strainid	orf	gene	zyg	qualifier	SGTC_1498|4478-3555.score	SGTC_1498|4478-3555.expt.zyg.pval	SGTC_1498|4478-3555.expt.zyg.significant	SGTC_1498|4478-3555.expt.zyg.rank	strain.pval	strain.rank	clearance	Fclass	Fterms.BP	Fterms.CC	Fterms.complex	description	GO_process	GO_function	GO_component
YDR466W	YDR466W	PKH3	hom	Verified	6.10028714976244	5.29390430555739e-10	yes	1	8.02729323956446e-07	11	NA	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION			Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant	MAPK cascade involved in cell wall biogenesis|protein phosphorylation	protein kinase activity	cellular_component
YHR179W	YHR179W	OYE2	hom	Verified	4.71925503594975	1.18354951034185e-06	yes	2	7.71261123283112e-07	15	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS|MITOCHONDRION		Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress	apoptotic process	NADPH dehydrogenase activity	mitochondrion|nucleus|cytoplasm
YPL130W	YPL130W	SPO19	hom	Verified	4.39424556421288	5.55790543626096e-06	yes	3	6.80494780392608e-07	3	NA	FT	CELL CYCLE|MEMBRANE ORGANIZATION			Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation	meiosis|spore membrane bending pathway	molecular_function	fungal-type cell wall|prospore membrane
YPR146C_d	YPR146C	YPR146C	hom	Dubious	4.38395667696692	5.82714799147609e-06	yes	4	2.60841779171638e-06	25	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR047C	YHR047C	AAP1	hom	Verified	4.09654687009677	2.09679306740457e-05	yes	5	2.05846776308473e-05	7	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication	glycogen metabolic process|proteolysis	aminopeptidase activity	nucleus|cytoplasm
YGR208W	YGR208W	SER2	hom	Verified	4.04416024159466	2.62554983949586e-05	yes	6	1.22999966778845e-05	24	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source	L-serine biosynthetic process	phosphoserine phosphatase activity	nucleus|cytoplasm
YBR249C	YBR249C	ARO4	hom	Verified	3.61813052644904	0.000148369370085478	yes	7	0.000117938111781024	14	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress	aromatic amino acid family biosynthetic process	3-deoxy-7-phosphoheptulonate synthase activity	nucleus|cytoplasm
YPL185W_d	YPL185W	YPL185W	hom	Dubious	3.60830467522809	0.000154102211651646	yes	8	0.000196227483790541	9	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C	Unknown	Unknown	Unknown
YPR017C	YPR017C	DSS4	hom	Verified	3.57557677985005	0.000174728296594155	yes	9	0.000222964603295344	32	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING			Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol	post-Golgi vesicle-mediated transport	zinc ion binding|guanyl-nucleotide exchange factor activity	cytosol|membrane
YKL149C	YKL149C	DBR1	hom	Verified	3.4934658729817	0.000238396960540183	yes	10	0.000243790418854408	20	NA	FT	RNA PROCESSING	NUCLEUS		RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition	snoRNA metabolic process|pseudohyphal growth|RNA catabolic process|transposition, RNA-mediated	RNA lariat debranching enzyme activity	nucleus
YNL253W	YNL253W	TEX1	hom	Verified	3.48290307167798	0.000248003957878688	yes	11	0.000163192629748541	11	NA	FT	RNA LOCALIZATION	NUCLEUS		Protein involved in mRNA export, component of the transcription export (TREX) complex	mRNA export from nucleus	molecular_function	transcription export complex
YLR072W_p	YLR072W	YLR072W	hom	Uncharacterized	3.38465673460302	0.000356336590826029	yes	12	0.000420405337524595	21	NA	FT		ENDOMEMBRANE SYSTEM		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene	biological_process	molecular_function	cytoplasm
YJR025C	YJR025C	BNA1	hom	Verified	3.36914871048868	0.00037700368060274	yes	13	0.000499822711981002	25	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p	de novo NAD biosynthetic process from tryptophan	3-hydroxyanthranilate 3,4-dioxygenase activity	cytoplasm
YBL048W_d	YBL048W	RRT1	hom	Dubious	3.36199511728264	0.000386907459474061	yes	14	0.00100657914615227	37	NA					Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR031W	YBR031W	RPL4A	hom	Verified	3.2628617106568	0.000551466624814977	yes	15	0.000351579938964681	23	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR100W	YGR100W	MDR1	hom	Verified	3.19066785834856	0.00070972179222842	yes	16	0.00115411426102006	22	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM			Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function	intracellular protein transport	Rab GTPase activator activity	cytoplasm
YMR152W	YMR152W	YIM1	hom	Verified	3.17398929246599	0.000751796187443148	yes	17	0.000941897472608211	49	NA	FT	RESPONSE TO DNA DAMAGE|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	response to DNA damage stimulus	molecular_function	mitochondrion|lipid particle|cytoplasm
YML021C	YML021C	UNG1	hom	Verified	3.1539176269024	0.00080547274665235	yes	18	0.000656255519101716	43	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus	DNA repair	uracil DNA N-glycosylase activity	mitochondrion|nucleus
YLR047C	YLR047C	FRE8	hom	Verified	3.1510216180832	0.000813502236769174	yes	19	0.00134499141298219	37	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p	cellular metal ion homeostasis	oxidoreductase activity, oxidizing metal ions	integral to membrane|membrane
YDR129C	YDR129C	SAC6	hom	Verified	3.14082532286716	0.000842362407933831	yes	20	0.0300010964533455	268	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress	bipolar cellular bud site selection|actin filament organization|endocytosis|response to osmotic stress	actin filament binding|protein binding, bridging	actin filament bundle|mating projection tip|actin cortical patch
YHR136C	YHR136C	SPL2	hom	Verified	3.1014485198707	0.00096288177109716	yes	21	0.00112420191077992	33	NA					Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm	response to temperature stimulus	enzyme inhibitor activity	cytoplasm
YGR169C	YGR169C	PUS6	hom	Verified	3.02838315518189	0.0012293306804808	no	22	0.000160331466831978	16	NA	FT	RNA PROCESSING	MITOCHONDRION		tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|cytoplasm
YDR003W	YDR003W	RCR2	hom	Verified	2.99947723175324	0.0013522166788462	no	23	0.000447828515967679	19	NA	FT	VESICLE-MEDIATED TRANSPORT			Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication	vesicle-mediated transport	molecular_function	vesicle|integral to membrane|fungal-type vacuole|cytoplasm
YAL031C	YAL031C	GIP4	hom	Verified	2.95846930360711	0.00154585516154762	no	24	0.00100316977088699	33	NA	FT	CHROMOSOME SEGREGATION			Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate	chromosome segregation|regulation of phosphoprotein phosphatase activity	protein phosphatase 1 binding|protein phosphatase type 1 regulator activity	cytoplasm
YGR176W_d	YGR176W	YGR176W	hom	Dubious	2.9476364773802	0.00160106685662308	no	25	0.000603362105363573	26	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR141C_d	YMR141C	YMR141C	hom	Dubious	2.93339666189624	0.00167637621811471	no	26	0.00189044481109027	32	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCL001W-A_p	YCL001W-A	YCL001W-A	hom	Uncharacterized	2.9255428214052	0.0017192792456257	no	27	0.00455538446037109	78	NA					Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III	biological_process	molecular_function	cellular_component
YFR023W	YFR023W	PES4	hom	Verified	2.91943850778454	0.00175331284602832	no	28	0.00259262426521679	52	NA	FT		NUCLEUS		Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YJL201W	YJL201W	ECM25	hom	Verified	2.8696508879636	0.00205462610372313	no	29	0.00128760899168434	59	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p	fungal-type cell wall organization|filamentous growth	molecular_function	cytoplasm
YOL131W_p	YOL131W	YOL131W	hom	Uncharacterized	2.86909306304318	0.0020582532962633	no	30	0.00192143198625761	39	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR194C	YLR194C	YLR194C	hom	Verified	2.79230539059155	0.00261669687563462	no	31	0.00292022205035391	41	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall|anchored to plasma membrane
YER015W	YER015W	FAA2	hom	Verified	2.7170436216275	0.00329339628866337	no	32	0.0033030904773111	63	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome	long-chain fatty acid metabolic process	long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|medium-chain fatty acid-CoA ligase activity	mitochondrion|peroxisome
YJL013C	YJL013C	MAD3	hom	Verified	2.69670932181786	0.00350141847480227	no	33	0.00179406220092767	26	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover	distributive segregation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	mitotic checkpoint complex
YGR194C	YGR194C	XKS1	hom	Verified	2.69585263406226	0.00351043599712137	no	34	0.0011238720991504	23	NA	FT	CARBOHYDRATE METABOLISM			Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains	xylulose catabolic process	xylulokinase activity	cytoplasm
YNL269W	YNL269W	BSC4	hom	Verified	2.69446334599166	0.0035251040285142	no	35	0.00223435249544348	62	NA					Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p	biological_process	molecular_function	cellular_component
YOR010C	YOR010C	TIR2	hom	Verified	2.6918652355927	0.00355268251426828	no	36	0.00146658294269859	14	NA					Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis	response to stress	molecular_function	fungal-type cell wall
YGR004W	YGR004W	PEX31	hom	Verified	2.65936296009538	0.00391442858791819	no	37	0.00193646112048757	52	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p	peroxisome organization	molecular_function	integral to membrane|integral to peroxisomal membrane
YDL012C	YDL012C	YDL012C	hom	Verified	2.63474084406974	0.00421007720673044	no	38	0.00115117938810612	35	NA	FT		PLASMA MEMBRANE		Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication	biological_process	molecular_function	plasma membrane
YOR296W_p	YOR296W	YOR296W	hom	Uncharacterized	2.61326140827202	0.00448413388126812	no	39	0.000907005467693	27	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene	biological_process	molecular_function	cytoplasm
YMR184W	YMR184W	ADD37	hom	Verified	2.61191638643863	0.00450181358071647	no	40	0.00472985695620404	46	NA	FT	PROTEOLYSIS			Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process	molecular_function	cytoplasm
YDR469W	YDR469W	SDC1	hom	Verified	2.60107143196469	0.00464665505090624	no	41	0.00982158639170257	107	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30	histone H3-K4 methylation|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YBR162C	YBR162C	TOS1	hom	Verified	2.59731536179982	0.00469778089956759	no	42	0.00504540795145606	61	NA					Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C	biological_process	molecular_function	fungal-type cell wall|fungal-type vacuole
YGL262W_p	YGL262W	YGL262W	hom	Uncharacterized	2.54647170277252	0.00544090168297822	no	43	0.00337378165197221	42	NA					Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene	biological_process	molecular_function	cellular_component
YGL257C	YGL257C	MNT2	hom	Verified	2.54645249324519	0.00544120114527094	no	44	0.00484180614594725	45	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans	protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	cellular_component
YNL027W	YNL027W	CRZ1	hom	Verified	2.5447281290781	0.00546814245516154	no	45	0.00395456054025791	33	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS	NUCLEUS		Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress	regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to calcium ion|positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cell wall chitin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter by pheromones|ion homeostasis|Unknown|positive regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YJL165C	YJL165C	HAL5	hom	Verified	2.53479034911306	0.00562573207788906	no	46	0.00348575458041834	72	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS			Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication	cellular cation homeostasis|protein phosphorylation|cellular protein localization|protein dephosphorylation	protein kinase activity	cellular_component
YIR042C_p	YIR042C	YIR042C	hom	Uncharacterized	2.52093615647875	0.00585215428820096	no	47	0.00391306040319852	52	NA					Putative protein of unknown function; YIR042C is a non-essential gene	biological_process	molecular_function	cellular_component
YGR178C	YGR178C	PBP1	hom	Verified	2.51180199478715	0.00600582314956195	no	48	0.00894818724735113	132	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION	NUCLEUS|MITOCHONDRION		Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	positive regulation of translation|mRNA polyadenylation|stress granule assembly	molecular_function	mitochondrion|nucleus|polysome|cytoplasmic stress granule|cytoplasm
YLR283W_p	YLR283W	YLR283W	hom	Uncharacterized	2.49230209248981	0.00634590193912038	no	49	0.00401462256535071	57	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene	biological_process	molecular_function	mitochondrion
YPL015C	YPL015C	HST2	hom	Verified	2.4628544989476	0.0068917919317123	no	50	0.0122149178761617	104	NA	FT	GENE SILENCING	NUCLEUS		Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export	negative regulation of chromatin silencing at telomere|chronological cell aging|chromatin silencing at rDNA|negative regulation of mitotic recombination	NAD-dependent histone deacetylase activity	cytoplasm
YPR045C	YPR045C	THP3	hom	Verified	2.45975410462639	0.00695161184731816	no	51	0.00830619616026041	60	NA	FT	RNA PROCESSING	NUCLEUS|CHROMOSOME		Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes	mRNA splicing, via spliceosome	molecular_function	nucleus|transcriptionally active chromatin
YJL120W_d	YJL120W	YJL120W	hom	Dubious	2.45275755258357	0.00708829262627057	no	52	0.0269617854785974	237	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YGR224W	YGR224W	AZR1	hom	Verified	2.43398367398871	0.00746683432029614	no	53	0.00499702634935955	74	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole	azole transport	azole transporter activity	integral to membrane|plasma membrane
YNL082W	YNL082W	PMS1	hom	Verified	2.43265574622043	0.00749427192096297	no	54	0.00827819405286478	91	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL	mismatch repair|meiotic mismatch repair	double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding	nucleus|MutLalpha complex|cytoplasm
YJL115W	YJL115W	ASF1	hom	Verified	2.4201144143904	0.00775781220367204	no	55	0.00807454394361313	69	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition	DNA replication-independent nucleosome assembly|histone acetylation|nucleosome disassembly|histone exchange|positive regulation of histone acetylation|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere|DNA replication-dependent nucleosome assembly|regulation of transcription from RNA polymerase II promoter in response to stress	histone binding	chromatin assembly complex
YGR071C	YGR071C	ENV11	hom	Verified	2.41399771938865	0.00788928056143457	no	56	0.00407015467458715	65	NA	FT	VACUOLAR PROTEIN PROCESSING	NUCLEUS		Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	vacuole organization|vacuolar protein processing	molecular_function	nucleus
YLR014C	YLR014C	PPR1	hom	Verified	2.41361825764209	0.00789750064837106	no	57	0.0168107700714322	106	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding|zinc ion binding	nucleus
YDR229W	YDR229W	IVY1	hom	Verified	2.39500203911316	0.00831013642106238	no	58	0.01005010050777	81	NA	FT	MEMBRANE ORGANIZATION			Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase	vacuole fusion, non-autophagic	phospholipid binding	fungal-type vacuole membrane
YGR125W_p	YGR125W	YGR125W	hom	Uncharacterized	2.38725574164024	0.00848733922099902	no	59	0.00893306191648024	103	NA					Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YOR376W-A_p	YOR376W-A	YOR376W-A	hom	Uncharacterized	2.38168323562588	0.00861685727737398	no	60	0.00442000940218267	59	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YER118C	YER118C	SHO1	hom	Verified	2.37183865370117	0.00884990901303369	no	61	0.008160104979568	51	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p	signal transduction involved in filamentous growth|establishment of cell polarity|osmosensory signaling pathway|cellular response to heat|cytokinesis	osmosensor activity|MAP-kinase scaffold activity	integral to membrane|plasma membrane|plasma membrane part|cellular bud|cellular bud neck|mating projection tip
YLR418C	YLR418C	CDC73	hom	Verified	2.36204988662686	0.00908709819126599	no	62	0.0399708839787916	282	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress	transcription elongation from RNA polymerase I promoter|negative regulation of DNA recombination|mRNA 3'-end processing|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair|transcription elongation from RNA polymerase II promoter	chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YPL226W	YPL226W	NEW1	hom	Verified	2.35290297965909	0.0093137468033047	no	63	0.0092698508321145	141	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM|RNA LOCALIZATION	NUCLEUS|MITOCHONDRION		ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction	ribosomal small subunit biogenesis|poly(A)+ mRNA export from nucleus	ATPase activity|ATP binding	mitochondrion|polysome|cytoplasm
YGR108W	YGR108W	CLB1	hom	Verified	2.33735249272068	0.00971043159302199	no	64	0.00743864282060588	81	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|meiotic G2/MI transition|regulation of cyclin-dependent protein kinase activity|mitotic spindle organization in nucleus|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YHR154W	YHR154W	RTT107	hom	Verified	2.33006661371095	0.00990131532950522	no	65	0.0186391698298145	160	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress	negative regulation of transposition, RNA-mediated|double-strand break repair	molecular_function	Cul8-RING ubiquitin ligase complex|nucleus
YDR534C	YDR534C	FIT1	hom	Verified	2.32117511138338	0.010138697433418	no	66	0.00388656700340442	43	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall	siderophore transport	molecular_function	fungal-type cell wall
YHR181W	YHR181W	SVP26	hom	Verified	2.31953812386637	0.010182938235692	no	67	0.0127254984623319	111	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment	protein retention in Golgi apparatus|fungal-type cell wall organization|protein glycosylation|ER to Golgi vesicle-mediated transport	COPII adaptor activity	integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum|integral to Golgi membrane|ER to Golgi transport vesicle
YOL159C-A	YOL159C-A	YOL159C-A	hom	Verified	2.29594709999138	0.0108394531180776	no	68	0.00547372013914871	92	NA	FT		NUCLEUS		Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	nucleus|cytoplasm
YLR232W_d	YLR232W	YLR232W	hom	Dubious	2.28922340199637	0.0110331877790776	no	69	0.00702795914172535	68	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5	Unknown	Unknown	Unknown
YGL158W	YGL158W	RCK1	hom	Verified	2.26591685331235	0.0117282372684034	no	70	0.00592075315441257	74	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION			Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication	protein phosphorylation|regulation of meiosis	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YGR153W_p	YGR153W	YGR153W	hom	Uncharacterized	2.2652060494971	0.0117500190447449	no	71	0.0105108364524801	88	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJL187C	YJL187C	SWE1	hom	Verified	2.26153266016851	0.0118631463075217	no	72	0.0083830397598359	93	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH		Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate	negative regulation of spindle pole body separation|G2/M transition size control checkpoint|protein phosphorylation|re-entry into mitotic cell cycle|G2/M transition of mitotic cell cycle|cell shape checkpoint|regulation of cyclin-dependent protein kinase activity|regulation of cell size|regulation of meiosis	protein tyrosine kinase activity|protein kinase activity	nucleus|cellular bud neck
YPL119C-A_p	YPL119C-A	YPL119C-A	hom	Uncharacterized	2.26096724173215	0.0118806428257651	no	73	0.0104176236789202	85	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YPR179C	YPR179C	HDA3	hom	Verified	2.25717804210456	0.0119984759493533	no	74	0.0116436652337162	111	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p	negative regulation of transcription from RNA polymerase II promoter|chromosome segregation|gene silencing by RNA|gene silencing involved in chronological cell aging|histone deacetylation	histone deacetylase activity|chromatin binding|DNA binding	nucleus|HDA1 complex
YGR010W	YGR010W	NMA2	hom	Verified	2.25546691476103	0.0120520183620246	no	75	0.0130726165072974	72	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication	NAD biosynthetic process	nicotinamide-nucleotide adenylyltransferase activity	nucleus
YMR237W	YMR237W	BCH1	hom	Verified	2.25166035329849	0.0121718719575017	no	76	0.0149744036963758	141	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication	Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process	molecular_function	ribosome|clathrin-coated vesicle|exomer complex
YER156C_p	YER156C	YER156C	hom	Uncharacterized	2.24993851871514	0.0122264241845965	no	77	0.0108201924993448	90	NA	FT		NUCLEUS		Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1	biological_process	molecular_function	nucleus|cytoplasm
YOL031C	YOL031C	SIL1	hom	Verified	2.24500537688898	0.0123838936939069	no	78	0.00920559722510845	115	NA	FT	PROTEIN LOCALIZATION	ENDOPLASMIC RETICULUM		Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein	SRP-dependent cotranslational protein targeting to membrane, translocation	adenyl-nucleotide exchange factor activity	endoplasmic reticulum
YKL072W	YKL072W	STB6	hom	Verified	2.24053375649912	0.0125281459124271	no	79	0.00471641429773844	46	NA					Protein that binds Sin3p in a two-hybrid assay	biological_process	molecular_function	cellular_component
YGL033W	YGL033W	HOP2	hom	Verified	2.2401801981925	0.012539613335136	no	80	0.0317820007841582	211	NA	FF|FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair	synapsis|reciprocal meiotic recombination	protein binding|double-stranded DNA binding	condensed nuclear chromosome
YCR098C	YCR098C	GIT1	hom	Verified	2.236432622871	0.012661723099552	no	81	0.013547197583604	157	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability	transmembrane transport|glycerophosphodiester transport	glycerophosphodiester transmembrane transporter activity	integral to membrane|plasma membrane
YLR097C	YLR097C	HRT3	hom	Verified	2.22152583971117	0.0131576832767409	no	82	0.00826289391157588	67	NA	FT	PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YML100W-A_p	YML100W-A	YML100W-A	hom	Uncharacterized	2.21342085580469	0.013434322057072	no	83	0.00645408093631358	39	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YNR071C_p	YNR071C	YNR071C	hom	Uncharacterized	2.21329240989304	0.0134387462840639	no	84	0.0102730180852148	94	NA	FT	CARBOHYDRATE METABOLISM			Putative aldose 1-epimerase	biological_process	molecular_function	cellular_component
YMR016C	YMR016C	SOK2	hom	Verified	2.21265133209416	0.0134608465601998	no	85	0.00435295848690965	51	NA	FT		NUCLEUS		Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication	pseudohyphal growth	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YEL040W	YEL040W	UTR2	hom	Verified	2.20987196170563	0.0135570248241167	no	86	0.0117902008019816	63	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|CYTOSKELETON		Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck	cell wall chitin metabolic process|fungal-type cell wall organization	transferase activity, transferring glycosyl groups	cellular bud neck septin ring|fungal-type cell wall
YPL202C	YPL202C	AFT2	hom	Verified	2.1984681525117	0.0139578808285507	no	87	0.0104375461594647	112	NA	FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication	cellular response to oxidative stress|cellular iron ion homeostasis|positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	mitochondrion|nucleus
YBL078C	YBL078C	ATG8	hom	Verified	2.19373763432101	0.0141271383078354	no	88	0.0235346019415548	171	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM		Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis	piecemeal microautophagy of nucleus|mitochondrion degradation|cellular membrane fusion|ER to Golgi vesicle-mediated transport|CVT pathway|autophagic vacuole assembly	molecular_function	cytosol|fungal-type vacuole membrane|pre-autophagosomal structure|extrinsic to membrane|autophagic vacuole
YJR075W	YJR075W	HOC1	hom	Verified	2.18859009904009	0.0143133230486613	no	89	0.00990700029488622	113	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele	cell wall mannoprotein biosynthetic process|substituted mannan metabolic process	alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups	alpha-1,6-mannosyltransferase complex
YBL049W	YBL049W	MOH1	hom	Verified	2.17909914343744	0.0146621519440233	no	90	0.0247544893241351	197	NA					Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase	biological_process	molecular_function	cellular_component
YOL038C-A_p	YOL038C-A	YOL038C-A	hom	Uncharacterized	2.17132132988283	0.0149534455253639	no	91	0.00763711907899135	70	NA					Putative protein of unknown function; identified by SAGE analysis	biological_process	molecular_function	cellular_component
YDR335W	YDR335W	MSN5	hom	Verified	2.1615194272943	0.0153276189571174	no	92	0.021584825935229	162	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|protein export from nucleus	protein binding|importin-alpha export receptor activity	integral to membrane|nucleus|cytoplasm
YIL137C	YIL137C	TMA108	hom	Verified	2.15700792142731	0.0155025236191273	no	93	0.0136353878871517	121	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS			Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease	ribosome biogenesis	molecular_function	ribosome|cytoplasm
YLR180W	YLR180W	SAM1	hom	Verified	2.15271827037206	0.0156704133581737	no	94	0.011868786456374	97	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication	methionine metabolic process|S-adenosylmethionine biosynthetic process	methionine adenosyltransferase activity	cytoplasm
YOR304C-A_p	YOR304C-A	YOR304C-A	hom	Uncharacterized	2.14482393896736	0.0159834632155444	no	95	0.0222533127854431	162	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck	biological_process	molecular_function	cellular bud|mating projection tip|cellular bud neck|cytoplasm
YCR102W-A_d	YCR102W-A	YCR102W-A	hom	Dubious	2.13614743171156	0.0163336993348942	no	96	0.00878289182842733	70	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL096C_d	YDL096C	OPI6	hom	Dubious	2.13544505852398	0.016362336736407	no	97	0.0109904619642776	92	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential	Unknown	Unknown	Unknown
YJR011C_p	YJR011C	YJR011C	hom	Uncharacterized	2.13160015436873	0.0165198655292214	no	98	0.0116561781424724	79	NA					Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cellular_component
YNL235C_d	YNL235C	YNL235C	hom	Dubious	2.12358361712444	0.0168524883362929	no	99	0.0283699105723358	187	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex	Unknown	Unknown	Unknown
YLR019W	YLR019W	PSR2	hom	Verified	2.12209032199584	0.0169150769796617	no	100	0.0158566320631239	108	NA	FT		PLASMA MEMBRANE		Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p	response to stress	phosphoprotein phosphatase activity	plasma membrane
YLR236C_d	YLR236C	YLR236C	hom	Dubious	2.12199990901311	0.0169188728419548	no	101	0.0111021919208375	108	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL242W_d	YDL242W	YDL242W	hom	Dubious	2.11661651593338	0.0171462036296885	no	102	0.0105293410857207	75	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBL021C	YBL021C	HAP3	hom	Verified	2.11171072500637	0.0173556342773634	no	103	0.0192585904464793	66	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex
YFR012W	YFR012W	DCV1	hom	Verified	2.11169157899736	0.0173564558909174	no	104	0.0104040939023833	86	NA					Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YER097W_d	YER097W	YER097W	hom	Dubious	2.11035225342693	0.0174140129288605	no	105	0.0295340700805197	180	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR066W	YCR066W	RAD18	hom	Verified	2.10100884813808	0.0178200947718992	no	106	0.0285903528327512	247	NA	FF|FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA	protein monoubiquitination|error-free translesion synthesis|error-free postreplication DNA repair|error-prone translesion synthesis	ubiquitin-protein ligase activity|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding	nuclear chromatin|nucleus
YNL076W	YNL076W	MKS1	hom	Verified	2.09624477057051	0.018030241639546	no	107	0.0129963510735379	89	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling	regulation of nitrogen utilization|negative regulation of transcription from RNA polymerase II promoter|Unknown|mitochondria-nucleus signaling pathway	molecular_function	cytoplasm
YLR389C	YLR389C	STE23	hom	Verified	2.09521473660804	0.0180759539241119	no	108	0.0105402398134656	109	NA	FT	PROTEOLYSIS			Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family	peptide pheromone maturation	metallopeptidase activity|metalloendopeptidase activity	extrinsic to membrane
YER062C	YER062C	HOR2	hom	Verified	2.0913112960255	0.0182500839385976	no	109	0.0112312991975573	53	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication	cellular carbohydrate metabolic process|glycerol biosynthetic process|response to osmotic stress	glycerol-1-phosphatase activity	nucleus|cytoplasm
YJR049C	YJR049C	UTR1	hom	Verified	2.0884244497949	0.0183797819408793	no	110	0.0299738940666033	251	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM	NUCLEUS		ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication	cellular iron ion homeostasis|NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	nucleus|cytoplasm
YHR125W_d	YHR125W	YHR125W	hom	Dubious	2.08657675151958	0.0184632053148461	no	111	0.0242055403572685	185	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR016C	YOR016C	ERP4	hom	Verified	2.08529883078842	0.0185210917494976	no	112	0.0125136476692504	63	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane
YOR031W	YOR031W	CRS5	hom	Verified	2.08388684277648	0.0185852307124106	no	113	0.0139470375651975	113	NA					Copper-binding metallothionein, required for wild-type copper resistance	response to metal ion	copper ion binding	cytoplasm
YGR020C	YGR020C	VMA7	hom	Verified	2.0833602582761	0.0186091989559542	no	114	0.046569170786	258	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YMR126C_p	YMR126C	DLT1	hom	Uncharacterized	2.0822376237442	0.0186603851265716	no	115	0.0109662031474172	112	NA					Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)	biological_process	molecular_function	cellular_component
YGL191W	YGL191W	COX13	hom	Verified	2.06502213236884	0.0194604531069799	no	116	0.0135391788259674	127	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes	mitochondrial respiratory chain supercomplex assembly|aerobic respiration	enzyme regulator activity|cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YBL079W	YBL079W	NUP170	hom	Verified	2.05655216573299	0.0198646617484092	no	117	0.0322404042484734	225	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication	nucleocytoplasmic transport|chromosome segregation|protein targeting to nuclear inner membrane|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YNL105W_d	YNL105W	RRT16	hom	Dubious	2.0559572451157	0.0198933187497424	no	118	0.00847393417477235	69	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription	Unknown	Unknown	Unknown
YOR291W	YOR291W	YPK9	hom	Verified	2.05331798452022	0.0200208738738534	no	119	0.0131623910741965	71	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YMR322C_p	YMR322C	SNO4	hom	Uncharacterized	2.04889754296777	0.0202360673295472	no	120	0.00841126024703578	58	NA	FT	PROTEOLYSIS			Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation	biological_process	cysteine-type peptidase activity	cellular_component
YJR120W	YJR120W	YJR120W	hom	Verified	2.04792862218297	0.0202834969231976	no	121	0.0193464278291688	111	NA	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p	cellular respiration|sterol transport|mitochondrion organization	molecular_function	cellular_component
YGR059W	YGR059W	SPR3	hom	Verified	2.04766180239172	0.0202965745429311	no	122	0.0186502587507776	144	NA	FT	CELL CYCLE	SITE OF POLARIZED GROWTH|CYTOSKELETON		Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI	ascospore formation	structural molecule activity	septin complex|ascospore wall|prospore membrane
YCL012C	YCL012C	YCL012C	hom	Verified	2.04369345787094	0.0204919199603156	no	123	0.0148572288147863	99	NA					Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene	biological_process	molecular_function	cellular_component
YIL116W	YIL116W	HIS5	hom	Verified	2.0436495515022	0.0204940901709748	no	124	0.0189328725307299	122	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts	histidine biosynthetic process	histidinol-phosphate transaminase activity	intracellular
YPR058W	YPR058W	YMC1	hom	Verified	2.04304601384157	0.0205239416646155	no	125	0.0147528073689171	91	NA	FT		MITOCHONDRION		Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication	mitochondrial transport	organic acid transmembrane transporter activity	mitochondrion|integral to membrane
YHR110W	YHR110W	ERP5	hom	Verified	2.04198950019202	0.0205762864319555	no	126	0.0178383843760207	134	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YNL115C_p	YNL115C	YNL115C	hom	Uncharacterized	2.03687566781579	0.0208312515273025	no	127	0.0155114921402407	136	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YGR256W	YGR256W	GND2	hom	Verified	2.03414526394066	0.0209684756926003	no	128	0.0151301556626192	132	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	phosphogluconate dehydrogenase (decarboxylating) activity	cytosol|plasma membrane
YKL025C	YKL025C	PAN3	hom	Verified	2.03022235204902	0.0211669713941924	no	129	0.0328854170238179	189	NA	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION			Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes	DNA repair|mRNA 3'-end processing|postreplication repair	poly(A)-specific ribonuclease activity	PAN complex|cytoplasm
YLR054C	YLR054C	OSW2	hom	Verified	2.02954393876773	0.0212014591858458	no	130	0.0232139172934086	106	NA	FT	CELL WALL ORG/BIOGENESIS			Protein of unknown function proposed to be involved in the assembly of the spore wall	ascospore wall assembly	molecular_function	integral to membrane|prospore membrane|cytoplasm
YPR084W_p	YPR084W	YPR084W	hom	Uncharacterized	2.02688387768486	0.0213371448504663	no	131	0.0197789484259038	145	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR008C	YOR008C	SLG1	hom	Verified	2.02351806865198	0.0215098813102044	no	132	0.0688632112643162	323	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response	positive regulation of endocytosis|Rho protein signal transduction|actin cytoskeleton organization|fungal-type cell wall organization|response to heat|peroxisome degradation|establishment of cell polarity|response to osmotic stress	transmembrane signaling receptor activity	plasma membrane|mating projection tip|cellular bud neck
YJL082W	YJL082W	IML2	hom	Verified	2.0218390926635	0.0215964888490517	no	133	0.0201536586726688	140	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|nucleus|cytoplasm
YDR112W_d	YDR112W	IRC2	hom	Dubious	2.01929250141504	0.0217284134043307	no	134	0.018737995089053	151	NA					Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci	Unknown	Unknown	Unknown
YBL044W_p	YBL044W	YBL044W	hom	Uncharacterized	2.01599993030223	0.0218999915391676	no	135	0.021855019141852	109	NA					Putative protein of unknown function; YBL044W is not an essential protein	biological_process	molecular_function	cellular_component
YDR010C_d	YDR010C	YDR010C	hom	Dubious	2.01328657154611	0.0220422451178991	no	136	0.0333735371700877	190	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR153W	YJR153W	PGU1	hom	Verified	2.01008063048532	0.0222113278721662	no	137	0.0167959778243645	90	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins	pseudohyphal growth|pectin catabolic process	polygalacturonase activity	extracellular region
YKL198C	YKL198C	PTK1	hom	Verified	2.00441259283232	0.0225129407354449	no	138	0.0272766540805036	144	NA	FT	PROTEIN PHOSPHORYLATION			Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein	polyamine transport	protein kinase activity	cellular_component
YKR005C_p	YKR005C	YKR005C	hom	Uncharacterized	1.99785254697212	0.0228663242624156	no	139	0.0196444959302469	132	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLL020C_d	YLL020C	YLL020C	hom	Dubious	1.9957233217918	0.022982023544712	no	140	0.0162832632812624	133	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1	Unknown	Unknown	Unknown
YKL063C_p	YKL063C	YKL063C	hom	Uncharacterized	1.99298832979255	0.0231313625021405	no	141	0.0121909899687688	103	NA	FT		GOLGI APPARATUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi	biological_process	molecular_function	Golgi apparatus
YGR138C	YGR138C	TPO2	hom	Verified	1.98982615746227	0.0233050444627479	no	142	0.00754404741520489	84	NA	FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication	spermine transport	spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YPR032W	YPR032W	SRO7	hom	Verified	1.98765279540787	0.0234250514870841	no	143	0.02574215226492	205	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING	PLASMA MEMBRANE		Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication	establishment of cell polarity|exocytosis|Golgi to plasma membrane transport|small GTPase mediated signal transduction	SNARE binding|Rab GTPase binding	cytosol|plasma membrane
YOL155C	YOL155C	HPF1	hom	Verified	1.98694656886378	0.0234641591169342	no	144	0.0279524933862321	195	NA	FT	CELL WALL ORG/BIOGENESIS			Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines	fungal-type cell wall organization	glucosidase activity	fungal-type cell wall|extracellular region
YKL140W	YKL140W	TGL1	hom	Verified	1.97775840892571	0.0239779837611421	no	145	0.00896114062570269	65	NA	FT	LIPID METABOLISM			Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes	cellular lipid metabolic process|sterol metabolic process	lipase activity|sterol esterase activity	integral to membrane|lipid particle
YDR264C	YDR264C	AKR1	hom	Verified	1.97360690840452	0.0242132287994516	no	146	0.070869064628442	344	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication	protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation	palmitoyltransferase activity	integral to membrane|Golgi apparatus|membrane
YER183C	YER183C	FAU1	hom	Verified	1.97128071654051	0.0243458878939294	no	147	0.0273379668929894	182	NA	FT	COFACTOR METABOLISM	MITOCHONDRION		5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis	folic acid-containing compound biosynthetic process	5-formyltetrahydrofolate cyclo-ligase activity	mitochondrion
YDR290W_d	YDR290W	YDR290W	hom	Dubious	1.97023051381313	0.0244059789642508	no	148	0.0454086551708996	231	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103	Unknown	Unknown	Unknown
YDL011C_d	YDL011C	YDL011C	hom	Dubious	1.97021155482888	0.02440706491289	no	149	0.0194560644552735	120	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W	Unknown	Unknown	Unknown
YKL109W	YKL109W	HAP4	hom	Verified	1.95317283172861	0.0253995595920183	no	150	0.0263577640958539	173	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex	regulation of cellular respiration|carbon catabolite activation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity	CCAAT-binding factor complex
YGL235W_p	YGL235W	YGL235W	hom	Uncharacterized	1.9492438337959	0.0256331562599578	no	151	0.0180879014750788	82	NA					Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	biological_process	molecular_function	cellular_component
YDR289C	YDR289C	RTT103	hom	Verified	1.94769789364139	0.0257255611509814	no	152	0.0371093924860888	225	NA	FT	RNA PROCESSING	NUCLEUS|CHROMOSOME		Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition	negative regulation of transposition, RNA-mediated|mRNA 3'-end processing	RNA polymerase II core binding	nuclear chromatin|site of double-strand break
YOL067C	YOL067C	RTG1	hom	Verified	1.94580508640163	0.0258390787088034	no	153	0.0412444310848039	234	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus	cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus|cytoplasm
YGR187C	YGR187C	HGH1	hom	Verified	1.94366543330566	0.025967904800985	no	154	0.0239377705989766	164	NA					Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	cytoplasm
YDR279W	YDR279W	RNH202	hom	Verified	1.93781435044437	0.0263229381680153	no	155	0.0180962382470237	106	NA	FT		NUCLEUS		Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome	RNA catabolic process|DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus
YBR218C	YBR218C	PYC2	hom	Verified	1.92547314504143	0.0270850962496574	no	156	0.0336001290488902	170	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication	NADPH regeneration|gluconeogenesis	pyruvate carboxylase activity	cytosol
YMR008C	YMR008C	PLB1	hom	Verified	1.9220844108106	0.0272975686530081	no	157	0.0244547257803707	103	NA	FT	LIPID METABOLISM	PLASMA MEMBRANE		Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol	glycerophospholipid metabolic process	lysophospholipase activity	periplasmic space|plasma membrane
YGR220C	YGR220C	MRPL9	hom	Verified	1.91914332140008	0.0274830990927119	no	158	0.0230739208402873	106	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	cytoplasmic translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YLL030C_d	YLL030C	RRT7	hom	Dubious	1.91875256858317	0.027507827583555	no	159	0.020474461554123	126	NA					Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YFR020W_p	YFR020W	YFR020W	hom	Uncharacterized	1.91789111840352	0.027562409325301	no	160	0.0306372320319328	179	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YEL008W_d	YEL008W	YEL008W	hom	Dubious	1.91162318264976	0.0279622718149779	no	161	0.0194129333773324	125	NA					Hypothetical protein predicted to be involved in metabolism	Unknown	Unknown	Unknown
YBR134W_d	YBR134W	YBR134W	hom	Dubious	1.91129200366699	0.027983533048167	no	162	0.0232293004582805	196	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR241W_p	YLR241W	YLR241W	hom	Uncharacterized	1.9090028914079	0.028130859335838	no	163	0.0189050781324534	98	NA					Putative protein of unknown function, may be involved in detoxification	biological_process	molecular_function	integral to membrane
YLR313C	YLR313C	SPH1	hom	Verified	1.90890722275868	0.0281370305611695	no	164	0.0348278411159911	225	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p	bipolar cellular bud site selection|pseudohyphal growth|invasive filamentous growth|mating projection assembly	molecular_function	incipient cellular bud site|cellular bud neck|cellular bud tip|mating projection
YGR032W	YGR032W	GSC2	hom	Verified	1.90720701643757	0.0282468926330556	no	165	0.0177178516397832	94	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE|CYTOSKELETON		Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)	ascospore wall assembly|(1->3)-beta-D-glucan biosynthetic process	1,3-beta-D-glucan synthase activity	1,3-beta-D-glucan synthase complex|integral to membrane|actin cap|prospore membrane
YKL100C_p	YKL100C	YKL100C	hom	Uncharacterized	1.90565447952804	0.0283475244239627	no	166	0.0157127330618583	97	NA	FT	PROTEOLYSIS			Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene	biological_process	molecular_function	integral to membrane
YHR004C	YHR004C	NEM1	hom	Verified	1.90348135164917	0.0284888823757769	no	167	0.0348592987855658	231	NA	FF|FT	LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|mitochondrion|integral to membrane
YOR321W	YOR321W	PMT3	hom	Verified	1.89941511957988	0.0287549585509084	no	168	0.0247902991117921	154	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication	protein O-linked glycosylation|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YPR046W	YPR046W	MCM16	hom	Verified	1.89645246742401	0.0289501198167216	no	169	0.0530626207335048	273	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YDR269C_d	YDR269C	YDR269C	hom	Dubious	1.89539675971926	0.0290199288311741	no	170	0.0257062023578803	162	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR019W	YGR019W	UGA1	hom	Verified	1.89344886382008	0.0291491012412355	no	171	0.0220851639040778	132	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress	nitrogen utilization|gamma-aminobutyric acid catabolic process	4-aminobutyrate transaminase activity	intracellular
YHL012W_p	YHL012W	YHL012W	hom	Uncharacterized	1.88840188022781	0.0294860095641218	no	172	0.0167651499637804	104	NA					Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDR056C_p	YDR056C	YDR056C	hom	Uncharacterized	1.88500374618762	0.0297146660221569	no	173	0.0255447169876046	145	NA	FT		ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein	biological_process	molecular_function	endoplasmic reticulum
YDR031W	YDR031W	MIC14	hom	Verified	1.88349053978234	0.0298169603461914	no	174	0.0210319863714605	95	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	aerobic respiration	molecular_function	nucleus|mitochondrial intermembrane space|cytoplasm
YDL187C_d	YDL187C	YDL187C	hom	Dubious	1.88141933306583	0.0299574495014278	no	175	0.0411292850185153	175	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL040C	YKL040C	NFU1	hom	Verified	1.87976255292314	0.0300702230636524	no	176	0.0196015879532477	117	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria	cellular iron ion homeostasis|iron-sulfur cluster assembly|intracellular sequestering of iron ion	molecular_function	mitochondrion|mitochondrial matrix
YPL102C_d	YPL102C	YPL102C	hom	Dubious	1.87940379575611	0.0300946892195445	no	177	0.0308774378412542	195	NA					Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4	Unknown	Unknown	Unknown
YAR050W	YAR050W	FLO1	hom	Verified	1.87830944853521	0.0301694223725451	no	178	0.0413966000438142	188	NA	FT		PLASMA MEMBRANE		Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p	cellular response to stress|flocculation via cell wall protein-carbohydrate interaction|flocculation	mannose binding	fungal-type cell wall
YLR417W	YLR417W	VPS36	hom	Verified	1.87611209043598	0.030319944920275	no	179	0.0685677794955374	387	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome	negative regulation of transcription from RNA polymerase II promoter by glucose|protein retention in Golgi apparatus|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	ubiquitin binding	ESCRT II complex
YDR192C	YDR192C	NUP42	hom	Verified	1.87443629145024	0.0304351576741213	no	180	0.0264977241539001	135	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p	poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YOL015W	YOL015W	IRC10	hom	Verified	1.87257540453249	0.0305635201671596	no	181	0.0441689607543861	192	NA					Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YGR197C	YGR197C	SNG1	hom	Verified	1.8714095922461	0.0306441651840796	no	182	0.0224421453487419	132	NA	FT		PLASMA MEMBRANE		Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance	nucleobase-containing compound transport	molecular_function	integral to membrane|plasma membrane
YBL107C	YBL107C	MIC23	hom	Verified	1.86335491064947	0.0312061746649931	no	183	0.0390483068165039	198	NA					Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C)	biological_process	molecular_function	cytoplasm
YDR252W	YDR252W	BTT1	hom	Verified	1.85069784469617	0.0321065171579627	no	184	0.027881329145598	125	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3	'de novo' cotranslational protein folding	unfolded protein binding	nascent polypeptide-associated complex|CCR4-NOT complex
YDR092W	YDR092W	UBC13	hom	Verified	1.84922550435951	0.0322126287257108	no	185	0.0223693902287791	153	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus	postreplication repair|protein monoubiquitination|protein polyubiquitination|free ubiquitin chain polymerization	ubiquitin-protein ligase activity	ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YBR281C	YBR281C	DUG2	hom	Verified	1.84774945045583	0.0323192983285899	no	186	0.0304231276352966	217	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS	NUCLEUS		Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	peptidase activity|gamma-glutamyltransferase activity|omega peptidase activity	nucleus|cytoplasm
YDL241W_p	YDL241W	YDL241W	hom	Uncharacterized	1.84689470469344	0.0323812011761904	no	187	0.0236008154293787	117	NA					Putative protein of unknown function; YDL241W is not an essential gene	biological_process	molecular_function	cellular_component
YGL126W	YGL126W	SCS3	hom	Verified	1.84505069479577	0.0325150822604988	no	188	0.0374438745611773	180	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol	phospholipid metabolic process	molecular_function	integral to membrane|endoplasmic reticulum
YPR153W	YPR153W	YPR153W	hom	Verified	1.84428124936038	0.0325710813422548	no	189	0.0234563258873204	146	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YDR034C	YDR034C	LYS14	hom	Verified	1.84320570386408	0.0326494912135609	no	190	0.0319516008444628	176	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YBR230C	YBR230C	OM14	hom	Verified	1.83588311016198	0.0331874730806448	no	191	0.041189053209223	205	NA	FT		MITOCHONDRION		Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron	biological_process	molecular_function	mitochondrion|integral to mitochondrial outer membrane
YGR011W_d	YGR011W	YGR011W	hom	Dubious	1.83456470570873	0.0332851061029113	no	192	0.0230296512577204	105	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL101W_p	YGL101W	YGL101W	hom	Uncharacterized	1.83411182412796	0.0333186982973677	no	193	0.0354833102375811	128	NA	FT		NUCLEUS		Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p	biological_process	molecular_function	nucleus|cytoplasm
YIL160C	YIL160C	POT1	hom	Verified	1.8300609501482	0.03362041265899	no	194	0.0277891586835843	145	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids	fatty acid beta-oxidation	mRNA binding|acetyl-CoA C-acyltransferase activity	peroxisomal matrix|peroxisome
YBR286W	YBR286W	APE3	hom	Verified	1.82579687830163	0.0339404318603092	no	195	0.0395434976214025	240	NA	FT	PROTEOLYSIS			Vacuolar aminopeptidase Y, processed to mature form by Prb1p	vacuolar protein catabolic process	aminopeptidase activity	fungal-type vacuole
YJL064W_d	YJL064W	YJL064W	hom	Dubious	1.82531889890249	0.0339764599289889	no	196	0.030666702287916	178	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1	Unknown	Unknown	Unknown
YDL157C_p	YDL157C	YDL157C	hom	Uncharacterized	1.8205771975827	0.034335575811309	no	197	0.0159385169633043	67	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGR174W-A_p	YGR174W-A	YGR174W-A	hom	Uncharacterized	1.81821362835336	0.0345157439125749	no	198	0.0202378364627791	123	NA					Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YAL017W	YAL017W	PSK1	hom	Verified	1.8167450546281	0.0346280797630525	no	199	0.0283065081014142	108	NA	FT	SIGNALING|TRANSLATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY			PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication	regulation of (1->6)-beta-D-glucan biosynthetic process|negative regulation of glycogen biosynthetic process|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YER087C-B	YER087C-B	SBH1	hom	Verified	1.81569883226488	0.0347082916487072	no	200	0.0606682279572038	275	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p	posttranslational protein targeting to membrane, translocation|SRP-dependent cotranslational protein targeting to membrane, translocation	ARF guanyl-nucleotide exchange factor activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity	Sec61 translocon complex
YGR141W	YGR141W	VPS62	hom	Verified	1.81498364550145	0.0347632114149793	no	201	0.0267345767987769	133	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT			Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins	protein targeting to vacuole	molecular_function	cellular_component
YKR034W	YKR034W	DAL80	hom	Verified	1.81218564219989	0.0349787584010282	no	202	0.0346423973050678	188	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication	nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YDR326C	YDR326C	YSP2	hom	Verified	1.80165220883643	0.0358000707967218	no	203	0.0396288894983387	243	NA	FT		MITOCHONDRION		Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication	apoptotic process	molecular_function	mitochondrion
