyamine transport	amino acid transmembrane transporter activity|polyamine transmembrane transporter activity|L-proline transmembrane transporter activity	endosome|fungal-type vacuole lumen|integral to membrane|plasma membrane|ER to Golgi transport vesicle|integral to plasma membrane|multivesicular body
YML107C	YML107C	PML39	hom	Verified	1.10578552408488	0.1344096810387	no	769	0.123984275302175	411	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes	maintenance of RNA location	molecular_function	ribosome|nuclear pore
YMR004W	YMR004W	MVP1	hom	Verified	1.10527251886427	0.134520760996476	no	770	0.150676150769375	521	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	NUCLEUS		Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress	protein targeting to vacuole	phosphatidylinositol-3-phosphate binding	nucleus|cytoplasm
YDL037C	YDL037C	BSC1	hom	Verified	1.10500239827422	0.134579274968012	no	771	0.138061235790971	493	NA					Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression	biological_process	molecular_function	cellular_component
YMR132C_p	YMR132C	JLP2	hom	Uncharacterized	1.10383902719754	0.134831485981938	no	772	0.100090600829418	347	NA					Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)	biological_process	molecular_function	cytoplasm
YMR063W	YMR063W	RIM9	hom	Verified	1.10155078425368	0.135328507347866	no	773	0.192041401114815	697	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;	ascospore formation	molecular_function	integral to membrane
YLR263W	YLR263W	RED1	hom	Verified	1.0975749542166	0.136195067193255	no	774	0.110137156320482	394	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p	synaptonemal complex assembly|meiotic recombination checkpoint|positive regulation of catalytic activity	chromatin DNA binding|structural molecule activity	lateral element
YKL132C	YKL132C	RMA1	hom	Verified	1.09582581098977	0.136577505362208	no	775	0.117310248801921	375	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	tetrahydrofolylpolyglutamate synthase activity	mitochondrion
YMR180C	YMR180C	CTL1	hom	Verified	1.09479535305684	0.136803151366278	no	776	0.120678638526765	427	NA	FT	RNA PROCESSING	NUCLEUS		RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm	biological_process	polynucleotide 5'-phosphatase activity	nucleus|cytoplasm
YOR024W_d	YOR024W	YOR024W	hom	Dubious	1.09267341811107	0.137268607432349	no	777	0.135949416722454	417	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL034C_d	YGL034C	YGL034C	hom	Dubious	1.09252737900399	0.137300681508074	no	778	0.153623127264343	508	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER041W	YER041W	YEN1	hom	Verified	1.09229317330186	0.137352130000475	no	779	0.130181515979551	509	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p	DNA repair|response to DNA damage stimulus	single-stranded DNA specific endodeoxyribonuclease activity|crossover junction endodeoxyribonuclease activity	nucleus|cytoplasm
YNL119W	YNL119W	NCS2	hom	Verified	1.0919551311316	0.137426411694159	no	780	0.132358090560214	470	NA	FT	RNA PROCESSING			Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	tRNA wobble position uridine thiolation|pseudohyphal growth|protein urmylation|invasive growth in response to glucose limitation	molecular_function	cytosol|cytoplasm
YHR016C	YHR016C	YSC84	hom	Verified	1.09063361441164	0.137717066161119	no	781	0.143039641958481	517	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication	endocytosis|actin filament organization|actin filament bundle assembly|actin cortical patch localization|actin cytoskeleton organization	actin filament binding	actin cortical patch
YLR144C	YLR144C	ACF2	hom	Verified	1.08942509943155	0.137983233997712	no	782	0.134150963158454	484	NA	FT	CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION			Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress	actin cytoskeleton organization	glucan endo-1,3-beta-D-glucosidase activity	intracellular
YOL140W	YOL140W	ARG8	hom	Verified	1.08898598066467	0.138080034001182	no	783	0.118340906240376	403	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine	arginine biosynthetic process|ornithine biosynthetic process	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	mitochondrion|mitochondrial matrix
YOL115W	YOL115W	PAP2	hom	Verified	1.08864602710324	0.138155005674026	no	784	0.153385944379076	563	NA	FT	CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION	NUCLEUS		Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p	polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|base-excision repair|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U4 snRNA 3'-end processing|nuclear mRNA surveillance of mRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation|tRNA modification	5'-deoxyribose-5-phosphate lyase activity|polynucleotide adenylyltransferase activity	nucleolus|nucleus|TRAMP complex
YGR261C	YGR261C	APL6	hom	Verified	1.08755053003913	0.138396789978082	no	785	0.168629752259783	606	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools	vesicle-mediated transport|Golgi to vacuole transport	molecular_function	AP-3 adaptor complex
YOL105C	YOL105C	WSC3	hom	Verified	1.08672127278262	0.138580004857126	no	786	0.12092649402658	473	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH		Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis	response to heat|peroxisome degradation|Rho protein signal transduction	transmembrane signaling receptor activity	mating projection tip
YGR177C	YGR177C	ATF2	hom	Verified	1.08625827789729	0.138682370123516	no	787	0.119780010818485	417	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking	steroid metabolic process|response to toxin|Unknown|sterol acetylation	alcohol O-acetyltransferase activity	integral to endoplasmic reticulum membrane|endoplasmic reticulum|cytoplasm
YOR233W	YOR233W	KIN4	hom	Verified	1.08604703212839	0.138729092346076	no	788	0.119387106963293	464	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication	mitotic cell cycle spindle orientation checkpoint|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cell cortex|spindle pole body|cellular bud neck
YDR490C	YDR490C	PKH1	hom	Verified	1.08510498798204	0.138937579197088	no	789	0.122913465880503	458	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION			Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p	regulation of nuclear-transcribed mRNA poly(A) tail shortening|endocytosis|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly	protein kinase activity	cytosol|cell cortex|eisosome
YPR199C	YPR199C	ARR1	hom	Verified	1.08406341152521	0.139168342079415	no	790	0.125592581785354	471	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds	positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YNL087W	YNL087W	TCB2	hom	Verified	1.0830013523006	0.139403911401386	no	791	0.143414866335505	511	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud	biological_process	lipid binding	cellular bud|cortical endoplasmic reticulum
YKL091C	YKL091C	YKL091C	hom	Verified	1.08238866871368	0.139539930574946	no	792	0.143808235400583	506	NA	FT		NUCLEUS		Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study	biological_process	phosphatidylcholine binding|phosphatidylinositol transporter activity|phosphatidylinositol binding|phosphatidylcholine transporter activity	nucleus
YDR415C_p	YDR415C	YDR415C	hom	Uncharacterized	1.08147171363468	0.139743668296425	no	793	0.111967383505503	397	NA	FT	PROTEOLYSIS			Putative aminopeptidase	biological_process	molecular_function	cellular_component
YOL006C	YOL006C	TOP1	hom	Verified	1.0802258320711	0.140020813919829	no	794	0.145549143575976	518	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination	nuclear migration|chromatin assembly or disassembly|DNA topological change|DNA strand elongation involved in DNA replication|regulation of mitotic recombination|chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|mitotic chromosome condensation|transcription elongation from RNA polymerase II promoter	DNA topoisomerase type I activity	replication fork protection complex|nucleolus|nucleus
YMR068W	YMR068W	AVO2	hom	Verified	1.08013828984903	0.140040301669367	no	795	0.148292618798678	525	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth	fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity	molecular_function	TORC2 complex|cytoplasm
YBR052C	YBR052C	RFS1	hom	Verified	1.07826833215116	0.140457012565071	no	796	0.0964374556226937	403	NA	FT	OXIDATION-REDUCTION PROCESS			Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication	biological_process	molecular_function	membrane raft|cytoplasm
YNR064C	YNR064C	YNR064C	hom	Verified	1.07819941831101	0.140472385743844	no	797	0.133495818723622	560	NA					Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides	response to toxin	epoxide hydrolase activity	cellular_component
YLR096W	YLR096W	KIN2	hom	Verified	1.07753067613931	0.140621626905491	no	798	0.145541869193374	508	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	PLASMA MEMBRANE		Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p	protein autophosphorylation|exocytosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	plasma membrane
YPL019C	YPL019C	VTC3	hom	Verified	1.07253459593854	0.141739991785019	no	799	0.113514423690692	415	NA	FT	MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion	polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane|integral to membrane|vacuolar transporter chaperone complex|endoplasmic reticulum
YDR358W	YDR358W	GGA1	hom	Verified	1.07231818465239	0.141788570865015	no	800	0.122525245263731	428	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi	Golgi to vacuole transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to endosome transport	ubiquitin binding	trans-Golgi network
YPL200W	YPL200W	CSM4	hom	Verified	1.07014805965381	0.14227633469934	no	801	0.142684320772893	506	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|CHROMOSOME		Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements	meiotic telomere clustering|meiotic chromosome segregation|synapsis|regulation of reciprocal meiotic recombination	molecular_function	nuclear chromosome, telomeric region|endoplasmic reticulum membrane
YLR025W	YLR025W	SNF7	hom	Verified	1.07013027397614	0.142280336946752	no	802	0.224487780886919	806	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes	cellular response to anoxia|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	protein binding	ESCRT III complex|cytoplasm
YIR001C	YIR001C	SGN1	hom	Verified	1.07010897203912	0.142285130545683	no	803	0.138722405234549	492	NA					Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation	mRNA metabolic process	poly(A) RNA binding	cytoplasm
YGL164C	YGL164C	YRB30	hom	Verified	1.06675079014188	0.143042192682007	no	804	0.139161655343169	494	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes	biological_process	GTPase regulator activity	nucleus|cytoplasm
YPL034W_p	YPL034W	YPL034W	hom	Uncharacterized	1.06542077145344	0.143342780605977	no	805	0.156464880031621	551	NA					Putative protein of unknown function; YPL034W is not essential gene	biological_process	molecular_function	cellular_component
YPL136W_d	YPL136W	YPL136W	hom	Dubious	1.06517678857885	0.143397967679938	no	806	0.155317829363964	561	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C	Unknown	Unknown	Unknown
YBL028C	YBL028C	YBL028C	hom	Verified	1.06513165105255	0.143408179018023	no	807	0.165941913723117	505	NA	FT		NUCLEUS		Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YPR097W	YPR097W	YPR097W	hom	Verified	1.06452812889543	0.143544759339291	no	808	0.160868181169691	591	NA	FT		MITOCHONDRION		Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	phosphatidylinositol binding	mitochondrion
YMR011W	YMR011W	HXT2	hom	Verified	1.06442936500559	0.143567118497851	no	809	0.141643987244597	535	NA	FT		PLASMA MEMBRANE		High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose	glucose transport	pentose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YOR027W	YOR027W	STI1	hom	Verified	1.06420819966585	0.143617196648453	no	810	0.150246902564449	539	NA					Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop	protein folding	Hsp70 protein binding|Hsp90 protein binding|mRNA binding|ATPase inhibitor activity	cytoplasm
YMR252C_p	YMR252C	YMR252C	hom	Uncharacterized	1.06405774870978	0.143651269779619	no	811	0.124632798805013	483	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene	biological_process	molecular_function	mitochondrion
YJL158C	YJL158C	CIS3	hom	Verified	1.06281548613977	0.143932817626628	no	812	0.126619400799745	442	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family	fungal-type cell wall organization	structural constituent of cell wall	extracellular region|fungal-type cell wall|endoplasmic reticulum|plasma membrane|cellular bud tip
YBR223C	YBR223C	TDP1	hom	Verified	1.06181264116921	0.1441603749318	no	813	0.156093418503227	561	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI	DNA repair	3'-tyrosyl-DNA phosphodiesterase activity|5'-tyrosyl-DNA phosphodiesterase activity	nucleus
YNR030W	YNR030W	ALG12	hom	Verified	1.05984346987497	0.144607908467833	no	814	0.172899176759967	570	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation	dolichol-linked oligosaccharide biosynthetic process|protein glycosylation	alpha-1,6-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YML003W_p	YML003W	YML003W	hom	Uncharacterized	1.05771266341883	0.145093230084071	no	815	0.125571370743166	424	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOL019W_p	YOL019W	YOL019W	hom	Uncharacterized	1.05767628512423	0.145101525266872	no	816	0.158194253497717	535	NA	FT		PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; YOL019W has a paralog, DCV1, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane|plasma membrane|fungal-type vacuole
YNL045W	YNL045W	LAP2	hom	Verified	1.05455353402914	0.145814782275299	no	817	0.130467955450862	445	NA	FT	KETONE METABOLISM|LIPID METABOLISM|PROTEOLYSIS	NUCLEUS		Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	cellular lipid metabolic process|protein catabolic process	aminopeptidase activity|leukotriene-A4 hydrolase activity|epoxide hydrolase activity	nucleus|cytoplasm
YBR046C	YBR046C	ZTA1	hom	Verified	1.05420262030563	0.145895080321856	no	818	0.150179818673253	519	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin	cellular response to oxidative stress	NADPH:quinone reductase activity|AU-rich element binding|2-alkenal reductase [NAD(P)] activity	nucleus|cytoplasm
YDR264C	YDR264C	AKR1	hom	Verified	1.05363295179113	0.146025498332262	no	819	0.258419828150614	901	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication	protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation	palmitoyltransferase activity	integral to membrane|Golgi apparatus|membrane
YLR285C-A_p	YLR285C-A	YLR285C-A	hom	Uncharacterized	1.05274196529742	0.146229634820022	no	820	0.132410509113709	455	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YOR161C-C_p	YOR161C-C	YOR161C-C	hom	Uncharacterized	1.05217226696792	0.146360260450826	no	821	0.121002194842801	428	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YPR135W	YPR135W	CTF4	hom	Verified	1.05209746902156	0.146377416623066	no	822	0.19604978558404	703	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion	DNA repair|replicative cell aging|double-strand break repair via break-induced replication|DNA replication initiation|DNA-dependent DNA replication|mitotic sister chromatid cohesion	chromatin binding|DNA binding	nuclear chromosome|replication fork protection complex|nuclear replication fork|nucleus
YKL116C	YKL116C	PRR1	hom	Verified	1.05099914371212	0.14662949155809	no	823	0.105696357681982	387	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION			Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor	negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation	protein kinase activity|receptor signaling protein serine/threonine kinase activity	cytoplasm
YPR011C_p	YPR011C	YPR011C	hom	Uncharacterized	1.05046444780888	0.146752314152808	no	824	0.112836021829491	408	NA	FT		MITOCHONDRION		Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	transport	transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YER067C-A_d	YER067C-A	YER067C-A	hom	Dubious	1.05025106352473	0.146801348962644	no	825	0.114719034160559	384	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W	Unknown	Unknown	Unknown
YDR300C	YDR300C	PRO1	hom	Verified	1.04954355005034	0.146964011212766	no	826	0.151264874616737	506	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication	proline biosynthetic process	glutamate 5-kinase activity	cytoplasm
YML061C	YML061C	PIF1	hom	Verified	1.04840031904167	0.147227103313356	no	827	0.173666609474025	599	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION		DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells	chromosome organization|negative regulation of telomere maintenance via telomerase|telomere maintenance|mitochondrial genome maintenance|DNA recombination	DNA helicase activity|telomerase inhibitor activity	mitochondrion|nucleus|mitochondrial membrane
YPR096C	YPR096C	YPR096C	hom	Verified	1.04819361258417	0.147274706414529	no	828	0.127380812498984	456	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments	biological_process	molecular_function	ribosome
YHR158C	YHR158C	KEL1	hom	Verified	1.04771391793643	0.147385216597645	no	829	0.143318599215407	508	NA	FT	CELL CYCLE|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH		Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate	negative regulation of exit from mitosis|regulation of cell shape|cell morphogenesis|cytogamy|plasma membrane fusion	molecular_function	mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YNL108C_p	YNL108C	YNL108C	hom	Uncharacterized	1.04729628880643	0.147481473606192	no	830	0.169869851598083	613	NA	FT		NUCLEUS		Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YGR058W	YGR058W	PEF1	hom	Verified	1.04095602587148	0.148947978786167	no	831	0.13350201350215	487	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH		Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly	bipolar cellular bud site selection|regulation of COPII vesicle coating|axial cellular bud site selection	zinc ion binding|calcium ion binding	cytosol|site of polarized growth|nucleus|cellular bud neck|cytoplasm
YKL138C	YKL138C	MRPL31	hom	Verified	1.03998484069111	0.149173471820789	no	832	0.171221528605153	611	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrial large ribosomal subunit
YJL051W	YJL051W	IRC8	hom	Verified	1.03529219835522	0.150266236087234	no	833	0.119375376751451	436	NA					Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc	mitotic recombination	molecular_function	integral to membrane|cellular bud
YBR170C	YBR170C	NPL4	hom	Verified	1.03163221311141	0.151122221927342	no	834	0.153592271994441	517	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)	retrograde protein transport, ER to cytosol|proteasomal ubiquitin-dependent protein catabolic process|mitochondria-associated protein catabolic process|mitotic spindle disassembly|ER-associated protein catabolic process|ER-associated misfolded protein catabolic process|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process	molecular_function	Doa10p ubiquitin ligase complex|integral to membrane|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|Cdc48p-Npl4p-Vms1p AAA ATPase complex|nuclear outer membrane-endoplasmic reticulum membrane network
YCR068W	YCR068W	ATG15	hom	Verified	1.02866339756439	0.151818937731011	no	835	0.176532770875291	626	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway	membrane disassembly|autophagy|piecemeal microautophagy of nucleus|vacuolar protein processing|multivesicular body membrane disassembly	lipase activity	integral to membrane|vacuolar lumen
YCR024C	YCR024C	SLM5	hom	Verified	1.02706964065043	0.152193836495926	no	836	0.178205095257541	631	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial asparaginyl-tRNA synthetase	asparaginyl-tRNA aminoacylation|mitochondrial asparaginyl-tRNA aminoacylation	asparagine-tRNA ligase activity	mitochondrion
YMR251W	YMR251W	GTO3	hom	Verified	1.02697604967379	0.152215870953467	no	837	0.163389102400645	542	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Omega class glutathione transferase; putative cytosolic localization	glutathione metabolic process	glutathione transferase activity	cytoplasm
YBR129C	YBR129C	OPY1	hom	Verified	1.02681796733423	0.152253093652623	no	838	0.117334213340453	406	NA	FT		MITOCHONDRION		Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YJR107W_p	YJR107W	YJR107W	hom	Uncharacterized	1.0250479074173	0.152670291662958	no	839	0.143169570084514	489	NA	FT	LIPID METABOLISM			Putative lipase	biological_process	lipase activity	cellular_component
YLR205C	YLR205C	HMX1	hom	Verified	1.0249701198196	0.152688643354158	no	840	0.121550692088876	432	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants	response to oxidative stress|cellular iron ion homeostasis|heme catabolic process	heme oxygenase (decyclizing) activity	endoplasmic reticulum|membrane|nuclear outer membrane
YER037W	YER037W	PHM8	hom	Verified	1.02295794188016	0.153163865929111	no	841	0.154279045095498	560	NA	FT	RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p	cellular response to phosphate starvation	lysophosphatidic acid phosphatase activity	nucleus|cytoplasm
YKR069W	YKR069W	MET1	hom	Verified	1.02277107493654	0.153208048588816	no	842	0.153783499451846	524	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis	siroheme biosynthetic process|methionine biosynthetic process|sulfate assimilation	uroporphyrin-III C-methyltransferase activity	intracellular
YAL024C	YAL024C	LTE1	hom	Verified	1.02242071617587	0.153290909873783	no	843	0.209636278910701	730	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION			Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint|vesicle-mediated transport	guanyl-nucleotide exchange factor activity	cellular bud
YNL319W_d	YNL319W	YNL319W	hom	Dubious	1.02193232432507	0.153406466086824	no	844	0.168058148938086	588	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14	Unknown	Unknown	Unknown
YLR095C	YLR095C	IOC2	hom	Verified	1.0203906933771	0.153771602949514	no	845	0.150811420667132	524	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif	chromatin remodeling	protein binding|nucleosome binding|ATPase activity|DNA binding	ISW1 complex
YBR176W	YBR176W	ECM31	hom	Verified	1.02008074738687	0.153845083375793	no	846	0.161528587018871	477	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate	pantothenate biosynthetic process	3-methyl-2-oxobutanoate hydroxymethyltransferase activity	mitochondrion
YLR174W	YLR174W	IDP2	hom	Verified	1.01985387549464	0.153898883744233	no	847	0.127502397730026	454	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication	glutamate biosynthetic process|isocitrate metabolic process	isocitrate dehydrogenase (NADP+) activity	cytosol
YJL181W_p	YJL181W	YJL181W	hom	Uncharacterized	1.01912648881956	0.154071460062908	no	848	0.11349553781425	412	NA					Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDL081C	YDL081C	RPP1A	hom	Verified	1.01864597229659	0.154185535334382	no	849	0.149820662198762	522	NA	FT	TRANSLATION		RIBOSOME	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component	cytoplasmic translation|translational elongation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR394W	YLR394W	CST9	hom	Verified	1.01853248084128	0.154212486512491	no	850	0.150365147206647	485	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate	synaptonemal complex assembly|protein sumoylation|synapsis|reciprocal meiotic recombination	SUMO ligase activity	condensed nuclear chromosome|nuclear chromosome
YCR051W_p	YCR051W	YCR051W	hom	Uncharacterized	1.01704312935633	0.154566456285039	no	851	0.153302556198548	563	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YDR233C	YDR233C	RTN1	hom	Verified	1.01494611880981	0.155065756223794	no	852	0.133819850613113	488	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication	endoplasmic reticulum tubular network organization|endoplasmic reticulum organization|endoplasmic reticulum tubular network maintenance|nuclear pore complex assembly	molecular_function	integral to endoplasmic reticulum membrane|mitochondrion|Golgi apparatus|endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YOL152W	YOL152W	FRE7	hom	Verified	1.01471997428636	0.155119664967728	no	853	0.158242304337162	552	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YBR203W	YBR203W	COS111	hom	Verified	1.01315152710944	0.155493894737335	no	854	0.194148358572538	656	NA	FT	SIGNALING	MITOCHONDRION		Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	signal transduction	molecular_function	mitochondrion
YJR024C	YJR024C	MDE1	hom	Verified	1.01149943720464	0.155888725175826	no	855	0.141895459625322	474	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant	L-methionine salvage from methylthioadenosine	methylthioribulose 1-phosphate dehydratase activity	cytoplasm
YDR169C	YDR169C	STB3	hom	Verified	1.01069141624471	0.156082073332643	no	856	0.134052213673363	457	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter by glucose	sequence-specific DNA binding	nucleus|cytoplasm
YBR076W	YBR076W	ECM8	hom	Verified	1.01028833519008	0.156178584067318	no	857	0.163747820485141	524	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function	fungal-type cell wall organization	molecular_function	cellular_component
YKL128C	YKL128C	PMU1	hom	Verified	1.00780716246045	0.15677352337354	no	858	0.119018298240146	430	NA	FT		NUCLEUS		Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant	biological_process	molecular_function	nucleus|cytoplasm
YEL031W	YEL031W	SPF1	hom	Verified	1.00607783528508	0.15718906490571	no	859	0.223198998784228	787	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1	cellular calcium ion homeostasis|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	mitochondrion|integral to membrane|endoplasmic reticulum membrane|cis-Golgi network
YIL079C	YIL079C	AIR1	hom	Verified	1.00547402840013	0.157334324620152	no	860	0.161486968776498	553	NA	FT	RNA PROCESSING	NUCLEUS		Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication	nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent snRNA catabolic process	polynucleotide adenylyltransferase activity	nucleolus|TRAMP complex
YJR103W	YJR103W	URA8	hom	Verified	1.00447070775496	0.157575891690828	no	861	0.12774913215904	398	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication	pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process	CTP synthase activity	cytosol
YDR063W	YDR063W	AIM7	hom	Verified	1.00315101684913	0.157894001351946	no	862	0.136203790811044	465	NA	FT	CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss	actin filament debranching|negative regulation of Arp2/3 complex-mediated actin nucleation	molecular_function	nucleus|actin cortical patch|cytoplasm
YMR189W	YMR189W	GCV2	hom	Verified	1.00265042818523	0.158014777796488	no	863	0.127325018166393	478	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm	glycine decarboxylation via glycine cleavage system|one-carbon metabolic process	glycine dehydrogenase (decarboxylating) activity	mitochondrion|glycine cleavage complex
YJL095W	YJL095W	BCK1	hom	Verified	0.999995032551237	0.158656455911619	no	864	0.253200177200987	913	NA	FF|FT	SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH		Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p	intracellular protein kinase cascade|endoplasmic reticulum unfolded protein response|peroxisome degradation|establishment of cell polarity|protein phosphorylation|response to acid|response to nutrient	protein kinase activity|MAP kinase kinase kinase activity	intracellular|mating projection tip
YGL119W	YGL119W	COQ8	hom	Verified	0.999889976381126	0.158681877890782	no	865	0.167445923779039	574	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication	ubiquinone biosynthetic process|aerobic respiration	molecular_function	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial matrix
YPR155C	YPR155C	NCA2	hom	Verified	0.999789394035634	0.158706219775533	no	866	0.137983348180977	489	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p	mRNA metabolic process|aerobic respiration	molecular_function	mitochondrial outer membrane|mitochondrion
YDR402C	YDR402C	DIT2	hom	Verified	0.999264101933463	0.158833385238918	no	867	0.170817146758417	575	NA	FT	CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS			N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s	ascospore wall assembly	oxidoreductase activity	cellular_component
YMR035W	YMR035W	IMP2	hom	Verified	0.995617793962685	0.159717942864057	no	868	0.12825987394384	468	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	protein processing involved in protein targeting to mitochondrion	endopeptidase activity	mitochondrial inner membrane peptidase complex
YPR118W	YPR118W	MRI1	hom	Verified	0.995396020989193	0.159771846540385	no	869	0.17197144636543	543	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway	L-methionine salvage from methylthioadenosine	S-methyl-5-thioribose-1-phosphate isomerase activity	nucleus|cytoplasm
YNR044W	YNR044W	AGA1	hom	Verified	0.995374213365757	0.159777147698498	no	870	0.114281575106023	412	NA					Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YEL007W	YEL007W	MIT1	hom	Verified	0.995181423397441	0.159824017512717	no	871	0.136420932133843	492	NA	FT		NUCLEUS		Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1	biological_process	molecular_function	nucleus|cytoplasm
YML103C	YML103C	NUP188	hom	Verified	0.994691393975381	0.159943190685928	no	872	0.14698697179732	527	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188	nuclear pore organization|protein import into nucleus|mRNA export from nucleus in response to heat stress	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YKL168C	YKL168C	KKQ8	hom	Verified	0.99454558299518	0.159978662543042	no	873	0.142717024104954	487	NA	FT	PROTEIN PHOSPHORYLATION			Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication	biological_process	protein kinase activity	cytoplasm
YER039C	YER039C	HVG1	hom	Verified	0.993913411773377	0.160132512157822	no	874	0.162227052156637	562	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein of unknown function, has homology to Vrg4p	biological_process	molecular_function	integral to membrane
YNL024C_p	YNL024C	YNL024C	hom	Uncharacterized	0.993036649568679	0.160346047201329	no	875	0.161699238416802	579	NA					Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cytoplasm
YDR298C	YDR298C	ATP5	hom	Verified	0.992622708711001	0.160446926948818	no	876	0.174734742293721	613	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, stator stalk|mitochondrial proton-transporting ATP synthase complex
YGL136C	YGL136C	MRM2	hom	Verified	0.992505651698096	0.160475461930064	no	877	0.128733068299793	445	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	MITOCHONDRION		Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ	rRNA methylation	rRNA (uridine-2'-O-)-methyltransferase activity	mitochondrion
YLL013C	YLL013C	PUF3	hom	Verified	0.992208148767719	0.160547999122756	no	878	0.156223766063253	540	NA	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|RNA LOCALIZATION	MITOCHONDRION		Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process|intracellular mRNA localization|mitochondrion organization|aerobic respiration|mitochondrion localization	mRNA binding	external side of mitochondrial outer membrane|cytoplasm
YJR130C	YJR130C	STR2	hom	Verified	0.992079917687075	0.160579271041473	no	879	0.150933966539854	525	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Cystathionine gamma-synthase, converts cysteine into cystathionine	sulfur compound metabolic process|transsulfuration	cystathionine gamma-synthase activity	nucleus|cytoplasm
YPL187W	YPL187W	MF(ALPHA)1	hom	Verified	0.989747201473514	0.161148848762462	no	880	0.163729336010808	570	NA	FT	SIGNALING			Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YBL022C	YBL022C	PIM1	hom	Verified	0.988838185829449	0.161371158973481	no	881	0.207954340786618	705	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria	chaperone-mediated protein complex assembly|misfolded or incompletely synthesized protein catabolic process	ATP-dependent peptidase activity	mitochondrion|mitochondrial matrix
YNL066W	YNL066W	SUN4	hom	Verified	0.988180151199363	0.161532213637837	no	882	0.171708833369292	569	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family	mitochondrion organization	glucosidase activity	fungal-type cell wall|mitochondrial matrix
YBR241C_p	YBR241C	YBR241C	hom	Uncharacterized	0.986073207615363	0.162048594996354	no	883	0.105302811105467	383	NA					Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene	transport|transmembrane transport	substrate-specific transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|membrane
YNL214W	YNL214W	PEX17	hom	Verified	0.98573693969593	0.162131108773989	no	884	0.179308276841599	615	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis	protein import into peroxisome matrix, docking	protein binding	peroxisomal membrane
YHR080C	YHR080C	YHR080C	hom	Verified	0.984583819404354	0.162414270391849	no	885	0.170174904933305	624	NA	FT		MITOCHONDRION		Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|ribosome
YLR168C	YLR168C	UPS2	hom	Verified	0.984475772878014	0.162440818910218	no	886	0.162133925275807	600	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI	cristae formation|Unknown|phosphatidylethanolamine metabolic process|cardiolipin metabolic process	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YJR052W	YJR052W	RAD7	hom	Verified	0.984119754941853	0.162528317400095	no	887	0.159132648988122	532	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	damaged DNA binding|ubiquitin-protein ligase activity|DNA-dependent ATPase activity	nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YKR028W	YKR028W	SAP190	hom	Verified	0.983806856249551	0.162605243794255	no	888	0.162173472081329	575	NA	FT	CELL CYCLE|RNA PROCESSING|SIGNALING			Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication	TOR signaling cascade|dephosphorylation|G1/S transition of mitotic cell cycle|tRNA wobble uridine modification	molecular_function	cytoplasm
YLL058W_p	YLL058W	YLL058W	hom	Uncharacterized	0.983716206122423	0.162627534625328	no	889	0.153816147375448	539	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene	sulfur compound metabolic process	cystathionine gamma-synthase activity	cellular_component
YDR135C	YDR135C	YCF1	hom	Verified	0.983598663488161	0.162656441273373	no	890	0.139185473876128	494	NA	FT	NUCLEOTIDE METABOLISM			Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR	bilirubin transport|response to metal ion|transmembrane transport	bilirubin transmembrane transporter activity|glutathione S-conjugate-exporting ATPase activity	fungal-type vacuole membrane|integral to membrane
YOR252W	YOR252W	TMA16	hom	Verified	0.982564692305824	0.162910864431372	no	891	0.150043553520337	529	NA	FT		NUCLEUS		Protein of unknown function that associates with ribosomes	biological_process	molecular_function	ribosome|nucleus
YLR375W	YLR375W	STP3	hom	Verified	0.979833446517362	0.163584169662677	no	892	0.17991249749475	603	NA	FT		NUCLEUS		Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids	biological_process	sequence-specific DNA binding	nucleus
YIL037C	YIL037C	PRM2	hom	Verified	0.977041390638792	0.164274330756326	no	893	0.170027346434222	621	NA					Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion	karyogamy involved in conjugation with cellular fusion	molecular_function	integral to membrane
YDR283C	YDR283C	GCN2	hom	Verified	0.976427182911666	0.164426408174506	no	894	0.229028723868906	847	NA	FF|FT	KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION		RIBOSOME	Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control	cellular amino acid biosynthetic process|protein phosphorylation|regulation of translational initiation|DNA damage checkpoint	protein homodimerization activity|protein kinase activity|eukaryotic translation initiation factor 2alpha kinase activity	cytosolic ribosome
YMR145C	YMR145C	NDE1	hom	Verified	0.975407119281351	0.16467917681574	no	895	0.161926924000359	526	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain	glucose catabolic process to ethanol|NADH oxidation|chronological cell aging	NADH dehydrogenase activity	mitochondrion
YOR190W	YOR190W	SPR1	hom	Verified	0.973882589932124	0.165057419565106	no	896	0.166752809104543	575	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance	ascospore formation	glucan exo-1,3-beta-glucosidase activity	fungal-type cell wall|ascospore wall
YAL029C	YAL029C	MYO4	hom	Verified	0.973090017194979	0.165254282545793	no	897	0.161409548518303	545	NA	FT	RNA LOCALIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH|CYTOSKELETON		Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication	mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization	microfilament motor activity|actin filament binding	mitochondrion|filamentous actin|myosin V complex|cellular bud|cellular bud tip
YMR172W	YMR172W	HOT1	hom	Verified	0.972890528770129	0.165303856354544	no	898	0.140173643474045	503	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p	cellular hyperosmotic salinity response|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YPR115W	YPR115W	RGC1	hom	Verified	0.972850879884371	0.165313710434803	no	899	0.172333895039956	595	NA	FT	CELL CYCLE			Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication	positive regulation of glycerol transport	molecular_function	cytoplasm
YPL183C	YPL183C	RTT10	hom	Verified	0.971889831782786	0.165552679443223	no	900	0.171693010129051	595	NA	FT	VESICLE-MEDIATED TRANSPORT			WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6	endocytic recycling	molecular_function	endosome|cytoplasm
YBR224W_d	YBR224W	YBR224W	hom	Dubious	0.971608432409526	0.165622692951317	no	901	0.149513616126364	536	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1	Unknown	Unknown	Unknown
YGR226C_d	YGR226C	YGR226C	hom	Dubious	0.970340255016797	0.165938459098711	no	902	0.170837625403037	566	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W	Unknown	Unknown	Unknown
YER071C_p	YER071C	TDA2	hom	Uncharacterized	0.969251392417158	0.166209887513186	no	903	0.152071208670322	441	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	mating projection tip|cytoplasm
YJR050W	YJR050W	ISY1	hom	Verified	0.968114490916645	0.166493596778946	no	904	0.190616319740308	625	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles	generation of catalytic spliceosome for second transesterification step|mRNA 3'-splice site recognition	first spliceosomal transesterification activity|second spliceosomal transesterification activity	post-spliceosomal complex|Prp19 complex|post-mRNA release spliceosomal complex|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YNL176C_p	YNL176C	TDA7	hom	Uncharacterized	0.966059334749731	0.167007245713086	no	905	0.166632257153717	531	NA					Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	fungal-type vacuole
YDL091C	YDL091C	UBX3	hom	Verified	0.965572338803022	0.167129111112347	no	906	0.14387147520391	472	NA					Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10	biological_process	molecular_function	cytoplasm
YLR319C	YLR319C	BUD6	hom	Verified	0.963907592228107	0.167546128551667	no	907	0.180628957983785	543	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate	bipolar cellular bud site selection|positive regulation of formin-nucleated actin cable assembly|cellular bud site selection|Rho protein signal transduction|extrachromosomal circular DNA localization involved in cell aging|establishment of cell polarity|response to osmotic stress|cytokinesis	cytoskeletal regulatory protein binding	polarisome|actin cap|spindle pole body|mating projection tip
YGR262C	YGR262C	BUD32	hom	Verified	0.963030705684899	0.167766057092414	no	908	0.201310451068134	597	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|LIPID METABOLISM|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	NUCLEUS|CHROMOSOME		Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription	threonylcarbamoyladenosine metabolic process|protein phosphorylation|telomere maintenance|cellular bud site selection|positive regulation of transcription from RNA polymerase II promoter	protein serine/threonine kinase activity	EKC/KEOPS complex|nucleus|cytoplasm
YKR014C	YKR014C	YPT52	hom	Verified	0.961668888415676	0.16810797757716	no	909	0.176059486207094	630	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress	endocytosis|protein targeting to vacuole	GTPase activity	late endosome
YIL074C	YIL074C	SER33	hom	Verified	0.960882114293033	0.168305722388276	no	910	0.165985918396293	606	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication	serine family amino acid biosynthetic process	phosphoglycerate dehydrogenase activity	cytoplasm
YDL036C	YDL036C	PUS9	hom	Verified	0.960379017052319	0.168432247322475	no	911	0.148156869629461	462	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|nucleus|cytoplasm
YER140W	YER140W	EMP65	hom	Verified	0.959120829660873	0.168748939068221	no	912	0.160351934736703	561	NA	FT		MITOCHONDRION		ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	protein folding in endoplasmic reticulum	molecular_function	mitochondrion|integral to membrane
YER019W	YER019W	ISC1	hom	Verified	0.959096156531543	0.168755153235225	no	913	0.178724544706717	659	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance	response to salt stress|ceramide biosynthetic process|sphingolipid catabolic process	inositol phosphosphingolipid phospholipase activity	mitochondrion|endoplasmic reticulum|integral to mitochondrial outer membrane
YOL052C	YOL052C	SPE2	hom	Verified	0.958970389642714	0.168786831131588	no	914	0.1836862461721	566	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically	spermidine biosynthetic process|spermine biosynthetic process|pantothenate biosynthetic process	adenosylmethionine decarboxylase activity	nucleus|cytoplasm
YDR071C	YDR071C	PAA1	hom	Verified	0.958819926861817	0.168824734396548	no	915	0.179817906490948	626	NA	FT	CHROMATIN ORGANIZATION			Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication	chromatin organization	diamine N-acetyltransferase activity|aralkylamine N-acetyltransferase activity	cytoplasm
YOR124C	YOR124C	UBP2	hom	Verified	0.957127692640126	0.169251403810158	no	916	0.161647291475498	576	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity	protein deubiquitination|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ubiquitin-specific protease activity	cytoplasm
YLR037C	YLR037C	PAU23	hom	Verified	0.955305932602311	0.169711504117477	no	917	0.170097741594197	583	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth	biological_process	molecular_function	fungal-type cell wall
YIL111W	YIL111W	COX5B	hom	Verified	0.95519084625841	0.16974059702414	no	918	0.157302779272575	530	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity|nitrite reductase (NO-forming) activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YKL161C	YKL161C	KDX1	hom	Verified	0.953916558112668	0.17006294062506	no	919	0.193841328581791	658	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p	biological_process	protein kinase activity	cellular_component
YDR430C	YDR430C	CYM1	hom	Verified	0.950998920088609	0.170802462034925	no	920	0.138535875198469	423	NA	FT	PROTEOLYSIS	MITOCHONDRION		Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology	proteolysis|proteolysis involved in cellular protein catabolic process	metalloendopeptidase activity	mitochondrion|mitochondrial intermembrane space
YML037C_p	YML037C	YML037C	hom	Uncharacterized	0.950639269077119	0.170893763527884	no	921	0.201160642949119	689	NA					Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene	biological_process	molecular_function	clathrin-coated vesicle
YFR039C_p	YFR039C	YFR039C	hom	Uncharacterized	0.95000202832972	0.171055610993443	no	922	0.145840922821483	493	NA					Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces	biological_process	molecular_function	cellular_component
YLR211C_p	YLR211C	YLR211C	hom	Uncharacterized	0.949998634285678	0.171056473280799	no	923	0.154612599164837	536	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron	biological_process	molecular_function	cytoplasm
YOR245C	YOR245C	DGA1	hom	Verified	0.949339725270752	0.171223927693144	no	924	0.15516465087461	515	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles	lipid storage|triglyceride biosynthetic process	diacylglycerol O-acyltransferase activity	integral to membrane|lipid particle
YMR230W	YMR230W	RPS10B	hom	Verified	0.948543490789527	0.171426421660104	no	925	0.183249150591854	632	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YNR014W_p	YNR014W	YNR014W	hom	Uncharacterized	0.947811230132623	0.171612781206017	no	926	0.188264881608004	621	NA					Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YDL167C	YDL167C	NRP1	hom	Verified	0.94718384122609	0.171772553923404	no	927	0.182785708104501	583	NA					Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	cytoplasmic stress granule|cytoplasm
YJL107C_p	YJL107C	YJL107C	hom	Uncharacterized	0.946881256033935	0.171849645113423	no	928	0.153998198323364	553	NA					Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi	biological_process	molecular_function	cellular_component
YOR050C_d	YOR050C	YOR050C	hom	Dubious	0.944654491973741	0.172417648695832	no	929	0.146703331484902	508	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable	Unknown	Unknown	Unknown
YOR279C	YOR279C	RFM1	hom	Verified	0.944370650885269	0.172490136911168	no	930	0.214047990233043	727	NA	FT	GENE SILENCING	NUCLEUS		DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance	chromatin silencing|chromatin silencing at silent mating-type cassette	unfolded protein binding	histone deacetylase complex|nucleus
YER130C_p	YER130C	YER130C	hom	Uncharacterized	0.943522385371596	0.172706885399527	no	931	0.229919849435209	787	NA	FT		NUCLEUS		Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress	biological_process	sequence-specific DNA binding	cellular_component
YGL125W	YGL125W	MET13	hom	Verified	0.941589333638443	0.173201466388548	no	932	0.18374142019559	568	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway	methionine biosynthetic process	methylenetetrahydrofolate reductase (NADPH) activity	mitochondrion
YGR187C	YGR187C	HGH1	hom	Verified	0.941243717427707	0.17328998898715	no	933	0.172325320927385	600	NA					Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	cytoplasm
YKL034W	YKL034W	TUL1	hom	Verified	0.940927292466384	0.173371060093597	no	934	0.170805344673637	624	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein ubiquitination	ubiquitin-protein ligase activity	integral to membrane|Golgi apparatus
YEL006W	YEL006W	YEA6	hom	Verified	0.939595816411098	0.173712461518715	no	935	0.177515974131911	609	NA	FT		MITOCHONDRION		Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog	transport|NAD transmembrane transport	transporter activity|NAD transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YGL224C	YGL224C	SDT1	hom	Verified	0.938602937327048	0.173967322068103	no	936	0.169387754135418	595	NA					Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives	pyrimidine nucleobase metabolic process	nucleotidase activity	cellular_component
YDR074W	YDR074W	TPS2	hom	Verified	0.938321522991094	0.174039601085857	no	937	0.259748329852885	885	NA	FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress	trehalose biosynthetic process|response to stress	trehalose-phosphatase activity	mitochondrion|alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YBL019W	YBL019W	APN2	hom	Verified	0.937534669487058	0.174241799404881	no	938	0.143565800941342	439	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII	base-excision repair	DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity	nucleus