YLL039C	YLL039C	UBI4	hom	Verified	1.79973520683531	0.0359512295578032	no	204	0.0251944615674511	131	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress	protein deubiquitination|ascospore formation|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress	ATP-dependent protein binding|protein tag	cytoplasm
YLR356W	YLR356W	ATG33	hom	Verified	1.79956459915957	0.0359647075508348	no	205	0.0311022213685538	148	NA	FT		MITOCHONDRION		Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes	mitochondrion degradation	molecular_function	mitochondrion|integral to membrane
YML009C	YML009C	MRPL39	hom	Verified	1.7904884265529	0.0366877130777868	no	206	0.0272174516485362	132	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YKL146W	YKL146W	AVT3	hom	Verified	1.78938093458099	0.0367767438221298	no	207	0.0379440868552268	167	NA	FT	VACUOLAR TRANSPORT			Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid export from vacuole	transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YNR019W	YNR019W	ARE2	hom	Verified	1.78933008472446	0.036780835856298	no	208	0.0372251003651208	150	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication	ergosterol metabolic process	ergosterol O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YIL084C	YIL084C	SDS3	hom	Verified	1.78618587579557	0.0370345836100126	no	209	0.0442156218003187	254	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|chromatin silencing|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation	histone deacetylase activity	Rpd3L-Expanded complex|Rpd3L complex
YDR287W	YDR287W	INM2	hom	Verified	1.77921073452408	0.0376026095682956	no	210	0.0357730669917255	187	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM			Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy	inositol phosphate dephosphorylation	inositol monophosphate 1-phosphatase activity	cellular_component
YGR189C	YGR189C	CRH1	hom	Verified	1.77858175384634	0.0376541788467247	no	211	0.0265151374734354	130	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress	fungal-type cell wall organization|cell wall chitin metabolic process	transferase activity, transferring glycosyl groups	incipient cellular bud site|fungal-type cell wall
YJR115W_p	YJR115W	YJR115W	hom	Uncharacterized	1.77726517851244	0.037762310002671	no	212	0.0281698740844789	167	NA					Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YBR058C-A	YBR058C-A	TSC3	hom	Verified	1.77081375488083	0.0382958389237243	no	213	0.177926869546279	762	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis	3-keto-sphinganine metabolic process|sphingolipid biosynthetic process	enzyme activator activity	SPOTS complex
YOL029C_p	YOL029C	YOL029C	hom	Uncharacterized	1.76790575832913	0.038538329996459	no	214	0.0349143957105697	194	NA					Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens	biological_process	molecular_function	cellular_component
YOL108C	YOL108C	INO4	hom	Verified	1.76667426726846	0.0386413976460664	no	215	0.0433636605347611	256	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain	phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YBL010C_p	YBL010C	YBL010C	hom	Uncharacterized	1.75964424650788	0.0392340722172234	no	216	0.0379219230572861	225	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles	biological_process	molecular_function	clathrin-coated vesicle
YOL100W	YOL100W	PKH2	hom	Verified	1.75827121833941	0.0393506862248368	no	217	0.0425832906695429	218	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p	regulation of nuclear-transcribed mRNA poly(A) tail shortening|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly	protein kinase activity	cell cortex|eisosome|nucleus
YDL188C	YDL188C	PPH22	hom	Verified	1.75812805327519	0.0393628617371682	no	218	0.0391316004364868	183	NA	FT	CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CHROMOSOME		Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication	actin filament organization|budding cell bud growth|G1/S transition of mitotic cell cycle|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|regulation of translation	protein serine/threonine phosphatase activity	condensed nuclear chromosome, centromeric region
YHR162W	YHR162W	MPC2	hom	Verified	1.75498963175182	0.0396305406275803	no	219	0.0398671181749474	214	NA					Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|integral to mitochondrial inner membrane
YLR210W	YLR210W	CLB4	hom	Verified	1.75477216989685	0.0396491428570698	no	220	0.0395424794661329	166	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|CYTOSKELETON		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation	G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|spindle pole body|cytoplasm
YGL166W	YGL166W	CUP2	hom	Verified	1.752589528426	0.039836245007101	no	221	0.0443803367064382	186	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter|response to copper ion	RNA polymerase II core promoter proximal region sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|copper ion binding	nucleus
YGR133W	YGR133W	PEX4	hom	Verified	1.75181889694885	0.0399024768922316	no	222	0.0274852330998687	156	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis	peroxisome organization|protein import into peroxisome matrix, receptor recycling|protein autoubiquitination|protein monoubiquitination|protein polyubiquitination	ubiquitin-protein ligase activity	peroxisome
YML103C	YML103C	NUP188	hom	Verified	1.75029870237191	0.0400333923589403	no	223	0.0363565249690152	163	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188	nuclear pore organization|protein import into nucleus|mRNA export from nucleus in response to heat stress	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YOR082C_d	YOR082C	YOR082C	hom	Dubious	1.74955685907846	0.040097404701756	no	224	0.0322042489172332	169	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W	Unknown	Unknown	Unknown
YGR292W	YGR292W	MAL12	hom	Verified	1.74945761252483	0.040105974814416	no	225	0.0217391752520133	98	NA	FT	CARBOHYDRATE METABOLISM			Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose	sucrose catabolic process|maltose catabolic process	sucrose alpha-glucosidase activity|maltose alpha-glucosidase activity	plasma membrane
YDR415C_p	YDR415C	YDR415C	hom	Uncharacterized	1.74903723795412	0.0401422913932232	no	226	0.0252985737850309	135	NA	FT	PROTEOLYSIS			Putative aminopeptidase	biological_process	molecular_function	cellular_component
YGR112W	YGR112W	SHY1	hom	Verified	1.74856695524678	0.0401829512431836	no	227	0.0227514121838379	133	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome	mitochondrial respiratory chain complex IV assembly|aerobic respiration	unfolded protein binding	mitochondrion|integral to membrane|mitochondrial inner membrane
YML038C	YML038C	YMD8	hom	Verified	1.74040486056571	0.0408939763300514	no	228	0.0419668409050095	203	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Putative nucleotide sugar transporter, has similarity to Vrg4p	UDP-glucose transport|nucleotide-sugar transport	nucleotide-sugar transmembrane transporter activity	COPI-coated vesicle|integral to membrane
YDL214C	YDL214C	PRR2	hom	Verified	1.73896513547223	0.0410204478523548	no	229	0.0351265089393486	190	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance	negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation	protein kinase activity|receptor signaling protein serine/threonine kinase activity	nucleus
YDR349C	YDR349C	YPS7	hom	Verified	1.73578185040974	0.0413012072238066	no	230	0.0376528097022352	196	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum	fungal-type cell wall organization	aspartic-type endopeptidase activity	endoplasmic reticulum|cytoplasm
YMR121C	YMR121C	RPL15B	hom	Verified	1.73386549356999	0.0414709758302146	no	231	0.0325101888819723	172	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YLR080W	YLR080W	EMP46	hom	Verified	1.73025818953769	0.0417920780154668	no	232	0.0298145250529957	123	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport	ER to Golgi vesicle-mediated transport	glycoprotein binding	ER to Golgi transport vesicle|Golgi membrane
YMR191W	YMR191W	SPG5	hom	Verified	1.71707373444552	0.042982850281129	no	233	0.0487337965725887	207	NA					Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	biological_process	molecular_function	cellular_component
YPL013C	YPL013C	MRPS16	hom	Verified	1.71569927440109	0.0431085488262997	no	234	0.0563069191842816	235	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YDR077W	YDR077W	SED1	hom	Verified	1.711264074515	0.0435161875467856	no	235	0.0370306539300329	208	NA	FT	CELL WALL ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites	fungal-type cell wall organization|mitochondrial genome maintenance	structural constituent of cell wall	mitochondrion|ribosome|fungal-type cell wall
YGR054W	YGR054W	YGR054W	hom	Verified	1.71094325432958	0.0435457943565953	no	236	0.0411597152376554	187	NA	FT	TRANSLATION			Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A	translational initiation	translation initiation factor activity	cytosolic ribosome|cytosolic small ribosomal subunit|ribosome
YDR153C	YDR153C	ENT5	hom	Verified	1.70727097157565	0.0438858494812967	no	237	0.0331767519606102	140	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin	late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|Golgi to endosome transport	clathrin binding|phosphatidylinositol-3,5-bisphosphate binding	endosome|clathrin vesicle coat|cytoplasm
YDR400W	YDR400W	URH1	hom	Verified	1.70210439946008	0.0443678996764416	no	238	0.0352788102177544	152	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways	pyrimidine-containing compound salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|pyrimidine nucleoside catabolic process|nicotinate nucleotide salvage	ribosylpyrimidine nucleosidase activity|nicotinic acid riboside hydrolase activity|nicotinamide riboside hydrolase activity|uridine nucleosidase activity	nucleus|cytoplasm
YDL224C	YDL224C	WHI4	hom	Verified	1.69986086487213	0.0445785498365878	no	239	0.0240801427769583	112	NA					Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication	regulation of cell size	RNA binding	cytoplasm
YNR020C	YNR020C	ATP23	hom	Verified	1.69842851803063	0.044713456723355	no	240	0.0594242102758395	226	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p	protein processing|mitochondrial proton-transporting ATP synthase complex assembly	metalloendopeptidase activity	mitochondrial inner membrane|mitochondrial intermembrane space
YGR200C	YGR200C	ELP2	hom	Verified	1.69701484388453	0.0448469270982246	no	241	0.0607013752424865	274	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin	regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YBR008C	YBR008C	FLR1	hom	Verified	1.69671553698363	0.0448752269115387	no	242	0.0352344934411526	242	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress	drug transmembrane transport|transmembrane transport	fluconazole transporter activity|drug transmembrane transporter activity	integral to membrane|plasma membrane
YLL010C	YLL010C	PSR1	hom	Verified	1.68598048280269	0.0458997793114934	no	243	0.0498335544259365	259	NA	FT		PLASMA MEMBRANE		Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p	response to stress	phosphoprotein phosphatase activity	plasma membrane
YOL047C_p	YOL047C	YOL047C	hom	Uncharacterized	1.6833079961764	0.0461577416361106	no	244	0.0369753584358299	159	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	integral to membrane|cytoplasm
YMR130W_p	YMR130W	YMR130W	hom	Uncharacterized	1.68320964316484	0.0461672573498102	no	245	0.0234768417475109	122	NA					Putative protein of unknown function; YMR130W is not an essential gene	biological_process	molecular_function	cellular_component
YJL071W	YJL071W	ARG2	hom	Verified	1.67506652120763	0.0469605903536827	no	246	0.0360741282032365	214	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p	arginine biosynthetic process|ornithine biosynthetic process	acetyl-CoA:L-glutamate N-acetyltransferase activity	mitochondrial matrix
YOR333C_d	YOR333C	YOR333C	hom	Dubious	1.67120956485609	0.0473401458297181	no	247	0.0343508656884839	149	NA					Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth	Unknown	Unknown	Unknown
YML057W	YML057W	CMP2	hom	Verified	1.67087170893375	0.0473735103346922	no	248	0.0276698923555264	129	NA	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS			Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity	calcineurin complex|cytoplasm
YHR177W_p	YHR177W	YHR177W	hom	Uncharacterized	1.67022055210483	0.0474378675999043	no	249	0.0484151056004758	250	NA					Putative protein of unknown function; overexpression causes a cell cycle delay or arrest	biological_process	molecular_function	cellular_component
YHR003C	YHR003C	YHR003C	hom	Verified	1.67008433294163	0.0474513397144546	no	250	0.0221992523133561	121	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YLR064W	YLR064W	PER33	hom	Verified	1.66849419025156	0.0476088321405689	no	251	0.0420205630817759	210	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	NUCLEAR PORE	Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|endoplasmic reticulum|nuclear pore
YKR082W	YKR082W	NUP133	hom	Verified	1.66819911426974	0.0476381033402299	no	252	0.0515285120782223	269	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133	poly(A)+ mRNA export from nucleus|double-strand break repair|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|tRNA export from nucleus|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore outer ring
YNL043C_d	YNL043C	YNL043C	hom	Dubious	1.66692722703873	0.0477644381000582	no	253	0.0501022447648855	228	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W	Unknown	Unknown	Unknown
YBR276C	YBR276C	PPS1	hom	Verified	1.66660679966287	0.0477963079681763	no	254	0.0262155783385978	123	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle	inactivation of MAPK activity|protein dephosphorylation|regulation of S phase of mitotic cell cycle	protein tyrosine/serine/threonine phosphatase activity	cellular_component
YML116W-A_d	YML116W-A	YML116W-A	hom	Dubious	1.66634969928461	0.0478218916105949	no	255	0.0234223828478035	134	NA					Putative protein of unknown function	Unknown	Unknown	Unknown
YER155C	YER155C	BEM2	hom	Verified	1.66197224417487	0.0482591699038015	no	256	0.0527926769366375	234	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence	negative regulation of Rho protein signal transduction|fungal-type cell wall organization|establishment of cell polarity|actin cytoskeleton organization	Rho GTPase activator activity	cell cortex|incipient cellular bud site|mitochondrion|plasma membrane|mating projection tip|cytoplasm|cellular bud tip
YNL311C	YNL311C	SKP2	hom	Verified	1.6600786588978	0.0484493147703853	no	257	0.0371751267622596	169	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular protein catabolic process|regulation of sulfur amino acid metabolic process	ubiquitin-protein ligase activity|protein binding, bridging	ribosome|SCF ubiquitin ligase complex
YGR149W_p	YGR149W	YGR149W	hom	Uncharacterized	1.6597998017291	0.0484773668300859	no	258	0.0333476992044094	151	NA					Putative protein of unknown function; predicted to be an integal membrane protein	biological_process	molecular_function	integral to membrane
YIL052C	YIL052C	RPL34B	hom	Verified	1.65678885121626	0.0487810859067059	no	259	0.0804411072122197	399	NA	FF|FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YKL128C	YKL128C	PMU1	hom	Verified	1.65524647683596	0.0489372555230999	no	260	0.0272898709291481	148	NA	FT		NUCLEUS		Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant	biological_process	molecular_function	nucleus|cytoplasm
YDR009W	YDR009W	GAL3	hom	Verified	1.65514769218257	0.0489472713350157	no	261	0.0315644627431865	151	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication	maintenance of protein location|galactose metabolic process|positive regulation of transcription from RNA polymerase II promoter by galactose	protein binding	nucleus|cytoplasm
YLR123C_d	YLR123C	YLR123C	hom	Dubious	1.65072618532676	0.0493972492260952	no	262	0.0375966553990873	187	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif	Unknown	Unknown	Unknown
YDR262W_p	YDR262W	YDR262W	hom	Uncharacterized	1.64723063024016	0.0497553251036742	no	263	0.0302886083859593	168	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment	biological_process	molecular_function	fungal-type vacuole
YKL187C	YKL187C	FAT3	hom	Verified	1.64475966165957	0.0500096919195078	no	264	0.0352326983502956	168	NA	FT		MITOCHONDRION		Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|integral to membrane
YDR029W_d	YDR029W	YDR029W	hom	Dubious	1.64302960800355	0.0501884037451524	no	265	0.0349247076761489	169	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR004C	YLR004C	THI73	hom	Verified	1.64182542620241	0.0503130940506407	no	266	0.0379465029749717	152	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs	transport	transporter activity	integral to membrane|endoplasmic reticulum
YKL156W	YKL156W	RPS27A	hom	Verified	1.64080070979638	0.0504193954472415	no	267	0.0582909349670319	203	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasm
YOL048C	YOL048C	RRT8	hom	Verified	1.63904200793429	0.0506022556406476	no	268	0.0470207004490403	199	NA					Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|lipid particle
YNR015W	YNR015W	SMM1	hom	Verified	1.63805109710548	0.0507055175616271	no	269	0.0328146715287991	194	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	NUCLEUS		Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs	tRNA processing|tRNA modification	tRNA dihydrouridine synthase activity	nucleus|cytoplasm
YLR451W	YLR451W	LEU3	hom	Verified	1.63706652575325	0.0508082849917607	no	270	0.0480540747175319	222	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation	negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YOL043C	YOL043C	NTG2	hom	Verified	1.6337665670836	0.0511539374483407	no	271	0.0321954952221504	149	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication	base-excision repair|base-excision repair, AP site formation	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity	nucleus
YBR065C	YBR065C	ECM2	hom	Verified	1.63316929614379	0.0512166978040586	no	272	0.0451854082193101	206	NA	FT	RNA PROCESSING	NUCLEUS		Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p	mRNA splicing, via spliceosome	molecular_function	nucleus
YKL121W_p	YKL121W	DGR2	hom	Uncharacterized	1.63073304828648	0.051473330005021	no	273	0.0537906690583729	240	NA					Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds	biological_process	molecular_function	cellular_component
YGR136W	YGR136W	LSB1	hom	Verified	1.63053411598337	0.0514943304391728	no	274	0.0288911102078207	125	NA	FT		NUCLEUS		Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YLR281C_p	YLR281C	YLR281C	hom	Uncharacterized	1.62932266217218	0.0516223655725236	no	275	0.0408043306170465	189	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene	biological_process	molecular_function	mitochondrion
YJL213W	YJL213W	YJL213W	hom	Verified	1.62428112721931	0.0521579116206233	no	276	0.0423905841106492	204	NA					Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p	biological_process	molecular_function	ribosome
YFL015C_d	YFL015C	YFL015C	hom	Dubious	1.62423396205272	0.0521629425805464	no	277	0.0442959581697916	205	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene	Unknown	Unknown	Unknown
YIR020C_p	YIR020C	YIR020C	hom	Uncharacterized	1.61874685398385	0.0527508706275328	no	278	0.0332696830739509	183	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YNL052W	YNL052W	COX5A	hom	Verified	1.6187362784479	0.052752008821472	no	279	0.0395914671629621	210	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YGL249W	YGL249W	ZIP2	hom	Verified	1.60681042840829	0.05404797995761	no	280	0.033839298621617	160	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	synaptonemal complex assembly|synapsis|reciprocal meiotic recombination	molecular_function	synaptonemal complex
YDR006C	YDR006C	SOK1	hom	Verified	1.60220337355198	0.0545553221611446	no	281	0.0451406805238417	179	NA	FT	SIGNALING	NUCLEUS		Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13	cAMP-mediated signaling	molecular_function	nucleus
YDL018C	YDL018C	ERP3	hom	Verified	1.60171956474034	0.0546088183823189	no	282	0.0682013426862676	232	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YJR091C	YJR091C	JSN1	hom	Verified	1.60070846370488	0.0547207528425981	no	283	0.0343560675752593	171	NA	FT	PROTEIN LOCALIZATION	MITOCHONDRION		Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|cellular protein complex localization|establishment of mitochondrion localization	mRNA binding	external side of mitochondrial outer membrane
YJL101C	YJL101C	GSH1	hom	Verified	1.59945376522603	0.0548599069978922	no	284	0.0437182581467382	214	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS			Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress	response to cadmium ion|response to hydrogen peroxide|glutathione biosynthetic process	glutamate-cysteine ligase activity	intracellular
YOR243C	YOR243C	PUS7	hom	Verified	1.59811661244715	0.0550085135737237	no	285	0.0706882158131931	298	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria	snRNA pseudouridine synthesis|tRNA pseudouridine synthesis|enzyme-directed rRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus
YLR063W_p	YLR063W	YLR063W	hom	Uncharacterized	1.59798682479278	0.0550229546477203	no	286	0.046454275013295	174	NA					Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cytoplasm
YMR025W	YMR025W	CSI1	hom	Verified	1.59485836695942	0.0553719557229592	no	287	0.0475413937773547	197	NA	FT	SIGNALING	NUCLEUS		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	molecular_function	signalosome
YOR184W	YOR184W	SER1	hom	Verified	1.59112346870787	0.0557908959207329	no	288	0.0617444576082068	293	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress	serine family amino acid biosynthetic process|L-serine biosynthetic process|purine nucleobase biosynthetic process	O-phospho-L-serine:2-oxoglutarate aminotransferase activity	cytoplasm
YKL084W	YKL084W	HOT13	hom	Verified	1.58995809641316	0.0559221253873085	no	289	0.058403045060971	244	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc	protein import into mitochondrial intermembrane space	zinc ion binding	mitochondrial intermembrane space
YDR242W	YDR242W	AMD2	hom	Verified	1.58981037791741	0.0559387769477322	no	290	0.0282416134607586	129	NA					Putative amidase	biological_process	amidase activity	cellular_component
YMR311C	YMR311C	GLC8	hom	Verified	1.58504146518765	0.0564784567460021	no	291	0.0645350038946906	322	NA	FT	SIGNALING|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION	NUCLEUS		Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress	chromosome segregation|glycogen biosynthetic process	enzyme activator activity	nucleus|cytoplasm
YDR285W	YDR285W	ZIP1	hom	Verified	1.58414448548562	0.0565804215099155	no	292	0.060064303192769	267	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate	synapsis|reciprocal meiotic recombination	chromatin binding|SUMO polymer binding	transverse filament
YKL205W	YKL205W	LOS1	hom	Verified	1.58341727507719	0.0566631940543493	no	293	0.0591127862447249	214	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS|MITOCHONDRION		Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus	tRNA binding|Ran GTPase binding	mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YLL009C	YLL009C	COX17	hom	Verified	1.58229829615659	0.0567907447669	no	294	0.0475467406942163	195	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex IV assembly|intracellular copper ion transport	copper chaperone activity	cytosol|mitochondrion|mitochondrial intermembrane space
YHR132C	YHR132C	ECM14	hom	Verified	1.57883859650421	0.0571865415738634	no	295	0.0577252852319982	257	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS			Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly	fungal-type cell wall organization|proteolysis	metalloendopeptidase activity	fungal-type vacuole
YGL154C	YGL154C	LYS5	hom	Verified	1.57586188841371	0.0575288179143011	no	296	0.041044964978377	187	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine	lysine biosynthetic process via aminoadipic acid|protein-cofactor linkage	holo-[acyl-carrier-protein] synthase activity	cytoplasm
YGL184C	YGL184C	STR3	hom	Verified	1.57573901560824	0.0575429809812024	no	297	0.0606658023972155	265	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p	methionine biosynthetic process|transsulfuration	cystathionine beta-lyase activity	peroxisome
YNR005C_d	YNR005C	YNR005C	hom	Dubious	1.57505272859571	0.057622137041037	no	298	0.0774024830740106	352	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR019C	YJR019C	TES1	hom	Verified	1.5741198791205	0.057729868793068	no	299	0.0535739674554475	201	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids	fatty acid beta-oxidation|fatty acid oxidation	acyl-CoA hydrolase activity	mitochondrion|peroxisome
YHL038C	YHL038C	CBP2	hom	Verified	1.57406189459391	0.0577365704620615	no	300	0.0366791679160174	188	NA	FT	RNA PROCESSING	MITOCHONDRION		Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene	Group I intron splicing	RNA binding	mitochondrion
YHR175W-A_p	YHR175W-A	YHR175W-A	hom	Uncharacterized	1.57316868004481	0.0578398826947526	no	301	0.0420899193593691	204	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YBR089C-A	YBR089C-A	NHP6B	hom	Verified	1.56960670656307	0.0582533186513664	no	302	0.0398698483934182	198	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication	RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling|transcription from RNA polymerase II promoter	nucleosome binding|DNA binding, bending|sequence-specific DNA binding	nucleus
YER071C_p	YER071C	TDA2	hom	Uncharacterized	1.56895591095677	0.0583291062902308	no	303	0.046144165300136	174	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	mating projection tip|cytoplasm
YJL157C	YJL157C	FAR1	hom	Verified	1.56675563980107	0.0585859099386833	no	304	0.0306227326059171	174	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH		Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress	maintenance of protein location in nucleus|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell cycle arrest in response to pheromone	cyclin-dependent protein kinase inhibitor activity	nucleus|mating projection tip|membrane|cytoplasm
YNL301C	YNL301C	RPL18B	hom	Verified	1.56302226694923	0.0590236787504051	no	305	0.0445814607787972	216	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YML119W_p	YML119W	YML119W	hom	Uncharacterized	1.55841699578327	0.0595672151537752	no	306	0.0552795658022755	185	NA					Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate	biological_process	molecular_function	cellular_component
YKL061W_p	YKL061W	BLI1	hom	Uncharacterized	1.55802453020115	0.0596137166434163	no	307	0.0488282947684201	210	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YGL180W	YGL180W	ATG1	hom	Verified	1.55699937277157	0.0597353171650569	no	308	0.052153435804791	239	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p	piecemeal microautophagy of nucleus|mitochondrion degradation|protein phosphorylation|CVT pathway|autophagic vacuole assembly	protein serine/threonine kinase activity|protein kinase activity	cytosol|pre-autophagosomal structure|Atg1p signaling complex
YMR193C-A_d	YMR193C-A	YMR193C-A	hom	Dubious	1.5569427448726	0.0597420398243638	no	309	0.04373023373795	217	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR078C	YGR078C	PAC10	hom	Verified	1.55470885909161	0.060007711873422	no	310	0.0904636060780066	386	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding	tubulin complex assembly	tubulin binding	prefoldin complex|polysome|cytoplasm
YCR068W	YCR068W	ATG15	hom	Verified	1.55398485611303	0.0600940144908723	no	311	0.0793214013006039	360	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway	membrane disassembly|autophagy|piecemeal microautophagy of nucleus|vacuolar protein processing|multivesicular body membrane disassembly	lipase activity	integral to membrane|vacuolar lumen
YOL052C	YOL052C	SPE2	hom	Verified	1.55288186369709	0.0602256801837019	no	312	0.070871236393035	228	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically	spermidine biosynthetic process|spermine biosynthetic process|pantothenate biosynthetic process	adenosylmethionine decarboxylase activity	nucleus|cytoplasm
YOL079W_d	YOL079W	YOL079W	hom	Dubious	1.55167971995811	0.0603694387708331	no	313	0.0736353863244557	250	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR227C	YLR227C	ADY4	hom	Verified	1.54275565281683	0.0614450365791317	no	314	0.046810201361349	216	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CYTOSKELETON		Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane	sporulation resulting in formation of a cellular spore	structural molecule activity	spindle pole body
YHR073W	YHR073W	OSH3	hom	Verified	1.54136895891376	0.0616135071710098	no	315	0.0618377943609642	321	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	karyogamy involved in conjugation with cellular fusion|endocytosis|exocytosis|positive regulation of phosphatase activity|maintenance of cell polarity|pseudohyphal growth|sterol transport|invasive growth in response to glucose limitation	lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity	cortical endoplasmic reticulum|cytoplasm
YDR107C	YDR107C	TMN2	hom	Verified	1.54073694806441	0.0616904102525409	no	316	0.0315037444380645	127	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments	cellular copper ion homeostasis|pseudohyphal growth|vacuolar transport|invasive growth in response to glucose limitation	molecular_function	fungal-type vacuole membrane|integral to membrane
YER106W	YER106W	MAM1	hom	Verified	1.53869130075471	0.0619398385439238	no	317	0.0537835066494152	308	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle	meiotic chromosome segregation|meiotic sister chromatid cohesion involved in meiosis I	molecular_function	condensed nuclear chromosome kinetochore|monopolin complex
YFL048C	YFL048C	EMP47	hom	Verified	1.53804487318367	0.062018821688081	no	318	0.0580846251382645	264	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport	ER to Golgi vesicle-mediated transport	glycoprotein binding	fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YMR019W	YMR019W	STB4	hom	Verified	1.53791373627453	0.0620348541122511	no	319	0.0499634826087366	186	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;	biological_process	sequence-specific DNA binding|DNA binding	nucleus
YDL204W	YDL204W	RTN2	hom	Verified	1.53522119323532	0.0623647521020379	no	320	0.0841409049491601	333	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication	endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network maintenance	molecular_function	endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YHL006C	YHL006C	SHU1	hom	Verified	1.53403282926721	0.0625107882731205	no	321	0.0304533533611487	180	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function	recombinational repair|maintenance of rDNA	molecular_function	nucleolus|Shu complex
YMR271C	YMR271C	URA10	hom	Verified	1.52789671430151	0.06326909206635	no	322	0.0495552934031258	254	NA	FT	NUCLEOTIDE METABOLISM			Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication	'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process	orotate phosphoribosyltransferase activity	cytoplasm
YGL109W_d	YGL109W	YGL109W	hom	Dubious	1.5147480512955	0.0649181103314565	no	323	0.0383738574882491	181	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C	Unknown	Unknown	Unknown
YLL015W	YLL015W	BPT1	hom	Verified	1.51280181819414	0.0651650034277834	no	324	0.0523303876049128	179	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p	cadmium ion transport|bilirubin transport	bilirubin transmembrane transporter activity|cadmium ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YNL099C	YNL099C	OCA1	hom	Verified	1.51042152848379	0.0654679493548178	no	325	0.0768329473951961	362	NA	FF|FT	RESPONSE TO OXIDATIVE STRESS			Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA	cellular response to oxidative stress	protein tyrosine phosphatase activity	cytoplasm
YBR216C	YBR216C	YBP1	hom	Verified	1.50854990296697	0.065706922380668	no	326	0.0591953667747471	207	NA	FT	RESPONSE TO OXIDATIVE STRESS			Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication	cellular response to oxidative stress	molecular_function	cytoplasm
YBR076W	YBR076W	ECM8	hom	Verified	1.50825727599429	0.0657443466514033	no	327	0.0701748778251124	246	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function	fungal-type cell wall organization	molecular_function	cellular_component
YJL136W-A_p	YJL136W-A	YJL136W-A	hom	Uncharacterized	1.50744060848992	0.0658488782418348	no	328	0.0417386064777167	161	NA					Putative protein of unknown function; identified by SAGE	biological_process	molecular_function	cellular_component
YCL024W	YCL024W	KCC4	hom	Verified	1.50319718614639	0.06639410147038	no	329	0.0645478004078662	277	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication	budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly	phosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|protein kinase activity	incipient cellular bud site|cellular bud neck septin collar|plasma membrane|cellular bud neck|septin ring
YBR291C	YBR291C	CTP1	hom	Verified	1.50185039523253	0.0665678749538282	no	330	0.0717407419631049	374	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family	mitochondrial citrate transport|transmembrane transport	tricarboxylate secondary active transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YGL009C	YGL009C	LEU1	hom	Verified	1.49979994457981	0.0668331158537789	no	331	0.0649841609154575	238	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway	leucine biosynthetic process	3-isopropylmalate dehydratase activity	cytosol
YDL133C-A	YDL133C-A	RPL41B	hom	Verified	1.49560143486741	0.0673787745123279	no	332	0.0544293047195262	244	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YKL017C	YKL017C	HCS1	hom	Verified	1.49492989592791	0.0674663695008866	no	333	0.0479345920383983	247	NA	FT		NUCLEUS|CHROMOSOME		Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities	lagging strand elongation	ATP-dependent 5'-3' DNA helicase activity	DNA helicase A complex|alpha DNA polymerase:primase complex
YMR012W	YMR012W	CLU1	hom	Verified	1.49364855074337	0.0676337512522833	no	334	0.0592596887705726	253	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION			eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant	translational initiation|mitochondrion organization	molecular_function	eukaryotic translation initiation factor 3 complex|cytoplasm
YML106W	YML106W	URA5	hom	Verified	1.49307724005799	0.0677084847397211	no	335	0.0636978662841341	269	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication	'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process	orotate phosphoribosyltransferase activity	nucleus|cytoplasm
YLR346C_p	YLR346C	YLR346C	hom	Uncharacterized	1.49299522623728	0.0677192182499928	no	336	0.0459952846518917	193	NA	FT		MITOCHONDRION		Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene	biological_process	molecular_function	mitochondrion
YPL101W	YPL101W	ELP4	hom	Verified	1.48985309609915	0.0681314333057028	no	337	0.0941677491952501	373	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex|cytoplasm
YDR352W	YDR352W	YPQ2	hom	Verified	1.48802555046529	0.068372077782403	no	338	0.0470992949441041	194	NA					Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YHR153C	YHR153C	SPO16	hom	Verified	1.48783237453524	0.0683975527548709	no	339	0.0497939944526298	228	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation	synaptonemal complex assembly|ascospore formation|regulation of reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YGL216W	YGL216W	KIP3	hom	Verified	1.48504794514735	0.0687655619508156	no	340	0.0486729936316834	229	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Kinesin-related motor protein involved in mitotic spindle positioning	nuclear migration along microtubule|mitotic spindle disassembly|establishment of mitotic spindle orientation|plus-end specific microtubule depolymerization|mitotic spindle organization in nucleus	plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity	kinesin complex|cytoplasmic microtubule|nuclear microtubule
YNR049C	YNR049C	MSO1	hom	Verified	1.48475463473558	0.0688044165722185	no	341	0.0675432910609316	302	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress	cellular membrane fusion|ascospore-type prospore membrane assembly|vesicle docking involved in exocytosis	molecular_function	SNARE complex|cellular bud membrane|plasma membrane|prospore membrane|cellular bud neck|cellular bud tip
YNR033W	YNR033W	ABZ1	hom	Verified	1.48451759372753	0.0688358295913711	no	342	0.0483191227604233	216	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress	para-aminobenzoic acid biosynthetic process	4-amino-4-deoxychorismate synthase activity	cytoplasm
YMR258C	YMR258C	ROY1	hom	Verified	1.48307919073742	0.0690266860229893	no	343	0.0724880243785635	342	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|NUCLEUS		GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p	endocytosis|protein targeting to vacuole|negative regulation of GTPase activity	GTPase inhibitor activity	nucleus|cytoplasm
YNL106C	YNL106C	INP52	hom	Verified	1.48211454271222	0.069154909938139	no	344	0.0415727068943711	205	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity	mating projection tip|cytoplasm|actin cortical patch
YDR402C	YDR402C	DIT2	hom	Verified	1.47798410304673	0.0697060166450427	no	345	0.0769041502424881	267	NA	FT	CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS			N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s	ascospore wall assembly	oxidoreductase activity	cellular_component
YOL004W	YOL004W	SIN3	hom	Verified	1.47702400726463	0.0698346010386347	no	346	0.0697111111464651	356	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL DIVISION|GENE SILENCING	NUCLEUS|CHROMOSOME		Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of transcription during meiosis|regulation of DNA-dependent DNA replication initiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|double-strand break repair via nonhomologous end joining|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle	transcription coactivator activity|transcription corepressor activity	Sin3-type complex|Rpd3S complex|Rpd3L-Expanded complex|Rpd3L complex
YPL110C	YPL110C	GDE1	hom	Verified	1.47627617161907	0.0699348841179131	no	347	0.0700331315077185	291	NA	FT	LIPID METABOLISM|SIGNALING|CARBOHYDRATE METABOLISM			Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes	glycerophospholipid catabolic process	glycerophosphocholine phosphodiesterase activity	ribosome|cytoplasm
YDL121C_p	YDL121C	YDL121C	hom	Uncharacterized	1.47441030505207	0.0701855757617735	no	348	0.0499257174214747	206	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein	biological_process	molecular_function	endoplasmic reticulum
YPL036W	YPL036W	PMA2	hom	Verified	1.46926976878388	0.0708798165720276	no	349	0.048087627998572	174	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential	proton transport|regulation of pH	hydrogen-exporting ATPase activity, phosphorylative mechanism	mitochondrion|integral to membrane|plasma membrane
YDR099W	YDR099W	BMH2	hom	Verified	1.46897784509931	0.0709193992463246	no	350	0.0795632868589291	273	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	glycogen metabolic process|ascospore formation|Ras protein signal transduction|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|DNA damage checkpoint|DNA replication initiation|signal transduction involved in filamentous growth|pseudohyphal growth|fungal-type cell wall chitin biosynthetic process|pre-replicative complex assembly	DNA replication origin binding|phosphoserine binding	nucleus|plasma membrane
YDL167C	YDL167C	NRP1	hom	Verified	1.46786682801265	0.0710702001753298	no	351	0.0800638326034046	325	NA					Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	cytoplasmic stress granule|cytoplasm
YJR147W	YJR147W	HMS2	hom	Verified	1.4642566119433	0.0715619236475307	no	352	0.0507788612372978	188	NA	FT		NUCLEUS		Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication	pseudohyphal growth	molecular_function	nucleus|cytoplasm
YDR198C	YDR198C	RKM2	hom	Verified	1.46388315452671	0.0716129384149582	no	353	0.0840735096856406	283	NA					Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp	peptidyl-lysine trimethylation|peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	cellular_component
YGL160W	YGL160W	AIM14	hom	Verified	1.46285218234843	0.0717539153857489	no	354	0.0695015261221332	297	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p	biological_process	oxidoreductase activity, oxidizing metal ions	integral to membrane|ribosome
YBR003W	YBR003W	COQ1	hom	Verified	1.46267481131453	0.0717781908641051	no	355	0.0843372262836284	367	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis	ubiquinone biosynthetic process	trans-hexaprenyltranstransferase activity	mitochondrion
YDL225W	YDL225W	SHS1	hom	Verified	1.46265797920499	0.0717804948792566	no	356	0.0470427640092178	242	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress	cytokinesis, actomyosin contractile ring assembly|G1 phase of mitotic cell cycle|barrier septum assembly|exit from mitosis|cell cycle cytokinesis|septin ring assembly|cellular bud neck septin ring organization	GTP binding	cellular bud neck septin ring|mating projection tip
YBR186W	YBR186W	PCH2	hom	Verified	1.4603418217714	0.072098076720891	no	357	0.0437125471638442	183	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation	meiotic recombination checkpoint|meiotic DNA double-strand break formation|reciprocal meiotic recombination	ATPase activity	nucleolus
YBR083W	YBR083W	TEC1	hom	Verified	1.46014458959543	0.0721251700611768	no	358	0.0440914331185565	221	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member	pseudohyphal growth|chronological cell aging|positive regulation of transposition, RNA-mediated|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YPL189C-A	YPL189C-A	COA2	hom	Verified	1.45829385002356	0.0723797823288332	no	359	0.0666142488619736	249	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrial matrix
YGR213C	YGR213C	RTA1	hom	Verified	1.45761829034195	0.0724728926502737	no	360	0.0500333213303459	217	NA	FT		PLASMA MEMBRANE		Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein	biological_process	molecular_function	integral to membrane|plasma membrane
YLR219W	YLR219W	MSC3	hom	Verified	1.45699755523498	0.072558527534491	no	361	0.0477987254082279	240	NA	FT	CELL CYCLE	PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress	reciprocal meiotic recombination	molecular_function	cellular_component
YDR247W	YDR247W	VHS1	hom	Verified	1.45407634821784	0.0729625700575369	no	362	0.0492525868815851	268	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION			Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p	protein phosphorylation|G1/S transition of mitotic cell cycle	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YOR189W	YOR189W	IES4	hom	Verified	1.45380670073001	0.0729999526067594	no	363	0.0775697366722702	311	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses	response to DNA damage stimulus	molecular_function	nucleus|Ino80 complex
YGR209C	YGR209C	TRX2	hom	Verified	1.45373749692767	0.0730095490316089	no	364	0.0547550165749837	200	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress	vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|sulfate assimilation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic	disulfide oxidoreductase activity	cytosol|fungal-type vacuole
YPL111W	YPL111W	CAR1	hom	Verified	1.45344732511446	0.0730497973904498	no	365	0.0812463956665845	383	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|SITE OF POLARIZED GROWTH		Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance	regulation of ornithine metabolic process|arginine catabolic process to ornithine	manganese ion binding|arginase activity|ornithine carbamoyltransferase inhibitor activity|zinc ion binding	cytosol|nucleus|mating projection tip|cytoplasm
YHR086W	YHR086W	NAM8	hom	Verified	1.45204308500435	0.0732448128492232	no	366	0.0703904998901223	284	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS|MITOCHONDRION		RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function	mRNA splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|mRNA splice site selection	mRNA binding|RNA binding	commitment complex|U1 snRNP|U2-type prespliceosome
YGR177C	YGR177C	ATF2	hom	Verified	1.45151350165474	0.0733184626868184	no	367	0.0576922869593354	236	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking	steroid metabolic process|response to toxin|Unknown|sterol acetylation	alcohol O-acetyltransferase activity	integral to endoplasmic reticulum membrane|endoplasmic reticulum|cytoplasm
YDR368W	YDR368W	YPR1	hom	Verified	1.45144933078913	0.073327390858341	no	368	0.0694248739975566	287	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YOR185C	YOR185C	GSP2	hom	Verified	1.44941979066074	0.0736101925617548	no	369	0.086681157649546	356	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM	NUCLEUS		GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress	nucleus organization	GTPase activity	integral to membrane|nucleus
YMR242W-A_p	YMR242W-A	YMR242W-A	hom	Uncharacterized	1.44933498452283	0.0736220278072087	no	370	0.0715802870459223	317	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBL103C	YBL103C	RTG3	hom	Verified	1.44789383751722	0.0738233716914628	no	371	0.0668045410161819	267	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways	mitochondrion degradation|cellular response to oleic acid|mitochondria-nucleus signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription factor import into nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus|cytoplasm
YHR071W	YHR071W	PCL5	hom	Verified	1.44705145677493	0.0739412561602859	no	372	0.0468432598323894	239	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity	negative regulation of sequence-specific DNA binding transcription factor activity|regulation of protein stability|negative regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YGL076C	YGL076C	RPL7A	hom	Verified	1.44563760262178	0.0741394370116853	no	373	0.0706459793673488	280	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit|cytoplasm
YDL219W	YDL219W	DTD1	hom	Verified	1.44562974596031	0.0741405394174753	no	374	0.0614845969049655	262	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes	Unknown	D-leucyl-tRNA(Leu) deacylase activity|D-tyrosyl-tRNA(Tyr) deacylase activity	cytoplasm
YMR274C	YMR274C	RCE1	hom	Verified	1.44410882903228	0.074354182464275	no	375	0.0833145483937675	351	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone	CAAX-box protein processing|peptide pheromone maturation|protein processing	metalloendopeptidase activity	integral to endoplasmic reticulum membrane|integral to membrane
YKR030W	YKR030W	GMH1	hom	Verified	1.44164965961783	0.0747006158038941	no	376	0.0573838094341231	278	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting	transport	molecular_function	integral to membrane|integral to Golgi membrane
YER067W	YER067W	RGI1	hom	Verified	1.43923349301613	0.0750421894379276	no	377	0.0539826918493171	200	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|PLASMA MEMBRANE		Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress	energy reserve metabolic process	molecular_function	cell periphery|nucleus|cytoplasm
YMR172W	YMR172W	HOT1	hom	Verified	1.43813854754408	0.0751973736120305	no	378	0.0564439897357435	260	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p	cellular hyperosmotic salinity response|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YBR149W	YBR149W	ARA1	hom	Verified	1.43652159059324	0.0754269886033591	no	379	0.0662009506128082	255	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM			NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product	cellular carbohydrate metabolic process	alditol:NADP+ 1-oxidoreductase activity|D-arabinose 1-dehydrogenase [NAD(P)+] activity	cytosol
YPR069C	YPR069C	SPE3	hom	Verified	1.43577559529158	0.0755331031779854	no	380	0.0991868176960021	403	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells	spermidine biosynthetic process|pantothenate biosynthetic process	spermidine synthase activity	nucleus|cytoplasm
YGR086C	YGR086C	PIL1	hom	Verified	1.43536677350215	0.0755913045250476	no	381	0.064294155499054	286	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Primary protein component of eisosomes; eisosomes are large immobile cell cortex structures associated with endocytosis; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress	eisosome assembly|endocytosis|negative regulation of protein kinase activity|response to heat|protein localization	lipid binding	mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YDR523C	YDR523C	SPS1	hom	Verified	1.43400616316577	0.0757852520382648	no	382	0.0381190136501018	193	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis	ascospore wall assembly|ascospore formation|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	nucleus|prospore membrane|cytoplasm
YKL197C	YKL197C	PEX1	hom	Verified	1.43248997069003	0.0760018231768437	no	383	0.0719068980996882	303	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis	protein import into peroxisome matrix, receptor recycling	ATPase activity|protein heterodimerization activity	peroxisomal membrane|peroxisome
YLR365W_d	YLR365W	YLR365W	hom	Dubious	1.43186296267341	0.0760915218605342	no	384	0.0505412310787117	209	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene	Unknown	Unknown	Unknown
YGR193C	YGR193C	PDX1	hom	Verified	1.43155641157535	0.0761354058528119	no	385	0.0542373130265857	213	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core	acetyl-CoA biosynthetic process from pyruvate	structural molecule activity	mitochondrion|mitochondrial pyruvate dehydrogenase complex
YNL020C	YNL020C	ARK1	hom	Verified	1.43029810361822	0.0763157394284693	no	386	0.0644794433691039	283	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication	regulation of endocytosis|actin filament organization|protein phosphorylation|cytokinesis|actin cortical patch assembly	protein serine/threonine kinase activity|protein kinase activity	mating projection tip|actin cortical patch
YNL333W	YNL333W	SNZ2	hom	Verified	1.42874442117621	0.0765388526166935	no	387	0.0765447002795278	300	NA	FT	COFACTOR METABOLISM			Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p	pyridoxine metabolic process|thiamine biosynthetic process	protein binding	cellular_component
YDR307W_p	YDR307W	PMT7	hom	Uncharacterized	1.42721684783161	0.0767586998536235	no	388	0.0700675574342669	292	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YMR020W	YMR020W	FMS1	hom	Verified	1.42563574158874	0.0769867568592071	no	389	0.0487635605794635	229	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis	pantothenate biosynthetic process|polyamine catabolic process	polyamine oxidase activity	cytoplasm
YAL044C	YAL044C	GCV3	hom	Verified	1.42138668524228	0.0776021875621576	no	390	0.10903521274797	475	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF	glycine catabolic process|one-carbon metabolic process|protein lipoylation	glycine dehydrogenase (decarboxylating) activity	mitochondrion|glycine cleavage complex
YGR146C-A_p	YGR146C-A	YGR146C-A	hom	Uncharacterized	1.41648881003365	0.0783162190578972	no	391	0.0761756294045316	273	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGR207C	YGR207C	CIR1	hom	Verified	1.41446545929565	0.0786126410464079	no	392	0.0499056708655093	170	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YDL134C	YDL134C	PPH21	hom	Verified	1.41367225733439	0.0787290773058716	no	393	0.0599038376838632	280	NA	FT	CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION			Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication	actin filament organization|budding cell bud growth|protein dephosphorylation|G1/S transition of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|regulation of translation	protein serine/threonine phosphatase activity	protein phosphatase type 2A complex
YGR276C	YGR276C	RNH70	hom	Verified	1.4128527479229	0.0788495125152212	no	394	0.0762495692422353	300	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts	U5 snRNA 3'-end processing|generation of mature 3'-end of 5S rRNA generated by RNA polymerase III|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|tRNA 3'-trailer cleavage, exonucleolytic	3'-5'-exoribonuclease activity|3'-5' exonuclease activity	nucleus
YPL270W	YPL270W	MDL2	hom	Verified	1.41048344389247	0.0791984908441347	no	395	0.0913871098787666	352	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis	oligopeptide transport|oligopeptide export from mitochondrion	oligopeptide-transporting ATPase activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YBL019W	YBL019W	APN2	hom	Verified	1.40709104779079	0.0797001961726199	no	396	0.0539338257240652	175	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII	base-excision repair	DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity	nucleus
YDR055W	YDR055W	PST1	hom	Verified	1.40659850693065	0.0797732380387092	no	397	0.0805215703039332	294	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1	fungal-type cell wall organization	molecular_function	fungal-type cell wall|plasma membrane
YGR165W	YGR165W	MRPS35	hom	Verified	1.40588759884235	0.0798787521685304	no	398	0.118736944348853	461	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YBR272C	YBR272C	HSM3	hom	Verified	1.40507444365374	0.0799995713449807	no	399	0.068572721254551	262	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation	mismatch repair|proteasome regulatory particle assembly	molecular_function	cytosol|proteasome regulatory particle, base subcomplex|nucleus|cytoplasm
YDR294C	YDR294C	DPL1	hom	Verified	1.40493223903045	0.0800207143961676	no	400	0.0610558519903878	216	NA	FT	KETONE METABOLISM|LIPID METABOLISM|SIGNALING|RESPONSE TO NUTRIENT LEVELS	ENDOPLASMIC RETICULUM		Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate	calcium-mediated signaling|sphingolipid metabolic process|cellular response to starvation	sphinganine-1-phosphate aldolase activity	endoplasmic reticulum|cortical endoplasmic reticulum|perinuclear endoplasmic reticulum
YIL114C	YIL114C	POR2	hom	Verified	1.40366039710361	0.0802100003628291	no	401	0.0785277679517912	271	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication	DNA transport|ion transport|cell redox homeostasis	voltage-gated anion channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane
YGR143W	YGR143W	SKN1	hom	Verified	1.39852903241915	0.0809771303383932	no	402	0.102645833304522	359	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p	fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process|sphingolipid biosynthetic process	glucosidase activity	integral to membrane
YNL155W	YNL155W	YNL155W	hom	Verified	1.39696052896365	0.0812127204687257	no	403	0.0646915865338267	300	NA	FT		NUCLEUS		Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YDL199C_p	YDL199C	YDL199C	hom	Uncharacterized	1.39405888992618	0.0816499110296551	no	404	0.0624860252978796	248	NA					Putative transporter, member of the sugar porter family	transport|transmembrane transport	substrate-specific transmembrane transporter activity	integral to membrane|membrane
YPL230W	YPL230W	USV1	hom	Verified	1.39321799048542	0.0817769405528239	no	405	0.0622415076127232	268	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to salt stress	sequence-specific DNA binding	nucleus
YMR058W	YMR058W	FET3	hom	Verified	1.39320706575778	0.0817785918641298	no	406	0.0922927159189476	386	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress	iron assimilation by reduction and transport|high-affinity iron ion transport|response to copper ion	ferroxidase activity|iron ion transmembrane transporter activity	integral to membrane|high affinity iron permease complex|plasma membrane
YER034W	YER034W	YER034W	hom	Verified	1.39276205894165	0.081845877587386	no	407	0.0916108773759249	352	NA	FT		NUCLEUS		Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YEL056W	YEL056W	HAT2	hom	Verified	1.38675719705204	0.0827579064976442	no	408	0.0637501202355677	287	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing	histone acetylation|chromatin assembly or disassembly|chromatin silencing at telomere	histone acetyltransferase activity|histone binding	histone acetyltransferase complex|nucleus|cytoplasm
YLR280C_d	YLR280C	YLR280C	hom	Dubious	1.38511560928501	0.0830085598495471	no	409	0.0650292846921374	225	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR008W	YJR008W	MHO1	hom	Verified	1.38403036270482	0.0831745789488912	no	410	0.0759002582190178	310	NA	FT		NUCLEUS		Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility	biological_process	molecular_function	nucleus|cytoplasm
YJL180C	YJL180C	ATP12	hom	Verified	1.38353984348338	0.0832496995874872	no	411	0.0890352815208153	379	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency	mitochondrial proton-transporting ATP synthase complex assembly	protein domain specific binding	mitochondrion
YBR184W_p	YBR184W	YBR184W	hom	Uncharacterized	1.37654051100207	0.0843271770781472	no	412	0.082070274902107	347	NA					Putative protein of unknown function; YBR184W is not an essential gene	biological_process	molecular_function	cellular_component
YDR261C	YDR261C	EXG2	hom	Verified	1.37590492257653	0.0844255355049509	no	413	0.0708916230402102	317	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	fungal-type cell wall organization	glucan exo-1,3-beta-glucosidase activity	fungal-type cell wall
YAL045C_d	YAL045C	YAL045C	hom	Dubious	1.37289539873343	0.0848924336154409	no	414	0.0651299922235823	251	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A	Unknown	Unknown	Unknown
YGR023W	YGR023W	MTL1	hom	Verified	1.37172021702184	0.0850752761326454	no	415	0.0783870164648357	252	NA	FT	CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	PLASMA MEMBRANE		Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p	cellular response to glucose starvation|fungal-type cell wall organization|cellular response to oxidative stress	molecular_function	integral to plasma membrane
YEL009C	YEL009C	GCN4	hom	Verified	1.37107242026799	0.0851761907257709	no	416	0.203544704428167	767	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels	nitrogen catabolite activation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription initiation from RNA polymerase II promoter|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels	chromatin binding|TFIID-class binding transcription factor activity|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding transcription factor activity	nucleus
YHR001W	YHR001W	OSH7	hom	Verified	1.3708864534006	0.0852051774426243	no	417	0.0618358231191247	252	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	maintenance of cell polarity|endocytosis|exocytosis|sterol transport|sterol metabolic process|late endosome to vacuole transport	lipid binding|oxysterol binding	integral to membrane|cortical endoplasmic reticulum|cytoplasm
YBL052C	YBL052C	SAS3	hom	Verified	1.36725781255348	0.0857722550276955	no	418	0.0948489074267306	372	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal	histone acetylation|chromatin modification|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	histone acetyltransferase activity	NuA3 histone acetyltransferase complex
YJR124C_p	YJR124C	YJR124C	hom	Uncharacterized	1.3670431558301	0.085805889495273	no	419	0.0633824070133166	283	NA					Putative protein of unknown function; expression induced under calcium shortage	biological_process	molecular_function	integral to membrane
YDL068W_d	YDL068W	YDL068W	hom	Dubious	1.36587610950407	0.0859889262320928	no	420	0.109777699394117	413	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL141W	YOL141W	PPM2	hom	Verified	1.36501947778699	0.0861234641054692	no	421	0.0547202340651187	186	NA	FT	RNA PROCESSING	MITOCHONDRION		AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p	tRNA methylation|wybutosine biosynthetic process	tRNA methyltransferase activity	mitochondrion|cytoplasm
YLR233C	YLR233C	EST1	hom	Verified	1.36441774321021	0.0862180633492909	no	422	0.0693455394542182	250	NA	FT		NUCLEUS|CHROMOSOME		TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA	telomere maintenance via telomerase|telomere maintenance|G-quadruplex DNA formation	single-stranded DNA binding|RNA binding|telomeric DNA binding	nucleolus|nucleus|telomerase holoenzyme complex
YPL057C	YPL057C	SUR1	hom	Verified	1.36430771598981	0.0862353692310825	no	423	0.0747941271993328	356	NA	FT	LIPID METABOLISM			Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication	glycosphingolipid biosynthetic process|mannosyl-inositol phosphorylceramide metabolic process|sphingolipid biosynthetic process	mannosyltransferase activity|transferase activity, transferring glycosyl groups	integral to membrane|intracellular
YOL027C	YOL027C	MDM38	hom	Verified	1.36398055350759	0.0862868430750982	no	424	0.0960670456758562	358	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome	potassium ion transport|mitochondrial respiratory chain complex III biogenesis|cellular potassium ion homeostasis|proton transport|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis|protein insertion into mitochondrial membrane	ribosome binding	mitochondrion|mitochondrial inner membrane
YDR395W	YDR395W	SXM1	hom	Verified	1.36330078235272	0.0863938677861607	no	425	0.0874992538816549	354	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1	mRNA export from nucleus|nucleocytoplasmic transport	protein transporter activity	integral to membrane|nucleus|cytoplasm
YOR069W	YOR069W	VPS5	hom	Verified	1.36287903650947	0.0864603182847238	no	426	0.100972067284192	385	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity|phosphatidylinositol-3-phosphate binding	cytosol|endosome|retromer complex, outer shell|retromer complex
YBL063W	YBL063W	KIP1	hom	Verified	1.36258685995988	0.0865063761785777	no	427	0.0649373046537525	209	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions	mitotic anaphase B|microtubule depolymerization|spindle pole body separation|plasmid partitioning|mitotic sister chromatid segregation	microtubule motor activity|structural constituent of cytoskeleton	spindle microtubule|kinesin complex|spindle pole body
YMR135W-A_d	YMR135W-A	YMR135W-A	hom	Dubious	1.36096240501593	0.0867627852502322	no	428	0.0595648662166278	225	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR269W	YOR269W	PAC1	hom	Verified	1.35995076332745	0.0869227526701122	no	429	0.0510949497700169	225	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CYTOSKELETON		Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly	nuclear migration along microtubule	microtubule plus-end binding	cytoplasmic microtubule|nucleus|cytoplasm
YER068C-A_d	YER068C-A	YER068C-A	hom	Dubious	1.35994604576058	0.08692349915852	no	430	0.0798054379845461	262	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL212W	YGL212W	VAM7	hom	Verified	1.35948595631937	0.0869963248341708	no	431	0.0989978729862281	410	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress	piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle fusion	SNAP receptor activity|phosphatidylinositol-3-phosphate binding	SNARE complex|fungal-type vacuole membrane
YDL025C	YDL025C	RTK1	hom	Verified	1.35947539329885	0.086997997346502	no	432	0.126148180217021	433	NA	FT	PROTEIN PHOSPHORYLATION			Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress	biological_process	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YDR419W	YDR419W	RAD30	hom	Verified	1.35909729591271	0.0870578798032301	no	433	0.0610799408553278	224	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV	error-prone translesion synthesis|error-free translesion synthesis	DNA-directed DNA polymerase activity	replication fork
YDR163W	YDR163W	CWC15	hom	Verified	1.35660586788627	0.0874532381479444	no	434	0.0789507684152706	330	NA	FT	RNA PROCESSING	NUCLEUS		Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YGR182C_d	YGR182C	YGR182C	hom	Dubious	1.35555770320585	0.0876199686236965	no	435	0.0565198093657193	226	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W	Unknown	Unknown	Unknown
YGR049W	YGR049W	SCM4	hom	Verified	1.35530993517809	0.087659415465418	no	436	0.0948543420708927	308	NA	FT		MITOCHONDRION		Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to membrane
YLR364W	YLR364W	GRX8	hom	Verified	1.35387954914643	0.0878874045422699	no	437	0.0625188080208425	265	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic	biological_process	glutathione-disulfide reductase activity	cytoplasm
YJL083W	YJL083W	TAX4	hom	Verified	1.3512109500689	0.0883139339476752	no	438	0.0667055113865727	255	NA	FT	LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS			EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication	autophagy|fungal-type cell wall organization|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation	molecular_function	pre-autophagosomal structure
YPL149W	YPL149W	ATG5	hom	Verified	1.34991063686421	0.0885223246590071	no	439	0.0731741317748329	326	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation	C-terminal protein lipidation|mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy|CVT pathway	Atg8 ligase activity	cytosol|Atg12-Atg5-Atg16 complex|pre-autophagosomal structure|autophagic vacuole
YMR247W-A_p	YMR247W-A	YMR247W-A	hom	Uncharacterized	1.34663510037059	0.0890488918374309	no	440	0.0849719235370898	358	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR108W	YBR108W	AIM3	hom	Verified	1.34604959320529	0.0891432616313142	no	441	0.08039779216373	328	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss	actin cortical patch assembly	molecular_function	membrane raft|actin cortical patch
YGR089W	YGR089W	NNF2	hom	Verified	1.34522021664054	0.0892770647067985	no	442	0.0778144115136075	345	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation	biological_process	molecular_function	integral to membrane
YGL146C_p	YGL146C	RRT6	hom	Uncharacterized	1.34447613959093	0.0893972335481492	no	443	0.0672634427217023	264	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins	biological_process	molecular_function	membrane
YDR171W	YDR171W	HSP42	hom	Verified	1.34365607743934	0.0895298133535974	no	444	0.0684859261377092	243	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	cytoskeleton organization	unfolded protein binding	cytoskeleton|chaperonin-containing T-complex|cytoplasm
YPR074C	YPR074C	TKL1	hom	Verified	1.34360513216515	0.0895380545198321	no	445	0.129447820418936	510	NA	FF|FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication	pentose-phosphate shunt	transketolase activity	cytoplasm
YDR132C	YDR132C	YDR132C	hom	Verified	1.34351075950096	0.0895533222116087	no	446	0.0803532891212788	277	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YNL266W_d	YNL266W	YNL266W	hom	Dubious	1.34225264156275	0.0897570466059738	no	447	0.0714045896680202	297	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C	Unknown	Unknown	Unknown
YAL005C	YAL005C	SSA1	hom	Verified	1.34031819348582	0.0900709595311101	no	448	0.0631976920753286	249	NA	FT	PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION	NUCLEUS		ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils	cytoplasmic translation|protein folding|protein refolding|protein targeting to mitochondrion|SRP-dependent cotranslational protein targeting to membrane, translocation|protein import into nucleus, translocation|response to stress	unfolded protein binding|ATPase activity	fungal-type vacuole membrane|fungal-type cell wall|plasma membrane|nucleus|polysome|chaperonin-containing T-complex|cytoplasm
YLR319C	YLR319C	BUD6	hom	Verified	1.33801686840618	0.0904454690280066	no	449	0.101434439287935	309	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate	bipolar cellular bud site selection|positive regulation of formin-nucleated actin cable assembly|cellular bud site selection|Rho protein signal transduction|extrachromosomal circular DNA localization involved in cell aging|establishment of cell polarity|response to osmotic stress|cytokinesis	cytoskeletal regulatory protein binding	polarisome|actin cap|spindle pole body|mating projection tip
YCR089W	YCR089W	FIG2	hom	Verified	1.33670696399924	0.0906591539317296	no	450	0.0706417831141226	267	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating	filamentous growth of a population of unicellular organisms|cell morphogenesis involved in conjugation with cellular fusion|invasive growth in response to glucose limitation|cytogamy	molecular_function	fungal-type cell wall|mating projection
YLR034C	YLR034C	SMF3	hom	Verified	1.3357434608764	0.0908165693546949	no	451	0.0892305970777557	356	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress	cellular iron ion homeostasis|iron ion transport	metal ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YDL125C	YDL125C	HNT1	hom	Verified	1.33531634854729	0.0908864150498551	no	452	0.0922760992722851	351	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress	nucleotide metabolic process	hydrolase activity|nucleotide binding	nucleus|cytoplasm
YML055W	YML055W	SPC2	hom	Verified	1.33483195232655	0.0909656766035891	no	453	0.11003972790778	427	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25	signal peptide processing|protein targeting to ER	peptidase activity	signal peptidase complex
YKL163W	YKL163W	PIR3	hom	Verified	1.33407712243326	0.0910892913006399	no	454	0.0753512002178097	304	NA	FT	CELL WALL ORG/BIOGENESIS			O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall
YOL053W	YOL053W	AIM39	hom	Verified	1.33377372798491	0.0911390117705841	no	455	0.0662343653598523	233	NA	FT		MITOCHONDRION		Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YJR095W	YJR095W	SFC1	hom	Verified	1.33329385896094	0.0912176940910101	no	456	0.0831475675061735	311	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization	succinate transport|fumarate transport	succinate:fumarate antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YGR102C	YGR102C	GTF1	hom	Verified	1.33143669320949	0.0915226812819344	no	457	0.0933277460745528	390	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria	glutaminyl-tRNAGln biosynthesis via transamidation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YKL056C	YKL056C	TMA19	hom	Verified	1.33095942582965	0.0916011809358348	no	458	0.0937040347851546	396	NA	FT	TRANSLATION|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION|CYTOSKELETON		Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress	cytoplasmic translation|cellular response to oxidative stress	molecular_function	cytosol|mitochondrion|ribosome|cytoplasm
YPR064W_d	YPR064W	YPR064W	hom	Dubious	1.32921467070803	0.0918885781498105	no	459	0.0933690095254909	357	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL164C	YKL164C	PIR1	hom	Verified	1.32895940122672	0.0919306822476105	no	460	0.0843528648149008	306	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS			O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication	intracellular protein transport|fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall
YNR044W	YNR044W	AGA1	hom	Verified	1.32806718831682	0.0920779559088718	no	461	0.0551337782258562	228	NA					Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YJR031C	YJR031C	GEA1	hom	Verified	1.32773438017146	0.092132935794793	no	462	0.0797848635292205	294	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization	ARF guanyl-nucleotide exchange factor activity	integral to membrane|Golgi cis cisterna|Golgi-associated vesicle|extrinsic to membrane
YLL042C	YLL042C	ATG10	hom	Verified	1.32413027833786	0.0927298906435219	no	463	0.0703771190889955	267	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy	piecemeal microautophagy of nucleus|cellular protein modification process|mitochondrion degradation|macroautophagy|CVT pathway	Atg12 ligase activity	cellular_component
YGR080W	YGR080W	TWF1	hom	Verified	1.32322940340072	0.0928795503023707	no	464	0.0812488913005842	327	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly	bipolar cellular bud site selection|actin polymerization or depolymerization|sequestering of actin monomers	actin monomer binding	mating projection tip|actin cortical patch
YJL134W	YJL134W	LCB3	hom	Verified	1.3226739171869	0.0929719205304562	no	465	0.0916720523523766	324	NA	FT	LIPID METABOLISM|SIGNALING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication	calcium-mediated signaling|sphingolipid biosynthetic process	sphingosine-1-phosphate phosphatase activity	integral to membrane|endoplasmic reticulum
YML053C_p	YML053C	YML053C	hom	Uncharacterized	1.32072614932835	0.0932963458611294	no	466	0.0910073061529079	298	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YBL056W	YBL056W	PTC3	hom	Verified	1.31977382604689	0.0934552714405023	no	467	0.0846709230494077	367	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication	inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YPL008W	YPL008W	CHL1	hom	Verified	1.31800840226558	0.0937504176091592	no	468	0.0965769598010821	427	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS		Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome	negative regulation of DNA recombination|chromosome segregation|donor selection|DNA replication initiation|mitotic sister chromatid cohesion	DNA helicase activity	nucleus
YMR170C	YMR170C	ALD2	hom	Verified	1.31629383947319	0.0940377188872936	no	469	0.0864979843645	329	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p	cellular aldehyde metabolic process|beta-alanine biosynthetic process|polyamine catabolic process	aldehyde dehydrogenase (NAD) activity	cytoplasm
YDL033C	YDL033C	SLM3	hom	Verified	1.31241942289528	0.0946893284906817	no	470	0.113588507017601	417	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)	mitochondrial tRNA thio-modification	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	mitochondrion
YBL082C	YBL082C	ALG3	hom	Verified	1.31202370495848	0.0947560682209466	no	471	0.077559783391746	311	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins	oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation	alpha-1,3-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YFL034C-A	YFL034C-A	RPL22B	hom	Verified	1.30865883619463	0.095324970639675	no	472	0.102775876323148	407	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR058W	YGR058W	PEF1	hom	Verified	1.30684015581915	0.0956335020459076	no	473	0.0816126219084775	333	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH		Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly	bipolar cellular bud site selection|regulation of COPII vesicle coating|axial cellular bud site selection	zinc ion binding|calcium ion binding	cytosol|site of polarized growth|nucleus|cellular bud neck|cytoplasm
YJR149W_p	YJR149W	YJR149W	hom	Uncharacterized	1.30412315557842	0.0960957975032647	no	474	0.067199447802083	241	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YDR291W	YDR291W	HRQ1	hom	Verified	1.30374772711697	0.0961598053442283	no	475	0.0855896243418605	334	NA	FT		NUCLEUS		3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)	biological_process	molecular_function	nucleus
YBR081C	YBR081C	SPT7	hom	Verified	1.3034899125476	0.0962037790147773	no	476	0.143713701591617	524	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION	HISTONE ACETYLTRANSFERASE	Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex	conjugation with cellular fusion|histone acetylation|protein complex assembly|chromatin modification	structural molecule activity	SLIK (SAGA-like) complex|mitochondrion|SAGA complex
YML070W	YML070W	DAK1	hom	Verified	1.30195483121843	0.0964659134248936	no	477	0.0598555687995724	214	NA	FT	CARBOHYDRATE METABOLISM			Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation	response to stress|glycerol catabolic process	glycerone kinase activity	cytoplasm
YBL064C	YBL064C	PRX1	hom	Verified	1.29931478489199	0.0969179612398668	no	478	0.0589992775815019	241	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress	response to cadmium ion|cellular response to oxidative stress|cell redox homeostasis	thioredoxin peroxidase activity	mitochondrion
YBR033W_p	YBR033W	EDS1	hom	Uncharacterized	1.29624173544529	0.0974461074626422	no	479	0.0890311618441735	386	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication	biological_process	sequence-specific DNA binding	cellular_component
YOL132W	YOL132W	GAS4	hom	Verified	1.29517219769459	0.0976304167125748	no	480	0.0864053136715049	343	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall	ascospore wall assembly	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane
YMR039C	YMR039C	SUB1	hom	Verified	1.29385700545908	0.0978574089020474	no	481	0.0881988272512939	307	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress	termination of RNA polymerase II transcription|hyperosmotic response|RNA polymerase III transcriptional preinitiation complex assembly|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase III promoter	transcription coactivator activity	nucleus
YMR195W	YMR195W	ICY1	hom	Verified	1.29169770873007	0.0982309256368534	no	482	0.0859118625660321	320	NA					Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation	biological_process	molecular_function	fungal-type vacuole membrane
YGL186C	YGL186C	TPN1	hom	Verified	1.28827485433649	0.0988251515591729	no	483	0.226043132951345	787	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p	vitamin transport	vitamin transporter activity	integral to membrane|plasma membrane
YGL181W	YGL181W	GTS1	hom	Verified	1.28767060281646	0.0989303254556533	no	484	0.101451317319977	320	NA	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	NUCLEUS|CYTOSKELETON		Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations	endocytosis|ultradian rhythm|regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylinositol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	ARF GTPase activator activity|repressing transcription factor binding|transcription factor binding transcription factor activity	nucleus|cytoplasm|actin cortical patch
YPL192C	YPL192C	PRM3	hom	Verified	1.2864595161076	0.0991413694499046	no	485	0.0800491182020193	342	NA	FT	MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body	karyogamy involved in conjugation with cellular fusion|nuclear membrane fusion involved in karyogamy	molecular_function	nuclear envelope|spindle pole body|extrinsic to nuclear outer membrane
YLR120C	YLR120C	YPS1	hom	Verified	1.28491881100087	0.0994103283743931	no	486	0.118752985320084	395	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	PLASMA MEMBRANE		Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	fungal-type cell wall organization|protein processing	aspartic-type endopeptidase activity	fungal-type cell wall
YOR078W	YOR078W	BUD21	hom	Verified	1.28395213656559	0.0995793515793126	no	487	0.0966827696111824	371	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|90S preribosome
YMR133W	YMR133W	REC114	hom	Verified	1.2823903174271	0.0998528795453028	no	488	0.0652774214929149	219	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YOR175C	YOR175C	ALE1	hom	Verified	1.28094015287086	0.10010734394723	no	489	0.10387302070432	396	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids	glycerophospholipid biosynthetic process	1-acylglycerophosphocholine O-acyltransferase activity|O-acyltransferase activity|1-acylglycerol-3-phosphate O-acyltransferase activity	integral to membrane|ribosome|endoplasmic reticulum
YKL075C_p	YKL075C	YKL075C	hom	Uncharacterized	1.2808053918418	0.100131014860175	no	490	0.109391657998618	370	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin	response to drug	molecular_function	cytoplasm
YJR151W-A_p	YJR151W-A	YJR151W-A	hom	Uncharacterized	1.27977509786466	0.100312122109724	no	491	0.0922703338836096	325	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YNL249C	YNL249C	MPA43	hom	Verified	1.27904971450782	0.100439774862868	no	492	0.109356738195465	419	NA	FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YDR205W	YDR205W	MSC2	hom	Verified	1.27867023232391	0.10050660323376	no	493	0.108618798800433	422	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids	cellular zinc ion homeostasis|zinc ion transport|transmembrane transport	zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YEL072W	YEL072W	RMD6	hom	Verified	1.27857031502247	0.100524204474977	no	494	0.101299129108263	398	NA	FT	CELL CYCLE			Protein required for sporulation	biological_process	molecular_function	cellular_component
YPR097W	YPR097W	YPR097W	hom	Verified	1.27802383554686	0.100620511042896	no	495	0.115913518587799	472	NA	FT		MITOCHONDRION		Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	phosphatidylinositol binding	mitochondrion
YGL004C	YGL004C	RPN14	hom	Verified	1.27671861837985	0.100850802935671	no	496	0.112399744001635	349	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p	proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|cytoplasm
YBL066C	YBL066C	SEF1	hom	Verified	1.27566418856753	0.101037126486729	no	497	0.0785878206598438	336	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative transcription factor, has homolog in Kluyveromyces lactis	biological_process	molecular_function	cellular_component
YDR186C	YDR186C	YDR186C	hom	Verified	1.27507183981765	0.101141907779945	no	498	0.0927528319791964	384	NA					Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	ribosome|cytoplasm
YBR212W	YBR212W	NGR1	hom	Verified	1.27398804194255	0.101333827069122	no	499	0.115003011931418	399	NA	FT	MITOCHONDRION ORGANIZATION			RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase	3'-UTR-mediated mRNA destabilization|mitochondrion organization	mRNA binding	cytoplasmic mRNA processing body|cytoplasmic stress granule|perinuclear region of cytoplasm|cytoplasm
YBR180W	YBR180W	DTR1	hom	Verified	1.27370093855364	0.101384711854522	no	500	0.0969750308626763	340	NA	FT	CELL WALL ORG/BIOGENESIS			Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation	ascospore wall assembly|amine transport|transmembrane transport	amine transmembrane transporter activity	integral to membrane|prospore membrane
YDR246W-A_p	YDR246W-A	YDR246W-A	hom	Uncharacterized	1.26959413378802	0.102114620036537	no	501	0.0883484581751828	382	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YOR202W	YOR202W	HIS3	hom	Verified	1.26949324802307	0.102132598592496	no	502	0.0769841756451203	307	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p	histidine biosynthetic process	imidazoleglycerol-phosphate dehydratase activity	cellular_component
YPL060W	YPL060W	MFM1	hom	Verified	1.2694454703972	0.102141113706408	no	503	0.134552607587989	480	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p	mitochondrial magnesium ion transport	magnesium ion transmembrane transporter activity	integral to membrane|mitochondrial inner membrane
YDR272W	YDR272W	GLO2	hom	Verified	1.26752814019578	0.102483254096349	no	504	0.100432144470434	391	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM			Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate	cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate	hydroxyacylglutathione hydrolase activity	cytoplasm
YMR120C	YMR120C	ADE17	hom	Verified	1.26374617177855	0.10316057354348	no	505	0.0853680714141477	364	NA	FT	NUCLEOTIDE METABOLISM			Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity	cytosol|plasma membrane
YJL177W	YJL177W	RPL17B	hom	Verified	1.26301265605186	0.103292315712355	no	506	0.0958977988571641	384	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YNL239W	YNL239W	LAP3	hom	Verified	1.26296882652049	0.103300191525871	no	507	0.0928418719976836	375	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS	MITOCHONDRION		Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH	response to antibiotic|negative regulation of transcription from RNA polymerase II promoter|homocysteine catabolic process	double-stranded DNA binding|cysteine-type peptidase activity|mRNA binding|single-stranded DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	mitochondrion|cytoplasm
YLR443W	YLR443W	ECM7	hom	Verified	1.26245484564243	0.10339258228326	no	508	0.103385415607549	452	NA	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency	fungal-type cell wall organization|calcium ion transport	molecular_function	integral to membrane
YJR043C	YJR043C	POL32	hom	Verified	1.26206995782835	0.103461807152827	no	509	0.126943970655297	489	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p	RNA-dependent DNA replication|lagging strand elongation|postreplication repair|base-excision repair|DNA replication, removal of RNA primer|nucleotide-excision repair|mismatch repair|double-strand break repair via break-induced replication|leading strand elongation	DNA-directed DNA polymerase activity|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity	delta DNA polymerase complex|nucleus
YNR006W	YNR006W	VPS27	hom	Verified	1.26167610343076	0.103532679546631	no	510	0.147806993793547	553	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)	protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding|phosphatidylinositol-3-phosphate binding	endosome|ESCRT-0 complex
YMR018W_p	YMR018W	YMR018W	hom	Uncharacterized	1.26148469210131	0.103567135906343	no	511	0.120255743538435	421	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene	biological_process	molecular_function	cellular_component
YGL149W_d	YGL149W	YGL149W	hom	Dubious	1.26111738305191	0.103633279292734	no	512	0.0948471587267623	349	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.	Unknown	Unknown	Unknown
YNL135C	YNL135C	FPR1	hom	Verified	1.26054754762531	0.103735953384677	no	513	0.119872252713115	485	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION		Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function	protein folding|chromatin organization|homoserine metabolic process	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	mitochondrion|nucleus|cytoplasm
YPR130C_d	YPR130C	YPR130C	hom	Dubious	1.26029113547042	0.103782178308997	no	514	0.108345889758879	431	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR062C_p	YOR062C	YOR062C	hom	Uncharacterized	1.2600286749205	0.10382950908597	no	515	0.0864976009139398	300	NA	FT		NUCLEUS		Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YAL067W-A_p	YAL067W-A	YAL067W-A	hom	Uncharacterized	1.25934641305058	0.103952617906202	no	516	0.093887069102929	374	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YOR350C	YOR350C	MNE1	hom	Verified	1.25549152621959	0.104650191154136	no	517	0.106287503891213	390	NA	FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA	Group I intron splicing	molecular_function	mitochondrion|ribonucleoprotein complex|mitochondrial matrix
YKL047W_p	YKL047W	ANR2	hom	Uncharacterized	1.25368340638196	0.104978550807007	no	518	0.104976513876288	433	NA					Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YLR136C	YLR136C	TIS11	hom	Verified	1.25169761105639	0.105340035459515	no	519	0.0910195666569247	345	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS		mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	cellular iron ion homeostasis|nuclear-transcribed mRNA catabolic process	mRNA binding	nucleus|cytoplasm
YGR283C	YGR283C	YGR283C	hom	Verified	1.25094269048002	0.105477693544714	no	520	0.101029517427208	409	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus	biological_process	S-adenosylmethionine-dependent methyltransferase activity	ribosome|nucleolus
YOL062C	YOL062C	APM4	hom	Verified	1.24942692450843	0.105754482874967	no	521	0.0852607966727051	402	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport	intracellular protein transport|vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YPR174C	YPR174C	YPR174C	hom	Verified	1.24564509732081	0.106447359050169	no	522	0.0980734315701614	344	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication	biological_process	molecular_function	nuclear envelope|spindle pole body
YLR360W	YLR360W	VPS38	hom	Verified	1.24094760911845	0.107312551768136	no	523	0.0961834938931237	358	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated	ER-associated protein catabolic process|late endosome to vacuole transport	molecular_function	phosphatidylinositol 3-kinase complex II
YLR119W	YLR119W	SRN2	hom	Verified	1.24004851922873	0.107478724330275	no	524	0.115562532462662	455	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	protein binding	endosome|ESCRT I complex
YOR085W	YOR085W	OST3	hom	Verified	1.23967880779867	0.107547109316465	no	525	0.104824124078968	380	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins	protein glycosylation|protein complex assembly|protein O-linked mannosylation|protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex|integral to membrane
YIL079C	YIL079C	AIR1	hom	Verified	1.23954706568573	0.107571485039332	no	526	0.112324766119854	402	NA	FT	RNA PROCESSING	NUCLEUS		Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication	nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent snRNA catabolic process	polynucleotide adenylyltransferase activity	nucleolus|TRAMP complex
YKL184W	YKL184W	SPE1	hom	Verified	1.23913181145498	0.107648343940271	no	527	0.106199982141898	356	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation	pantothenate biosynthetic process|putrescine biosynthetic process	ornithine decarboxylase activity	cytoplasm
YGR217W	YGR217W	CCH1	hom	Verified	1.23797144446303	0.107863324592756	no	528	0.103638966465326	352	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together	calcium ion transport	voltage-gated calcium channel activity|calcium channel activity	integral to membrane|plasma membrane
YGL253W	YGL253W	HXK2	hom	Verified	1.23662545825129	0.108113081992145	no	529	0.111022196827936	430	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication	replicative cell aging|fructose import|regulation of transcription by glucose|glucose import|mannose metabolic process|glycolysis|glucose metabolic process|regulation of cell size|fructose metabolic process	hexokinase activity	cytosol|mitochondrion|nucleus
YOR043W	YOR043W	WHI2	hom	Verified	1.23504994629138	0.108405958094435	no	530	0.0882282344510791	347	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION			Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression	response to salt stress|mitochondrion degradation|actin filament organization|endocytosis|response to heat|regulation of growth|response to stress	phosphatase activator activity	cellular_component
YEL048C	YEL048C	TCA17	hom	Verified	1.23299377547459	0.108789043244172	no	531	0.0941296999306282	342	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS	GOLGI APPARATUS		Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder	early endosome to Golgi transport|protein complex assembly	molecular_function	TRAPP complex|Golgi apparatus|clathrin-coated vesicle
YLR036C_p	YLR036C	YLR036C	hom	Uncharacterized	1.23213688804056	0.108948976950716	no	532	0.0971995827234394	411	NA					Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein	biological_process	molecular_function	integral to membrane
YLR042C_p	YLR042C	YLR042C	hom	Uncharacterized	1.22869057791722	0.109593920087042	no	533	0.0909652332569016	313	NA					Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene	biological_process	molecular_function	fungal-type cell wall
YJR080C	YJR080C	AIM24	hom	Verified	1.2286816092513	0.109595602053545	no	534	0.0838110384634199	352	NA	FT		MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YML081C-A	YML081C-A	ATP18	hom	Verified	1.22822529895619	0.109681202078665	no	535	0.0943038461845223	339	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms	mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YNL162W-A_p	YNL162W-A	YNL162W-A	hom	Uncharacterized	1.22635925702639	0.110031755540137	no	536	0.100179830024262	391	NA	FT		NUCLEUS		Putative protein of unknown function; identified by homology	biological_process	molecular_function	nucleus|cytoplasm
YNR034W	YNR034W	SOL1	hom	Verified	1.22550273069365	0.110192930928891	no	537	0.0717291804697779	292	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	tRNA export from nucleus	molecular_function|6-phosphogluconolactonase activity	nucleus|cytoplasm
YPL189W	YPL189W	GUP2	hom	Verified	1.22388728470001	0.110497375471595	no	538	0.0668762832017693	260	NA					Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog	glycerol transport	O-acyltransferase activity	integral to membrane|membrane
YLR052W	YLR052W	IES3	hom	Verified	1.22316777153842	0.110633167768587	no	539	0.117672274173531	444	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the INO80 chromatin remodeling complex	nucleosome mobilization|telomere maintenance|chromatin silencing at telomere	molecular_function	nucleus|Ino80 complex
YFR032C_p	YFR032C	RRT5	hom	Uncharacterized	1.22311674469342	0.110642802504015	no	540	0.105981515946055	454	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation	biological_process	molecular_function	cellular_component
YDL138W	YDL138W	RGT2	hom	Verified	1.22311660650003	0.11064282859809	no	541	0.0814205768453941	283	NA	FT	SIGNALING	PLASMA MEMBRANE		Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication	glucose transport|signal transduction|detection of glucose	glucose transmembrane transporter activity|receptor activity|glucose binding	integral to membrane|plasma membrane
YFR038W	YFR038W	IRC5	hom	Verified	1.22309168070476	0.11064753523121	no	542	0.114136196688232	449	NA	FT		NUCLEUS		Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci	mitotic recombination	molecular_function	cellular_component
YNL259C	YNL259C	ATX1	hom	Verified	1.22248867913427	0.110761441210316	no	543	0.119177165005206	455	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS			Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake	copper ion transport|cellular response to oxidative stress|cellular iron ion homeostasis	copper chaperone activity	cytosol
YMR111C	YMR111C	YMR111C	hom	Verified	1.2224842196599	0.110762283910373	no	544	0.0842945862620074	284	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress	biological_process	molecular_function	nucleus
YNL042W	YNL042W	BOP3	hom	Verified	1.21851475424282	0.111514210725111	no	545	0.0886995115775191	299	NA	FT		NUCLEUS		Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury	cellular response to methylmercury	molecular_function	nucleus|cytoplasm
YPR159C-A_p	YPR159C-A	YPR159C-A	hom	Uncharacterized	1.21703207468405	0.111796006247209	no	546	0.0832496154632312	289	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YGR287C	YGR287C	IMA1	hom	Verified	1.21579485335587	0.112031539927517	no	547	0.110780759748734	423	NA	FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family	disaccharide catabolic process	oligo-1,6-glucosidase activity	mitochondrion|ribosome
YLL051C	YLL051C	FRE6	hom	Verified	1.21393021571839	0.112387186713376	no	548	0.0827923547659951	336	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels	intracellular sequestering of iron ion|copper ion import	ferric-chelate reductase activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YLR020C	YLR020C	YEH2	hom	Verified	1.21266789192501	0.112628410187644	no	549	0.101491489423873	383	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism	cell wall mannoprotein biosynthetic process|sterol metabolic process	sterol esterase activity	integral to membrane|plasma membrane
YGR007W	YGR007W	ECT1	hom	Verified	1.21266094187937	0.112629739327753	no	550	0.118757509535723	410	NA	FT	LIPID METABOLISM	NUCLEUS		Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases	phosphatidylethanolamine biosynthetic process	ethanolamine-phosphate cytidylyltransferase activity	nucleus|cytoplasm
YLL040C	YLL040C	VPS13	hom	Verified	1.21205720529229	0.112745241830782	no	551	0.111763063934082	426	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	MITOCHONDRION|GOLGI APPARATUS		Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively	protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole|ascospore-type prospore membrane assembly	molecular_function	endosome|mitochondrion|prospore membrane|extrinsic to membrane
YGR003W	YGR003W	CUL3	hom	Verified	1.21204845394523	0.112746916696635	no	552	0.0950194902683037	350	NA	FT	PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3	protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	nucleus|Cul3-RING ubiquitin ligase complex|cytoplasm
YIR018C-A_p	YIR018C-A	YIR018C-A	hom	Uncharacterized	1.21160212264607	0.112832360826075	no	553	0.103658778226112	424	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YDR446W	YDR446W	ECM11	hom	Verified	1.21108188781672	0.112932011125337	no	554	0.0740382301544576	301	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	NUCLEUS		Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure	fungal-type cell wall organization|reciprocal meiotic recombination	molecular_function	nucleus
YJR131W	YJR131W	MNS1	hom	Verified	1.21081547782422	0.112983065925013	no	555	0.115614985288379	361	NA	FT	CARBOHYDRATE METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation	ER-associated protein catabolic process|protein deglycosylation involved in glycoprotein catabolic process	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum
YDL182W	YDL182W	LYS20	hom	Verified	1.21008442739585	0.113123249018121	no	556	0.0867250041176848	318	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication	lysine biosynthetic process via aminoadipic acid	homocitrate synthase activity	mitochondrion|nucleus
YPL114W_d	YPL114W	YPL114W	hom	Dubious	1.20997515325561	0.11314421361586	no	557	0.107116828025053	416	NA					Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index	Unknown	Unknown	Unknown
YGL081W_p	YGL081W	YGL081W	hom	Uncharacterized	1.20866905501284	0.113395007407714	no	558	0.0799726518698206	283	NA					Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis	biological_process	molecular_function	cellular_component
YJL030W	YJL030W	MAD2	hom	Verified	1.20843247592954	0.113440477124252	no	559	0.104546121086738	423	NA	FT	CELL CYCLE|CELL DIVISION	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME	NUCLEAR PORE|KINETOCHORE	Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I	chromosome decondensation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	mitotic checkpoint complex|condensed nuclear chromosome kinetochore|nuclear pore
YBR207W	YBR207W	FTH1	hom	Verified	1.20798126713251	0.11352723400611	no	560	0.0677089887589663	277	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS			Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress	endocytosis|high-affinity iron ion transport	iron ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YKL201C	YKL201C	MNN4	hom	Verified	1.20738004682314	0.11364290809147	no	561	0.109059570060934	370	NA	FT	CARBOHYDRATE METABOLISM			Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication	protein O-linked glycosylation|protein N-linked glycosylation|response to stress	molecular_function	membrane
YFL010C	YFL010C	WWM1	hom	Verified	1.20708543214661	0.113699622275918	no	562	0.110136774879609	387	NA	FT		NUCLEUS|MITOCHONDRION		WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1	biological_process	molecular_function	mitochondrion|nucleus|cytoplasm
YGL117W_p	YGL117W	YGL117W	hom	Uncharacterized	1.20665737332693	0.113782060795161	no	563	0.170211193688718	623	NA	FF				Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL281W	YNL281W	HCH1	hom	Verified	1.20653922990908	0.11380482116886	no	564	0.0808203292096036	318	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress	protein folding|response to stress	ATPase activator activity|chaperone binding	nucleus|cytoplasm
YOR081C	YOR081C	TGL5	hom	Verified	1.20579359122603	0.113948543605495	no	565	0.0945751495610501	345	NA	FT	LIPID METABOLISM			Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate	triglyceride mobilization	lysophosphatidic acid acyltransferase activity|triglyceride lipase activity	lipid particle
YDR295C	YDR295C	HDA2	hom	Verified	1.20486967910229	0.114126807725448	no	566	0.0949005860998672	330	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance	negative regulation of transcription from RNA polymerase II promoter|gene silencing by RNA|histone deacetylation|gene silencing involved in chronological cell aging	histone deacetylase activity|chromatin binding|DNA binding	nucleus|HDA1 complex
YDL053C	YDL053C	PBP4	hom	Verified	1.20286745610541	0.114513807890119	no	567	0.121509562036375	451	NA	FT		NUCLEUS		Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasmic stress granule|cytoplasm
YJR021C	YJR021C	REC107	hom	Verified	1.20133237016747	0.114811149314028	no	568	0.110049338961844	430	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation	reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YIR013C	YIR013C	GAT4	hom	Verified	1.2005353872679	0.114965738874918	no	569	0.0842388651786035	315	NA	FT		NUCLEUS		Protein containing GATA family zinc finger motifs	transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YKR095W	YKR095W	MLP1	hom	Verified	1.19765303645524	0.115526059771079	no	570	0.105417123042356	355	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs	protein localization to nuclear pore|poly(A)+ mRNA export from nucleus|protein import into nucleus|transcriptional activation by promoter-terminator looping|nuclear retention of unspliced pre-mRNA at the site of transcription|telomere tethering at nuclear periphery	ribonucleoprotein complex binding	nucleoplasm|nuclear envelope|integral to membrane|ribonucleoprotein complex|spindle pole body
YDR057W	YDR057W	YOS9	hom	Verified	1.19750881455795	0.115554146986273	no	571	0.10913711438694	358	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family	ER-associated protein catabolic process	oligosaccharide binding	luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum lumen
YKR065C	YKR065C	PAM17	hom	Verified	1.19738077401287	0.115579086948398	no	572	0.0915644150317579	366	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress	protein import into mitochondrial matrix	molecular_function	mitochondrion|presequence translocase-associated import motor
YBR090C_p	YBR090C	YBR090C	hom	Uncharacterized	1.1940138345638	0.116236278205861	no	573	0.0953367086280825	353	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YDR193W_d	YDR193W	YDR193W	hom	Dubious	1.19382817407328	0.116272594171567	no	574	0.0858687894140104	325	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAL020C	YAL020C	ATS1	hom	Verified	1.18947541020069	0.117126320852539	no	575	0.125125116156004	499	NA	FT	RNA PROCESSING|CELL DIVISION|CYTOSKELETON ORGANIZATION			Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle	microtubule-based process|budding cell bud growth|microtubule cytoskeleton organization|tRNA wobble uridine modification	molecular_function	cytoplasm
YOR038C	YOR038C	HIR2	hom	Verified	1.18905626150354	0.117208764137212	no	576	0.10881568294351	398	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p	DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter	nucleosome binding|transcription corepressor activity|DNA binding	HIR complex|nucleus
YER056C	YER056C	FCY2	hom	Verified	1.18781234571289	0.117453674683085	no	577	0.0890988122898983	344	NA	FT		PLASMA MEMBRANE		Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress	cytosine transport|cytidine transport|purine nucleobase transport|transmembrane transport	nucleobase transmembrane transporter activity|cytidine transmembrane transporter activity	integral to membrane|plasma membrane
YKL136W_d	YKL136W	YKL136W	hom	Dubious	1.18763506289208	0.117488608802436	no	578	0.143021415580958	460	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C	Unknown	Unknown	Unknown
YML120C	YML120C	NDI1	hom	Verified	1.18718222521759	0.117577875237771	no	579	0.0901032552967505	347	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID	mitochondrial electron transport, NADH to ubiquinone|NADH oxidation|chronological cell aging|positive regulation of apoptotic process	NADH dehydrogenase (ubiquinone) activity	mitochondrion|mitochondrial matrix
YOL121C	YOL121C	RPS19A	hom	Verified	1.18579638838417	0.117851359071118	no	580	0.119214231101675	439	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit biogenesis|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YJL068C	YJL068C	YJL068C	hom	Verified	1.18536162021342	0.11793724977737	no	581	0.0997171761304083	368	NA					Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D	formaldehyde catabolic process	S-formylglutathione hydrolase activity	cytosol