YDR357C_p	YDR357C	CNL1	hom	Uncharacterized	0.934962713705996	0.174903757675937	no	939	0.159465184572819	532	NA					Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	BLOC-1 complex|cytoplasm
YEL030W	YEL030W	ECM10	hom	Verified	0.934389460977028	0.175051516067917	no	940	0.156828428697774	551	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog, SSC1, that arose from the whole genome duplication	protein refolding|protein targeting to mitochondrion	molecular_function	mitochondrial nucleoid|mitochondrion
YNR032W	YNR032W	PPG1	hom	Verified	0.931836562791248	0.175710497937051	no	941	0.171583768961805	537	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases	glycogen metabolic process|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YHR041C	YHR041C	SRB2	hom	Verified	0.93137888517809	0.175828804592065	no	942	0.224724891815377	757	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding	core mediator complex
YJL126W	YJL126W	NIT2	hom	Verified	0.92976290282865	0.176246928857667	no	943	0.177578946494933	628	NA					Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member	biological_process	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	cellular_component
YKL131W_d	YKL131W	YKL131W	hom	Dubious	0.929647415507423	0.17627683447628	no	944	0.135442413379099	458	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR085C	YKR085C	MRPL20	hom	Verified	0.929595043920895	0.176290397236989	no	945	0.186910065606934	652	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YPL001W	YPL001W	HAT1	hom	Verified	0.929579227328057	0.176294493417324	no	946	0.193577674782747	656	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair	histone acetylation|chromatin silencing at telomere	histone acetyltransferase activity|histone binding	histone acetyltransferase complex|nucleus|cytoplasm
YBL039W-B_p	YBL039W-B	YBL039W-B	hom	Uncharacterized	0.929215648111658	0.17638866974651	no	947	0.159768463835584	566	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL297C	YNL297C	MON2	hom	Verified	0.927846321498298	0.176743646014336	no	948	0.211515607957741	671	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins	transport|endocytosis|protein targeting to vacuole|Golgi to endosome transport	guanyl-nucleotide exchange factor activity	cytosol|endosome|trans-Golgi network|extrinsic to membrane
YLR152C_p	YLR152C	YLR152C	hom	Uncharacterized	0.927606683670116	0.176805814733692	no	949	0.171260158386056	595	NA					Putative protein of unknown function; YLR152C is not an essential gene	biological_process	molecular_function	integral to membrane
YGL026C	YGL026C	TRP5	hom	Verified	0.927107243200489	0.176935427904788	no	950	0.260915873156198	926	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis	tryptophan biosynthetic process	tryptophan synthase activity	nucleus|cytoplasm
YLR331C_d	YLR331C	JIP3	hom	Dubious	0.926621590509462	0.177061520482728	no	951	0.174694818277574	629	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2	Unknown	Unknown	Unknown
YLR093C	YLR093C	NYV1	hom	Verified	0.925395574191108	0.177380090070543	no	952	0.168621868724777	561	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane	vesicle-mediated transport|vacuole fusion, non-autophagic|vesicle fusion	SNAP receptor activity	SNARE complex|fungal-type vacuole membrane
YBL082C	YBL082C	ALG3	hom	Verified	0.924722782553698	0.177555062759979	no	953	0.158310982786393	528	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins	oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation	alpha-1,3-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YFL047W	YFL047W	RGD2	hom	Verified	0.923869338570394	0.17777717431748	no	954	0.181812996932852	622	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress	small GTPase mediated signal transduction	Rho GTPase activator activity	cellular bud neck|cytoplasm
YCR079W	YCR079W	PTC6	hom	Verified	0.923571439925193	0.177854744654513	no	955	0.193995150579114	708	NA	FT	RESPONSE TO NUTRIENT LEVELS	MITOCHONDRION		Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase	mitochondrion degradation|positive regulation of catalytic activity|macroautophagy|protein dephosphorylation	protein serine/threonine phosphatase activity	mitochondrion|mitochondrial matrix|mitochondrial intermembrane space
YFR031C-A	YFR031C-A	RPL2A	hom	Verified	0.923302853479167	0.177924700635811	no	956	0.174014041670125	601	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR256W	YGR256W	GND2	hom	Verified	0.922592210385734	0.178109878300851	no	957	0.162563381406743	600	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	phosphogluconate dehydrogenase (decarboxylating) activity	cytosol|plasma membrane
YIL001W_p	YIL001W	YIL001W	hom	Uncharacterized	0.922529111289534	0.178126326382058	no	958	0.194525714356184	640	NA					Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm	biological_process	molecular_function	cytoplasm
YGL147C	YGL147C	RPL9A	hom	Verified	0.921958468644445	0.178275119643291	no	959	0.1803653887948	644	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOL012C	YOL012C	HTZ1	hom	Verified	0.92143810483959	0.178410871113752	no	960	0.202035588987962	749	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin	nuclear-transcribed mRNA catabolic process, non-stop decay|regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	chromatin binding	nuclear chromatin|chromatin assembly complex
YDR034W-B_p	YDR034W-B	YDR034W-B	hom	Uncharacterized	0.920892664525937	0.178553234381627	no	961	0.184338696621177	603	NA					Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YPL029W	YPL029W	SUV3	hom	Verified	0.920336071754705	0.178698582243842	no	962	0.239760380146675	812	NA	FF|FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION|CHROMOSOME		ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron	mitochondrial DNA replication|mitochondrial RNA catabolic process|Group I intron splicing	exoribonuclease II activity|ATP-dependent RNA helicase activity	mitochondrion|mitochondrial chromosome|mitochondrial degradosome
YMR026C	YMR026C	PEX12	hom	Verified	0.919821352781772	0.17883306152111	no	963	0.200893470615806	645	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder	protein import into peroxisome matrix	ubiquitin-protein ligase activity|protein binding	integral to peroxisomal membrane
YBR040W	YBR040W	FIG1	hom	Verified	0.919190450154577	0.178997982665749	no	964	0.165806273461195	574	NA	FT		SITE OF POLARIZED GROWTH		Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating	cell morphogenesis involved in conjugation with cellular fusion|cytogamy	molecular_function	fungal-type cell wall|integral to membrane|mating projection tip
YGR011W_d	YGR011W	YGR011W	hom	Dubious	0.915994417327358	0.179834911498664	no	965	0.161697770879548	531	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR137W	YLR137W	RKM5	hom	Verified	0.915315470674721	0.180013019841435	no	966	0.15623293516001	548	NA					Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species	protein methylation	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YLL002W	YLL002W	RTT109	hom	Verified	0.914321419675972	0.180273989350813	no	967	0.18718527037171	629	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS		Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p	negative regulation of transposition, RNA-mediated|histone acetylation|double-strand break repair via nonhomologous end joining|response to DNA damage stimulus|regulation of transcription from RNA polymerase II promoter in response to stress	H3 histone acetyltransferase activity	nucleus
YOR152C_p	YOR152C	YOR152C	hom	Uncharacterized	0.913145555934068	0.18058299676475	no	968	0.143432023261346	485	NA					Putative protein of unknown function; YOR152C is not an essential gene	biological_process	molecular_function	membrane
YPR027C_p	YPR027C	YPR027C	hom	Uncharacterized	0.913009787721732	0.18061869692437	no	969	0.201324554010139	719	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR209C	YLR209C	PNP1	hom	Verified	0.91291390051368	0.180643913067427	no	970	0.191581629856219	635	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway	guanosine catabolic process|inosine catabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinate nucleotide salvage	nicotinamide riboside hydrolase activity|inosine nucleosidase activity|purine-nucleoside phosphorylase activity	intracellular
YCR010C	YCR010C	ADY2	hom	Verified	0.912362590994538	0.180788937694958	no	971	0.198828961991882	663	NA	FT	CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication	nitrogen utilization|ammonium transport|acetate transport|transmembrane transport	acetate transmembrane transporter activity|ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YHR132W-A	YHR132W-A	IGO2	hom	Verified	0.910697255966534	0.181227455162924	no	972	0.188608684846811	607	NA	FT		NUCLEUS		Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p	mRNA stabilization	molecular_function	nucleus|cytoplasm
YKL048C	YKL048C	ELM1	hom	Verified	0.910374406787928	0.181312545117908	no	973	0.185469175311657	681	NA	FT	CELL CYCLE|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring	positive regulation of protein autophosphorylation|protein autophosphorylation|cell morphogenesis|budding cell bud growth|protein phosphorylation|response to drug|septin checkpoint|pseudohyphal growth|glucose metabolic process|axial cellular bud site selection|response to osmotic stress|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	cellular bud neck contractile ring
YCR004C	YCR004C	YCP4	hom	Verified	0.91031855694359	0.181327267410481	no	974	0.171475186219875	557	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	electron carrier activity	mitochondrion|membrane raft|plasma membrane|cytoplasm
YLR250W	YLR250W	SSP120	hom	Verified	0.908042447589141	0.181927897754658	no	975	0.181099399589425	592	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YPL189C-A	YPL189C-A	COA2	hom	Verified	0.906903481887111	0.182228919864607	no	976	0.176409885306295	580	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrial matrix
YHL009C	YHL009C	YAP3	hom	Verified	0.906250814567603	0.182401556314124	no	977	0.192370602345453	666	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YML018C	YML018C	YML018C	hom	Verified	0.90542090009072	0.182621223765261	no	978	0.183454860855486	647	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YGR052W_p	YGR052W	FMP48	hom	Uncharacterized	0.903932408181704	0.183015621654365	no	979	0.219677325343756	748	NA	FT	PROTEIN PHOSPHORYLATION	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation	protein phosphorylation	protein kinase activity	mitochondrion
YER072W	YER072W	VTC1	hom	Verified	0.90344482724894	0.183144928884104	no	980	0.179015016353981	577	NA	FT	MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress	polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic	mRNA binding	integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex|intrinsic to vacuolar membrane
YOR094W	YOR094W	ARF3	hom	Verified	0.90334699189536	0.183170881836673	no	981	0.152328559381323	508	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	GOLGI APPARATUS|SITE OF POLARIZED GROWTH		Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity	intracellular protein transport|positive regulation of phosphatidylinositol biosynthetic process|endocytosis|actin filament bundle assembly|actin cortical patch localization|cellular bud site selection	mRNA binding|GTPase activity	cellular bud neck|cellular bud tip
YDR252W	YDR252W	BTT1	hom	Verified	0.903232320361932	0.183201303871502	no	982	0.177300374790341	575	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3	'de novo' cotranslational protein folding	unfolded protein binding	nascent polypeptide-associated complex|CCR4-NOT complex
YLR203C	YLR203C	MSS51	hom	Verified	0.903177769549053	0.183215777154585	no	983	0.161925726654347	534	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	extrinsic to mitochondrial inner membrane|mitochondrion
YGL110C	YGL110C	CUE3	hom	Verified	0.903161010155321	0.183220223857548	no	984	0.156568060388019	544	NA					Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination	biological_process	ubiquitin binding	cytoplasm
YOL024W_p	YOL024W	YOL024W	hom	Uncharacterized	0.902425398675397	0.183415467021525	no	985	0.171722847477949	596	NA					Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLR288C	YLR288C	MEC3	hom	Verified	0.901021259153159	0.183788508242282	no	986	0.160778901253777	509	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1	telomere maintenance via recombination|DNA damage checkpoint|DNA metabolic process|chromatin silencing at telomere	DNA binding	nucleus|checkpoint clamp complex
YGL262W_p	YGL262W	YGL262W	hom	Uncharacterized	0.89975538325062	0.184125221420351	no	987	0.162208022724454	560	NA					Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene	biological_process	molecular_function	cellular_component
YMR013W-A_d	YMR013W-A	YMR013W-A	hom	Dubious	0.896856035452228	0.184897871230548	no	988	0.172445842460216	568	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73	Unknown	Unknown	Unknown
YPL022W	YPL022W	RAD1	hom	Verified	0.892220224957945	0.186137451837666	no	989	0.185589730082559	630	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein	mitotic recombination|meiotic mismatch repair|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair via single-strand annealing, removal of nonhomologous ends|removal of nonhomologous ends	single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity	nucleotide-excision repair factor 1 complex|nucleus
YGR161C_p	YGR161C	RTS3	hom	Uncharacterized	0.891819646816609	0.186244804630415	no	990	0.183904752919152	617	NA	FT		NUCLEUS		Putative component of the protein phosphatase type 2A complex	biological_process	molecular_function	nucleus|cytoplasm
YLR017W	YLR017W	MEU1	hom	Verified	0.891762330966126	0.18626016810775	no	991	0.169177349141209	585	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression	L-methionine salvage from methylthioadenosine|glutamate biosynthetic process	S-methyl-5-thioadenosine phosphorylase activity|mRNA binding	cytoplasm
YNL042W	YNL042W	BOP3	hom	Verified	0.891514691310903	0.186326556786115	no	992	0.159876538516434	510	NA	FT		NUCLEUS		Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury	cellular response to methylmercury	molecular_function	nucleus|cytoplasm
YLR040C_p	YLR040C	YLR040C	hom	Uncharacterized	0.890074788957764	0.186712864560369	no	993	0.193107329819654	652	NA					Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential	biological_process	molecular_function	fungal-type cell wall
YPR109W_p	YPR109W	YPR109W	hom	Uncharacterized	0.89001756181377	0.186728228123888	no	994	0.20684726813893	670	NA	FT	CELL CYCLE			Predicted membrane protein; dipoid deletion strain has high budding index	biological_process	molecular_function	cellular_component
YDR384C	YDR384C	ATO3	hom	Verified	0.888847409403775	0.18704254626647	no	995	0.182956860514033	616	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters	ammonium transport|nitrogen utilization|transmembrane transport	ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YOR344C	YOR344C	TYE7	hom	Verified	0.887976991977921	0.187276563845685	no	996	0.179324342710579	603	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|CHROMOSOME		Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression	positive regulation of glycolysis|transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nuclear chromatin|nucleus
YGR189C	YGR189C	CRH1	hom	Verified	0.887756904900987	0.18733576439848	no	997	0.167588314661561	561	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress	fungal-type cell wall organization|cell wall chitin metabolic process	transferase activity, transferring glycosyl groups	incipient cellular bud site|fungal-type cell wall
YKR018C	YKR018C	YKR018C	hom	Verified	0.887106023069373	0.187510910811311	no	998	0.182213002262237	651	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YGR067C_p	YGR067C	YGR067C	hom	Uncharacterized	0.885001211626398	0.18807798893983	no	999	0.169352299596107	573	NA	FT		NUCLEUS		Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p	biological_process	sequence-specific DNA binding	cellular_component
YPR146C_d	YPR146C	YPR146C	hom	Dubious	0.884458936193463	0.188224260056548	no	1000	0.171141423601194	622	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR298C-A	YOR298C-A	MBF1	hom	Verified	0.881264809263407	0.189087254194153	no	1001	0.153567273194632	512	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress	positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity	mitochondrion|nucleus
YLR233C	YLR233C	EST1	hom	Verified	0.880245164093052	0.18936325582025	no	1002	0.151252510315066	490	NA	FT		NUCLEUS|CHROMOSOME		TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA	telomere maintenance via telomerase|telomere maintenance|G-quadruplex DNA formation	single-stranded DNA binding|RNA binding|telomeric DNA binding	nucleolus|nucleus|telomerase holoenzyme complex
YJR048W	YJR048W	CYC1	hom	Verified	0.877701436338963	0.190052882410857	no	1003	0.157337913037055	538	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c	electron carrier activity	mitochondrion|mitochondrial intermembrane space
YDR102C_d	YDR102C	YDR102C	hom	Dubious	0.875348185576789	0.190692241656098	no	1004	0.172181011424539	551	NA					Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index	Unknown	Unknown	Unknown
YER010C	YER010C	YER010C	hom	Verified	0.874669422635374	0.190876901083639	no	1005	0.194495525977747	692	NA					Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction	biological_process	molecular_function	cellular_component
YKL171W	YKL171W	NNK1	hom	Verified	0.874520269191336	0.190917493408103	no	1006	0.156588674191369	513	NA	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION			Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm	proteolysis|protein phosphorylation	protein kinase activity	cytoplasm
YGL063W	YGL063W	PUS2	hom	Verified	0.874066054224764	0.191041141279503	no	1007	0.186797014432715	644	NA	FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion
YLR189C	YLR189C	ATG26	hom	Verified	0.873720682204446	0.191135192432205	no	1008	0.162038061943972	528	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM			UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy	sterol metabolic process|ascospore-type prospore membrane assembly	sterol 3-beta-glucosyltransferase activity	cytoplasm
YGL215W	YGL215W	CLG1	hom	Verified	0.872747671522759	0.191400313757848	no	1009	0.208661536153441	677	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS			Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2	positive regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YKL156W	YKL156W	RPS27A	hom	Verified	0.871682885018971	0.191690699824453	no	1010	0.204005507027697	684	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasm
YPL145C	YPL145C	KES1	hom	Verified	0.871380145984053	0.191773311336193	no	1011	0.205506961239466	698	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication	post-Golgi vesicle-mediated transport|positive regulation of phosphatase activity|maintenance of cell polarity|endocytosis|exocytosis|sterol transport	phosphatidic acid binding|lipid binding|phosphatidylinositol-4,5-bisphosphate binding|oxysterol binding|sterol transporter activity|phosphatidylinositol-4-phosphate binding	Golgi membrane|extrinsic to membrane|cytoplasm
YGL134W	YGL134W	PCL10	hom	Verified	0.86973818223665	0.192221750497007	no	1012	0.159969677926621	569	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY			Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate	negative regulation of glycogen biosynthetic process|regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YOR097C_p	YOR097C	YOR097C	hom	Uncharacterized	0.867806014425996	0.192750268473413	no	1013	0.214211654327885	761	NA					Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene	biological_process	molecular_function	cellular_component
YPR167C	YPR167C	MET16	hom	Verified	0.867380534004885	0.192866771977822	no	1014	0.188495951222291	638	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process	phosphoadenylyl-sulfate reductase (thioredoxin) activity	cytoplasm
YOR238W_p	YOR238W	YOR238W	hom	Uncharacterized	0.867219718662237	0.192910817050059	no	1015	0.164572907213014	558	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YJR063W	YJR063W	RPA12	hom	Verified	0.866977234453	0.192977241696826	no	1016	0.225339850526477	797	NA	FF|FT		NUCLEUS		RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex	termination of RNA polymerase I transcription|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	molecular_function	DNA-directed RNA polymerase I complex
YFR014C	YFR014C	CMK1	hom	Verified	0.866308701169631	0.193160447958074	no	1017	0.164985726873376	508	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication	signal transduction|protein phosphorylation	protein kinase activity|calmodulin-dependent protein kinase activity	cytoplasm
YJR118C	YJR118C	ILM1	hom	Verified	0.865008647968656	0.19351702112127	no	1018	0.231429134142702	805	NA	FF|FT	MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth	mitochondrial genome maintenance	molecular_function	integral to membrane|endoplasmic reticulum
YDR059C	YDR059C	UBC5	hom	Verified	0.862527306805822	0.194198706566011	no	1019	0.193032198136505	628	NA					Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication	protein polyubiquitination|response to stress	ubiquitin-protein ligase activity	proteasome complex
YCR061W_p	YCR061W	YCR061W	hom	Uncharacterized	0.861737776681457	0.194415916253679	no	1020	0.199580659811686	691	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation	regulation of cell size	molecular_function	integral to membrane|cytoplasm
YPL027W	YPL027W	SMA1	hom	Verified	0.859927403258535	0.194914530863048	no	1021	0.165735912846727	547	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p	ascospore-type prospore membrane assembly	molecular_function	prospore membrane
YOR300W_d	YOR300W	YOR300W	hom	Dubious	0.857339980648894	0.19562850947942	no	1022	0.173902044148602	574	NA					Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7	Unknown	Unknown	Unknown
YMR074C	YMR074C	YMR074C	hom	Verified	0.854861596253455	0.196313886643933	no	1023	0.172922489205917	581	NA	FT		NUCLEUS		Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress	apoptotic process	molecular_function	nucleus|cytoplasm
YLR202C_d	YLR202C	YLR202C	hom	Dubious	0.854553660353993	0.196399145376308	no	1024	0.193066706333773	681	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron	Unknown	Unknown	Unknown
YPR117W_p	YPR117W	YPR117W	hom	Uncharacterized	0.853865965065961	0.196589629738683	no	1025	0.193789137565816	634	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL231C	YNL231C	PDR16	hom	Verified	0.853724916896234	0.196628712426432	no	1026	0.216772790472495	752	NA	FF|FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress	response to drug|sterol biosynthetic process|phospholipid biosynthetic process|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cell periphery|lipid particle|plasma membrane|cytoplasm
YBR050C	YBR050C	REG2	hom	Verified	0.853576059657294	0.196669964014357	no	1027	0.160538588610085	513	NA	FT	TRANSCRIPTION FROM RNA POL II			Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease	negative regulation of transcription from RNA polymerase II promoter	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex
YBR134W_d	YBR134W	YBR134W	hom	Dubious	0.850394235629468	0.197552969938992	no	1028	0.188092649769868	692	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR483W	YDR483W	KRE2	hom	Verified	0.849256604896687	0.197869261010975	no	1029	0.244742623575091	818	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication	N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YDL135C	YDL135C	RDI1	hom	Verified	0.847548725918154	0.198344669973612	no	1030	0.163562141982417	519	NA	FT	MEMBRANE ORGANIZATION|SIGNALING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress	regulation of vacuole fusion, non-autophagic|actin filament organization|small GTPase mediated signal transduction	Rho GDP-dissociation inhibitor activity	cytosol|plasma membrane|cellular bud neck|cellular bud tip
YDR297W	YDR297W	SUR2	hom	Verified	0.846016397685552	0.198771798370802	no	1031	0.214233184402938	714	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis	sphingolipid metabolic process	sphingosine hydroxylase activity	integral to membrane|endoplasmic reticulum membrane
YOL118C_d	YOL118C	YOL118C	hom	Dubious	0.845412731478766	0.19894021928834	no	1032	0.216229032367632	721	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL090W	YKL090W	CUE2	hom	Verified	0.84517675817012	0.199006078451004	no	1033	0.189600658693674	635	NA					Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination	biological_process	ubiquitin binding	cellular_component
YLR169W_d	YLR169W	YLR169W	hom	Dubious	0.843683127866451	0.199423249095216	no	1034	0.176653280021437	606	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL179C	YKL179C	COY1	hom	Verified	0.843571420241169	0.199454470157721	no	1035	0.111976645089142	366	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function	Golgi vesicle transport	molecular_function	Golgi membrane
YOR010C	YOR010C	TIR2	hom	Verified	0.842947552629939	0.199628888445265	no	1036	0.170560018533865	538	NA					Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis	response to stress	molecular_function	fungal-type cell wall
YGR010W	YGR010W	NMA2	hom	Verified	0.841669780608217	0.199986408956427	no	1037	0.206342160458614	638	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication	NAD biosynthetic process	nicotinamide-nucleotide adenylyltransferase activity	nucleus
YPR079W	YPR079W	MRL1	hom	Verified	0.841661977308144	0.199988593501214	no	1038	0.18552147633659	617	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress	vacuolar transport	signal sequence binding	late endosome|cytoplasm
YPL147W	YPL147W	PXA1	hom	Verified	0.840858671658072	0.200213556799212	no	1039	0.190240578679796	637	NA	FT	NUCLEOTIDE METABOLISM			Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder	fatty acid transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|integral to peroxisomal membrane
YER053C-A	YER053C-A	YER053C-A	hom	Verified	0.839567227621958	0.200575540369596	no	1040	0.176034524149921	590	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	endoplasmic reticulum
YPL046C	YPL046C	ELC1	hom	Verified	0.838874935461142	0.200769747158444	no	1041	0.173121059980074	603	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair	global genome nucleotide-excision repair|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	elongin complex|Cul3-RING ubiquitin ligase complex
YOR284W	YOR284W	HUA2	hom	Verified	0.836888345666009	0.201327665925439	no	1042	0.196599361551564	649	NA					Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly	biological_process	molecular_function	cytoplasm
YKL119C	YKL119C	VPH2	hom	Verified	0.836742304941067	0.201368717001253	no	1043	0.2088078905995	694	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)	vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification	molecular_function	endoplasmic reticulum membrane
YDR359C	YDR359C	EAF1	hom	Verified	0.836179152809431	0.201527062285985	no	1044	0.231160581382183	788	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1	DNA repair|cellular protein complex assembly|chromatin modification	molecular_function	histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YJR055W	YJR055W	HIT1	hom	Verified	0.835995747160836	0.201578647790514	no	1045	0.158133506738787	561	NA	FT		NUCLEUS		Protein of unknown function, required for growth at high temperature	biological_process	molecular_function	nucleus|cytoplasm
YML075C	YML075C	HMG1	hom	Verified	0.835187242153883	0.201806145861118	no	1046	0.20085579599961	685	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress	ergosterol biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway	hydroxymethylglutaryl-CoA reductase (NADPH) activity	nuclear envelope|integral to membrane|endoplasmic reticulum membrane
YAL054C	YAL054C	ACS1	hom	Verified	0.834234210621667	0.202074508299093	no	1047	0.180824375346267	602	NA	FT	KETONE METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions	acetate fermentation|histone acetylation|acetyl-CoA biosynthetic process	acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity	cytosol|mitochondrion|integral to membrane
YDR438W	YDR438W	THI74	hom	Verified	0.830886692420957	0.203018821021916	no	1048	0.210033075971194	688	NA	FT		MITOCHONDRION		Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane
YLR345W_p	YLR345W	YLR345W	hom	Uncharacterized	0.830629882973712	0.20309137393702	no	1049	0.203208537802785	684	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YJL004C	YJL004C	SYS1	hom	Verified	0.830580747449314	0.20310525729918	no	1050	0.253222103884086	899	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation	vesicle organization|Golgi to plasma membrane protein transport|Golgi to endosome transport	molecular_function	trans-Golgi network|integral to membrane|integral to Golgi membrane
YPL004C	YPL004C	LSP1	hom	Verified	0.83009763564512	0.203241791888316	no	1051	0.18993999019038	655	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family	negative regulation of protein kinase activity|endocytosis|response to heat	lipid binding	mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YKL010C	YKL010C	UFD4	hom	Verified	0.82995750532436	0.20328140505024	no	1052	0.20363353385016	657	NA	FT	PROTEOLYSIS	MITOCHONDRION		Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress	protein monoubiquitination|protein polyubiquitination	ubiquitin-protein ligase activity	mitochondrion|cytoplasm
YFL056C	YFL056C	AAD6	hom	Verified	0.82992992386609	0.203289202540554	no	1053	0.197471536301126	674	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YBR072C-A_p	YBR072C-A	YBR072C-A	hom	Uncharacterized	0.829762486050251	0.203336542329135	no	1054	0.198121833717284	647	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YOR379C_d	YOR379C	YOR379C	hom	Dubious	0.827771451784086	0.203899972601256	no	1055	0.192801857671902	675	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W	Unknown	Unknown	Unknown
YPR066W	YPR066W	UBA3	hom	Verified	0.827350704818136	0.204019156112587	no	1056	0.214715303280374	730	NA					Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	protein neddylation	NEDD8 activating enzyme activity	cytoplasm
YBL071W-A	YBL071W-A	KTI11	hom	Verified	0.82476582736686	0.204752275546473	no	1057	0.256055230300328	866	NA	FT	RNA PROCESSING	NUCLEUS		Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs	peptidyl-diphthamide biosynthetic process from peptidyl-histidine|tRNA wobble uridine modification	electron carrier activity|iron ion binding|zinc ion binding	nucleus|cytoplasm
YDR165W	YDR165W	TRM82	hom	Verified	0.82352072093595	0.205105969382815	no	1058	0.228014293105837	737	NA	FT	RNA PROCESSING	NUCLEUS		Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p	tRNA methylation	tRNA (guanine-N7-)-methyltransferase activity	tRNA methyltransferase complex|nucleus
YKL033W-A_p	YKL033W-A	YKL033W-A	hom	Uncharacterized	0.823496606120601	0.205112823192142	no	1059	0.249706383656007	843	NA					Putative protein of unknown function; similar to uncharacterized proteins from other fungi	biological_process	molecular_function	cellular_component
YOL058W	YOL058W	ARG1	hom	Verified	0.822841159496275	0.205299163539975	no	1060	0.226750394524604	770	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate	argininosuccinate metabolic process|arginine biosynthetic process|citrulline metabolic process	argininosuccinate synthase activity	cytosol
YNL305C	YNL305C	BXI1	hom	Verified	0.822218290770097	0.205476335302432	no	1061	0.187292183701896	604	NA	FT	SIGNALING	ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p	endoplasmic reticulum unfolded protein response|apoptotic process|calcium-mediated signaling	molecular_function	mitochondrion|integral to membrane|endoplasmic reticulum|fungal-type vacuole
YLR280C_d	YLR280C	YLR280C	hom	Dubious	0.820251710919208	0.20603631422663	no	1062	0.17791052871947	579	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER063W	YER063W	THO1	hom	Verified	0.819931986363889	0.206127440485573	no	1063	0.169588881768223	560	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation	poly(A)+ mRNA export from nucleus|transcription, DNA-dependent|ribonucleoprotein complex assembly	chromatin binding|double-stranded DNA binding|RNA binding	nucleus
YBR137W	YBR137W	YBR137W	hom	Verified	0.816148144737152	0.207207705388922	no	1064	0.18061887203025	635	NA					Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene	biological_process	molecular_function	TRC complex|cytoplasm
YOR142W	YOR142W	LSC1	hom	Verified	0.816081957416261	0.20722663123482	no	1065	0.187179881574251	656	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated	tricarboxylic acid cycle|succinyl-CoA metabolic process	succinate-CoA ligase (ADP-forming) activity	mitochondrial nucleoid|mitochondrion
YJR083C	YJR083C	ACF4	hom	Verified	0.816036530573497	0.20723962134487	no	1066	0.19161195168992	613	NA					Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate	biological_process	molecular_function	cellular_component
YNR006W	YNR006W	VPS27	hom	Verified	0.815632482604283	0.207355182757535	no	1067	0.2496834799475	864	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)	protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding|phosphatidylinositol-3-phosphate binding	endosome|ESCRT-0 complex
YOR268C_p	YOR268C	YOR268C	hom	Uncharacterized	0.815235853734149	0.207468659287469	no	1068	0.160983841216639	533	NA					Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene	biological_process	molecular_function	cellular_component
YMR153W	YMR153W	NUP53	hom	Verified	0.815216893926955	0.207474084655701	no	1069	0.195405949254582	683	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication	positive regulation of transcription, DNA-dependent|NLS-bearing substrate import into nucleus|regulation of protein desumoylation|nuclear pore organization|protein import into nucleus|regulation of mitosis|mitotic cell cycle spindle assembly checkpoint	nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding	nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YMR241W	YMR241W	YHM2	hom	Verified	0.815176542275615	0.207485631601182	no	1070	0.213298686189041	725	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome	tricarboxylic acid transport|mitochondrial citrate transport|alpha-ketoglutarate transport|mitochondrial genome maintenance	tricarboxylate secondary active transmembrane transporter activity|DNA binding	mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YGR068C	YGR068C	ART5	hom	Verified	0.813919947435566	0.207845406248848	no	1071	0.211329005722978	699	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane	ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	cellular_component
YGR008C	YGR008C	STF2	hom	Verified	0.812808760175	0.208163856093873	no	1072	0.207599562211829	689	NA	FT		MITOCHONDRION		Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress	cellular response to desiccation	molecular_function	cytoplasm
YER173W	YER173W	RAD24	hom	Verified	0.812415920251198	0.208276507062704	no	1073	0.217195797169055	693	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein	reciprocal meiotic recombination|DNA damage checkpoint|nucleotide-excision repair	DNA clamp loader activity	Rad17 RFC-like complex|nucleus
YOR043W	YOR043W	WHI2	hom	Verified	0.810312483866114	0.208880301092661	no	1074	0.181983797618072	624	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION			Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression	response to salt stress|mitochondrion degradation|actin filament organization|endocytosis|response to heat|regulation of growth|response to stress	phosphatase activator activity	cellular_component
YNL230C	YNL230C	ELA1	hom	Verified	0.809274604499046	0.209178605211616	no	1075	0.219758741273166	785	NA	FT	PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	elongin complex|Cul3-RING ubiquitin ligase complex
YNL215W	YNL215W	IES2	hom	Verified	0.808781735532944	0.209320351891958	no	1076	0.225997801731501	761	NA	FT		NUCLEUS		Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YOL015W	YOL015W	IRC10	hom	Verified	0.80826318849989	0.209469544465378	no	1077	0.230422941970185	782	NA					Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YBR178W_d	YBR178W	YBR178W	hom	Dubious	0.807793223589043	0.20960481337318	no	1078	0.217453313035405	712	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C	Unknown	Unknown	Unknown
YLR402W_d	YLR402W	YLR402W	hom	Dubious	0.807430317136188	0.209709303038964	no	1079	0.22228110142865	724	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL273W	YNL273W	TOF1	hom	Verified	0.806793706135482	0.209892672926519	no	1080	0.200858609148917	669	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase	DNA repair|DNA replication checkpoint|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|DNA replication|mitotic sister chromatid cohesion	molecular_function	nuclear chromosome|replication fork protection complex|nuclear replication fork
YBL088C	YBL088C	TEL1	hom	Verified	0.806086737025005	0.210096419211348	no	1081	0.205549411598571	693	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)	double-strand break repair|histone phosphorylation|telomere maintenance|response to DNA damage stimulus|phosphorylation|DNA damage induced protein phosphorylation	protein kinase activity|telomeric DNA binding	mitochondrion|nucleus
YKR094C	YKR094C	RPL40B	hom	Verified	0.804466173864576	0.210563898638278	no	1082	0.203509824974047	725	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION	NUCLEUS|MITOCHONDRION	RIBOSOME	Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication	cytoplasmic translation|protein ubiquitination|ribosome biogenesis	structural constituent of ribosome|protein tag	mitochondrion|cytosolic large ribosomal subunit
YOR180C	YOR180C	DCI1	hom	Verified	0.804401782932834	0.210582485914372	no	1083	0.239713401322091	817	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed	fatty acid beta-oxidation	dodecenoyl-CoA delta-isomerase activity	peroxisomal matrix
YOR283W	YOR283W	YOR283W	hom	Verified	0.803985387580731	0.210702707066077	no	1084	0.204267152344278	697	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene	dephosphorylation	phosphatase activity	nucleus|cytoplasm
YLR315W	YLR315W	NKP2	hom	Verified	0.802871898144266	0.211024390087848	no	1085	0.255638472478593	849	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2	biological_process	molecular_function	spindle pole body|kinetochore
YBL027W	YBL027W	RPL19B	hom	Verified	0.80222303163131	0.211211977935835	no	1086	0.198816093055689	661	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YMR122C_d	YMR122C	YMR122C	hom	Dubious	0.801669115338847	0.211372192875807	no	1087	0.24244970624407	815	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL093W	YNL093W	YPT53	hom	Verified	0.801470775888093	0.211429577949992	no	1088	0.263527304386204	904	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication	endocytosis|protein targeting to vacuole	GTPase activity	late endosome
YOL059W	YOL059W	GPD2	hom	Verified	0.800768025014825	0.211632976583423	no	1089	0.24778803261398	838	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1	NADH oxidation|glycerol metabolic process	glycerol-3-phosphate dehydrogenase [NAD+] activity	cytosol|mitochondrion
YLL053C_p	YLL053C	YLL053C	hom	Uncharacterized	0.80066571652793	0.211662597487872	no	1090	0.192053139714039	644	NA					Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin	biological_process	molecular_function	integral to membrane
YGR176W_d	YGR176W	YGR176W	hom	Dubious	0.799552894937896	0.211984944305608	no	1091	0.191112080269961	655	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR277C_d	YOR277C	YOR277C	hom	Dubious	0.799251380253623	0.212072332333764	no	1092	0.232951493791886	795	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20	Unknown	Unknown	Unknown
YJR090C	YJR090C	GRR1	hom	Verified	0.798837302877164	0.212192378740442	no	1093	0.248299047526915	843	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	UBIQUITIN LIGASE COMPLEX	F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|cell cycle arrest in response to pheromone|G1/S transition of mitotic cell cycle|response to DNA damage stimulus|protein ubiquitination	ubiquitin-protein ligase activity|protein binding, bridging	cellular bud neck contractile ring|SCF ubiquitin ligase complex|nucleus|cytoplasm
YGL050W	YGL050W	TYW3	hom	Verified	0.798297493673458	0.212348936070361	no	1094	0.210457020351313	710	NA	FT	RNA PROCESSING			tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions	tRNA methylation|wybutosine biosynthetic process	tRNA methyltransferase activity	cellular_component
YFR016C	YFR016C	YFR016C	hom	Verified	0.797236092145482	0.212656964176273	no	1095	0.168248039862655	561	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene	biological_process	molecular_function	cellular bud|cytoplasm
YOL073C	YOL073C	YOL073C	hom	Verified	0.79659611108953	0.212842818358532	no	1096	0.210242979858424	715	NA					Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2	biological_process	molecular_function	integral to membrane
YHR071W	YHR071W	PCL5	hom	Verified	0.795856165300137	0.213057821008355	no	1097	0.173720928302243	625	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity	negative regulation of sequence-specific DNA binding transcription factor activity|regulation of protein stability|negative regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YOR058C	YOR058C	ASE1	hom	Verified	0.794862660755648	0.213346698238868	no	1098	0.179280505462592	636	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress	cytokinesis, completion of separation|mitotic anaphase B|microtubule bundle formation|spindle pole body separation|spindle midzone assembly|mitotic spindle stabilization|mitotic spindle elongation	microtubule binding	spindle midzone|nuclear microtubule|spindle
YIL069C	YIL069C	RPS24B	hom	Verified	0.79397600938488	0.213604698933345	no	1099	0.190700559907071	692	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YOL036W_p	YOL036W	YOL036W	hom	Uncharacterized	0.792855525414001	0.21393100087211	no	1100	0.213286387564064	728	NA					Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YGR258C	YGR258C	RAD2	hom	Verified	0.792230528159313	0.214113135566663	no	1101	0.179112883005317	603	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE	NUCLEUS		Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein	nucleotide-excision repair, DNA incision, 3'-to lesion|transcription from RNA polymerase II promoter	single-stranded DNA specific endodeoxyribonuclease activity	nucleotide-excision repair factor 3 complex
YDR139C	YDR139C	RUB1	hom	Verified	0.792037597794659	0.214169376936166	no	1102	0.185401084408115	616	NA					Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)	protein neddylation	protein tag	cytoplasm
YFR046C	YFR046C	CNN1	hom	Verified	0.791926159356633	0.214201866409248	no	1103	0.196267379042516	689	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T	chromosome segregation	molecular_function	nucleus|kinetochore
YDR379W	YDR379W	RGA2	hom	Verified	0.791686225686158	0.214271827934715	no	1104	0.194645358231191	628	NA	FT	SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p	budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|actin filament organization|pseudohyphal growth|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth	Rho GTPase activator activity	cellular bud neck split septin rings
YLR246W	YLR246W	ERF2	hom	Verified	0.790959487131493	0.214483816496144	no	1105	0.189586059210405	630	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole	protein targeting to membrane|protein palmitoylation	palmitoyltransferase activity	endoplasmic reticulum palmitoyltransferase complex|integral to endoplasmic reticulum membrane|integral to membrane
YBR199W	YBR199W	KTR4	hom	Verified	0.790823279706642	0.214523561565136	no	1106	0.16591232599147	575	NA	FT	CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family	protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YOR325W_d	YOR325W	YOR325W	hom	Dubious	0.790580497957391	0.214594415437178	no	1107	0.217448580411718	760	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1	Unknown	Unknown	Unknown
YGL056C	YGL056C	SDS23	hom	Verified	0.790186736307083	0.214709360478322	no	1108	0.21648029588305	731	NA	FT	CELL DIVISION	NUCLEUS		One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication	cytokinetic cell separation	molecular_function	nucleus|cytoplasm
YIL086C_d	YIL086C	YIL086C	hom	Dubious	0.789887267199149	0.214796804033375	no	1109	0.19830132235003	684	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR195C	YBR195C	MSI1	hom	Verified	0.789873221013281	0.21480090596076	no	1110	0.200018196950881	647	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase	DNA replication-dependent nucleosome assembly	histone binding	nucleus|CAF-1 complex|cytoplasm
YLR421C	YLR421C	RPN13	hom	Verified	0.789534262350413	0.214899906334639	no	1111	0.224399202052764	778	NA	FT	PROTEOLYSIS	NUCLEUS		Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress	ubiquitin-dependent protein catabolic process	ubiquitin binding	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YGR038W	YGR038W	ORM1	hom	Verified	0.789008016323768	0.215053660628124	no	1112	0.249149958450193	849	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control	cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein	molecular_function	integral to membrane|endoplasmic reticulum|SPOTS complex
YMR305C	YMR305C	SCW10	hom	Verified	0.787556948899625	0.215477952466512	no	1113	0.216635962289099	721	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM		Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p	conjugation with cellular fusion	glucosidase activity	fungal-type cell wall|extracellular region|endoplasmic reticulum|cytoplasm
YAL055W	YAL055W	PEX22	hom	Verified	0.787375292450678	0.215531102954217	no	1114	0.231234612177021	765	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation	protein import into peroxisome matrix, receptor recycling|protein targeting to peroxisome	protein anchor	integral to peroxisomal membrane
YDR350C	YDR350C	ATP22	hom	Verified	0.786899408917898	0.215670376785445	no	1115	0.225117711109548	776	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane	proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrial inner membrane
YDR089W	YDR089W	YDR089W	hom	Verified	0.785877986236243	0.215969486241084	no	1116	0.183490783586582	627	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress	cellular membrane organization	molecular_function	integral to membrane|membrane
YJL166W	YJL166W	QCR8	hom	Verified	0.783903317485971	0.216548421513104	no	1117	0.200027536425275	600	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YPR043W	YPR043W	RPL43A	hom	Verified	0.783828311976675	0.216570429385534	no	1118	0.167967625500318	579	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR223W	YDR223W	CRF1	hom	Verified	0.783688417267706	0.216611480292929	no	1119	0.216757165334853	716	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS	NUCLEUS|CHROMOSOME		Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter	transcription corepressor activity	nuclear chromatin|nucleus|cytoplasm
YNL081C	YNL081C	SWS2	hom	Verified	0.782361483562777	0.217001081424577	no	1120	0.263098025375868	905	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency	regulation of sporulation resulting in formation of a cellular spore|mitochondrial translation	structural constituent of ribosome	mitochondrial small ribosomal subunit|cytoplasm
YMR034C_p	YMR034C	YMR034C	hom	Uncharacterized	0.782129778997985	0.217069153731997	no	1121	0.226219200020026	730	NA					Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene	biological_process	sterol transporter activity	integral to membrane
YMR105W-A_p	YMR105W-A	YMR105W-A	hom	Uncharacterized	0.777813021545902	0.218339625116768	no	1122	0.254843953946569	892	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR148W	YMR148W	OSW5	hom	Verified	0.777352064667059	0.218475542694774	no	1123	0.169193060342257	559	NA					Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion	biological_process	molecular_function	integral to membrane
YDR093W	YDR093W	DNF2	hom	Verified	0.776754638647753	0.218651771990604	no	1124	0.206631746766309	709	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase	intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity	phospholipid-translocating ATPase activity	integral to membrane|plasma membrane
YNL218W	YNL218W	MGS1	hom	Verified	0.775864005346225	0.218914643710564	no	1125	0.177026566943684	579	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress	regulation of DNA repair|DNA replication, Okazaki fragment processing|DNA strand renaturation	ubiquitin binding|single-stranded DNA-dependent ATPase activity|enzyme activator activity	nucleus|cytoplasm
YLR441C	YLR441C	RPS1A	hom	Verified	0.775762382981395	0.218944649251056	no	1126	0.242041542408321	811	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YDR003W	YDR003W	RCR2	hom	Verified	0.775704192327944	0.218961831986873	no	1127	0.198730021016954	671	NA	FT	VESICLE-MEDIATED TRANSPORT			Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication	vesicle-mediated transport	molecular_function	vesicle|integral to membrane|fungal-type vacuole|cytoplasm
YKR066C	YKR066C	CCP1	hom	Verified	0.77491290176214	0.219195563955346	no	1128	0.222691895551531	752	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress	cellular response to oxidative stress	cytochrome-c peroxidase activity	mitochondrion|mitochondrial intermembrane space
YBL007C	YBL007C	SLA1	hom	Verified	0.774335771569683	0.219366127497349	no	1129	0.27235473401396	927	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains	fungal-type cell wall organization|endocytosis|actin cortical patch assembly	ubiquitin binding|protein binding, bridging	cell cortex|nucleus|mating projection tip|actin cortical patch
YHR021W-A_p	YHR021W-A	ECM12	hom	Uncharacterized	0.774335589601388	0.219366181287806	no	1130	0.210090463381997	706	NA	FT	CELL WALL ORG/BIOGENESIS			Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity	fungal-type cell wall organization	molecular_function	cellular_component
YGR149W_p	YGR149W	YGR149W	hom	Uncharacterized	0.770959557548952	0.220365451763859	no	1131	0.197240185537611	661	NA					Putative protein of unknown function; predicted to be an integal membrane protein	biological_process	molecular_function	integral to membrane
YDL011C_d	YDL011C	YDL011C	hom	Dubious	0.770810094851443	0.22040975140629	no	1132	0.206184557012052	697	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W	Unknown	Unknown	Unknown
YGR130C	YGR130C	YGR130C	hom	Verified	0.769161938728713	0.220898591108473	no	1133	0.24380652247026	832	NA					Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)	biological_process	molecular_function	eisosome|membrane raft|cytoplasm
YFL044C	YFL044C	OTU1	hom	Verified	0.767251140413224	0.221466106097089	no	1134	0.193427215070472	649	NA	FT	PROTEOLYSIS	NUCLEUS		Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress	protein deubiquitination|regulation of transcription, DNA-dependent	ubiquitin-specific protease activity	nucleus|cytoplasm
YMR221C_p	YMR221C	YMR221C	hom	Uncharacterized	0.766613630760432	0.221655634374839	no	1135	0.213740757322663	748	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy	biological_process	molecular_function	mitochondrion|integral to membrane|fungal-type vacuole
YJR152W	YJR152W	DAL5	hom	Verified	0.766537438648214	0.221678292089218	no	1136	0.216793163712552	715	NA	FT		PLASMA MEMBRANE		Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression	dipeptide transport|allantoate transport	dipeptide transporter activity|allantoate transmembrane transporter activity	integral to membrane|plasma membrane
YPL208W	YPL208W	RKM1	hom	Verified	0.763866622852884	0.222473364756389	no	1137	0.220430326331187	740	NA	FT		NUCLEUS		SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)	peptidyl-lysine dimethylation	protein-lysine N-methyltransferase activity	nucleus|cytoplasm
YOR090C	YOR090C	PTC5	hom	Verified	0.762398750131806	0.222911025995245	no	1138	0.228543600691843	719	NA	FT		MITOCHONDRION		Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p	positive regulation of catalytic activity|regulation of catalytic activity|protein dephosphorylation	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|protein serine/threonine phosphatase activity	mitochondrion
YKR017C	YKR017C	HEL1	hom	Verified	0.759481574064437	0.223782266165344	no	1139	0.230019120379261	792	NA					RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)	biological_process	molecular_function	cellular_component
YOR301W	YOR301W	RAX1	hom	Verified	0.759327913403472	0.223828211869499	no	1140	0.173010335330824	555	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily	cellular bud site selection	molecular_function	integral to membrane|cellular bud neck
YGR039W_d	YGR039W	YGR039W	hom	Dubious	0.757037173595206	0.224513795913492	no	1141	0.228888991834253	785	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722	Unknown	Unknown	Unknown
YGL027C	YGL027C	CWH41	hom	Verified	0.75566023334335	0.224926466168515	no	1142	0.248084265903926	848	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress	fungal-type cell wall biogenesis|protein N-linked glycosylation	mannosyl-oligosaccharide glucosidase activity	endoplasmic reticulum membrane
YMR036C	YMR036C	MIH1	hom	Verified	0.755454439206025	0.224988179770341	no	1143	0.192781060288069	640	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25	G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	protein tyrosine phosphatase activity	nucleus|cytoplasm
YER167W	YER167W	BCK2	hom	Verified	0.754682573885312	0.225219732428128	no	1144	0.255391336474987	888	NA	FT	CELL CYCLE	NUCLEUS		Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations	regulation of cell cycle|positive regulation of gene expression|G1/S transition of mitotic cell cycle	molecular_function	nucleus|cytoplasm
YCL001W-B_p	YCL001W-B	YCL001W-B	hom	Uncharacterized	0.754026391729651	0.225416687283693	no	1145	0.241895628469082	798	NA					Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YNR009W	YNR009W	NRM1	hom	Verified	0.752139759519835	0.225983507946424	no	1146	0.214012108388869	726	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase	negative regulation of transcription involved in G1 phase of mitotic cell cycle	repressing transcription factor binding|transcription factor binding transcription factor activity	MBF transcription complex|nucleus|cytoplasm
YNL265C	YNL265C	IST1	hom	Verified	0.751988820043703	0.226028891058473	no	1147	0.238856616898943	818	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p	late endosome to vacuole transport via multivesicular body sorting pathway	molecular_function	endosome|cytoplasm
YKR076W	YKR076W	ECM4	hom	Verified	0.751355748956304	0.226219293237373	no	1148	0.232202880216497	794	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS			Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	fungal-type cell wall organization|glutathione metabolic process	glutathione transferase activity	cytoplasm
YGL179C	YGL179C	TOS3	hom	Verified	0.7513398841868	0.226224065882057	no	1149	0.202149064290375	737	NA	FT	CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION			Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome	protein phosphorylation|glucose metabolic process	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YDR374C_p	YDR374C	YDR374C	hom	Uncharacterized	0.751129159861734	0.226287464088748	no	1150	0.200833855717807	676	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJL127C	YJL127C	SPT10	hom	Verified	0.750382976226074	0.226512040463829	no	1151	0.227751258099642	774	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS		Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box	DNA repair|negative regulation of transcription from RNA polymerase II promoter|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	histone acetyltransferase activity|sequence-specific DNA binding	nucleus
YMR064W	YMR064W	AEP1	hom	Verified	0.749835236198072	0.226676971990624	no	1152	0.257529908981241	884	NA	FT	TRANSLATION	MITOCHONDRION		Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase	regulation of translation	translation regulator activity	mitochondrion
YGL229C	YGL229C	SAP4	hom	Verified	0.749081682217572	0.226903987450551	no	1153	0.231584463931506	754	NA	FT	CELL CYCLE	MITOCHONDRION		Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p	G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	mitochondrion|cytoplasm
YDL188C	YDL188C	PPH22	hom	Verified	0.748743039597991	0.227006048579205	no	1154	0.22601397907675	740	NA	FT	CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CHROMOSOME		Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication	actin filament organization|budding cell bud growth|G1/S transition of mitotic cell cycle|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|regulation of translation	protein serine/threonine phosphatase activity	condensed nuclear chromosome, centromeric region
YLR192C	YLR192C	HCR1	hom	Verified	0.747381806407592	0.227416562181376	no	1155	0.271892438201348	937	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION			Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	translation initiation factor activity	eukaryotic translation initiation factor 3 complex
YDR205W	YDR205W	MSC2	hom	Verified	0.746986522280003	0.227535848207841	no	1156	0.233534169257147	813	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids	cellular zinc ion homeostasis|zinc ion transport|transmembrane transport	zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YGL163C	YGL163C	RAD54	hom	Verified	0.746543632171223	0.227669542273915	no	1157	0.297058978915944	999	NA	FF|FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS		DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress	positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|DNA translocase activity	nucleus
YIL045W	YIL045W	PIG2	hom	Verified	0.746064380541998	0.227814262500831	no	1158	0.213276289968079	728	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase	regulation of glycogen biosynthetic process	protein phosphatase type 1 regulator activity	cytoplasm
YGL049C	YGL049C	TIF4632	hom	Verified	0.745347200067469	0.228030927073856	no	1159	0.203620782210614	688	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION		RIBOSOME	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication	translational initiation|stress granule assembly	translation initiation factor binding|mRNA binding|translation initiation factor activity	eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YDR392W	YDR392W	SPT3	hom	Verified	0.744398509508829	0.228317710219383	no	1160	0.284068297787872	972	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters	conjugation with cellular fusion|histone acetylation|pseudohyphal growth|ascospore formation|chromatin modification|invasive growth in response to glucose limitation|transcription from RNA polymerase II promoter	transcription cofactor activity	SLIK (SAGA-like) complex|SAGA complex
YER053C	YER053C	PIC2	hom	Verified	0.739538329023877	0.229790087115151	no	1161	0.185214829019134	599	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature	phosphate ion transport|transmembrane transport	inorganic phosphate transmembrane transporter activity	mitochondrion|integral to membrane
YDR314C	YDR314C	RAD34	hom	Verified	0.738998534743286	0.229953943551971	no	1162	0.233772783507258	742	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in nucleotide excision repair (NER); homologous to RAD4	nucleotide-excision repair	molecular_function	nucleus
YDR452W	YDR452W	PPN1	hom	Verified	0.738960992343343	0.22996534211025	no	1163	0.277533963081039	888	NA	FT		NUCLEUS		Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress	polyphosphate catabolic process|polyphosphate metabolic process	endopolyphosphatase activity|exopolyphosphatase activity	fungal-type vacuole membrane|nucleus
YBR272C	YBR272C	HSM3	hom	Verified	0.737152393079308	0.230514840311989	no	1164	0.218065948403253	741	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation	mismatch repair|proteasome regulatory particle assembly	molecular_function	cytosol|proteasome regulatory particle, base subcomplex|nucleus|cytoplasm
YOR307C	YOR307C	SLY41	hom	Verified	0.736694539232413	0.230654064206192	no	1165	0.242396893480139	799	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM		Protein involved in ER-to-Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum
YDR181C	YDR181C	SAS4	hom	Verified	0.736332572562929	0.230764164035085	no	1166	0.272676197309348	931	NA	FT	CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p	chromatin silencing at telomere	acetyltransferase activity|histone acetyltransferase activity	nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YDR126W	YDR126W	SWF1	hom	Verified	0.735517498490939	0.231012193517582	no	1167	0.249159703937314	841	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|CYTOSKELETON		Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion	ascospore wall assembly|cortical actin cytoskeleton organization|establishment of cell polarity|vacuole fusion, non-autophagic|regulation of exocytosis|protein palmitoylation	palmitoyltransferase activity	integral to membrane|actin filament bundle|nuclear outer membrane-endoplasmic reticulum membrane network|actin cortical patch
YNL166C	YNL166C	BNI5	hom	Verified	0.735355516440926	0.231061502860013	no	1168	0.200372545967936	642	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner	septin ring assembly|cytokinesis	molecular_function	cellular bud neck septin ring|cellular bud neck
YHR092C	YHR092C	HXT4	hom	Verified	0.734243126035057	0.231400286922105	no	1169	0.191456918151655	654	NA	FT		PLASMA MEMBRANE		High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication	hexose transport	pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YGL242C_p	YGL242C	YGL242C	hom	Uncharacterized	0.731873503287155	0.232122890055924	no	1170	0.254080391164382	867	NA					Putative protein of unknown function; deletion mutant is viable	biological_process	molecular_function	cellular_component
YNL259C	YNL259C	ATX1	hom	Verified	0.731529803725771	0.232227803505168	no	1171	0.242560954948566	846	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS			Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake	copper ion transport|cellular response to oxidative stress|cellular iron ion homeostasis	copper chaperone activity	cytosol
YNL160W	YNL160W	YGP1	hom	Verified	0.731229383050514	0.232319527788182	no	1172	0.231098244805427	785	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS			Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p	cell wall assembly	molecular_function	extracellular region
YPL095C	YPL095C	EEB1	hom	Verified	0.73089138475006	0.232422749342339	no	1173	0.248623709082732	858	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication	medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process	short-chain carboxylesterase activity|alcohol O-octanoyltransferase activity	cellular_component
YER068W	YER068W	MOT2	hom	Verified	0.729454455571922	0.232861858828203	no	1174	0.248911617792126	831	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications	deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|protein polyubiquitination|protein ubiquitination	ubiquitin-protein ligase activity|sequence-specific DNA binding	CCR4-NOT core complex|cytoplasm
YIL028W_d	YIL028W	YIL028W	hom	Dubious	0.728447330851427	0.233169899394544	no	1175	0.241253157984983	789	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL163C	YPL163C	SVS1	hom	Verified	0.727619558225173	0.233423252354696	no	1176	0.236221163067594	790	NA					Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication	response to chemical stimulus	molecular_function	fungal-type cell wall|fungal-type vacuole
YIR038C	YIR038C	GTT1	hom	Verified	0.727079756746921	0.233588549401345	no	1177	0.233774389226063	848	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p	glutathione metabolic process	glutathione transferase activity|glutathione peroxidase activity	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum|plasma membrane
YDR124W_p	YDR124W	YDR124W	hom	Uncharacterized	0.726865739658146	0.233654103297313	no	1178	0.220099550092373	736	NA					Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor	biological_process	molecular_function	cellular_component
YOR127W	YOR127W	RGA1	hom	Verified	0.726005850027794	0.233917592137392	no	1179	0.240948344646368	821	NA	FT	SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress	budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth	Rho GTPase activator activity	cellular bud neck split septin rings
YDR386W	YDR386W	MUS81	hom	Verified	0.724567777207654	0.234358616501717	no	1180	0.28365540066058	973	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	crossover junction endodeoxyribonuclease activity|endonuclease activity	Holliday junction resolvase complex|nucleus
YHR176W	YHR176W	FMO1	hom	Verified	0.724210728017155	0.234468186667826	no	1181	0.234730504068553	814	NA	FT	OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins	protein folding	N,N-dimethylaniline monooxygenase activity	endoplasmic reticulum membrane
YPL062W_d	YPL062W	YPL062W	hom	Dubious	0.724199789421923	0.23447154391794	no	1182	0.260930704847578	900	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation	Unknown	Unknown	Unknown
YMR210W	YMR210W	YMR210W	hom	Verified	0.723447086722429	0.234702625680704	no	1183	0.200103166375342	635	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification	medium-chain fatty acid biosynthetic process	transferase activity, transferring acyl groups	cellular_component
YDL168W	YDL168W	SFA1	hom	Verified	0.722857624774168	0.234883679976634	no	1184	0.271890970812406	901	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress	furaldehyde metabolic process|formaldehyde catabolic process|amino acid catabolic process to alcohol via Ehrlich pathway	S-(hydroxymethyl)glutathione dehydrogenase activity|hydroxymethylfurfural reductase (NADH) activity|alcohol dehydrogenase (NAD) activity	mitochondrion|cytoplasm
YNR051C	YNR051C	BRE5	hom	Verified	0.722781011182821	0.234907217645709	no	1185	0.2337920557817	812	NA	FT	VESICLE-MEDIATED TRANSPORT			Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown	molecular_function	cytoplasm
YOR126C	YOR126C	IAH1	hom	Verified	0.721077723618026	0.235430847959522	no	1186	0.203505094561921	679	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing	acetate metabolic process	hydrolase activity, acting on ester bonds	cellular_component
YMR097C	YMR097C	MTG1	hom	Verified	0.720251696189087	0.235685019811543	no	1187	0.253902363082512	883	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals	mitochondrial translation	GTPase activity	mitochondrion|mitochondrial inner membrane
YMR222C	YMR222C	FSH2	hom	Verified	0.718554820157518	0.236207629606693	no	1188	0.228661827022048	780	NA					Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2	biological_process	molecular_function	cytoplasm
YBR021W	YBR021W	FUR4	hom	Verified	0.718048411971393	0.236363718534025	no	1189	0.291630888730263	1058	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation	uracil transport|transmembrane transport	uracil:cation symporter activity	integral to membrane|membrane raft|plasma membrane
YBL100W-C_p	YBL100W-C	YBL100W-C	hom	Uncharacterized	0.717700463382045	0.236470998760208	no	1190	0.23368712717664	810	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YGL192W	YGL192W	IME4	hom	Verified	0.716834913873761	0.236737982980865	no	1191	0.260212232430461	904	NA	FT	CELL CYCLE	NUCLEUS		Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids	meiosis|mRNA methylation	mRNA (N6-adenosine)-methyltransferase activity	cellular_component
YJL052W	YJL052W	TDH1	hom	Verified	0.715861438263521	0.237038455669582	no	1192	0.267961399046677	915	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress	gluconeogenesis|glycolysis	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YGL010W_p	YGL010W	YGL010W	hom	Uncharacterized	0.715841945749096	0.237044474362789	no	1193	0.236901507303068	794	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; YGL010W is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YBL066C	YBL066C	SEF1	hom	Verified	0.712609323682863	0.238043770328717	no	1194	0.20792297020969	715	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative transcription factor, has homolog in Kluyveromyces lactis	biological_process	molecular_function	cellular_component
YPR046W	YPR046W	MCM16	hom	Verified	0.712435110313323	0.238097690159107	no	1195	0.281959539790152	987	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YPL098C	YPL098C	MGR2	hom	Verified	0.712380357714319	0.238114637719857	no	1196	0.265081452309245	907	NA	FT		MITOCHONDRION		Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype)	protein import into mitochondrial matrix	molecular_function	mitochondrial inner membrane presequence translocase complex
YIR039C	YIR039C	YPS6	hom	Verified	0.712017289323208	0.238227034928584	no	1197	0.263135390909633	908	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	PLASMA MEMBRANE		Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance	fungal-type cell wall organization	aspartic-type endopeptidase activity	fungal-type cell wall
YJL065C	YJL065C	DLS1	hom	Verified	0.711737263139428	0.238313744124949	no	1198	0.266588281634353	912	NA	FT	GENE SILENCING	NUCLEUS		Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication	chromatin silencing at telomere	molecular_function	chromatin accessibility complex|nucleus
YLR123C_d	YLR123C	YLR123C	hom	Dubious	0.711254344064637	0.238463319046579	no	1199	0.212576950157716	717	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif	Unknown	Unknown	Unknown
YNL071W	YNL071W	LAT1	hom	Verified	0.710486933900923	0.238701115327367	no	1200	0.259954595743453	862	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA	acetyl-CoA biosynthetic process from pyruvate	dihydrolipoyllysine-residue acetyltransferase activity	mitochondrion|mitochondrial pyruvate dehydrogenase complex
YBR028C	YBR028C	YPK3	hom	Verified	0.709863474435412	0.238894401297011	no	1201	0.270751141173469	905	NA	FT	PROTEIN PHOSPHORYLATION			An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner	biological_process	protein kinase activity	cytoplasm
YBR301W	YBR301W	PAU24	hom	Verified	0.709759054048978	0.238926782250021	no	1202	0.230192061391601	784	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth	biological_process	molecular_function	fungal-type cell wall
YJL043W_p	YJL043W	YJL043W	hom	Uncharacterized	0.708488388674048	0.239321010149353	no	1203	0.196462250091399	674	NA	FT		MITOCHONDRION		Putative protein of unknown function; YJL043W is a non-essential gene	biological_process	molecular_function	mitochondrion|cytoplasm
YCL075W	YCL075W	YCL075W	hom	pseudogene	0.708424464416258	0.239340852233083	no	1204	0.217471884510283	761	NA	FT		NUCLEUS		Pseudogene: encodes fragment of Ty Pol protein	transposition, RNA-mediated	ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity	retrotransposon nucleocapsid
YCR007C_p	YCR007C	YCR007C	hom	Uncharacterized	0.708382404769833	0.239353908033579	no	1205	0.253793740002126	845	NA					Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene	biological_process	molecular_function	cellular_component
YBR022W	YBR022W	POA1	hom	Verified	0.707641973874661	0.239583810033953	no	1206	0.222038470243315	800	NA	FT	RNA PROCESSING			Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing	tRNA splicing, via endonucleolytic cleavage and ligation	phosphatase activity	cellular_component
YLR324W	YLR324W	PEX30	hom	Verified	0.707481828127125	0.239633550751642	no	1207	0.27036871466795	943	NA	FF|FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p	peroxisome organization	molecular_function	integral to membrane|peroxisome|integral to peroxisomal membrane
YMR177W	YMR177W	MMT1	hom	Verified	0.706708821234052	0.239873723277085	no	1208	0.241175990058104	853	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p	cellular iron ion homeostasis	molecular_function	mitochondrion|integral to membrane
YDR109C_p	YDR109C	YDR109C	hom	Uncharacterized	0.706414286807012	0.23996526938403	no	1209	0.223736879597884	759	NA	FT	CARBOHYDRATE METABOLISM			Putative kinase	biological_process	molecular_function	cellular_component
YLL059C_d	YLL059C	YLL059C	hom	Dubious	0.706388491361565	0.239973287936767	no	1210	0.261209860011025	902	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL247C_p	YPL247C	YPL247C	hom	Uncharacterized	0.705420011535204	0.240274447035984	no	1211	0.235892709266464	825	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest	biological_process	molecular_function	nucleus|cytoplasm
YNR072W	YNR072W	HXT17	hom	Verified	0.704978487241122	0.240411812022273	no	1212	0.23201317630901	824	NA	FT		PLASMA MEMBRANE		Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose	hexose transport	mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YDR467C_d	YDR467C	YDR467C	hom	Dubious	0.704833488180573	0.240456932784664	no	1213	0.246038724246067	830	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR319C_p	YDR319C	YFT2	hom	Uncharacterized	0.704642887996838	0.240516250705362	no	1214	0.236630363547665	810	NA					Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens	biological_process	molecular_function	integral to membrane
YOR065W	YOR065W	CYT1	hom	Verified	0.70380547657114	0.240776961336773	no	1215	0.222603388800539	751	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex	oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c	electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity	mitochondrion|mitochondrial respiratory chain|integral to membrane|mitochondrial inner membrane|mitochondrial respiratory chain complex III
YOL045W	YOL045W	PSK2	hom	Verified	0.702619919000413	0.241146322842493	no	1216	0.259680232382271	849	NA	FT	SIGNALING|TRANSLATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication	regulation of (1->6)-beta-D-glucan biosynthetic process|negative regulation of glycogen biosynthetic process|protein phosphorylation	protein serine/threonine kinase activity	mitochondrion|cytoplasm
YMR120C	YMR120C	ADE17	hom	Verified	0.702115434177776	0.24130358890556	no	1217	0.214948724562626	768	NA	FT	NUCLEOTIDE METABOLISM			Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity	cytosol|plasma membrane
YER056C	YER056C	FCY2	hom	Verified	0.701569508573718	0.241473836317492	no	1218	0.206838210898745	690	NA	FT		PLASMA MEMBRANE		Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress	cytosine transport|cytidine transport|purine nucleobase transport|transmembrane transport	nucleobase transmembrane transporter activity|cytidine transmembrane transporter activity	integral to membrane|plasma membrane
YOR225W_d	YOR225W	YOR225W	hom	Dubious	0.700617322008356	0.241770932652562	no	1219	0.246505381109682	866	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR094C	YLR094C	GIS3	hom	Verified	0.700592725807642	0.241778609659546	no	1220	0.26154102873631	868	NA	FT	SIGNALING	NUCLEUS		Protein of unknown function	intracellular signal transduction	molecular_function	nucleus|cytoplasm
YOL007C	YOL007C	CSI2	hom	Verified	0.700382431551112	0.241844252452402	no	1221	0.234094917509035	788	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene	biological_process	molecular_function	fungal-type vacuole|cellular bud neck
YER109C	YER109C	FLO8	hom	Verified	0.699767332592044	0.242036309452297	no	1222	0.220737305864455	717	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene	biofilm formation|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YPR170C_d	YPR170C	YPR170C	hom	Dubious	0.699015913157092	0.242271043023519	no	1223	0.300049730833113	982	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B	Unknown	Unknown	Unknown
YGR080W	YGR080W	TWF1	hom	Verified	0.697861098235638	0.24263203243765	no	1224	0.231276190154218	822	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly	bipolar cellular bud site selection|actin polymerization or depolymerization|sequestering of actin monomers	actin monomer binding	mating projection tip|actin cortical patch
YFL055W	YFL055W	AGP3	hom	Verified	0.697393283805074	0.242778351751499	no	1225	0.232891250199143	795	NA	FT		PLASMA MEMBRANE		Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YPL099C	YPL099C	AIM43	hom	Verified	0.696804131081898	0.242962690225022	no	1226	0.229177899052889	754	NA	FT		MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YJR097W	YJR097W	JJJ3	hom	Verified	0.695674997821424	0.243316193328693	no	1227	0.252963997166374	857	NA	FT		NUCLEUS		Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	ferrous iron binding	nucleus|cytoplasm
YOR106W	YOR106W	VAM3	hom	Verified	0.695448678497398	0.243387081619603	no	1228	0.276988669079893	968	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS			Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region	autophagic vacuole fusion|vesicle fusion with vacuole|piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle docking|vesicle fusion	protein homodimerization activity|SNAP receptor activity	SNARE complex|fungal-type vacuole membrane
YPR147C_p	YPR147C	YPR147C	hom	Uncharacterized	0.694489500103494	0.243687641651614	no	1229	0.251149535091174	884	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cytoplasm
YMR304C-A_d	YMR304C-A	YMR304C-A	hom	Dubious	0.694309276424412	0.243744137375502	no	1230	0.239888071797862	832	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10	Unknown	Unknown	Unknown
YPR023C	YPR023C	EAF3	hom	Verified	0.69342222460009	0.244022309483889	no	1231	0.218407822939149	766	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition	DNA repair|histone acetylation|regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|histone deacetylation	histone acetyltransferase activity	Rpd3S complex|histone acetyltransferase complex|Rpd3L complex|NuA4 histone acetyltransferase complex
YDL020C	YDL020C	RPN4	hom	Verified	0.693078440698337	0.244130163296124	no	1232	0.372710490648836	1217	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|regulation of DNA repair|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YMR158W	YMR158W	MRPS8	hom	Verified	0.69288304465824	0.244191475492478	no	1233	0.243149270976928	848	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YLR449W	YLR449W	FPR4	hom	Verified	0.692731402584156	0.244239064105481	no	1234	0.246766866418074	858	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones	histone peptidyl-prolyl isomerization|negative regulation of histone H3-K36 methylation|regulation of transcription by chromatin organization|chromatin silencing at rDNA|nucleosome assembly	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	chromatin|nucleus
YOR350C	YOR350C	MNE1	hom	Verified	0.692314024930531	0.244370072193856	no	1235	0.247985084961609	852	NA	FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA	Group I intron splicing	molecular_function	mitochondrion|ribonucleoprotein complex|mitochondrial matrix
YPR098C	YPR098C	YPR098C	hom	Verified	0.692301680616761	0.244373947450607	no	1236	0.264789579883261	912	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YNL099C	YNL099C	OCA1	hom	Verified	0.690033298030373	0.245086623839721	no	1237	0.262026382825586	903	NA	FF|FT	RESPONSE TO OXIDATIVE STRESS			Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA	cellular response to oxidative stress	protein tyrosine phosphatase activity	cytoplasm
YNL097C	YNL097C	PHO23	hom	Verified	0.689963296914771	0.245108634432348	no	1238	0.230636379879732	828	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|chromatin modification|positive regulation of transcription from RNA polymerase II promoter	methylated histone residue binding	histone deacetylase complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YBR074W_p	YBR074W	YBR074W	hom	Uncharacterized	0.689857652609837	0.245141854398077	no	1239	0.260282191574115	921	NA	FT	PROTEOLYSIS			Putative metalloprotease	biological_process	molecular_function	cellular_component
YER002W	YER002W	NOP16	hom	Verified	0.689185523802413	0.245353262721704	no	1240	0.259520486355144	874	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis	ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YKL081W	YKL081W	TEF4	hom	Verified	0.688941750711601	0.245429962203671	no	1241	0.25577677984725	859	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex	translational elongation	translation elongation factor activity	mitochondrion|ribosome|eukaryotic translation elongation factor 1 complex
YGL211W	YGL211W	NCS6	hom	Verified	0.688823115112242	0.245467293744504	no	1242	0.248837823096457	874	NA	FT	RNA PROCESSING	MITOCHONDRION		Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	tRNA wobble position uridine thiolation|protein urmylation|tRNA wobble uridine modification	tRNA binding	cytosol|mitochondrion
YGR192C	YGR192C	TDH3	hom	Verified	0.688823060438198	0.245467310949708	no	1243	0.251300557217642	841	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication	gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YBR261C	YBR261C	TAE1	hom	Verified	0.688711960419191	0.245502274006805	no	1244	0.215155812431087	724	NA	FT	TRANSLATION			AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm	cytoplasmic translation|N-terminal peptidyl-proline dimethylation	N-terminal protein N-methyltransferase activity	cytosol|cytoplasm
YOR071C	YOR071C	NRT1	hom	Verified	0.687772814716274	0.245797929023588	no	1245	0.233284022666468	811	NA	FT		PLASMA MEMBRANE		High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity	thiamine transport|nicotinamide riboside transport	nicotinamide riboside transporter activity	integral to membrane|plasma membrane
YGR112W	YGR112W	SHY1	hom	Verified	0.68692014864668	0.246066524609724	no	1246	0.219016210701958	730	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome	mitochondrial respiratory chain complex IV assembly|aerobic respiration	unfolded protein binding	mitochondrion|integral to membrane|mitochondrial inner membrane
YMR274C	YMR274C	RCE1	hom	Verified	0.686053818384813	0.246339585677483	no	1247	0.252430870578326	873	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone	CAAX-box protein processing|peptide pheromone maturation|protein processing	metalloendopeptidase activity	integral to endoplasmic reticulum membrane|integral to membrane
YPL014W_p	YPL014W	YPL014W	hom	Uncharacterized	0.684933886056299	0.246692820858358	no	1248	0.251006665642307	875	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YGL064C	YGL064C	MRH4	hom	Verified	0.684709494440748	0.246763628285693	no	1249	0.259417310154535	894	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	MITOCHONDRION		Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function	RNA metabolic process	RNA helicase activity	mitochondrion
YHL007C	YHL007C	STE20	hom	Verified	0.683740334744202	0.24706957439802	no	1250	0.253964322704708	895	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH		Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p	negative regulation of gene expression|osmosensory signaling pathway via Sho1 osmosensor|activation of MAPKKK activity|vacuole inheritance|protein phosphorylation|cellular bud site selection|cellular response to heat|regulation of exit from mitosis|pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|pseudohyphal growth|sterol import|stress granule assembly|invasive growth in response to glucose limitation|positive regulation of apoptotic process	histone serine kinase activity|MAP kinase kinase kinase kinase activity|protein kinase activity	incipient cellular bud site|plasma membrane|nucleus|mating projection tip
YBL091C-A	YBL091C-A	SCS22	hom	Verified	0.683705308967512	0.247080635197569	no	1251	0.247346237276706	859	NA	FT	LIPID METABOLISM			Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication	phospholipid biosynthetic process|chromatin silencing at telomere	molecular_function	cellular_component
YNL295W_p	YNL295W	YNL295W	hom	Uncharacterized	0.683441960297479	0.247163806627949	no	1252	0.21700705026128	709	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR192C	YDR192C	NUP42	hom	Verified	0.683232538547166	0.247229957411155	no	1253	0.249029511662971	834	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p	poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YFL034W_p	YFL034W	YFL034W	hom	Uncharacterized	0.68297442741055	0.247311500904235	no	1254	0.251028087331641	895	NA					Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk	biological_process	molecular_function	integral to membrane
YLR393W	YLR393W	ATP10	hom	Verified	0.682869543806556	0.247344640255931	no	1255	0.241005611860641	796	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6	mitochondrial proton-transporting ATP synthase complex assembly	unfolded protein binding	integral to mitochondrial membrane|mitochondrion|mitochondrial inner membrane
YER122C	YER122C	GLO3	hom	Verified	0.679583850619141	0.248383999035457	no	1256	0.252131445279462	868	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p	retrograde vesicle-mediated transport, Golgi to ER|COPI coating of Golgi vesicle|ER to Golgi vesicle-mediated transport	ARF GTPase activator activity	COPI-coated vesicle|endoplasmic reticulum-Golgi intermediate compartment|COPI vesicle coat
YLR244C	YLR244C	MAP1	hom	Verified	0.678868732961439	0.24861051928955	no	1257	0.263014678403328	870	NA	FT	PROTEOLYSIS		RIBOSOME	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p	negative regulation of gene expression|protein initiator methionine removal involved in protein maturation	metalloaminopeptidase activity|mRNA binding	cytosolic ribosome
YDR422C	YDR422C	SIP1	hom	Verified	0.678703015455799	0.248663027571055	no	1258	0.246427934082028	804	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION			Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions	signal transduction|protein phosphorylation|regulation of protein complex assembly	AMP-activated protein kinase activity	AMP-activated protein kinase complex|fungal-type vacuole
YJL134W	YJL134W	LCB3	hom	Verified	0.677651807809476	0.248996244615476	no	1259	0.241891300355589	789	NA	FT	LIPID METABOLISM|SIGNALING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication	calcium-mediated signaling|sphingolipid biosynthetic process	sphingosine-1-phosphate phosphatase activity	integral to membrane|endoplasmic reticulum
YJR126C	YJR126C	VPS70	hom	Verified	0.677627335053588	0.249004004940878	no	1260	0.23611602679977	783	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Protein of unknown function involved in vacuolar protein sorting	protein targeting to vacuole	molecular_function	cellular_component
YGR070W	YGR070W	ROM1	hom	Verified	0.67703591267611	0.249191584456609	no	1261	0.261035479681566	924	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP	small GTPase mediated signal transduction|activation of Rho GTPase activity	Rho guanyl-nucleotide exchange factor activity	intracellular
YDR477W	YDR477W	SNF1	hom	Verified	0.676997103697653	0.249203896001288	no	1262	0.245541365526245	807	NA	FT	KETONE METABOLISM|SIGNALING|TRANSLATION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation	negative regulation of translation|protein phosphorylation|replicative cell aging|signal transduction|biofilm formation|positive regulation of gluconeogenesis|pseudohyphal growth|cell adhesion|regulation of carbohydrate metabolic process|invasive growth in response to glucose limitation|cellular response to nitrogen starvation	AMP-activated protein kinase activity|protein kinase activity	mitochondrion|AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|fungal-type vacuole|cytoplasm
YPL023C	YPL023C	MET12	hom	Verified	0.675507841733028	0.249676585472433	no	1263	0.257705193468971	880	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR	biological_process	methylenetetrahydrofolate reductase (NADPH) activity	cellular_component
YLR352W_p	YLR352W	YLR352W	hom	Uncharacterized	0.675452791555135	0.249694067436632	no	1264	0.245668287105746	828	NA					Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene	biological_process	molecular_function	SCF ubiquitin ligase complex
YLR297W	YLR297W	YLR297W	hom	Verified	0.674612453867761	0.249961009261361	no	1265	0.24446746828295	854	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication	biological_process	molecular_function	fungal-type vacuole
YBR093C	YBR093C	PHO5	hom	Verified	0.674607768715848	0.249962497972006	no	1266	0.239747331816079	817	NA	FT	RESPONSE TO NUTRIENT LEVELS			Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2	cellular response to phosphate starvation|phosphate-containing compound metabolic process|regulation of cell size	nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|acid phosphatase activity	fungal-type cell wall|cell wall-bounded periplasmic space
YBR182C-A_p	YBR182C-A	YBR182C-A	hom	Uncharacterized	0.674264620608144	0.250071546340193	no	1267	0.260158500274744	904	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YIL099W	YIL099W	SGA1	hom	Verified	0.673084258728697	0.250446843882571	no	1268	0.245059585386944	821	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation	ascospore formation|glycogen catabolic process	glucan 1,4-alpha-glucosidase activity	fungal-type vacuole
YMR300C	YMR300C	ADE4	hom	Verified	0.672774657869761	0.250545331256129	no	1269	0.260429489794889	901	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway	'de novo' IMP biosynthetic process	amidophosphoribosyltransferase activity	cytoplasm
YMR224C	YMR224C	MRE11	hom	Verified	0.672591313971407	0.250603664600913	no	1270	0.260544867746446	889	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress	DNA repair|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|base-excision repair|ascospore formation|meiotic DNA double-strand break processing|double-strand break repair via break-induced replication|regulation of transcription during meiosis	3'-5' exonuclease activity|protein complex scaffold|double-stranded telomeric DNA binding|adenylate kinase activity|telomeric DNA binding|single-stranded telomeric DNA binding|endodeoxyribonuclease activity|G-quadruplex DNA binding|endonuclease activity	mitochondrion|nucleus|Mre11 complex
YER045C	YER045C	ACA1	hom	Verified	0.670234236642112	0.251354241037163	no	1271	0.2409043149355	836	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDR218C	YDR218C	SPR28	hom	Verified	0.669634688797709	0.25154534759078	no	1272	0.233069041101347	798	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation	sexual sporulation resulting in formation of a cellular spore	structural molecule activity	spindle microtubule|meiotic spindle|septin complex|prospore membrane|ascospore wall
YOL113W	YOL113W	SKM1	hom	Verified	0.669395532573885	0.251621600320794	no	1273	0.267182688347096	947	NA	FT	CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS|PLASMA MEMBRANE		Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth	negative regulation of gene expression|cytokinetic cell separation|protein phosphorylation|sterol import	protein serine/threonine kinase activity|protein kinase activity	plasma membrane|nucleus
YIL046W-A_p	YIL046W-A	YIL046W-A	hom	Uncharacterized	0.667153953422159	0.252336900052322	no	1274	0.245169370161374	839	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YDL027C_p	YDL027C	YDL027C	hom	Uncharacterized	0.66535285646534	0.252912415327668	no	1275	0.250780487864265	851	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene	biological_process	molecular_function	mitochondrion
YKL096C-B_p	YKL096C-B	YKL096C-B	hom	Uncharacterized	0.665223160871708	0.252953884383909	no	1276	0.268979810959652	890	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YNL225C	YNL225C	CNM67	hom	Verified	0.665038295367262	0.253012999731603	no	1277	0.282466408789469	980	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication	microtubule nucleation|mitotic spindle organization	structural constituent of cytoskeleton	outer plaque of spindle pole body|spindle pole body
YGR248W	YGR248W	SOL4	hom	Verified	0.664880029229617	0.253063615044347	no	1278	0.241133049495671	817	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	6-phosphogluconolactonase activity	cytosol|nucleus|cytoplasm
YDR532C	YDR532C	KRE28	hom	Verified	0.663917880493057	0.253371435756523	no	1279	0.280668903639297	936	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components	biological_process	molecular_function	chromosome, centromeric region|condensed nuclear chromosome kinetochore|spindle pole body
YNL217W_p	YNL217W	YNL217W	hom	Uncharacterized	0.66390957701775	0.253374093147714	no	1280	0.242377138948935	809	NA					Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate	biological_process	phosphatase activity	fungal-type vacuole
YNL085W	YNL085W	MKT1	hom	Verified	0.662979119274584	0.253671963671177	no	1281	0.249469990565813	859	NA	FT	RESPONSE TO DNA DAMAGE|TRANSLATION			Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress	positive regulation of translation|interspecies interaction between organisms|response to DNA damage stimulus	nuclease activity	polysome|cytoplasm
YOR141C	YOR141C	ARP8	hom	Verified	0.662653536120425	0.253776237104671	no	1282	0.256002261331739	919	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME|CYTOSKELETON		Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity	mitotic recombination|response to DNA damage stimulus|chromatin remodeling	mRNA binding|ATP-dependent 3'-5' DNA helicase activity	nucleus|Ino80 complex
YBR054W	YBR054W	YRO2	hom	Verified	0.662527051941247	0.25381675184036	no	1283	0.239465907025581	817	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane|cellular bud
YGR018C_p	YGR018C	YGR018C	hom	Uncharacterized	0.661489625760812	0.254149182740522	no	1284	0.227150596174281	764	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W	biological_process	molecular_function	cellular_component
YOL025W	YOL025W	LAG2	hom	Verified	0.659789424020567	0.254694485575979	no	1285	0.262222010645172	882	NA	FT		MITOCHONDRION		Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1	replicative cell aging|negative regulation of ubiquitin-protein ligase activity	molecular_function	mitochondrion
YMR179W	YMR179W	SPT21	hom	Verified	0.659639797089736	0.254742504484019	no	1286	0.268844739571019	925	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS		Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress	chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	molecular_function	nucleus
YMR107W	YMR107W	SPG4	hom	Verified	0.659336037389604	0.254840002910271	no	1287	0.231515685098415	827	NA					Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	biological_process	molecular_function	cellular_component
YAL018C_p	YAL018C	YAL018C	hom	Uncharacterized	0.659142801346335	0.254902036476146	no	1288	0.262866855434628	871	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YOR308C	YOR308C	SNU66	hom	Verified	0.659106076036015	0.254913827105881	no	1289	0.255303729489302	903	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1	maturation of 5S rRNA|mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YGL107C	YGL107C	RMD9	hom	Verified	0.658591628029727	0.255079020198674	no	1290	0.267249352232283	905	NA	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes	translational initiation|regulation of mRNA stability|aerobic respiration	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion
YNR027W	YNR027W	BUD17	hom	Verified	0.658478160320617	0.255115463062456	no	1291	0.266609374412822	924	NA	FT	CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM	NUCLEUS		Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)	pyridoxal phosphate biosynthetic process|cellular bud site selection	pyridoxal kinase activity	nucleus|cytoplasm