YGL255W	YGL255W	ZRT1	hom	Verified	1.18388233530283	0.118229821829952	no	582	0.0873052433368351	313	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor	high-affinity zinc ion transport	high affinity zinc uptake transmembrane transporter activity	integral to membrane|integral to plasma membrane
YOR222W	YOR222W	ODC2	hom	Verified	1.18318340267527	0.11836823466844	no	583	0.0984168644691679	392	NA	FT		MITOCHONDRION		Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism	mitochondrial transport	dicarboxylic acid transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YIL135C	YIL135C	VHS2	hom	Verified	1.18292907096638	0.118418629559076	no	584	0.0869845491067789	347	NA	FT	CELL CYCLE			Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p	G1/S transition of mitotic cell cycle	molecular_function	cytoplasm
YER063W	YER063W	THO1	hom	Verified	1.1823643544769	0.118530580266843	no	585	0.0855624768885057	333	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation	poly(A)+ mRNA export from nucleus|transcription, DNA-dependent|ribonucleoprotein complex assembly	chromatin binding|double-stranded DNA binding|RNA binding	nucleus
YPL198W	YPL198W	RPL7B	hom	Verified	1.18003447564478	0.11899325166039	no	586	0.12598282804861	460	NA	FT	TRANSLATION	NUCLEUS	RIBOSOME	Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit|nucleolus|cytoplasm
YMR084W_p	YMR084W	YMR084W	hom	Uncharacterized	1.17715616290301	0.119566590959035	no	587	0.124411076607927	476	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1	biological_process	molecular_function	cellular_component
YMR017W	YMR017W	SPO20	hom	Verified	1.17495198676451	0.120006962611735	no	588	0.0938144091493086	381	NA	FT		PLASMA MEMBRANE		Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog	ascospore-type prospore assembly	SNAP receptor activity	SNARE complex|prospore membrane
YLL028W	YLL028W	TPO1	hom	Verified	1.17312265847667	0.120373310656941	no	589	0.0784175554351403	306	NA	FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane	spermidine transport|putrescine transport|spermine transport	spermidine transmembrane transporter activity|spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|cellular bud membrane|plasma membrane
YKR041W	YKR041W	YKR041W	hom	Verified	1.17240053220666	0.120518142969489	no	590	0.0991938062138383	365	NA	FT		NUCLEUS|CYTOSKELETON		Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking	biological_process	molecular_function	nucleus|mitotic spindle|cytoplasm
YLR098C	YLR098C	CHA4	hom	Verified	1.17223351856646	0.120551657307585	no	591	0.125529910741259	422	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain	positive regulation of transcription, DNA-dependent|cellular amino acid catabolic process	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YGR181W	YGR181W	TIM13	hom	Verified	1.17005381811413	0.120989655828542	no	592	0.0866555476150144	355	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane	protein import into mitochondrial inner membrane	protein transporter activity	mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex|mitochondrial intermembrane space
YGR097W	YGR097W	ASK10	hom	Verified	1.1697887913728	0.121042987708202	no	593	0.121137468115166	403	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS	RNA POL II, HOLOENZYME	Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication	cellular protein catabolic process|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glycerol transport	molecular_function	DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YGR139W_d	YGR139W	YGR139W	hom	Dubious	1.1691920756404	0.121163126584375	no	594	0.0915973322295047	364	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR064C_d	YCR064C	YCR064C	hom	Dubious	1.1675693519626	0.121490259336957	no	595	0.157812787468759	593	NA	FF				Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31	Unknown	Unknown	Unknown
YOR022C_p	YOR022C	YOR022C	hom	Uncharacterized	1.16390768158146	0.122230713130786	no	596	0.112253941180008	425	NA	FT	LIPID METABOLISM	MITOCHONDRION		Putative carboxylic ester hydrolase; similar to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	phospholipase activity	mitochondrion
YDL142C	YDL142C	CRD1	hom	Verified	1.16352270689906	0.122308745405108	no	597	0.115345690529457	386	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis	lipid biosynthetic process|cellular ion homeostasis|mitochondrial membrane organization	cardiolipin synthase activity	mitochondrion|integral to membrane
YOR111W_p	YOR111W	YOR111W	hom	Uncharacterized	1.16204110197962	0.12260938488468	no	598	0.106349863134154	399	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YFR018C_p	YFR018C	YFR018C	hom	Uncharacterized	1.16171565907171	0.122675491434459	no	599	0.112891668944743	396	NA	FT	PROTEOLYSIS			Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR176W	YMR176W	ECM5	hom	Verified	1.16092137294743	0.122836938106252	no	600	0.11942230338398	447	NA	FT	CELL WALL ORG/BIOGENESIS	NUCLEUS|CHROMOSOME		Non-essential protein of unknown function; contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress	fungal-type cell wall organization	molecular_function	nucleus|Snt2C complex
YER027C	YER027C	GAL83	hom	Verified	1.15926056699621	0.123174995016069	no	601	0.123982150674768	394	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS		One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain	signal transduction|cell adhesion|protein phosphorylation|invasive growth in response to glucose limitation|regulation of protein complex assembly	AMP-activated protein kinase activity	AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|cytoplasm
YER046W	YER046W	SPO73	hom	Verified	1.15923656639254	0.123179885111554	no	602	0.11189817978804	375	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis	ascospore wall assembly|ascospore formation	molecular_function	cytosol
YNL065W	YNL065W	AQR1	hom	Verified	1.15913514707253	0.123200550683971	no	603	0.105708475889196	388	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress	monocarboxylic acid transport|drug transmembrane transport|amino acid export	monocarboxylic acid transmembrane transporter activity|drug transmembrane transporter activity	integral to membrane|plasma membrane
YDR428C	YDR428C	BNA7	hom	Verified	1.15844455022748	0.123341333829774	no	604	0.100671793910279	398	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine	NAD biosynthetic process	arylformamidase activity	cellular_component
YEL049W	YEL049W	PAU2	hom	Verified	1.15735370897895	0.123563939241886	no	605	0.0953765774410087	326	NA					Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YDL218W_p	YDL218W	YDL218W	hom	Uncharacterized	1.15682229124725	0.12367248627364	no	606	0.082892908110701	325	NA					Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin	biological_process	molecular_function	integral to membrane|cytoplasm
YDR051C	YDR051C	DET1	hom	Verified	1.1564698025035	0.123744522210588	no	607	0.108784570778903	362	NA	FT		NUCLEUS		Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel	intracellular sterol transport|dephosphorylation	acid phosphatase activity	nucleus|cytoplasm
YPL222W_p	YPL222W	FMP40	hom	Uncharacterized	1.1510793733243	0.124849791465342	no	608	0.125329918947378	453	NA	FT		MITOCHONDRION		Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGR199W	YGR199W	PMT6	hom	Verified	1.15098104480046	0.124870016887833	no	609	0.114519171298014	408	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases	protein O-linked glycosylation|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane
YIR005W	YIR005W	IST3	hom	Verified	1.15074819348375	0.12491792174521	no	610	0.111075364672442	441	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing	mRNA export from nucleus|spliceosomal complex assembly|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step	first spliceosomal transesterification activity	RES complex|U2 snRNP
YMR029C	YMR029C	FAR8	hom	Verified	1.14588585684755	0.125921191978039	no	611	0.106200595071031	377	NA	FT	CELL CYCLE|SIGNALING	ENDOPLASMIC RETICULUM		Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	cellular_component
YHL020C	YHL020C	OPI1	hom	Verified	1.14499718198047	0.126105162360481	no	612	0.142158577352088	543	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|SIGNALING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance	endoplasmic reticulum unfolded protein response|negative regulation of transcription from RNA polymerase II promoter|phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	transcription corepressor activity	nuclear membrane|nucleoplasm|nuclear envelope|endoplasmic reticulum|nucleus
YLR085C	YLR085C	ARP6	hom	Verified	1.14490968180417	0.126123286470453	no	613	0.17221770645261	656	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A	chromatin remodeling|histone exchange	nucleosome binding	Swr1 complex|cytoplasm
YDR319C_p	YDR319C	YFT2	hom	Uncharacterized	1.14437108994699	0.12623488621108	no	614	0.124011011205995	476	NA					Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens	biological_process	molecular_function	integral to membrane
YDL149W	YDL149W	ATG9	hom	Verified	1.14373951694383	0.126365839900021	no	615	0.101747373373657	316	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|MITOCHONDRION		Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS	piecemeal microautophagy of nucleus|mitochondrion degradation|protein homooligomerization|CVT pathway|autophagic vacuole assembly	molecular_function	mitochondrion|integral to membrane|pre-autophagosomal structure
YJR004C	YJR004C	SAG1	hom	Verified	1.14155901993429	0.126818683117746	no	616	0.126202787236891	427	NA					Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YNL184C_p	YNL184C	YNL184C	hom	Uncharacterized	1.14150884146512	0.126829117409259	no	617	0.150972702035371	525	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YKR029C	YKR029C	SET3	hom	Verified	1.14061952884434	0.127014143448447	no	618	0.132060133852245	483	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication	negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation	methylated histone residue binding	Rpd3L-Expanded complex|Set3 complex
YDR268W	YDR268W	MSW1	hom	Verified	1.14001193264455	0.127140664916888	no	619	0.147379374653107	515	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial tryptophanyl-tRNA synthetase	mitochondrial tryptophanyl-tRNA aminoacylation	tryptophan-tRNA ligase activity	mitochondrion
YNR024W	YNR024W	MPP6	hom	Verified	1.13895208097125	0.127361570659234	no	620	0.125330820989493	461	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes	nuclear mRNA surveillance of spliceosomal pre-mRNA splicing|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	poly(U) RNA binding	ribosome|nucleus|nuclear exosome (RNase complex)|TRAMP complex
YNL183C	YNL183C	NPR1	hom	Verified	1.13849530253118	0.127456859633195	no	621	0.115934058178124	445	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	GOLGI APPARATUS|PLASMA MEMBRANE		Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex	regulation of transmembrane transporter activity|regulation of nitrogen utilization|protein phosphorylation|negative regulation of endocytosis	protein serine/threonine kinase activity	Golgi apparatus|plasma membrane|cytoplasm
YDR266C	YDR266C	HEL2	hom	Verified	1.13846204710104	0.127463799014953	no	622	0.132912588183915	427	NA					RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor	biological_process	molecular_function	ribosome|cytoplasm
YHR006W	YHR006W	STP2	hom	Verified	1.13828842783869	0.127500032262247	no	623	0.106990004769964	417	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|PLASMA MEMBRANE		Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YBL071W-A	YBL071W-A	KTI11	hom	Verified	1.13754117487245	0.12765606099846	no	624	0.173849437158658	626	NA	FT	RNA PROCESSING	NUCLEUS		Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs	peptidyl-diphthamide biosynthetic process from peptidyl-histidine|tRNA wobble uridine modification	electron carrier activity|iron ion binding|zinc ion binding	nucleus|cytoplasm
YCL026C-A	YCL026C-A	FRM2	hom	Verified	1.13720591288812	0.127726107858551	no	625	0.105713478508513	417	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin	cellular response to oxidative stress|negative regulation of fatty acid metabolic process	oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor	nucleus|cytoplasm
YJR074W	YJR074W	MOG1	hom	Verified	1.13684739860908	0.127801042414827	no	626	0.132238568069476	527	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p	protein import into nucleus	Ran GTPase binding	nucleus
YDR093W	YDR093W	DNF2	hom	Verified	1.13535924964804	0.128112413197937	no	627	0.114803617551419	423	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase	intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity	phospholipid-translocating ATPase activity	integral to membrane|plasma membrane
YOR339C	YOR339C	UBC11	hom	Verified	1.13168050064975	0.128884391158403	no	628	0.119198289391863	410	NA					Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2	protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YBR301W	YBR301W	PAU24	hom	Verified	1.12915326312149	0.129416592817742	no	629	0.116059511612664	423	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth	biological_process	molecular_function	fungal-type cell wall
YDR440W	YDR440W	DOT1	hom	Verified	1.1280957616992	0.129639739448057	no	630	0.131910339247555	458	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS		Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response	meiotic recombination checkpoint|postreplication repair|recombinational repair|global genome nucleotide-excision repair|nucleotide-excision repair|DNA damage checkpoint|chromatin silencing at telomere|histone H3-K79 methylation	nucleosomal histone binding|histone methyltransferase activity (H3-K79 specific)	nucleus
YMR102C_p	YMR102C	YMR102C	hom	Uncharacterized	1.12790809551118	0.129679367295154	no	631	0.116810634386065	432	NA					Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene	biological_process	molecular_function	cellular_component
YBL036C	YBL036C	YBL036C	hom	Verified	1.12627922507986	0.130023674227174	no	632	0.0966108592622453	297	NA					Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS	biological_process	pyridoxal phosphate binding	cellular_component
YGR055W	YGR055W	MUP1	hom	Verified	1.12355841659044	0.130600202698968	no	633	0.133695187056737	450	NA	FT		PLASMA MEMBRANE		High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake	cysteine transport|sulfur amino acid transport|methionine transport	L-methionine secondary active transmembrane transporter activity	integral to membrane|integral to plasma membrane
YOR242C	YOR242C	SSP2	hom	Verified	1.12251074844657	0.130822670038028	no	634	0.109730183938016	418	NA	FT	CELL WALL ORG/BIOGENESIS			Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis	ascospore wall assembly|ascospore formation	molecular_function	ascospore wall
YDR100W	YDR100W	TVP15	hom	Verified	1.12184140900041	0.130964938125926	no	635	0.129882931334016	383	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p	vesicle-mediated transport	molecular_function	COPI-coated vesicle|integral to membrane|integral to Golgi membrane
YOR271C_p	YOR271C	FSF1	hom	Uncharacterized	1.12142141355087	0.131054262717729	no	636	0.120831025098529	436	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis	biological_process	molecular_function	mitochondrion|integral to membrane
YJR142W_p	YJR142W	YJR142W	hom	Uncharacterized	1.12095580713248	0.131153337030307	no	637	0.122402381729057	495	NA					Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member	biological_process	molecular_function	cellular_component
YBL015W	YBL015W	ACH1	hom	Verified	1.12086403877911	0.131172870110391	no	638	0.116455118417245	349	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth	acetate metabolic process	acetate CoA-transferase activity|acetyl-CoA hydrolase activity	cytosol|mitochondrion
YEL057C_p	YEL057C	YEL057C	hom	Uncharacterized	1.11986014908264	0.131386681292062	no	639	0.103374617325717	379	NA					Protein of unknown function involved in telomere maintenance; target of UME6 regulation	biological_process	molecular_function	cellular_component
YKL183W	YKL183W	LOT5	hom	Verified	1.11947511109736	0.131468751547978	no	640	0.113621810061506	422	NA	FT		NUCLEUS		Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YGL114W_p	YGL114W	YGL114W	hom	Uncharacterized	1.11923356266359	0.13152025528706	no	641	0.0993424564762802	319	NA	FT	PROTEIN LOCALIZATION			Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters	transport	oligopeptide transporter activity	integral to membrane|membrane
YKR046C	YKR046C	PET10	hom	Verified	1.11809291999543	0.131763654971289	no	642	0.122923841591453	441	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange	aerobic respiration	molecular_function	lipid particle
YNL291C	YNL291C	MID1	hom	Verified	1.11655952543568	0.132091352747764	no	643	0.105186586154819	362	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer	calcium ion transport	stretch-activated, cation-selective, calcium channel activity|calcium channel activity	endoplasmic reticulum|plasma membrane
YNL092W_p	YNL092W	YNL092W	hom	Uncharacterized	1.11524092782127	0.1323735958782	no	644	0.113042905451003	378	NA					Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YLR250W	YLR250W	SSP120	hom	Verified	1.11412801059056	0.132612136765044	no	645	0.130897490044006	448	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YAR002C-A	YAR002C-A	ERP1	hom	Verified	1.11350650952128	0.132745477085127	no	646	0.109094029315503	427	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport	molecular_function	mitochondrion|ER to Golgi transport vesicle
YBR189W	YBR189W	RPS9B	hom	Verified	1.11041860358164	0.133409342637677	no	647	0.135356516337947	461	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication	positive regulation of translational fidelity|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YKL215C	YKL215C	OXP1	hom	Verified	1.11037453166471	0.133418834112166	no	648	0.10824439112922	356	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	glutathione metabolic process	5-oxoprolinase (ATP-hydrolyzing) activity	cytoplasm
YJL110C	YJL110C	GZF3	hom	Verified	1.10783007904482	0.133967603553552	no	649	0.14386642081794	485	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication	maintenance of protein location in nucleus|nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YOR289W_p	YOR289W	YOR289W	hom	Uncharacterized	1.1077338035431	0.133988397978993	no	650	0.116877605369949	402	NA	FT		NUCLEUS		Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YEL067C_p	YEL067C	YEL067C	hom	Uncharacterized	1.10540974494414	0.13449104154564	no	651	0.139196688128883	475	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YHR049W	YHR049W	FSH1	hom	Verified	1.10486617514325	0.13460879047507	no	652	0.104505605299058	410	NA	FT		NUCLEUS		Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2	biological_process	hydrolase activity	nucleus|cytoplasm
YGL085W_p	YGL085W	LCL3	hom	Uncharacterized	1.1042999340719	0.1347315257152	no	653	0.120644926328144	474	NA	FT		MITOCHONDRION		Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	mitochondrion
YML083C	YML083C	YML083C	hom	Verified	1.10427690741321	0.134736518469028	no	654	0.108562922517263	376	NA					Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions	biological_process	molecular_function	cellular_component
YEL051W	YEL051W	VMA8	hom	Verified	1.10205797844992	0.135218233259171	no	655	0.159274834881729	520	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YKR070W_p	YKR070W	YKR070W	hom	Uncharacterized	1.10113070296137	0.135419888020528	no	656	0.13316274874431	470	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YJL078C	YJL078C	PRY3	hom	Verified	1.10112730955249	0.135420626364046	no	657	0.102223794634994	382	NA					Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p	biological_process	molecular_function	fungal-type cell wall
YGR022C_d	YGR022C	YGR022C	hom	Dubious	1.09888632818855	0.135908825392436	no	658	0.102301513543035	356	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W	Unknown	Unknown	Unknown
YMR147W_p	YMR147W	YMR147W	hom	Uncharacterized	1.09885660306079	0.135915309115929	no	659	0.108755273874021	383	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YEL025C_p	YEL025C	YEL025C	hom	Uncharacterized	1.09648875277896	0.136432471352533	no	660	0.0983752047193528	348	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YGR221C	YGR221C	TOS2	hom	Verified	1.0946023229328	0.136845448738172	no	661	0.126146856330032	478	NA	FT	CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p	budding cell bud growth	molecular_function	cellular bud neck|cellular bud tip
YDR330W	YDR330W	UBX5	hom	Verified	1.09354212184929	0.137077922724653	no	662	0.106768514425973	360	NA	FT	PROTEOLYSIS	NUCLEUS		UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p	proteasomal ubiquitin-dependent protein catabolic process	molecular_function	nucleus|cytoplasm
YJL137C	YJL137C	GLG2	hom	Verified	1.09278473512877	0.137244162689034	no	663	0.126370574060573	453	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication	glycogen biosynthetic process	glycogenin glucosyltransferase activity	cytoplasm
YBR115C	YBR115C	LYS2	hom	Verified	1.09198352962701	0.137420170327821	no	664	0.120815112230059	435	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p	lysine biosynthetic process via aminoadipic acid	L-aminoadipate-semialdehyde dehydrogenase activity	cytoplasm
YOR304W	YOR304W	ISW2	hom	Verified	1.09175215038058	0.137471028046342	no	665	0.129864590755166	409	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth	negative regulation of transcription from RNA polymerase II promoter by pheromones|nucleosome positioning|termination of RNA polymerase II transcription|negative regulation of antisense RNA transcription|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere	single-stranded DNA binding|DNA translocase activity	chromatin accessibility complex|nucleus
YGR039W_d	YGR039W	YGR039W	hom	Dubious	1.09074365909138	0.137692846927903	no	666	0.136225290152269	520	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722	Unknown	Unknown	Unknown
YGL230C_p	YGL230C	YGL230C	hom	Uncharacterized	1.08794187719585	0.138310383677105	no	667	0.115484903461741	409	NA					Putative protein of unknown function; non-essential gene	biological_process	molecular_function	cellular_component
YKL079W	YKL079W	SMY1	hom	Verified	1.0877897293184	0.13834397233307	no	668	0.116535169394199	425	NA	FT	VESICLE-MEDIATED TRANSPORT	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins	exocytosis	motor activity	incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YJR109C	YJR109C	CPA2	hom	Verified	1.08647054904586	0.138635431911079	no	669	0.114247822155812	424	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor	arginine biosynthetic process	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carbamoyl-phosphate synthase complex
YLR174W	YLR174W	IDP2	hom	Verified	1.08628699085045	0.138676020371883	no	670	0.112808475762066	412	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication	glutamate biosynthetic process|isocitrate metabolic process	isocitrate dehydrogenase (NADP+) activity	cytosol
YLR300W	YLR300W	EXG1	hom	Verified	1.08596477774164	0.138747287836357	no	671	0.120590389344005	436	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes	fungal-type cell wall organization|cellular glucan metabolic process	glucan exo-1,3-beta-glucosidase activity	extracellular region|fungal-type cell wall
YDR282C_p	YDR282C	YDR282C	hom	Uncharacterized	1.08445595466866	0.139081342925933	no	672	0.110238217177176	415	NA					Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation	biological_process	molecular_function	cellular_component
YBL094C_d	YBL094C	YBL094C	hom	Dubious	1.08332498156728	0.139332100315298	no	673	0.120307546931183	398	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W	Unknown	Unknown	Unknown
YNL022C_p	YNL022C	YNL022C	hom	Uncharacterized	1.08230986255709	0.139557432530551	no	674	0.124842456854801	474	NA	FT		NUCLEUS		Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis	biological_process	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YDL024C	YDL024C	DIA3	hom	Verified	1.08228821840159	0.139562239713872	no	675	0.167977312577404	583	NA					Protein of unknown function, involved in invasive and pseudohyphal growth	pseudohyphal growth|invasive growth in response to glucose limitation	acid phosphatase activity	fungal-type cell wall
YBR177C	YBR177C	EHT1	hom	Verified	1.08166029782969	0.139701750372264	no	676	0.131159340746413	471	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication	medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process|cellular lipid metabolic process	short-chain carboxylesterase activity|alcohol O-butanoyltransferase activity|serine hydrolase activity	mitochondrial outer membrane|mitochondrion|lipid particle
YHR146W	YHR146W	CRP1	hom	Verified	1.0801291824291	0.140042329175398	no	677	0.159098795783576	582	NA	FT		NUCLEUS		Protein that binds to cruciform DNA structures	biological_process	DNA binding	nucleus
YLR142W	YLR142W	PUT1	hom	Verified	1.07962314033848	0.140155016287135	no	678	0.123876393263352	452	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source	glutamate biosynthetic process|proline catabolic process to glutamate	proline dehydrogenase activity	mitochondrion
YGR161C_p	YGR161C	RTS3	hom	Uncharacterized	1.07927338798698	0.140232936276827	no	679	0.137827087368415	492	NA	FT		NUCLEUS		Putative component of the protein phosphatase type 2A complex	biological_process	molecular_function	nucleus|cytoplasm
YLR456W_p	YLR456W	YLR456W	hom	Uncharacterized	1.0791871782565	0.140252147132496	no	680	0.112097965326112	476	NA	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	NUCLEUS		Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDL155W	YDL155W	CLB3	hom	Verified	1.07830820220747	0.14044811894435	no	681	0.138005883373402	467	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress	G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|cytoplasm
YAL002W	YAL002W	VPS8	hom	Verified	1.07777937037891	0.140566114002441	no	682	0.145325327778639	547	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif	late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole	GTPase binding|protein anchor	late endosome|membrane|CORVET complex
YGR137W_d	YGR137W	YGR137W	hom	Dubious	1.07775968735612	0.140570507055156	no	683	0.132668446294853	470	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL141C	YJL141C	YAK1	hom	Verified	1.07708943912555	0.14072015533837	no	684	0.12558183657562	480	NA	FT	PROTEIN PHOSPHORYLATION	NUCLEUS		Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose	protein phosphorylation	protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity	nucleus|cytoplasm
YMR178W	YMR178W	YMR178W	hom	Verified	1.07476947254145	0.14123897557917	no	685	0.120482295018916	446	NA	FT	COFACTOR METABOLISM	NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YBR161W	YBR161W	CSH1	hom	Verified	1.07475820310198	0.141241498954453	no	686	0.116755530089399	472	NA	FT	LIPID METABOLISM			Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication	glycosphingolipid biosynthetic process|sphingolipid biosynthetic process	mannosyltransferase activity|transferase activity, transferring glycosyl groups	integral to membrane|fungal-type vacuole
YLR126C	YLR126C	YLR126C	hom	Verified	1.07424726653809	0.141355936457184	no	687	0.129467331026825	474	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS			Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	cellular copper ion homeostasis|cellular iron ion homeostasis	molecular_function	cytoplasm
YGL108C	YGL108C	YGL108C	hom	Verified	1.07365930817713	0.141487702739931	no	688	0.134643061764017	505	NA					Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cellular_component
YML054C-A_p	YML054C-A	YML054C-A	hom	Uncharacterized	1.07324582505968	0.141580417524361	no	689	0.117726337882385	396	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR024W_d	YOR024W	YOR024W	hom	Dubious	1.07321560810789	0.141587194645939	no	690	0.140348705221389	431	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL168W	YIL168W	YIL168W	hom	pseudogene	1.07016915567879	0.142271587635075	no	691	0.142535190225272	480	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase	serine family amino acid metabolic process	L-serine ammonia-lyase activity	cellular_component
YGR062C	YGR062C	COX18	hom	Verified	1.07015993794056	0.142273661813394	no	692	0.142626099610978	526	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC	protein insertion into mitochondrial membrane from inner side	membrane insertase activity	integral to membrane|integral to mitochondrial inner membrane
YBR148W	YBR148W	YSW1	hom	Verified	1.07012847903504	0.142280740860159	no	693	0.115365307305685	400	NA	FT	MEMBRANE ORGANIZATION			Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane	ascospore-type prospore membrane assembly	molecular_function	prospore membrane
YLR393W	YLR393W	ATP10	hom	Verified	1.0698996909253	0.14233223112133	no	694	0.138847034065579	466	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6	mitochondrial proton-transporting ATP synthase complex assembly	unfolded protein binding	integral to mitochondrial membrane|mitochondrion|mitochondrial inner membrane
YJL139C	YJL139C	YUR1	hom	Verified	1.06899220923457	0.142536589976431	no	695	0.14705070493018	533	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication	cell wall mannoprotein biosynthetic process|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YNR009W	YNR009W	NRM1	hom	Verified	1.06859693082713	0.14262566606185	no	696	0.130156411002466	466	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase	negative regulation of transcription involved in G1 phase of mitotic cell cycle	repressing transcription factor binding|transcription factor binding transcription factor activity	MBF transcription complex|nucleus|cytoplasm
YJR069C	YJR069C	HAM1	hom	Verified	1.06838723022839	0.142672937420989	no	697	0.12442043494585	459	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine; protein abundance increases in response to DNA replication stress	purine deoxyribonucleoside triphosphate catabolic process|pyrimidine deoxyribonucleoside triphosphate catabolic process	dITP diphosphatase activity|ITP diphosphatase activity|XTP diphosphatase activity|dCTP diphosphatase activity|UTP diphosphatase activity|dTTP diphosphatase activity|dATP pyrophosphohydrolase activity|dGTP diphosphatase activity|dUTP diphosphatase activity|GTP diphosphatase activity	nucleus|cytoplasm
YPR047W	YPR047W	MSF1	hom	Verified	1.06681503506488	0.143027683941276	no	698	0.170313946756202	620	NA	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase	phenylalanyl-tRNA aminoacylation|mitochondrial phenylalanyl-tRNA aminoacylation	phenylalanine-tRNA ligase activity	mitochondrion
YLL023C	YLL023C	POM33	hom	Verified	1.06643627236052	0.143113236099202	no	699	0.133031240834795	443	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	NUCLEAR PORE	Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress	nuclear pore organization|nuclear pore complex assembly	structural constituent of nuclear pore	ribosome|integral to membrane|endoplasmic reticulum|nuclear pore
YHL026C_p	YHL026C	YHL026C	hom	Uncharacterized	1.06619916706413	0.143166809305387	no	700	0.151894330849334	512	NA					Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)	biological_process	molecular_function	cellular_component
YDR207C	YDR207C	UME6	hom	Verified	1.06286841438875	0.143920814319994	no	701	0.226466118897774	778	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|CHROMOSOME		Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p	spore germination|positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter during meiosis|lipid particle organization|nitrogen catabolite repression of transcription from RNA polymerase II promoter|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|repressing transcription factor binding|transcription factor binding transcription factor activity	Rpd3L-Expanded complex|Rpd3L complex
YOR013W_d	YOR013W	IRC11	hom	Dubious	1.06233554535924	0.144041691580553	no	702	0.117393716720232	467	NA					Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci	Unknown	Unknown	Unknown
YIL146C	YIL146C	ATG32	hom	Verified	1.0613480451539	0.144265879399419	no	703	0.122767485275808	437	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane	fungal-type cell wall organization|mitochondrion degradation	molecular_function	integral to mitochondrial outer membrane
YHL017W_p	YHL017W	YHL017W	hom	Uncharacterized	1.06104117170726	0.144335595403522	no	704	0.121775062137893	431	NA	FT		GOLGI APPARATUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane|clathrin-coated vesicle
YAL061W_p	YAL061W	BDH2	hom	Uncharacterized	1.06098788244654	0.144347704057199	no	705	0.107571441533228	385	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3	biological_process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	nucleus|cytoplasm
YER031C	YER031C	YPT31	hom	Verified	1.06094784878419	0.144356801157548	no	706	0.202326089192318	696	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication	early endosome to Golgi transport|vesicle-mediated transport|exocytosis	GTPase activity	mitochondrial outer membrane|endosome|Golgi apparatus
YJL112W	YJL112W	MDV1	hom	Verified	1.06079788202992	0.144390882479127	no	707	0.165682915567404	578	NA	FT	MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	MITOCHONDRION		Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication	peroxisome fission|mitochondrial fission|mitochondrial genome maintenance	ubiquitin binding	mitochondrial outer membrane|mitochondrion
YGR123C	YGR123C	PPT1	hom	Verified	1.0599779006581	0.144577326651968	no	708	0.142471476076695	439	NA	FT		NUCLEUS		Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth	protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YPR199C	YPR199C	ARR1	hom	Verified	1.05965127724297	0.144651638162353	no	709	0.131051040215578	483	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds	positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YOR092W	YOR092W	ECM3	hom	Verified	1.05933943157763	0.144722611527461	no	710	0.1366003552713	420	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication	fungal-type cell wall organization	ATPase activity	integral to membrane|endoplasmic reticulum
YML109W	YML109W	ZDS2	hom	Verified	1.05895014930515	0.144811241699398	no	711	0.106673920648794	349	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|GENE SILENCING	NUCLEUS|SITE OF POLARIZED GROWTH		Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication	positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|establishment of cell polarity|regulation of protein localization|chromatin silencing at rDNA|cell aging	molecular_function	nucleus|cellular bud neck|cellular bud tip|cytoplasm
YKL066W_d	YKL066W	YKL066W	hom	Dubious	1.0583786876037	0.144941415926269	no	712	0.0969464922058952	346	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene YNK1	Unknown	Unknown	Unknown
YOR325W_d	YOR325W	YOR325W	hom	Dubious	1.05707395197047	0.145238919045806	no	713	0.147679861721034	565	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1	Unknown	Unknown	Unknown
YER085C_p	YER085C	YER085C	hom	Uncharacterized	1.05644144331551	0.145383290129824	no	714	0.12119220026188	448	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR026C	YDR026C	NSI1	hom	Verified	1.05589276409183	0.145508605180459	no	715	0.118912489062643	383	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication	termination of RNA polymerase I transcription|chromatin silencing at rDNA|Unknown	DNA binding	ribosome|nucleolus|rDNA heterochromatin
YGL157W	YGL157W	ARI1	hom	Verified	1.05585368073114	0.145517534356791	no	716	0.129845571935775	467	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily	biological_process	oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YBR217W	YBR217W	ATG12	hom	Verified	1.05502273775229	0.14570746286681	no	717	0.155351252470038	559	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly	Atg8 ligase activity|protein tag	Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YDR345C	YDR345C	HXT3	hom	Verified	1.05459385113173	0.145805558592523	no	718	0.170695959084727	603	NA	FT		PLASMA MEMBRANE		Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication	hexose transport|transmembrane transport	mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YER064C	YER064C	VHR2	hom	Verified	1.05442593656958	0.145843976404294	no	719	0.122223550123313	444	NA	FT		NUCLEUS		Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	regulation of transcription, DNA-dependent	molecular_function	nucleus
YER149C	YER149C	PEA2	hom	Verified	1.05399755848139	0.145942017472339	no	720	0.132082155395488	486	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth	bipolar cellular bud site selection|regulation of initiation of mating projection growth|regulation of termination of mating projection growth|actin filament organization|pseudohyphal growth|establishment of cell polarity|filamentous growth|Rho protein signal transduction	cytoskeletal regulatory protein binding	polarisome|actin cap|mating projection tip
YKL162C_p	YKL162C	YKL162C	hom	Uncharacterized	1.05374592668442	0.145999628012398	no	721	0.113835252367972	387	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion
YDR516C	YDR516C	EMI2	hom	Verified	1.0525297107011	0.146278293336211	no	722	0.142936602516154	499	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YBR058C	YBR058C	UBP14	hom	Verified	1.04800366301859	0.147318459611434	no	723	0.145557406230266	521	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T	protein deubiquitination|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	cytoplasm
YER045C	YER045C	ACA1	hom	Verified	1.04562154428695	0.147867899167589	no	724	0.135957762820465	472	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YMR142C	YMR142C	RPL13B	hom	Verified	1.04521313840838	0.147962236239428	no	725	0.162106141829485	577	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR178W	YDR178W	SDH4	hom	Verified	1.04512110377031	0.147983500745863	no	726	0.175946089172809	574	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain	mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion
YOR163W	YOR163W	DDP1	hom	Verified	1.04325967035725	0.14841402205435	no	727	0.129857117516165	464	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress	polyphosphate catabolic process|inositol phosphate dephosphorylation|diadenosine polyphosphate catabolic process	diphosphoinositol-polyphosphate diphosphatase activity|endopolyphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|bis(5'-adenosyl)-hexaphosphatase activity	nucleus|cytoplasm
YEL004W	YEL004W	YEA4	hom	Verified	1.04269123898045	0.148545658400213	no	728	0.110953282045686	358	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER	fungal-type cell wall chitin biosynthetic process|UDP-N-acetylglucosamine transport|UDP-glucose transport|transmembrane transport	UDP-N-acetylglucosamine transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YLL033W	YLL033W	IRC19	hom	Verified	1.04166402755825	0.148783736177011	no	729	0.128672053188556	462	NA					Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci	mitotic recombination|ascospore formation	molecular_function	cellular_component
YOR099W	YOR099W	KTR1	hom	Verified	1.04116640110178	0.148899163183474	no	730	0.131000923012307	487	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress	N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YJL126W	YJL126W	NIT2	hom	Verified	1.03972781273612	0.149233187566339	no	731	0.150121780752806	555	NA					Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member	biological_process	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	cellular_component
YCL048W	YCL048W	SPS22	hom	Verified	1.03873680038277	0.149463580573239	no	732	0.143660250223941	529	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall	ascospore wall assembly|fungal-type cell wall organization	molecular_function	plasma membrane
YLR023C	YLR023C	IZH3	hom	Verified	1.0384814170582	0.149522991174133	no	733	0.102202769763666	349	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity	cellular zinc ion homeostasis	metal ion binding	integral to membrane|endoplasmic reticulum|membrane
YKL031W_d	YKL031W	YKL031W	hom	Dubious	1.03734455981457	0.149787652955939	no	734	0.155597730682028	515	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species	Unknown	Unknown	Unknown
YER120W	YER120W	SCS2	hom	Verified	1.03635258052116	0.150018842110098	no	735	0.145584864043191	562	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication	endoplasmic reticulum inheritance|regulation of intracellular lipid transport|negative regulation of transcription factor import into nucleus|phospholipid biosynthetic process|chromatin silencing at telomere	phosphatidylinositol binding|FFAT motif binding	nuclear membrane|integral to endoplasmic reticulum membrane|nuclear envelope|endoplasmic reticulum|cellular bud tip
YOR247W	YOR247W	SRL1	hom	Verified	1.03527847792943	0.15026943893153	no	736	0.155996973214233	530	NA	FT	CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH		Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication	fungal-type cell wall organization|nucleobase-containing compound metabolic process	molecular_function	fungal-type cell wall|fungal-type vacuole|cytoplasm|cellular bud tip
YHL015W-A_p	YHL015W-A	YHL015W-A	hom	Uncharacterized	1.0345226208949	0.150445953629129	no	737	0.136952954068536	476	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YIL088C	YIL088C	AVT7	hom	Verified	1.03243628244184	0.150933891196923	no	738	0.126300823424267	458	NA	FT		PLASMA MEMBRANE		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane|fungal-type vacuole
YER060W-A	YER060W-A	FCY22	hom	Verified	1.03184338800468	0.151072744987929	no	739	0.125925302190692	385	NA					Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function	transmembrane transport	nucleobase transmembrane transporter activity	integral to membrane
YIL018W	YIL018W	RPL2B	hom	Verified	1.0300635540184	0.151490086273711	no	740	0.136648315681266	474	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YNR030W	YNR030W	ALG12	hom	Verified	1.02712928108225	0.152179796241134	no	741	0.180916768162431	593	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation	dolichol-linked oligosaccharide biosynthetic process|protein glycosylation	alpha-1,6-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YLR413W_p	YLR413W	YLR413W	hom	Uncharacterized	1.0252144854625	0.152630997404169	no	742	0.143079885466896	535	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; YLR413W is not an essential gene	biological_process	molecular_function	integral to membrane
YLR013W	YLR013W	GAT3	hom	Verified	1.02446264633109	0.152808402679254	no	743	0.145865293908005	496	NA	FT		NUCLEUS		Protein containing GATA family zinc finger motifs	transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YLR251W	YLR251W	SYM1	hom	Verified	1.0214352576286	0.15352413405134	no	744	0.140490747017402	473	NA	FT		MITOCHONDRION		Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17	ethanol metabolic process	molecular_function	mitochondrion|integral to membrane|mitochondrial inner membrane
YOR005C	YOR005C	DNL4	hom	Verified	1.01949501879757	0.153984008390942	no	745	0.135175165397683	464	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	NUCLEUS|CHROMOSOME		DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth	double-strand break repair via nonhomologous end joining|replicative cell aging	DNA ligase (ATP) activity	DNA ligase IV complex|nuclear chromatin
YKL135C	YKL135C	APL2	hom	Verified	1.01871668817845	0.154168743783679	no	746	0.195580984477654	626	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE		Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YOL084W	YOL084W	PHM7	hom	Verified	1.01754521589961	0.154447066905055	no	747	0.107579460641297	389	NA	FT		PLASMA MEMBRANE		Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YOR374W	YOR374W	ALD4	hom	Verified	1.01665928890651	0.154657769475156	no	748	0.140183629099102	497	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed	NADPH regeneration|ethanol metabolic process|pyruvate metabolic process|acetate biosynthetic process	aldehyde dehydrogenase [NAD(P)+] activity|aldehyde dehydrogenase (NAD) activity	mitochondrial nucleoid|mitochondrion
YLL057C	YLL057C	JLP1	hom	Verified	1.01552297097145	0.154928301182486	no	749	0.123623023984144	423	NA	FT	OXIDATION-REDUCTION PROCESS			Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation	sulfur compound catabolic process	sulfonate dioxygenase activity	cellular_component
YHR134W	YHR134W	WSS1	hom	Verified	1.01547301150683	0.15494020257428	no	750	0.111832658527318	471	NA	FT	RESPONSE TO DNA DAMAGE	ENDOMEMBRANE SYSTEM|NUCLEUS		Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response	protein sumoylation|response to UV-B|response to UV-C|response to DNA damage stimulus	molecular_function	nuclear envelope
YKL070W_p	YKL070W	YKL070W	hom	Uncharacterized	1.01273875124816	0.155592481527274	no	751	0.130135008985455	464	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YJL146W	YJL146W	IDS2	hom	Verified	1.01249841839767	0.155649901265012	no	752	0.142062868905184	481	NA	FT	CELL CYCLE	NUCLEUS		Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation	meiosis	molecular_function	nucleus|cytoplasm
YCR030C	YCR030C	SYP1	hom	Verified	1.01218523647001	0.155724746896032	no	753	0.140883283150646	444	NA	FT	CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization	septin cytoskeleton organization|actin cortical patch assembly	molecular_function	mating projection base|mating projection tip|cellular bud neck|cellular bud tip
YER030W	YER030W	CHZ1	hom	Verified	1.01177721097444	0.155822294268352	no	754	0.117398926859584	400	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress	chromatin remodeling	histone binding	chromatin assembly complex|nucleus
YGR130C	YGR130C	YGR130C	hom	Verified	1.01124762160761	0.155948964196162	no	755	0.179708318479504	620	NA					Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)	biological_process	molecular_function	eisosome|membrane raft|cytoplasm
YER024W	YER024W	YAT2	hom	Verified	1.01122510954613	0.155954350251156	no	756	0.150268798661317	487	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM			Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane	carnitine metabolic process|alcohol metabolic process	carnitine O-acetyltransferase activity	cytosol|cytoplasm
YDR443C	YDR443C	SSN2	hom	Verified	1.01099797878442	0.156008698591893	no	757	0.176141914076737	607	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II transcription coactivator activity|RNA polymerase II transcription factor recruiting transcription factor activity	mediator complex
YNL214W	YNL214W	PEX17	hom	Verified	1.01099656957666	0.156009035829139	no	758	0.172943587322847	593	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis	protein import into peroxisome matrix, docking	protein binding	peroxisomal membrane
YJL150W_d	YJL150W	YJL150W	hom	Dubious	1.01018660499877	0.156202947801416	no	759	0.133622600372404	486	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER019C-A	YER019C-A	SBH2	hom	Verified	1.00989573169451	0.156272623923501	no	760	0.152875442464998	519	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p	SRP-dependent cotranslational protein targeting to membrane	ARF guanyl-nucleotide exchange factor activity	Ssh1 translocon complex
YJL148W	YJL148W	RPA34	hom	Verified	1.00963615254096	0.15633482109456	no	761	0.103369694405658	393	NA	FT		NUCLEUS		RNA polymerase I subunit A34.5	transcription elongation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	molecular_function	DNA-directed RNA polymerase I complex|nucleolus|nucleus
YOR208W	YOR208W	PTP2	hom	Verified	1.00639834701965	0.157111994234579	no	762	0.144943575221834	493	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus	inactivation of MAPK activity involved in osmosensory signaling pathway|inactivation of MAPK activity involved in cell wall biogenesis|regulation of sporulation|regulation of protein localization|protein dephosphorylation	protein tyrosine phosphatase activity	nucleus
YLL045C	YLL045C	RPL8B	hom	Verified	1.00621554368385	0.157155948318415	no	763	0.144817120148313	516	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR178C	YLR178C	TFS1	hom	Verified	1.00498570760022	0.157451866005802	no	764	0.12052233793777	424	NA	FT	SIGNALING|PROTEOLYSIS			Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress	regulation of Ras protein signal transduction|regulation of proteolysis	lipid binding|peptidase inhibitor activity|phospholipid binding	fungal-type vacuole lumen|fungal-type vacuole membrane|cytoplasm
YNR072W	YNR072W	HXT17	hom	Verified	1.00450192399517	0.157568372161351	no	765	0.14865858422177	563	NA	FT		PLASMA MEMBRANE		Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose	hexose transport	mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YPR073C	YPR073C	LTP1	hom	Verified	1.00395146535059	0.157701004067683	no	766	0.141329590494237	525	NA	FT		NUCLEUS		Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine	protein dephosphorylation	protein tyrosine phosphatase activity	nucleus|cytoplasm
YPL047W	YPL047W	SGF11	hom	Verified	1.00313971981082	0.15789672630649	no	767	0.15337747801081	570	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation	histone deubiquitination|regulation of transcription from RNA polymerase II promoter	enzyme activator activity	DUBm complex|nucleus|SAGA complex
YBR263W	YBR263W	SHM1	hom	Verified	1.00310566525507	0.157904940780473	no	768	0.119299338823834	421	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine	serine family amino acid biosynthetic process|one-carbon metabolic process	glycine hydroxymethyltransferase activity	mitochondrion
YKL123W_d	YKL123W	YKL123W	hom	Dubious	1.00281256326819	0.157975653014612	no	769	0.169646674010253	557	NA					Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4	Unknown	Unknown	Unknown
YLR055C	YLR055C	SPT8	hom	Verified	1.00250507488886	0.158049858376397	no	770	0.165824004061913	595	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters	histone acetylation|negative regulation of transcription from RNA polymerase II promoter|chromatin modification|positive regulation of transcription from RNA polymerase II promoter	TBP-class protein binding|transcription cofactor activity	nucleus|SAGA complex
YKL053W_d	YKL053W	YKL053W	hom	Dubious	1.00173777229533	0.158235129267877	no	771	0.143556172040503	530	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1	Unknown	Unknown	Unknown
YHR111W	YHR111W	UBA4	hom	Verified	1.0014142387619	0.158313291532865	no	772	0.168436029628755	609	NA	FT	RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS			Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p	cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|tRNA thio-modification|Unknown|invasive growth in response to glucose limitation	URM1 activating enzyme activity|sulfurtransferase activity|thiosulfate sulfurtransferase activity|protein adenylyltransferase activity	cytoplasm
YMR110C	YMR110C	HFD1	hom	Verified	0.999696875183584	0.158728612379603	no	773	0.133153924751676	486	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder	cellular aldehyde metabolic process	3-chloroallyl aldehyde dehydrogenase activity	mitochondrial outer membrane|endosome|mitochondrion|lipid particle|integral to mitochondrial outer membrane
YHR202W_p	YHR202W	YHR202W	hom	Uncharacterized	0.997565857790241	0.159244961928942	no	774	0.159888881067228	606	NA	FT	NUCLEOTIDE METABOLISM			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization	biological_process	molecular_function	cytosol|fungal-type vacuole
YNR028W	YNR028W	CPR8	hom	Verified	0.997034065008609	0.15937398764909	no	775	0.139786742111979	465	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	fungal-type vacuole
YDL123W	YDL123W	SNA4	hom	Verified	0.996891563957108	0.159408573456888	no	776	0.175229279895108	527	NA					Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated	biological_process	molecular_function	fungal-type vacuole lumen|fungal-type vacuole membrane
YGR015C_p	YGR015C	YGR015C	hom	Uncharacterized	0.99612526809473	0.159594642032807	no	777	0.174092473891501	589	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion
YHR041C	YHR041C	SRB2	hom	Verified	0.995840321957218	0.15966386763541	no	778	0.207937432938012	687	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding	core mediator complex