YHR156C	YHR156C	LIN1	hom	Verified	0.658098046345666	0.255237565579037	no	1292	0.258135133949914	893	NA	FT		NUCLEUS|CHROMOSOME		Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication	biological_process	protein binding	chromatin|nucleus|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YER044C-A	YER044C-A	MEI4	hom	Verified	0.657775103102207	0.255341327368609	no	1293	0.236844182488773	821	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores	meiotic DNA double-strand break formation	molecular_function	condensed nuclear chromosome
YKR016W	YKR016W	FCJ1	hom	Verified	0.65761636502813	0.255392338054494	no	1294	0.242344957613072	818	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane	cristae formation|protein import into mitochondrial intermembrane space	molecular_function	mitochondrion|mitochondrial inner membrane|mitochondrial crista|mitochondrial crista junction|integral to mitochondrial inner membrane
YOL004W	YOL004W	SIN3	hom	Verified	0.657548021962848	0.255414301827074	no	1295	0.257213756850554	898	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL DIVISION|GENE SILENCING	NUCLEUS|CHROMOSOME		Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of transcription during meiosis|regulation of DNA-dependent DNA replication initiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|double-strand break repair via nonhomologous end joining|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle	transcription coactivator activity|transcription corepressor activity	Sin3-type complex|Rpd3S complex|Rpd3L-Expanded complex|Rpd3L complex
YOL080C	YOL080C	REX4	hom	Verified	0.65628192543166	0.255821372427677	no	1296	0.235468877147152	783	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly	ribosomal large subunit assembly|rRNA processing	3'-5' exonuclease activity	nucleolus|nucleus
YDR245W	YDR245W	MNN10	hom	Verified	0.65623020138565	0.255838009745541	no	1297	0.259701328852279	909	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family	N-glycan processing|cell wall mannoprotein biosynthetic process|substituted mannan metabolic process|barrier septum assembly	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YOL116W	YOL116W	MSN1	hom	Verified	0.655897382079677	0.255945076373594	no	1298	0.259680219883111	883	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	nucleus
YBR219C_p	YBR219C	YBR219C	hom	Uncharacterized	0.655418315018495	0.256099231351164	no	1299	0.253294888382945	837	NA					Putative protein of unknown function; YBR219C is not an essential gene	biological_process	molecular_function	integral to membrane
YLL043W	YLL043W	FPS1	hom	Verified	0.65501872097944	0.25622785040176	no	1300	0.252034188687798	896	NA	FT	ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress	conjugation with cellular fusion|transport|arsenite transport|glycerol transport|acetate transport|response to arsenic-containing substance	glycerol transmembrane transporter activity|transporter activity	integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YPR153W	YPR153W	YPR153W	hom	Verified	0.6537195405736	0.256646255808258	no	1301	0.239457997581576	815	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YDR219C	YDR219C	MFB1	hom	Verified	0.653323322049446	0.256773930073828	no	1302	0.236894599769316	807	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|mitochondrion organization	molecular_function	extrinsic to mitochondrial outer membrane|SCF ubiquitin ligase complex
YJL178C	YJL178C	ATG27	hom	Verified	0.65331134781817	0.256777789068276	no	1303	0.250800471033078	867	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site	vesicle organization|peroxisome degradation|protein localization to pre-autophagosomal structure|CVT pathway|autophagic vacuole assembly	phosphatidylinositol-3-phosphate binding	trans-Golgi network|mitochondrion|pre-autophagosomal structure|membrane
YAL045C_d	YAL045C	YAL045C	hom	Dubious	0.653030172156323	0.256868413609355	no	1304	0.231535374569625	769	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A	Unknown	Unknown	Unknown
YKL103C	YKL103C	APE1	hom	Verified	0.652970455418115	0.256887662801915	no	1305	0.22738875706309	780	NA					Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress	vacuolar protein catabolic process	metalloaminopeptidase activity	fungal-type vacuole
YHR162W	YHR162W	MPC2	hom	Verified	0.652832365956138	0.25693217766301	no	1306	0.250031395218392	867	NA					Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|integral to mitochondrial inner membrane
YOL138C	YOL138C	RTC1	hom	Verified	0.65261437442638	0.257002458120608	no	1307	0.259538595753923	895	NA					Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif	biological_process	molecular_function	ribosome|fungal-type vacuole|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YGR203W	YGR203W	YCH1	hom	Verified	0.652521243252513	0.257032486654672	no	1308	0.25742681185848	864	NA	FT		NUCLEUS		Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	dephosphorylation	phosphatase activity|protein tyrosine phosphatase activity|thiosulfate sulfurtransferase activity	nucleus|cytoplasm
YOL013W-A_p	YOL013W-A	YOL013W-A	hom	Uncharacterized	0.652154779282252	0.257150664331994	no	1309	0.25660767888699	864	NA					Putative protein of unknown function; identified by SAGE	biological_process	molecular_function	integral to membrane
YCR060W	YCR060W	TAH1	hom	Verified	0.651625002311334	0.257321557284818	no	1310	0.248725662008807	819	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II	protein folding|box C/D snoRNP assembly	chaperone binding	R2TP complex|nucleus|cytoplasm
YDR221W	YDR221W	GTB1	hom	Verified	0.651324964814011	0.25741836813682	no	1311	0.247550976898596	849	NA	FT	CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM		Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress	polysaccharide biosynthetic process|protein N-linked glycosylation	alpha-glucosidase activity	glucosidase II complex|endoplasmic reticulum|endoplasmic reticulum lumen
YCR005C	YCR005C	CIT2	hom	Verified	0.651313948683233	0.257421922989359	no	1312	0.250012275876402	839	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication	glyoxylate cycle|glutamate biosynthetic process|citrate metabolic process	citrate (Si)-synthase activity	mitochondrion|peroxisome
YPR198W	YPR198W	SGE1	hom	Verified	0.651271541169169	0.257435607928727	no	1313	0.296553177911801	1021	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations	response to drug|drug transport	drug transmembrane transporter activity	integral to membrane|integral to plasma membrane
YMR225C	YMR225C	MRPL44	hom	Verified	0.651171225738214	0.257467981304597	no	1314	0.256978316400856	879	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDR491C_d	YDR491C	YDR491C	hom	Dubious	0.65096638731036	0.257534092472149	no	1315	0.227513037113434	777	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR465C	YDR465C	RMT2	hom	Verified	0.650962513484106	0.25753534282629	no	1316	0.283354467012006	956	NA	FT		NUCLEUS		Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress	peptidyl-arginine methylation	protein-arginine N5-methyltransferase activity	nucleus|cytoplasm
YJL049W_p	YJL049W	YJL049W	hom	Uncharacterized	0.650831044474941	0.257577778921832	no	1317	0.209390924003302	683	NA	FT	PROTEIN LOCALIZATION			Putative protein of unknown function; YJL049W is a non-essential gene	biological_process	molecular_function	cellular_component
YBR072W	YBR072W	HSP26	hom	Verified	0.650792561605476	0.257590201264242	no	1318	0.247919641826925	852	NA	FT		NUCLEUS		Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity	protein folding|response to stress	unfolded protein binding|mRNA binding	nucleus|cytoplasm
YIL157C	YIL157C	COA1	hom	Verified	0.650461888909542	0.257696955851501	no	1319	0.259457391176122	904	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly	mitochondrial respiratory chain complex IV assembly	molecular_function	integral to mitochondrial membrane|mitochondrion|integral to mitochondrial inner membrane
YOR275C	YOR275C	RIM20	hom	Verified	0.650434636725235	0.257705754988703	no	1320	0.249920452070227	862	NA	FT	ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS	NUCLEUS		Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation	proteolysis|response to pH|protein processing|invasive growth in response to glucose limitation|sporulation resulting in formation of a cellular spore	molecular_function	nucleus|cytoplasm
YOL119C	YOL119C	MCH4	hom	Verified	0.649918851954114	0.257872320072912	no	1321	0.234159289063092	769	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	fungal-type vacuole membrane|integral to membrane
YIL154C	YIL154C	IMP2'	hom	Verified	0.649862810600684	0.257890421165361	no	1322	0.312425469842023	1092	NA	FF|FT	RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS			Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat	DNA repair|cellular carbohydrate metabolic process	transcription coactivator activity	cytoplasm
YCL048W	YCL048W	SPS22	hom	Verified	0.648809944997433	0.258230614281858	no	1323	0.254157446302896	855	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall	ascospore wall assembly|fungal-type cell wall organization	molecular_function	plasma membrane
YGL006W	YGL006W	PMC1	hom	Verified	0.648447497598839	0.258347779049086	no	1324	0.24662388994899	845	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a	cellular calcium ion homeostasis|calcium ion transport|transmembrane transport	calcium-transporting ATPase activity	fungal-type vacuole membrane|integral to membrane
YDL134C	YDL134C	PPH21	hom	Verified	0.648209725424544	0.258424656256153	no	1325	0.236680784958277	801	NA	FT	CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION			Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication	actin filament organization|budding cell bud growth|protein dephosphorylation|G1/S transition of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|regulation of translation	protein serine/threonine phosphatase activity	protein phosphatase type 2A complex
YKR080W	YKR080W	MTD1	hom	Verified	0.64774881707241	0.258573712262165	no	1326	0.26925505257154	901	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline	folic acid-containing compound biosynthetic process|one-carbon metabolic process|purine nucleobase biosynthetic process	methylenetetrahydrofolate dehydrogenase (NAD+) activity	cytosol
YNL035C	YNL035C	YNL035C	hom	Verified	0.647594504521667	0.258623626299477	no	1327	0.232121072894669	793	NA	FT		NUCLEUS		Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YGL039W	YGL039W	YGL039W	hom	Verified	0.647586163051649	0.258626324578871	no	1328	0.232950864133105	778	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS			Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols	cellular ketone metabolic process|cellular aromatic compound metabolic process	oxidoreductase activity, acting on CH-OH group of donors|carbonyl reductase (NADPH) activity	cytoplasm
YJR153W	YJR153W	PGU1	hom	Verified	0.64751634660201	0.258648909213764	no	1329	0.235134573567187	769	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins	pseudohyphal growth|pectin catabolic process	polygalacturonase activity	extracellular region
YER076C_p	YER076C	YER076C	hom	Uncharacterized	0.647474912648347	0.258662312995055	no	1330	0.254689358744151	848	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization	biological_process	molecular_function	mitochondrion
YOL125W	YOL125W	TRM13	hom	Verified	0.647391602869871	0.258689264590235	no	1331	0.218070321075748	719	NA	FT	RNA PROCESSING	NUCLEUS		2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases	tRNA methylation	tRNA methyltransferase activity	nucleus|cytoplasm
YOR295W	YOR295W	UAF30	hom	Verified	0.646983364667065	0.258821354982437	no	1332	0.248022483681921	872	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|chromatin organization	RNA polymerase I upstream control element sequence-specific DNA binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity	nucleolus|RNA polymerase I upstream activating factor complex
YPR001W	YPR001W	CIT3	hom	Verified	0.646083245032028	0.259112722807404	no	1333	0.276772231887527	931	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate	propionate catabolic process, 2-methylcitrate cycle|propionate metabolic process|tricarboxylic acid cycle	2-methylcitrate synthase activity|citrate (Si)-synthase activity	mitochondrion
YPL221W	YPL221W	FLC1	hom	Verified	0.64530847766666	0.25936364996547	no	1334	0.252478845625681	863	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance	protein folding|fungal-type cell wall biogenesis|FAD transport	FAD transmembrane transporter activity	integral to membrane|endoplasmic reticulum|fungal-type vacuole|cellular bud neck
YMR206W_p	YMR206W	YMR206W	hom	Uncharacterized	0.64512722971377	0.259422369615594	no	1335	0.24398205898334	821	NA					Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YPL207W	YPL207W	TYW1	hom	Verified	0.644735017790676	0.259549459641369	no	1336	0.256391821409424	894	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM		Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron	wybutosine biosynthetic process	molecular_function	endoplasmic reticulum
YBR165W	YBR165W	UBS1	hom	Verified	0.644682340784596	0.259566531234628	no	1337	0.230370820971536	770	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity	protein export from nucleus|protein ubiquitination	molecular_function	nucleus
YPL134C	YPL134C	ODC1	hom	Verified	0.644635981660646	0.259581555804782	no	1338	0.250108365317769	869	NA	FT		MITOCHONDRION		Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation	mitochondrial transport	dicarboxylic acid transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YOR371C	YOR371C	GPB1	hom	Verified	0.644600810741617	0.25959295467909	no	1339	0.252021879461062	874	NA	FT	SIGNALING|PROTEOLYSIS	PLASMA MEMBRANE		Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication	positive regulation of Ras protein signal transduction|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of phosphorylation|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|invasive growth in response to glucose limitation|negative regulation of Ras protein signal transduction|protein polyubiquitination	cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding	plasma membrane|cytoplasm
YPL031C	YPL031C	PHO85	hom	Verified	0.643816314834592	0.259847276498466	no	1340	0.300352505917929	997	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES A	NUCLEUS		Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle	regulation of transcription involved in G1/S phase of mitotic cell cycle|negative regulation of calcium-mediated signaling|regulation of protein stability|regulation of protein localization|protein phosphorylation|response to DNA damage stimulus|negative regulation of phosphate metabolic process|fungal-type cell wall organization|regulation of establishment or maintenance of cell polarity|negative regulation of glycogen biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of macroautophagy|negative regulation of macroautophagy	protein kinase activity|cyclin-dependent protein kinase activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YNL023C	YNL023C	FAP1	hom	Verified	0.643214292357728	0.260042530301552	no	1341	0.235321399029031	805	NA	FT		NUCLEUS		Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1	biological_process	sequence-specific DNA binding transcription factor activity	cytoplasm
YKL220C	YKL220C	FRE2	hom	Verified	0.642745992264601	0.26019446625069	no	1342	0.232060849382846	765	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YML118W	YML118W	NGL3	hom	Verified	0.642216928009211	0.260366171636828	no	1343	0.230303112998777	795	NA					3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication	polyadenylation-dependent RNA catabolic process	poly(A)-specific ribonuclease activity|endonuclease activity	cellular_component
YJR078W	YJR078W	BNA2	hom	Verified	0.642178816431652	0.260378542828558	no	1344	0.237735656172735	814	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp	de novo NAD biosynthetic process from tryptophan	tryptophan 2,3-dioxygenase activity|indoleamine 2,3-dioxygenase activity	cytoplasm
YLR027C	YLR027C	AAT2	hom	Verified	0.642163479494367	0.260383521353724	no	1345	0.303279785814075	992	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells	aspartate biosynthetic process	L-aspartate:2-oxoglutarate aminotransferase activity	cytosol|peroxisome
YOR092W	YOR092W	ECM3	hom	Verified	0.641739435867666	0.26052118962617	no	1346	0.256377834660993	863	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication	fungal-type cell wall organization	ATPase activity	integral to membrane|endoplasmic reticulum
YKL097C_d	YKL097C	YKL097C	hom	Dubious	0.641677574700137	0.260541276352285	no	1347	0.244777595247827	830	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species	Unknown	Unknown	Unknown
YML096W_p	YML096W	YML096W	hom	Uncharacterized	0.641503784657866	0.260597711383298	no	1348	0.270888776352458	940	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10	biological_process	molecular_function	cytoplasm
YDR122W	YDR122W	KIN1	hom	Verified	0.641219865179949	0.260689922402642	no	1349	0.234241032705055	784	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	PLASMA MEMBRANE		Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p	protein autophosphorylation|exocytosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	internal side of plasma membrane|plasma membrane
YER064C	YER064C	VHR2	hom	Verified	0.641039998265183	0.260748348045666	no	1350	0.239486043125832	811	NA	FT		NUCLEUS		Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	regulation of transcription, DNA-dependent	molecular_function	nucleus
YJR135C	YJR135C	MCM22	hom	Verified	0.640745329329174	0.260844079051581	no	1351	0.247133256439723	840	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YOR101W	YOR101W	RAS1	hom	Verified	0.640081535493528	0.261059796272278	no	1352	0.228955177504436	811	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress	adenylate cyclase-activating G-protein coupled receptor signaling pathway|replicative cell aging|Ras protein signal transduction	GTPase activity	plasma membrane
YHR139C-A_d	YHR139C-A	YHR139C-A	hom	Dubious	0.639718708099565	0.261177745304764	no	1353	0.253194122504579	865	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR213W	YBR213W	MET8	hom	Verified	0.639147846383028	0.261363378192847	no	1354	0.283642729640288	966	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis	siroheme biosynthetic process|sulfate assimilation	precorrin-2 dehydrogenase activity|ferrochelatase activity	cellular_component
YML081W	YML081W	TDA9	hom	Verified	0.639023260789788	0.261403899959162	no	1355	0.245744478860398	829	NA	FT		NUCLEUS		DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication	biological_process	sequence-specific DNA binding	nucleus
YJR084W	YJR084W	YJR084W	hom	Verified	0.638899029439453	0.261444309719557	no	1356	0.236836250505568	792	NA	FT	RNA PROCESSING|SIGNALING	NUCLEUS|CHROMOSOME		Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|mRNA splicing, via spliceosome	molecular_function	transcriptionally active chromatin
YNL078W	YNL078W	NIS1	hom	Verified	0.638021253652129	0.26172992249606	no	1357	0.224416960667929	776	NA	FT	CELL CYCLE	NUCLEUS|SITE OF POLARIZED GROWTH		Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network	regulation of mitosis	molecular_function	nucleus|cellular bud neck
YDR094W_d	YDR094W	YDR094W	hom	Dubious	0.637504187181921	0.261898241708689	no	1358	0.232994096484522	797	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2	Unknown	Unknown	Unknown
YAL062W	YAL062W	GDH3	hom	Verified	0.637421425523199	0.261925188034301	no	1359	0.243504097186796	831	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS|MITOCHONDRION		NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication	glutamate biosynthetic process|ammonia assimilation cycle	glutamate dehydrogenase (NADP+) activity	mitochondrion|nucleus
YLL024C	YLL024C	SSA2	hom	Verified	0.636892924560722	0.262097295908102	no	1360	0.247128940388376	835	NA	FT	PROTEIN LOCALIZATION	MITOCHONDRION		ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity|ATP binding	cytosol|fungal-type vacuole membrane|mitochondrion|fungal-type cell wall|plasma membrane|polysome|chaperonin-containing T-complex|cytoplasm
YIR021W-A_p	YIR021W-A	YIR021W-A	hom	Uncharacterized	0.63673566412346	0.262148519413193	no	1361	0.264473505169521	911	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YOL013W-B_d	YOL013W-B	YOL013W-B	hom	Dubious	0.636483785473044	0.262230573031874	no	1362	0.238358571665773	829	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element	Unknown	Unknown	Unknown
YER170W	YER170W	ADK2	hom	Verified	0.63612136844994	0.262348659427765	no	1363	0.262647297991466	924	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background	nucleotide metabolic process	nucleoside triphosphate adenylate kinase activity|adenylate kinase activity	mitochondrion|mitochondrial inner membrane
YCL035C	YCL035C	GRX1	hom	Verified	0.636036914803705	0.262376180884573	no	1364	0.247291239704251	832	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	protein glutathionylation|cellular response to oxidative stress	disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity	nucleus|cytoplasm
YPL277C_p	YPL277C	YPL277C	hom	Uncharacterized	0.635389375686798	0.26258724776642	no	1365	0.248358870027661	850	NA					Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels	biological_process	molecular_function	membrane
YPR014C_d	YPR014C	YPR014C	hom	Dubious	0.635140063249434	0.26266853489726	no	1366	0.246274031431807	882	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene	Unknown	Unknown	Unknown
YDL222C	YDL222C	FMP45	hom	Verified	0.634920791535466	0.262740038033167	no	1367	0.232783195909868	780	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C	fungal-type cell wall organization|ascospore formation	molecular_function	cell cortex|mitochondrion|integral to membrane|plasma membrane
YJR100C	YJR100C	AIM25	hom	Verified	0.63462322200434	0.262837089520026	no	1368	0.244915548192173	823	NA	FT		MITOCHONDRION		Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YFR013W	YFR013W	IOC3	hom	Verified	0.63449144267585	0.262880074843039	no	1369	0.307826207059477	1034	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication	chromatin remodeling	nucleosome binding|ATPase activity|DNA binding	ISW1 complex
YNL052W	YNL052W	COX5A	hom	Verified	0.633783071437589	0.263111201238643	no	1370	0.244968951165104	831	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YNR015W	YNR015W	SMM1	hom	Verified	0.633749796176114	0.263122060798043	no	1371	0.234129093233466	809	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	NUCLEUS		Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs	tRNA processing|tRNA modification	tRNA dihydrouridine synthase activity	nucleus|cytoplasm
YGL263W	YGL263W	COS12	hom	Verified	0.633271203525667	0.263278277397668	no	1372	0.235745792450751	780	NA					Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	integral to membrane
YDR420W	YDR420W	HKR1	hom	Verified	0.632886934986186	0.26340374010214	no	1373	0.245148811441237	838	NA	FT	CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection	(1->3)-beta-D-glucan biosynthetic process|fungal-type cell wall organization|osmosensory signaling pathway via Sho1 osmosensor|hyperosmotic response|cellular bud site selection	osmosensor activity	site of polarized growth|plasma membrane
YCR030C	YCR030C	SYP1	hom	Verified	0.631972956580353	0.263702274324168	no	1374	0.246397650246254	801	NA	FT	CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization	septin cytoskeleton organization|actin cortical patch assembly	molecular_function	mating projection base|mating projection tip|cellular bud neck|cellular bud tip
YDR417C_d	YDR417C	YDR417C	hom	Dubious	0.631681853916005	0.263797393875267	no	1375	0.270123276151497	916	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W	Unknown	Unknown	Unknown
YKR053C	YKR053C	YSR3	hom	Verified	0.630939293090599	0.264040109313225	no	1376	0.271296944049364	946	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication	phospholipid dephosphorylation|sphingolipid biosynthetic process	sphingosine-1-phosphate phosphatase activity	integral to membrane|endoplasmic reticulum
YJL075C_d	YJL075C	APQ13	hom	Dubious	0.629685680322188	0.264450126627303	no	1377	0.265513758898135	892	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate	Unknown	Unknown	Unknown
YPR093C	YPR093C	ASR1	hom	Verified	0.629480955752217	0.264517116362604	no	1378	0.263957698891601	902	NA	FT		NUCLEUS		Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein	response to ethanol|protein ubiquitination	ubiquitin-protein ligase activity	nucleus|cytoplasm
YDL073W_p	YDL073W	YDL073W	hom	Uncharacterized	0.62901797334611	0.264668644763294	no	1379	0.295454641780936	1053	NA					Putative protein of unknown function; YDL073W is not an essential gene	biological_process	molecular_function	cellular_component
YMR265C_p	YMR265C	YMR265C	hom	Uncharacterized	0.626426479303113	0.26551762298941	no	1380	0.261707324017414	923	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKL175W	YKL175W	ZRT3	hom	Verified	0.626027604383297	0.265648417725254	no	1381	0.24833457476779	798	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency	cellular zinc ion homeostasis|zinc ion transport	zinc ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YGL260W_p	YGL260W	YGL260W	hom	Uncharacterized	0.625688313383718	0.265759700058699	no	1382	0.251917268731238	863	NA					Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium	biological_process	molecular_function	cellular_component
YNL109W_d	YNL109W	YNL109W	hom	Dubious	0.62320036956523	0.266576429447278	no	1383	0.27233121506795	925	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C	Unknown	Unknown	Unknown
YOL086W-A	YOL086W-A	MHF1	hom	Verified	0.6228780300895	0.266682338189887	no	1384	0.235773949786651	829	NA	FT	RESPONSE TO DNA DAMAGE			Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1	response to DNA damage stimulus	molecular_function	cellular_component
YNL243W	YNL243W	SLA2	hom	Verified	0.622600132896967	0.266773661924551	no	1385	0.268468408375121	899	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo	bipolar cellular bud site selection|fungal-type cell wall organization|actin filament organization|endocytosis|exocytosis	protein binding, bridging	incipient cellular bud site|mating projection tip|actin cortical patch
YMR139W	YMR139W	RIM11	hom	Verified	0.622367451298201	0.266850138876965	no	1386	0.227538336309266	789	NA	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION			Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress	proteolysis|ascospore formation|protein phosphorylation|response to stress	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YNL032W	YNL032W	SIW14	hom	Verified	0.621676312060238	0.267077365338829	no	1387	0.261190822907991	907	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION			Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm	actin filament organization|endocytosis|protein dephosphorylation|response to stress	protein tyrosine phosphatase activity	cytoplasm
YOR346W	YOR346W	REV1	hom	Verified	0.62077748992565	0.267373017958131	no	1388	0.242963453852786	803	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress	error-prone translesion synthesis|error-free translesion synthesis	deoxycytidyl transferase activity|DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|replication fork
YML100W	YML100W	TSL1	hom	Verified	0.620539610624154	0.26745129202577	no	1389	0.233969670398757	777	NA	FT	CARBOHYDRATE METABOLISM			Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication	trehalose biosynthetic process|response to stress	enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YDL107W	YDL107W	MSS2	hom	Verified	0.619256319206623	0.267873757682442	no	1390	0.273079722898158	968	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p	protein insertion into mitochondrial membrane from inner side	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrial matrix
YDR254W	YDR254W	CHL4	hom	Verified	0.618938175478109	0.267978544085377	no	1391	0.265356222934221	867	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15	kinetochore assembly|chromosome segregation|establishment of meiotic sister chromatid cohesion|protein localization to chromosome, centromeric region|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	structural molecule activity	condensed nuclear chromosome outer kinetochore
YNR029C_p	YNR029C	YNR029C	hom	Uncharacterized	0.618886538798694	0.267995553508216	no	1392	0.247328353066066	873	NA					Putative protein of unknown function, deletion confers reduced fitness in saline	biological_process	molecular_function	cytoplasm
YIL014W	YIL014W	MNT3	hom	Verified	0.618483220310264	0.26812842766839	no	1393	0.243314022156764	864	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation	protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	cellular_component
YNL275W	YNL275W	BOR1	hom	Verified	0.617710547795297	0.268383078896631	no	1394	0.261061849953837	879	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1	borate transport|protein targeting to vacuole	borate efflux transmembrane transporter activity	integral to membrane|plasma membrane|fungal-type vacuole
YGL083W	YGL083W	SCY1	hom	Verified	0.616587879928657	0.268753295412958	no	1395	0.254997766492286	855	NA	FT	PROTEIN PHOSPHORYLATION			Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase	biological_process	molecular_function	clathrin-coated vesicle
YJL207C	YJL207C	LAA1	hom	Verified	0.616544116825977	0.268767732143764	no	1396	0.271375586715025	923	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene	protein localization|retrograde transport, endosome to Golgi	molecular_function	AP-1 adaptor complex|ribosome|clathrin-coated vesicle
YDR447C	YDR447C	RPS17B	hom	Verified	0.616310892700251	0.268844675532119	no	1397	0.263804050944277	904	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit
YOR333C_d	YOR333C	YOR333C	hom	Dubious	0.614894480082354	0.269312204219282	no	1398	0.252251044691115	862	NA					Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth	Unknown	Unknown	Unknown
YJR115W_p	YJR115W	YJR115W	hom	Uncharacterized	0.614355000533905	0.269490382486293	no	1399	0.249212509426856	849	NA					Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YOL110W	YOL110W	SHR5	hom	Verified	0.613870466260874	0.269650463881167	no	1400	0.269486599517268	932	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization	protein targeting to membrane|protein palmitoylation	palmitoyltransferase activity	endoplasmic reticulum palmitoyltransferase complex|extrinsic to endoplasmic reticulum membrane
YMR104C	YMR104C	YPK2	hom	Verified	0.613632292390856	0.269729169696157	no	1401	0.228132513542187	765	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication	eisosome assembly|protein phosphorylation	protein kinase activity	nucleus|cytoplasm
YPR095C	YPR095C	SYT1	hom	Verified	0.613460949342882	0.269785798027485	no	1402	0.278238051404622	973	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING	MITOCHONDRION|GOLGI APPARATUS		Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain	vesicle-mediated transport|exocytosis|positive regulation of ARF protein signal transduction	ARF guanyl-nucleotide exchange factor activity	mitochondrion|Golgi apparatus part
YPL150W_p	YPL150W	YPL150W	hom	Uncharacterized	0.61253322774391	0.270092510401447	no	1403	0.241265751659952	803	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study	protein phosphorylation	protein kinase activity	cellular_component
YOL046C_d	YOL046C	YOL046C	hom	Dubious	0.612129445911475	0.270226058452076	no	1404	0.242540242160283	836	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W	Unknown	Unknown	Unknown
YJL141C	YJL141C	YAK1	hom	Verified	0.612032963527552	0.270257974220883	no	1405	0.258689369958755	900	NA	FT	PROTEIN PHOSPHORYLATION	NUCLEUS		Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose	protein phosphorylation	protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity	nucleus|cytoplasm
YER166W	YER166W	DNF1	hom	Verified	0.610702525310436	0.270698266956826	no	1406	0.284714942859114	958	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|GOLGI APPARATUS|PLASMA MEMBRANE		Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase	intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity	phospholipid-translocating ATPase activity|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	mitochondrion|integral to membrane|plasma membrane
YAL064C-A_p	YAL064C-A	TDA8	hom	Uncharacterized	0.61068383241729	0.270704455698568	no	1407	0.252273924132955	852	NA					Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene	biological_process	molecular_function	cellular_component
YNR018W	YNR018W	RCF2	hom	Verified	0.610578093141184	0.270739464615025	no	1408	0.26356809046095	867	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion|mitochondrial respiratory chain supercomplex|mitochondrial respiratory chain complex IV|integral to mitochondrial inner membrane
YML005W	YML005W	TRM12	hom	Verified	0.610301417662175	0.270831079007347	no	1409	0.298199916185359	1008	NA	FT	RNA PROCESSING			S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA	wybutosine biosynthetic process|tRNA methylation	S-adenosylmethionine-dependent methyltransferase activity|transferase activity, transferring alkyl or aryl (other than methyl) groups	cytoplasm
YGR194C	YGR194C	XKS1	hom	Verified	0.610271325994714	0.270841044068036	no	1410	0.243768998690982	853	NA	FT	CARBOHYDRATE METABOLISM			Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains	xylulose catabolic process	xylulokinase activity	cytoplasm
YGR207C	YGR207C	CIR1	hom	Verified	0.60956425278234	0.271075248836806	no	1411	0.234540741550519	770	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YKR007W	YKR007W	MEH1	hom	Verified	0.609078100439693	0.271236336281049	no	1412	0.282541541364456	973	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS			Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification	microautophagy|vacuolar acidification	molecular_function	fungal-type vacuole membrane|EGO complex|late endosome membrane
YHR003C	YHR003C	YHR003C	hom	Verified	0.608949488639696	0.271278960010619	no	1413	0.229737596577493	773	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YER181C_d	YER181C	YER181C	hom	Dubious	0.607851607458372	0.271642948856584	no	1414	0.264324311681058	908	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies	Unknown	Unknown	Unknown
YLL006W	YLL006W	MMM1	hom	Verified	0.607700833429894	0.271692955092448	no	1415	0.309089658015135	1048	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth	mitochondrion organization|mitochondrial genome maintenance|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrion|integral to endoplasmic reticulum membrane|ERMES complex
YNR057C	YNR057C	BIO4	hom	Verified	0.607406367568954	0.271790631871038	no	1416	0.290792444377903	1001	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM			Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels	biotin biosynthetic process	dethiobiotin synthase activity	cytoplasm
YNL025C	YNL025C	SSN8	hom	Verified	0.60734320865644	0.271811584484189	no	1417	0.285284454785657	971	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance	positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter	cyclin-dependent protein kinase regulator activity	mediator complex
YGR007W	YGR007W	ECT1	hom	Verified	0.606795975715709	0.271993159572389	no	1418	0.277194588677275	929	NA	FT	LIPID METABOLISM	NUCLEUS		Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases	phosphatidylethanolamine biosynthetic process	ethanolamine-phosphate cytidylyltransferase activity	nucleus|cytoplasm
YMR099C	YMR099C	YMR099C	hom	Verified	0.606379643594614	0.272131341396862	no	1419	0.289583874492542	1000	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS	cellular carbohydrate metabolic process	glucose-6-phosphate 1-epimerase activity	nucleus|cytoplasm
YDL218W_p	YDL218W	YDL218W	hom	Uncharacterized	0.605860447714651	0.272303712880225	no	1420	0.227715048341957	803	NA					Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin	biological_process	molecular_function	integral to membrane|cytoplasm
YFL003C	YFL003C	MSH4	hom	Verified	0.605811673178993	0.272319908667555	no	1421	0.239835157620313	777	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein	reciprocal meiotic recombination	DNA binding	nuclear chromosome
YBR056W	YBR056W	YBR056W	hom	Verified	0.605511266703512	0.272419670436396	no	1422	0.256262406526718	879	NA	FT	CARBOHYDRATE METABOLISM			Putative glycoside hydrolase of the mitochondrial intermembrane space	biological_process	molecular_function	cytoplasm
YGR292W	YGR292W	MAL12	hom	Verified	0.605142504232039	0.272542157310258	no	1423	0.24232453250837	822	NA	FT	CARBOHYDRATE METABOLISM			Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose	sucrose catabolic process|maltose catabolic process	sucrose alpha-glucosidase activity|maltose alpha-glucosidase activity	plasma membrane
YOR280C	YOR280C	FSH3	hom	Verified	0.604688850509204	0.272692878869336	no	1424	0.269822610902122	916	NA					Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2	biological_process	molecular_function	cellular_component
YKL047W_p	YKL047W	ANR2	hom	Uncharacterized	0.604319715202797	0.272815550609669	no	1425	0.272196895441816	953	NA					Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YBR210W	YBR210W	ERV15	hom	Verified	0.604151339266177	0.272871514707629	no	1426	0.253817219308703	843	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION			Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|axial cellular bud site selection	molecular_function	integral to membrane|ER to Golgi transport vesicle
YPR029C	YPR029C	APL4	hom	Verified	0.604141777871171	0.272874692855423	no	1427	0.250156942178404	858	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YOL122C	YOL122C	SMF1	hom	Verified	0.603410791487661	0.27311772248882	no	1428	0.26027315783558	886	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins	copper ion transport|cellular copper ion homeostasis|manganese ion transport|cadmium ion transport|cellular manganese ion homeostasis|cellular cadmium ion homeostasis|iron ion transport	solute:hydrogen symporter activity|inorganic cation transmembrane transporter activity	integral to membrane|plasma membrane
YJR111C_p	YJR111C	YJR111C	hom	Uncharacterized	0.603084254553429	0.273226320244458	no	1429	0.265873671240597	930	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria	biological_process	molecular_function	mitochondrion
YMR246W	YMR246W	FAA4	hom	Verified	0.601215853086875	0.273848113433515	no	1430	0.268348520317786	925	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM			Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication	long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process	long-chain fatty acid-CoA ligase activity	lipid particle|cytoplasm
YDR421W	YDR421W	ARO80	hom	Verified	0.601109840756524	0.273883414687736	no	1431	0.239760586903355	787	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids	aromatic amino acid family catabolic process|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|nucleic acid binding transcription factor activity	nucleus
YDR481C	YDR481C	PHO8	hom	Verified	0.600752262437314	0.274002501984672	no	1432	0.298387561641376	1025	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN	nicotinamide nucleotide metabolic process|protein dephosphorylation	nucleotide phosphatase activity|alkaline phosphatase activity	fungal-type vacuole membrane
YBR105C	YBR105C	VID24	hom	Verified	0.6005754331186	0.274061402385934	no	1433	0.284860921660749	984	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles	negative regulation of gluconeogenesis|vesicle fusion with vacuole|vacuolar protein catabolic process|proteasomal ubiquitin-dependent protein catabolic process|vesicle-mediated transport|protein targeting to vacuole	molecular_function	cytoplasmic membrane-bounded vesicle|GID complex|extrinsic to membrane
YLR329W	YLR329W	REC102	hom	Verified	0.599449283081874	0.274436660489502	no	1434	0.290358513160052	991	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome|nucleus
YKR093W	YKR093W	PTR2	hom	Verified	0.598306032261827	0.27481787616305	no	1435	0.301451259807053	1054	NA	FF|FT	PROTEIN LOCALIZATION	PLASMA MEMBRANE		Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p	dipeptide transport|tripeptide transport|peptide transport	dipeptide transporter activity|tripeptide transporter activity|peptide transporter activity	integral to membrane|plasma membrane
YEL013W	YEL013W	VAC8	hom	Verified	0.59691413400171	0.275282355121743	no	1436	0.261774431379591	906	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions	piecemeal microautophagy of nucleus|vacuole inheritance|CVT vesicle assembly|vacuole fusion, non-autophagic|macroautophagy|nucleus-vacuole junction assembly	protein anchor	fungal-type vacuole membrane|nucleus-vacuole junction|Myo2p-Vac17p-Vac8p transport complex
YGL058W	YGL058W	RAD6	hom	Verified	0.595076467518132	0.275896178977488	no	1437	0.285833312837346	983	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEOLYSIS|GENE SILENCING	NUCLEUS|CHROMOSOME		Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p	protein ubiquitination involved in ubiquitin-dependent protein catabolic process|histone monoubiquitination|protein monoubiquitination|error-free translesion synthesis|error-prone translesion synthesis|transcription from RNA polymerase II promoter|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of dipeptide transport|meiotic DNA double-strand break formation|ubiquitin-dependent protein catabolic process via the N-end rule pathway|double-strand break repair via homologous recombination|protein polyubiquitination|error-free postreplication DNA repair|chromatin silencing at telomere	ubiquitin-protein ligase activity	nuclear chromatin|proteasome complex|nucleus|cytoplasm
YGR263C	YGR263C	SAY1	hom	Verified	0.595000154494936	0.27592168385678	no	1438	0.288847511259239	959	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum	response to toxin|sterol metabolic process|sterol deacetylation	steryl deacetylase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YIL156W	YIL156W	UBP7	hom	Verified	0.594703376131045	0.27602088234394	no	1439	0.281627738459558	959	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease that cleaves ubiquitin-protein fusions	protein deubiquitination	ubiquitin-specific protease activity	cytoplasm
YBR107C	YBR107C	IML3	hom	Verified	0.594509042035886	0.276085848211123	no	1440	0.262117575010901	929	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1	establishment of meiotic sister chromatid cohesion|ascospore formation|protein localization to chromosome, centromeric region|meiotic sister chromatid segregation|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome outer kinetochore
YOL071W	YOL071W	EMI5	hom	Verified	0.593558845508158	0.276403606855215	no	1441	0.237022770841971	800	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)	protein-FAD linkage|cellular respiration|mitochondrial electron transport, succinate to ubiquinone|ascospore formation|tricarboxylic acid cycle|positive regulation of transcription from RNA polymerase II promoter	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial matrix
YFL016C	YFL016C	MDJ1	hom	Verified	0.593354912224005	0.276471828291742	no	1442	0.344678510697099	1131	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones	protein refolding|response to heat|misfolded or incompletely synthesized protein catabolic process|mitochondrial genome maintenance|'de novo' protein folding	unfolded protein binding|ATPase activator activity	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YGR100W	YGR100W	MDR1	hom	Verified	0.593214477568368	0.276518812445831	no	1443	0.283989871048846	989	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM			Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function	intracellular protein transport	Rab GTPase activator activity	cytoplasm
YEL046C	YEL046C	GLY1	hom	Verified	0.592300450388915	0.27682470718297	no	1444	0.312070280354557	1035	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis	threonine catabolic process|glycine biosynthetic process	threonine aldolase activity|L-allo-threonine aldolase activity	cytosol
YDL099W	YDL099W	BUG1	hom	Verified	0.590434045759977	0.277449845518573	no	1445	0.246255489390231	869	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	GOLGI APPARATUS		Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes	protein secretion|ER to Golgi vesicle-mediated transport	molecular_function	cis-Golgi network|cytoplasm
YOL136C	YOL136C	PFK27	hom	Verified	0.590217726499331	0.27752234464515	no	1446	0.259151357651317	888	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YMR080C	YMR080C	NAM7	hom	Verified	0.589862432544642	0.27764144105166	no	1447	0.29428197174856	1001	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RNA LOCALIZATION|GENE SILENCING	NUCLEUS		ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|intracellular mRNA localization|translational frameshifting|regulation of translational termination|chromatin silencing at silent mating-type cassette|protein ubiquitination	RNA-dependent ATPase activity|ATP-dependent RNA helicase activity|nucleic acid binding	mitochondrion|polysome|cytoplasm
YLR054C	YLR054C	OSW2	hom	Verified	0.588629531376566	0.278054909561383	no	1448	0.283635212066647	977	NA	FT	CELL WALL ORG/BIOGENESIS			Protein of unknown function proposed to be involved in the assembly of the spore wall	ascospore wall assembly	molecular_function	integral to membrane|prospore membrane|cytoplasm
YLR342W	YLR342W	FKS1	hom	Verified	0.587579593472434	0.278407255774094	no	1449	0.280107896882253	974	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON		Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling	(1->3)-beta-D-glucan biosynthetic process|positive regulation of endocytosis|regulation of cell size	1,3-beta-D-glucan synthase activity	mitochondrion|1,3-beta-D-glucan synthase complex|integral to membrane|plasma membrane|cellular bud neck|cellular bud tip|actin cortical patch
YPR017C	YPR017C	DSS4	hom	Verified	0.587257468836102	0.278515400430123	no	1450	0.290169231603982	976	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING			Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol	post-Golgi vesicle-mediated transport	zinc ion binding|guanyl-nucleotide exchange factor activity	cytosol|membrane
YNL067W-B_p	YNL067W-B	YNL067W-B	hom	Uncharacterized	0.58666018516592	0.278715976441644	no	1451	0.294050973612003	1029	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR005W	YBR005W	RCR1	hom	Verified	0.586281199366059	0.278843281502919	no	1452	0.263393659535741	924	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication	fungal-type cell wall organization|vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane
YDL243C	YDL243C	AAD4	hom	Verified	0.585661053782115	0.279051655523122	no	1453	0.27295632168858	938	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YOR297C	YOR297C	TIM18	hom	Verified	0.585455198513144	0.279120841323875	no	1454	0.250814823410929	867	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex	cellular response to oxidative stress|protein import into mitochondrial inner membrane|apoptotic process|response to acid|response to osmotic stress|response to arsenic-containing substance	protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YNL140C_p	YNL140C	YNL140C	hom	Uncharacterized	0.585277914431325	0.279180431330814	no	1455	0.32400930061705	1099	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C	biological_process	molecular_function	cellular_component
YPR074C	YPR074C	TKL1	hom	Verified	0.584906526262807	0.27930528504954	no	1456	0.322433367119613	1109	NA	FF|FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication	pentose-phosphate shunt	transketolase activity	cytoplasm
YMR020W	YMR020W	FMS1	hom	Verified	0.584523377282083	0.279434120958684	no	1457	0.244647052209255	839	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis	pantothenate biosynthetic process|polyamine catabolic process	polyamine oxidase activity	cytoplasm
YEL001C	YEL001C	IRC22	hom	Verified	0.583701817088483	0.279710472261534	no	1458	0.255254245127609	872	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	endoplasmic reticulum
YKL044W_p	YKL044W	YKL044W	hom	Uncharacterized	0.582689766074977	0.280051081887682	no	1459	0.261307320589018	897	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YIR023W	YIR023W	DAL81	hom	Verified	0.582320862579377	0.280175287744252	no	1460	0.390616667385269	1278	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism	nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process|urea catabolic process	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YPR045C	YPR045C	THP3	hom	Verified	0.580114540479496	0.280918689429034	no	1461	0.269285961850037	959	NA	FT	RNA PROCESSING	NUCLEUS|CHROMOSOME		Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes	mRNA splicing, via spliceosome	molecular_function	nucleus|transcriptionally active chromatin
YDL190C	YDL190C	UFD2	hom	Verified	0.580015310072427	0.280952146672123	no	1462	0.288461375406832	984	NA	FT	PROTEOLYSIS	NUCLEUS		Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3	ER-associated protein catabolic process|protein ubiquitination|ubiquitin-dependent protein catabolic process|response to stress	ubiquitin-ubiquitin ligase activity	nucleus|cytoplasm
YBR081C	YBR081C	SPT7	hom	Verified	0.579423290984734	0.281151796126476	no	1463	0.337264117925458	1139	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION	HISTONE ACETYLTRANSFERASE	Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex	conjugation with cellular fusion|histone acetylation|protein complex assembly|chromatin modification	structural molecule activity	SLIK (SAGA-like) complex|mitochondrion|SAGA complex
YGR035C_p	YGR035C	YGR035C	hom	Uncharacterized	0.579064290821694	0.281272896849525	no	1464	0.263908090893663	909	NA					Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	biological_process	molecular_function	cellular_component
YIL124W	YIL124W	AYR1	hom	Verified	0.578836272576831	0.28134982680957	no	1465	0.282414231133977	948	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM|MITOCHONDRION		NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones	phosphatidic acid biosynthetic process	acylglycerone-phosphate reductase activity	mitochondrial outer membrane|mitochondrion|integral to membrane|endoplasmic reticulum|lipid particle|cytoplasm
YDR133C_d	YDR133C	YDR133C	hom	Dubious	0.577875589532227	0.281674058445468	no	1466	0.262123944093992	899	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C	Unknown	Unknown	Unknown
YMR182W-A_p	YMR182W-A	YMR182W-A	hom	Uncharacterized	0.576729625238548	0.282061058184815	no	1467	0.249850577577465	861	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOL064C	YOL064C	MET22	hom	Verified	0.576170408897824	0.282250002162945	no	1468	0.297809300896054	1023	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway	methionine biosynthetic process|hyperosmotic salinity response|sulfate assimilation	3'(2'),5'-bisphosphate nucleotidase activity	cellular_component
YOR009W	YOR009W	TIR4	hom	Verified	0.57571893215542	0.282402588287689	no	1469	0.277908281347439	945	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock	biological_process	molecular_function	fungal-type cell wall
YGR032W	YGR032W	GSC2	hom	Verified	0.575051826679098	0.282628123309849	no	1470	0.264428140194242	932	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE|CYTOSKELETON		Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)	ascospore wall assembly|(1->3)-beta-D-glucan biosynthetic process	1,3-beta-D-glucan synthase activity	1,3-beta-D-glucan synthase complex|integral to membrane|actin cap|prospore membrane
YNL159C	YNL159C	ASI2	hom	Verified	0.574611758401402	0.282776948970478	no	1471	0.248129764868738	860	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS		Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals	ubiquitin-dependent protein catabolic process	molecular_function	nuclear inner membrane
YCL037C	YCL037C	SRO9	hom	Verified	0.574477393465548	0.282822397034844	no	1472	0.310986225955917	1088	NA	FT	TRANSLATION			Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication	cytoplasmic translation	RNA binding	polysome
YNL203C_d	YNL203C	YNL203C	hom	Dubious	0.574323717984644	0.282874381066043	no	1473	0.287804426792422	1015	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR077C	YGR077C	PEX8	hom	Verified	0.573954544060089	0.282999280822266	no	1474	0.208301314723298	709	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p	protein targeting to peroxisome|peroxisome organization	peroxisome targeting sequence binding	peroxisomal matrix|peroxisomal membrane|extrinsic to intraperoxisomal membrane
YPL156C	YPL156C	PRM4	hom	Verified	0.573464100448994	0.283165249748116	no	1475	0.260574306929351	911	NA					Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift	biological_process	molecular_function	integral to membrane
YBL089W	YBL089W	AVT5	hom	Verified	0.573411117794292	0.283183182176424	no	1476	0.312276264817663	1032	NA					Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication	transport	transporter activity	integral to membrane
YMR186W	YMR186W	HSC82	hom	Verified	0.572821712279842	0.283382708199794	no	1477	0.286018424256689	979	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	MITOCHONDRION		Cytoplasmic chaperone of the Hsp90 family; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication	protein folding|proteasome assembly|protein refolding|telomere maintenance|'de novo' protein folding|box C/D snoRNP assembly|response to stress	unfolded protein binding|ATPase activity, coupled|ATPase activity	mitochondrion|plasma membrane|cytoplasm
YPL154C	YPL154C	PEP4	hom	Verified	0.572304930551459	0.283557704997923	no	1478	0.292894314504948	997	NA	FT	MEMBRANE ORGANIZATION|PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS	MITOCHONDRION		Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates	microautophagy|proteolysis involved in cellular protein catabolic process|cellular response to starvation	peptidase activity	fungal-type vacuole lumen|mitochondrion|fungal-type vacuole
YGR159C	YGR159C	NSR1	hom	Verified	0.572228860888022	0.283583468692431	no	1479	0.292356852277214	981	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION		Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis	ribosomal small subunit assembly|rRNA processing	single-stranded DNA binding|RNA binding	mitochondrion|nucleolus|nucleus
YER097W_d	YER097W	YER097W	hom	Dubious	0.571716061978624	0.283757175521876	no	1480	0.326161198539064	1110	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR255W	YMR255W	GFD1	hom	Verified	0.569899394380034	0.284372967836307	no	1481	0.277046803197201	946	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress	mRNA export from nucleus	molecular_function	integral to membrane|nuclear pore|cytoplasm
YJR154W_p	YJR154W	YJR154W	hom	Uncharacterized	0.568521454148827	0.284840471056502	no	1482	0.289336218689184	954	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YPL030W	YPL030W	TRM44	hom	Verified	0.567615411717245	0.285148069971498	no	1483	0.269433177864226	915	NA	FT	RNA PROCESSING			tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene	tRNA methylation	tRNA (uracil) methyltransferase activity	cytoplasm
YHR189W	YHR189W	PTH1	hom	Verified	0.564888764215446	0.286074713228072	no	1484	0.283013731243018	956	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium	mitochondrial translation	aminoacyl-tRNA hydrolase activity	mitochondrion
YDL045W-A	YDL045W-A	MRP10	hom	Verified	0.563922359444142	0.286403486176292	no	1485	0.316374803128149	1081	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs	mitochondrial translation|mitochondrial respiratory chain complex assembly	structural constituent of ribosome	mitochondrial small ribosomal subunit
YPL060W	YPL060W	MFM1	hom	Verified	0.563774431380336	0.286453827438341	no	1486	0.31149505544354	1047	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p	mitochondrial magnesium ion transport	magnesium ion transmembrane transporter activity	integral to membrane|mitochondrial inner membrane
YOL053W	YOL053W	AIM39	hom	Verified	0.563364494495446	0.286593354615523	no	1487	0.254704950465111	870	NA	FT		MITOCHONDRION		Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YMR174C	YMR174C	PAI3	hom	Verified	0.563020073981484	0.286710607384615	no	1488	0.276722806557095	955	NA					Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact	vacuolar protein catabolic process	endopeptidase inhibitor activity	cytoplasm
YJR008W	YJR008W	MHO1	hom	Verified	0.562882561927156	0.286757427641756	no	1489	0.280490914864618	945	NA	FT		NUCLEUS		Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility	biological_process	molecular_function	nucleus|cytoplasm
YML004C	YML004C	GLO1	hom	Verified	0.5628152501574	0.286780347349198	no	1490	0.290184486159433	969	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress	methylglyoxal catabolic process to D-lactate|glutathione metabolic process	lactoylglutathione lyase activity	nucleus|cytoplasm
YMR009W	YMR009W	ADI1	hom	Verified	0.562264787245904	0.286967812956965	no	1491	0.272257950001958	928	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions	L-methionine salvage from methylthioadenosine	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	nucleus|cytoplasm
YAL068C	YAL068C	PAU8	hom	Verified	0.561804203121737	0.287124714044786	no	1492	0.266330581313039	913	NA	FT	TRANSCRIPTION FROM RNA POL II			Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YLR361C-A_p	YLR361C-A	YLR361C-A	hom	Uncharacterized	0.561604112702471	0.287192888848247	no	1493	0.280041353609069	963	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBL051C	YBL051C	PIN4	hom	Verified	0.56110565074146	0.287362758109152	no	1494	0.302784984580045	1036	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE			Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage	G2/M transition of mitotic cell cycle|DNA damage checkpoint	molecular_function	cytoplasm
YKL100C_p	YKL100C	YKL100C	hom	Uncharacterized	0.560922761744848	0.287425096183787	no	1495	0.261450805999355	863	NA	FT	PROTEOLYSIS			Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene	biological_process	molecular_function	integral to membrane
YCR091W	YCR091W	KIN82	hom	Verified	0.56090906545876	0.287429764847292	no	1496	0.261943716669056	932	NA	FT	MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION			Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p	phospholipid translocation|protein phosphorylation|response to pheromone	protein kinase activity	cellular_component
YHL008C_p	YHL008C	YHL008C	hom	Uncharacterized	0.560845710698067	0.287451361099644	no	1497	0.280985751402158	970	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	chloride transport|monocarboxylic acid transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|fungal-type vacuole
YOR012W_p	YOR012W	YOR012W	hom	Uncharacterized	0.56080828731802	0.287464118271978	no	1498	0.239217837511385	804	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YIL073C	YIL073C	SPO22	hom	Verified	0.560564647705922	0.287547178579577	no	1499	0.254356159790427	883	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis	regulation of synaptonemal complex assembly	molecular_function	condensed nuclear chromosome
YPL258C	YPL258C	THI21	hom	Verified	0.559785641026349	0.287812829461735	no	1500	0.2824937838392	977	NA					Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p	thiamine biosynthetic process	phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity	cellular_component
YFR053C	YFR053C	HXK1	hom	Verified	0.559662382750008	0.287854872673592	no	1501	0.30850314291181	1061	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication	mannose metabolic process|glucose import|glycolysis|fructose import|glucose metabolic process|fructose metabolic process	hexokinase activity	cytosol|mitochondrion|cytoplasm
YDR493W	YDR493W	MZM1	hom	Verified	0.556837005379025	0.288819398968476	no	1502	0.276106932435396	969	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog	mitochondrial respiratory chain complex III assembly	molecular_function	mitochondrion|mitochondrial matrix
YCR006C_d	YCR006C	YCR006C	hom	Dubious	0.556721133890112	0.288858987589259	no	1503	0.294260488049675	998	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR030W	YOR030W	DFG16	hom	Verified	0.556447078848058	0.288952631321627	no	1504	0.319911570470396	1118	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p	pseudohyphal growth|protein processing	molecular_function	integral to membrane
YHL005C_d	YHL005C	YHL005C	hom	Dubious	0.555744287476449	0.289192838147629	no	1505	0.272524744090836	951	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W	Unknown	Unknown	Unknown
YHR103W	YHR103W	SBE22	hom	Verified	0.55423412227659	0.289709314353756	no	1506	0.292964862768385	994	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	GOLGI APPARATUS		Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth	fungal-type cell wall organization	molecular_function	cytoplasm
YIL155C	YIL155C	GUT2	hom	Verified	0.553959160662528	0.289803397734968	no	1507	0.267803565783771	886	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner	NADH oxidation|replicative cell aging|glycerol metabolic process	glycerol-3-phosphate dehydrogenase activity	mitochondrion|integral to mitochondrial outer membrane
YOR038C	YOR038C	HIR2	hom	Verified	0.552557513923265	0.29028322063752	no	1508	0.283336567943297	966	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p	DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter	nucleosome binding|transcription corepressor activity|DNA binding	HIR complex|nucleus
YBR201W	YBR201W	DER1	hom	Verified	0.552015493143114	0.290468869231623	no	1509	0.294652854920484	1005	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p	ER-associated protein catabolic process	molecular_function	integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YLR332W	YLR332W	MID2	hom	Verified	0.550375306501997	0.291030991015815	no	1510	0.309188736445371	1053	NA	FT	RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p	UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|cell morphogenesis involved in conjugation|response to acid|response to osmotic stress	transmembrane signaling receptor activity	integral to plasma membrane|mating projection tip
YPL189W	YPL189W	GUP2	hom	Verified	0.549913091749406	0.291189492151136	no	1511	0.239601510974591	786	NA					Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog	glycerol transport	O-acyltransferase activity	integral to membrane|membrane
YIL039W	YIL039W	TED1	hom	Verified	0.54904921875589	0.291485836593624	no	1512	0.321458450460502	1070	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	ER to Golgi vesicle-mediated transport	molecular_function	endoplasmic reticulum
YDL076C	YDL076C	RXT3	hom	Verified	0.548687653032052	0.291609910451557	no	1513	0.301478196962771	1004	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase I promoter	molecular_function	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YPL087W	YPL087W	YDC1	hom	Verified	0.544953193479458	0.292892855022271	no	1514	0.269675688477025	925	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication	ceramide catabolic process|ceramide biosynthetic process	dihydroceramidase activity	integral to membrane|endoplasmic reticulum
YMR151W_d	YMR151W	YIM2	hom	Dubious	0.544757248243166	0.292960242760322	no	1515	0.285305284072737	956	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1	Unknown	Unknown	Unknown
YPL092W	YPL092W	SSU1	hom	Verified	0.544483570346335	0.293054375661434	no	1516	0.298228928838137	969	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein	sulfite transport	sulfite transmembrane transporter activity	integral to membrane|plasma membrane
YLR236C_d	YLR236C	YLR236C	hom	Dubious	0.544088517589195	0.293190280799991	no	1517	0.281409787080544	956	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR200W	YLR200W	YKE2	hom	Verified	0.543777682069038	0.293297234256465	no	1518	0.329791310965377	1128	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin	protein folding|tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YBR125C	YBR125C	PTC4	hom	Verified	0.541761860257542	0.293991284304511	no	1519	0.269631756772684	908	NA					Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity	protein dephosphorylation	protein serine/threonine phosphatase activity	cytoplasm
YDL121C_p	YDL121C	YDL121C	hom	Uncharacterized	0.541120691617285	0.294212198559263	no	1520	0.279372463471528	928	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein	biological_process	molecular_function	endoplasmic reticulum
YNR075W	YNR075W	COS10	hom	Verified	0.540897665967952	0.294289059881167	no	1521	0.267792846528012	918	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	endocytosis	molecular_function	nuclear envelope|integral to membrane|endoplasmic reticulum|cytoplasm
YLR090W	YLR090W	XDJ1	hom	Verified	0.540447543570269	0.294444213787549	no	1522	0.312973824555183	1059	NA	FT		NUCLEUS|MITOCHONDRION		Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	protein folding	chaperone binding	mitochondrion|integral to mitochondrial outer membrane|nucleus
YCR089W	YCR089W	FIG2	hom	Verified	0.540133027254551	0.294552647671279	no	1523	0.278137420762223	924	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating	filamentous growth of a population of unicellular organisms|cell morphogenesis involved in conjugation with cellular fusion|invasive growth in response to glucose limitation|cytogamy	molecular_function	fungal-type cell wall|mating projection
YOL060C	YOL060C	MAM3	hom	Verified	0.540098405473865	0.294564585138463	no	1524	0.282200887373506	973	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS			Protein required for normal mitochondrial morphology, has similarity to hemolysins	cellular manganese ion homeostasis|mitochondrion organization	molecular_function	fungal-type vacuole membrane|integral to membrane
YGL067W	YGL067W	NPY1	hom	Verified	0.539827870719875	0.29465787224829	no	1525	0.244785900456144	809	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member	NADH metabolic process	NAD+ diphosphatase activity	peroxisome|cytoplasm
YPR020W	YPR020W	ATP20	hom	Verified	0.536799445635637	0.295703077321338	no	1526	0.292569832676869	1016	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex	protein oligomerization|cristae formation|protein complex assembly|ATP synthesis coupled proton transport	structural molecule activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YJL073W	YJL073W	JEM1	hom	Verified	0.536119223599525	0.295938077532518	no	1527	0.302072813734995	1046	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2	karyogamy involved in conjugation with cellular fusion|ER-associated protein catabolic process|protein folding in endoplasmic reticulum	unfolded protein binding|chaperone binding	endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YNL105W_d	YNL105W	RRT16	hom	Dubious	0.535943570953921	0.295998775188255	no	1528	0.267950981694717	916	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription	Unknown	Unknown	Unknown
YLR414C	YLR414C	PUN1	hom	Verified	0.535798332751813	0.296048967295862	no	1529	0.258067741035966	849	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress	fungal-type cell wall organization|protein oligomerization	molecular_function	integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YDL223C	YDL223C	HBT1	hom	Verified	0.534451597408451	0.296514564423517	no	1530	0.325244666669907	1114	NA					Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis	cell morphogenesis involved in conjugation with cellular fusion	molecular_function	plasma membrane|mating projection
YBR150C	YBR150C	TBS1	hom	Verified	0.534314039411615	0.296562140240771	no	1531	0.278182037717197	951	NA	FT	TRANSCRIPTION FROM RNA POL II	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication	biological_process	sequence-specific DNA binding	mitochondrion|nucleus|cytoplasm
YNL304W	YNL304W	YPT11	hom	Verified	0.534176969477621	0.296609550734905	no	1532	0.305721755427966	1046	NA	FT	SIGNALING|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells	mitochondrion inheritance|endoplasmic reticulum inheritance|Golgi inheritance|Golgi localization	GTPase activity	incipient cellular bud site|endoplasmic reticulum|cellular bud neck|cellular bud tip
YKR070W_p	YKR070W	YKR070W	hom	Uncharacterized	0.532943856681393	0.297036222511419	no	1533	0.289193894659224	959	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YDR444W_p	YDR444W	YDR444W	hom	Uncharacterized	0.5321876646682	0.297298012767709	no	1534	0.299869525182003	1009	NA	FT	LIPID METABOLISM			Putative hydrolase acting on ester bonds	biological_process	molecular_function	cytoplasm
YDR440W	YDR440W	DOT1	hom	Verified	0.531992473626865	0.297365604138437	no	1535	0.301018587496746	1041	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS		Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response	meiotic recombination checkpoint|postreplication repair|recombinational repair|global genome nucleotide-excision repair|nucleotide-excision repair|DNA damage checkpoint|chromatin silencing at telomere|histone H3-K79 methylation	nucleosomal histone binding|histone methyltransferase activity (H3-K79 specific)	nucleus
YLR131C	YLR131C	ACE2	hom	Verified	0.531684517682738	0.297472258368314	no	1536	0.432007925557336	1431	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION	NUCLEUS		Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication	Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YLR199C	YLR199C	PBA1	hom	Verified	0.531634127821809	0.297489711526755	no	1537	0.264416028815271	903	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly	proteasome assembly	molecular_function	cytoplasm
YLR429W	YLR429W	CRN1	hom	Verified	0.529513097176935	0.298224780661561	no	1538	0.286774717803176	1014	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly	microtubule-based process|actin filament organization|actin cortical patch localization|Unknown|negative regulation of Arp2/3 complex-mediated actin nucleation	microtubule binding|actin filament binding|protein binding, bridging	Arp2/3 protein complex|actin cortical patch
YLR436C	YLR436C	ECM30	hom	Verified	0.528865132504031	0.298449505580626	no	1539	0.315103280777928	1081	NA	FT	CELL WALL ORG/BIOGENESIS			Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm	fungal-type cell wall organization	molecular_function	cytoplasm
YOL044W	YOL044W	PEX15	hom	Verified	0.528665056452193	0.29851891084752	no	1540	0.285506431153645	966	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly	protein import into peroxisome matrix, receptor recycling	protein anchor	integral to peroxisomal membrane
YGL126W	YGL126W	SCS3	hom	Verified	0.528379745735397	0.298617896243202	no	1541	0.306416747741705	1037	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol	phospholipid metabolic process	molecular_function	integral to membrane|endoplasmic reticulum
YLR239C	YLR239C	LIP2	hom	Verified	0.527982005616523	0.29875591267757	no	1542	0.374741170436097	1248	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups	protein lipoylation	ligase activity	mitochondrion
YCR053W	YCR053W	THR4	hom	Verified	0.526564100984287	0.299248163515446	no	1543	0.277221155444667	937	NA	FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|AMINO ACID METABOLISM	NUCLEUS		Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway	endocytosis|threonine metabolic process	threonine synthase activity	nucleus|cytoplasm
YGR162W	YGR162W	TIF4631	hom	Verified	0.525589565584478	0.299586704061027	no	1544	0.303047968686423	1066	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION	MITOCHONDRION	RIBOSOME	Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication	translational initiation|ribosomal large subunit biogenesis|stress granule assembly	translation initiation factor activity	mitochondrion|ribosome|eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YGR214W	YGR214W	RPS0A	hom	Verified	0.525465777618564	0.29962971876238	no	1545	0.300132444255119	1008	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YDR528W	YDR528W	HLR1	hom	Verified	0.524178244604739	0.300077285481268	no	1546	0.279428278672993	928	NA	FT	CELL WALL ORG/BIOGENESIS			Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A; <br>HLR1 has a paralog, LRE1, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cytoplasm
YBR141C_p	YBR141C	YBR141C	hom	Uncharacterized	0.523917108403592	0.300168097405016	no	1547	0.282953324977759	939	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleolus
YAL056W	YAL056W	GPB2	hom	Verified	0.523724394201626	0.300235123072882	no	1548	0.296488561872302	1024	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	MITOCHONDRION|PLASMA MEMBRANE		Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication	signal transduction|glucose mediated signaling pathway|pseudohyphal growth|ascospore formation|negative regulation of Ras protein signal transduction|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter	cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding	mitochondrion|plasma membrane|cytoplasm
YMR088C	YMR088C	VBA1	hom	Verified	0.523641472579409	0.300263965152258	no	1549	0.298962666714686	1008	NA					Permease of basic amino acids in the vacuolar membrane	basic amino acid transport	basic amino acid transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YPL165C	YPL165C	SET6	hom	Verified	0.521826261346718	0.300895651597925	no	1550	0.285396782440892	963	NA					SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability	biological_process	molecular_function	cellular_component
YNL332W	YNL332W	THI12	hom	Verified	0.521604702046496	0.300972794395485	no	1551	0.282690398357855	974	NA					Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13	thiamine biosynthetic process	molecular_function	cellular_component
YMR039C	YMR039C	SUB1	hom	Verified	0.521272401944048	0.301088511778535	no	1552	0.285123292553466	987	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress	termination of RNA polymerase II transcription|hyperosmotic response|RNA polymerase III transcriptional preinitiation complex assembly|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase III promoter	transcription coactivator activity	nucleus
YDR029W_d	YDR029W	YDR029W	hom	Dubious	0.520616938779301	0.301316823498141	no	1553	0.286277490158583	958	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL213W	YJL213W	YJL213W	hom	Verified	0.520549174073879	0.301340431827714	no	1554	0.290983172995704	987	NA					Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p	biological_process	molecular_function	ribosome
YMR084W_p	YMR084W	YMR084W	hom	Uncharacterized	0.519761649411746	0.301614856089345	no	1555	0.302432544196656	1020	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1	biological_process	molecular_function	cellular_component
YKL167C	YKL167C	MRP49	hom	Verified	0.519349635620934	0.30175847297681	no	1556	0.301616422706958	1017	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGR001C_p	YGR001C	YGR001C	hom	Uncharacterized	0.519276551654725	0.301783951284829	no	1557	0.274099990770172	928	NA					Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae	biological_process	methyltransferase activity	cytoplasm
YLR377C	YLR377C	FBP1	hom	Verified	0.519169448226353	0.30182129110016	no	1558	0.305099096681734	1029	NA	FT	CARBOHYDRATE METABOLISM			Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p	gluconeogenesis|reactive oxygen species metabolic process	fructose 1,6-bisphosphate 1-phosphatase activity	cytosol
YKR011C	YKR011C	YKR011C	hom	Verified	0.518429309228246	0.302079384892812	no	1559	0.294689267795502	968	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YDL057W_p	YDL057W	YDL057W	hom	Uncharacterized	0.517965289799838	0.302241243581504	no	1560	0.274740825737917	957	NA					Putative protein of unknown function; YDL057W is not an essential gene	biological_process	molecular_function	cellular_component
YMR193W	YMR193W	MRPL24	hom	Verified	0.517883703598618	0.302269706402791	no	1561	0.281562946995716	964	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YMR150C	YMR150C	IMP1	hom	Verified	0.517574261196219	0.302377671909113	no	1562	0.291179527872837	976	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	protein processing involved in protein targeting to mitochondrion	endopeptidase activity	mitochondrion|mitochondrial inner membrane peptidase complex
YGR199W	YGR199W	PMT6	hom	Verified	0.516394032096909	0.302789616548911	no	1563	0.302459495596241	1036	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases	protein O-linked glycosylation|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane
YPR071W_p	YPR071W	YPR071W	hom	Uncharacterized	0.516382175652494	0.302793756171751	no	1564	0.317354265291383	1088	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C	biological_process	molecular_function	integral to membrane
YPR134W	YPR134W	MSS18	hom	Verified	0.516319825944399	0.302815525701607	no	1565	0.309211642686911	1072	NA	FT	RNA PROCESSING	MITOCHONDRION		Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions	Group I intron splicing	molecular_function	mitochondrion
YGR037C	YGR037C	ACB1	hom	Verified	0.516070554160401	0.302902566463026	no	1566	0.367456789795504	1236	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	NUCLEUS		Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress	long-chain fatty acid transport|chronological cell aging|fatty acid metabolic process	long-chain fatty acid transporter activity|fatty-acyl-CoA binding	extracellular region|nucleus|cytoplasm
YJL152W_d	YJL152W	YJL152W	hom	Dubious	0.515310803358148	0.303167925429228	no	1567	0.232704486565358	779	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR022C_p	YPR022C	YPR022C	hom	Uncharacterized	0.515246590215973	0.303190357985204	no	1568	0.313461903946962	1049	NA	FT		NUCLEUS		Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	sequence-specific DNA binding	nucleus|cytoplasm
YJR005W	YJR005W	APL1	hom	Verified	0.515059963958329	0.303255559194159	no	1569	0.297043837872505	1034	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YNL175C	YNL175C	NOP13	hom	Verified	0.514002194144439	0.303625228315315	no	1570	0.319091724586431	1074	NA	FT		NUCLEUS		Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress	biological_process	RNA binding	nucleolus|preribosome
YJL092W	YJL092W	SRS2	hom	Verified	0.513847897724615	0.303679168597332	no	1571	0.311614405231735	1055	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability	DNA repair|double-strand break repair via nonhomologous end joining|DNA duplex unwinding	DNA helicase activity	nucleus
YJL077C	YJL077C	ICS3	hom	Verified	0.513043303136	0.30396051503622	no	1572	0.308385216324544	1073	NA					Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2	biological_process	molecular_function	cellular_component
YJL139C	YJL139C	YUR1	hom	Verified	0.512960333679025	0.303989533972311	no	1573	0.307475752476673	1049	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication	cell wall mannoprotein biosynthetic process|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YPL106C	YPL106C	SSE1	hom	Verified	0.512877154727665	0.304018627419749	no	1574	0.324410182203275	1080	NA					ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication	protein folding|protein refolding	peptide binding|adenyl-nucleotide exchange factor activity|ATP binding	polysome|cytoplasm
YFR009W	YFR009W	GCN20	hom	Verified	0.512540612182161	0.304136352354302	no	1575	0.338961067919591	1155	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA	regulation of translational elongation	ATPase activity	cytosol|cytosolic ribosome
YBR013C_p	YBR013C	YBR013C	hom	Uncharacterized	0.512434128718287	0.304173605244027	no	1576	0.317131845214445	1096	NA					Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein	biological_process	molecular_function	cellular_component
YBR063C_p	YBR063C	YBR063C	hom	Uncharacterized	0.510945899908433	0.304694469799125	no	1577	0.292474317520257	1014	NA					Putative protein of unknown function; YBR063C is not an essential gene	biological_process	molecular_function	cellular_component
YOR062C_p	YOR062C	YOR062C	hom	Uncharacterized	0.510941697943232	0.304695941004437	no	1578	0.284556275138151	993	NA	FT		NUCLEUS		Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YFL049W	YFL049W	SWP82	hom	Verified	0.509198785576571	0.30530644712216	no	1579	0.292867031706729	981	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	RSC COMPLEX	Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex|nucleus
YJL216C	YJL216C	IMA5	hom	Verified	0.509119843764521	0.305334111646634	no	1580	0.319589500970567	1090	NA	FT	CARBOHYDRATE METABOLISM			Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose	disaccharide catabolic process	oligo-1,6-glucosidase activity	cellular_component
YLR225C_p	YLR225C	YLR225C	hom	Uncharacterized	0.507680813215079	0.305838603096597	no	1581	0.311816095671054	1073	NA	FT	RESPONSE TO OXIDATIVE STRESS			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene	biological_process	molecular_function	cytoplasm
YJL133W	YJL133W	MRS3	hom	Verified	0.506671956907249	0.306192505115567	no	1582	0.287853922849085	985	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication	mitochondrial iron ion transport|RNA splicing	iron ion transmembrane transporter activity	mitochondrion|integral to membrane
YER178W	YER178W	PDA1	hom	Verified	0.505680464223685	0.306540492360647	no	1583	0.323435217463427	1109	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose	acetyl-CoA biosynthetic process from pyruvate	pyruvate dehydrogenase (acetyl-transferring) activity	mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YEL005C	YEL005C	VAB2	hom	Verified	0.505560614434013	0.306582568238649	no	1584	0.305432752804788	1030	NA					Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter	biological_process	molecular_function	cytoplasm
YOL031C	YOL031C	SIL1	hom	Verified	0.505408733923654	0.306635892861079	no	1585	0.295565304098422	1018	NA	FT	PROTEIN LOCALIZATION	ENDOPLASMIC RETICULUM		Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein	SRP-dependent cotranslational protein targeting to membrane, translocation	adenyl-nucleotide exchange factor activity	endoplasmic reticulum
YCL069W	YCL069W	VBA3	hom	Verified	0.505067701970966	0.306755642690346	no	1586	0.308173731074496	1046	NA					Permease of basic amino acids in the vacuolar membrane	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YPR028W	YPR028W	YOP1	hom	Verified	0.50485680664265	0.306829706718345	no	1587	0.308910443517404	1050	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress	vesicle-mediated transport|endoplasmic reticulum organization|endoplasmic reticulum inheritance|nuclear pore complex assembly	protein binding	integral to membrane|endoplasmic reticulum|endoplasmic reticulum tubular network
YDR387C_p	YDR387C	YDR387C	hom	Uncharacterized	0.504385121977409	0.306995385519521	no	1588	0.285612306331338	965	NA					Putative transporter, member of the sugar porter family; YDR387C is not an essential gene	transport|transmembrane transport	substrate-specific transmembrane transporter activity	integral to membrane|membrane
YLR357W	YLR357W	RSC2	hom	Verified	0.504289156305653	0.307029098199706	no	1589	0.315788420237826	1057	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance	ATP-dependent chromatin remodeling|chromosome segregation|nucleosome disassembly|plasmid maintenance|sister chromatid cohesion|double-strand break repair via nonhomologous end joining|transcription elongation from RNA polymerase II promoter|double-strand break repair via homologous recombination	DNA translocase activity	RSC complex
YGL157W	YGL157W	ARI1	hom	Verified	0.503824887303038	0.307192218644121	no	1590	0.300042875132631	1000	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily	biological_process	oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YPR077C_d	YPR077C	YPR077C	hom	Dubious	0.501939493244101	0.307855041809258	no	1591	0.31236105154837	1067	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1	Unknown	Unknown	Unknown
YOR306C	YOR306C	MCH5	hom	Verified	0.501844379576934	0.30788849631176	no	1592	0.295317502309247	986	NA	FT		PLASMA MEMBRANE		Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport	riboflavin transport	monocarboxylic acid transmembrane transporter activity|riboflavin transporter activity	integral to membrane|plasma membrane
YDL130W-A	YDL130W-A	STF1	hom	Verified	0.500015278127259	0.308532159847666	no	1593	0.322686616638102	1119	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress	negative regulation of ATPase activity	molecular_function	mitochondrion|mitochondrial proton-transporting ATP synthase complex
YML117W	YML117W	NAB6	hom	Verified	0.499934885044629	0.3085604638172	no	1594	0.305702901756376	999	NA					Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP	biological_process	molecular_function	cytoplasm
YBL055C	YBL055C	YBL055C	hom	Verified	0.499461125657928	0.308727283249097	no	1595	0.292180395865634	971	NA	FT	RESPONSE TO OXIDATIVE STRESS			3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases	cellular response to oxidative stress|apoptotic DNA fragmentation	3'-5'-exodeoxyribonuclease activity|endonuclease activity	cytoplasm
YMR124W_p	YMR124W	YMR124W	hom	Uncharacterized	0.49904768113937	0.308872896961811	no	1596	0.296617028370006	1009	NA					Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization	biological_process	molecular_function	cytoplasm
YMR256C	YMR256C	COX7	hom	Verified	0.4980424936062	0.309227045787502	no	1597	0.330998610096355	1116	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YPR037C	YPR037C	ERV2	hom	Verified	0.497401552455816	0.309452955516767	no	1598	0.306726019041768	1041	NA	FT	OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER	protein thiol-disulfide exchange	thiol oxidase activity	integral to endoplasmic reticulum membrane
YNL278W	YNL278W	CAF120	hom	Verified	0.496954675489175	0.309610506913948	no	1599	0.297775296129033	990	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|SITE OF POLARIZED GROWTH		Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter	molecular_function	CCR4-NOT complex
YBR094W	YBR094W	PBY1	hom	Verified	0.496562355776332	0.309748852396294	no	1600	0.295600970563569	989	NA					Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|biological_process	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YPL015C	YPL015C	HST2	hom	Verified	0.496545224556454	0.309754894070478	no	1601	0.323616581084658	1068	NA	FT	GENE SILENCING	NUCLEUS		Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export	negative regulation of chromatin silencing at telomere|chronological cell aging|chromatin silencing at rDNA|negative regulation of mitotic recombination	NAD-dependent histone deacetylase activity	cytoplasm
YPL245W_p	YPL245W	YPL245W	hom	Uncharacterized	0.496482664723754	0.309776957508273	no	1602	0.297811958083137	1006	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YNL010W_p	YNL010W	YNL010W	hom	Uncharacterized	0.496153301883824	0.309893127631132	no	1603	0.333887023100453	1140	NA	FT		NUCLEUS		Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation	biological_process	molecular_function	nucleus|cytoplasm
YJL101C	YJL101C	GSH1	hom	Verified	0.495322421017698	0.310186273360134	no	1604	0.296962386818148	986	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS			Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress	response to cadmium ion|response to hydrogen peroxide|glutathione biosynthetic process	glutamate-cysteine ligase activity	intracellular
YMR110C	YMR110C	HFD1	hom	Verified	0.494878520923201	0.31034293663361	no	1605	0.29314036669401	979	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder	cellular aldehyde metabolic process	3-chloroallyl aldehyde dehydrogenase activity	mitochondrial outer membrane|endosome|mitochondrion|lipid particle|integral to mitochondrial outer membrane
YLR138W	YLR138W	NHA1	hom	Verified	0.494469744299522	0.310487234411623	no	1606	0.300194946074412	1030	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH	cellular potassium ion homeostasis|cellular monovalent inorganic cation homeostasis|response to osmotic stress	cation:cation antiporter activity|sodium:hydrogen antiporter activity	membrane raft|integral to membrane|plasma membrane
YLR084C	YLR084C	RAX2	hom	Verified	0.494377074438714	0.310519950845157	no	1607	0.342491713337805	1150	NA	FT	CELL CYCLE|CELL DIVISION	MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p	cellular bud site selection	molecular_function	mitochondrion|cellular bud scar|cellular bud neck|membrane
YER119C-A_d	YER119C-A	YER119C-A	hom	Dubious	0.494167504613169	0.310593943505025	no	1608	0.338670428073695	1168	NA	FF				Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2	Unknown	Unknown	Unknown
YIL128W	YIL128W	MET18	hom	Verified	0.493812885561073	0.310719166039091	no	1609	0.472659393293382	1588	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE	NUCLEUS		Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19	methionine metabolic process|nucleotide-excision repair|transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YGR266W	YGR266W	YGR266W	hom	Verified	0.491849753170309	0.311412780743678	no	1610	0.300452285803995	1035	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|plasma membrane
YOR286W	YOR286W	RDL2	hom	Verified	0.491275131955988	0.311615932995095	no	1611	0.303679131291965	999	NA	FT		MITOCHONDRION		Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	thiosulfate sulfurtransferase activity	mitochondrion
YOR059C	YOR059C	YOR059C	hom	Verified	0.4911070707777	0.311675360382437	no	1612	0.29652655985377	1054	NA	FT	LIPID METABOLISM			Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	lipid particle
YGL181W	YGL181W	GTS1	hom	Verified	0.490632432742624	0.311843221571988	no	1613	0.317647307138935	1054	NA	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	NUCLEUS|CYTOSKELETON		Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations	endocytosis|ultradian rhythm|regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylinositol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	ARF GTPase activator activity|repressing transcription factor binding|transcription factor binding transcription factor activity	nucleus|cytoplasm|actin cortical patch
YER117W	YER117W	RPL23B	hom	Verified	0.490579925298254	0.311861793834638	no	1614	0.309314456455354	1050	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDL133C-A	YDL133C-A	RPL41B	hom	Verified	0.489445545020928	0.312263149088663	no	1615	0.300441607475767	1051	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOL052C-A	YOL052C-A	DDR2	hom	Verified	0.488604213565405	0.312560964682138	no	1616	0.312496379960237	1047	NA					Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication	response to stress	molecular_function	fungal-type vacuole|cytoplasm
YJR014W	YJR014W	TMA22	hom	Verified	0.488406954150234	0.312630808550826	no	1617	0.258559821185202	853	NA	FT	TRANSLATION		RIBOSOME	Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress	biological_process	RNA binding	ribosome|cytoplasm
YOR273C	YOR273C	TPO4	hom	Verified	0.487595366566342	0.312918239078785	no	1618	0.404770985600126	1359	NA	FF|FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane	spermidine transport|spermine transport	spermidine transmembrane transporter activity|spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YML083C	YML083C	YML083C	hom	Verified	0.487498406116237	0.312952586043379	no	1619	0.295895903991295	1040	NA					Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions	biological_process	molecular_function	cellular_component
YOL145C	YOL145C	CTR9	hom	Verified	0.486940741496326	0.313150162917065	no	1620	0.368547802124237	1233	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats	transcription elongation from RNA polymerase I promoter|mRNA 3'-end processing|regulation of chromatin silencing at telomere|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|regulation of transcription initiation from RNA polymerase II promoter|snoRNA 3'-end processing|Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	RNA polymerase II core binding|triplex DNA binding|RNA polymerase II transcription factor binding transcription factor activity	transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YNL034W_p	YNL034W	YNL034W	hom	Uncharacterized	0.486824468903056	0.313191364287016	no	1621	0.310025067758116	1036	NA					Putative protein of unknown function; YNL034W is not an essential gene	biological_process	molecular_function	cellular_component
YIL121W	YIL121W	QDR2	hom	Verified	0.486728818541535	0.313225259886308	no	1622	0.297126138571096	1003	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper	drug transmembrane transport|potassium ion import	drug transmembrane transporter activity	integral to membrane|integral to plasma membrane
YDR058C	YDR058C	TGL2	hom	Verified	0.486442332768662	0.313326791232422	no	1623	0.319824577682789	1107	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli	triglyceride catabolic process	triglyceride lipase activity	mitochondrion
YJL059W	YJL059W	YHC3	hom	Verified	0.485927921007178	0.313509135687142	no	1624	0.304216109097044	1020	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)	basic amino acid transport|regulation of intracellular pH|arginine transport	molecular_function	integral to membrane|fungal-type vacuole
YBR204C	YBR204C	LDH1	hom	Verified	0.485061956259119	0.313816198698823	no	1625	0.31167390013532	1032	NA	FT	LIPID METABOLISM			Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)	lipid homeostasis	hydrolase activity, acting on ester bonds|serine hydrolase activity|triglyceride lipase activity	lipid particle
YLR104W_p	YLR104W	LCL2	hom	Uncharacterized	0.483791916699435	0.31426677616366	no	1626	0.316336960510136	1035	NA	FT	PROTEOLYSIS			Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)	ER-associated protein catabolic process	molecular_function	cellular_component
YLR178C	YLR178C	TFS1	hom	Verified	0.48348381691597	0.314376123826475	no	1627	0.286033870874494	959	NA	FT	SIGNALING|PROTEOLYSIS			Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress	regulation of Ras protein signal transduction|regulation of proteolysis	lipid binding|peptidase inhibitor activity|phospholipid binding	fungal-type vacuole lumen|fungal-type vacuole membrane|cytoplasm
YNL303W_d	YNL303W	YNL303W	hom	Dubious	0.483362851895552	0.314419059963341	no	1628	0.302972228296138	1036	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR252W_d	YLR252W	YLR252W	hom	Dubious	0.483348075996557	0.314424304792251	no	1629	0.32790084014258	1103	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism	Unknown	Unknown	Unknown
YNR031C	YNR031C	SSK2	hom	Verified	0.483214614862804	0.314471679634773	no	1630	0.314498472525165	1087	NA	FT	SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress	MAPK cascade involved in osmosensory signaling pathway|protein autophosphorylation|protein phosphorylation|response to osmotic stress|actin cytoskeleton organization|osmosensory signaling pathway via two-component system	MAP kinase kinase kinase activity	cytosol|cellular bud neck|cellular bud tip
YKR092C	YKR092C	SRP40	hom	Verified	0.482954054958932	0.314564179669444	no	1631	0.312865935049975	1065	NA	FT		NUCLEUS		Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140	nucleocytoplasmic transport	molecular_function	nucleolus