YOR375C	YOR375C	GDH1	hom	Verified	0.995526058443621	0.159740238464752	no	779	0.151397816449885	514	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication	glutamate biosynthetic process|ammonia assimilation cycle	glutamate dehydrogenase (NADP+) activity	nucleus|cytoplasm
YIL107C	YIL107C	PFK26	hom	Verified	0.994247058761012	0.160051301440884	no	780	0.170671922892152	601	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YDR260C	YDR260C	SWM1	hom	Verified	0.993536487550817	0.16022428909114	no	781	0.164362698932215	568	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation	ascospore wall assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of mitotic metaphase/anaphase transition|protein ubiquitination	molecular_function	anaphase-promoting complex|nucleus
YDL236W	YDL236W	PHO13	hom	Verified	0.992803294184659	0.160402912140978	no	782	0.171067824352497	567	NA	FT		NUCLEUS		Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity	protein dephosphorylation	4-nitrophenylphosphatase activity|phosphoprotein phosphatase activity|alkaline phosphatase activity	nucleus|cytoplasm
YAL044W-A_p	YAL044W-A	YAL044W-A	hom	Uncharacterized	0.992121674413806	0.160569087324906	no	783	0.124662454515546	428	NA					Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein	biological_process	molecular_function	cellular_component
YOR188W	YOR188W	MSB1	hom	Verified	0.991061996518744	0.160827654247928	no	784	0.19981413144201	742	NA	FT		MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress	establishment of cell polarity	molecular_function	mitochondrion|cellular bud neck|cellular bud tip
YPR196W_p	YPR196W	YPR196W	hom	Uncharacterized	0.990138405452012	0.16105323687122	no	785	0.15133981045739	563	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative maltose-responsive transcription factor	regulation of transcription, DNA-dependent	sequence-specific DNA binding	cellular_component
YML074C	YML074C	FPR3	hom	Verified	0.989363127991329	0.16124275395176	no	786	0.140279646865711	457	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS		Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p	meiotic recombination checkpoint	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	nucleolus
YOL140W	YOL140W	ARG8	hom	Verified	0.98843068300311	0.161470883366642	no	787	0.141783518589993	486	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine	arginine biosynthetic process|ornithine biosynthetic process	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	mitochondrion|mitochondrial matrix
YGR028W	YGR028W	MSP1	hom	Verified	0.985981973028006	0.162070979531718	no	788	0.143116788688326	463	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase	protein targeting to mitochondrion	ATPase activity	mitochondrial outer membrane|mitochondrion
YLR046C_p	YLR046C	YLR046C	hom	Uncharacterized	0.984928602460331	0.162329571335106	no	789	0.149438022381329	508	NA					Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	biological_process	molecular_function	integral to membrane
YDR317W	YDR317W	HIM1	hom	Verified	0.984541050560074	0.162424778947746	no	790	0.140814512834313	498	NA	FT	RESPONSE TO DNA DAMAGE			Protein of unknown function involved in DNA repair	DNA repair	molecular_function	cellular_component
YBR187W_p	YBR187W	GDT1	hom	Uncharacterized	0.98375387364537	0.162618271954668	no	791	0.167191962509647	615	NA					Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YCL044C	YCL044C	MGR1	hom	Verified	0.982429823190286	0.162944069941492	no	792	0.151511277281034	493	NA	FT	PROTEOLYSIS	MITOCHONDRION		Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA	misfolded or incompletely synthesized protein catabolic process	misfolded protein binding	mitochondrion|i-AAA complex
YNL045W	YNL045W	LAP2	hom	Verified	0.981874965749269	0.163080725149146	no	793	0.147469830134226	504	NA	FT	KETONE METABOLISM|LIPID METABOLISM|PROTEOLYSIS	NUCLEUS		Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	cellular lipid metabolic process|protein catabolic process	aminopeptidase activity|leukotriene-A4 hydrolase activity|epoxide hydrolase activity	nucleus|cytoplasm
YJR040W	YJR040W	GEF1	hom	Verified	0.979723663719216	0.163611270979276	no	794	0.169702612470265	661	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE		Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism	cellular copper ion homeostasis|cellular iron ion homeostasis	voltage-gated chloride channel activity	endosome|integral to membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|fungal-type vacuole|Golgi medial cisterna
YPR126C_d	YPR126C	YPR126C	hom	Dubious	0.97969125818439	0.163619271265736	no	795	0.165494424292394	545	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR201C	YOR201C	MRM1	hom	Verified	0.979472538562293	0.163673275462645	no	796	0.171597276818703	623	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	MITOCHONDRION		Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA	rRNA modification	rRNA (guanine-N1-)-methyltransferase activity	mitochondrion
YPR003C_p	YPR003C	YPR003C	hom	Uncharacterized	0.97906186429568	0.163774706557774	no	797	0.172154412744368	598	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YOR302W	YOR302W	YOR302W	hom	Verified	0.978026106502452	0.16403070616351	no	798	0.143267186713025	464	NA	FT	TRANSLATION			CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA	regulation of translation	translation regulator activity	cytosol
YDL110C	YDL110C	TMA17	hom	Verified	0.977801857159221	0.164086166170209	no	799	0.143319606177307	501	NA	FT		NUCLEUS		Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YOR300W_d	YOR300W	YOR300W	hom	Dubious	0.977578267557084	0.164141475122194	no	800	0.141677894241014	469	NA					Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7	Unknown	Unknown	Unknown
YLR246W	YLR246W	ERF2	hom	Verified	0.977510579021895	0.164158221495827	no	801	0.138099506615155	476	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole	protein targeting to membrane|protein palmitoylation	palmitoyltransferase activity	endoplasmic reticulum palmitoyltransferase complex|integral to endoplasmic reticulum membrane|integral to membrane
YKL077W_p	YKL077W	YKL077W	hom	Uncharacterized	0.976149358221302	0.164495227347104	no	802	0.178192458581026	625	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	fungal-type vacuole
YLR016C	YLR016C	PML1	hom	Verified	0.97560569681956	0.16462995018584	no	803	0.119536831119958	431	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p	mRNA export from nucleus|mRNA splicing, via spliceosome|maintenance of RNA location	molecular_function	RES complex|nucleus|cytoplasm
YKL130C	YKL130C	SHE2	hom	Verified	0.974732062206581	0.164846592250216	no	804	0.131767988459879	473	NA	FT	RNA LOCALIZATION	NUCLEUS|SITE OF POLARIZED GROWTH		RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud	mating type switching|intracellular mRNA localization	mRNA binding	cellular bud tip|cytoplasm
YLR375W	YLR375W	STP3	hom	Verified	0.974562381542011	0.164888690707252	no	805	0.181217172428176	608	NA	FT		NUCLEUS		Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids	biological_process	sequence-specific DNA binding	nucleus
YDR259C	YDR259C	YAP6	hom	Verified	0.973643578309919	0.165116770411018	no	806	0.139671076846081	506	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding transcription factor recruiting transcription factor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YBR287W_p	YBR287W	YBR287W	hom	Uncharacterized	0.973400685969562	0.165177099059925	no	807	0.137576590387456	451	NA	FT		ENDOPLASMIC RETICULUM		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YJL161W_p	YJL161W	FMP33	hom	Uncharacterized	0.972872839861746	0.165308252595639	no	808	0.140760894753235	493	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YCR088W	YCR088W	ABP1	hom	Verified	0.971672177485478	0.165606831194716	no	809	0.150921047967316	517	NA	FT	PROTEIN LOCALIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences	protein localization|actin cortical patch assembly	actin filament binding	cell cortex|mating projection tip|cytoplasm|actin cortical patch
YAL012W	YAL012W	CYS3	hom	Verified	0.970950633970266	0.165786431028549	no	810	0.208350131043881	722	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress	sulfur amino acid metabolic process|cysteine biosynthetic process|cysteine biosynthetic process via cystathionine|transsulfuration|cysteine metabolic process	cystathionine gamma-lyase activity	cytoplasm
YGR226C_d	YGR226C	YGR226C	hom	Dubious	0.970944016577521	0.165788078750272	no	811	0.170686618803546	565	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W	Unknown	Unknown	Unknown
YML084W_d	YML084W	YML084W	hom	Dubious	0.969622642903226	0.166117311099237	no	812	0.138245851503953	495	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCL074W	YCL074W	YCL074W	hom	pseudogene	0.968336447250644	0.166438183910123	no	813	0.161201444482834	551	NA	FT		NUCLEUS		Pseudogene: encodes fragment of Ty Pol protein	transposition, RNA-mediated	ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity	retrotransposon nucleocapsid
YIL117C	YIL117C	PRM5	hom	Verified	0.968168350232201	0.166480149349869	no	814	0.150562243284312	517	NA					Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling	biological_process	molecular_function	integral to membrane
YMR041C	YMR041C	ARA2	hom	Verified	0.967757363815483	0.166582780919812	no	815	0.15841502860891	485	NA	FT	OXIDATION-REDUCTION PROCESS			NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase	dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinose 1-dehydrogenase [NAD(P)+] activity	cellular_component
YNL327W	YNL327W	EGT2	hom	Verified	0.965895149907456	0.167048324766018	no	816	0.168724325859923	553	NA	FT	CELL CYCLE|CELL DIVISION			Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner	cytokinesis	cellulase activity	fungal-type cell wall|cellular bud|cell septum
YIR004W	YIR004W	DJP1	hom	Verified	0.965885728121264	0.167050682294895	no	817	0.146364597153124	489	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ	protein import into peroxisome matrix	chaperone binding	cytosol
YDR116C	YDR116C	MRPL1	hom	Verified	0.964957782551233	0.167282978884715	no	818	0.158757676375241	554	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YKL001C	YKL001C	MET14	hom	Verified	0.964748597290369	0.167335373870864	no	819	0.150284837157216	498	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process	adenylylsulfate kinase activity	cytoplasm
YLL032C	YLL032C	YLL032C	hom	Verified	0.963790854959954	0.167575396255277	no	820	0.146246956920182	470	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene	biological_process	molecular_function	ribosome|cytoplasm
YNL283C	YNL283C	WSC2	hom	Verified	0.963589187833184	0.167625964848125	no	821	0.200712881204122	701	NA	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response	fungal-type cell wall organization|response to heat|Rho protein signal transduction	transmembrane signaling receptor activity	site of polarized growth|cellular bud|mating projection tip|cytoplasm
YGL151W	YGL151W	NUT1	hom	Verified	0.961312433880225	0.168197548972635	no	822	0.162278161481705	572	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription	regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	molecular_function	mitochondrion|mediator complex|nucleus
YGR152C	YGR152C	RSR1	hom	Verified	0.961197774849564	0.168226367501751	no	823	0.166184098897762	528	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases	bipolar cellular bud site selection|small GTPase mediated signal transduction|axial cellular bud site selection|cellular bud site selection	GTPase activity|signal transducer activity	plasma membrane|cellular bud neck
YLR450W	YLR450W	HMG2	hom	Verified	0.960534971445307	0.168393019499701	no	824	0.108982310957531	416	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at the nuclear periphery upon DNA replication stress	ergosterol biosynthetic process	hydroxymethylglutaryl-CoA reductase (NADPH) activity	nuclear envelope|integral to membrane|endoplasmic reticulum membrane
YKL050C	YKL050C	YKL050C	hom	Verified	0.960085768804348	0.168506025121144	no	825	0.119980513073259	422	NA					Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p	biological_process	molecular_function	cellular_component
YOR058C	YOR058C	ASE1	hom	Verified	0.959585786182204	0.168631862754047	no	826	0.134828123140872	485	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress	cytokinesis, completion of separation|mitotic anaphase B|microtubule bundle formation|spindle pole body separation|spindle midzone assembly|mitotic spindle stabilization|mitotic spindle elongation	microtubule binding	spindle midzone|nuclear microtubule|spindle
YKL091C	YKL091C	YKL091C	hom	Verified	0.958696525620615	0.168855824637318	no	827	0.173436792383428	601	NA	FT		NUCLEUS		Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study	biological_process	phosphatidylcholine binding|phosphatidylinositol transporter activity|phosphatidylinositol binding|phosphatidylcholine transporter activity	nucleus
YLR028C	YLR028C	ADE16	hom	Verified	0.957243498298088	0.169222183244685	no	828	0.159058348595134	512	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine	ascospore formation|'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process|aerobic respiration	phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity	cytosol
YJL049W_p	YJL049W	YJL049W	hom	Uncharacterized	0.956530545388449	0.169402129900713	no	829	0.12421190426289	416	NA	FT	PROTEIN LOCALIZATION			Putative protein of unknown function; YJL049W is a non-essential gene	biological_process	molecular_function	cellular_component
YNL078W	YNL078W	NIS1	hom	Verified	0.954392833359538	0.169942416274592	no	830	0.132148179669413	438	NA	FT	CELL CYCLE	NUCLEUS|SITE OF POLARIZED GROWTH		Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network	regulation of mitosis	molecular_function	nucleus|cellular bud neck
YLR253W_p	YLR253W	YLR253W	hom	Uncharacterized	0.953613040125886	0.170139776272642	no	831	0.171597145817247	589	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene	biological_process	molecular_function	mitochondrion
YLR306W	YLR306W	UBC12	hom	Verified	0.95124771394502	0.17073932115923	no	832	0.152995355269569	531	NA					Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes	protein neddylation	NEDD8 ligase activity	cellular_component
YLR107W	YLR107W	REX3	hom	Verified	0.946682310315255	0.171900343577267	no	833	0.155308976030865	527	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases	U5 snRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing	3'-5'-exoribonuclease activity|3'-5' exonuclease activity	nucleus|cytoplasm
YGR205W	YGR205W	TDA10	hom	Verified	0.946217031749742	0.172018950430319	no	834	0.143566274694341	503	NA	FT		NUCLEUS		ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele	biological_process	ATP binding	nucleus|cytoplasm
YMR276W	YMR276W	DSK2	hom	Verified	0.946051771908927	0.172061090343223	no	835	0.155259620587804	573	NA	FT	CELL CYCLE|PROTEOLYSIS|CYTOSKELETON ORGANIZATION	NUCLEUS		Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process|spindle pole body duplication associated with nuclear envelope	protein binding, bridging	nucleus
YLR049C_p	YLR049C	YLR049C	hom	Uncharacterized	0.945788029311369	0.172128356205138	no	836	0.109386819414363	439	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YER142C	YER142C	MAG1	hom	Verified	0.94474221987451	0.172395248404549	no	837	0.148522466640761	557	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress	base-excision repair, AP site formation|DNA dealkylation involved in DNA repair	alkylbase DNA N-glycosylase activity	nucleus
YJL106W	YJL106W	IME2	hom	Verified	0.944050171920214	0.172572005178407	no	838	0.163212779555594	539	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p	protein phosphorylation|regulation of meiosis	protein kinase activity	nucleus
YDR508C	YDR508C	GNP1	hom	Verified	0.943364176754809	0.172747330009213	no	839	0.14374958198101	514	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity|L-proline transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YGL165C_d	YGL165C	YGL165C	hom	Dubious	0.943113931555318	0.172811315269257	no	840	0.1578661773453	511	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W	Unknown	Unknown	Unknown
YDL184C	YDL184C	RPL41A	hom	Verified	0.942239298112189	0.173035069158616	no	841	0.157887064480588	506	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YMR048W	YMR048W	CSM3	hom	Verified	0.942014575729778	0.173092588753385	no	842	0.147582105202521	514	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress	DNA repair|DNA replication checkpoint|meiotic chromosome segregation|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|mitotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	molecular_function	replication fork protection complex|nucleus
YPL215W	YPL215W	CBP3	hom	Verified	0.941986011993136	0.173099900755722	no	843	0.145796318398291	517	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly	ribosome binding	integral to mitochondrial membrane|mitochondrion|mitochondrial ribosome
YOR221C	YOR221C	MCT1	hom	Verified	0.941774065378199	0.173154162903502	no	844	0.211027820047609	742	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling	fatty acid metabolic process|aerobic respiration	[acyl-carrier-protein] S-malonyltransferase activity	mitochondrion
YJR127C	YJR127C	RSF2	hom	Verified	0.941711107389913	0.173170283368274	no	845	0.128841737054253	460	NA	FT		NUCLEUS		Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YCR022C_d	YCR022C	YCR022C	hom	Dubious	0.941580515647948	0.173203724580317	no	846	0.154142828093584	546	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene	Unknown	Unknown	Unknown
YNL101W	YNL101W	AVT4	hom	Verified	0.940037145789752	0.173599253676169	no	847	0.162816386491188	569	NA	FT	VACUOLAR TRANSPORT			Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid export from vacuole	transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YBR239C_p	YBR239C	ERT1	hom	Uncharacterized	0.937085702037704	0.174357237759686	no	848	0.164847508741469	525	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM	NUCLEUS		Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition	biological_process	sequence-specific DNA binding	nucleus|cytoplasm
YKL067W	YKL067W	YNK1	hom	Verified	0.935634793681473	0.174730626953587	no	849	0.141432468092756	483	NA	FT	RESPONSE TO DNA DAMAGE|NUCLEOTIDE METABOLISM	MITOCHONDRION		Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress	nucleoside diphosphate phosphorylation|nucleoside triphosphate biosynthetic process|response to DNA damage stimulus	nucleoside diphosphate kinase activity	cytosol|mitochondrion|mitochondrial intermembrane space
YLR104W_p	YLR104W	LCL2	hom	Uncharacterized	0.933603285093844	0.175254285065558	no	850	0.173573507576304	546	NA	FT	PROTEOLYSIS			Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)	ER-associated protein catabolic process	molecular_function	cellular_component
YOL125W	YOL125W	TRM13	hom	Verified	0.933553246563043	0.175267195948598	no	851	0.13228579807708	478	NA	FT	RNA PROCESSING	NUCLEUS		2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases	tRNA methylation	tRNA methyltransferase activity	nucleus|cytoplasm
YMR104C	YMR104C	YPK2	hom	Verified	0.93175169461263	0.175732431993776	no	852	0.134727347507081	456	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication	eisosome assembly|protein phosphorylation	protein kinase activity	nucleus|cytoplasm
YJL127C-B_p	YJL127C-B	YJL127C-B	hom	Uncharacterized	0.930999424709292	0.175926930876885	no	853	0.158134871000948	543	NA					Putative protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i>	biological_process	molecular_function	cellular_component
YFL021W	YFL021W	GAT1	hom	Verified	0.929862784266904	0.17622106699577	no	854	0.144552872067776	470	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p	nitrogen catabolite activation of transcription from RNA polymerase II promoter|nitrogen catabolite activation of transcription	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity	cytosol|nucleus
YNL068C	YNL068C	FKH2	hom	Verified	0.927733826726104	0.176772828566647	no	855	0.160957264235816	599	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication	negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|negative regulation of transcription involved in G1 phase of mitotic cell cycle|Unknown|chromatin remodeling|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle	RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus
YDR126W	YDR126W	SWF1	hom	Verified	0.926498677002939	0.177093442166948	no	856	0.200171603578127	679	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|CYTOSKELETON		Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion	ascospore wall assembly|cortical actin cytoskeleton organization|establishment of cell polarity|vacuole fusion, non-autophagic|regulation of exocytosis|protein palmitoylation	palmitoyltransferase activity	integral to membrane|actin filament bundle|nuclear outer membrane-endoplasmic reticulum membrane network|actin cortical patch
YJR056C	YJR056C	YJR056C	hom	Verified	0.926366758421691	0.177127706590444	no	857	0.125047191708505	449	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YPL213W	YPL213W	LEA1	hom	Verified	0.925366028490377	0.177387771724593	no	858	0.176094829843094	648	NA	FT	RNA PROCESSING	NUCLEUS		Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein	mRNA splicing, via spliceosome	molecular_function	U2 snRNP|U2-type prespliceosome|cytoplasm
YAR023C_p	YAR023C	YAR023C	hom	Uncharacterized	0.924726720189298	0.177554038383642	no	859	0.17683932810442	613	NA					Putative integral membrane protein, member of DUP240 gene family	biological_process	molecular_function	cellular_component
YBL068W	YBL068W	PRS4	hom	Verified	0.920466231467896	0.17866458584556	no	860	0.136713205688359	492	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YPL123C	YPL123C	RNY1	hom	Verified	0.919565756289143	0.178899864211134	no	861	0.153711945957618	531	NA					Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity	cell morphogenesis|RNA catabolic process|apoptotic process	endoribonuclease activity	cytosol|extracellular region|vacuole
YOL019W-A_p	YOL019W-A	YOL019W-A	hom	Uncharacterized	0.918827551453952	0.17909288956734	no	862	0.160475552054427	513	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YDL129W	YDL129W	YDL129W	hom	Verified	0.918762785368056	0.179109830814125	no	863	0.137659834265237	440	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YDR139C	YDR139C	RUB1	hom	Verified	0.917994302720353	0.179310924293436	no	864	0.149482435641175	493	NA					Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)	protein neddylation	protein tag	cytoplasm
YLR065C	YLR065C	ENV10	hom	Verified	0.917749122399765	0.179375111965496	no	865	0.214983052659479	799	NA	FF|FT	VACUOLAR PROTEIN PROCESSING			Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene	vacuolar protein processing	molecular_function	integral to membrane
YKL097C_d	YKL097C	YKL097C	hom	Dubious	0.917728725139968	0.179380452574376	no	866	0.160809640004168	522	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species	Unknown	Unknown	Unknown
YDR133C_d	YDR133C	YDR133C	hom	Dubious	0.917411050354912	0.179463642178339	no	867	0.155046035953278	540	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C	Unknown	Unknown	Unknown
YNL104C	YNL104C	LEU4	hom	Verified	0.917077807423343	0.179550934677871	no	868	0.147705645108962	510	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication	leucine biosynthetic process	2-isopropylmalate synthase activity	mitochondrion|cytoplasm
YPL003W	YPL003W	ULA1	hom	Verified	0.916930456056937	0.179589541660613	no	869	0.183998952994961	624	NA					Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation	protein neddylation	NEDD8 activating enzyme activity	cellular_component
YOR283W	YOR283W	YOR283W	hom	Verified	0.916562046964976	0.179686089980257	no	870	0.173863646400898	576	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene	dephosphorylation	phosphatase activity	nucleus|cytoplasm
YOR084W	YOR084W	LPX1	hom	Verified	0.916384303328024	0.179732682601982	no	871	0.141986405472121	453	NA	FT	PEROXISOME ORGANIZATION			Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction	peroxisome organization	lipase activity	peroxisomal matrix
YJR084W	YJR084W	YJR084W	hom	Verified	0.915850722037584	0.179872597903093	no	872	0.15356447260481	531	NA	FT	RNA PROCESSING|SIGNALING	NUCLEUS|CHROMOSOME		Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|mRNA splicing, via spliceosome	molecular_function	transcriptionally active chromatin
YLR258W	YLR258W	GSY2	hom	Verified	0.91479374336849	0.180149960002184	no	873	0.178857866859648	620	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress	glycogen biosynthetic process	glycogen (starch) synthase activity	cytoplasm
YJL181W_p	YJL181W	YJL181W	hom	Uncharacterized	0.914498138992597	0.180227577652957	no	874	0.137913878611522	483	NA					Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YCL023C_d	YCL023C	YCL023C	hom	Dubious	0.913678244903968	0.180442969308058	no	875	0.164482380797578	538	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4	Unknown	Unknown	Unknown
YCR095C_p	YCR095C	OCA4	hom	Uncharacterized	0.912827907679132	0.180666529094027	no	876	0.178419532796011	621	NA					Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts	biological_process	molecular_function	cytoplasm
YLR366W_d	YLR366W	YLR366W	hom	Dubious	0.91084092366768	0.181189598223579	no	877	0.179635960386574	603	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A	Unknown	Unknown	Unknown
YOR054C	YOR054C	VHS3	hom	Verified	0.910744967714428	0.181214882401909	no	878	0.191739976495922	639	NA	FT	CELL CYCLE|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM			Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis	coenzyme A biosynthetic process|cellular monovalent inorganic cation homeostasis	phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity	phosphopantothenoylcysteine decarboxylase complex
YKL106C-A_p	YKL106C-A	YKL106C-A	hom	Uncharacterized	0.910227776089173	0.181351199285587	no	879	0.148608233207714	511	NA					Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi	biological_process	molecular_function	cellular_component
YIL087C	YIL087C	AIM19	hom	Verified	0.90993628690978	0.181428055758846	no	880	0.168147734032173	549	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth	biological_process	molecular_function	mitochondrion
YJR058C	YJR058C	APS2	hom	Verified	0.908819612512475	0.181722676112035	no	881	0.136210465017162	448	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YBR225W_p	YBR225W	YBR225W	hom	Uncharacterized	0.907922283101704	0.181959641858795	no	882	0.162595769681416	564	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components	biological_process	molecular_function	cellular_component
YJL145W	YJL145W	SFH5	hom	Verified	0.904873026876802	0.182766329089166	no	883	0.152143720530603	550	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress	Golgi to plasma membrane protein transport|phosphatidylinositol metabolic process|Unknown|regulation of exocytosis|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cell periphery|cytosol|plasma membrane|cortical endoplasmic reticulum
YOR051C	YOR051C	ETT1	hom	Verified	0.904082490280305	0.182975831114155	no	884	0.171937708128845	607	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	NUCLEUS		Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough	translational termination	molecular_function	nucleus
YPL159C	YPL159C	PET20	hom	Verified	0.904057067639216	0.182982570916121	no	885	0.191203496073271	634	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome	aerobic respiration	molecular_function	mitochondrion
YKR087C	YKR087C	OMA1	hom	Verified	0.903529369016398	0.183122504191499	no	886	0.179649846246013	644	NA	FT	PROTEOLYSIS	MITOCHONDRION		Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes	misfolded or incompletely synthesized protein catabolic process	metalloendopeptidase activity	mitochondrion|mitochondrial inner membrane
YGR017W_p	YGR017W	YGR017W	hom	Uncharacterized	0.902186317710132	0.183478950887651	no	887	0.145450269781314	489	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YJR055W	YJR055W	HIT1	hom	Verified	0.902101828857266	0.183501388734154	no	888	0.142469162379829	534	NA	FT		NUCLEUS		Protein of unknown function, required for growth at high temperature	biological_process	molecular_function	nucleus|cytoplasm
YLR050C_p	YLR050C	YLR050C	hom	Uncharacterized	0.901382104012732	0.183692596602909	no	889	0.178942165570365	619	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YPL193W	YPL193W	RSA1	hom	Verified	0.900918066301367	0.183815942373009	no	890	0.221365036553935	762	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly	ribosomal large subunit assembly	molecular_function	nucleoplasm
YAL024C	YAL024C	LTE1	hom	Verified	0.900703900857863	0.183872887041559	no	891	0.238368126960564	838	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION			Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint|vesicle-mediated transport	guanyl-nucleotide exchange factor activity	cellular bud
YJR103W	YJR103W	URA8	hom	Verified	0.900208182634986	0.184004736207842	no	892	0.153735762696778	475	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication	pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process	CTP synthase activity	cytosol
YBL088C	YBL088C	TEL1	hom	Verified	0.894321487140679	0.185574953318746	no	893	0.180823972110312	622	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)	double-strand break repair|histone phosphorylation|telomere maintenance|response to DNA damage stimulus|phosphorylation|DNA damage induced protein phosphorylation	protein kinase activity|telomeric DNA binding	mitochondrion|nucleus
YOL147C	YOL147C	PEX11	hom	Verified	0.892987153951105	0.18593202601504	no	894	0.166426727364919	552	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|PEROXISOME ORGANIZATION	ENDOPLASMIC RETICULUM		Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p	peroxisome fission|fatty acid oxidation	molecular_function	endoplasmic reticulum|peroxisomal membrane
YLL012W	YLL012W	YEH1	hom	Verified	0.892890100615941	0.185958014471188	no	895	0.156836811975574	513	NA	FT	LIPID METABOLISM			Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes	sterol metabolic process	sterol esterase activity	integral to membrane|lipid particle
YLR082C	YLR082C	SRL2	hom	Verified	0.891891136172797	0.186225643054466	no	896	0.184709867941783	582	NA	FT		NUCLEUS		Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation	nucleobase-containing compound metabolic process	molecular_function	nucleus|cytoplasm
YLR030W_p	YLR030W	YLR030W	hom	Uncharacterized	0.891564890105331	0.186313098016917	no	897	0.168334039928488	578	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR323C	YOR323C	PRO2	hom	Verified	0.891150788884501	0.18642414046074	no	898	0.285436243836659	1025	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis	proline biosynthetic process	glutamate-5-semialdehyde dehydrogenase activity	nucleus|cytoplasm
YDL183C	YDL183C	YDL183C	hom	Verified	0.890758498126366	0.186529372169806	no	899	0.213218850391276	692	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene	potassium ion transport|proton transport	molecular_function	integral to mitochondrial inner membrane
YHL040C	YHL040C	ARN1	hom	Verified	0.889599285878549	0.18684054490667	no	900	0.163870969554278	526	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress	siderophore transport	siderophore transmembrane transporter activity	endosome|integral to membrane|plasma membrane|cytoplasmic membrane-bounded vesicle
YNL063W	YNL063W	MTQ1	hom	Verified	0.889133182793755	0.186965753630724	no	901	0.194570555416188	687	NA	FT	TRANSLATION	MITOCHONDRION		S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene	translational readthrough	S-adenosylmethionine-dependent methyltransferase activity	mitochondrion
YOL080C	YOL080C	REX4	hom	Verified	0.888859583076484	0.187039274575906	no	902	0.166554128211599	527	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly	ribosomal large subunit assembly|rRNA processing	3'-5' exonuclease activity	nucleolus|nucleus
YML017W	YML017W	PSP2	hom	Verified	0.888485873154379	0.187139725746416	no	903	0.210697845216497	760	NA					Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing	biological_process	molecular_function	cytoplasm
YEL037C	YEL037C	RAD23	hom	Verified	0.888105372719984	0.187242036442915	no	904	0.180215359972878	597	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS|MITOCHONDRION		Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover	proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair, DNA damage recognition|ER-associated protein catabolic process|protein deglycosylation	damaged DNA binding|ubiquitin binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding, bridging	proteasome complex|mitochondrion|nucleotide-excision repair factor 2 complex
YER087W	YER087W	AIM10	hom	Verified	0.886837171667404	0.187583285814273	no	905	0.204266597310613	682	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	proline-tRNA ligase activity	mitochondrion
YOR042W	YOR042W	CUE5	hom	Verified	0.886010009298649	0.187806066781762	no	906	0.196657247736127	664	NA					Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	ubiquitin binding	cytoplasm
YPL133C	YPL133C	RDS2	hom	Verified	0.884772523792664	0.188139665686596	no	907	0.156456545127003	530	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|cellular response to xenobiotic stimulus|positive regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YDL116W	YDL116W	NUP84	hom	Verified	0.884037886450792	0.188337880655543	no	908	0.187651151631536	658	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107	double-strand break repair|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|maintenance of chromatin silencing at telomere|nuclear pore distribution|telomere tethering at nuclear periphery|response to DNA damage stimulus|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	structural constituent of nuclear pore	integral to membrane|nuclear pore outer ring|nuclear pore
YBR206W_d	YBR206W	YBR206W	hom	Dubious	0.883911404600065	0.188372020143027	no	909	0.200466262476505	681	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3	Unknown	Unknown	Unknown
YDR505C	YDR505C	PSP1	hom	Verified	0.883802206066478	0.188401497655247	no	910	0.17455788517168	560	NA	FT		MITOCHONDRION		Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|cytoplasm
YCL021W-A_p	YCL021W-A	YCL021W-A	hom	Uncharacterized	0.883690100855119	0.188431762767922	no	911	0.163836270067401	557	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDL088C	YDL088C	ASM4	hom	Verified	0.88273092805552	0.188690833804831	no	912	0.179613304319082	639	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication	nuclear pore organization|mRNA export from nucleus in response to heat stress|mitotic cell cycle spindle assembly checkpoint	nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding	nuclear pore central transport channel|integral to membrane|nuclear pore
YMR297W	YMR297W	PRC1	hom	Verified	0.880753573650756	0.189225606508194	no	913	0.151565073891808	510	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family	vacuolar protein catabolic process|phytochelatin biosynthetic process	serine-type carboxypeptidase activity	fungal-type vacuole lumen|endoplasmic reticulum|fungal-type vacuole|cytoplasm
YGR127W_p	YGR127W	YGR127W	hom	Uncharacterized	0.877219274170299	0.190183774552001	no	914	0.168612973551452	581	NA					Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response	biological_process	molecular_function	cellular_component
YNL277W-A_p	YNL277W-A	YNL277W-A	hom	Uncharacterized	0.875483267798182	0.190655505231462	no	915	0.156689938456279	508	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKL179C	YKL179C	COY1	hom	Verified	0.873158008272015	0.191288479683138	no	916	0.104689931595066	350	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function	Golgi vesicle transport	molecular_function	Golgi membrane
YMR153W	YMR153W	NUP53	hom	Verified	0.872807615629037	0.191383973961512	no	917	0.17928458201776	637	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication	positive regulation of transcription, DNA-dependent|NLS-bearing substrate import into nucleus|regulation of protein desumoylation|nuclear pore organization|protein import into nucleus|regulation of mitosis|mitotic cell cycle spindle assembly checkpoint	nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding	nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YHL007C	YHL007C	STE20	hom	Verified	0.872522390857772	0.191461729276024	no	918	0.197975098183048	698	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH		Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p	negative regulation of gene expression|osmosensory signaling pathway via Sho1 osmosensor|activation of MAPKKK activity|vacuole inheritance|protein phosphorylation|cellular bud site selection|cellular response to heat|regulation of exit from mitosis|pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|pseudohyphal growth|sterol import|stress granule assembly|invasive growth in response to glucose limitation|positive regulation of apoptotic process	histone serine kinase activity|MAP kinase kinase kinase kinase activity|protein kinase activity	incipient cellular bud site|plasma membrane|nucleus|mating projection tip
YOL163W_p	YOL163W	YOL163W	hom	Uncharacterized	0.870502001900619	0.192013062835221	no	919	0.17628022432935	587	NA					Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family	transmembrane transport	transmembrane transporter activity	integral to membrane|membrane
YNL200C	YNL200C	YNL200C	hom	Verified	0.870195774183798	0.192096712454009	no	920	0.171848606602359	581	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	nicotinamide nucleotide metabolic process	NADHX epimerase activity	mitochondrion|cytoplasm
YNL166C	YNL166C	BNI5	hom	Verified	0.87005009396046	0.192136514506253	no	921	0.159646147149495	518	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner	septin ring assembly|cytokinesis	molecular_function	cellular bud neck septin ring|cellular bud neck
YLR041W_d	YLR041W	YLR041W	hom	Dubious	0.867710504583265	0.192776416888383	no	922	0.17028895728486	615	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C	Unknown	Unknown	Unknown
YOR195W	YOR195W	SLK19	hom	Verified	0.866709422689548	0.19305062064952	no	923	0.149358834721221	544	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate	meiosis|mitotic spindle organization in nucleus	molecular_function	spindle midzone|condensed nuclear chromosome kinetochore|kinetochore|spindle
YKL129C	YKL129C	MYO3	hom	Verified	0.8665121648783	0.193104679100793	no	924	0.147657669384827	479	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION	CYTOSKELETON		One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization	bipolar cellular bud site selection|fungal-type cell wall organization|endocytosis|exocytosis|actin cortical patch localization|response to osmotic stress	microfilament motor activity	actin cortical patch
YOL037C_d	YOL037C	YOL037C	hom	Dubious	0.866390549605923	0.193138012339091	no	925	0.205632571700563	690	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W	Unknown	Unknown	Unknown
YOR351C	YOR351C	MEK1	hom	Verified	0.86618275238565	0.193194975108555	no	926	0.179829790127426	642	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	NUCLEUS		Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids	meiosis|meiotic recombination checkpoint|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	nucleus
YDR034W-B_p	YDR034W-B	YDR034W-B	hom	Uncharacterized	0.866139483098698	0.193206837665934	no	927	0.19933059094326	658	NA					Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YFR039C_p	YFR039C	YFR039C	hom	Uncharacterized	0.86352525463984	0.193924370114036	no	928	0.168345956006585	554	NA					Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces	biological_process	molecular_function	cellular_component
YLR108C	YLR108C	YLR108C	hom	Verified	0.863207101853462	0.194011804847744	no	929	0.20935516491249	689	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus
YBR050C	YBR050C	REG2	hom	Verified	0.863109311150304	0.194038684509571	no	930	0.157934992980259	498	NA	FT	TRANSCRIPTION FROM RNA POL II			Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease	negative regulation of transcription from RNA polymerase II promoter	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex
YDR436W	YDR436W	PPZ2	hom	Verified	0.862932402244811	0.194087317100859	no	931	0.187053373400905	612	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular sodium ion homeostasis	protein serine/threonine phosphatase activity	cellular_component
YMR124W_p	YMR124W	YMR124W	hom	Uncharacterized	0.86256242439676	0.194189048708678	no	932	0.178046828653987	618	NA					Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization	biological_process	molecular_function	cytoplasm
YLR102C	YLR102C	APC9	hom	Verified	0.858705918133383	0.195251392273883	no	933	0.181814296214233	651	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	chromatin assembly|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YMR223W	YMR223W	UBP8	hom	Verified	0.85866391908451	0.195262981067275	no	934	0.175281501887535	622	NA	FT	CHROMATIN ORGANIZATION|PROTEOLYSIS	NUCLEUS	HISTONE ACETYLTRANSFERASE	Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B	histone H3-K4 methylation|histone deubiquitination|histone H3-K79 methylation	ubiquitin-specific protease activity|protein complex scaffold	DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YHL002W	YHL002W	HSE1	hom	Verified	0.858381855727621	0.19534082160978	no	935	0.207664587354627	646	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes	late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding	endosome|ESCRT-0 complex
YMR151W_d	YMR151W	YIM2	hom	Dubious	0.858305687353124	0.195361844898194	no	936	0.188144398845136	627	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1	Unknown	Unknown	Unknown
YDL201W	YDL201W	TRM8	hom	Verified	0.857719984285998	0.195523551145269	no	937	0.171202818201984	557	NA	FT	RNA PROCESSING	NUCLEUS		Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p	tRNA methylation	tRNA (guanine-N7-)-methyltransferase activity	tRNA methyltransferase complex|nucleus
YLR199C	YLR199C	PBA1	hom	Verified	0.857567132829125	0.19556576514062	no	938	0.154863163712457	538	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly	proteasome assembly	molecular_function	cytoplasm
YGR092W	YGR092W	DBF2	hom	Verified	0.857227981714264	0.195659450502571	no	939	0.270221494419142	920	NA	FF|FT	CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS	SITE OF POLARIZED GROWTH|CYTOSKELETON		Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis	nuclear division|protein phosphorylation|vacuolar acidification	protein serine/threonine kinase activity|protein kinase activity	spindle pole body|cellular bud neck
YPR026W	YPR026W	ATH1	hom	Verified	0.857124668550096	0.195687994613561	no	940	0.174610460000088	579	NA	FT	CARBOHYDRATE METABOLISM			Acid trehalase required for utilization of extracellular trehalose	trehalose catabolic process|response to stress	alpha,alpha-trehalase activity	fungal-type cell wall|cell wall-bounded periplasmic space|fungal-type vacuole
YLR422W_p	YLR422W	YLR422W	hom	Uncharacterized	0.856614482285213	0.19582898963962	no	941	0.207248230437259	718	NA					Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein	biological_process	molecular_function	cytoplasm
YLR011W	YLR011W	LOT6	hom	Verified	0.854992241726332	0.196277721391193	no	942	0.165104286837756	518	NA	FT	PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions	cellular response to oxidative stress|cytoplasmic sequestering of transcription factor	NAD(P)H dehydrogenase (quinone) activity|transcription factor binding	cytosol|nucleus|cytoplasm
YJL122W	YJL122W	ALB1	hom	Verified	0.854840699221488	0.196319671730717	no	943	0.167340851774603	586	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p	ribosomal large subunit biogenesis	molecular_function	ribosome|nucleus|cytoplasm
YDL154W	YDL154W	MSH5	hom	Verified	0.853547939139858	0.196677757411782	no	944	0.17929879475333	630	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans	reciprocal meiotic recombination	molecular_function	nucleus
YDR374C_p	YDR374C	YDR374C	hom	Uncharacterized	0.852611691651556	0.19693733839377	no	945	0.170374897251466	572	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL074C	YNL074C	MLF3	hom	Verified	0.85241743131772	0.196991224361985	no	946	0.180844179189869	595	NA					Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide	response to drug	molecular_function	cytoplasm
YOR050C_d	YOR050C	YOR050C	hom	Dubious	0.852260886897084	0.197034654787885	no	947	0.171334628762693	579	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable	Unknown	Unknown	Unknown
YMR066W	YMR066W	SOV1	hom	Verified	0.851964427516549	0.197116917973485	no	948	0.21679516306265	737	NA	FT		MITOCHONDRION		Mitochondrial protein of unknown function	biological_process	molecular_function	mitochondrion
YJL118W	YJL118W	YJL118W	hom	Verified	0.851763741576311	0.197172617210949	no	949	0.176542532897474	590	NA					Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein	biological_process	molecular_function	ribosome
YBR165W	YBR165W	UBS1	hom	Verified	0.851002072632686	0.197384100722735	no	950	0.164216959482845	551	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity	protein export from nucleus|protein ubiquitination	molecular_function	nucleus
YPR004C	YPR004C	AIM45	hom	Verified	0.850351262859138	0.197564911934565	no	951	0.19546745196609	679	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YDR030C	YDR030C	RAD28	hom	Verified	0.849825399231048	0.197711083099157	no	952	0.197921031896431	654	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair	DNA repair	molecular_function	nucleus
YDR011W	YDR011W	SNQ2	hom	Verified	0.848849587124274	0.197982496852432	no	953	0.23684064149909	818	NA	FF|FT	NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species	response to drug	xenobiotic-transporting ATPase activity	mitochondrion|integral to membrane|plasma membrane
YMR280C	YMR280C	CAT8	hom	Verified	0.848034243039184	0.198209450280069	no	954	0.162989021403107	610	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of glyoxylate cycle by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YBL024W	YBL024W	NCL1	hom	Verified	0.84678536119591	0.198557384579323	no	955	0.235186845506393	754	NA	FT	RNA PROCESSING	NUCLEUS		S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120	tRNA methylation	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YOR305W	YOR305W	RRG7	hom	Verified	0.844866958363239	0.199092562223903	no	956	0.184317646577822	651	NA	FT		MITOCHONDRION		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene	biological_process	molecular_function	mitochondrion
YER017C	YER017C	AFG3	hom	Verified	0.844205890448375	0.199277181761827	no	957	0.234482723621199	791	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease; mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging	proteolysis|signal peptide processing|protein complex assembly|protein import into mitochondrial intermembrane space	metallopeptidase activity|protein binding|ATPase activity	mitochondrion|mitochondrial inner boundary membrane|mitochondrial inner membrane|m-AAA complex
YIL057C	YIL057C	RGI2	hom	Verified	0.843257510169704	0.199542220348269	no	958	0.216710709674006	738	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose	energy reserve metabolic process	molecular_function	cytoplasm
YNL141W	YNL141W	AAH1	hom	Verified	0.843077783983946	0.199592471332245	no	959	0.200307226845037	711	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome	adenine catabolic process|hypoxanthine salvage|purine-containing compound salvage	adenine deaminase activity	nucleus|cytoplasm
YJR052W	YJR052W	RAD7	hom	Verified	0.843049526154303	0.199600372842227	no	960	0.197002308315823	662	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	damaged DNA binding|ubiquitin-protein ligase activity|DNA-dependent ATPase activity	nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YLR216C	YLR216C	CPR6	hom	Verified	0.842718354067599	0.199692989863232	no	961	0.164511927918926	549	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress	protein folding|protein refolding	unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity	cytoplasm
YHR093W_d	YHR093W	AHT1	hom	Dubious	0.842376195196474	0.199788706648242	no	962	0.193139046179469	633	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region	Unknown	Unknown	Unknown
YDR067C_p	YDR067C	OCA6	hom	Uncharacterized	0.842327126965415	0.199802435438499	no	963	0.221616252141362	747	NA					Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT	biological_process	molecular_function	cytoplasm
YJL196C	YJL196C	ELO1	hom	Verified	0.841690236452047	0.199980682382394	no	964	0.170560474499698	577	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication	fatty acid elongation, unsaturated fatty acid	fatty acid elongase activity	integral to membrane|membrane
YOR238W_p	YOR238W	YOR238W	hom	Uncharacterized	0.841593710787603	0.200007705421073	no	965	0.172192096126698	579	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YLL005C	YLL005C	SPO75	hom	Verified	0.839303274819372	0.200649573004228	no	966	0.166573220872359	554	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis	ascospore wall assembly|ascospore formation	molecular_function	integral to membrane
YML020W_p	YML020W	YML020W	hom	Uncharacterized	0.838503625807798	0.200873956103425	no	967	0.199280799984011	710	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJR048W	YJR048W	CYC1	hom	Verified	0.836987600409262	0.201299768941213	no	968	0.168573127754575	572	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c	electron carrier activity	mitochondrion|mitochondrial intermembrane space
YDR340W_d	YDR340W	YDR340W	hom	Dubious	0.83680047147357	0.201352366174939	no	969	0.178309005250834	601	NA					Putative protein of unknown function	Unknown	Unknown	Unknown
YDR098C	YDR098C	GRX3	hom	Verified	0.835919011237665	0.201600233231413	no	970	0.187259869946468	637	NA	FT	ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36	cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization	disulfide oxidoreductase activity	cytosol|nucleus
YPR052C	YPR052C	NHP6A	hom	Verified	0.835744317788304	0.201649378810769	no	971	0.189114346353415	655	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	mismatch repair|DNA replication-independent nucleosome organization|RNA polymerase II transcriptional preinitiation complex assembly|RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling	nucleosome binding|sequence-specific DNA binding|DNA binding, bending	MutSalpha complex|nucleus
YLR205C	YLR205C	HMX1	hom	Verified	0.835724962967692	0.201654824241112	no	972	0.169965335401204	554	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants	response to oxidative stress|cellular iron ion homeostasis|heme catabolic process	heme oxygenase (decyclizing) activity	endoplasmic reticulum|membrane|nuclear outer membrane
YJL059W	YJL059W	YHC3	hom	Verified	0.835186312386091	0.20180640756872	no	973	0.188579979688759	636	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)	basic amino acid transport|regulation of intracellular pH|arginine transport	molecular_function	integral to membrane|fungal-type vacuole
YOR214C_p	YOR214C	YOR214C	hom	Uncharacterized	0.834671438660157	0.20195136353683	no	974	0.19563432597579	655	NA					Putative protein of unknown function; YOR214C is not an essential gene	biological_process	molecular_function	fungal-type cell wall
YFL055W	YFL055W	AGP3	hom	Verified	0.832940598026113	0.202439115827428	no	975	0.189896397717058	638	NA	FT		PLASMA MEMBRANE		Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YBL028C	YBL028C	YBL028C	hom	Verified	0.832825152909645	0.202471673392627	no	976	0.225643329558366	723	NA	FT		NUCLEUS		Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YGL051W	YGL051W	MST27	hom	Verified	0.828634547465785	0.203655616422787	no	977	0.174581965779057	563	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE		Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles	vesicle organization	molecular_function	integral to membrane|Golgi apparatus|endoplasmic reticulum|plasma membrane