YPL157W	YPL157W	TGS1	hom	Verified	0.481460787801236	0.315094521158794	no	1632	0.294988167211011	1007	NA	FT	CELL CYCLE|RNA PROCESSING	NUCLEUS		Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs	meiosis|RNA methylation|nucleologenesis|7-methylguanosine cap hypermethylation|regulation of telomere maintenance via telomerase	RNA methyltransferase activity	nucleolus
YPR148C	YPR148C	YPR148C	hom	Verified	0.480521121240848	0.315428444142504	no	1633	0.300462874511248	1026	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	ribosome|cytoplasm
YAL030W	YAL030W	SNC1	hom	Verified	0.480518107497404	0.315429515358976	no	1634	0.302037987820195	1034	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication	endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion	SNAP receptor activity	SNARE complex|trans-Golgi network|endosome|transport vesicle membrane|plasma membrane|cellular bud neck
YNL209W	YNL209W	SSB2	hom	Verified	0.480331280292674	0.315495924962221	no	1635	0.258664308144931	895	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS			Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication	cellular response to glucose starvation|cytoplasmic translation|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity|'de novo' cotranslational protein folding	unfolded protein binding|ATPase activity	plasma membrane|polysome|cytoplasm
YGR285C	YGR285C	ZUO1	hom	Verified	0.480137518897018	0.315564805688839	no	1636	0.310976769137417	1066	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS|MITOCHONDRION	RIBOSOME	Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p	protein folding|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity	unfolded protein binding	mitochondrion|ribosome|nucleolus|polysome|cytoplasm
YOR334W	YOR334W	MRS2	hom	Verified	0.480012219225635	0.315609352196777	no	1637	0.304378801324351	1007	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns	mitochondrial magnesium ion transport	magnesium ion transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YOL100W	YOL100W	PKH2	hom	Verified	0.479859149349053	0.315663775196978	no	1638	0.308274762944609	1029	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p	regulation of nuclear-transcribed mRNA poly(A) tail shortening|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly	protein kinase activity	cell cortex|eisosome|nucleus
YNL315C	YNL315C	ATP11	hom	Verified	0.478674029423543	0.316085272104796	no	1639	0.321260885165686	1086	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase	mitochondrion organization|mitochondrial proton-transporting ATP synthase complex assembly	unfolded protein binding	mitochondrion|mitochondrial matrix
YOR040W	YOR040W	GLO4	hom	Verified	0.477958717916634	0.316339793855172	no	1640	0.301573059448567	1005	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate	cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate	hydroxyacylglutathione hydrolase activity	mitochondrion|mitochondrial matrix
YLR404W	YLR404W	FLD1	hom	Verified	0.477871604384158	0.316370796491845	no	1641	0.318049602664381	1055	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy	lipid particle organization	molecular_function	integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum
YPL227C	YPL227C	ALG5	hom	Verified	0.477831871589274	0.316384937334315	no	1642	0.322229894870238	1099	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum	protein N-linked glycosylation	dolichyl-phosphate beta-glucosyltransferase activity	endoplasmic reticulum membrane
YBL085W	YBL085W	BOI1	hom	Verified	0.477316101193187	0.316568523605485	no	1643	0.315449554217664	1033	NA	FT	SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH		Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication	cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction	phospholipid binding	site of polarized growth|cellular bud|mating projection tip|cellular bud neck
YDR209C_d	YDR209C	YDR209C	hom	Dubious	0.477154264032665	0.316626138170693	no	1644	0.304765590783471	1048	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.	Unknown	Unknown	Unknown
YMR129W	YMR129W	POM152	hom	Verified	0.477096566121424	0.31664667989415	no	1645	0.264216461819404	898	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	NUCLEAR PORE	Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210	nucleocytoplasmic transport|nuclear pore organization|protein import into nucleus|spindle pole body duplication associated with nuclear envelope	protein anchor|structural constituent of nuclear pore	mitochondrion|integral to membrane|nuclear pore transmembrane ring|nuclear envelope lumen|nuclear pore
YDL013W	YDL013W	SLX5	hom	Verified	0.476712933274288	0.316783275989186	no	1646	0.373210621802437	1249	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers	protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination	SUMO binding|ubiquitin-protein ligase activity	ubiquitin ligase complex|nucleus
YEL041W	YEL041W	YEF1	hom	Verified	0.475165915899335	0.317334359468961	no	1647	0.338995146240311	1112	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication	NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	cellular_component
YOL014W_p	YOL014W	YOL014W	hom	Uncharacterized	0.47471331572252	0.317495662820743	no	1648	0.344009734387216	1177	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOL154W	YOL154W	ZPS1	hom	Verified	0.474669474986667	0.317511289176086	no	1649	0.294887331348274	979	NA					Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH	biological_process	molecular_function	fungal-type cell wall|fungal-type vacuole
YOL063C	YOL063C	CRT10	hom	Verified	0.474456478463344	0.317587213135018	no	1650	0.306152324484325	1046	NA	FT	TRANSCRIPTION FROM RNA POL II			Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat	regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YLR150W	YLR150W	STM1	hom	Verified	0.47344703195936	0.317947141038937	no	1651	0.308248779145324	1041	NA	FT	SIGNALING|TRANSLATION	NUCLEUS	RIBOSOME	Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery	translational elongation|TOR signaling cascade|regulation of translational initiation in response to stress|telomere maintenance|anti-apoptosis	triplex DNA binding|DNA binding|telomeric DNA binding	cytosolic ribosome|polysome|cytoplasm
YDR380W	YDR380W	ARO10	hom	Verified	0.47296849747779	0.318117827264923	no	1652	0.304204407277942	1032	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway	L-phenylalanine catabolic process|methionine catabolic process to 3-methylthiopropanol|tryptophan catabolic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway|leucine catabolic process	pyruvate decarboxylase activity|carboxy-lyase activity|phenylpyruvate decarboxylase activity	cytoplasm
YBR255W	YBR255W	MTC4	hom	Verified	0.472915829907156	0.31813661537505	no	1653	0.336844667508324	1119	NA					Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1	biological_process	molecular_function	cytoplasm
YIL116W	YIL116W	HIS5	hom	Verified	0.471951250295594	0.318480792726999	no	1654	0.319919895915649	1097	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts	histidine biosynthetic process	histidinol-phosphate transaminase activity	intracellular
YER007W	YER007W	PAC2	hom	Verified	0.471115693025184	0.318779059539141	no	1655	0.320059831711607	1085	NA	FT		CYTOSKELETON		Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl	protein folding|tubulin complex assembly|tubulin complex biogenesis	alpha-tubulin binding	cellular_component
YKR064W	YKR064W	OAF3	hom	Verified	0.470949141030504	0.318838527234977	no	1656	0.331154882040105	1116	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|cellular response to oleic acid	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity	mitochondrion|nucleus|cytoplasm
YBL061C	YBL061C	SKT5	hom	Verified	0.46999918804484	0.319177798833557	no	1657	0.327786807761922	1109	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication	fungal-type cell wall chitin biosynthetic process|response to osmotic stress|cytokinesis	enzyme activator activity	incipient cellular bud site|cellular bud neck septin ring|cellular bud neck
YDR024W_d	YDR024W	FYV1	hom	Dubious	0.469809103336649	0.319245704964075	no	1658	0.334816619672792	1145	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin	Unknown	Unknown	Unknown
YJL208C	YJL208C	NUC1	hom	Verified	0.468735098333872	0.319629497912418	no	1659	0.322091546504104	1077	NA	FT		NUCLEUS|MITOCHONDRION		Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy	DNA catabolic process|RNA catabolic process|apoptotic process|DNA recombination	ribonuclease activity|endodeoxyribonuclease activity|exodeoxyribonuclease activity	mitochondrion|mitochondrial inner membrane|nucleus
YJL150W_d	YJL150W	YJL150W	hom	Dubious	0.467655164514659	0.320015604369906	no	1660	0.294902698610442	1008	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR005C	YOR005C	DNL4	hom	Verified	0.466613888074874	0.32038807443937	no	1661	0.30192012325458	1050	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	NUCLEUS|CHROMOSOME		DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth	double-strand break repair via nonhomologous end joining|replicative cell aging	DNA ligase (ATP) activity	DNA ligase IV complex|nuclear chromatin
YDR442W_d	YDR442W	YDR442W	hom	Dubious	0.465898245584048	0.320644168504253	no	1662	0.346303988479514	1187	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR046C	YDR046C	BAP3	hom	Verified	0.465820441559173	0.320672015975579	no	1663	0.299300426466921	1021	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YDR375C	YDR375C	BCS1	hom	Verified	0.462725001734007	0.321780747485409	no	1664	0.341038473865866	1154	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases	protein insertion into mitochondrial membrane from inner side|chaperone-mediated protein complex assembly|mitochondrial respiratory chain complex III assembly	protein transmembrane transporter activity|ATPase activity	mitochondrion|mitochondrial inner membrane
YOL132W	YOL132W	GAS4	hom	Verified	0.461697313444908	0.322149198965546	no	1665	0.311297814139943	1055	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall	ascospore wall assembly	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane
YOR061W	YOR061W	CKA2	hom	Verified	0.461533444635607	0.322207966128823	no	1666	0.337863800782403	1156	NA	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching	regulation of transcription from RNA polymerase I promoter|chronological cell aging|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase activity	protein kinase CK2 complex|UTP-C complex
YGR279C	YGR279C	SCW4	hom	Verified	0.46124892032493	0.322310013716767	no	1667	0.329288308758129	1099	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating	conjugation with cellular fusion	glucosidase activity	extracellular region|fungal-type cell wall
YOR165W	YOR165W	SEY1	hom	Verified	0.460319460064934	0.322643467560291	no	1668	0.329796331034812	1125	NA	FT	MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3	cellular membrane organization|endoplasmic reticulum organization|endoplasmic reticulum membrane fusion|endoplasmic reticulum inheritance	GTPase activity	integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum|cytoplasm
YMR201C	YMR201C	RAD14	hom	Verified	0.459488243987447	0.322941796126306	no	1669	0.329131600460197	1106	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein	nucleotide-excision repair, DNA damage recognition	damaged DNA binding|zinc ion binding	nucleotide-excision repair factor 1 complex|nucleus
YOR047C	YOR047C	STD1	hom	Verified	0.458948186054633	0.323135687328729	no	1670	0.332448139169164	1130	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM	NUCLEUS|PLASMA MEMBRANE		Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]	response to salt stress|signal transduction|nicotinamide riboside biosynthetic process|glucose metabolic process|nicotinic acid riboside biosynthetic process|regulation of transcription from RNA polymerase II promoter	protein kinase activator activity	plasma membrane|nucleus
YHR124W	YHR124W	NDT80	hom	Verified	0.458815694575202	0.323183261666139	no	1671	0.312144053822556	1095	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CHROMOSOME		Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)	meiosis|transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nuclear chromosome
YAL056C-A_d	YAL056C-A	YAL056C-A	hom	Dubious	0.458625364939435	0.323251609283106	no	1672	0.342415841242632	1146	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL025C_p	YEL025C	YEL025C	hom	Uncharacterized	0.458321743815063	0.323360652368879	no	1673	0.291251474760403	985	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YMR214W	YMR214W	SCJ1	hom	Verified	0.457886408070191	0.323517026177344	no	1674	0.332957264733104	1145	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOPLASMIC RETICULUM		One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins	ER-associated protein catabolic process|protein folding in endoplasmic reticulum|response to unfolded protein	chaperone binding	endoplasmic reticulum lumen
YOR081C	YOR081C	TGL5	hom	Verified	0.457299801567509	0.323727786161998	no	1675	0.309351724759263	1035	NA	FT	LIPID METABOLISM			Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate	triglyceride mobilization	lysophosphatidic acid acyltransferase activity|triglyceride lipase activity	lipid particle
YOL048C	YOL048C	RRT8	hom	Verified	0.45680846292735	0.323904361177631	no	1676	0.317486944109139	1053	NA					Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|lipid particle
YFR022W	YFR022W	ROG3	hom	Verified	0.456255943772976	0.32410297030949	no	1677	0.300345870478281	1016	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; ROG3 has a paralog, ROD1, that arose from the whole genome duplication	ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	cellular_component
YDL149W	YDL149W	ATG9	hom	Verified	0.455562520129069	0.324352299972392	no	1678	0.310195207683028	1002	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|MITOCHONDRION		Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS	piecemeal microautophagy of nucleus|mitochondrion degradation|protein homooligomerization|CVT pathway|autophagic vacuole assembly	molecular_function	mitochondrion|integral to membrane|pre-autophagosomal structure
YIL160C	YIL160C	POT1	hom	Verified	0.455195573539957	0.324484272361583	no	1679	0.314285790669002	1062	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids	fatty acid beta-oxidation	mRNA binding|acetyl-CoA C-acyltransferase activity	peroxisomal matrix|peroxisome
YOR331C_d	YOR331C	YOR331C	hom	Dubious	0.454467932510922	0.324746033740723	no	1680	0.379566615428874	1242	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W	Unknown	Unknown	Unknown
YLR415C_p	YLR415C	YLR415C	hom	Uncharacterized	0.453776010974064	0.324995025706875	no	1681	0.326370140931536	1110	NA	FT		MITOCHONDRION		Putative protein of unknown function; YLR415C is not an essential gene	biological_process	molecular_function	cellular_component
YPL166W	YPL166W	ATG29	hom	Verified	0.453607627445513	0.325055631326267	no	1682	0.320805611487373	1087	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS			Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy	molecular_function	pre-autophagosomal structure|cytoplasm
YJL132W_p	YJL132W	YJL132W	hom	Uncharacterized	0.452289047341715	0.325530382617128	no	1683	0.327561240554622	1065	NA					Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene	biological_process	molecular_function	membrane
YLR254C	YLR254C	NDL1	hom	Verified	0.451678611931029	0.325750264224649	no	1684	0.321055681845161	1080	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CYTOSKELETON		Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends	nuclear migration along microtubule	microtubule plus-end binding	cytoplasmic microtubule|nucleus|cytoplasm
YIL173W	YIL173W	VTH1	hom	Verified	0.450577702360597	0.326146970092396	no	1685	0.306506175561319	1018	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting	Golgi to vacuole transport	signal sequence binding	endosome|integral to membrane
YER115C	YER115C	SPR6	hom	Verified	0.450266897238789	0.326259002416452	no	1686	0.333854768856887	1106	NA	FT	CELL CYCLE			Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation	ascospore formation	molecular_function	cellular_component
YHL021C	YHL021C	AIM17	hom	Verified	0.449791300217872	0.326430465719169	no	1687	0.319615247006947	1046	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YIL056W	YIL056W	VHR1	hom	Verified	0.449691704396446	0.326466376874015	no	1688	0.299536954293009	1020	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter in response to biotin starvation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YBR163W	YBR163W	EXO5	hom	Verified	0.448200374484826	0.327004296243788	no	1689	0.322986881689244	1119	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2	mitochondrial genome maintenance	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity	mitochondrion
YBL091C	YBL091C	MAP2	hom	Verified	0.447637743159526	0.32720732960138	no	1690	0.328516522011475	1109	NA	FT	PROTEOLYSIS			Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p	protein initiator methionine removal involved in protein maturation	metalloaminopeptidase activity	cytoplasm
YHR146W	YHR146W	CRP1	hom	Verified	0.447540806514314	0.327242315707335	no	1691	0.347383233975301	1161	NA	FT		NUCLEUS		Protein that binds to cruciform DNA structures	biological_process	DNA binding	nucleus
YDR316W	YDR316W	OMS1	hom	Verified	0.44287187237416	0.328929206735295	no	1692	0.348606267247448	1151	NA	FT		MITOCHONDRION		Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations	biological_process	S-adenosylmethionine-dependent methyltransferase activity	mitochondrial envelope|mitochondrion
YLR437C	YLR437C	DIF1	hom	Verified	0.442778587466997	0.328962946351514	no	1693	0.313525309905864	1060	NA	FT		NUCLEUS		Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein	biological_process	molecular_function	cytoplasm
YKL046C	YKL046C	DCW1	hom	Verified	0.442172005578896	0.32918237102429	no	1694	0.292697574519456	1014	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p	fungal-type cell wall biogenesis|budding cell bud growth	mannosidase activity	anchored to plasma membrane
YDR530C	YDR530C	APA2	hom	Verified	0.441535806313566	0.329412572714971	no	1695	0.290046781965156	972	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication	nucleoside catabolic process	bis(5'-nucleosyl)-tetraphosphatase activity	nucleus|cytoplasm
YLR267W_p	YLR267W	BOP2	hom	Uncharacterized	0.440964824337277	0.329619231319746	no	1696	0.28322232948098	934	NA					Protein of unknown function	biological_process	molecular_function	cellular_component
YKR032W_d	YKR032W	YKR032W	hom	Dubious	0.439565619979438	0.330125872846825	no	1697	0.316969334730914	1083	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR184W	YPR184W	GDB1	hom	Verified	0.439131809256469	0.330283015832982	no	1698	0.33615226408202	1150	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress	glycogen catabolic process	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity	mitochondrion|cytoplasm
YLR266C	YLR266C	PDR8	hom	Verified	0.438988590749265	0.330334901678292	no	1699	0.315312383388149	1060	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YMR230W-A_p	YMR230W-A	YMR230W-A	hom	Uncharacterized	0.438956218242091	0.330346630187934	no	1700	0.328242072964474	1116	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL046W_p	YNL046W	YNL046W	hom	Uncharacterized	0.438344007003654	0.330568464747603	no	1701	0.317708270840154	1058	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	biological_process	molecular_function	endoplasmic reticulum
YJL064W_d	YJL064W	YJL064W	hom	Dubious	0.437946157646178	0.33071265726596	no	1702	0.323453593238549	1088	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1	Unknown	Unknown	Unknown
YHR136C	YHR136C	SPL2	hom	Verified	0.436376378040321	0.331281837367377	no	1703	0.348090659184255	1144	NA					Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm	response to temperature stimulus	enzyme inhibitor activity	cytoplasm
YJL136W-A_p	YJL136W-A	YJL136W-A	hom	Uncharacterized	0.435185814998323	0.331713778994042	no	1704	0.308243299308806	1009	NA					Putative protein of unknown function; identified by SAGE	biological_process	molecular_function	cellular_component
YNL098C	YNL098C	RAS2	hom	Verified	0.435028692914358	0.331770800324294	no	1705	0.381382677660713	1245	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS	PLASMA MEMBRANE		GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes	pseudohyphal growth|ascospore formation|activation of adenylate cyclase activity|regulation of protein localization|replicative cell aging|positive regulation of transcription by galactose|Ras protein signal transduction	GTP binding|GTPase activity	plasma membrane
YML048W	YML048W	GSF2	hom	Verified	0.434271309127194	0.332045717877185	no	1706	0.354584309728796	1203	NA	FF|FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression	protein folding|protein localization to cell surface	unfolded protein binding	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|cytoplasm
YBR077C	YBR077C	SLM4	hom	Verified	0.433786921654428	0.332221589791824	no	1707	0.359837292368881	1179	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|SIGNALING			Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4	signal transduction|microautophagy	phosphatidylinositol-3,4-bisphosphate binding	fungal-type vacuole membrane|EGO complex|late endosome membrane|cytoplasm
YER069W	YER069W	ARG5,6	hom	Verified	0.433679481861213	0.332260604154372	no	1708	0.32393907793586	1062	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine	ornithine biosynthetic process|arginine biosynthetic process|regulation of transcription, DNA-dependent	N-acetyl-gamma-glutamyl-phosphate reductase activity|acetylglutamate kinase activity	mitochondrion|mitochondrial matrix
YPL214C	YPL214C	THI6	hom	Verified	0.432314481508093	0.332756431700474	no	1709	0.298575285667062	1005	NA					Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	thiamine biosynthetic process	hydroxyethylthiazole kinase activity|thiamine-phosphate diphosphorylase activity	cytosol|cytoplasm
YGR133W	YGR133W	PEX4	hom	Verified	0.432216825212147	0.332791915945604	no	1710	0.319839939892977	1056	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis	peroxisome organization|protein import into peroxisome matrix, receptor recycling|protein autoubiquitination|protein monoubiquitination|protein polyubiquitination	ubiquitin-protein ligase activity	peroxisome
YCL024W	YCL024W	KCC4	hom	Verified	0.431806090467627	0.332941176300127	no	1711	0.333420374806547	1134	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication	budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly	phosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|protein kinase activity	incipient cellular bud site|cellular bud neck septin collar|plasma membrane|cellular bud neck|septin ring
YCR105W	YCR105W	ADH7	hom	Verified	0.431411598739699	0.333084558893506	no	1712	0.350111018052803	1181	NA	FT	OXIDATION-REDUCTION PROCESS			NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance	alcohol metabolic process	alcohol dehydrogenase (NADP+) activity	cellular_component
YDR128W	YDR128W	MTC5	hom	Verified	0.431179878450864	0.333168791698268	no	1713	0.316597160155551	1056	NA					Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress	biological_process	molecular_function	fungal-type vacuole membrane|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YJR069C	YJR069C	HAM1	hom	Verified	0.431094244653016	0.333199922630285	no	1714	0.318570770972085	1073	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine; protein abundance increases in response to DNA replication stress	purine deoxyribonucleoside triphosphate catabolic process|pyrimidine deoxyribonucleoside triphosphate catabolic process	dITP diphosphatase activity|ITP diphosphatase activity|XTP diphosphatase activity|dCTP diphosphatase activity|UTP diphosphatase activity|dTTP diphosphatase activity|dATP pyrophosphohydrolase activity|dGTP diphosphatase activity|dUTP diphosphatase activity|GTP diphosphatase activity	nucleus|cytoplasm
YLR341W	YLR341W	SPO77	hom	Verified	0.430203670288164	0.333523746185873	no	1715	0.337675268069176	1117	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis	ascospore wall assembly|ascospore formation	molecular_function	intracellular
YHL015W-A_p	YHL015W-A	YHL015W-A	hom	Uncharacterized	0.430170591575484	0.33353577639528	no	1716	0.319808702997418	1101	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGR225W	YGR225W	AMA1	hom	Verified	0.430152925787864	0.333542201235512	no	1717	0.33018442085648	1118	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis	ascospore wall assembly|positive regulation of protein catabolic process|ascospore formation|meiosis I	enzyme activator activity	anaphase-promoting complex
YDL053C	YDL053C	PBP4	hom	Verified	0.429672029857191	0.333717116206538	no	1718	0.339408404098849	1145	NA	FT		NUCLEUS		Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasmic stress granule|cytoplasm
YBR001C	YBR001C	NTH2	hom	Verified	0.429563442060892	0.333756617554428	no	1719	0.396734565030047	1318	NA	FF|FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication	trehalose catabolic process	alpha,alpha-trehalase activity	mitochondrion|cytoplasm
YNR020C	YNR020C	ATP23	hom	Verified	0.429512880542282	0.333775011116866	no	1720	0.346581008414836	1166	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p	protein processing|mitochondrial proton-transporting ATP synthase complex assembly	metalloendopeptidase activity	mitochondrial inner membrane|mitochondrial intermembrane space
YJL122W	YJL122W	ALB1	hom	Verified	0.429286282967751	0.333857449002588	no	1721	0.308149659151499	1065	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p	ribosomal large subunit biogenesis	molecular_function	ribosome|nucleus|cytoplasm
YGR123C	YGR123C	PPT1	hom	Verified	0.428029676715986	0.334314757172639	no	1722	0.336886888687911	1110	NA	FT		NUCLEUS		Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth	protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YNL283C	YNL283C	WSC2	hom	Verified	0.425413975279278	0.335267460023968	no	1723	0.360416148540229	1235	NA	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response	fungal-type cell wall organization|response to heat|Rho protein signal transduction	transmembrane signaling receptor activity	site of polarized growth|cellular bud|mating projection tip|cytoplasm
YCR073W-A	YCR073W-A	SOL2	hom	Verified	0.425106767151548	0.335379422494464	no	1724	0.343851125392866	1184	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication	tRNA export from nucleus	molecular_function|6-phosphogluconolactonase activity	cytosol|cytoplasm
YOR104W	YOR104W	PIN2	hom	Verified	0.425000203037607	0.335418263364616	no	1725	0.343949088931097	1159	NA					Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated	biological_process	molecular_function	cellular_component
YOL035C_d	YOL035C	YOL035C	hom	Dubious	0.424911711136838	0.335450518546693	no	1726	0.326126360063966	1103	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL178W	YGL178W	MPT5	hom	Verified	0.4247929869373	0.335493795267266	no	1727	0.318842906284979	1047	NA	FT	TRANSLATION			mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity	negative regulation of translation|negative regulation of translational initiation|Unknown	mRNA binding|protein binding, bridging	cytoplasm
YFL015C_d	YFL015C	YFL015C	hom	Dubious	0.424117906322144	0.335739913576395	no	1728	0.32983254349597	1077	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene	Unknown	Unknown	Unknown
YMR223W	YMR223W	UBP8	hom	Verified	0.421991198211725	0.336515720989282	no	1729	0.318369629397786	1068	NA	FT	CHROMATIN ORGANIZATION|PROTEOLYSIS	NUCLEUS	HISTONE ACETYLTRANSFERASE	Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B	histone H3-K4 methylation|histone deubiquitination|histone H3-K79 methylation	ubiquitin-specific protease activity|protein complex scaffold	DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YDL065C	YDL065C	PEX19	hom	Verified	0.420562274428543	0.337037373247175	no	1730	0.334728811811415	1112	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning	protein stabilization|protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization|protein exit from endoplasmic reticulum	peroxisome membrane targeting sequence binding|protein binding	cytosol|peroxisomal membrane|endoplasmic reticulum
YPR150W_d	YPR150W	YPR150W	hom	Dubious	0.420157371143417	0.337185246943662	no	1731	0.309147926943679	1055	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C	Unknown	Unknown	Unknown
YER123W	YER123W	YCK3	hom	Verified	0.420112674976657	0.337201571859032	no	1732	0.371913828588419	1260	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE		Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway	vesicle-mediated transport|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	fungal-type vacuole membrane|plasma membrane|nucleus|fungal-type vacuole
YBL103C	YBL103C	RTG3	hom	Verified	0.418688291020539	0.33772197703998	no	1733	0.332421461258586	1125	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways	mitochondrion degradation|cellular response to oleic acid|mitochondria-nucleus signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription factor import into nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus|cytoplasm
YLR412W	YLR412W	BER1	hom	Verified	0.41826602792905	0.337876312485854	no	1734	0.331751106224415	1155	NA	FT		CYTOSKELETON		Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene	biological_process	molecular_function	cytoplasm
YPL107W_p	YPL107W	YPL107W	hom	Uncharacterized	0.417756344277028	0.338062636100411	no	1735	0.323334228495672	1106	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene	biological_process	molecular_function	mitochondrion
YBL043W	YBL043W	ECM13	hom	Verified	0.415174273264977	0.339007165330583	no	1736	0.306736534135832	1022	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cellular_component
YPR002W	YPR002W	PDH1	hom	Verified	0.414788541694569	0.339148354185602	no	1737	0.337136480415287	1133	NA	FT	KETONE METABOLISM	MITOCHONDRION		Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate	propionate metabolic process|propionate catabolic process, 2-methylcitrate cycle	2-methylcitrate dehydratase activity	mitochondrial outer membrane|mitochondrion|cytoplasm
YPR075C	YPR075C	OPY2	hom	Verified	0.413052344346819	0.33978413181601	no	1738	0.327392169837193	1101	NA	FT	CELL CYCLE|SIGNALING	PLASMA MEMBRANE		Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress	cell cycle arrest in response to pheromone|osmosensory signaling pathway	molecular_function	integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YGR164W_d	YGR164W	YGR164W	hom	Dubious	0.412879723973975	0.33984736857741	no	1739	0.339012913260819	1172	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR146C	YDR146C	SWI5	hom	Verified	0.412543622006129	0.33997050718231	no	1740	0.32896796861809	1104	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication	positive regulation of mating type switching|regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter	RNA polymerase II distal enhancer sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|mediator complex binding	nucleus|cytoplasm
YER124C	YER124C	DSE1	hom	Verified	0.412482166609014	0.339993024612495	no	1741	0.341439348233394	1150	NA	FT	CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION	SITE OF POLARIZED GROWTH		Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress	cytokinesis, completion of separation|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|invasive growth in response to glucose limitation	molecular_function	cellular bud neck
YBR285W_p	YBR285W	YBR285W	hom	Uncharacterized	0.411256998979378	0.340442048502014	no	1742	0.357491649332918	1202	NA					Putative protein of unknown function; YBR285W is not an essential gene	biological_process	molecular_function	cellular_component
YBR089C-A	YBR089C-A	NHP6B	hom	Verified	0.411239698383437	0.34044839079145	no	1743	0.316093373600335	1058	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication	RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling|transcription from RNA polymerase II promoter	nucleosome binding|DNA binding, bending|sequence-specific DNA binding	nucleus
YGR143W	YGR143W	SKN1	hom	Verified	0.411122824639397	0.3404912371514	no	1744	0.357836237614685	1182	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p	fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process|sphingolipid biosynthetic process	glucosidase activity	integral to membrane
YOR170W_d	YOR170W	YOR170W	hom	Dubious	0.410431333486901	0.34074478255205	no	1745	0.342045886795062	1156	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4	Unknown	Unknown	Unknown
YHR120W	YHR120W	MSH1	hom	Verified	0.409124074338285	0.341224304897905	no	1746	0.319680414733086	1107	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	MITOCHONDRION		DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis	DNA repair|mismatch repair|mitochondrial DNA repair|mitochondrion organization|reciprocal meiotic recombination|mitochondrial genome maintenance	guanine/thymine mispair binding|dinucleotide insertion or deletion binding|DNA-dependent ATPase activity	mitochondrion
YDR217C	YDR217C	RAD9	hom	Verified	0.407270041923832	0.341904831666379	no	1747	0.333891539536108	1132	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate	DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of cell cycle|intra-S DNA damage checkpoint|nucleotide-excision repair|DNA damage checkpoint|positive regulation of transcription from RNA polymerase II promoter	double-stranded DNA binding|histone binding	chromatin|nucleus
YDL128W	YDL128W	VCX1	hom	Verified	0.406472353723406	0.342197783191974	no	1748	0.318795324593353	1053	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter	manganese ion transport|cellular calcium ion homeostasis|calcium ion transport|transmembrane transport	potassium:hydrogen antiporter activity|calcium:hydrogen antiporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YCL039W	YCL039W	GID7	hom	Verified	0.406255577135058	0.342277410962294	no	1749	0.3386307795366	1130	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process	molecular_function	nucleus|GID complex|cytoplasm
YML051W	YML051W	GAL80	hom	Verified	0.406138528825282	0.342320408815845	no	1750	0.33847598953785	1113	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM	NUCLEUS		Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding	negative regulation of kinase activity|galactose metabolic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity	RNA polymerase II activating transcription factor binding|kinase inhibitor activity	nucleus|cytoplasm
YKL221W	YKL221W	MCH2	hom	Verified	0.406043401732725	0.342355355386568	no	1751	0.355527617046212	1179	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|membrane
YHR073W	YHR073W	OSH3	hom	Verified	0.405598907632228	0.342518665811612	no	1752	0.333901916180948	1110	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	karyogamy involved in conjugation with cellular fusion|endocytosis|exocytosis|positive regulation of phosphatase activity|maintenance of cell polarity|pseudohyphal growth|sterol transport|invasive growth in response to glucose limitation	lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity	cortical endoplasmic reticulum|cytoplasm
YLL015W	YLL015W	BPT1	hom	Verified	0.404072069116386	0.343079861713798	no	1753	0.305576342515674	1013	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p	cadmium ion transport|bilirubin transport	bilirubin transmembrane transporter activity|cadmium ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YML014W	YML014W	TRM9	hom	Verified	0.403148033928696	0.343419663019912	no	1754	0.313672681432457	1079	NA	FT	RNA PROCESSING	NUCLEUS		tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses	chronological cell aging|tRNA methylation|tRNA wobble uridine modification|response to stress	tRNA (uracil) methyltransferase activity	nucleus|cytoplasm
YJR019C	YJR019C	TES1	hom	Verified	0.402793545358602	0.343550054959796	no	1755	0.342398607637328	1160	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids	fatty acid beta-oxidation|fatty acid oxidation	acyl-CoA hydrolase activity	mitochondrion|peroxisome
YER081W	YER081W	SER3	hom	Verified	0.401913992133592	0.343873662421024	no	1756	0.344411580416399	1136	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication	serine family amino acid biosynthetic process	phosphoglycerate dehydrogenase activity	cytoplasm
YLR358C_p	YLR358C	YLR358C	hom	Uncharacterized	0.401583519701142	0.343995280261803	no	1757	0.305882306894748	1040	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W	biological_process	molecular_function	cellular_component
YBR222C	YBR222C	PCS60	hom	Verified	0.400295098158453	0.344469588964792	no	1758	0.318168655238269	1058	NA					Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase	biological_process	mRNA binding|AMP binding	integral to membrane|peroxisomal matrix|peroxisomal membrane|cytoplasm
YPR058W	YPR058W	YMC1	hom	Verified	0.400269047983709	0.344479181383552	no	1759	0.339454151271903	1104	NA	FT		MITOCHONDRION		Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication	mitochondrial transport	organic acid transmembrane transporter activity	mitochondrion|integral to membrane
YPL079W	YPL079W	RPL21B	hom	Verified	0.399183637422555	0.344878949409121	no	1760	0.332937071968248	1146	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YNL286W	YNL286W	CUS2	hom	Verified	0.398261948355173	0.345218553137735	no	1761	0.348514874833682	1155	NA	FT	RNA PROCESSING	NUCLEUS		Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)	mRNA splicing, via spliceosome	RNA binding	U2 snRNP
YOR264W	YOR264W	DSE3	hom	Verified	0.397605339325265	0.345460562065418	no	1762	0.332907528767581	1118	NA	FT	CELL CYCLE	SITE OF POLARIZED GROWTH		Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cellular bud neck
YBL036C	YBL036C	YBL036C	hom	Verified	0.395881044644283	0.346096392647499	no	1763	0.310969513720407	1055	NA					Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS	biological_process	pyridoxal phosphate binding	cellular_component
YDL059C	YDL059C	RAD59	hom	Verified	0.395653847014163	0.346180203775025	no	1764	0.359426306534686	1196	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p	DNA strand renaturation|telomere maintenance via recombination|double-strand break repair via break-induced replication|double-strand break repair via single-strand annealing	protein binding	nucleus
YDR127W	YDR127W	ARO1	hom	Verified	0.395383693649444	0.346279870685465	no	1765	0.419600370720748	1371	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids	aromatic amino acid family biosynthetic process	shikimate kinase activity|shikimate 3-dehydrogenase (NADP+) activity|3-phosphoshikimate 1-carboxyvinyltransferase activity|3-dehydroquinate dehydratase activity|3-dehydroquinate synthase activity	cytoplasm
YGR019W	YGR019W	UGA1	hom	Verified	0.395374830205974	0.3462831408308	no	1766	0.338310348860372	1134	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress	nitrogen utilization|gamma-aminobutyric acid catabolic process	4-aminobutyrate transaminase activity	intracellular
YLR112W_d	YLR112W	YLR112W	hom	Dubious	0.395198174063425	0.34634832006354	no	1767	0.329048293137881	1075	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER139C	YER139C	RTR1	hom	Verified	0.395075665094774	0.34639352377134	no	1768	0.329911414095476	1110	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication	dephosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter	CTD phosphatase activity	nucleus|cytoplasm
YLR306W	YLR306W	UBC12	hom	Verified	0.394980108126188	0.346428784172362	no	1769	0.335769095330568	1122	NA					Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes	protein neddylation	NEDD8 ligase activity	cellular_component
YNL057W_d	YNL057W	YNL057W	hom	Dubious	0.394738608030661	0.346517903334717	no	1770	0.340261577844048	1166	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR196W_p	YMR196W	YMR196W	hom	Uncharacterized	0.39464746776895	0.346551538423356	no	1771	0.358768132283813	1216	NA	FT	CARBOHYDRATE METABOLISM			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene	biological_process	molecular_function	cytoplasm
YLR133W	YLR133W	CKI1	hom	Verified	0.394097738818668	0.346754440183176	no	1772	0.382334372857059	1288	NA	FT	LIPID METABOLISM			Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolamine kinase activity|choline kinase activity	cytoplasm
YOL039W	YOL039W	RPP2A	hom	Verified	0.394012863247987	0.346785771182026	no	1773	0.357951942166072	1208	NA	FT	TRANSLATION		RIBOSOME	Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	translational elongation|cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YHR049C-A_d	YHR049C-A	YHR049C-A	hom	Dubious	0.393050780141538	0.34714098809418	no	1774	0.331754799681356	1134	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL065C	YKL065C	YET1	hom	Verified	0.391843658038023	0.347586867437319	no	1775	0.330439853535396	1122	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein	biological_process	molecular_function	ribosome|integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YGR111W_p	YGR111W	YGR111W	hom	Uncharacterized	0.391695136849934	0.347641741866239	no	1776	0.375463294277802	1242	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	regulation of cell size	molecular_function	nucleus|cytoplasm
YMR106C	YMR106C	YKU80	hom	Verified	0.391246503663534	0.347807518674513	no	1777	0.338644729099711	1156	NA	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair	chromatin assembly or disassembly|protein localization to chromosome|chromatin silencing|double-strand break repair via nonhomologous end joining|donor selection|telomere maintenance|double-strand break repair via homologous recombination	damaged DNA binding|RNA binding|DNA binding|telomeric DNA binding	nuclear chromatin|nuclear telomeric heterochromatin|Ku70:Ku80 complex
YOR385W_p	YOR385W	YOR385W	hom	Uncharacterized	0.39077660878246	0.347981183205053	no	1778	0.350019022387484	1167	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene	biological_process	molecular_function	cytoplasm
YNL228W_d	YNL228W	YNL228W	hom	Dubious	0.390096431035733	0.348232620910971	no	1779	0.365458410892336	1219	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1	Unknown	Unknown	Unknown
YML113W	YML113W	DAT1	hom	Verified	0.389876876282113	0.348313796803943	no	1780	0.336953223773824	1133	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability	negative regulation of transcription from RNA polymerase II promoter	AT DNA binding	nucleus
YFL027C	YFL027C	GYP8	hom	Verified	0.389547067838935	0.348435749808634	no	1781	0.333460240650413	1127	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM			GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport	vesicle-mediated transport	Rab GTPase activator activity	intracellular
YDR269C_d	YDR269C	YDR269C	hom	Dubious	0.388795624894204	0.348713668769322	no	1782	0.340561227985709	1122	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL104C	YDL104C	QRI7	hom	Verified	0.388317114462573	0.34889068677313	no	1783	0.36038842426328	1175	NA	FT	RNA PROCESSING|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification	mitochondrial tRNA threonylcarbamoyladenosine modification	molecular_function	mitochondrion
YLR001C_p	YLR001C	YLR001C	hom	Uncharacterized	0.388231571447877	0.348922335639465	no	1784	0.329724642853129	1120	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated	biological_process	molecular_function	mitochondrion|fungal-type vacuole membrane
YBR244W	YBR244W	GPX2	hom	Verified	0.388135994453524	0.348957698081167	no	1785	0.311381134561929	1063	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress	phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity	extrinsic to mitochondrial inner membrane|extrinsic to mitochondrial outer membrane|nucleus|cytoplasm
YGR071C	YGR071C	ENV11	hom	Verified	0.388121216056133	0.348963166043545	no	1786	0.340891207467393	1137	NA	FT	VACUOLAR PROTEIN PROCESSING	NUCLEUS		Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	vacuole organization|vacuolar protein processing	molecular_function	nucleus
YPR069C	YPR069C	SPE3	hom	Verified	0.388045383925063	0.348991224196237	no	1787	0.381265733690046	1248	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells	spermidine biosynthetic process|pantothenate biosynthetic process	spermidine synthase activity	nucleus|cytoplasm
YML124C	YML124C	TUB3	hom	Verified	0.387220130575092	0.349296624166527	no	1788	0.39828633420623	1325	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication	nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation	structural constituent of cytoskeleton	tubulin complex|cytoplasmic microtubule|kinetochore microtubule|nuclear microtubule|spindle pole body|polar microtubule
YML094C-A_d	YML094C-A	YML094C-A	hom	Dubious	0.386239370571503	0.349659699109598	no	1789	0.339179786691976	1166	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YJL067W_d	YJL067W	YJL067W	hom	Dubious	0.384862001062921	0.350169830101578	no	1790	0.335153091995724	1118	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR537C_d	YDR537C	YDR537C	hom	Dubious	0.384717201991541	0.350223474497863	no	1791	0.354398955344149	1165	NA					Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W	Unknown	Unknown	Unknown
YOL103W	YOL103W	ITR2	hom	Verified	0.384358556087461	0.350356356606531	no	1792	0.354292980901241	1182	NA	FT		PLASMA MEMBRANE		Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively	myo-inositol transport	myo-inositol transmembrane transporter activity	integral to membrane|plasma membrane|membrane
YOR172W	YOR172W	YRM1	hom	Verified	0.383469695168978	0.350685767927934	no	1793	0.351129168652225	1156	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|nucleic acid binding transcription factor activity	nucleus|cytoplasm
YOR193W	YOR193W	PEX27	hom	Verified	0.382985405240547	0.350865292759162	no	1794	0.348746415727863	1156	NA	FT	PEROXISOME ORGANIZATION			Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p	peroxisome organization	molecular_function	peroxisomal membrane
YDR295C	YDR295C	HDA2	hom	Verified	0.38227090964943	0.351130214939026	no	1795	0.331462002256361	1115	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance	negative regulation of transcription from RNA polymerase II promoter|gene silencing by RNA|histone deacetylation|gene silencing involved in chronological cell aging	histone deacetylase activity|chromatin binding|DNA binding	nucleus|HDA1 complex
YAL015C	YAL015C	NTG1	hom	Verified	0.382028909421816	0.351219960705383	no	1796	0.335861667195759	1133	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication	DNA repair|cellular response to oxidative stress|base-excision repair|base-excision repair, AP site formation|positive regulation of mitochondrial DNA replication	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|oxidized purine nucleobase lesion DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity	mitochondrion|nucleus
YDR248C_p	YDR248C	YDR248C	hom	Uncharacterized	0.381280015804789	0.351497740396774	no	1797	0.340628361911121	1132	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM			Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1	biological_process	molecular_function	cytoplasm
YKL190W	YKL190W	CNB1	hom	Verified	0.381018730105416	0.351594675186772	no	1798	0.351646510211596	1183	NA	FF|FT	SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding	calcineurin complex
YOR020W-A_p	YOR020W-A	YOR020W-A	hom	Uncharacterized	0.380994823607719	0.351603544777703	no	1799	0.349975856820176	1161	NA	FT		MITOCHONDRION		Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YNL059C	YNL059C	ARP5	hom	Verified	0.37943253387397	0.352183347528695	no	1800	0.368296106955152	1227	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes	nucleosome mobilization|chromatin remodeling	ATP-dependent 3'-5' DNA helicase activity	nucleus|Ino80 complex
YNL011C_p	YNL011C	YNL011C	hom	Uncharacterized	0.378960990676606	0.352358415985884	no	1801	0.312801301548653	1092	NA					Putative protein of unknown function; YNL011C is not an essential gene	biological_process	molecular_function	cellular_component
YGL256W	YGL256W	ADH4	hom	Verified	0.378738665758558	0.352440968760037	no	1802	0.3424432952258	1174	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency	fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	mitochondrion
YNL129W	YNL129W	NRK1	hom	Verified	0.378421953203912	0.352558581167165	no	1803	0.338465044774849	1149	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis	nicotinamide riboside metabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|NAD biosynthetic process	nicotinic acid riboside kinase activity|ribosylnicotinamide kinase activity	cytoplasm
YOR080W	YOR080W	DIA2	hom	Verified	0.377667008403612	0.3528389896104	no	1804	0.359749773926208	1204	NA	FT	CELL CYCLE|PROTEOLYSIS	NUCLEUS|CHROMOSOME	UBIQUITIN LIGASE COMPLEX	Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA replication|invasive growth in response to glucose limitation|protein ubiquitination	ubiquitin-protein ligase activity|DNA replication origin binding	SCF ubiquitin ligase complex|nucleus|nuclear replication fork
YGL146C_p	YGL146C	RRT6	hom	Uncharacterized	0.37693613132857	0.353110534779983	no	1805	0.334523131883989	1106	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins	biological_process	molecular_function	membrane
YBR023C	YBR023C	CHS3	hom	Verified	0.375853878850466	0.353512764995882	no	1806	0.380618516233194	1269	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH		Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan	ascospore wall assembly|fungal-type cell wall chitin biosynthetic process|cytokinesis	chitin synthase activity	incipient cellular bud site|integral to membrane|chitosome|prospore membrane|cellular bud neck|mating projection tip|cytoplasm
YBR041W	YBR041W	FAT1	hom	Verified	0.375455816912098	0.353660749977931	no	1807	0.397340177282369	1298	NA	FT	KETONE METABOLISM|LIPID METABOLISM	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids	very long-chain fatty acid metabolic process|long-chain fatty acid transport	very long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity	intrinsic to internal side of plasma membrane|integral to membrane|endoplasmic reticulum|lipid particle|peroxisome
YNR019W	YNR019W	ARE2	hom	Verified	0.375014647958122	0.353824786424394	no	1808	0.356742818209629	1179	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication	ergosterol metabolic process	ergosterol O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YMR010W_p	YMR010W	YMR010W	hom	Uncharacterized	0.374655276174755	0.353958428920969	no	1809	0.353257265634127	1146	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1	biological_process	molecular_function	integral to membrane|cytoplasm
YLR322W_d	YLR322W	VPS65	hom	Dubious	0.374084387674619	0.354170766845436	no	1810	0.357094119150626	1207	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth	Unknown	Unknown	Unknown
YDR345C	YDR345C	HXT3	hom	Verified	0.373538793322206	0.354373739174324	no	1811	0.381435939291478	1268	NA	FT		PLASMA MEMBRANE		Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication	hexose transport|transmembrane transport	mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YIL088C	YIL088C	AVT7	hom	Verified	0.372727506896115	0.354675630902626	no	1812	0.337940533512383	1107	NA	FT		PLASMA MEMBRANE		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane|fungal-type vacuole
YBR139W	YBR139W	YBR139W	hom	Verified	0.372492280601191	0.35476317918207	no	1813	0.364731760406503	1187	NA	FT	PROTEOLYSIS			Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner	phytochelatin biosynthetic process	serine hydrolase activity|serine-type carboxypeptidase activity	fungal-type vacuole
YMR209C_p	YMR209C	YMR209C	hom	Uncharacterized	0.371073953751805	0.3552912250929	no	1814	0.357756287805194	1183	NA					Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YPR152C	YPR152C	URN1	hom	Verified	0.369019031393317	0.356056769677662	no	1815	0.353050943118115	1175	NA	FT	RNA PROCESSING	NUCLEUS		Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase	biological_process	molecular_function	nucleus
YDR042C_p	YDR042C	YDR042C	hom	Uncharacterized	0.368615268337147	0.356207256666445	no	1816	0.342458882255106	1131	NA					Putative protein of unknown function; expression is increased in ssu72-ts69 mutant	biological_process	molecular_function	cellular_component
YDL054C	YDL054C	MCH1	hom	Verified	0.368248835177029	0.356343849776194	no	1817	0.360202877252488	1244	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|membrane
YDR502C	YDR502C	SAM2	hom	Verified	0.367139925839496	0.356757323545311	no	1818	0.340950803214994	1141	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication	methionine metabolic process|S-adenosylmethionine biosynthetic process	methionine adenosyltransferase activity	cellular_component
YOR113W	YOR113W	AZF1	hom	Verified	0.367101591102879	0.35677162025026	no	1819	0.377922778066605	1261	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL WALL ORG/BIOGENESIS	NUCLEUS		Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity	regulation of fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|cellular response to carbohydrate stimulus	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YNL080C	YNL080C	EOS1	hom	Verified	0.366960566049953	0.356824216410333	no	1820	0.371047430957516	1237	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene	cellular response to oxidative stress|protein N-linked glycosylation	molecular_function	integral to membrane|endoplasmic reticulum membrane
YKL098W	YKL098W	MTC2	hom	Verified	0.363890553934894	0.357969869335093	no	1821	0.395883230788027	1307	NA					Protein of unknown function; mtc2 is synthetically sick with cdc13-1	biological_process	molecular_function	cellular_component
YAL053W	YAL053W	FLC2	hom	Verified	0.363408039885321	0.358150048387388	no	1822	0.373051114528842	1275	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication	protein folding|fungal-type cell wall biogenesis|FAD transport|transmembrane transport	FAD transmembrane transporter activity	integral to membrane|endoplasmic reticulum|cytoplasm
YOR163W	YOR163W	DDP1	hom	Verified	0.362236141527895	0.358587786897397	no	1823	0.34445667354006	1146	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress	polyphosphate catabolic process|inositol phosphate dephosphorylation|diadenosine polyphosphate catabolic process	diphosphoinositol-polyphosphate diphosphatase activity|endopolyphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|bis(5'-adenosyl)-hexaphosphatase activity	nucleus|cytoplasm
YCL010C	YCL010C	SGF29	hom	Verified	0.362217305459643	0.358594824242078	no	1824	0.346278672790124	1155	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation	histone H3-K14 acetylation|cellular protein complex localization|histone H3-K18 acetylation|cellular protein localization|histone H3-K9 acetylation|positive regulation of transcription from RNA polymerase II promoter	methylated histone residue binding|RNA polymerase II transcription factor recruiting transcription factor activity	Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YJL093C	YJL093C	TOK1	hom	Verified	0.361442025889415	0.358884518125665	no	1825	0.362347912965663	1200	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin	cellular potassium ion homeostasis	potassium channel activity	integral to membrane|plasma membrane
YLR013W	YLR013W	GAT3	hom	Verified	0.360827045645639	0.35911437171083	no	1826	0.356342424651265	1172	NA	FT		NUCLEUS		Protein containing GATA family zinc finger motifs	transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YPR084W_p	YPR084W	YPR084W	hom	Uncharacterized	0.360112333808636	0.359381564828995	no	1827	0.364698489512316	1194	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBL052C	YBL052C	SAS3	hom	Verified	0.359472367743803	0.359620872807494	no	1828	0.347952907565044	1150	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal	histone acetylation|chromatin modification|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	histone acetyltransferase activity	NuA3 histone acetyltransferase complex
YBR085C-A	YBR085C-A	YBR085C-A	hom	Verified	0.35850990373404	0.359980878840051	no	1829	0.349865888042875	1200	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YER019C-A	YER019C-A	SBH2	hom	Verified	0.358489832868674	0.359988387595015	no	1830	0.353501816686945	1183	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p	SRP-dependent cotranslational protein targeting to membrane	ARF guanyl-nucleotide exchange factor activity	Ssh1 translocon complex
YAR031W	YAR031W	PRM9	hom	Verified	0.358335999662177	0.360045940263225	no	1831	0.358808784492957	1194	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family	vesicle organization	molecular_function	integral to membrane|endoplasmic reticulum|plasma membrane
YGR275W	YGR275W	RTT102	hom	Verified	0.358208643209087	0.360093589747663	no	1832	0.372620143895149	1209	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS	RSC COMPLEX	Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress	chromosome segregation|nucleosome disassembly|chromatin remodeling|transcription elongation from RNA polymerase II promoter	molecular_function	RSC complex|SWI/SNF complex|nucleus
YPR157W_p	YPR157W	TDA6	hom	Uncharacterized	0.357994624792023	0.36017366806699	no	1833	0.352660734025607	1183	NA	FT	PROTEIN LOCALIZATION			Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	cellular_component
YLL062C	YLL062C	MHT1	hom	Verified	0.357329659068535	0.360422514467958	no	1834	0.359833987359679	1202	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio	sulfur amino acid metabolic process	homocysteine S-methyltransferase activity	cytoplasm
YBR083W	YBR083W	TEC1	hom	Verified	0.357145835975708	0.360491315992555	no	1835	0.337376072909939	1158	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member	pseudohyphal growth|chronological cell aging|positive regulation of transposition, RNA-mediated|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YIL052C	YIL052C	RPL34B	hom	Verified	0.356499322935405	0.360733329524958	no	1836	0.378398597782895	1265	NA	FF|FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YMR156C	YMR156C	TPP1	hom	Verified	0.356348723513615	0.36078971242376	no	1837	0.3606809776185	1191	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3&#8242;-phosphatase	DNA repair	polynucleotide 3'-phosphatase activity	cellular_component
YDL085C-A_p	YDL085C-A	YDL085C-A	hom	Uncharacterized	0.356300219781813	0.360807872374153	no	1838	0.36738664535855	1222	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YGR163W	YGR163W	GTR2	hom	Verified	0.356056148458427	0.360899258210836	no	1839	0.387841588933884	1282	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION	NUCLEUS|CHROMOSOME		Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD	microautophagy|positive regulation of transcription from RNA polymerase II promoter	GTP binding	nuclear chromatin|fungal-type vacuole membrane|integral to membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YPL056C_p	YPL056C	LCL1	hom	Uncharacterized	0.353387721307281	0.361898894875621	no	1840	0.349812464165545	1190	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan	biological_process	molecular_function	cellular_component
YNL284C	YNL284C	MRPL10	hom	Verified	0.353356853387545	0.361910464035521	no	1841	0.365492490565778	1235	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YIR032C	YIR032C	DAL3	hom	Verified	0.353119692156156	0.361999355225488	no	1842	0.37027776436079	1236	NA	FT		PLASMA MEMBRANE		Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression	allantoin catabolic process	ureidoglycolate hydrolase activity	membrane
YDR105C	YDR105C	TMS1	hom	Verified	0.352818709614607	0.362112178211688	no	1843	0.36903745267173	1236	NA					Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane|membrane
YER187W_p	YER187W	YER187W	hom	Uncharacterized	0.352668708128303	0.362168410583764	no	1844	0.347892330200531	1167	NA					Putative protein of unknown function; induced in respiratory-deficient cells	biological_process	molecular_function	cellular_component
YPL119C	YPL119C	DBP1	hom	Verified	0.351830426715448	0.362482719220042	no	1845	0.355537226617409	1180	NA	FT	TRANSLATION			Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress	translational initiation	RNA helicase activity	cytoplasm
YPL021W	YPL021W	ECM23	hom	Verified	0.351361429260032	0.362658607488187	no	1846	0.33893753975591	1128	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p	pseudohyphal growth	sequence-specific DNA binding	cellular_component
YBR009C	YBR009C	HHF1	hom	Verified	0.350516374374929	0.362975601841977	no	1847	0.318258456083825	1063	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity	chromatin assembly or disassembly|sexual sporulation resulting in formation of a cellular spore|histone H3-K79 methylation	DNA binding	replication fork protection complex|nuclear nucleosome
YHR202W_p	YHR202W	YHR202W	hom	Uncharacterized	0.349885026216717	0.363212492494674	no	1848	0.364130775926388	1229	NA	FT	NUCLEOTIDE METABOLISM			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization	biological_process	molecular_function	cytosol|fungal-type vacuole
YDR183W	YDR183W	PLP1	hom	Verified	0.349522705654313	0.363348463873876	no	1849	0.345595175825093	1129	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING			Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators	protein folding|positive regulation of transcription from RNA polymerase II promoter by pheromones	G-protein beta/gamma-subunit complex binding	cellular_component
YNR065C_p	YNR065C	YNR065C	hom	Uncharacterized	0.348588147409084	0.363699263621858	no	1850	0.339596730604351	1177	NA					Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene	biological_process	molecular_function	integral to membrane
YHR029C	YHR029C	YHI9	hom	Verified	0.347341730570245	0.364167301765228	no	1851	0.372266490932375	1228	NA	FT	SIGNALING			Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production	endoplasmic reticulum unfolded protein response	molecular_function	cellular_component
YDL176W	YDL176W	YDL176W	hom	Verified	0.347286128477202	0.364188185462694	no	1852	0.346025789109643	1145	NA					Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene	biological_process	molecular_function	cellular_component
YLR328W	YLR328W	NMA1	hom	Verified	0.346071950103294	0.364644321515381	no	1853	0.389187809838984	1272	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication	NAD biosynthetic process	nicotinamide-nucleotide adenylyltransferase activity	nucleus|cytoplasm
YLR099C	YLR099C	ICT1	hom	Verified	0.345221155375175	0.364964057803834	no	1854	0.368519591886207	1240	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication	phosphatidic acid biosynthetic process	lysophosphatidic acid acyltransferase activity	cellular_component
YKL120W	YKL120W	OAC1	hom	Verified	0.343981987428509	0.365429916197421	no	1855	0.359549249953207	1218	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family	sulfate transport|oxaloacetate transport|isopropylmalate transport	secondary active sulfate transmembrane transporter activity|oxaloacetate secondary active transmembrane transporter activity|isopropylmalate transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YBR175W	YBR175W	SWD3	hom	Verified	0.34383414901076	0.3654855085135	no	1856	0.359999644066203	1178	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5	histone H3-K4 methylation|telomere maintenance|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YNL279W	YNL279W	PRM1	hom	Verified	0.342341942309139	0.366046787448632	no	1857	0.371432995075193	1216	NA	FT	MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p	plasma membrane fusion involved in cytogamy|response to pheromone	molecular_function	integral to membrane|mating projection tip
YLR401C	YLR401C	DUS3	hom	Verified	0.342198256347364	0.366100848671043	no	1858	0.318017785743704	1051	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	NUCLEUS		Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress	tRNA modification	tRNA dihydrouridine synthase activity	nucleus|cytoplasm
YLR121C	YLR121C	YPS3	hom	Verified	0.341605767804226	0.366323797994662	no	1859	0.372214340573245	1265	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	PLASMA MEMBRANE		Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	fungal-type cell wall organization|cellular protein metabolic process	aspartic-type endopeptidase activity	anchored to plasma membrane|plasma membrane
YGR124W	YGR124W	ASN2	hom	Verified	0.340918800012534	0.366582355695934	no	1860	0.358963780014172	1222	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication	asparagine biosynthetic process	asparagine synthase (glutamine-hydrolyzing) activity	cytoplasm
YMR144W_p	YMR144W	YMR144W	hom	Uncharacterized	0.340391013070272	0.366781042802338	no	1861	0.363181368021745	1184	NA	FT		NUCLEUS		Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene	biological_process	molecular_function	nucleus
YDR378C	YDR378C	LSM6	hom	Verified	0.339667466385782	0.367053482303525	no	1862	0.375163112019887	1258	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasmic mRNA processing body
YJL127C-B_p	YJL127C-B	YJL127C-B	hom	Uncharacterized	0.33890113372787	0.367342105171767	no	1863	0.355616488889266	1170	NA					Putative protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i>	biological_process	molecular_function	cellular_component
YAL031C	YAL031C	GIP4	hom	Verified	0.338149559747832	0.367625242315836	no	1864	0.359557454442909	1189	NA	FT	CHROMOSOME SEGREGATION			Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate	chromosome segregation|regulation of phosphoprotein phosphatase activity	protein phosphatase 1 binding|protein phosphatase type 1 regulator activity	cytoplasm
YOR367W	YOR367W	SCP1	hom	Verified	0.337664514506426	0.36780800948499	no	1865	0.37944633080912	1259	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin	actin filament organization|chronological cell aging	actin filament binding|protein binding, bridging	actin cortical patch
YBR030W	YBR030W	RKM3	hom	Verified	0.3364809759549	0.368254097555422	no	1866	0.339162590110744	1143	NA	FT		NUCLEUS		Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein	peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	nucleus
YGL180W	YGL180W	ATG1	hom	Verified	0.335099994472254	0.368774828514981	no	1867	0.367127114823541	1215	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p	piecemeal microautophagy of nucleus|mitochondrion degradation|protein phosphorylation|CVT pathway|autophagic vacuole assembly	protein serine/threonine kinase activity|protein kinase activity	cytosol|pre-autophagosomal structure|Atg1p signaling complex
YDR348C	YDR348C	PAL1	hom	Verified	0.334580264888131	0.368970867030242	no	1868	0.374934397113967	1255	NA	FT		SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cell cortex|cellular bud neck|mating projection tip
YGR284C	YGR284C	ERV29	hom	Verified	0.330396027419833	0.370550371412504	no	1869	0.37491321863265	1233	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|ER to Golgi transport vesicle
YLR422W_p	YLR422W	YLR422W	hom	Uncharacterized	0.329666963554303	0.37082580936578	no	1870	0.376354503297243	1239	NA					Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein	biological_process	molecular_function	cytoplasm
YBR228W	YBR228W	SLX1	hom	Verified	0.328661001435586	0.371205967253381	no	1871	0.365762110428567	1255	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p	DNA-dependent DNA replication	5'-flap endonuclease activity	Slx1-Slx4 complex|nucleus
YEL071W	YEL071W	DLD3	hom	Verified	0.328626532797829	0.371218995345575	no	1872	0.367007619618769	1214	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS			D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm	lactate metabolic process|filamentous growth	D-lactate dehydrogenase (cytochrome) activity	cytoplasm
YML034C-A_d	YML034C-A	YML034C-A	hom	Dubious	0.328056359741627	0.371434524744931	no	1873	0.393028100136528	1300	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR486C	YDR486C	VPS60	hom	Verified	0.327262224713639	0.371734780504896	no	1874	0.378496401751536	1250	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p	late endosome to vacuole transport via multivesicular body sorting pathway|filamentous growth	molecular_function	fungal-type vacuole membrane|cytoplasm
YDR011W	YDR011W	SNQ2	hom	Verified	0.326466675430321	0.372035649235108	no	1875	0.391333111797317	1302	NA	FF|FT	NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species	response to drug	xenobiotic-transporting ATPase activity	mitochondrion|integral to membrane|plasma membrane
YPL270W	YPL270W	MDL2	hom	Verified	0.326240835248191	0.37212107396777	no	1876	0.372974411452397	1259	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis	oligopeptide transport|oligopeptide export from mitochondrion	oligopeptide-transporting ATPase activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YKR082W	YKR082W	NUP133	hom	Verified	0.325813092012035	0.372282886388805	no	1877	0.371807822244209	1220	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133	poly(A)+ mRNA export from nucleus|double-strand break repair|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|tRNA export from nucleus|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore outer ring
YGR053C_p	YGR053C	YGR053C	hom	Uncharacterized	0.323584113952053	0.373126458324356	no	1878	0.372359249464255	1237	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YCL028W	YCL028W	RNQ1	hom	Verified	0.32280659013294	0.37342086089115	no	1879	0.358925502093048	1218	NA	FT		NUCLEUS		[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate	biological_process	molecular_function	cytosol
YDR073W	YDR073W	SNF11	hom	Verified	0.322653528440774	0.373478825067885	no	1880	0.357512809905756	1178	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex
YBR003W	YBR003W	COQ1	hom	Verified	0.322364388412709	0.373588329666678	no	1881	0.397791969679686	1304	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis	ubiquinone biosynthetic process	trans-hexaprenyltranstransferase activity	mitochondrion
YBR118W	YBR118W	TEF2	hom	Verified	0.321744354388573	0.373823186544377	no	1882	0.356901352427346	1181	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION	CYTOSKELETON	RIBOSOME	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication	translational elongation|tRNA export from nucleus	GDP binding|GTP binding|translation elongation factor activity	ribosome|eukaryotic translation elongation factor 1 complex|cytoplasm
YLR048W	YLR048W	RPS0B	hom	Verified	0.321487353527178	0.373920547233057	no	1883	0.343642332465599	1141	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YBR299W	YBR299W	MAL32	hom	Verified	0.321174727478932	0.374038991483157	no	1884	0.374457755906147	1260	NA	FT	CARBOHYDRATE METABOLISM			Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose	sucrose catabolic process|maltose catabolic process	sucrose alpha-glucosidase activity|alpha-glucosidase activity|maltose alpha-glucosidase activity	plasma membrane
YCR020C-A	YCR020C-A	MAK31	hom	Verified	0.321069515662221	0.374078855631334	no	1885	0.358048248704527	1193	NA					Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex
YAR020C	YAR020C	PAU7	hom	Verified	0.320799882350142	0.374181024278969	no	1886	0.379159911777875	1242	NA					Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YLR335W	YLR335W	NUP2	hom	Verified	0.320107893711258	0.374443270972575	no	1887	0.391076178673158	1316	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CHROMOSOME	NUCLEAR PORE	Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization	rRNA export from nucleus|snRNA export from nucleus|nuclear pore organization|tRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA-binding (hnRNP) protein import into nucleus|ribosomal protein import into nucleus|snRNP protein import into nucleus|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|protein targeting to membrane|poly(A)+ mRNA export from nucleus|protein export from nucleus|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, non-stop decay	nucleocytoplasmic transporter activity	nuclear chromatin|mitochondrion|integral to membrane|nuclear pore
YKL201C	YKL201C	MNN4	hom	Verified	0.320031915357311	0.37447206844378	no	1888	0.371466370135994	1247	NA	FT	CARBOHYDRATE METABOLISM			Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication	protein O-linked glycosylation|protein N-linked glycosylation|response to stress	molecular_function	membrane
YPL081W	YPL081W	RPS9A	hom	Verified	0.319787169647429	0.374564837223666	no	1889	0.379157768672063	1266	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome|rRNA binding	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome|cytoplasm
YHR043C	YHR043C	DOG2	hom	Verified	0.318306254040724	0.375126320399705	no	1890	0.363233715135044	1207	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, paralogous to DOG1, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed	glucose metabolic process	2-deoxyglucose-6-phosphatase activity	nucleus|cytoplasm
YML019W	YML019W	OST6	hom	Verified	0.318150265715645	0.375185478174181	no	1891	0.388336485164224	1290	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p	protein N-linked glycosylation via asparagine|protein complex assembly	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex|integral to membrane
YBR145W	YBR145W	ADH5	hom	Verified	0.317744807760046	0.375339259760557	no	1892	0.37576530526374	1248	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	NUCLEUS		Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication	NADH oxidation|ethanol biosynthetic process involved in glucose fermentation to ethanol|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	nucleus|cytoplasm
YIL009C-A	YIL009C-A	EST3	hom	Verified	0.317685223675648	0.375361860407895	no	1893	0.379158002797094	1267	NA	FT		NUCLEUS|CHROMOSOME		Component of the telomerase holoenzyme, involved in telomere replication	telomere maintenance via telomerase	ATP-dependent DNA/RNA helicase activity|GTPase activity|telomeric DNA binding	chromosome, telomeric region|nucleus|telomerase holoenzyme complex
YOR072W_d	YOR072W	YOR072W	hom	Dubious	0.3161767619342	0.375934172495735	no	1894	0.407690620894021	1350	NA	FF				Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive	Unknown	Unknown	Unknown
YDR458C	YDR458C	HEH2	hom	Verified	0.315302386126963	0.376266036735012	no	1895	0.383363658075479	1269	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle	biological_process	molecular_function	nuclear envelope
YDR334W	YDR334W	SWR1	hom	Verified	0.313715567477439	0.376868538060594	no	1896	0.397511441434406	1296	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A	chromatin remodeling|histone exchange	structural molecule activity	Swr1 complex|nucleus
YLR395C	YLR395C	COX8	hom	Verified	0.312476257186962	0.377339302184657	no	1897	0.384001756206514	1287	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YMR194C-B	YMR194C-B	CMC4	hom	Verified	0.312355951536828	0.377385011181411	no	1898	0.368276345229584	1197	NA	FT		MITOCHONDRION		Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs	biological_process	molecular_function	mitochondrial intermembrane space
YKL053W_d	YKL053W	YKL053W	hom	Dubious	0.311934873018923	0.377545009515071	no	1899	0.358811973105849	1200	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1	Unknown	Unknown	Unknown
YIR020C_p	YIR020C	YIR020C	hom	Uncharacterized	0.311733302616316	0.377621608201569	no	1900	0.353314162654949	1167	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YHR033W_p	YHR033W	YHR033W	hom	Uncharacterized	0.311564376874789	0.377685805310996	no	1901	0.363366629570258	1218	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YKR034W	YKR034W	DAL80	hom	Verified	0.309182176230605	0.378591475715198	no	1902	0.374203848140762	1236	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication	nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YOL082W	YOL082W	ATG19	hom	Verified	0.308648272927864	0.378794547977904	no	1903	0.358117543608675	1186	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles	vesicle organization|ER-associated protein catabolic process|protein processing|protein complex localization|CVT pathway	protein binding, bridging	pre-autophagosomal structure|cytoplasm|CVT complex|extrinsic to membrane
YDL048C	YDL048C	STP4	hom	Verified	0.308129902775235	0.378991744165508	no	1904	0.379523142534992	1274	NA	FT		NUCLEUS|MITOCHONDRION		Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress	biological_process	sequence-specific DNA binding	mitochondrion|nucleus|cytoplasm
YKR058W	YKR058W	GLG1	hom	Verified	0.307596273146647	0.379194778202417	no	1905	0.374435151786588	1255	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication	glycogen biosynthetic process	glycogenin glucosyltransferase activity	cellular_component
YKL039W	YKL039W	PTM1	hom	Verified	0.306765710675754	0.379510854776385	no	1906	0.369083585495064	1229	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YLL009C	YLL009C	COX17	hom	Verified	0.30648236048692	0.379618704182174	no	1907	0.37340437919106	1215	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex IV assembly|intracellular copper ion transport	copper chaperone activity	cytosol|mitochondrion|mitochondrial intermembrane space
YOR219C	YOR219C	STE13	hom	Verified	0.306370490251407	0.379661287069957	no	1908	0.392401295144572	1297	NA	FT	PROTEOLYSIS	GOLGI APPARATUS		Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor	peptide pheromone maturation	aminopeptidase activity	trans-Golgi network
YOR111W_p	YOR111W	YOR111W	hom	Uncharacterized	0.306310201436487	0.379684236333788	no	1909	0.36551843661925	1235	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR365C_p	YOR365C	YOR365C	hom	Uncharacterized	0.305795737087598	0.379880087204701	no	1910	0.363584792278794	1198	NA					Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YGL109W_d	YGL109W	YGL109W	hom	Dubious	0.304827593317969	0.380248732316097	no	1911	0.363986752476668	1210	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C	Unknown	Unknown	Unknown
YLL017W	YLL017W	YLL017W	hom	pseudogene	0.30377562084181	0.380649420657053	no	1912	0.347322082096747	1153	NA	FT	SIGNALING			Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication	Ras protein signal transduction	Ras guanyl-nucleotide exchange factor activity	membrane
YDR007W	YDR007W	TRP1	hom	Verified	0.303725974378344	0.380668333786334	no	1913	0.458877872407063	1505	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)	tryptophan biosynthetic process	phosphoribosylanthranilate isomerase activity	cytoplasm
YPR061C	YPR061C	JID1	hom	Verified	0.303636329027539	0.3807024854631	no	1914	0.371761217158419	1235	NA	FT		MITOCHONDRION		Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae	biological_process	molecular_function	mitochondrion
YOR213C	YOR213C	SAS5	hom	Verified	0.303095168590615	0.380908667995912	no	1915	0.405697011824009	1344	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity	chromatin silencing at telomere	acetyltransferase activity|histone acetyltransferase activity	nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YFL007W	YFL007W	BLM10	hom	Verified	0.302203669827643	0.381248403420246	no	1916	0.388255054772117	1253	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200	proteasome assembly|regulation of proteasomal protein catabolic process	proteasome binding|peptidase activator activity	proteasome core complex|proteasome complex|integral to membrane|nucleus
YBR266C_d	YBR266C	SLM6	hom	Dubious	0.301925937899597	0.381354261174496	no	1917	0.388872605671602	1262	NA					Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase	Unknown	Unknown	Unknown
YJL123C	YJL123C	MTC1	hom	Verified	0.300657449236469	0.381837859427041	no	1918	0.378131488286354	1264	NA	FT		GOLGI APPARATUS		Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1	biological_process	molecular_function	COPI-coated vesicle|ribosome|Golgi apparatus|cytoplasm
YBR287W_p	YBR287W	YBR287W	hom	Uncharacterized	0.300032027919823	0.382076362811358	no	1919	0.36212260685225	1216	NA	FT		ENDOPLASMIC RETICULUM		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YMR193C-A_d	YMR193C-A	YMR193C-A	hom	Dubious	0.299641623007035	0.382225265774321	no	1920	0.358062519629919	1186	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR078W	YOR078W	BUD21	hom	Verified	0.298452398399871	0.382678951007658	no	1921	0.371417682521957	1235	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|90S preribosome
YML073C	YML073C	RPL6A	hom	Verified	0.298108324184661	0.382810244241945	no	1922	0.354236308897917	1161	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YDR332W	YDR332W	IRC3	hom	Verified	0.297803590227118	0.382926537107524	no	1923	0.380167713928799	1268	NA	FT		MITOCHONDRION		Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	ATP-dependent RNA helicase activity	mitochondrion
YNL327W	YNL327W	EGT2	hom	Verified	0.296941837014227	0.38325545728738	no	1924	0.392205455605856	1264	NA	FT	CELL CYCLE|CELL DIVISION			Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner	cytokinesis	cellulase activity	fungal-type cell wall|cellular bud|cell septum
YOR215C	YOR215C	AIM41	hom	Verified	0.296253881996499	0.38351810135441	no	1925	0.383393631619162	1266	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YEL011W	YEL011W	GLC3	hom	Verified	0.295704743136668	0.383727787301314	no	1926	0.359754393978793	1190	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	glycogen biosynthetic process	1,4-alpha-glucan branching enzyme activity	cytoplasm
YEL040W	YEL040W	UTR2	hom	Verified	0.295329006436341	0.383871280118973	no	1927	0.376124978068284	1265	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|CYTOSKELETON		Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck	cell wall chitin metabolic process|fungal-type cell wall organization	transferase activity, transferring glycosyl groups	cellular bud neck septin ring|fungal-type cell wall
YPL206C	YPL206C	PGC1	hom	Verified	0.29452758112834	0.38417739543189	no	1928	0.35120962079363	1178	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs	glycerophospholipid catabolic process|phosphatidylglycerol catabolic process	phosphatidylglycerol phospholipase C activity	mitochondrion|lipid particle
YOR235W_d	YOR235W	IRC13	hom	Dubious	0.294189018285452	0.384306735844266	no	1929	0.406484345147847	1343	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci	Unknown	Unknown	Unknown
YER186C_p	YER186C	YER186C	hom	Uncharacterized	0.294122238708291	0.3843322490197	no	1930	0.377613453159348	1264	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKR024C	YKR024C	DBP7	hom	Verified	0.293375479100621	0.384617583062096	no	1931	0.389268479208081	1283	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus
YLR283W_p	YLR283W	YLR283W	hom	Uncharacterized	0.29178788969937	0.38522440256933	no	1932	0.371556948401503	1255	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene	biological_process	molecular_function	mitochondrion
YOR189W	YOR189W	IES4	hom	Verified	0.291629749416299	0.385284863474147	no	1933	0.378356804645769	1247	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses	response to DNA damage stimulus	molecular_function	nucleus|Ino80 complex
YOR125C	YOR125C	CAT5	hom	Verified	0.291296317330337	0.385412351866103	no	1934	0.380458775657539	1267	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation	ubiquinone biosynthetic process	monooxygenase activity	mitochondrion|mitochondrial inner membrane
YMR054W	YMR054W	STV1	hom	Verified	0.290346327484508	0.38577565014708	no	1935	0.389202068393344	1273	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|late endosome|integral to membrane|Golgi apparatus
YAL061W_p	YAL061W	BDH2	hom	Uncharacterized	0.290276136056209	0.385802496966606	no	1936	0.351738723445685	1178	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3	biological_process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	nucleus|cytoplasm
YCL011C	YCL011C	GBP2	hom	Verified	0.29022736817917	0.385821150027686	no	1937	0.40354792766174	1337	NA	FT	RNA LOCALIZATION	NUCLEUS|CHROMOSOME		Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication	poly(A)+ mRNA export from nucleus|telomere maintenance	RNA binding|telomeric DNA binding	nucleus|cytoplasmic stress granule
YNL092W_p	YNL092W	YNL092W	hom	Uncharacterized	0.290210535119705	0.385827588509215	no	1938	0.375348221098243	1246	NA					Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YBR065C	YBR065C	ECM2	hom	Verified	0.289721525389869	0.386014643696972	no	1939	0.371776922317014	1221	NA	FT	RNA PROCESSING	NUCLEUS		Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p	mRNA splicing, via spliceosome	molecular_function	nucleus
YOR208W	YOR208W	PTP2	hom	Verified	0.288674228904512	0.386415342914833	no	1940	0.381298791367377	1241	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus	inactivation of MAPK activity involved in osmosensory signaling pathway|inactivation of MAPK activity involved in cell wall biogenesis|regulation of sporulation|regulation of protein localization|protein dephosphorylation	protein tyrosine phosphatase activity	nucleus
YLR396C	YLR396C	VPS33	hom	Verified	0.287931723074023	0.386699501609435	no	1941	0.407463433714069	1376	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole	regulation of SNARE complex assembly|endocytosis|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle fusion with vacuole|Golgi to vacuole transport|vacuole organization|vacuole fusion, non-autophagic|vesicle docking|protein targeting to vacuole	phosphatidylinositol binding|ATP binding	cytosol|fungal-type vacuole membrane|HOPS complex|fungal-type vacuole|CORVET complex
YHR114W	YHR114W	BZZ1	hom	Verified	0.287740366940896	0.386772743895614	no	1942	0.36610110109938	1219	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins	response to salt stress|actin filament organization|endocytosis	molecular_function	mating projection tip|cytoplasm|actin cortical patch
YEL044W	YEL044W	IES6	hom	Verified	0.286913127240142	0.387089419401096	no	1943	0.406064123697715	1347	NA	FT		NUCLEUS		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes	biological_process	molecular_function	nucleus
YBR026C	YBR026C	ETR1	hom	Verified	0.286905590095492	0.387092305040175	no	1944	0.414757822490502	1337	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis	fatty acid biosynthetic process|aerobic respiration	enoyl-[acyl-carrier-protein] reductase activity	mitochondrion
YDR186C	YDR186C	YDR186C	hom	Verified	0.285477479193995	0.387639177927279	no	1945	0.369465122248939	1237	NA					Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	ribosome|cytoplasm
YDR282C_p	YDR282C	YDR282C	hom	Uncharacterized	0.283424139550386	0.388425863006525	no	1946	0.373561323166008	1222	NA					Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation	biological_process	molecular_function	cellular_component
YLL056C_p	YLL056C	YLL056C	hom	Uncharacterized	0.281671402931504	0.389097742067269	no	1947	0.35281169838431	1161	NA					Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin	biological_process	molecular_function	cellular_component
YLR247C	YLR247C	IRC20	hom	Verified	0.281381668911359	0.389208838234598	no	1948	0.371475694610211	1239	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci	double-strand break repair via synthesis-dependent strand annealing	helicase activity	mitochondrion|nucleus
YOR015W_d	YOR015W	YOR015W	hom	Dubious	0.28036620092493	0.389598282670092	no	1949	0.383576140444816	1252	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR127C	YJR127C	RSF2	hom	Verified	0.280307546464316	0.389620780766742	no	1950	0.35571766526132	1200	NA	FT		NUCLEUS		Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YPL152W	YPL152W	RRD2	hom	Verified	0.2799562693204	0.389755527910756	no	1951	0.369146887545711	1214	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION			Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress	mitotic spindle organization in nucleus|response to osmotic stress	peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity	protein phosphatase type 2A complex
YPL261C_d	YPL261C	YPL261C	hom	Dubious	0.278950184971894	0.390141527215164	no	1952	0.392251699415943	1319	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W	Unknown	Unknown	Unknown
YML060W	YML060W	OGG1	hom	Verified	0.278827165202421	0.390188733030419	no	1953	0.389491463580044	1284	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance	DNA repair|base-excision repair, AP site formation	oxidized purine nucleobase lesion DNA N-glycosylase activity	mitochondrion
YAL009W	YAL009W	SPO7	hom	Verified	0.278721571931158	0.390229253146421	no	1954	0.408476722057389	1343	NA	FF|FT	CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|integral to membrane
YKL126W	YKL126W	YPK1	hom	Verified	0.278228386002933	0.390418522951992	no	1955	0.477841245745438	1576	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication	eisosome assembly|protein autophosphorylation|negative regulation of phospholipid translocation|protein phosphorylation	protein serine/threonine kinase activity	cytosol|plasma membrane|cellular bud neck
YOR192C	YOR192C	THI72	hom	Verified	0.277401001173151	0.390736106477926	no	1956	0.412187600867203	1350	NA					Transporter of thiamine or related compound; shares sequence similarity with Thi7p	thiamine transport	transporter activity	integral to membrane|membrane
YFR043C	YFR043C	IRC6	hom	Verified	0.277353566137143	0.390754316161187	no	1957	0.389764981734042	1287	NA					Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YGR059W	YGR059W	SPR3	hom	Verified	0.276253119466535	0.391176830259684	no	1958	0.392039093348095	1299	NA	FT	CELL CYCLE	SITE OF POLARIZED GROWTH|CYTOSKELETON		Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI	ascospore formation	structural molecule activity	septin complex|ascospore wall|prospore membrane
YGL015C_p	YGL015C	YGL015C	hom	Uncharacterized	0.2760293775495	0.391262751210915	no	1959	0.382078121808088	1262	NA					Putative protein of unknown function; null mutants accumulate cargo in the Golgi	biological_process	molecular_function	cellular_component
YJL062W	YJL062W	LAS21	hom	Verified	0.275679053065363	0.391397292819747	no	1960	0.395884447059082	1315	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity	GPI anchor biosynthetic process	mannose-ethanolamine phosphotransferase activity|transferase activity	integral to endoplasmic reticulum membrane|integral to membrane|integral to plasma membrane
YIR043C	YIR043C	YIR043C	hom	pseudogene	0.273215085683834	0.392343942143643	no	1961	0.392818088001706	1307	NA					Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family	biological_process	molecular_function	cellular_component
YLR118C	YLR118C	YLR118C	hom	Verified	0.270961369891538	0.393210371748661	no	1962	0.385611367775265	1277	NA	FT	KETONE METABOLISM|LIPID METABOLISM	NUCLEUS		Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS	protein deacylation	palmitoyl-(protein) hydrolase activity	nucleus|cytoplasm
YJL200C	YJL200C	ACO2	hom	Verified	0.27071008991657	0.393307007930441	no	1963	0.361093794255329	1171	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol	biological_process	aconitate hydratase activity	mitochondrion
YDR020C_p	YDR020C	DAS2	hom	Uncharacterized	0.27020997512167	0.393499359502949	no	1964	0.375171233098466	1245	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases	biological_process	molecular_function	nucleus|cytoplasm
YFL020C	YFL020C	PAU5	hom	Verified	0.269410816243925	0.393806781808071	no	1965	0.385500723498375	1268	NA					Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme	biological_process	molecular_function	integral to membrane|cytoplasm
YGL012W	YGL012W	ERG4	hom	Verified	0.268750123071177	0.394060988795417	no	1966	0.483851258848253	1615	NA	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM		C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol	ergosterol biosynthetic process	delta24(24-1) sterol reductase activity	integral to membrane|endoplasmic reticulum
YOR202W	YOR202W	HIS3	hom	Verified	0.267673783558942	0.394475215665382	no	1967	0.37623339093115	1248	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p	histidine biosynthetic process	imidazoleglycerol-phosphate dehydratase activity	cellular_component
YNL148C	YNL148C	ALF1	hom	Verified	0.267667125728075	0.394477778288697	no	1968	0.41469678877716	1366	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS|CYTOSKELETON		Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance	protein folding|post-chaperonin tubulin folding pathway	microtubule binding|alpha-tubulin binding	nucleus|cytoplasm
YPR073C	YPR073C	LTP1	hom	Verified	0.266720879854101	0.394842038165054	no	1969	0.38148842329896	1258	NA	FT		NUCLEUS		Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine	protein dephosphorylation	protein tyrosine phosphatase activity	nucleus|cytoplasm
YML066C	YML066C	SMA2	hom	Verified	0.265031161148915	0.395492728383823	no	1970	0.367860584119921	1228	NA	FT	MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS	ENDOPLASMIC RETICULUM		Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation	ascospore wall assembly|spore membrane bending pathway	molecular_function	integral to membrane|prospore membrane|cytoplasm
YLR109W	YLR109W	AHP1	hom	Verified	0.263851211672801	0.395947285576419	no	1971	0.397617592255944	1306	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p	cellular response to oxidative stress|response to metal ion|cell redox homeostasis	thioredoxin peroxidase activity	plasma membrane|cytoplasm
YML057C-A_d	YML057C-A	YML057C-A	hom	Dubious	0.26306771115282	0.39624919520351	no	1972	0.373389005358859	1236	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W	Unknown	Unknown	Unknown
YDR210W_p	YDR210W	YDR210W	hom	Uncharacterized	0.262451656737423	0.396486625815949	no	1973	0.359223971346943	1211	NA	FT		PLASMA MEMBRANE		Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YPL112C	YPL112C	PEX25	hom	Verified	0.261468754545768	0.39686552094786	no	1974	0.403625690728216	1345	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p	protein import into peroxisome matrix|peroxisome organization	molecular_function	peroxisomal membrane
YLR412C-A_p	YLR412C-A	YLR412C-A	hom	Uncharacterized	0.261420624015882	0.396884077102056	no	1975	0.400676157427802	1324	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGR150C	YGR150C	CCM1	hom	Verified	0.260121931116687	0.397384860739879	no	1976	0.402547387595084	1305	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport	rRNA metabolic process|mitochondrial RNA processing|mitochondrial genome maintenance	rRNA binding	mitochondrion
YNL239W	YNL239W	LAP3	hom	Verified	0.259744728311785	0.397530344109242	no	1977	0.391430029613296	1299	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS	MITOCHONDRION		Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH	response to antibiotic|negative regulation of transcription from RNA polymerase II promoter|homocysteine catabolic process	double-stranded DNA binding|cysteine-type peptidase activity|mRNA binding|single-stranded DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	mitochondrion|cytoplasm
YKL184W	YKL184W	SPE1	hom	Verified	0.259238869539631	0.397725471178568	no	1978	0.401567569612968	1334	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation	pantothenate biosynthetic process|putrescine biosynthetic process	ornithine decarboxylase activity	cytoplasm
YGL042C_d	YGL042C	YGL042C	hom	Dubious	0.258831511271261	0.397882621830218	no	1979	0.398919967142984	1347	NA					Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1	Unknown	Unknown	Unknown
YMR289W	YMR289W	ABZ2	hom	Verified	0.258214729725076	0.398120595313636	no	1980	0.406112311873772	1326	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis	folic acid biosynthetic process	4-amino-4-deoxychorismate lyase activity	cytoplasm