YMR118C_p	YMR118C	SHH3	hom	Uncharacterized	0.827955651638785	0.203847808018611	no	978	0.181749660312185	612	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase	biological_process	molecular_function	integral to membrane
YPR159W	YPR159W	KRE6	hom	Verified	0.827765829165769	0.20390156502696	no	979	0.237638989771565	799	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p	fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process	glucosidase activity	integral to endoplasmic reticulum membrane|integral to membrane|site of polarized growth|transport vesicle|plasma membrane
YER113C	YER113C	TMN3	hom	Verified	0.827551209673409	0.203962354632388	no	980	0.194987939148172	691	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation	cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|invasive growth in response to glucose limitation	molecular_function	COPI-coated vesicle|integral to membrane|Golgi apparatus
YDR131C_p	YDR131C	YDR131C	hom	Uncharacterized	0.826706948990747	0.204201590871785	no	981	0.167423582456342	570	NA	FT	PROTEOLYSIS			F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YNR014W_p	YNR014W	YNR014W	hom	Uncharacterized	0.825628667516811	0.204507383948294	no	982	0.220608148409334	736	NA					Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YJR099W	YJR099W	YUH1	hom	Verified	0.825158133829883	0.20464090937014	no	983	0.185234104495283	608	NA	FT	PROTEOLYSIS			Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p	protein deubiquitination	ubiquitin-specific protease activity	cytoplasm
YKL202W_d	YKL202W	YKL202W	hom	Dubious	0.824926616284518	0.204706627160222	no	984	0.169922897376106	570	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR215W	YMR215W	GAS3	hom	Verified	0.824512245142738	0.204824280493245	no	985	0.19224008056632	646	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation	biological_process	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane|plasma membrane
YCR051W_p	YCR051W	YCR051W	hom	Uncharacterized	0.823172996116704	0.205204811406783	no	986	0.201746470102424	704	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YBL039W-B_p	YBL039W-B	YBL039W-B	hom	Uncharacterized	0.822647626843331	0.205354203174055	no	987	0.18822967628407	639	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGL178W	YGL178W	MPT5	hom	Verified	0.821394562529273	0.205710779882322	no	988	0.181457690711008	625	NA	FT	TRANSLATION			mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity	negative regulation of translation|negative regulation of translational initiation|Unknown	mRNA binding|protein binding, bridging	cytoplasm
YMR172C-A_d	YMR172C-A	YMR172C-A	hom	Dubious	0.82116700939683	0.205775572661306	no	989	0.202898667711885	704	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHL043W	YHL043W	ECM34	hom	Verified	0.820517904643866	0.205960463280357	no	990	0.174753270785597	577	NA	FT	CELL WALL ORG/BIOGENESIS			Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	fungal-type cell wall organization	molecular_function	cellular_component
YDR369C	YDR369C	XRS2	hom	Verified	0.819869056265003	0.206145379314965	no	991	0.219579315385869	763	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling	double-strand break repair via nonhomologous end joining|meiotic DNA double-strand break formation|base-excision repair|telomere maintenance|sporulation resulting in formation of a cellular spore|double-strand break repair via break-induced replication	single-stranded telomeric DNA binding|protein binding, bridging|DNA binding|double-stranded telomeric DNA binding|telomeric DNA binding|G-quadruplex DNA binding	nucleus|Mre11 complex
YGR247W	YGR247W	CPD1	hom	Verified	0.819846467724637	0.206151818621195	no	992	0.199811697872014	687	NA	FT	NUCLEOTIDE METABOLISM	GOLGI APPARATUS		Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress	cyclic nucleotide metabolic process	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	clathrin-coated vesicle
YMR210W	YMR210W	YMR210W	hom	Verified	0.819686876240141	0.206197316699796	no	993	0.171624609474237	532	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification	medium-chain fatty acid biosynthetic process	transferase activity, transferring acyl groups	cellular_component
YBL005W	YBL005W	PDR3	hom	Verified	0.81967641027443	0.206200300659267	no	994	0.200947410500605	692	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YML052W	YML052W	SUR7	hom	Verified	0.819216033145223	0.20633158446141	no	995	0.175522909563356	607	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants	endocytosis|ascospore formation	molecular_function	cell cortex|eisosome|mitochondrion|membrane raft|integral to membrane|plasma membrane|actin cortical patch
YOR252W	YOR252W	TMA16	hom	Verified	0.819069189974709	0.206373469525908	no	996	0.194042941241363	655	NA	FT		NUCLEUS		Protein of unknown function that associates with ribosomes	biological_process	molecular_function	ribosome|nucleus
YLR382C	YLR382C	NAM2	hom	Verified	0.818102342586036	0.206649375680747	no	997	0.228774765393765	758	NA	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance	Group I intron splicing|leucyl-tRNA aminoacylation|mitochondrial translation	mRNA binding|leucine-tRNA ligase activity	mitochondrion
YKR075C_p	YKR075C	YKR075C	hom	Uncharacterized	0.817338991312542	0.206867365034188	no	998	0.212544638334311	729	NA	FT		NUCLEUS		Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YAL059W	YAL059W	ECM1	hom	Verified	0.816575155844781	0.20708562883754	no	999	0.177610657205251	593	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|CELL WALL ORG/BIOGENESIS	NUCLEUS		Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm	fungal-type cell wall organization|ribosomal large subunit export from nucleus	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YAL008W	YAL008W	FUN14	hom	Verified	0.816297423385271	0.20716502385649	no	1000	0.226753680104808	730	NA	FT		MITOCHONDRION		Mitochondrial protein of unknown function	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YLR353W	YLR353W	BUD8	hom	Verified	0.813713234506943	0.207904625327045	no	1001	0.166476352260172	568	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole	pseudohyphal growth|cellular bud site selection	molecular_function	incipient cellular bud site|plasma membrane|cellular bud tip
YMR230W-A_p	YMR230W-A	YMR230W-A	hom	Uncharacterized	0.813553439001515	0.207950410338182	no	1002	0.206147834743055	711	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR139W	YMR139W	RIM11	hom	Verified	0.812823949463672	0.208159501128147	no	1003	0.164591371631402	567	NA	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION			Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress	proteolysis|ascospore formation|protein phosphorylation|response to stress	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YLR290C_p	YLR290C	YLR290C	hom	Uncharacterized	0.812112456620074	0.208363553059813	no	1004	0.175082645986799	573	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene	biological_process	molecular_function	mitochondrion
YCR067C	YCR067C	SED4	hom	Verified	0.811911227783049	0.208421285694344	no	1005	0.206484819365771	661	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p	positive regulation of GTPase activity|regulation of COPII vesicle coating	Sar GTPase activator activity	integral to endoplasmic reticulum membrane
YML032C	YML032C	RAD52	hom	Verified	0.811715411507208	0.20847747451884	no	1006	0.206851986396073	688	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis	postreplication repair|telomere maintenance via recombination|meiotic joint molecule formation|meiotic DNA recombinase assembly|DNA recombinase assembly|DNA strand renaturation|double-strand break repair via synthesis-dependent strand annealing|double-strand break repair via single-strand annealing|double-strand break repair via break-induced replication	recombinase activity	nuclear chromosome|nucleus
YGL072C_d	YGL072C	YGL072C	hom	Dubious	0.810443825223161	0.208842569233699	no	1007	0.244529663536727	870	NA	FF				Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	Unknown	Unknown	Unknown
YGL133W	YGL133W	ITC1	hom	Verified	0.809622141157791	0.209078689366469	no	1008	0.213371621429338	732	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex	negative regulation of transcription from RNA polymerase II promoter by pheromones|chromatin remodeling|chromatin silencing at telomere	molecular_function	chromatin accessibility complex
YGL259W_p	YGL259W	YPS5	hom	Uncharacterized	0.809209718408759	0.209197262899949	no	1009	0.196234125148512	665	NA	FT	PROTEOLYSIS			Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p	biological_process	aspartic-type endopeptidase activity	cellular_component
YLR367W	YLR367W	RPS22B	hom	Verified	0.808004073495091	0.209544118581652	no	1010	0.200076445698777	681	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YOR245C	YOR245C	DGA1	hom	Verified	0.807934317442979	0.209564197261376	no	1011	0.196020628296125	632	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles	lipid storage|triglyceride biosynthetic process	diacylglycerol O-acyltransferase activity	integral to membrane|lipid particle
YJL007C_d	YJL007C	YJL007C	hom	Dubious	0.806964768378252	0.209843390778926	no	1012	0.205426859843463	670	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNR061C	YNR061C	YNR061C	hom	Verified	0.806845962534792	0.209877617406504	no	1013	0.19479996248095	672	NA					Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YJR088C	YJR088C	EMC2	hom	Verified	0.80549784701277	0.210266224137094	no	1014	0.182152920765479	639	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YIL119C	YIL119C	RPI1	hom	Verified	0.805254075065064	0.210336538732572	no	1015	0.192998404454983	667	NA	FT	SIGNALING	NUCLEUS		Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF	fungal-type cell wall biogenesis|Ras protein signal transduction|positive regulation of transcription from RNA polymerase II promoter	small GTPase regulator activity	nucleus
YHR013C	YHR013C	ARD1	hom	Verified	0.805146093457163	0.210367689808791	no	1016	0.210352615071716	750	NA	FT	CHROMATIN ORGANIZATION		RIBOSOME	Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress	histone acetylation|N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	cytosolic ribosome|NatA complex
YOR297C	YOR297C	TIM18	hom	Verified	0.804565966957236	0.210535093972449	no	1017	0.176903331191709	590	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex	cellular response to oxidative stress|protein import into mitochondrial inner membrane|apoptotic process|response to acid|response to osmotic stress|response to arsenic-containing substance	protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YKL155C	YKL155C	RSM22	hom	Verified	0.804437303188547	0.210572232413627	no	1018	0.212992163170547	727	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase	mitochondrial translation	structural constituent of ribosome|S-adenosylmethionine-dependent methyltransferase activity	mitochondrion|mitochondrial small ribosomal subunit
YDL036C	YDL036C	PUS9	hom	Verified	0.804356574254339	0.210595536559998	no	1019	0.19040440872753	599	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|nucleus|cytoplasm
YGL003C	YGL003C	CDH1	hom	Verified	0.80409001791611	0.21067249453799	no	1020	0.218327607529524	764	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p	activation of mitotic anaphase-promoting complex activity|negative regulation of spindle pole body separation|positive regulation of mitotic metaphase/anaphase transition|Unknown|regulation of cell size	anaphase-promoting complex binding|cyclin binding|ubiquitin-protein ligase activator activity	nucleus|anaphase-promoting complex|cytoplasm
YOL154W	YOL154W	ZPS1	hom	Verified	0.802563256280303	0.21111360652534	no	1021	0.182277360247876	596	NA					Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH	biological_process	molecular_function	fungal-type cell wall|fungal-type vacuole
YDL179W	YDL179W	PCL9	hom	Verified	0.801182218240741	0.211513081928006	no	1022	0.218780325082728	738	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p	regulation of establishment or maintenance of cell polarity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|cellular bud neck
YGL136C	YGL136C	MRM2	hom	Verified	0.801180187431469	0.211513669680221	no	1023	0.18091019242163	609	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	MITOCHONDRION		Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ	rRNA methylation	rRNA (uridine-2'-O-)-methyltransferase activity	mitochondrion
YKR044W	YKR044W	UIP5	hom	Verified	0.799429988621219	0.212020563711403	no	1024	0.201678318608362	679	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates	biological_process	molecular_function	nuclear envelope
YML014W	YML014W	TRM9	hom	Verified	0.798396136718654	0.212320322234329	no	1025	0.187024509872384	642	NA	FT	RNA PROCESSING	NUCLEUS		tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses	chronological cell aging|tRNA methylation|tRNA wobble uridine modification|response to stress	tRNA (uracil) methyltransferase activity	nucleus|cytoplasm
YOL039W	YOL039W	RPP2A	hom	Verified	0.797887119484313	0.212467999360218	no	1026	0.23314899520753	787	NA	FT	TRANSLATION		RIBOSOME	Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	translational elongation|cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YMR015C	YMR015C	ERG5	hom	Verified	0.796944864246414	0.212741526681629	no	1027	0.262507188862365	937	NA	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM		C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs	ergosterol biosynthetic process	C-22 sterol desaturase activity	endoplasmic reticulum
YFL007W	YFL007W	BLM10	hom	Verified	0.796017680545398	0.213010879458397	no	1028	0.215416369426898	740	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200	proteasome assembly|regulation of proteasomal protein catabolic process	proteasome binding|peptidase activator activity	proteasome core complex|proteasome complex|integral to membrane|nucleus
YDR068W	YDR068W	DOS2	hom	Verified	0.794993875588977	0.213308532358981	no	1029	0.183786340747158	640	NA					Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YAL007C	YAL007C	ERP2	hom	Verified	0.794354897466643	0.213494426613262	no	1030	0.214656559470871	713	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles	ER to Golgi vesicle-mediated transport	molecular_function	ER to Golgi transport vesicle
YBL055C	YBL055C	YBL055C	hom	Verified	0.793888242274065	0.213630247576119	no	1031	0.192573905649551	652	NA	FT	RESPONSE TO OXIDATIVE STRESS			3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases	cellular response to oxidative stress|apoptotic DNA fragmentation	3'-5'-exodeoxyribonuclease activity|endonuclease activity	cytoplasm
YDR061W_p	YDR061W	YDR061W	hom	Uncharacterized	0.793719261817596	0.213679442100981	no	1032	0.219703411503318	724	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance	biological_process	molecular_function	mitochondrion
YDL135C	YDL135C	RDI1	hom	Verified	0.793717074694637	0.213680078871567	no	1033	0.179645669722322	563	NA	FT	MEMBRANE ORGANIZATION|SIGNALING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress	regulation of vacuole fusion, non-autophagic|actin filament organization|small GTPase mediated signal transduction	Rho GDP-dissociation inhibitor activity	cytosol|plasma membrane|cellular bud neck|cellular bud tip
YBR296C	YBR296C	PHO89	hom	Verified	0.793339278936413	0.213790088919705	no	1034	0.231204869967367	787	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification	phosphate ion transport|transmembrane transport	sodium:inorganic phosphate symporter activity	integral to membrane|plasma membrane
YHR130C_d	YHR130C	YHR130C	hom	Dubious	0.793215261858295	0.213826208544312	no	1035	0.219355463827428	738	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL162C_d	YDL162C	YDL162C	hom	Dubious	0.792764864181788	0.213957415483035	no	1036	0.212177692445903	707	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly	Unknown	Unknown	Unknown
YKL171W	YKL171W	NNK1	hom	Verified	0.791696734927463	0.214268763298841	no	1037	0.180766965882881	595	NA	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION			Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm	proteolysis|protein phosphorylation	protein kinase activity	cytoplasm
YLR263W	YLR263W	RED1	hom	Verified	0.791533795063644	0.214316281617924	no	1038	0.186053556222128	633	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p	synaptonemal complex assembly|meiotic recombination checkpoint|positive regulation of catalytic activity	chromatin DNA binding|structural molecule activity	lateral element
YGR155W	YGR155W	CYS4	hom	Verified	0.789981155727817	0.214769386803295	no	1039	0.213818961579751	723	NA	FT	KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM	MITOCHONDRION		Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria	cysteine biosynthetic process from serine|hydrogen sulfide biosynthetic process|cysteine biosynthetic process via cystathionine|transsulfuration|traversing start control point of mitotic cell cycle	cystathionine beta-synthase activity	mitochondrion|cytoplasm
YOL160W_d	YOL160W	YOL160W	hom	Dubious	0.789690523234307	0.214854263595285	no	1040	0.179992845372567	569	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL199C_d	YGL199C	YGL199C	hom	Dubious	0.789367994694946	0.214948478167708	no	1041	0.184357734681707	606	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W	Unknown	Unknown	Unknown
YMR150C	YMR150C	IMP1	hom	Verified	0.789100850849804	0.215026532350585	no	1042	0.199718485042216	622	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	protein processing involved in protein targeting to mitochondrion	endopeptidase activity	mitochondrion|mitochondrial inner membrane peptidase complex
YKL220C	YKL220C	FRE2	hom	Verified	0.7875605464378	0.215476899946977	no	1043	0.185787433117621	617	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YPL267W	YPL267W	ACM1	hom	Verified	0.786143090045832	0.215891831184613	no	1044	0.224454119309621	787	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS		Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	ubiquitin-protein ligase inhibitor activity	nucleus|cytoplasm
YGR044C	YGR044C	RME1	hom	Verified	0.785109822826225	0.216194590485703	no	1045	0.144569096274424	521	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION	NUCLEUS		Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription during meiosis|negative regulation of meiosis|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YIL099W	YIL099W	SGA1	hom	Verified	0.784327073714434	0.216424108647085	no	1046	0.210086667529056	688	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation	ascospore formation|glycogen catabolic process	glucan 1,4-alpha-glucosidase activity	fungal-type vacuole
YHR022C-A_p	YHR022C-A	YHR022C-A	hom	Uncharacterized	0.783566657153166	0.216647213421971	no	1047	0.209644255764585	733	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YKL043W	YKL043W	PHD1	hom	Verified	0.781571651353854	0.217233176275783	no	1048	0.189195870469542	586	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication	pseudohyphal growth|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YPL115C	YPL115C	BEM3	hom	Verified	0.780258064330041	0.21761949559968	no	1049	0.244840979448694	842	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly	negative regulation of Rho protein signal transduction|establishment of cell polarity	Rho GTPase activator activity|phosphatidylinositol-3-phosphate binding	cell cortex|incipient cellular bud site|mating projection tip|cytoplasm|cellular bud tip
YOL153C	YOL153C	YOL153C	hom	pseudogene	0.780020801126279	0.217689315759308	no	1050	0.182672935959516	598	NA					Hypothetical protein	biological_process	molecular_function	cellular_component
YEL066W	YEL066W	HPA3	hom	Verified	0.780013713771261	0.21769140157546	no	1051	0.163971195300856	572	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro	D-amino acid metabolic process	D-amino-acid N-acetyltransferase activity	nucleus|cytoplasm
YKL118W_d	YKL118W	YKL118W	hom	Dubious	0.779299174989764	0.217901750278971	no	1052	0.313566309098228	1033	NA	FF				Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2	Unknown	Unknown	Unknown
YDL039C	YDL039C	PRM7	hom	Verified	0.77859846337339	0.218108142272286	no	1053	0.212487017312246	677	NA					Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements	conjugation with cellular fusion	molecular_function	integral to membrane
YOL060C	YOL060C	MAM3	hom	Verified	0.778389287314975	0.218169776132062	no	1054	0.204676031112931	728	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS			Protein required for normal mitochondrial morphology, has similarity to hemolysins	cellular manganese ion homeostasis|mitochondrion organization	molecular_function	fungal-type vacuole membrane|integral to membrane
YDR417C_d	YDR417C	YDR417C	hom	Dubious	0.777810692562763	0.218340311717437	no	1055	0.225714445524937	750	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W	Unknown	Unknown	Unknown
YFL056C	YFL056C	AAD6	hom	Verified	0.777790125242647	0.218346375162572	no	1056	0.212428107404937	723	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YML034W	YML034W	SRC1	hom	Verified	0.776042167881341	0.21886204423643	no	1057	0.250971931221867	878	NA	FF|FT	CELL CYCLE|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance	maintenance of rDNA|mitotic sister chromatid segregation	molecular_function	nuclear envelope
YOR318C_d	YOR318C	YOR318C	hom	Dubious	0.774168009888791	0.219415721647057	no	1058	0.212670834713769	763	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo	Unknown	Unknown	Unknown
YGR025W_d	YGR025W	YGR025W	hom	Dubious	0.77310900254207	0.219728936836924	no	1059	0.187962476164664	618	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR162W	YGR162W	TIF4631	hom	Verified	0.772567435236585	0.219889211559481	no	1060	0.229536193314844	806	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION	MITOCHONDRION	RIBOSOME	Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication	translational initiation|ribosomal large subunit biogenesis|stress granule assembly	translation initiation factor activity	mitochondrion|ribosome|eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YNL196C_p	YNL196C	SLZ1	hom	Uncharacterized	0.772179584903291	0.220004035565192	no	1061	0.23004932744978	823	NA					Sporulation-specific protein with a leucine zipper motif	biological_process	molecular_function	cellular_component
YHL037C_d	YHL037C	YHL037C	hom	Dubious	0.77189948795113	0.220086980316854	no	1062	0.204897274377496	670	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL096W	YKL096W	CWP1	hom	Verified	0.769870787801918	0.220688271909314	no	1063	0.201264209223471	685	NA	FT	MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance	fungal-type cell wall organization|ascospore-type prospore membrane assembly	structural constituent of cell wall	fungal-type cell wall|cellular birth scar|prospore membrane
YMR007W_d	YMR007W	YMR007W	hom	Dubious	0.769520681864695	0.220792135819785	no	1064	0.181249709264319	636	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL170W	YDL170W	UGA3	hom	Verified	0.769191786452345	0.220889732820451	no	1065	0.215614995757659	699	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus	nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process	sequence-specific DNA binding transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YPR133W-A	YPR133W-A	TOM5	hom	Verified	0.766349894271541	0.221734068944991	no	1066	0.215145972890538	722	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore	mitochondrial outer membrane translocase complex assembly|protein targeting to mitochondrion	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YJL128C	YJL128C	PBS2	hom	Verified	0.76552333776664	0.221979987471141	no	1067	0.25746054140501	911	NA	FF|FT	PROTEIN LOCALIZATION|SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition	activation of MAPK activity involved in osmosensory signaling pathway|actin filament organization|MAPK import into nucleus involved in osmosensory signaling pathway|protein phosphorylation|hyperosmotic response|osmosensory signaling pathway|cellular response to heat	MAP-kinase scaffold activity|MAP kinase kinase activity|protein kinase activity	cellular bud neck|cytoplasm|cellular bud tip
YDR241W_d	YDR241W	BUD26	hom	Dubious	0.765350526938308	0.22203142212454	no	1068	0.233137863036383	804	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YDR175C	YDR175C	RSM24	hom	Verified	0.764467350168046	0.222294393183609	no	1069	0.232517409837237	797	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YNR023W	YNR023W	SNF12	hom	Verified	0.763382962231626	0.222617518950029	no	1070	0.404522553112834	1341	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive	positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex
YPL049C	YPL049C	DIG1	hom	Verified	0.76298512083533	0.222736134779553	no	1071	0.250036175921781	888	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p	negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown	DNA binding|transcription factor binding	nucleus
YNR021W_p	YNR021W	YNR021W	hom	Uncharacterized	0.762977114397806	0.222738522256846	no	1072	0.20995423350753	691	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YHR131C_p	YHR131C	YHR131C	hom	Uncharacterized	0.76221602933412	0.222965540373065	no	1073	0.195646151718779	624	NA					Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study	biological_process	molecular_function	cytoplasm
YKR054C	YKR054C	DYN1	hom	Verified	0.760157290049112	0.223580285592076	no	1074	0.193081166549568	636	NA	FT	CELL CYCLE|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p	nuclear migration along microtubule|establishment of mitotic spindle orientation|mitotic spindle elongation|mitotic sister chromatid segregation	microtubule motor activity	cytoplasmic dynein complex|cell cortex|cytoplasmic microtubule|spindle pole body|astral microtubule
YDR309C	YDR309C	GIC2	hom	Verified	0.759141638179476	0.223883916764396	no	1075	0.206517565969915	711	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region	regulation of exit from mitosis|establishment of cell polarity|axial cellular bud site selection|Rho protein signal transduction	Rho GTPase binding|Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding	incipient cellular bud site|actin cap|plasma membrane|mating projection tip|cellular bud tip
YBL027W	YBL027W	RPL19B	hom	Verified	0.759135643489889	0.223885709584285	no	1076	0.210704871323429	715	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR094W_d	YDR094W	YDR094W	hom	Dubious	0.758356021662005	0.224118939050597	no	1077	0.193110911040889	631	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2	Unknown	Unknown	Unknown
YMR100W	YMR100W	MUB1	hom	Verified	0.757874228533258	0.224263139886214	no	1078	0.242189241750185	805	NA	FT	CELL DIVISION			MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene	regulation of cell budding|protein monoubiquitination	molecular_function	cellular_component
YOL065C	YOL065C	INP54	hom	Verified	0.757478558058391	0.224381603568642	no	1079	0.194000485518343	650	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins	phosphatidylinositol dephosphorylation	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	endoplasmic reticulum
YPL121C	YPL121C	MEI5	hom	Verified	0.756213871541103	0.22476048863342	no	1080	0.195829034831365	642	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p	meiotic DNA recombinase assembly|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YAR003W	YAR003W	SWD1	hom	Verified	0.755495256286843	0.224975938770192	no	1081	0.258585418382509	902	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7	histone H3-K4 methylation|telomere maintenance|regulation of transcription, DNA-dependent|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YOR197W	YOR197W	MCA1	hom	Verified	0.754981143177049	0.225130148320244	no	1082	0.206971081234839	709	NA	FT	PROTEOLYSIS	NUCLEUS		Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization	misfolded or incompletely synthesized protein catabolic process|apoptotic process	cysteine-type peptidase activity	nucleus
YGR041W	YGR041W	BUD9	hom	Verified	0.753643164395819	0.225531759097559	no	1083	0.195563996282209	641	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole	cellular bud site selection	molecular_function	plasma membrane|cellular bud neck
YER028C	YER028C	MIG3	hom	Verified	0.753313664491257	0.225630724732555	no	1084	0.222115877579821	749	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication	cellular response to UV|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|response to DNA damage stimulus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nuclear chromatin
YHR046C	YHR046C	INM1	hom	Verified	0.753003947821817	0.225723770852296	no	1085	0.239281862675237	821	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	NUCLEUS		Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate	inositol phosphate dephosphorylation	inositol monophosphate 1-phosphatase activity	nucleus|cytoplasm
YIL032C_d	YIL032C	YIL032C	hom	Dubious	0.752862277696361	0.22576633910038	no	1086	0.240331464189608	804	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR125C	YOR125C	CAT5	hom	Verified	0.752805613468165	0.225783366522453	no	1087	0.214246418565464	719	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation	ubiquinone biosynthetic process	monooxygenase activity	mitochondrion|mitochondrial inner membrane
YPR156C	YPR156C	TPO3	hom	Verified	0.752361144132757	0.225916953349737	no	1088	0.207644455813633	740	NA	FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication	spermine transport	spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YLR093C	YLR093C	NYV1	hom	Verified	0.750085474692591	0.226601613572474	no	1089	0.218764590562233	725	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane	vesicle-mediated transport|vacuole fusion, non-autophagic|vesicle fusion	SNAP receptor activity	SNARE complex|fungal-type vacuole membrane
YPL098C	YPL098C	MGR2	hom	Verified	0.749689194398942	0.226720958485528	no	1090	0.253349710994762	866	NA	FT		MITOCHONDRION		Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype)	protein import into mitochondrial matrix	molecular_function	mitochondrial inner membrane presequence translocase complex
YMR148W	YMR148W	OSW5	hom	Verified	0.748734273454311	0.227008690889567	no	1091	0.178108306406066	587	NA					Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion	biological_process	molecular_function	integral to membrane
YLR218C	YLR218C	COA4	hom	Verified	0.748620742765821	0.227042913126809	no	1092	0.211220830427384	713	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION		Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors	mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain complex assembly	molecular_function	nucleus|mitochondrial intermembrane space|cytoplasm
YKR045C_p	YKR045C	YKR045C	hom	Uncharacterized	0.748093469121482	0.227201890509629	no	1093	0.227916591234946	762	NA					Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YMR119W-A_d	YMR119W-A	YMR119W-A	hom	Dubious	0.745698973881967	0.227924639591096	no	1094	0.228122918730546	745	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR052C	YKR052C	MRS4	hom	Verified	0.745575999531819	0.227961792781036	no	1095	0.203117084440069	683	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication	mitochondrial iron ion transport|RNA splicing	iron ion transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YLR380W	YLR380W	CSR1	hom	Verified	0.745003124341171	0.228134915563982	no	1096	0.205743286632793	685	NA	FT	KETONE METABOLISM|LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress	phosphatidylinositol metabolic process|Golgi to plasma membrane protein transport|Golgi to plasma membrane transport|Unknown|negative regulation of fatty acid biosynthetic process|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cytosol|endosome|mitochondrion|lipid particle
YLR176C	YLR176C	RFX1	hom	Verified	0.744281281593311	0.228353161542022	no	1097	0.221939495603067	763	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus|cytoplasm
YBR020W	YBR020W	GAL1	hom	Verified	0.744276683129213	0.228354552243418	no	1098	0.218322542685127	768	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS			Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication	galactose catabolic process via UDP-galactose|carbohydrate phosphorylation|positive regulation of transcription by galactose	galactokinase activity	cytoplasm
YJR078W	YJR078W	BNA2	hom	Verified	0.743558888727599	0.228571691264903	no	1099	0.203869161361623	688	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp	de novo NAD biosynthetic process from tryptophan	tryptophan 2,3-dioxygenase activity|indoleamine 2,3-dioxygenase activity	cytoplasm
YIL024C_p	YIL024C	YIL024C	hom	Uncharacterized	0.742905522933149	0.228769440858329	no	1100	0.219551577382424	742	NA					Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p	biological_process	molecular_function	cellular_component
YNL335W_p	YNL335W	DDI3	hom	Uncharacterized	0.742866303426055	0.228781314203423	no	1101	0.229429896807454	802	NA					Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants	biological_process	molecular_function	cellular_component
YKR012C_d	YKR012C	YKR012C	hom	Dubious	0.742722230994058	0.228824933776692	no	1102	0.190757507429467	664	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2	Unknown	Unknown	Unknown
YLR089C	YLR089C	ALT1	hom	Verified	0.74164885513181	0.229150057477364	no	1103	0.225543720180176	770	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive	alanine catabolic process|alanine biosynthetic process	L-alanine:2-oxoglutarate aminotransferase activity	mitochondrion
YLL038C	YLL038C	ENT4	hom	Verified	0.741354711820951	0.22923919818609	no	1104	0.174120023006412	556	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome	endocytosis|actin filament organization|establishment of protein localization to plasma membrane|actin cortical patch assembly	clathrin binding	actin cortical patch
YPR164W	YPR164W	MMS1	hom	Verified	0.740958650691076	0.229359256001096	no	1105	0.232572190242642	822	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay	replication fork processing|negative regulation of transposition, RNA-mediated|recombinational repair|nonfunctional rRNA decay	molecular_function	Cul8-RING ubiquitin ligase complex
YOL071W	YOL071W	EMI5	hom	Verified	0.740594866088889	0.229469560895813	no	1106	0.190212675206734	625	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)	protein-FAD linkage|cellular respiration|mitochondrial electron transport, succinate to ubiquinone|ascospore formation|tricarboxylic acid cycle|positive regulation of transcription from RNA polymerase II promoter	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial matrix
YKL062W	YKL062W	MSN4	hom	Verified	0.738860415447374	0.229995880651133	no	1107	0.227030624046292	754	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cellular response to acidity|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|replicative cell aging|age-dependent response to oxidative stress involved in chronological cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YNL292W	YNL292W	PUS4	hom	Verified	0.738631688537525	0.230065338311227	no	1108	0.234089254112199	817	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)	tRNA modification	pseudouridine synthase activity	mitochondrion|nucleus
YOR053W_d	YOR053W	YOR053W	hom	Dubious	0.73732617787528	0.23046200824619	no	1109	0.21790010935996	773	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C	Unknown	Unknown	Unknown
YKL147C_d	YKL147C	YKL147C	hom	Dubious	0.736506437876867	0.230711275554119	no	1110	0.180610438485766	601	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3	Unknown	Unknown	Unknown
YJR108W	YJR108W	ABM1	hom	Verified	0.736121313271704	0.23082843658654	no	1111	0.215239032649084	738	NA	FT	CYTOSKELETON ORGANIZATION			Protein of unknown function, required for normal microtubule organization	microtubule cytoskeleton organization	molecular_function	cellular_component
YNL316C	YNL316C	PHA2	hom	Verified	0.73609240214956	0.230837233150483	no	1112	0.209629077270787	724	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway	L-phenylalanine biosynthetic process	prephenate dehydratase activity	cytoplasm
YBR210W	YBR210W	ERV15	hom	Verified	0.734093862858132	0.23144576683771	no	1113	0.211256764584201	679	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION			Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|axial cellular bud site selection	molecular_function	integral to membrane|ER to Golgi transport vesicle
YCR053W	YCR053W	THR4	hom	Verified	0.733885760316961	0.231509183198757	no	1114	0.205576746061444	672	NA	FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|AMINO ACID METABOLISM	NUCLEUS		Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway	endocytosis|threonine metabolic process	threonine synthase activity	nucleus|cytoplasm
YIL055C_p	YIL055C	YIL055C	hom	Uncharacterized	0.733878114057123	0.231511513474805	no	1115	0.230956763549744	764	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YIL012W_d	YIL012W	YIL012W	hom	Dubious	0.732416449451083	0.231957210837899	no	1116	0.234017878446767	801	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER069W	YER069W	ARG5,6	hom	Verified	0.732412824609114	0.231958316734666	no	1117	0.216928910500031	694	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine	ornithine biosynthetic process|arginine biosynthetic process|regulation of transcription, DNA-dependent	N-acetyl-gamma-glutamyl-phosphate reductase activity|acetylglutamate kinase activity	mitochondrion|mitochondrial matrix
YJR098C_p	YJR098C	YJR098C	hom	Uncharacterized	0.73217452074186	0.232031026890265	no	1118	0.207753290019336	716	NA	FT	LIPID METABOLISM	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YHL014C	YHL014C	YLF2	hom	Verified	0.730617863187609	0.232506298967014	no	1119	0.231889921531091	790	NA	FT		MITOCHONDRION		Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	GTP binding	mitochondrion
YPL069C	YPL069C	BTS1	hom	Verified	0.728599926432556	0.233123211762609	no	1120	0.328553418209944	1131	NA	FF|FT	PROTEIN LOCALIZATION|LIPID METABOLISM	MITOCHONDRION		Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic	terpenoid biosynthetic process	farnesyltranstransferase activity	mitochondrion
YOR131C	YOR131C	YOR131C	hom	Verified	0.726807228058268	0.233672027301897	no	1121	0.247851289328928	837	NA	FT		NUCLEUS		Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YPL277C_p	YPL277C	YPL277C	hom	Uncharacterized	0.721267207525913	0.235372564362118	no	1122	0.219888932615573	752	NA					Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels	biological_process	molecular_function	membrane
YOR012W_p	YOR012W	YOR012W	hom	Uncharacterized	0.720857782096102	0.235498510040351	no	1123	0.185130948943503	622	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR118W	YBR118W	TEF2	hom	Verified	0.720293286420604	0.235672218718563	no	1124	0.215228073529365	716	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION	CYTOSKELETON	RIBOSOME	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication	translational elongation|tRNA export from nucleus	GDP binding|GTP binding|translation elongation factor activity	ribosome|eukaryotic translation elongation factor 1 complex|cytoplasm
YOR152C_p	YOR152C	YOR152C	hom	Uncharacterized	0.719054730027997	0.236053599338078	no	1125	0.198396587270372	672	NA					Putative protein of unknown function; YOR152C is not an essential gene	biological_process	molecular_function	membrane
YDR018C_p	YDR018C	YDR018C	hom	Uncharacterized	0.718583023569764	0.236198938208776	no	1126	0.229473585533844	791	NA	FT	LIPID METABOLISM			Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication	phospholipid biosynthetic process	transferase activity, transferring acyl groups	integral to membrane
YDL101C	YDL101C	DUN1	hom	Verified	0.718264887459104	0.236296987888578	no	1127	0.248375593917795	864	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair	protein phosphorylation|replication fork protection|cell cycle checkpoint|DNA damage checkpoint	protein kinase activity	nucleus
YDR090C_p	YDR090C	YDR090C	hom	Uncharacterized	0.71759098474445	0.236504758981133	no	1128	0.258455607760694	880	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YPL014W_p	YPL014W	YPL014W	hom	Uncharacterized	0.716186748917115	0.236938022071216	no	1129	0.241948996059118	840	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YOR378W_p	YOR378W	YOR378W	hom	Uncharacterized	0.715230316504914	0.237233369450694	no	1130	0.217432132847046	730	NA	FT		PLASMA MEMBRANE		Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene	biological_process	molecular_function	integral to membrane
YDR234W	YDR234W	LYS4	hom	Verified	0.714809372952069	0.237363421340081	no	1131	0.248399722499659	856	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway	lysine biosynthetic process via aminoadipic acid	homoaconitate hydratase activity	mitochondrion
YDR459C	YDR459C	PFA5	hom	Verified	0.714571007664986	0.237437082433003	no	1132	0.212917243946475	737	NA	FT		PLASMA MEMBRANE		Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain	protein palmitoylation	palmitoyltransferase activity	integral to membrane|plasma membrane
YPR029C	YPR029C	APL4	hom	Verified	0.714372069956549	0.2374985689816	no	1133	0.216218481850155	740	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YDR476C_p	YDR476C	YDR476C	hom	Uncharacterized	0.713511667587529	0.237764597923358	no	1134	0.225481824923545	767	NA	FT		ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YER042W	YER042W	MXR1	hom	Verified	0.713469804218653	0.23777754588204	no	1135	0.255143105331862	866	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan	cellular response to oxidative stress	peptide-methionine-(S)-S-oxide reductase activity	nucleus|cytoplasm
YDR127W	YDR127W	ARO1	hom	Verified	0.713087541094178	0.237895794271842	no	1136	0.345102899817903	1158	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids	aromatic amino acid family biosynthetic process	shikimate kinase activity|shikimate 3-dehydrogenase (NADP+) activity|3-phosphoshikimate 1-carboxyvinyltransferase activity|3-dehydroquinate dehydratase activity|3-dehydroquinate synthase activity	cytoplasm
YBR147W	YBR147W	RTC2	hom	Verified	0.711776025608142	0.238301740421972	no	1137	0.216040279843811	723	NA	FT		MITOCHONDRION		Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter	biological_process	molecular_function	mitochondrion|integral to membrane
YDR453C	YDR453C	TSA2	hom	Verified	0.710072324349492	0.238829643757355	no	1138	0.221111063696604	728	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress|cell redox homeostasis	peroxiredoxin activity|thioredoxin peroxidase activity	cytoplasm
YIL007C	YIL007C	NAS2	hom	Verified	0.709249394140878	0.239084863160854	no	1139	0.210359639666534	727	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress	proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|cytoplasm
YNL299W	YNL299W	TRF5	hom	Verified	0.708921671371825	0.239186542929633	no	1140	0.251593974660138	887	NA	FT	CELL CYCLE|RNA PROCESSING|CELL DIVISION	NUCLEUS		Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p	nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation	polynucleotide adenylyltransferase activity	nucleolus|TRAMP complex
YHR132W-A	YHR132W-A	IGO2	hom	Verified	0.70767872180719	0.239572397047733	no	1141	0.246065909587048	827	NA	FT		NUCLEUS		Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p	mRNA stabilization	molecular_function	nucleus|cytoplasm
YJR005C-A_p	YJR005C-A	YJR005C-A	hom	Uncharacterized	0.707294319955684	0.239691797306574	no	1142	0.227804359789992	757	NA					Putative protein of unknown function; originally identified as a syntenic homolog of an <i>Ashbya gossypii</i> gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YNL094W	YNL094W	APP1	hom	Verified	0.706870381993675	0.239823515648035	no	1143	0.263289811775616	926	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway	actin cytoskeleton organization	molecular_function	actin cytoskeleton|actin cortical patch
YIL120W	YIL120W	QDR1	hom	Verified	0.706832129875848	0.239835402596666	no	1144	0.223582010488096	761	NA	FT		PLASMA MEMBRANE		Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication	drug transmembrane transport	drug transmembrane transporter activity	integral to membrane|plasma membrane
YNL119W	YNL119W	NCS2	hom	Verified	0.706817644106928	0.239839904172271	no	1145	0.229279607671273	799	NA	FT	RNA PROCESSING			Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	tRNA wobble position uridine thiolation|pseudohyphal growth|protein urmylation|invasive growth in response to glucose limitation	molecular_function	cytosol|cytoplasm
YFL041W	YFL041W	FET5	hom	Verified	0.70661624514262	0.239902495384208	no	1146	0.214463343998007	739	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS	PLASMA MEMBRANE		Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport	iron ion transport	ferroxidase activity	fungal-type vacuole membrane|integral to membrane
YLR399C	YLR399C	BDF1	hom	Verified	0.70643144233429	0.239959936643659	no	1147	0.212769295967194	759	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p	DNA repair|snRNA transcription|regulation of chromatin silencing at telomere|regulation of transcription by chromatin organization|regulation of chromatin silencing at silent mating-type cassette|Unknown|chromatin remodeling|negative regulation of heterochromatin assembly	histone acetyl-lysine binding|chromatin binding|core promoter binding|TFIID-class transcription factor binding	nuclear chromatin|Swr1 complex
YLR287C_p	YLR287C	YLR287C	hom	Uncharacterized	0.705908162815453	0.240122625470776	no	1148	0.225983279559837	751	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene	biological_process	molecular_function	cytoplasm
YDR089W	YDR089W	YDR089W	hom	Verified	0.70504331343883	0.240391640918193	no	1149	0.209123389291938	708	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress	cellular membrane organization	molecular_function	integral to membrane|membrane
YGL228W	YGL228W	SHE10	hom	Verified	0.704842016805397	0.240454278722204	no	1150	0.236738311054939	829	NA	FT		MITOCHONDRION		Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest	biological_process	molecular_function	cellular_component
YKL194C	YKL194C	MST1	hom	Verified	0.704786904890456	0.240471429537121	no	1151	0.278298345881365	940	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro	mitochondrial threonyl-tRNA aminoacylation	threonine-tRNA ligase activity	mitochondrion
YML022W	YML022W	APT1	hom	Verified	0.704050249635116	0.240700740432519	no	1152	0.194310254590939	662	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication	AMP biosynthetic process|adenine salvage	adenine phosphoribosyltransferase activity	nucleus|cytoplasm
YML097C	YML097C	VPS9	hom	Verified	0.703757123982019	0.240792019604296	no	1153	0.235405611476017	814	NA	FF|FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT			A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin	vacuole inheritance|protein targeting to vacuole	ubiquitin binding|guanyl-nucleotide exchange factor activity	cytosol
YKL174C	YKL174C	TPO5	hom	Verified	0.703397932079534	0.240903897447243	no	1154	0.22198456436196	733	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles	polyamine transport	polyamine transmembrane transporter activity	integral to membrane|Golgi apparatus
YLR286C	YLR286C	CTS1	hom	Verified	0.703362700747978	0.240914872506077	no	1155	0.226319340601291	796	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p	cytokinesis, completion of separation|chitin catabolic process	endochitinase activity	nuclear envelope|extracellular region|fungal-type cell wall|endoplasmic reticulum|cellular bud neck
YNL042W-B_p	YNL042W-B	YNL042W-B	hom	Uncharacterized	0.702485241350148	0.241188301257165	no	1156	0.213118684688705	754	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YER117W	YER117W	RPL23B	hom	Verified	0.701814256501272	0.241397503379915	no	1157	0.23786890554753	827	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR425W	YDR425W	SNX41	hom	Verified	0.701066079918057	0.241630888817198	no	1158	0.219215069172011	752	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT			Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p	retrograde transport, endosome to Golgi	phosphatidylinositol binding|phosphatidylinositol-3-phosphate binding	endosome
YDL203C	YDL203C	ACK1	hom	Verified	0.699227764393917	0.242204850990512	no	1159	0.240041568511018	792	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria	fungal-type cell wall organization|positive regulation of signal transduction	molecular_function	mitochondrion
YLL041C	YLL041C	SDH2	hom	Verified	0.69879028351879	0.242341550840422	no	1160	0.239071974806684	800	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain	mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial membrane
YJR152W	YJR152W	DAL5	hom	Verified	0.698492948596562	0.242434483077944	no	1161	0.237364966966038	788	NA	FT		PLASMA MEMBRANE		Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression	dipeptide transport|allantoate transport	dipeptide transporter activity|allantoate transmembrane transporter activity	integral to membrane|plasma membrane
YAL048C	YAL048C	GEM1	hom	Verified	0.69740603788518	0.24277436199759	no	1162	0.222814492434615	796	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases	mitochondrion inheritance|regulation of mitochondrion organization|phospholipid homeostasis	GTPase activity|calcium ion binding	mitochondrial outer membrane|ERMES complex|mitochondrion
YNL201C	YNL201C	PSY2	hom	Verified	0.697308669994863	0.242804821692007	no	1163	0.280473182178167	922	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3	Unknown|response to DNA damage stimulus|protein dephosphorylation|signal transduction involved in meiotic recombination checkpoint	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus
YNL191W	YNL191W	DUG3	hom	Verified	0.697131452546336	0.242860266111063	no	1164	0.231970148723823	803	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	peptidase activity|omega peptidase activity|gamma-glutamyltransferase activity|carbon-nitrogen ligase activity, with glutamine as amido-N-donor	cytoplasm
YOR100C	YOR100C	CRC1	hom	Verified	0.696973131029943	0.242909804524457	no	1165	0.219525322028642	757	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation	fatty acid metabolic process	carnitine:acyl carnitine antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YAL004W_d	YAL004W	YAL004W	hom	Dubious	0.696961998927875	0.242913287937547	no	1166	0.263446041141474	886	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C	Unknown	Unknown	Unknown
YJL152W_d	YJL152W	YJL152W	hom	Dubious	0.696812022298644	0.242960220662408	no	1167	0.168171019698577	570	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR269C_d	YLR269C	YLR269C	hom	Dubious	0.696590492613173	0.243029553715242	no	1168	0.231363404478768	782	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR167C	YPR167C	MET16	hom	Verified	0.695728504373226	0.243299435507043	no	1169	0.239670720350575	817	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process	phosphoadenylyl-sulfate reductase (thioredoxin) activity	cytoplasm
YMR312W	YMR312W	ELP6	hom	Verified	0.69562402184163	0.243332159175781	no	1170	0.249300174698784	851	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	protein urmylation|regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex
YBR264C	YBR264C	YPT10	hom	Verified	0.695268940075114	0.243443387676601	no	1171	0.242705675535791	821	NA	FT	PROTEIN LOCALIZATION|SIGNALING	PLASMA MEMBRANE		Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles	Golgi organization	GTPase activity|guanyl nucleotide binding	cytoplasm
YJL095W	YJL095W	BCK1	hom	Verified	0.695181020802821	0.243470932417187	no	1172	0.322049323772282	1116	NA	FF|FT	SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH		Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p	intracellular protein kinase cascade|endoplasmic reticulum unfolded protein response|peroxisome degradation|establishment of cell polarity|protein phosphorylation|response to acid|response to nutrient	protein kinase activity|MAP kinase kinase kinase activity	intracellular|mating projection tip
YLR381W	YLR381W	CTF3	hom	Verified	0.694889726744331	0.243562205657354	no	1173	0.216927750387895	751	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6	chromosome segregation|DNA replication initiation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YNR032W	YNR032W	PPG1	hom	Verified	0.693409994116045	0.244026146058898	no	1174	0.242977795313115	799	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases	glycogen metabolic process|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YJL098W	YJL098W	SAP185	hom	Verified	0.693361244762884	0.24404143854475	no	1175	0.243620191855622	829	NA	FT	CELL CYCLE|RNA PROCESSING	MITOCHONDRION		Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication	tRNA wobble uridine modification|G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	mitochondrion|cytoplasm
YBR175W	YBR175W	SWD3	hom	Verified	0.693271238745576	0.244069674446732	no	1176	0.239805678344656	815	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5	histone H3-K4 methylation|telomere maintenance|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YLR068W	YLR068W	FYV7	hom	Verified	0.692279885107914	0.244380789806733	no	1177	0.25161615960133	873	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|nucleus
YEL054C	YEL054C	RPL12A	hom	Verified	0.690017767377748	0.245091507082528	no	1178	0.235750678309584	801	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR351C	YLR351C	NIT3	hom	Verified	0.690000349276333	0.245096983850786	no	1179	0.227125568540469	765	NA	FT		MITOCHONDRION		Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member	biological_process	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	mitochondrion|cytoplasm
YKR039W	YKR039W	GAP1	hom	Verified	0.689374800325906	0.245293718638754	no	1180	0.243643430805162	790	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	PLASMA MEMBRANE		General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth	amino acid transport|gamma-aminobutyric acid transport|ammonia assimilation cycle|polyamine transport	amino acid transmembrane transporter activity|polyamine transmembrane transporter activity|L-proline transmembrane transporter activity	endosome|fungal-type vacuole lumen|integral to membrane|plasma membrane|ER to Golgi transport vesicle|integral to plasma membrane|multivesicular body
YHL042W_p	YHL042W	YHL042W	hom	Uncharacterized	0.688960141110412	0.245424175496104	no	1181	0.223057215211449	735	NA					Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	cellular_component
YGL210W	YGL210W	YPT32	hom	Verified	0.687821225356417	0.24578268406714	no	1182	0.212618805191298	731	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication	early endosome to Golgi transport|vesicle-mediated transport|exocytosis	GTPase activity	endosome|mitochondrial outer membrane|Golgi apparatus
YOR334W	YOR334W	MRS2	hom	Verified	0.687551851427902	0.245867518843799	no	1183	0.232866168682477	795	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns	mitochondrial magnesium ion transport	magnesium ion transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YOR161C-C_p	YOR161C-C	YOR161C-C	hom	Uncharacterized	0.686041298407684	0.246343533074504	no	1184	0.224490662420578	746	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YMR109W	YMR109W	MYO5	hom	Verified	0.685890637009837	0.246391037445718	no	1185	0.232102019428766	786	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization	bipolar cellular bud site selection|endocytosis|exocytosis|fungal-type cell wall organization|response to salt stress|receptor-mediated endocytosis|actin cortical patch localization|response to osmotic stress	microfilament motor activity	mating projection tip|actin cortical patch
YGR202C	YGR202C	PCT1	hom	Verified	0.684189973753638	0.246927606302094	no	1186	0.216767950559314	727	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity	phosphatidylcholine biosynthetic process|CDP-choline pathway	choline-phosphate cytidylyltransferase activity	nuclear envelope|Golgi apparatus|nucleus
YGL252C	YGL252C	RTG2	hom	Verified	0.684101875635571	0.246955418781373	no	1187	0.26589987443304	927	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|SIGNALING|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p	maintenance of DNA trinucleotide repeats|regulation of transcription from RNA polymerase II promoter|Unknown|nitrogen catabolite regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway|transcription factor import into nucleus	RNA polymerase II transcription factor binding transcription factor activity	SLIK (SAGA-like) complex|transcriptionally active chromatin|cytoplasm
YBR172C	YBR172C	SMY2	hom	Verified	0.683641622780545	0.247100747354541	no	1188	0.220106310726322	718	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport	molecular_function	endoplasmic reticulum membrane|cytoplasmic mRNA processing body|cytoplasm|extrinsic to membrane
YOR135C_d	YOR135C	IRC14	hom	Dubious	0.683111906105916	0.247268066300484	no	1189	0.224223624654183	775	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci	Unknown	Unknown	Unknown
YPL027W	YPL027W	SMA1	hom	Verified	0.682698154491818	0.247398798068363	no	1190	0.218887022271711	707	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p	ascospore-type prospore membrane assembly	molecular_function	prospore membrane
YLR021W	YLR021W	IRC25	hom	Verified	0.682039751463302	0.247606907699228	no	1191	0.254639590858867	859	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions	proteasome assembly|chaperone-mediated protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	intracellular
YBR052C	YBR052C	RFS1	hom	Verified	0.68112745807022	0.24789542209528	no	1192	0.204439099029742	722	NA	FT	OXIDATION-REDUCTION PROCESS			Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication	biological_process	molecular_function	membrane raft|cytoplasm
YLR334C_d	YLR334C	YLR334C	hom	Dubious	0.680863581210384	0.247978907061524	no	1193	0.220845278573181	733	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here	Unknown	Unknown	Unknown
YDR430C	YDR430C	CYM1	hom	Verified	0.680438365203257	0.248113467826465	no	1194	0.218848266226941	659	NA	FT	PROTEOLYSIS	MITOCHONDRION		Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology	proteolysis|proteolysis involved in cellular protein catabolic process	metalloendopeptidase activity	mitochondrion|mitochondrial intermembrane space
YIL145C	YIL145C	PAN6	hom	Verified	0.679630701137685	0.248369162533114	no	1195	0.213418694010328	720	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC	pantothenate biosynthetic process	pantoate-beta-alanine ligase activity	nucleus|cytoplasm
YDR344C_d	YDR344C	YDR344C	hom	Dubious	0.678985547861539	0.248573509551554	no	1196	0.242930163353781	815	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL016C	YEL016C	NPP2	hom	Verified	0.677751949212862	0.248964491057873	no	1197	0.254654829342482	859	NA	FT	NUCLEOTIDE METABOLISM			Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication	nucleoside triphosphate metabolic process	nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity	cellular_component
YGR043C	YGR043C	NQM1	hom	Verified	0.677433866906099	0.249065358335076	no	1198	0.241278774551197	846	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift	biological_process	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	nucleus
YHR079C	YHR079C	IRE1	hom	Verified	0.677157789869771	0.249152922916051	no	1199	0.275820320343948	929	NA	FF|FT	RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress	endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|inositol metabolic process|protein phosphorylation	unfolded protein binding|protein serine/threonine kinase activity|endoribonuclease activity|protein kinase activity|protein homodimerization activity	nucleus
YDR405W	YDR405W	MRP20	hom	Verified	0.677135866581124	0.249159877124674	no	1200	0.235968740442883	833	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGR118W	YGR118W	RPS23A	hom	Verified	0.677064723465107	0.249182444891209	no	1201	0.258227013646724	882	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity	structural constituent of ribosome	cytosolic small ribosomal subunit
YPL092W	YPL092W	SSU1	hom	Verified	0.676773943262191	0.249274696455354	no	1202	0.253565517620563	822	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein	sulfite transport	sulfite transmembrane transporter activity	integral to membrane|plasma membrane
YER078C	YER078C	ICP55	hom	Verified	0.676312863891973	0.249421013553462	no	1203	0.248888228178359	859	NA	FT	PROTEOLYSIS	NUCLEUS|MITOCHONDRION		Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family	protein stabilization|protein processing	aminopeptidase activity	extrinsic to mitochondrial inner membrane|mitochondrion|nucleus
YPL240C	YPL240C	HSP82	hom	Verified	0.674939344394766	0.249857151161569	no	1204	0.266120978820221	958	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION			Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication	proteasome assembly|positive regulation of telomere maintenance via telomerase|box C/D snoRNP assembly|response to stress|protein refolding|protein targeting to mitochondrion|response to osmotic stress|'de novo' protein folding	unfolded protein binding|ATPase activity, coupled	cytoplasm
YAL062W	YAL062W	GDH3	hom	Verified	0.674490759476595	0.249999679274407	no	1205	0.230923635162603	786	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS|MITOCHONDRION		NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication	glutamate biosynthetic process|ammonia assimilation cycle	glutamate dehydrogenase (NADP+) activity	mitochondrion|nucleus
YLR307W	YLR307W	CDA1	hom	Verified	0.672707163127422	0.250566804785917	no	1206	0.219943369125232	747	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall	ascospore wall assembly	chitin deacetylase activity	chitosan layer of spore wall
YGL045W	YGL045W	RIM8	hom	Verified	0.672151905130297	0.250743497754574	no	1207	0.283868799680226	965	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family	meiosis|protein processing|invasive growth in response to glucose limitation|ubiquitin-dependent endocytosis	molecular_function	internal side of plasma membrane
YLR183C	YLR183C	TOS4	hom	Verified	0.670566807456271	0.251248266818263	no	1208	0.253577447004566	869	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication	response to DNA damage stimulus	chromatin binding	nuclear chromatin|Rpd3L-Expanded complex|mitochondrion|nucleus|cytoplasm
YAR020C	YAR020C	PAU7	hom	Verified	0.670203954293662	0.251363891729255	no	1209	0.253272594812925	851	NA					Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YBL032W	YBL032W	HEK2	hom	Verified	0.669673216021526	0.251533064686958	no	1210	0.244352617822383	849	NA	FT	CHROMATIN ORGANIZATION|TRANSLATION|RNA LOCALIZATION	NUCLEUS|CHROMOSOME		RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K	telomere maintenance via telomerase|intracellular mRNA localization|mRNA stabilization	mRNA binding	nuclear chromosome, telomeric region|cytoplasmic mRNA processing body|cytoplasm
YKL161C	YKL161C	KDX1	hom	Verified	0.668913263683379	0.251775404384664	no	1211	0.273958886099574	948	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p	biological_process	protein kinase activity	cellular_component
YFR026C	YFR026C	ULI1	hom	Verified	0.66731523729104	0.252285397753872	no	1212	0.253199991737155	881	NA	FT	SIGNALING			Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response	endoplasmic reticulum unfolded protein response	molecular_function	cellular_component
YCR047C	YCR047C	BUD23	hom	Verified	0.667167974259335	0.252332422600102	no	1213	0.23789113950556	831	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION	NUCLEUS		Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA (guanine-N7)-methylation|cellular bud site selection|ribosomal small subunit export from nucleus	S-adenosylmethionine-dependent methyltransferase activity|rRNA (guanine) methyltransferase activity	nucleolus|nucleus|cytoplasm
YNL157W	YNL157W	IGO1	hom	Verified	0.667046026055854	0.252371367272584	no	1214	0.192867399786438	644	NA	FT		NUCLEUS		Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p	mRNA stabilization	molecular_function	nucleus|cytoplasmic mRNA processing body|cytoplasm
YBL081W_p	YBL081W	YBL081W	hom	Uncharacterized	0.666949190434138	0.252402294392971	no	1215	0.231165827592038	778	NA					Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport	biological_process	molecular_function	cellular_component
YGR135W	YGR135W	PRE9	hom	Verified	0.665868500547293	0.252747577943607	no	1216	0.256178972301404	864	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform	proteasomal ubiquitin-dependent protein catabolic process|proteasome core complex assembly|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YDR312W	YDR312W	SSF2	hom	Verified	0.665652234903006	0.252816705297973	no	1217	0.215778653710829	720	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication	conjugation with cellular fusion|ribosomal large subunit assembly	rRNA binding	nucleolus
YPL067C_p	YPL067C	YPL067C	hom	Uncharacterized	0.664355094543712	0.25323153326107	no	1218	0.239818985600017	795	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene	biological_process	molecular_function	cytoplasm
YMR006C	YMR006C	PLB2	hom	Verified	0.663283990563585	0.253574343961219	no	1219	0.213455285821775	741	NA	FT	LIPID METABOLISM			Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine	glycerophospholipid metabolic process	lysophospholipase activity	extracellular region|fungal-type cell wall
YGR121C	YGR121C	MEP1	hom	Verified	0.662883249563638	0.253702665207025	no	1220	0.238545393674535	786	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation	nitrogen utilization|ammonium transport	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YJR094C	YJR094C	IME1	hom	Verified	0.662790820119515	0.253732266871335	no	1221	0.220500646653136	746	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p	pseudohyphal growth|regulation of transcription from RNA polymerase II promoter|regulation of meiosis	protein binding transcription factor activity	nucleus
YPR124W	YPR124W	CTR1	hom	Verified	0.661614387142271	0.254109192361432	no	1222	0.356848138881134	1190	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress	copper ion import	copper uptake transmembrane transporter activity	integral to membrane|plasma membrane
YFL027C	YFL027C	GYP8	hom	Verified	0.660021251355752	0.254620095928314	no	1223	0.24008193742493	828	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM			GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport	vesicle-mediated transport	Rab GTPase activator activity	intracellular
YDR520C_p	YDR520C	URC2	hom	Uncharacterized	0.659973954642351	0.25463527175569	no	1224	0.290300972150988	981	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism	uracil catabolic process	sequence-specific DNA binding	nucleus|cytoplasm
YAL027W	YAL027W	SAW1	hom	Verified	0.65920858624707	0.254880917003081	no	1225	0.210332509064743	708	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		5'- and 3'-flap DNA binding protein; stimulates the endonuclease activity of Rad1/Rad10p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	double-strand break repair via single-strand annealing, removal of nonhomologous ends	molecular_function	nucleus
YPL150W_p	YPL150W	YPL150W	hom	Uncharacterized	0.658813377029876	0.255007808074698	no	1226	0.225018411877799	751	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study	protein phosphorylation	protein kinase activity	cellular_component
YBR300C_d	YBR300C	YBR300C	hom	Dubious	0.657212963830555	0.255521995512783	no	1227	0.262252140608952	928	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene	Unknown	Unknown	Unknown
YNL054W	YNL054W	VAC7	hom	Verified	0.656770517191697	0.255664242124802	no	1228	0.204080806249513	713	NA	FT	LIPID METABOLISM			Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock	positive regulation of phosphatidylinositol biosynthetic process|positive regulation of kinase activity	molecular_function	fungal-type vacuole membrane|integral to membrane|PAS complex|vacuolar membrane|cytoplasm
YMR037C	YMR037C	MSN2	hom	Verified	0.65399242187026	0.25655834396486	no	1229	0.250708503900761	861	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|cellular response to methylmercury|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YER057C	YER057C	HMF1	hom	Verified	0.653888834048375	0.256591714124198	no	1230	0.226546861357387	761	NA	FT		NUCLEUS		Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro	biological_process	molecular_function	cytosol|nucleus|cytoplasm
YDR491C_d	YDR491C	YDR491C	hom	Dubious	0.652559715531675	0.257020081713333	no	1231	0.226991803216195	776	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL159C	YOL159C	YOL159C	hom	Verified	0.650394383693862	0.257718752101807	no	1232	0.23430385264622	798	NA					Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA	biological_process	molecular_function	cellular_component
YDR104C	YDR104C	SPO71	hom	Verified	0.6495599535937	0.257988253955129	no	1233	0.222978284972701	739	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains	ascospore wall assembly	molecular_function	ascospore wall
YGL087C	YGL087C	MMS2	hom	Verified	0.649125678719799	0.25812857263203	no	1234	0.251404344867986	839	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress	postreplication repair|response to DNA damage stimulus|protein polyubiquitination|free ubiquitin chain polymerization	ubiquitin-protein ligase activity	ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YLR070C	YLR070C	XYL2	hom	Verified	0.648437063742627	0.258351152305911	no	1235	0.264399799821811	893	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM			Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect	xylulose biosynthetic process	D-xylulose reductase activity	cellular_component
YJL164C	YJL164C	TPK1	hom	Verified	0.648036477279853	0.258480678824624	no	1236	0.252796901228187	866	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication	protein phosphorylation|Ras protein signal transduction	cAMP-dependent protein kinase activity|protein kinase activity	cAMP-dependent protein kinase complex|nucleus|cytoplasm
YLR271W_p	YLR271W	YLR271W	hom	Uncharacterized	0.64715379015973	0.258766207516163	no	1237	0.237841720113577	808	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YDR015C_d	YDR015C	YDR015C	hom	Dubious	0.645870090800145	0.259181745445213	no	1238	0.246338916943557	832	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A	Unknown	Unknown	Unknown
YFR007W	YFR007W	YFH7	hom	Verified	0.64585201813746	0.259187598090025	no	1239	0.246131024078007	856	NA					Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases	phosphorylation	ATPase activity|kinase activity	cellular_component
YKR061W	YKR061W	KTR2	hom	Verified	0.645465280014891	0.259312855599706	no	1240	0.243460033007989	840	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication	cell wall mannoprotein biosynthetic process|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YOL129W	YOL129W	VPS68	hom	Verified	0.644462286855822	0.259637852702826	no	1241	0.270251404988704	950	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	MITOCHONDRION		Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria	late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole	molecular_function	Vps55/Vps68 complex|mitochondrion|fungal-type vacuole membrane|integral to membrane
YDL180W_p	YDL180W	YDL180W	hom	Uncharacterized	0.643809574621224	0.259849462131478	no	1242	0.264231657370565	919	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YDR244W	YDR244W	PEX5	hom	Verified	0.64373995861857	0.259872036902487	no	1243	0.28009512680186	941	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions	protein import into peroxisome matrix, docking	peroxisome matrix targeting signal-1 binding|protein binding, bridging	cytosol|peroxisomal membrane|peroxisome
YER140W	YER140W	EMP65	hom	Verified	0.642971187069528	0.260121398017216	no	1244	0.252625136143295	879	NA	FT		MITOCHONDRION		ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	protein folding in endoplasmic reticulum	molecular_function	mitochondrion|integral to membrane
YOL055C	YOL055C	THI20	hom	Verified	0.642939016893899	0.260131835522912	no	1245	0.241643482791397	828	NA					Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p	thiamine biosynthetic process|thiamine catabolic process	phosphomethylpyrimidine kinase activity|thiaminase activity|hydroxymethylpyrimidine kinase activity	cytosol
YML095C	YML095C	RAD10	hom	Verified	0.64270520389332	0.26020770185365	no	1246	0.24555667368222	822	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein	mitotic recombination|meiotic mismatch repair|DNA strand renaturation|nucleotide-excision repair, DNA incision, 5'-to lesion|removal of nonhomologous ends|double-strand break repair via single-strand annealing, removal of nonhomologous ends	single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity	nucleotide-excision repair factor 1 complex|nucleus
YIL089W	YIL089W	YIL089W	hom	Verified	0.642092843900322	0.260406451015834	no	1247	0.229936853913908	774	NA	FT		ENDOPLASMIC RETICULUM		Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking	biological_process	molecular_function	fungal-type vacuole lumen|integral to membrane|endoplasmic reticulum
YDR332W	YDR332W	IRC3	hom	Verified	0.640862487455255	0.260806014967243	no	1248	0.26111411848469	898	NA	FT		MITOCHONDRION		Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	ATP-dependent RNA helicase activity	mitochondrion
YPR155C	YPR155C	NCA2	hom	Verified	0.640322904512855	0.260981346467786	no	1249	0.242439183993856	846	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p	mRNA metabolic process|aerobic respiration	molecular_function	mitochondrial outer membrane|mitochondrion
YER038W-A_d	YER038W-A	YER038W-A	hom	Dubious	0.639730546768145	0.261173896322218	no	1250	0.268868955485702	887	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria	Unknown	Unknown	Unknown
YDL234C	YDL234C	GYP7	hom	Verified	0.639429209831538	0.261271875921227	no	1251	0.229876847594427	793	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM			GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking	regulation of vacuole fusion, non-autophagic|vesicle-mediated transport	Rab GTPase activator activity	cytoplasm
YNL083W	YNL083W	SAL1	hom	Verified	0.639277523209228	0.261321203917712	no	1252	0.25033201995725	859	NA	FT		MITOCHONDRION		ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains	ATP transport|ADP transport|mitochondrial transport	ATP:ADP antiporter activity|calcium ion binding	mitochondrion|integral to membrane|mitochondrial inner membrane
YOL057W	YOL057W	YOL057W	hom	Verified	0.638052775387726	0.261719663108174	no	1253	0.248608041455269	823	NA	FT	PROTEOLYSIS	NUCLEUS		Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers	proteolysis	dipeptidyl-peptidase activity	nucleus|cytoplasm
YEL001C	YEL001C	IRC22	hom	Verified	0.637889093719231	0.261772938871465	no	1254	0.235474165375826	806	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	endoplasmic reticulum
YLL002W	YLL002W	RTT109	hom	Verified	0.637300654897619	0.261964512230502	no	1255	0.267420167916088	927	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS		Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p	negative regulation of transposition, RNA-mediated|histone acetylation|double-strand break repair via nonhomologous end joining|response to DNA damage stimulus|regulation of transcription from RNA polymerase II promoter in response to stress	H3 histone acetyltransferase activity	nucleus
YFL049W	YFL049W	SWP82	hom	Verified	0.637292455110402	0.261967182277894	no	1256	0.248163891052781	837	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	RSC COMPLEX	Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex|nucleus
YCL033C	YCL033C	MXR2	hom	Verified	0.637207833747348	0.261994737838344	no	1257	0.252577394911973	853	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan	cellular response to oxidative stress	peptide-methionine (R)-S-oxide reductase activity	mitochondrion
YDR156W	YDR156W	RPA14	hom	Verified	0.636418165801876	0.262251951880705	no	1258	0.224941066434317	764	NA	FT		NUCLEUS		RNA polymerase I subunit A14	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size	molecular_function	DNA-directed RNA polymerase I complex
YDL010W	YDL010W	GRX6	hom	Verified	0.634989554671568	0.262717613732554	no	1259	0.258632764137612	849	NA	FT	RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication	cellular response to oxidative stress	glutathione-disulfide reductase activity|iron ion binding|protein homodimerization activity|2 iron, 2 sulfur cluster binding	integral to membrane|Golgi apparatus|Golgi lumen|endoplasmic reticulum membrane|fungal-type vacuole|cis-Golgi network
YGL141W	YGL141W	HUL5	hom	Verified	0.634771477847242	0.262788733991809	no	1260	0.275154440365942	939	NA	FT	PROTEOLYSIS	NUCLEUS		Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD	ER-associated protein catabolic process|protein polyubiquitination	ubiquitin-ubiquitin ligase activity	proteasome complex|nucleus|cytoplasm
YGR124W	YGR124W	ASN2	hom	Verified	0.633876469256311	0.263080721584965	no	1261	0.256360698180352	881	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication	asparagine biosynthetic process	asparagine synthase (glutamine-hydrolyzing) activity	cytoplasm
YLR377C	YLR377C	FBP1	hom	Verified	0.633528007645252	0.263194448520143	no	1262	0.26698738947378	919	NA	FT	CARBOHYDRATE METABOLISM			Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p	gluconeogenesis|reactive oxygen species metabolic process	fructose 1,6-bisphosphate 1-phosphatase activity	cytosol
YLL054C_p	YLL054C	YLL054C	hom	Uncharacterized	0.633188684048147	0.263305217224483	no	1263	0.26777321582081	894	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene	biological_process	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	cellular_component
YGR148C	YGR148C	RPL24B	hom	Verified	0.633028830050756	0.263357408168802	no	1264	0.266085553640055	886	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YDL089W	YDL089W	NUR1	hom	Verified	0.632356380050647	0.263577015094886	no	1265	0.273736178399262	938	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate	maintenance of rDNA	molecular_function	nuclear periphery
YDR218C	YDR218C	SPR28	hom	Verified	0.632323109917656	0.263587882791521	no	1266	0.246053480876975	847	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation	sexual sporulation resulting in formation of a cellular spore	structural molecule activity	spindle microtubule|meiotic spindle|septin complex|prospore membrane|ascospore wall
YOR066W	YOR066W	MSA1	hom	Verified	0.632294159897909	0.263597339508193	no	1267	0.259782356984381	902	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation	G1/S transition of mitotic cell cycle|regulation of transcription involved in G1 phase of mitotic cell cycle|regulation of cell size	molecular_function	nucleus|cytoplasm
YOR137C	YOR137C	SIA1	hom	Verified	0.631763163338603	0.263770823770266	no	1268	0.241873970717564	856	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose	proton transport	molecular_function	cellular_component
YGL198W	YGL198W	YIP4	hom	Verified	0.63136435783024	0.263901157579315	no	1269	0.276577664328687	923	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YML116W	YML116W	ATR1	hom	Verified	0.63103157492432	0.264009939632759	no	1270	0.219111568682798	705	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	borate transport|drug transmembrane transport	drug transmembrane transporter activity|borate transmembrane transporter activity	integral to membrane|plasma membrane|vacuole
YBR222C	YBR222C	PCS60	hom	Verified	0.630516885596031	0.264178229327521	no	1271	0.232056943421195	796	NA					Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase	biological_process	mRNA binding|AMP binding	integral to membrane|peroxisomal matrix|peroxisomal membrane|cytoplasm
YLR448W	YLR448W	RPL6B	hom	Verified	0.630113685009097	0.264310103332065	no	1272	0.272593983181917	942	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YJL169W_d	YJL169W	YJL169W	hom	Dubious	0.628402992723647	0.264869988540336	no	1273	0.248233700682487	854	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2	Unknown	Unknown	Unknown
YMR160W	YMR160W	YMR160W	hom	Verified	0.627826321419138	0.265058860606732	no	1274	0.259508910843878	915	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress	biological_process	molecular_function	fungal-type vacuole membrane
YDR109C_p	YDR109C	YDR109C	hom	Uncharacterized	0.627642143885606	0.265119197061702	no	1275	0.25053362115126	855	NA	FT	CARBOHYDRATE METABOLISM			Putative kinase	biological_process	molecular_function	cellular_component
YBL065W_d	YBL065W	YBL065W	hom	Dubious	0.627547174392525	0.265150311739198	no	1276	0.28097974638766	921	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene	Unknown	Unknown	Unknown
YDR097C	YDR097C	MSH6	hom	Verified	0.626634719787098	0.26544935201157	no	1277	0.23968393574992	794	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p	mismatch repair|meiotic mismatch repair	guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity|single base insertion or deletion binding|ATP binding	MutSalpha complex|nucleus
YLR059C	YLR059C	REX2	hom	Verified	0.626457845004273	0.265507339274661	no	1278	0.274080942569579	946	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease	U5 snRNA 3'-end processing|U4 snRNA 3'-end processing|mitochondrial genome maintenance|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3'-5'-exoribonuclease activity|3'-5' exonuclease activity	mitochondrion
YML086C	YML086C	ALO1	hom	Verified	0.626078138923534	0.265631845179843	no	1279	0.24279002920902	824	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress	cellular response to oxidative stress|dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinono-1,4-lactone oxidase activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YKL105C	YKL105C	SEG2	hom	Verified	0.625800164549806	0.265723011951298	no	1280	0.25066054049573	850	NA					Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes	biological_process	molecular_function	cellular_component
YOL083W	YOL083W	ATG34	hom	Verified	0.625450101917431	0.265837843946412	no	1281	0.248792724531395	806	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS			Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog	protein complex assembly|protein complex localization	protein binding, bridging	CVT complex
YOR276W	YOR276W	CAF20	hom	Verified	0.625141928091847	0.265938955854441	no	1282	0.250896441248346	842	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E	negative regulation of translation|positive regulation of cytoplasmic mRNA processing body assembly	translation regulator activity	mRNA cap binding complex
YLR414C	YLR414C	PUN1	hom	Verified	0.624970136303052	0.265995329239873	no	1283	0.227399469696496	749	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress	fungal-type cell wall organization|protein oligomerization	molecular_function	integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YNL298W	YNL298W	CLA4	hom	Verified	0.624479040517354	0.266156515444414	no	1284	0.331987304078853	1103	NA	FF|FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p	negative regulation of gene expression|vacuole inheritance|protein phosphorylation|budding cell apical bud growth|Rho protein signal transduction|regulation of exit from mitosis|establishment of cell polarity|sterol import|response to pheromone|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	nucleus|cellular bud|fungal-type vacuole
YLL062C	YLL062C	MHT1	hom	Verified	0.623377649386424	0.266518190969512	no	1285	0.263147539280646	903	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio	sulfur amino acid metabolic process	homocysteine S-methyltransferase activity	cytoplasm
YEL042W	YEL042W	GDA1	hom	Verified	0.622894640609034	0.266676880072251	no	1286	0.263150131056432	894	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate	protein glycosylation	guanosine-diphosphatase activity|uridine-diphosphatase activity	Golgi apparatus
YDL171C	YDL171C	GLT1	hom	Verified	0.622855774662398	0.266689651278997	no	1287	0.251639665708983	861	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source	glutamate biosynthetic process|ammonia assimilation cycle	glutamate synthase (NADH) activity	mitochondrion
YEL017C-A	YEL017C-A	PMP2	hom	Verified	0.622326592822888	0.266863569237191	no	1288	0.280942963504219	964	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication	cation transport	molecular_function	membrane
YNL231C	YNL231C	PDR16	hom	Verified	0.622304376227005	0.26687087207313	no	1289	0.285002877873356	999	NA	FF|FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress	response to drug|sterol biosynthetic process|phospholipid biosynthetic process|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cell periphery|lipid particle|plasma membrane|cytoplasm
YOL158C	YOL158C	ENB1	hom	Verified	0.621196092366463	0.26723530509634	no	1290	0.250475243456822	849	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment	ferric-enterobactin transport	ferric-enterobactin transmembrane transporter activity	integral to membrane|cellular bud membrane|plasma membrane
YGL223C	YGL223C	COG1	hom	Verified	0.620930335483905	0.267322730300888	no	1291	0.32325607745305	1077	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YMR031C	YMR031C	EIS1	hom	Verified	0.620704554157322	0.267397016208499	no	1292	0.278113794079348	921	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress	eisosome assembly	molecular_function	eisosome|mitochondrion|membrane raft|cytoplasm
YKL023W_p	YKL023W	YKL023W	hom	Uncharacterized	0.620395816808534	0.267498612914108	no	1293	0.260138485447415	913	NA					Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YJR135C	YJR135C	MCM22	hom	Verified	0.619806477043876	0.267692601943712	no	1294	0.254455876056454	865	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YMR096W	YMR096W	SNZ1	hom	Verified	0.619788727610925	0.267698445505475	no	1295	0.239417827605867	805	NA	FT	COFACTOR METABOLISM			Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins	pyridoxine metabolic process|thiamine biosynthetic process	protein binding	cellular_component
YNL243W	YNL243W	SLA2	hom	Verified	0.619306245906197	0.267857315292798	no	1296	0.269578185794623	905	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo	bipolar cellular bud site selection|fungal-type cell wall organization|actin filament organization|endocytosis|exocytosis	protein binding, bridging	incipient cellular bud site|mating projection tip|actin cortical patch
YNL108C_p	YNL108C	YNL108C	hom	Uncharacterized	0.617554112242446	0.268434650476391	no	1297	0.287264632749409	985	NA	FT		NUCLEUS		Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YJR018W_d	YJR018W	YJR018W	hom	Dubious	0.616870157279359	0.268660186098768	no	1298	0.26401265399338	936	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR106W	YJR106W	ECM27	hom	Verified	0.616772213227616	0.268692491152954	no	1299	0.241598402564245	829	NA	FT	CELL WALL ORG/BIOGENESIS			Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p	fungal-type cell wall organization	molecular_function	integral to membrane
YGL134W	YGL134W	PCL10	hom	Verified	0.615996757354265	0.268948329967245	no	1300	0.241430145093195	824	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY			Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate	negative regulation of glycogen biosynthetic process|regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YGL016W	YGL016W	KAP122	hom	Verified	0.615616639235013	0.269073783390818	no	1301	0.264454124571917	905	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance	protein import into nucleus|regulation of cell size	protein transporter activity	integral to membrane|nuclear pore|cytoplasm
YEL063C	YEL063C	CAN1	hom	Verified	0.615209068319836	0.269208329897615	no	1302	0.281475229178074	979	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity	mitochondrion|integral to membrane|membrane raft|plasma membrane
YEL005C	YEL005C	VAB2	hom	Verified	0.61510228379512	0.269243586973025	no	1303	0.267731522820983	904	NA					Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter	biological_process	molecular_function	cytoplasm
YDR483W	YDR483W	KRE2	hom	Verified	0.614688234943991	0.269380315490715	no	1304	0.312211600558942	1034	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication	N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YLR395C	YLR395C	COX8	hom	Verified	0.614236870467144	0.269529406141123	no	1305	0.283750833848548	986	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YPL163C	YPL163C	SVS1	hom	Verified	0.613922485037444	0.269633275532235	no	1306	0.276460161453158	930	NA					Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication	response to chemical stimulus	molecular_function	fungal-type cell wall|fungal-type vacuole
YMR129W	YMR129W	POM152	hom	Verified	0.613778470464538	0.269680863014876	no	1307	0.214698691850637	713	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	NUCLEAR PORE	Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210	nucleocytoplasmic transport|nuclear pore organization|protein import into nucleus|spindle pole body duplication associated with nuclear envelope	protein anchor|structural constituent of nuclear pore	mitochondrion|integral to membrane|nuclear pore transmembrane ring|nuclear envelope lumen|nuclear pore
YLR207W	YLR207W	HRD3	hom	Verified	0.612592814158497	0.270072805402754	no	1308	0.250182488571744	850	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events	ER-associated protein catabolic process	ubiquitin-protein ligase activity	Hrd1p ubiquitin ligase ERAD-M complex|luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YOR229W	YOR229W	WTM2	hom	Verified	0.611316921058811	0.270494895472674	no	1309	0.266824966203408	943	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS		Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats	negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter during meiosis|cellular protein complex localization|negative regulation of chromatin silencing at telomere|response to DNA damage stimulus|positive regulation of transcription from RNA polymerase II promoter	protein binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription corepressor activity	nucleus
YHR141C	YHR141C	RPL42B	hom	Verified	0.610651536479829	0.27071514822896	no	1310	0.294018043502352	972	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR318W	YLR318W	EST2	hom	Verified	0.609294638735336	0.271164580037705	no	1311	0.267008599186798	924	NA	FT		NUCLEUS|CHROMOSOME		Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia	telomere maintenance via telomerase|replicative cell aging	telomerase activity|telomeric template RNA reverse transcriptase activity|telomeric DNA binding	telomerase catalytic core complex|nucleolus|nucleus|telomerase holoenzyme complex
YMR095C	YMR095C	SNO1	hom	Verified	0.607885368122873	0.271631752305744	no	1312	0.243228695353655	820	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase	pyridoxine metabolic process|thiamine biosynthetic process|anti-apoptosis	molecular_function	cytoplasm
YPL137C	YPL137C	GIP3	hom	Verified	0.604852801032826	0.27263840330244	no	1313	0.276274617763016	946	NA	FT	CHROMOSOME SEGREGATION	ENDOPLASMIC RETICULUM|MITOCHONDRION		Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication	chromosome segregation|regulation of phosphoprotein phosphatase activity	protein phosphatase type 1 regulator activity|protein phosphatase 1 binding	mitochondrion|ribosome|endoplasmic reticulum|cytoplasm
YGR117C_p	YGR117C	YGR117C	hom	Uncharacterized	0.60384670020674	0.272972783847163	no	1314	0.238246125321734	826	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YDR117C	YDR117C	TMA64	hom	Verified	0.60375544462126	0.273003122962051	no	1315	0.250921145218116	844	NA	FT	TRANSLATION			Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity	biological_process	RNA binding	ribosome
YML042W	YML042W	CAT2	hom	Verified	0.601966465616387	0.273598229868475	no	1316	0.263791815477108	864	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes	carnitine metabolic process	carnitine O-acetyltransferase activity	mitochondrion|peroxisomal matrix|peroxisome
YIL015W	YIL015W	BAR1	hom	Verified	0.601861397308443	0.273633200967091	no	1317	0.274598931002519	923	NA	FT	SIGNALING|PROTEOLYSIS			Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|peptide catabolic process	aspartic-type endopeptidase activity	cell wall-bounded periplasmic space
YLR384C	YLR384C	IKI3	hom	Verified	0.601408253438932	0.273784051409381	no	1318	0.258823703820667	884	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YLR114C	YLR114C	AVL9	hom	Verified	0.600903681788479	0.273952070408623	no	1319	0.287397742035696	988	NA	FT	VESICLE-MEDIATED TRANSPORT			Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress	post-Golgi vesicle-mediated transport	molecular_function	cytoplasm
YLR403W	YLR403W	SFP1	hom	Verified	0.600568295464468	0.274063780011561	no	1320	0.263510704227571	923	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS	NUCLEUS		Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion	positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of cell size|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription factor binding transcription factor activity	nucleus|cytoplasm
YML011C	YML011C	RAD33	hom	Verified	0.600275814713611	0.274161217107299	no	1321	0.257928290613283	874	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	nucleotide-excision repair	molecular_function	nucleus
YGR214W	YGR214W	RPS0A	hom	Verified	0.599921970342321	0.274279119760415	no	1322	0.274155121968708	920	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YIL097W	YIL097W	FYV10	hom	Verified	0.599726254838023	0.274344343863435	no	1323	0.281401302236598	957	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis	ubiquitin-protein ligase activity	nucleus|GID complex|cytoplasm
YDL231C	YDL231C	BRE4	hom	Verified	0.598219822174264	0.274846633398329	no	1324	0.280681226946082	945	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport	endocytosis	molecular_function	integral to membrane
YOR295W	YOR295W	UAF30	hom	Verified	0.597967490730467	0.274930812520108	no	1325	0.263819225599151	927	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|chromatin organization	RNA polymerase I upstream control element sequence-specific DNA binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity	nucleolus|RNA polymerase I upstream activating factor complex
YNL305C	YNL305C	BXI1	hom	Verified	0.59785335439947	0.274968893184216	no	1326	0.25437459674275	846	NA	FT	SIGNALING	ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p	endoplasmic reticulum unfolded protein response|apoptotic process|calcium-mediated signaling	molecular_function	mitochondrion|integral to membrane|endoplasmic reticulum|fungal-type vacuole
YLL047W_d	YLL047W	YLL047W	hom	Dubious	0.597085305213593	0.275225214148567	no	1327	0.287572667690457	1002	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1	Unknown	Unknown	Unknown
YKL151C	YKL151C	YKL151C	hom	Verified	0.596459996512382	0.275433985179916	no	1328	0.24190403662664	807	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	nicotinamide nucleotide metabolic process	ATP-dependent NAD(P)H-hydrate dehydratase activity	cytoplasm
YER005W	YER005W	YND1	hom	Verified	0.595895631541852	0.275622475870407	no	1329	0.272110508985309	926	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity	protein glycosylation	nucleoside-triphosphatase activity|nucleoside-diphosphatase activity	COPI-coated vesicle|Golgi apparatus|membrane|Golgi membrane
YHL004W	YHL004W	MRP4	hom	Verified	0.595791536320697	0.275657249271097	no	1330	0.281828706257359	973	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome|tRNA binding	mitochondrion|mitochondrial small ribosomal subunit
YPL264C_p	YPL264C	YPL264C	hom	Uncharacterized	0.595582447837799	0.275727102582706	no	1331	0.261414395569511	879	NA					Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene	biological_process	molecular_function	integral to membrane
YER145C	YER145C	FTR1	hom	Verified	0.595317970412172	0.275815472966579	no	1332	0.283795903188789	1011	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress	iron assimilation by reduction and transport|high-affinity iron ion transport|transmembrane transport	iron ion transmembrane transporter activity	high affinity iron permease complex|integral to membrane|plasma membrane
YKL102C_d	YKL102C	YKL102C	hom	Dubious	0.595294066081658	0.27582346085522	no	1333	0.263998741354176	898	NA					Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site	Unknown	Unknown	Unknown
YGL089C	YGL089C	MF(ALPHA)2	hom	Verified	0.594610605742115	0.276051894538567	no	1334	0.268488784588989	933	NA	FT	SIGNALING			Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YKR023W_p	YKR023W	YKR023W	hom	Uncharacterized	0.593952307585165	0.276272006027311	no	1335	0.217810037698577	769	NA	FT		NUCLEUS|MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YBR223C	YBR223C	TDP1	hom	Verified	0.593793914098167	0.276324980025414	no	1336	0.292403623109463	1022	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI	DNA repair	3'-tyrosyl-DNA phosphodiesterase activity|5'-tyrosyl-DNA phosphodiesterase activity	nucleus
YER061C	YER061C	CEM1	hom	Verified	0.593501975797266	0.276422630547604	no	1337	0.296606217488036	1026	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration	fatty acid biosynthetic process	fatty acid synthase activity	mitochondrion
YPL086C	YPL086C	ELP3	hom	Verified	0.592866380253458	0.276635289590375	no	1338	0.281353376047749	959	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	histone acetyltransferase activity	Elongator holoenzyme complex|nucleus|cytoplasm
YJL108C	YJL108C	PRM10	hom	Verified	0.589629785249939	0.277719439175954	no	1339	0.293017534980476	1003	NA					Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	integral to membrane
YLR015W	YLR015W	BRE2	hom	Verified	0.589183581185998	0.277869065009104	no	1340	0.305576909582735	1033	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L	histone H3-K4 methylation|telomere maintenance|histone H3-K4 trimethylation|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YER044C	YER044C	ERG28	hom	Verified	0.588462520570165	0.278110941775252	no	1341	0.287840738440873	991	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p	ergosterol biosynthetic process	protein binding, bridging	endoplasmic reticulum membrane
YIL038C	YIL038C	NOT3	hom	Verified	0.588387372179938	0.278136155896462	no	1342	0.273883381777611	929	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation	regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of transcription elongation from RNA polymerase II promoter|protein ubiquitination	ubiquitin-protein ligase activity	CCR4-NOT core complex|cytoplasm
YJL094C	YJL094C	KHA1	hom	Verified	0.585985062425359	0.278942776506305	no	1343	0.264377019899206	895	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|GOLGI APPARATUS		Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies	monovalent inorganic cation transport	potassium:hydrogen antiporter activity	mitochondrion|integral to membrane|Golgi apparatus
YHR016C	YHR016C	YSC84	hom	Verified	0.585893982026692	0.278973380836941	no	1344	0.283744292876593	951	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication	endocytosis|actin filament organization|actin filament bundle assembly|actin cortical patch localization|actin cytoskeleton organization	actin filament binding	actin cortical patch
YHR063C	YHR063C	PAN5	hom	Verified	0.585301390165472	0.279172540142163	no	1345	0.295848048926687	993	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE	pantothenate biosynthetic process	2-dehydropantoate 2-reductase activity	cytoplasm
YGR104C	YGR104C	SRB5	hom	Verified	0.584801787291661	0.279340501226157	no	1346	0.294330052140657	999	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance	transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly	core mediator complex
YGL202W	YGL202W	ARO8	hom	Verified	0.584558105910311	0.27942244208087	no	1347	0.263060463747803	899	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis	aromatic amino acid family metabolic process	aromatic-amino-acid:2-oxoglutarate aminotransferase activity|2-aminoadipate transaminase activity	cytoplasm
YDR143C	YDR143C	SAN1	hom	Verified	0.584290792334155	0.27951234297689	no	1348	0.281999309056775	940	NA	FT	PROTEOLYSIS	NUCLEUS		Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition	nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to misfolded protein|response to stress	ubiquitin-protein ligase activity	nucleus|cytoplasm
YLR406C-A_p	YLR406C-A	YLR406C-A	hom	Uncharacterized	0.583807968518841	0.279674758244634	no	1349	0.281403435316876	938	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNR029C_p	YNR029C	YNR029C	hom	Uncharacterized	0.583683192076674	0.279716738764104	no	1350	0.259103083325152	913	NA					Putative protein of unknown function, deletion confers reduced fitness in saline	biological_process	molecular_function	cytoplasm
YJR014W	YJR014W	TMA22	hom	Verified	0.583513309204705	0.279773900071084	no	1351	0.223419537722204	730	NA	FT	TRANSLATION		RIBOSOME	Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress	biological_process	RNA binding	ribosome|cytoplasm
YKL074C	YKL074C	MUD2	hom	Verified	0.5834665844503	0.279789622767576	no	1352	0.246601906048269	845	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65	mRNA branch site recognition	pre-mRNA branch point binding	commitment complex
YHR035W_p	YHR035W	YHR035W	hom	Uncharacterized	0.583135561607737	0.279901022929011	no	1353	0.238451828682038	842	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Putative protein of unknown function; not an essential gene	biological_process	molecular_function	cellular_component
YLR437C	YLR437C	DIF1	hom	Verified	0.583116652676526	0.279907387060679	no	1354	0.26171970384811	913	NA	FT		NUCLEUS		Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein	biological_process	molecular_function	cytoplasm
YGR001C_p	YGR001C	YGR001C	hom	Uncharacterized	0.583008886698747	0.279943658925735	no	1355	0.251349480733531	850	NA					Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae	biological_process	methyltransferase activity	cytoplasm
YOR155C	YOR155C	ISN1	hom	Verified	0.581595808239726	0.280419483529847	no	1356	0.279160601516328	937	NA	FT	NUCLEOTIDE METABOLISM			Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms	nicotinamide riboside biosynthetic process|inosine salvage|nicotinic acid riboside biosynthetic process	IMP 5'-nucleotidase activity	cellular_component
YJL093C	YJL093C	TOK1	hom	Verified	0.581498590271808	0.280452234036869	no	1357	0.283168270109473	973	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin	cellular potassium ion homeostasis	potassium channel activity	integral to membrane|plasma membrane
YNR025C_d	YNR025C	YNR025C	hom	Dubious	0.581019719712997	0.280613581579221	no	1358	0.27988382904983	976	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase	Unknown	Unknown	Unknown
YGR254W	YGR254W	ENO1	hom	Verified	0.579993237838777	0.280959588968177	no	1359	0.266268022279829	896	NA	FT	MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress	regulation of vacuole fusion, non-autophagic|gluconeogenesis|glycolysis	phosphopyruvate hydratase activity	mitochondrion|phosphopyruvate hydratase complex|plasma membrane|fungal-type vacuole|cytoplasm
YOR279C	YOR279C	RFM1	hom	Verified	0.579895828425413	0.280992434525294	no	1360	0.313214008709556	1078	NA	FT	GENE SILENCING	NUCLEUS		DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance	chromatin silencing|chromatin silencing at silent mating-type cassette	unfolded protein binding	histone deacetylase complex|nucleus
YJR119C	YJR119C	JHD2	hom	Verified	0.579606959361135	0.281089849422316	no	1361	0.248982637998641	861	NA	FT	CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS	NUCLEUS		JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation	histone demethylation	histone demethylase activity (H3-K4 specific)	nucleus|cytoplasm