YPL096W	YPL096W	PNG1	hom	Verified	0.258046391741372	0.398185551925595	no	1981	0.406786269728219	1343	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS|MITOCHONDRION		Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p	misfolded or incompletely synthesized protein catabolic process|protein deglycosylation	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity	cytosol|mitochondrion|nucleus
YLR279W_d	YLR279W	YLR279W	hom	Dubious	0.257747472815346	0.398300902785079	no	1982	0.403301699017435	1346	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL105W	YGL105W	ARC1	hom	Verified	0.256018522414962	0.398968267510787	no	1983	0.407698444284089	1366	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress	positive regulation of ligase activity|tRNA aminoacylation for protein translation	enzyme activator activity|tRNA binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding	methionyl glutamyl tRNA synthetase complex|cytoplasm
YOL072W	YOL072W	THP1	hom	Verified	0.255995188607888	0.398977276248543	no	1984	0.437031337275476	1433	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding	mRNA export from nucleus|mRNA 3'-end processing|transcription-coupled nucleotide-excision repair|cellular bud site selection|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|transcription elongation from RNA polymerase II promoter	double-stranded DNA binding|RNA binding	nuclear envelope|nucleus|transcription export complex 2|nuclear pore
YGR228W_d	YGR228W	YGR228W	hom	Dubious	0.255308672239827	0.399242351184012	no	1985	0.400931725197966	1327	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C	Unknown	Unknown	Unknown
YGL148W	YGL148W	ARO2	hom	Verified	0.254733655034386	0.399464410274499	no	1986	0.455198859147223	1503	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress	aromatic amino acid family biosynthetic process	chorismate synthase activity|riboflavin reductase (NADPH) activity	cytoplasm
YGR236C	YGR236C	SPG1	hom	Verified	0.253929560432516	0.399774988587242	no	1987	0.400044350970364	1336	NA	FT		MITOCHONDRION		Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YMR003W	YMR003W	AIM34	hom	Verified	0.253773910612811	0.399835115037725	no	1988	0.40354887478034	1318	NA	FT		MITOCHONDRION		Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YCL030C	YCL030C	HIS4	hom	Verified	0.253535759106988	0.399927115916341	no	1989	0.40765733914983	1346	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis	histidine biosynthetic process	phosphoribosyl-ATP diphosphatase activity|phosphoribosyl-AMP cyclohydrolase activity|histidinol dehydrogenase activity	intracellular
YER084W_p	YER084W	YER084W	hom	Uncharacterized	0.252658081291185	0.400266221659394	no	1990	0.400757136915681	1338	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YKL218C	YKL218C	SRY1	hom	Verified	0.252657795382567	0.400266332137316	no	1991	0.40100132506034	1319	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity	cellular modified amino acid catabolic process	serine racemase activity|threo-3-hydroxyaspartate ammonia-lyase activity	cellular_component
YOR028C	YOR028C	CIN5	hom	Verified	0.252651569163833	0.400268738011867	no	1992	0.376788195985875	1233	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication	hyperosmotic salinity response|response to drug|hyperosmotic response|regulation of transcription from RNA polymerase II promoter	repressing transcription factor binding|sequence-specific DNA binding	nucleus|cytoplasm
YCR020W-B	YCR020W-B	HTL1	hom	Verified	0.252045643985634	0.400502891785775	no	1993	0.413638413256194	1363	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance	regulation of cell cycle|nucleosome disassembly|response to DNA damage stimulus|chromatin remodeling|transcription elongation from RNA polymerase II promoter	chromatin binding	RSC complex
YER033C	YER033C	ZRG8	hom	Verified	0.25148984847998	0.40071770489415	no	1994	0.403364416511525	1318	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency	fungal-type cell wall organization	molecular_function	mitochondrion|cellular bud|cellular bud neck|mating projection tip|cytoplasm
YLR284C	YLR284C	ECI1	hom	Verified	0.250749708717563	0.401003813051048	no	1995	0.39551935759822	1310	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced	fatty acid beta-oxidation	dodecenoyl-CoA delta-isomerase activity	peroxisome
YGL208W	YGL208W	SIP2	hom	Verified	0.250722423351415	0.401014361488069	no	1996	0.387901038079453	1300	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	PLASMA MEMBRANE		One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane	cellular response to glucose starvation|signal transduction|protein phosphorylation|replicative cell aging|invasive growth in response to glucose limitation|regulation of protein complex assembly	AMP-activated protein kinase activity	AMP-activated protein kinase complex|plasma membrane|cytoplasm
YOR255W	YOR255W	OSW1	hom	Verified	0.250664915235784	0.40103659418162	no	1997	0.400461383766836	1317	NA	FT	CELL WALL ORG/BIOGENESIS			Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p	ascospore wall assembly|ascospore formation	molecular_function	prospore membrane
YNR063W_p	YNR063W	YNR063W	hom	Uncharacterized	0.250524355842945	0.401090935928714	no	1998	0.389671767183594	1280	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc-cluster protein of unknown function	biological_process	sequence-specific DNA binding	cellular_component
YKL085W	YKL085W	MDH1	hom	Verified	0.24975460707238	0.401388562847916	no	1999	0.405098584219736	1312	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated	chronological cell aging|replicative cell aging|tricarboxylic acid cycle|aerobic respiration	L-malate dehydrogenase activity|mRNA binding	mitochondrion|mitochondrial matrix
YKL151C	YKL151C	YKL151C	hom	Verified	0.249750579340081	0.401390120339861	no	2000	0.376718682113374	1255	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	nicotinamide nucleotide metabolic process	ATP-dependent NAD(P)H-hydrate dehydratase activity	cytoplasm
YKR105C_p	YKR105C	VBA5	hom	Uncharacterized	0.249346634615533	0.401546330495936	no	2001	0.395646575833163	1307	NA					Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p	biological_process	molecular_function	integral to membrane
YHR022C-A_p	YHR022C-A	YHR022C-A	hom	Uncharacterized	0.246206494470323	0.402761194207992	no	2002	0.399466801663655	1341	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YPL203W	YPL203W	TPK2	hom	Verified	0.24605831017142	0.402818547351119	no	2003	0.401708128169564	1368	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase	protein phosphorylation|Ras protein signal transduction|invasive growth in response to glucose limitation	cAMP-dependent protein kinase activity|protein kinase activity	nucleus|cAMP-dependent protein kinase complex
YDR439W	YDR439W	LRS4	hom	Verified	0.24542800917958	0.403062521938819	no	2004	0.429805834828695	1441	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME	KINETOCHORE	Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation	rDNA condensation|chromatin silencing at rDNA|homologous chromosome segregation|protein localization to nucleolar rDNA repeats	molecular_function	nucleolus|nucleus|monopolin complex
YMR072W	YMR072W	ABF2	hom	Verified	0.245063974235847	0.403203448445555	no	2005	0.40968118114129	1353	NA	FT	MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation	mitochondrion inheritance|mitochondrial DNA packaging|mitochondrial genome maintenance	DNA binding, bending|DNA binding	mitochondrial nucleoid|mitochondrial chromosome|mitochondrion
YLR418C	YLR418C	CDC73	hom	Verified	0.244795019363627	0.403307575292597	no	2006	0.497812859119971	1688	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress	transcription elongation from RNA polymerase I promoter|negative regulation of DNA recombination|mRNA 3'-end processing|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair|transcription elongation from RNA polymerase II promoter	chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YHR050W-A_p	YHR050W-A	YHR050W-A	hom	Uncharacterized	0.244035700601966	0.403601585261671	no	2007	0.407581675531647	1337	NA					Protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YFL010W-A	YFL010W-A	AUA1	hom	Verified	0.243513320112202	0.403803883832615	no	2008	0.413787344593413	1362	NA					Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease	amino acid transport	molecular_function	cellular_component
YBR033W_p	YBR033W	EDS1	hom	Uncharacterized	0.242212711683145	0.404307672885471	no	2009	0.395137299434024	1285	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication	biological_process	sequence-specific DNA binding	cellular_component
YOR230W	YOR230W	WTM1	hom	Verified	0.240679061032476	0.404901934431108	no	2010	0.38127102567038	1249	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|GENE SILENCING	NUCLEUS		Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats	negative regulation of chromatin silencing at silent mating-type cassette|maintenance of protein location in nucleus|negative regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of chromatin silencing at telomere|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter	protein binding|transcription corepressor activity	nucleus
YDR080W	YDR080W	VPS41	hom	Verified	0.239221211634354	0.405467027794897	no	2011	0.404783187607589	1329	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING			Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole organization|vesicle-mediated transport|protein transport|vacuole fusion, non-autophagic|vacuolar protein processing	Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding	endosome|fungal-type vacuole membrane|HOPS complex
YDR273W	YDR273W	DON1	hom	Verified	0.23878234143246	0.405637181850535	no	2012	0.393840741784125	1344	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION			Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II	meiosis|ascospore wall assembly	molecular_function	prospore membrane
YGR023W	YGR023W	MTL1	hom	Verified	0.238718353162551	0.405661992187672	no	2013	0.403442664701327	1322	NA	FT	CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	PLASMA MEMBRANE		Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p	cellular response to glucose starvation|fungal-type cell wall organization|cellular response to oxidative stress	molecular_function	integral to plasma membrane
YNL301C	YNL301C	RPL18B	hom	Verified	0.238703439386276	0.405667774799123	no	2014	0.394772958541255	1311	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YHR006W	YHR006W	STP2	hom	Verified	0.238701418972838	0.405668558188204	no	2015	0.381544772513682	1277	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|PLASMA MEMBRANE		Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YPL091W	YPL091W	GLR1	hom	Verified	0.238380438013913	0.405793019183851	no	2016	0.407321619805763	1356	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress|protein glutathionylation	glutathione-disulfide reductase activity	mitochondrion|nucleus|cytoplasm
YEL049W	YEL049W	PAU2	hom	Verified	0.236520232315627	0.406514504734344	no	2017	0.384330325709828	1278	NA					Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YDL067C	YDL067C	COX9	hom	Verified	0.236255114978768	0.406617357078363	no	2018	0.413881588419323	1360	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YJR020W_d	YJR020W	YJR020W	hom	Dubious	0.235123948207612	0.407056265839748	no	2019	0.405630708199391	1333	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR150C	YJR150C	DAN1	hom	Verified	0.233515299463694	0.407680645328096	no	2020	0.37539599135945	1261	NA					Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth	sterol transport	molecular_function	fungal-type cell wall
YJL029C	YJL029C	VPS53	hom	Verified	0.232908586732059	0.407916195271972	no	2021	0.364307595673836	1223	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting	Golgi to vacuole transport|retrograde transport, endosome to Golgi	molecular_function	Golgi apparatus|GARP complex|cytoplasm
YPL120W	YPL120W	VPS30	hom	Verified	0.232452467272175	0.40809330085932	no	2022	0.406284851307069	1363	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1	phosphatidylinositol biosynthetic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|retrograde transport, endosome to Golgi|macroautophagy|CVT pathway|late endosome to vacuole transport	1-phosphatidylinositol-3-kinase activity	phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|extrinsic to membrane|cytoplasm
YPL089C	YPL089C	RLM1	hom	Verified	0.230931000463426	0.408684203342095	no	2023	0.444335843827606	1449	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication	signal transduction|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|DNA binding, bending|sequence-specific DNA binding	nucleus
YML055W	YML055W	SPC2	hom	Verified	0.230644020505577	0.408795683030339	no	2024	0.420340725828032	1387	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25	signal peptide processing|protein targeting to ER	peptidase activity	signal peptidase complex
YOR131C	YOR131C	YOR131C	hom	Verified	0.2294593074755	0.409255972412291	no	2025	0.415740782585535	1377	NA	FT		NUCLEUS		Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YKL075C_p	YKL075C	YKL075C	hom	Uncharacterized	0.22904648442573	0.409416393485377	no	2026	0.415679628828082	1392	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin	response to drug	molecular_function	cytoplasm
YOL087C	YOL087C	DUF1	hom	Verified	0.228713646194073	0.409545743885427	no	2027	0.459577218939886	1512	NA					Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid	biological_process	ubiquitin binding	cytoplasm
YKL146W	YKL146W	AVT3	hom	Verified	0.226835091961509	0.410275987706992	no	2028	0.408891537687949	1358	NA	FT	VACUOLAR TRANSPORT			Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid export from vacuole	transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YLR107W	YLR107W	REX3	hom	Verified	0.226594033575049	0.410369716074311	no	2029	0.407669553001494	1339	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases	U5 snRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing	3'-5'-exoribonuclease activity|3'-5' exonuclease activity	nucleus|cytoplasm
YCR087W_d	YCR087W	YCR087W	hom	Dubious	0.225990617035234	0.410604359044137	no	2030	0.438317542557451	1432	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene	Unknown	Unknown	Unknown
YLR016C	YLR016C	PML1	hom	Verified	0.225229371768275	0.410900420516787	no	2031	0.387279783713083	1265	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p	mRNA export from nucleus|mRNA splicing, via spliceosome|maintenance of RNA location	molecular_function	RES complex|nucleus|cytoplasm
YIL112W	YIL112W	HOS4	hom	Verified	0.224804573270996	0.41106565409083	no	2032	0.400348892915151	1316	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate	negative regulation of meiosis|histone deacetylation	molecular_function	Set3 complex
YBR168W	YBR168W	PEX32	hom	Verified	0.223314178726756	0.411645496428846	no	2033	0.417092201486156	1390	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p	peroxisome organization	molecular_function	integral to membrane|integral to peroxisomal membrane
YHR079C	YHR079C	IRE1	hom	Verified	0.221795774198071	0.41223643461921	no	2034	0.432540164203706	1431	NA	FF|FT	RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress	endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|inositol metabolic process|protein phosphorylation	unfolded protein binding|protein serine/threonine kinase activity|endoribonuclease activity|protein kinase activity|protein homodimerization activity	nucleus
YIR028W	YIR028W	DAL4	hom	Verified	0.221315268772947	0.412423480988835	no	2035	0.412346158616896	1369	NA					Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process|allantoin transport	allantoin uptake transmembrane transporter activity	integral to membrane|membrane
YOR242C	YOR242C	SSP2	hom	Verified	0.220970797798074	0.412557585465867	no	2036	0.406563440196582	1333	NA	FT	CELL WALL ORG/BIOGENESIS			Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis	ascospore wall assembly|ascospore formation	molecular_function	ascospore wall
YKL136W_d	YKL136W	YKL136W	hom	Dubious	0.219394762800034	0.413171274669507	no	2037	0.428668713767795	1416	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C	Unknown	Unknown	Unknown
YOR044W	YOR044W	IRC23	hom	Verified	0.217863879450512	0.413767585574781	no	2038	0.406503650061342	1336	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication	biological_process	molecular_function	endoplasmic reticulum
YJL188C_d	YJL188C	BUD19	hom	Dubious	0.217533073146007	0.413896467692505	no	2039	0.369567821999757	1200	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YBL012C_d	YBL012C	YBL012C	hom	Dubious	0.217037371071665	0.414089610550674	no	2040	0.413552899711764	1365	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR021C	YCR021C	HSP30	hom	Verified	0.216947192326909	0.414124749577736	no	2041	0.406873714735749	1344	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	PLASMA MEMBRANE		Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase	negative regulation of ATPase activity|response to stress	molecular_function	integral to membrane|plasma membrane
YKL117W	YKL117W	SBA1	hom	Verified	0.216570652454011	0.414271479435183	no	2042	0.40413179582699	1305	NA	FT		NUCLEUS		Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress	protein folding|positive regulation of telomere maintenance via telomerase|regulation of telomerase activity	chaperone binding	nucleus|cytoplasm
YML057W	YML057W	CMP2	hom	Verified	0.216162641058025	0.414430486606309	no	2043	0.391767551310161	1273	NA	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS			Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity	calcineurin complex|cytoplasm
YEL066W	YEL066W	HPA3	hom	Verified	0.215468538319594	0.41470101938008	no	2044	0.373024036330901	1287	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro	D-amino acid metabolic process	D-amino-acid N-acetyltransferase activity	nucleus|cytoplasm
YEL065W	YEL065W	SIT1	hom	Verified	0.215274109101492	0.414776807173376	no	2045	0.406872706992352	1361	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p	cellular iron ion homeostasis|siderophore transport|transmembrane transport	siderophore uptake transmembrane transporter activity	endosome|integral to membrane|cytoplasmic membrane-bounded vesicle
YOR248W_d	YOR248W	YOR248W	hom	Dubious	0.213332020555215	0.41553399978234	no	2046	0.416722280901633	1366	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR078C	YGR078C	PAC10	hom	Verified	0.212071874468989	0.416025480781057	no	2047	0.434028116557163	1427	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding	tubulin complex assembly	tubulin binding	prefoldin complex|polysome|cytoplasm
YDR400W	YDR400W	URH1	hom	Verified	0.211757085769552	0.416148274910376	no	2048	0.412383945575723	1346	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways	pyrimidine-containing compound salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|pyrimidine nucleoside catabolic process|nicotinate nucleotide salvage	ribosylpyrimidine nucleosidase activity|nicotinic acid riboside hydrolase activity|nicotinamide riboside hydrolase activity|uridine nucleosidase activity	nucleus|cytoplasm
YDR524C	YDR524C	AGE1	hom	Verified	0.211294946374064	0.416328563059242	no	2049	0.36615696789176	1231	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	GOLGI APPARATUS		ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport	phospholipid binding|ARF GTPase activator activity	endosome|trans-Golgi network|cytoplasm
YGL246C	YGL246C	RAI1	hom	Verified	0.210732090357987	0.416548166187119	no	2050	0.404214642555491	1330	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z	deadenylation-dependent decapping of nuclear-transcribed mRNA|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|termination of RNA polymerase II transcription, poly(A)-coupled|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	enzyme regulator activity|m7G(5')pppN diphosphatase activity	nucleus
YNL082W	YNL082W	PMS1	hom	Verified	0.210701224655452	0.41656020946111	no	2051	0.41707816439988	1374	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL	mismatch repair|meiotic mismatch repair	double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding	nucleus|MutLalpha complex|cytoplasm
YER087W	YER087W	AIM10	hom	Verified	0.209014195724316	0.41721857838975	no	2052	0.424932748371673	1407	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	proline-tRNA ligase activity	mitochondrion
YPL053C	YPL053C	KTR6	hom	Verified	0.208748475896439	0.417322297691936	no	2053	0.421111230085967	1386	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication	fungal-type cell wall organization|protein N-linked glycosylation	mannosylphosphate transferase activity	membrane
YHR207C	YHR207C	SET5	hom	Verified	0.208663265720034	0.417355559281488	no	2054	0.422527284091212	1389	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus	histone lysine methylation	S-adenosylmethionine-dependent methyltransferase activity	nuclear chromatin|nucleus|cytoplasm
YPR128C	YPR128C	ANT1	hom	Verified	0.207856184444808	0.417670630832872	no	2055	0.413342960247331	1379	NA	FT	KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|PEROXISOME ORGANIZATION			Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation	ATP transport|fatty acid beta-oxidation|peroxisome organization	adenine nucleotide transmembrane transporter activity	integral to membrane|cytoplasm|integral to peroxisomal membrane
YDR110W	YDR110W	FOB1	hom	Verified	0.205765910891051	0.418486885265594	no	2056	0.417584190820131	1358	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases	extrachromosomal circular DNA accumulation involved in cell aging|negative regulation of DNA replication|rDNA condensation|chromatin silencing at rDNA|replicative cell aging|protein localization to nucleolar rDNA repeats|DNA recombination	rDNA spacer replication fork barrier binding	nucleolus|rDNA heterochromatin
YNR001C	YNR001C	CIT1	hom	Verified	0.205467127894381	0.418603589162701	no	2057	0.427686175217731	1418	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication	glutamate biosynthetic process|tricarboxylic acid cycle|acetyl-CoA catabolic process|citrate metabolic process	citrate (Si)-synthase activity	mitochondrion
YEL064C	YEL064C	AVT2	hom	Verified	0.204376139065983	0.419029787461179	no	2058	0.405740099835665	1353	NA	FT		ENDOPLASMIC RETICULUM		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	transport	transporter activity	integral to membrane|endoplasmic reticulum
YGR035W-A_p	YGR035W-A	YGR035W-A	hom	Uncharacterized	0.203222261357423	0.419480656909618	no	2059	0.408114174082839	1354	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDL112W	YDL112W	TRM3	hom	Verified	0.202842447318335	0.419629089683513	no	2060	0.435695122027862	1444	NA	FT	RNA PROCESSING			2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs	tRNA methylation	tRNA (guanine) methyltransferase activity	cytoplasm
YBR086C	YBR086C	IST2	hom	Verified	0.202761007943139	0.419660917991338	no	2061	0.430842609855931	1430	NA	FT		PLASMA MEMBRANE		Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process	response to osmotic stress	lipid binding	integral to membrane|cellular bud membrane|plasma membrane
YBL003C	YBL003C	HTA2	hom	Verified	0.201254481262463	0.420249796491275	no	2062	0.420990135355563	1396	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p	DNA repair|chromatin assembly or disassembly	DNA binding	replication fork protection complex|nuclear nucleosome
YEL050C	YEL050C	RML2	hom	Verified	0.200624000132512	0.42049629510951	no	2063	0.43565193544026	1422	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM|TRANSLATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor	cytoplasmic translation|fatty acid metabolic process	structural constituent of ribosome	mitochondrial large ribosomal subunit
YBR056W-A_p	YBR056W-A	YBR056W-A	hom	Uncharacterized	0.200541701751514	0.420528473533386	no	2064	0.447876734702117	1466	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B	biological_process	molecular_function	cellular_component
YHR112C	YHR112C	YHR112C	hom	Verified	0.199581933540944	0.420903779225362	no	2065	0.421848111314227	1393	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway	sulfur compound metabolic process	cystathionine beta-lyase activity	nucleus|cytoplasm
YPL041C_p	YPL041C	YPL041C	hom	Uncharacterized	0.19750516029583	0.421716121821691	no	2066	0.411831135677329	1338	NA					Protein of unknown function involved in maintenance of proper telomere length	biological_process	molecular_function	cellular_component
YOR029W_d	YOR029W	YOR029W	hom	Dubious	0.19707778942058	0.421883332019924	no	2067	0.385838511282272	1275	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR443W	YLR443W	ECM7	hom	Verified	0.196850167046685	0.421972395739278	no	2068	0.42201777618464	1416	NA	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency	fungal-type cell wall organization|calcium ion transport	molecular_function	integral to membrane
YGL035C	YGL035C	MIG1	hom	Verified	0.195851863337315	0.422363057496406	no	2069	0.437657013134226	1432	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|NUCLEUS		Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion	negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus|nuclear envelope lumen|cytoplasm
YDL046W	YDL046W	NPC2	hom	Verified	0.195790509674047	0.422387069248436	no	2070	0.414469453854567	1353	NA					Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes	intracellular sterol transport	molecular_function	fungal-type vacuole lumen|fungal-type vacuole
YPL135W	YPL135W	ISU1	hom	Verified	0.195457577835108	0.422517372554988	no	2071	0.428109572748945	1399	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable	cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification	ferrous iron binding	mitochondrion|mitochondrial matrix
YJL210W	YJL210W	PEX2	hom	Verified	0.195439673777942	0.422524380109118	no	2072	0.41779637885822	1394	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import	protein import into peroxisome matrix	ubiquitin-protein ligase activity|protein binding	peroxisomal membrane
YGL077C	YGL077C	HNM1	hom	Verified	0.194912289179287	0.422730806666511	no	2073	0.414661966410937	1371	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol	choline transport|ethanolamine transport|glycine betaine transport	choline transmembrane transporter activity|ethanolamine transmembrane transporter activity	integral to membrane|plasma membrane
YCL005W-A	YCL005W-A	VMA9	hom	Verified	0.194853791706499	0.422753704798164	no	2074	0.443873500732315	1451	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis	cell wall mannoprotein biosynthetic process|vacuolar acidification|protein complex assembly|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions	vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane
YER161C	YER161C	SPT2	hom	Verified	0.194567366907109	0.422865826104791	no	2075	0.427711939425784	1400	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION	NUCLEUS		Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins	negative regulation of transcription from RNA polymerase II promoter|chromatin organization|RNA polyadenylation|transcription elongation from RNA polymerase II promoter	DNA binding|DNA secondary structure binding	nucleus
YKL066W_d	YKL066W	YKL066W	hom	Dubious	0.194216069638937	0.423003350342343	no	2076	0.38966113525097	1291	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene YNK1	Unknown	Unknown	Unknown
YDR476C_p	YDR476C	YDR476C	hom	Uncharacterized	0.19374723093384	0.423186903775611	no	2077	0.421275029083553	1357	NA	FT		ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YNL333W	YNL333W	SNZ2	hom	Verified	0.193256329790713	0.423379112667141	no	2078	0.420170671159167	1411	NA	FT	COFACTOR METABOLISM			Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p	pyridoxine metabolic process|thiamine biosynthetic process	protein binding	cellular_component
YBR020W	YBR020W	GAL1	hom	Verified	0.192983182758305	0.423486069366548	no	2079	0.411535820654003	1350	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS			Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication	galactose catabolic process via UDP-galactose|carbohydrate phosphorylation|positive regulation of transcription by galactose	galactokinase activity	cytoplasm
YBR037C	YBR037C	SCO1	hom	Verified	0.192443367625573	0.423697462371988	no	2080	0.430968344762078	1418	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication	copper ion transport|response to redox state|protein complex assembly	copper ion binding|thioredoxin peroxidase activity	mitochondrion|mitochondrial inner membrane
YJL175W_d	YJL175W	YJL175W	hom	Dubious	0.191269631055789	0.424157176364935	no	2081	0.422917266360873	1400	NA					Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor	Unknown	Unknown	Unknown
YKL006W	YKL006W	RPL14A	hom	Verified	0.190317405124584	0.424530207794046	no	2082	0.437435796509608	1437	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YOL030W	YOL030W	GAS5	hom	Verified	0.189312031892393	0.424924132874222	no	2083	0.426770826177094	1404	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall	(1->3)-beta-D-glucan metabolic process	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane
YBR196C-B_p	YBR196C-B	YBR196C-B	hom	Uncharacterized	0.187207476485048	0.425748981542536	no	2084	0.42345771202271	1390	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YPL058C	YPL058C	PDR12	hom	Verified	0.186968741867248	0.425842570559215	no	2085	0.42724023737153	1387	NA	FT	KETONE METABOLISM|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity	propionate metabolic process|transport|organic acid transport	xenobiotic-transporting ATPase activity|organic acid transmembrane transporter activity	integral to membrane|plasma membrane
YBR279W	YBR279W	PAF1	hom	Verified	0.186950061240795	0.425849893935964	no	2086	0.49180810317344	1710	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1	negative regulation of DNA recombination|mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of transcription-coupled nucleotide-excision repair|rRNA processing|transcription elongation from RNA polymerase I promoter|regulation of chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin silencing at rDNA|Unknown|snoRNA 3'-end processing|transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity	transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YDR131C_p	YDR131C	YDR131C	hom	Uncharacterized	0.186322513817894	0.426095926559107	no	2087	0.416844583503067	1390	NA	FT	PROTEOLYSIS			F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YOR231W	YOR231W	MKK1	hom	Verified	0.186065850869017	0.426196560649257	no	2088	0.430371304906367	1433	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH		MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication	signal transduction|peroxisome degradation|protein phosphorylation	protein kinase activity|MAP kinase kinase activity	cellular bud tip
YDR137W	YDR137W	RGP1	hom	Verified	0.185646214779807	0.426361104665222	no	2089	0.449502945384928	1496	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL DIVISION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p	retrograde transport, endosome to Golgi	guanyl-nucleotide exchange factor activity	Golgi apparatus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YLL033W	YLL033W	IRC19	hom	Verified	0.184957581535411	0.426631153247983	no	2090	0.404126062119378	1355	NA					Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci	mitotic recombination|ascospore formation	molecular_function	cellular_component
YDL216C	YDL216C	RRI1	hom	Verified	0.184766229189645	0.426706198476159	no	2091	0.420887789502284	1407	NA	FT	SIGNALING|PROTEOLYSIS	NUCLEUS		Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	metalloendopeptidase activity	signalosome
YBR171W	YBR171W	SEC66	hom	Verified	0.184709464290182	0.426728461242188	no	2092	0.470340452150931	1827	NA	FF|FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	posttranslational protein targeting to membrane, translocation|filamentous growth	protein transporter activity	integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YNL043C_d	YNL043C	YNL043C	hom	Dubious	0.184174140073492	0.426938422839051	no	2093	0.430811580346317	1440	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W	Unknown	Unknown	Unknown
YGL250W	YGL250W	RMR1	hom	Verified	0.183216830870025	0.427313944385443	no	2094	0.42308445892988	1426	NA	FT	CELL CYCLE	NUCLEUS		Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus	meiotic gene conversion|reciprocal meiotic recombination	molecular_function	nucleus|cytoplasm
YER057C	YER057C	HMF1	hom	Verified	0.182999136903747	0.427399347916747	no	2095	0.41568103424867	1367	NA	FT		NUCLEUS		Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro	biological_process	molecular_function	cytosol|nucleus|cytoplasm
YOR114W_p	YOR114W	YOR114W	hom	Uncharacterized	0.182155372994456	0.427730397094709	no	2096	0.43512584379076	1450	NA					Putative protein of unknown function; null mutant is viable	biological_process	molecular_function	cellular_component
YKL041W	YKL041W	VPS24	hom	Verified	0.182028588535566	0.427780145140982	no	2097	0.438916483508191	1436	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway	intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	molecular_function	ESCRT III complex|cytoplasm
YJL062W-A	YJL062W-A	COA3	hom	Verified	0.181887243965134	0.427835607678631	no	2098	0.42492462818717	1414	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly	mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation	molecular_function	mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YHR001W	YHR001W	OSH7	hom	Verified	0.18127629663782	0.428075355165214	no	2099	0.421462093449623	1422	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	maintenance of cell polarity|endocytosis|exocytosis|sterol transport|sterol metabolic process|late endosome to vacuole transport	lipid binding|oxysterol binding	integral to membrane|cortical endoplasmic reticulum|cytoplasm
YHR011W	YHR011W	DIA4	hom	Verified	0.179856025089456	0.428632799516381	no	2100	0.427316442571381	1436	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth	pseudohyphal growth|invasive growth in response to glucose limitation|mitochondrial seryl-tRNA aminoacylation	serine-tRNA ligase activity	mitochondrion|cytoplasm
YBR098W	YBR098W	MMS4	hom	Verified	0.179685035887255	0.428699920932032	no	2101	0.423053590685942	1414	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	transcription coactivator activity|endonuclease activity|crossover junction endodeoxyribonuclease activity	Holliday junction resolvase complex|nucleus
YPR038W_d	YPR038W	IRC16	hom	Dubious	0.179618643123596	0.428725983813716	no	2102	0.421298990295096	1395	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci	Unknown	Unknown	Unknown
YKL162C-A_d	YKL162C-A	YKL162C-A	hom	Dubious	0.178615806831951	0.429119691016164	no	2103	0.42715849681668	1412	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR179C	YOR179C	SYC1	hom	Verified	0.177627853657641	0.429507624168278	no	2104	0.430331098772824	1432	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication	termination of RNA polymerase II transcription, exosome-dependent|termination of RNA polymerase II transcription, poly(A)-coupled	RNA binding	mRNA cleavage and polyadenylation specificity factor complex|nucleus
YPL055C	YPL055C	LGE1	hom	Verified	0.176559943582736	0.429927030037521	no	2105	0.448880153948369	1467	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division	histone methylation|protein monoubiquitination|regulation of cell size|histone ubiquitination|premeiotic DNA replication	molecular_function	nucleus
YDL021W	YDL021W	GPM2	hom	Verified	0.175701667988555	0.430264162413382	no	2106	0.437173751515168	1443	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event	biological_process	phosphoglycerate mutase activity|molecular_function	cytosol|cytoplasm
YGR141W	YGR141W	VPS62	hom	Verified	0.174098833229511	0.430893895072786	no	2107	0.415662054762519	1380	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT			Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins	protein targeting to vacuole	molecular_function	cellular_component
YJL160C_p	YJL160C	YJL160C	hom	Uncharacterized	0.173142805510608	0.431269589546325	no	2108	0.451113782222443	1503	NA					Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YKL096W-A	YKL096W-A	CWP2	hom	Verified	0.173039802084582	0.431310070979008	no	2109	0.432802118125817	1446	NA	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored	fungal-type cell wall organization|regulation of pH	structural constituent of cell wall	fungal-type cell wall
YBR239C_p	YBR239C	ERT1	hom	Uncharacterized	0.172628041987148	0.431471904242842	no	2110	0.442575014364929	1461	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM	NUCLEUS		Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition	biological_process	sequence-specific DNA binding	nucleus|cytoplasm
YJR040W	YJR040W	GEF1	hom	Verified	0.170526994270772	0.432297853448912	no	2111	0.427269277508869	1414	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE		Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism	cellular copper ion homeostasis|cellular iron ion homeostasis	voltage-gated chloride channel activity	endosome|integral to membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|fungal-type vacuole|Golgi medial cisterna
YKL040C	YKL040C	NFU1	hom	Verified	0.170012252472955	0.432500250424637	no	2112	0.423706497142444	1395	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria	cellular iron ion homeostasis|iron-sulfur cluster assembly|intracellular sequestering of iron ion	molecular_function	mitochondrion|mitochondrial matrix
YNR040W_p	YNR040W	YNR040W	hom	Uncharacterized	0.169378098739483	0.432749624637468	no	2113	0.435604592592965	1422	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPR133W-A	YPR133W-A	TOM5	hom	Verified	0.16921080286748	0.432815416429776	no	2114	0.432553674948231	1428	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore	mitochondrial outer membrane translocase complex assembly|protein targeting to mitochondrion	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YKL001C	YKL001C	MET14	hom	Verified	0.168659749782688	0.433032140079389	no	2115	0.422945143832347	1390	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process	adenylylsulfate kinase activity	cytoplasm
YMR022W	YMR022W	UBC7	hom	Verified	0.16861704742569	0.433048935329748	no	2116	0.446409008865277	1483	NA	FT	CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly	fungal-type cell wall organization|chromatin assembly or disassembly|ER-associated protein catabolic process	ubiquitin-protein ligase activity	endoplasmic reticulum membrane
YNR005C_d	YNR005C	YNR005C	hom	Dubious	0.168461207164825	0.433110229838616	no	2117	0.42881817952447	1431	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL038C	YGL038C	OCH1	hom	Verified	0.167326994566477	0.433556382482071	no	2118	0.469160487503208	1794	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups	Golgi cis cisterna
YLL057C	YLL057C	JLP1	hom	Verified	0.166817114338499	0.433756976042129	no	2119	0.423517092890213	1403	NA	FT	OXIDATION-REDUCTION PROCESS			Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation	sulfur compound catabolic process	sulfonate dioxygenase activity	cellular_component
YOL001W	YOL001W	PHO80	hom	Verified	0.166513288926587	0.433876513054677	no	2120	0.444993716175309	1476	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling	negative regulation of phosphate metabolic process|regulation of cyclin-dependent protein kinase activity|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|cellular metal ion homeostasis|regulation of protein localization|negative regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YBR169C	YBR169C	SSE2	hom	Verified	0.165699517331742	0.434196712959076	no	2121	0.39297928113224	1264	NA					Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication	protein folding|protein refolding	adenyl-nucleotide exchange factor activity	cytoplasm
YEL059W_d	YEL059W	HHY1	hom	Dubious	0.16201715905995	0.435646170709314	no	2122	0.429607132033502	1408	NA					Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking	Unknown	Unknown	Unknown
YLR068W	YLR068W	FYV7	hom	Verified	0.161845595562759	0.435713723138443	no	2123	0.443701378276967	1458	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|nucleus
YMR190C	YMR190C	SGS1	hom	Verified	0.161492296366788	0.4358528391661	no	2124	0.407860099996406	1350	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes; forms nuclear foci upon DNA replication stress	DNA double-strand break processing|meiotic DNA double-strand break processing|telomeric 3' overhang formation|meiotic chromosome segregation|DNA unwinding involved in replication|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint|telomere maintenance via recombination|replicative cell aging|DNA duplex unwinding|response to DNA damage stimulus|negative regulation of meiotic joint molecule formation|chromosome organization|regulation of reciprocal meiotic recombination|gene conversion at mating-type locus, DNA double-strand break processing|mitotic sister chromatid segregation	ATP-dependent DNA helicase activity	RecQ helicase-Topo III complex|nucleolus
YGR084C	YGR084C	MRP13	hom	Verified	0.160811754468654	0.436120833503231	no	2125	0.431299056205896	1445	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YPL224C	YPL224C	MMT2	hom	Verified	0.16005074560183	0.436420550102666	no	2126	0.423981323268463	1394	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p	cellular iron ion homeostasis	molecular_function	mitochondrion|integral to membrane
YJL060W	YJL060W	BNA3	hom	Verified	0.159831669308249	0.436506838134851	no	2127	0.440955547403562	1446	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate	kynurenic acid biosynthetic process	arylformamidase activity|kynurenine-oxoglutarate transaminase activity	mitochondrion|cytoplasm
YDR338C_p	YDR338C	YDR338C	hom	Uncharacterized	0.159503672637905	0.436636032507725	no	2128	0.454420563354323	1504	NA					Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily	transmembrane transport	antiporter activity	integral to membrane
YBR099C_d	YBR099C	YBR099C	hom	Dubious	0.158902929034135	0.436872676491632	no	2129	0.437827613148105	1439	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4	Unknown	Unknown	Unknown
YDR076W	YDR076W	RAD55	hom	Verified	0.157858990393477	0.43728395686342	no	2130	0.463427082232897	1535	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p	DNA recombinase assembly|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|protein heterodimerization activity	nucleus|Rhp55-Rhp57 complex
YCL022C_d	YCL022C	YCL022C	hom	Dubious	0.156687480555703	0.437745577135506	no	2131	0.406888819355761	1317	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W	Unknown	Unknown	Unknown
YCR100C_p	YCR100C	YCR100C	hom	Uncharacterized	0.156263974131171	0.43791247596492	no	2132	0.455512156797715	1479	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YLR451W	YLR451W	LEU3	hom	Verified	0.154762077090483	0.43850444451366	no	2133	0.439552499599004	1444	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation	negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDL012C	YDL012C	YDL012C	hom	Verified	0.154426431348473	0.43863675721029	no	2134	0.420057101559518	1394	NA	FT		PLASMA MEMBRANE		Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication	biological_process	molecular_function	plasma membrane
YGR208W	YGR208W	SER2	hom	Verified	0.153433256450282	0.439028310259183	no	2135	0.431304722663242	1425	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source	L-serine biosynthetic process	phosphoserine phosphatase activity	nucleus|cytoplasm
YKL005C	YKL005C	BYE1	hom	Verified	0.153403743500469	0.439039946471562	no	2136	0.439784646378288	1435	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit	negative regulation of transcription from RNA polymerase II promoter	methylated histone residue binding	nucleus
YGL158W	YGL158W	RCK1	hom	Verified	0.152739292162363	0.439301936815708	no	2137	0.436448044963715	1434	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION			Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication	protein phosphorylation|regulation of meiosis	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YGR136W	YGR136W	LSB1	hom	Verified	0.152732785702171	0.43930450241701	no	2138	0.419936961960134	1387	NA	FT		NUCLEUS		Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YJR131W	YJR131W	MNS1	hom	Verified	0.152292733192097	0.439478028070795	no	2139	0.441774992213386	1461	NA	FT	CARBOHYDRATE METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation	ER-associated protein catabolic process|protein deglycosylation involved in glycoprotein catabolic process	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum
YMR133W	YMR133W	REC114	hom	Verified	0.150806968425659	0.440063994565221	no	2140	0.417389728220418	1366	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YDR322W	YDR322W	MRPL35	hom	Verified	0.150130807186515	0.440330707404718	no	2141	0.44544672575141	1473	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YLR376C	YLR376C	PSY3	hom	Verified	0.149710291436261	0.440496594151757	no	2142	0.428341123574478	1426	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C	recombinational repair|error-free translesion synthesis	molecular_function	nucleus|Shu complex|cytoplasm
YER132C	YER132C	PMD1	hom	Verified	0.149112241922809	0.4407325331142	no	2143	0.441055736797594	1473	NA	FT	CELL CYCLE			Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions	sporulation resulting in formation of a cellular spore	molecular_function	cytoplasm
YJL118W	YJL118W	YJL118W	hom	Verified	0.148813543435787	0.440850381761535	no	2144	0.433388080332318	1419	NA					Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein	biological_process	molecular_function	ribosome
YDR019C	YDR019C	GCV1	hom	Verified	0.148597646112075	0.440935565259517	no	2145	0.450541366931347	1500	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm	glycine catabolic process|glycine metabolic process|one-carbon metabolic process	glycine dehydrogenase (decarboxylating) activity	mitochondrion|glycine cleavage complex
YGR220C	YGR220C	MRPL9	hom	Verified	0.148498126525842	0.440974832189975	no	2146	0.411537971478281	1352	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	cytoplasmic translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YJL191W	YJL191W	RPS14B	hom	Verified	0.14840379016512	0.441012054537612	no	2147	0.445794862870971	1467	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome|SSU rRNA binding	small-subunit processome|cytosolic small ribosomal subunit
YER144C	YER144C	UBP5	hom	Verified	0.148037953410732	0.441156407864839	no	2148	0.44713321716193	1481	NA	FT	PROTEOLYSIS	SITE OF POLARIZED GROWTH		Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck	protein deubiquitination	ubiquitin-specific protease activity	incipient cellular bud site|cellular bud neck
YDR119W_p	YDR119W	VBA4	hom	Uncharacterized	0.147637740061474	0.441314334599983	no	2149	0.426623213025902	1414	NA					Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YLR260W	YLR260W	LCB5	hom	Verified	0.146395466886282	0.441804602829821	no	2150	0.451468489833005	1502	NA	FT	LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules	response to heat|calcium-mediated signaling|sphingolipid metabolic process	D-erythro-sphingosine kinase activity	Golgi apparatus|membrane
YPL038W	YPL038W	MET31	hom	Verified	0.145614139673976	0.442113002560538	no	2151	0.435344259084166	1455	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication	regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YMR037C	YMR037C	MSN2	hom	Verified	0.14224209237102	0.443444392441346	no	2152	0.432385417488094	1439	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in respon