YOR293C-A_p	YOR293C-A	YOR293C-A	hom	Uncharacterized	0.578278471849472	0.281538063266258	no	1362	0.264200427776968	870	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YLL055W	YLL055W	YCT1	hom	Verified	0.577684917124541	0.281738432023359	no	1363	0.254833941306418	850	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene	cysteine transport	ion transmembrane transporter activity|cysteine transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YKL073W	YKL073W	LHS1	hom	Verified	0.577543812851477	0.281786075295709	no	1364	0.303350768056376	1026	NA	FT	PROTEIN LOCALIZATION|NUCLEOTIDE METABOLISM	ENDOPLASMIC RETICULUM		Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway	posttranslational protein targeting to membrane, translocation|response to unfolded protein	unfolded protein binding|adenyl-nucleotide exchange factor activity|ATP binding	endoplasmic reticulum lumen
YML051W	YML051W	GAL80	hom	Verified	0.577373360498356	0.281843633003609	no	1365	0.281429106011243	938	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM	NUCLEUS		Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding	negative regulation of kinase activity|galactose metabolic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity	RNA polymerase II activating transcription factor binding|kinase inhibitor activity	nucleus|cytoplasm
YMR291W	YMR291W	TDA1	hom	Verified	0.577331053676768	0.281857919889145	no	1366	0.267776856595099	912	NA	FT	PROTEIN PHOSPHORYLATION	NUCLEUS		Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress	protein phosphorylation	protein kinase activity	nucleus|cytoplasm
YMR306W	YMR306W	FKS3	hom	Verified	0.577157453756534	0.281916547710114	no	1367	0.292671500040776	1009	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	ascospore wall assembly	1,3-beta-D-glucan synthase activity	mitochondrion|integral to membrane
YMR034C_p	YMR034C	YMR034C	hom	Uncharacterized	0.577068696924508	0.281946524761097	no	1368	0.289952839302581	993	NA					Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene	biological_process	sterol transporter activity	integral to membrane
YNL319W_d	YNL319W	YNL319W	hom	Dubious	0.576078084919332	0.282281201779007	no	1369	0.294756223211458	1002	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14	Unknown	Unknown	Unknown
YKL106W	YKL106W	AAT1	hom	Verified	0.576022644992669	0.282299937735548	no	1370	0.266214012957235	925	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis	aspartate catabolic process|chronological cell aging|replicative cell aging|asparagine biosynthetic process from oxaloacetate|aspartate biosynthetic process	L-aspartate:2-oxoglutarate aminotransferase activity	mitochondrion
YBR274W	YBR274W	CHK1	hom	Verified	0.575861439411027	0.282354420658004	no	1371	0.270989404012452	911	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase	protein phosphorylation|replication fork protection|DNA damage checkpoint	protein serine/threonine kinase activity	nucleus
YBL039C	YBL039C	URA7	hom	Verified	0.57514475420985	0.282596701180693	no	1372	0.277721758662514	956	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication	pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process	CTP synthase activity	cytosol
YGR106C	YGR106C	VOA1	hom	Verified	0.574978612642399	0.28265288078268	no	1373	0.341921641140141	1141	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval	protein complex assembly	molecular_function	fungal-type vacuole membrane|endoplasmic reticulum membrane
YOL085C_d	YOL085C	YOL085C	hom	Dubious	0.574838591038229	0.282700232270563	no	1374	0.282875702075782	961	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A	Unknown	Unknown	Unknown
YDR022C	YDR022C	ATG31	hom	Verified	0.574381657736718	0.282854781161911	no	1375	0.272763137035844	931	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion	autophagy|mitochondrion degradation|piecemeal microautophagy of nucleus	molecular_function	pre-autophagosomal structure|cytoplasm
YMR036C	YMR036C	MIH1	hom	Verified	0.573964754550781	0.28299582603004	no	1376	0.254898884172204	865	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25	G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	protein tyrosine phosphatase activity	nucleus|cytoplasm
YNL297C	YNL297C	MON2	hom	Verified	0.573823964031272	0.283043465289833	no	1377	0.324749386000404	1077	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins	transport|endocytosis|protein targeting to vacuole|Golgi to endosome transport	guanyl-nucleotide exchange factor activity	cytosol|endosome|trans-Golgi network|extrinsic to membrane
YFL031W	YFL031W	HAC1	hom	Verified	0.573489858083827	0.283156532055231	no	1378	0.263286322176427	906	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING	NUCLEUS		Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress	endoplasmic reticulum unfolded protein response|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|negative regulation of transcription from RNA polymerase II promoter during meiosis|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YBR016W	YBR016W	YBR016W	hom	Verified	0.571931355661907	0.283684240177639	no	1379	0.289356533346733	980	NA	FT		PLASMA MEMBRANE		Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication	biological_process	molecular_function	cellular bud membrane|plasma membrane|mating projection membrane
YOL164W	YOL164W	BDS1	hom	Verified	0.571734932742733	0.283750782287538	no	1380	0.300645250216885	1015	NA					Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources	dodecyl sulfate metabolic process	arylsulfatase activity|alkyl sulfatase activity	cellular_component
YHR142W	YHR142W	CHS7	hom	Verified	0.570768590580274	0.284078258405422	no	1381	0.443330284050224	1450	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress	protein folding|ER to Golgi vesicle-mediated transport|fungal-type cell wall chitin biosynthetic process	unfolded protein binding	integral to membrane|endoplasmic reticulum membrane
YGL161C	YGL161C	YIP5	hom	Verified	0.570763874287127	0.284079857116233	no	1382	0.287416000746603	970	NA	FT		GOLGI APPARATUS		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YPL005W	YPL005W	AEP3	hom	Verified	0.570369647434136	0.284213505822262	no	1383	0.274606685930566	935	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA	mRNA metabolic process|mitochondrial translational initiation	molecular_function	mitochondrion|mitochondrial inner membrane|cytoplasm|extrinsic to membrane
YOR059C	YOR059C	YOR059C	hom	Verified	0.570099018079804	0.28430527055567	no	1384	0.267205895692374	954	NA	FT	LIPID METABOLISM			Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	lipid particle
YIL108W	YIL108W	YIL108W	hom	Verified	0.569696001155993	0.284441951376419	no	1385	0.25226865027791	841	NA	FT	PROTEOLYSIS			Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress	biological_process	molecular_function	cytoplasm
YDR206W	YDR206W	EBS1	hom	Verified	0.568558189754539	0.284828002759662	no	1386	0.292085419362049	961	NA	FT	TRANSLATION	NUCLEUS|CHROMOSOME		Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors	negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YNR042W_d	YNR042W	YNR042W	hom	Dubious	0.568485419480892	0.284852701703627	no	1387	0.274338268434305	922	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2	Unknown	Unknown	Unknown
YJL154C	YJL154C	VPS35	hom	Verified	0.567759930454554	0.285098995646314	no	1388	0.319125906268422	1076	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YGL242C_p	YGL242C	YGL242C	hom	Uncharacterized	0.567462333445665	0.285200055254	no	1389	0.305265183035931	1038	NA					Putative protein of unknown function; deletion mutant is viable	biological_process	molecular_function	cellular_component
YKR018C	YKR018C	YKR018C	hom	Verified	0.566821420626928	0.285417757860333	no	1390	0.282419309834577	966	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YNL129W	YNL129W	NRK1	hom	Verified	0.566737019300785	0.285446432848163	no	1391	0.265205476039541	905	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis	nicotinamide riboside metabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|NAD biosynthetic process	nicotinic acid riboside kinase activity|ribosylnicotinamide kinase activity	cytoplasm
YBL086C_p	YBL086C	YBL086C	hom	Uncharacterized	0.566362829601555	0.285573578709311	no	1392	0.267939007923491	908	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YLL044W_d	YLL044W	YLL044W	hom	Dubious	0.565597470520964	0.285833723872499	no	1393	0.266963394562714	920	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant	Unknown	Unknown	Unknown
YIR021W	YIR021W	MRS1	hom	Verified	0.565446391111949	0.28588508900186	no	1394	0.259629393933419	882	NA	FT	RNA PROCESSING	MITOCHONDRION		Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA	Group I intron splicing	endodeoxyribonuclease activity|RNA binding	mitochondrion
YDL112W	YDL112W	TRM3	hom	Verified	0.565386771391311	0.285905360176613	no	1395	0.302440613652641	1018	NA	FT	RNA PROCESSING			2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs	tRNA methylation	tRNA (guanine) methyltransferase activity	cytoplasm
YDL159W-A_p	YDL159W-A	YDL159W-A	hom	Uncharacterized	0.56377697119666	0.28645296308038	no	1396	0.279850950791457	954	NA					Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	cellular_component
YHR108W	YHR108W	GGA2	hom	Verified	0.562754942846059	0.286800882770841	no	1397	0.281295272547254	999	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to vacuole transport|Golgi to endosome transport	ubiquitin binding|phosphatidylinositol-4-phosphate binding	trans-Golgi network
YDR265W	YDR265W	PEX10	hom	Verified	0.562632734997691	0.286842498265199	no	1398	0.285035835787715	974	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders	protein import into peroxisome matrix|protein ubiquitination	ubiquitin-protein ligase activity|protein binding	peroxisomal membrane
YLL016W	YLL016W	SDC25	hom	pseudogene	0.562279894147715	0.286962667376998	no	1399	0.284459853828196	957	NA	FT	SIGNALING			Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication	Ras protein signal transduction	Ras guanyl-nucleotide exchange factor activity	cellular_component
YDR501W	YDR501W	PLM2	hom	Verified	0.561258524630823	0.28731065565109	no	1400	0.264636642785586	895	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication	response to DNA damage stimulus	chromatin binding	nuclear chromatin
YJL131C	YJL131C	AIM23	hom	Verified	0.560393635531069	0.287605485907791	no	1401	0.275908859946917	918	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss	positive regulation of mitochondrial translational initiation	ribosome binding|translation initiation factor activity	mitochondrion
YPR072W	YPR072W	NOT5	hom	Verified	0.558831697121447	0.288138293904516	no	1402	0.29084977179688	985	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation	deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination	ubiquitin-protein ligase activity	CCR4-NOT core complex|cytoplasm
YDR080W	YDR080W	VPS41	hom	Verified	0.558632778917256	0.288206182245743	no	1403	0.289259987787408	1009	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING			Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole organization|vesicle-mediated transport|protein transport|vacuole fusion, non-autophagic|vacuolar protein processing	Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding	endosome|fungal-type vacuole membrane|HOPS complex
YIL131C	YIL131C	FKH1	hom	Verified	0.558623644839184	0.288209299775643	no	1404	0.289199298195269	988	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication	mRNA 3'-end processing|termination of RNA polymerase II transcription|donor selection|negative regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|cellular response to methylmercury|positive regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription elongation from RNA polymerase II promoter|Unknown|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle|chromatin remodeling	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|centromeric DNA binding	nucleus
YGR072W	YGR072W	UPF3	hom	Verified	0.558455211674407	0.288266790139141	no	1405	0.278765716301122	915	NA	FT		NUCLEUS		Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|translational frameshifting|protein ubiquitination	molecular_function	nucleolus|nucleus|polysome|cytoplasm
YOR019W	YOR019W	YOR019W	hom	Verified	0.558345667011565	0.288304183317354	no	1406	0.282086690222836	955	NA	FT	CELL CYCLE			Protein of unknown function that may interact with ribosomes, based on co-purification experiments	mitochondrion degradation	molecular_function	ribosome
YBL100W-C_p	YBL100W-C	YBL100W-C	hom	Uncharacterized	0.557719680269494	0.288517908375763	no	1407	0.286368448464878	978	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YLR401C	YLR401C	DUS3	hom	Verified	0.556957195478088	0.288778337551358	no	1408	0.23335234757934	788	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	NUCLEUS		Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress	tRNA modification	tRNA dihydrouridine synthase activity	nucleus|cytoplasm
YNL278W	YNL278W	CAF120	hom	Verified	0.556911460702907	0.288793961931083	no	1409	0.276773266711793	923	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|SITE OF POLARIZED GROWTH		Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter	molecular_function	CCR4-NOT complex
YER020W	YER020W	GPA2	hom	Verified	0.556811050154353	0.288828266601362	no	1410	0.267698528443549	920	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	adenylate cyclase-activating G-protein coupled receptor signaling pathway|ascospore formation|replicative cell aging|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|regulation of cell size	GTPase activity	mitochondrion|plasma membrane
YJR066W	YJR066W	TOR1	hom	Verified	0.556518053281563	0.288928378213868	no	1411	0.268971144688754	922	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS|PLASMA MEMBRANE		PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication	regulation of cell cycle|G1 phase of mitotic cell cycle|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell growth|response to DNA damage stimulus|mitochondria-nucleus signaling pathway|ribosome biogenesis|meiosis|signal transduction|TOR signaling cascade|fungal-type cell wall organization|negative regulation of autophagy	protein binding|protein kinase activity	TORC1 complex|fungal-type vacuole membrane|endosome membrane|extrinsic to internal side of plasma membrane|plasma membrane|nucleus|Golgi membrane|cytoplasm
YDL174C	YDL174C	DLD1	hom	Verified	0.555495726574933	0.289277816161352	no	1412	0.267104963850903	931	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane	cellular carbohydrate metabolic process|aerobic respiration	D-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial inner membrane
YGR111W_p	YGR111W	YGR111W	hom	Uncharacterized	0.555196338248792	0.28938018663592	no	1413	0.320038538720887	1092	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	regulation of cell size	molecular_function	nucleus|cytoplasm
YOR003W	YOR003W	YSP3	hom	Verified	0.555028011973254	0.289437750264198	no	1414	0.275914365560838	921	NA	FT	PROTEOLYSIS			Putative precursor to the subtilisin-like protease III	protein catabolic process	peptidase activity	cellular_component
YDL227C	YDL227C	HO	hom	Verified	0.55456580135303	0.28959584308468	no	1415	0.257534611485609	870	NA	FT		NUCLEUS		Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p	mating type switching|gene conversion at mating-type locus, DNA double-strand break formation	endonuclease activity	nucleus
YLR444C_d	YLR444C	YLR444C	hom	Dubious	0.550232909649322	0.291079816971842	no	1416	0.280528693627562	958	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR091C	YPR091C	NVJ2	hom	Verified	0.550067728089001	0.291136460289031	no	1417	0.27024971685186	917	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments	biological_process	lipid binding	ribosome|nucleus-vacuole junction|endoplasmic reticulum
YML101C	YML101C	CUE4	hom	Verified	0.549751159254431	0.291245031032113	no	1418	0.22756547380399	772	NA	FT		ENDOPLASMIC RETICULUM		Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication	biological_process	molecular_function	endoplasmic reticulum|cytoplasm
YOL075C_p	YOL075C	YOL075C	hom	Uncharacterized	0.548480352562804	0.291681058190446	no	1419	0.256777940327218	852	NA	FT	NUCLEOTIDE METABOLISM			Putative ABC transporter	transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YER002W	YER002W	NOP16	hom	Verified	0.548362858959491	0.291721386844289	no	1420	0.304304730875157	1020	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis	ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YFR014C	YFR014C	CMK1	hom	Verified	0.548103425111483	0.291810444450839	no	1421	0.269284454300537	895	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication	signal transduction|protein phosphorylation	protein kinase activity|calmodulin-dependent protein kinase activity	cytoplasm
YKR032W_d	YKR032W	YKR032W	hom	Dubious	0.547915987606619	0.291874795267772	no	1422	0.276259224549902	961	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAR035W	YAR035W	YAT1	hom	Verified	0.547671747230609	0.29195865749434	no	1423	0.277945268637584	969	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated	carnitine metabolic process|alcohol metabolic process	carnitine O-acetyltransferase activity	mitochondrion
YMR101C	YMR101C	SRT1	hom	Verified	0.546423872462331	0.292387302020959	no	1424	0.271582998805405	882	NA	FT	CARBOHYDRATE METABOLISM			Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase	protein glycosylation	dehydrodolichyl diphosphate synthase activity|prenyltransferase activity	lipid particle
YJL060W	YJL060W	BNA3	hom	Verified	0.546030476603973	0.292522493992163	no	1425	0.29342016320039	980	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate	kynurenic acid biosynthetic process	arylformamidase activity|kynurenine-oxoglutarate transaminase activity	mitochondrion|cytoplasm
YOL002C	YOL002C	IZH2	hom	Verified	0.545647282332697	0.292654208072814	no	1426	0.291130899511935	1003	NA	FT	KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc	response to zinc ion|cellular zinc ion homeostasis|response to toxin|cellular lipid metabolic process	protein binding|metal ion binding	integral to membrane|plasma membrane|membrane
YCR010C	YCR010C	ADY2	hom	Verified	0.545115022755083	0.292837205566294	no	1427	0.307183808530248	1041	NA	FT	CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication	nitrogen utilization|ammonium transport|acetate transport|transmembrane transport	acetate transmembrane transporter activity|ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YDR521W_d	YDR521W	YDR521W	hom	Dubious	0.544973674028093	0.292885811949956	no	1428	0.269456580780363	884	NA					Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol	Unknown	Unknown	Unknown
YBR245C	YBR245C	ISW1	hom	Verified	0.542384982914002	0.293776661296496	no	1429	0.282496867615762	983	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions	termination of RNA polymerase I transcription|nucleosome positioning|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|regulation of transcriptional start site selection at RNA polymerase II promoter|heterochromatin maintenance involved in chromatin silencing|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	nucleosome binding|ATPase activity|rDNA binding|DNA binding	ISW1 complex|nucleolar chromatin
YPR023C	YPR023C	EAF3	hom	Verified	0.541685675078044	0.294017529845181	no	1430	0.270454089826999	938	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition	DNA repair|histone acetylation|regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|histone deacetylation	histone acetyltransferase activity	Rpd3S complex|histone acetyltransferase complex|Rpd3L complex|NuA4 histone acetyltransferase complex
YKL029C	YKL029C	MAE1	hom	Verified	0.541019673119512	0.294247011411708	no	1431	0.277620251695994	976	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids	pyruvate metabolic process|cellular amino acid metabolic process	malic enzyme activity	mitochondrion
YER004W	YER004W	FMP52	hom	Verified	0.541006848128267	0.294251431278248	no	1432	0.307942708527701	1015	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YOR191W	YOR191W	ULS1	hom	Verified	0.540884380779771	0.29429363864777	no	1433	0.281798950558127	952	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION		Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress	chromatin assembly or disassembly|mating type switching	SUMO binding|DNA-dependent ATPase activity	mitochondrion|nucleolus|nucleus
YDR115W	YDR115W	YDR115W	hom	Verified	0.538256591841023	0.295199957494303	no	1434	0.298989052319734	992	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrial large ribosomal subunit
YJL058C	YJL058C	BIT61	hom	Verified	0.536801153138879	0.29570248752831	no	1435	0.280645585233733	965	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication	fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity	molecular_function	TORC2 complex|plasma membrane|cytoplasm
YLR077W	YLR077W	FMP25	hom	Verified	0.535931132543653	0.296003073560191	no	1436	0.303081476716371	1034	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria	mitochondrial respiratory chain complex III assembly	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YHR025W	YHR025W	THR1	hom	Verified	0.535132203276086	0.296279221512121	no	1437	0.316283468929928	1077	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway	threonine biosynthetic process|methionine metabolic process|isoleucine metabolic process|homoserine metabolic process	homoserine kinase activity	cellular_component
YLR342W	YLR342W	FKS1	hom	Verified	0.53512166195875	0.296282865882335	no	1438	0.297904270171356	1030	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON		Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling	(1->3)-beta-D-glucan biosynthetic process|positive regulation of endocytosis|regulation of cell size	1,3-beta-D-glucan synthase activity	mitochondrion|1,3-beta-D-glucan synthase complex|integral to membrane|plasma membrane|cellular bud neck|cellular bud tip|actin cortical patch
YHR129C	YHR129C	ARP1	hom	Verified	0.53485554803268	0.296374874254209	no	1439	0.290725733499392	990	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin	nuclear migration|establishment of mitotic spindle orientation	structural constituent of cytoskeleton	cell cortex|dynactin complex|spindle pole body|astral microtubule
YDR348C	YDR348C	PAL1	hom	Verified	0.53457621642774	0.296471466701363	no	1440	0.300299925897118	1028	NA	FT		SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cell cortex|cellular bud neck|mating projection tip
YOR303W	YOR303W	CPA1	hom	Verified	0.534245311792871	0.296585911689298	no	1441	0.275728421672686	930	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader	arginine biosynthetic process	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carbamoyl-phosphate synthase complex
YOR108W	YOR108W	LEU9	hom	Verified	0.534220724704761	0.296594416061768	no	1442	0.281834215456383	979	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication	leucine biosynthetic process	2-isopropylmalate synthase activity	mitochondrion
YMR070W	YMR070W	MOT3	hom	Verified	0.533135109823353	0.296970028246836	no	1443	0.3263729644414	1113	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion	cellular hyperosmotic response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ergosterol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	nucleus
YMR251W	YMR251W	GTO3	hom	Verified	0.533088114365686	0.296986293130753	no	1444	0.308648732928538	1082	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Omega class glutathione transferase; putative cytosolic localization	glutathione metabolic process	glutathione transferase activity	cytoplasm
YOR067C	YOR067C	ALG8	hom	Verified	0.532756335917026	0.297101131520946	no	1445	0.330085808484472	1140	NA	FF|FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p	oligosaccharide-lipid intermediate biosynthetic process|protein N-linked glycosylation	dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	integral to membrane|endoplasmic reticulum membrane
YHR121W	YHR121W	LSM12	hom	Verified	0.531704039186293	0.297465496977109	no	1446	0.294167083494585	986	NA	FT		NUCLEUS		Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress	RNA metabolic process	RNA binding	ribosome|nucleus|cytoplasmic stress granule|cytoplasm
YJL155C	YJL155C	FBP26	hom	Verified	0.529769531713496	0.298135866189661	no	1447	0.292048171958531	1001	NA	FT	CARBOHYDRATE METABOLISM			Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress	glucose metabolic process	6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity	cytosol
YLR024C	YLR024C	UBR2	hom	Verified	0.52944228010092	0.298249337449574	no	1448	0.282318591807076	948	NA					Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex	protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YER016W	YER016W	BIM1	hom	Verified	0.529309983711876	0.298295215495429	no	1449	0.295978353941593	1011	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CHROMOSOME|CYTOSKELETON	KINETOCHORE	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally	nuclear migration along microtubule|microtubule nucleation|microtubule depolymerization|negative regulation of microtubule depolymerization|positive regulation of microtubule polymerization|mitotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint	microtubule plus-end binding|protein homodimerization activity|structural constituent of cytoskeleton	spindle midzone|microtubule plus end|cytoplasmic microtubule|spindle pole body|kinetochore|spindle pole|spindle
YER177W	YER177W	BMH1	hom	Verified	0.529178150838588	0.298340935998118	no	1450	0.294593591023648	1027	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	glycogen metabolic process|pseudohyphal growth|signal transduction involved in filamentous growth|ascospore formation|fungal-type cell wall chitin biosynthetic process|Ras protein signal transduction|DNA damage checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	DNA replication origin binding|phosphoserine binding	plasma membrane|nucleus
YKL081W	YKL081W	TEF4	hom	Verified	0.529086736030713	0.298372641124151	no	1451	0.307996050402044	1025	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex	translational elongation	translation elongation factor activity	mitochondrion|ribosome|eukaryotic translation elongation factor 1 complex
YOR156C	YOR156C	NFI1	hom	Verified	0.528528406153983	0.298566318293698	no	1452	0.295699508039241	1014	NA	FT	CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	RSC COMPLEX	SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length	protein sumoylation|chromosome segregation|chromosome condensation	SUMO ligase activity	nuclear chromatin|nucleus|cytoplasm
YBR077C	YBR077C	SLM4	hom	Verified	0.528041271626108	0.298735345442706	no	1453	0.32803819515151	1088	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|SIGNALING			Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4	signal transduction|microautophagy	phosphatidylinositol-3,4-bisphosphate binding	fungal-type vacuole membrane|EGO complex|late endosome membrane|cytoplasm
YAR030C_d	YAR030C	YAR030C	hom	Dubious	0.527565238476973	0.298900562616754	no	1454	0.294112485224291	1026	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9	Unknown	Unknown	Unknown
YBR241C_p	YBR241C	YBR241C	hom	Uncharacterized	0.52528865863158	0.299691270162789	no	1455	0.250351768304805	825	NA					Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene	transport|transmembrane transport	substrate-specific transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|membrane
YLL024C	YLL024C	SSA2	hom	Verified	0.52427336331581	0.300044210378355	no	1456	0.286811379492353	959	NA	FT	PROTEIN LOCALIZATION	MITOCHONDRION		ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity|ATP binding	cytosol|fungal-type vacuole membrane|mitochondrion|fungal-type cell wall|plasma membrane|polysome|chaperonin-containing T-complex|cytoplasm
YJR092W	YJR092W	BUD4	hom	Verified	0.523902108826762	0.300173313989202	no	1457	0.290074517095179	988	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p	cellular bud site selection|axial cellular bud site selection	GTP binding	cellular bud neck contractile ring
YOR298C-A	YOR298C-A	MBF1	hom	Verified	0.523806486341886	0.300206570740525	no	1458	0.270547871824728	911	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress	positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity	mitochondrion|nucleus
YLR239C	YLR239C	LIP2	hom	Verified	0.523200896839216	0.300417228698596	no	1459	0.376285233576771	1254	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups	protein lipoylation	ligase activity	mitochondrion
YDR157W_d	YDR157W	YDR157W	hom	Dubious	0.522942253541292	0.300507219675865	no	1460	0.298644504878113	991	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL127W	YDL127W	PCL2	hom	Verified	0.522374519497217	0.300704796726753	no	1461	0.251418890920165	882	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH		Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth	G1 phase of mitotic cell cycle|regulation of establishment or maintenance of cell polarity|regulation of cyclin-dependent protein kinase activity|septin ring organization	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|nucleus|cellular bud neck|cellular bud tip
YOR299W	YOR299W	BUD7	hom	Verified	0.521186862275258	0.301118302635485	no	1462	0.298106813428795	1001	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication	Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process|cellular bud site selection	molecular_function	trans-Golgi network transport vesicle|clathrin-coated vesicle|exomer complex
YLL063C	YLL063C	AYT1	hom	Verified	0.520777420498085	0.301260917105955	no	1463	0.26798094934425	913	NA					Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis	secondary metabolic process	trichothecene 3-O-acetyltransferase activity	cellular_component
YPR111W	YPR111W	DBF20	hom	Verified	0.520525599763895	0.30134864500163	no	1464	0.275850592405533	951	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs	cytokinesis after mitosis|protein phosphorylation|barrier septum assembly involved in cell cycle cytokinesis|regulation of mRNA catabolic process|exit from mitosis	protein serine/threonine kinase activity	spindle pole body|cellular bud neck|cytoplasm
YKL168C	YKL168C	KKQ8	hom	Verified	0.520245899399098	0.301446098926872	no	1465	0.289832012499937	975	NA	FT	PROTEIN PHOSPHORYLATION			Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication	biological_process	protein kinase activity	cytoplasm
YBL003C	YBL003C	HTA2	hom	Verified	0.520045892633173	0.301515794498752	no	1466	0.294672091249243	1017	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p	DNA repair|chromatin assembly or disassembly	DNA binding	replication fork protection complex|nuclear nucleosome
YFL014W	YFL014W	HSP12	hom	Verified	0.52003402815396	0.301519929095006	no	1467	0.261072348532255	858	NA	FT	MEMBRANE ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|PLASMA MEMBRANE		Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension	cellular response to oxidative stress|cell adhesion|plasma membrane organization|cellular response to osmotic stress|cellular response to heat	lipid binding	cytosol|endosome|nucleus|plasma membrane|cytoplasm
YLR352W_p	YLR352W	YLR352W	hom	Uncharacterized	0.520002374138795	0.301530960177883	no	1468	0.300769864954378	1006	NA					Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene	biological_process	molecular_function	SCF ubiquitin ligase complex
YML058W	YML058W	SML1	hom	Verified	0.519606765135157	0.301668840961597	no	1469	0.250745642164094	857	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	NUCLEUS		Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase	mitochondrion organization|response to DNA damage stimulus	enzyme inhibitor activity	nucleus|cytoplasm
YOR193W	YOR193W	PEX27	hom	Verified	0.519596958461998	0.301672259221113	no	1470	0.29853334502404	995	NA	FT	PEROXISOME ORGANIZATION			Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p	peroxisome organization	molecular_function	peroxisomal membrane
YLR267W_p	YLR267W	BOP2	hom	Uncharacterized	0.519434939263064	0.30172873590597	no	1471	0.251415213146688	821	NA					Protein of unknown function	biological_process	molecular_function	cellular_component
YOL032W	YOL032W	OPI10	hom	Verified	0.519431712066215	0.301729860891179	no	1472	0.266695366803559	914	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	NUCLEUS		Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress	inositol metabolic process	molecular_function	nucleus|cytoplasm
YML100W	YML100W	TSL1	hom	Verified	0.519204749729513	0.301808983593296	no	1473	0.270004024970966	910	NA	FT	CARBOHYDRATE METABOLISM			Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication	trehalose biosynthetic process|response to stress	enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YJR039W_p	YJR039W	YJR039W	hom	Uncharacterized	0.518869289768127	0.301925947378486	no	1474	0.265568364930355	922	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YDR257C	YDR257C	RKM4	hom	Verified	0.518386201153618	0.302094420158571	no	1475	0.278677152905165	942	NA	FT		NUCLEUS		Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein	peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	nucleus
YJL023C	YJL023C	PET130	hom	Verified	0.517353476146527	0.302454715135039	no	1476	0.297027796669584	961	NA	FT		MITOCHONDRION		Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YKL087C	YKL087C	CYT2	hom	Verified	0.516823706348445	0.30263961487307	no	1477	0.302882614728703	1044	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	MITOCHONDRION		Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1	cytochrome c-heme linkage	holocytochrome-c synthase activity	mitochondrion|mitochondrial intermembrane space
YDR481C	YDR481C	PHO8	hom	Verified	0.516607218050495	0.302715187982601	no	1478	0.328926566403541	1109	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN	nicotinamide nucleotide metabolic process|protein dephosphorylation	nucleotide phosphatase activity|alkaline phosphatase activity	fungal-type vacuole membrane
YLR037C	YLR037C	PAU23	hom	Verified	0.516411256026316	0.302783602938616	no	1479	0.302182573630274	1003	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth	biological_process	molecular_function	fungal-type cell wall
YFR034C	YFR034C	PHO4	hom	Verified	0.5162645972087	0.302834809514522	no	1480	0.332066708090648	1109	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability	cellular response to phosphate starvation|positive regulation of phosphate metabolic process|phosphate-containing compound metabolic process|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YHR045W_p	YHR045W	YHR045W	hom	Uncharacterized	0.516097856682097	0.302893032417985	no	1481	0.299144183920321	1021	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM		Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum	biological_process	molecular_function	endoplasmic reticulum
YHR030C	YHR030C	SLT2	hom	Verified	0.515903859591779	0.302960779147343	no	1482	0.369113928596164	1247	NA	FF|FT	PROTEIN LOCALIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH		Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway	protein phosphorylation|endoplasmic reticulum unfolded protein response|signal transduction|UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|regulation of transcription factor import into nucleus|barrier septum assembly|response to acid|regulation of cell size	MAP kinase activity|protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm|cellular bud tip
YMR285C	YMR285C	NGL2	hom	Verified	0.515391140556527	0.303139861056128	no	1483	0.281034076916021	954	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication	rRNA processing	endoribonuclease activity	intracellular
YNL328C	YNL328C	MDJ2	hom	Verified	0.515347838770571	0.30315498762146	no	1484	0.323512432737591	1092	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain	protein import into mitochondrial matrix	protein transporter activity|ATPase activator activity	mitochondrial inner membrane|presequence translocase-associated import motor
YGR008C	YGR008C	STF2	hom	Verified	0.514697712396386	0.303382136121771	no	1485	0.304864878077782	1042	NA	FT		MITOCHONDRION		Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress	cellular response to desiccation	molecular_function	cytoplasm
YKL085W	YKL085W	MDH1	hom	Verified	0.51339138862299	0.303838784054406	no	1486	0.30900593060347	1017	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated	chronological cell aging|replicative cell aging|tricarboxylic acid cycle|aerobic respiration	L-malate dehydrogenase activity|mRNA binding	mitochondrion|mitochondrial matrix
YDR223W	YDR223W	CRF1	hom	Verified	0.51289676088578	0.304011769674838	no	1487	0.303773047749757	1012	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS	NUCLEUS|CHROMOSOME		Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter	transcription corepressor activity	nuclear chromatin|nucleus|cytoplasm
YER019W	YER019W	ISC1	hom	Verified	0.5128063987464	0.304043376670019	no	1488	0.313480969863367	1042	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance	response to salt stress|ceramide biosynthetic process|sphingolipid catabolic process	inositol phosphosphingolipid phospholipase activity	mitochondrion|endoplasmic reticulum|integral to mitochondrial outer membrane
YDL197C	YDL197C	ASF2	hom	Verified	0.51152995769461	0.304490008385093	no	1489	0.286330828324219	959	NA	FT	GENE SILENCING	NUCLEUS|CHROMOSOME		Anti-silencing protein that causes derepression of silent loci when overexpressed	chromatin silencing at silent mating-type cassette	molecular_function	nuclear chromosome, telomeric region|nucleus
YPL188W	YPL188W	POS5	hom	Verified	0.511015342370621	0.304670156842649	no	1490	0.30649589999833	1056	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress	cellular response to oxidative stress|NADP biosynthetic process	NADH kinase activity	mitochondrion|mitochondrial matrix
YDR095C_d	YDR095C	YDR095C	hom	Dubious	0.510071956627063	0.305000525537965	no	1491	0.309286099867938	1029	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR350C	YDR350C	ATP22	hom	Verified	0.508483777565376	0.305557056502477	no	1492	0.315096087335028	1074	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane	proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrial inner membrane
YDR433W_d	YDR433W	YDR433W	hom	Dubious	0.507998850178922	0.305727074789849	no	1493	0.318396777983609	1094	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR435C	YDR435C	PPM1	hom	Verified	0.506780219694024	0.306154518370506	no	1494	0.33921397452678	1134	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS			Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits	cellular protein complex assembly|C-terminal protein methylation	protein C-terminal leucine carboxyl O-methyltransferase activity	cellular_component
YPL147W	YPL147W	PXA1	hom	Verified	0.50671222451436	0.306178375960733	no	1495	0.298745455391397	981	NA	FT	NUCLEOTIDE METABOLISM			Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder	fatty acid transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|integral to peroxisomal membrane
YGL140C_p	YGL140C	YGL140C	hom	Uncharacterized	0.505664286028874	0.306546171919298	no	1496	0.262231704540912	904	NA					Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains	biological_process	molecular_function	integral to membrane
YHR075C	YHR075C	PPE1	hom	Verified	0.50512140412285	0.306736784368645	no	1497	0.304573292809376	1039	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein	cellular protein modification process|mitochondrial translation	structural constituent of ribosome|carboxylesterase activity	mitochondrial small ribosomal subunit
YIR036C_p	YIR036C	IRC24	hom	Uncharacterized	0.504653178572629	0.306901226051568	no	1498	0.308810824081055	1047	NA	FT	OXIDATION-REDUCTION PROCESS			Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci	biological_process	molecular_function	integral to membrane|cytoplasm
YKR069W	YKR069W	MET1	hom	Verified	0.504608342021344	0.306916974770878	no	1499	0.307849025065336	1046	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis	siroheme biosynthetic process|methionine biosynthetic process|sulfate assimilation	uroporphyrin-III C-methyltransferase activity	intracellular
YGL250W	YGL250W	RMR1	hom	Verified	0.503806136153514	0.307198807643452	no	1500	0.298855918986025	1034	NA	FT	CELL CYCLE	NUCLEUS		Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus	meiotic gene conversion|reciprocal meiotic recombination	molecular_function	nucleus|cytoplasm
YKL191W	YKL191W	DPH2	hom	Verified	0.503326440177843	0.30736739001387	no	1501	0.293503325447629	976	NA					Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	molecular_function	cytoplasm
YBR188C	YBR188C	NTC20	hom	Verified	0.502934555558983	0.30750514253773	no	1502	0.302637637042388	1004	NA	FT	RNA PROCESSING	NUCLEUS		Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs	mRNA splicing, via spliceosome	first spliceosomal transesterification activity	Prp19 complex|U2-type catalytic step 1 spliceosome
YKL098W	YKL098W	MTC2	hom	Verified	0.50286114064117	0.307530951853387	no	1503	0.347121057881069	1166	NA					Protein of unknown function; mtc2 is synthetically sick with cdc13-1	biological_process	molecular_function	cellular_component
YBR196C-B_p	YBR196C-B	YBR196C-B	hom	Uncharacterized	0.50233254261199	0.307716810782306	no	1504	0.299148212280184	1021	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YPL073C_d	YPL073C	YPL073C	hom	Dubious	0.501929442494226	0.30785857690226	no	1505	0.294747288817355	1004	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments	Unknown	Unknown	Unknown
YBR054W	YBR054W	YRO2	hom	Verified	0.501546598492645	0.307993245717141	no	1506	0.29957674470993	1014	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane|cellular bud
YER010C	YER010C	YER010C	hom	Verified	0.500703550379769	0.308289886613559	no	1507	0.308817405212754	1061	NA					Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction	biological_process	molecular_function	cellular_component
YLR096W	YLR096W	KIN2	hom	Verified	0.499691170393167	0.308646275315756	no	1508	0.312473329476644	1048	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	PLASMA MEMBRANE		Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p	protein autophosphorylation|exocytosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	plasma membrane
YCR073C	YCR073C	SSK22	hom	Verified	0.49968638389973	0.308647960736301	no	1509	0.289322205850315	996	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p	MAPK cascade involved in osmosensory signaling pathway|protein phosphorylation	protein kinase activity|MAP kinase kinase kinase activity	cellular_component
YAL060W	YAL060W	BDH1	hom	Verified	0.499433881623472	0.308736877577575	no	1510	0.314884505575066	1062	NA	FT	OXIDATION-REDUCTION PROCESS			NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source	alcohol metabolic process|butanediol biosynthetic process	(R,R)-butanediol dehydrogenase activity	cytoplasm
YKL071W_p	YKL071W	YKL071W	hom	Uncharacterized	0.498358026951996	0.30911585760738	no	1511	0.313412480771757	1054	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	integral to membrane|cytoplasm
YHL041W_d	YHL041W	YHL041W	hom	Dubious	0.498321070608406	0.3091288794432	no	1512	0.275675279866806	946	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR050W	YKR050W	TRK2	hom	Verified	0.498242889861778	0.30915642778682	no	1513	0.324939332655331	1077	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication	cellular potassium ion homeostasis	potassium ion transmembrane transporter activity	integral to membrane|plasma membrane
YGR035W-A_p	YGR035W-A	YGR035W-A	hom	Uncharacterized	0.498000103852282	0.30924198449316	no	1514	0.291614087321915	1009	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR343W	YLR343W	GAS2	hom	Verified	0.49661310998244	0.309730953191769	no	1515	0.268225871613103	901	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p	ascospore wall assembly	1,3-beta-glucanosyltransferase activity	integral to membrane|cytoplasm
YIR035C_p	YIR035C	YIR035C	hom	Uncharacterized	0.496120899631641	0.309904557310066	no	1516	0.284952955225622	966	NA	FT	OXIDATION-REDUCTION PROCESS			Putative cytoplasmic short-chain dehydrogenase/reductase	biological_process	molecular_function	integral to membrane|cytoplasm
YGL037C	YGL037C	PNC1	hom	Verified	0.495828265060453	0.310007790530455	no	1517	0.289306055527704	976	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING	NUCLEUS		Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress	replicative cell aging|chromatin silencing at rDNA|nicotinate nucleotide salvage|chromatin silencing at telomere	nicotinamidase activity	nucleus|peroxisome|cytoplasm
YIL113W	YIL113W	SDP1	hom	Verified	0.494257760820319	0.310562075874565	no	1518	0.330123868141629	1106	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock	inactivation of MAPK activity involved in cell wall biogenesis|MAPK cascade involved in cell wall biogenesis	MAP kinase tyrosine phosphatase activity	nucleus|cytoplasm
YNL236W	YNL236W	SIN4	hom	Verified	0.493958436047219	0.310667766821345	no	1519	0.347799184562026	1173	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding	core mediator complex
YDR488C	YDR488C	PAC11	hom	Verified	0.492856629252607	0.311056947063496	no	1520	0.27362067303155	931	NA	FT		CYTOSKELETON		Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8	nuclear migration along microtubule|microtubule-based process	plus-end-directed microtubule motor activity|microtubule motor activity	cytoplasmic dynein complex|cytoplasmic microtubule
YCL047C	YCL047C	POF1	hom	Verified	0.491778811244231	0.311437858529376	no	1521	0.321894876037556	1079	NA	FT	PROTEOLYSIS			ATPase involved in the protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; also interacts with Ubc7p	pseudohyphal growth|ER-associated protein catabolic process|invasive growth in response to glucose limitation	ATPase activity	cellular_component
YKL132C	YKL132C	RMA1	hom	Verified	0.491753585032439	0.311446776140276	no	1522	0.290915707967166	990	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	tetrahydrofolylpolyglutamate synthase activity	mitochondrion
YDR386W	YDR386W	MUS81	hom	Verified	0.490624535862086	0.311846014725154	no	1523	0.361792474346771	1224	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	crossover junction endodeoxyribonuclease activity|endonuclease activity	Holliday junction resolvase complex|nucleus
YBL029W_p	YBL029W	YBL029W	hom	Uncharacterized	0.490480854300064	0.311896837265758	no	1524	0.323212889889506	1093	NA	FT		NUCLEUS		Non-essential protein of unknown function	biological_process	molecular_function	nucleus|cytoplasm
YJR104C	YJR104C	SOD1	hom	Verified	0.489780045751617	0.312144776144697	no	1525	0.394642263692181	1323	NA	FF|FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid	cellular copper ion homeostasis|fungal-type cell wall organization|superoxide metabolic process|cellular zinc ion homeostasis|positive regulation of sequence-specific DNA binding transcription factor activity|age-dependent response to reactive oxygen species involved in chronological cell aging	superoxide dismutase activity	cytosol|mitochondrion|nucleus|mitochondrial intermembrane space
YHL039W	YHL039W	EFM1	hom	Verified	0.489347693036236	0.312297780562525	no	1526	0.314258871203792	1073	NA					Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	cytoplasm
YMR010W_p	YMR010W	YMR010W	hom	Uncharacterized	0.48915143817819	0.312367243477147	no	1527	0.310758063892483	1017	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1	biological_process	molecular_function	integral to membrane|cytoplasm
YER175W-A_p	YER175W-A	YER175W-A	hom	Uncharacterized	0.48674547142069	0.313219358495424	no	1528	0.306719367088101	1068	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YGR031W	YGR031W	IMO32	hom	Verified	0.485921637810597	0.313511363184918	no	1529	0.309810965411173	1052	NA	FT		MITOCHONDRION		Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1	biological_process	molecular_function	mitochondrion
YBR195C	YBR195C	MSI1	hom	Verified	0.48580051288012	0.313554305318138	no	1530	0.304060399674122	1025	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase	DNA replication-dependent nucleosome assembly	histone binding	nucleus|CAF-1 complex|cytoplasm
YKL131W_d	YKL131W	YKL131W	hom	Dubious	0.485219059387896	0.313760481812268	no	1531	0.281470341680912	974	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR331C_d	YOR331C	YOR331C	hom	Dubious	0.485067834265721	0.313814113977513	no	1532	0.368664685388818	1208	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W	Unknown	Unknown	Unknown
YER014C-A	YER014C-A	BUD25	hom	Verified	0.481125727008134	0.315213572144266	no	1533	0.294324401321709	965	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION			Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern	cellular bud site selection	molecular_function	cellular_component
YDR209C_d	YDR209C	YDR209C	hom	Dubious	0.478984695826862	0.315974758087887	no	1534	0.304090807614981	1046	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.	Unknown	Unknown	Unknown
YBR120C	YBR120C	CBP6	hom	Verified	0.478635696427119	0.316098909521981	no	1535	0.311395038410709	1039	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly	ribosome binding	mitochondrion|mitochondrial ribosome
YCR043C_p	YCR043C	YCR043C	hom	Uncharacterized	0.478311370574738	0.316214302295378	no	1536	0.327223117568191	1089	NA	FT		GOLGI APPARATUS|SITE OF POLARIZED GROWTH		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene	biological_process	molecular_function	Golgi apparatus|mating projection tip
YOL151W	YOL151W	GRE2	hom	Verified	0.477534182992236	0.31649089280208	no	1537	0.286456487186394	976	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress	ergosterol metabolic process|filamentous growth	methylglyoxal reductase (NADPH-dependent) activity|3-methylbutanol:NAD(P) oxidoreductase activity	nucleus|cytoplasm
YGR088W	YGR088W	CTT1	hom	Verified	0.477333858612643	0.316562202176267	no	1538	0.273399565112118	935	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide	response to reactive oxygen species	catalase activity	cytoplasm
YKR088C	YKR088C	TVP38	hom	Verified	0.477316777802006	0.316568282739845	no	1539	0.314805265025281	1098	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	vesicle-mediated transport|mitotic spindle elongation	molecular_function	integral to membrane|integral to Golgi membrane|cytoplasm
YMR031W-A_d	YMR031W-A	YMR031W-A	hom	Dubious	0.476888922631861	0.316720610215258	no	1540	0.316377197032357	1047	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C	Unknown	Unknown	Unknown
YBL002W	YBL002W	HTB2	hom	Verified	0.475692110619125	0.317146871173643	no	1541	0.299518160832496	1015	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation	chromatin assembly or disassembly	DNA binding	replication fork protection complex|nuclear nucleosome
YGR142W	YGR142W	BTN2	hom	Verified	0.475231349673085	0.31731104222573	no	1542	0.317192557849627	1072	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS			v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication	intracellular protein transport|amino acid transport|retrograde transport, endosome to Golgi|regulation of pH	SNARE binding	cytosol|late endosome|perinuclear region of cytoplasm
YJL159W	YJL159W	HSP150	hom	Verified	0.475008743624562	0.317390370574029	no	1543	0.300140173558836	991	NA	FT	CELL WALL ORG/BIOGENESIS			O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication	fungal-type cell wall organization	structural constituent of cell wall|ATPase activity	fungal-type cell wall|extracellular region
YBR220C_p	YBR220C	YBR220C	hom	Uncharacterized	0.473627859202758	0.317882652679822	no	1544	0.319584008872992	1067	NA					Putative protein of unknown function; YBR220C is not an essential gene	biological_process	molecular_function	integral to membrane
YNL011C_p	YNL011C	YNL011C	hom	Uncharacterized	0.473525879422413	0.3179190210157	no	1545	0.276511159963223	973	NA					Putative protein of unknown function; YNL011C is not an essential gene	biological_process	molecular_function	cellular_component
YLR112W_d	YLR112W	YLR112W	hom	Dubious	0.472068028668703	0.318439116002479	no	1546	0.298035480051235	980	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML058W-A	YML058W-A	HUG1	hom	Verified	0.471732973798568	0.318558699007327	no	1547	0.311473749156176	1043	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress	cell cycle arrest|cell cycle checkpoint|response to DNA damage stimulus	molecular_function	cytoplasm
YLR203C	YLR203C	MSS51	hom	Verified	0.471611170346445	0.318602176043384	no	1548	0.304135170206107	993	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	extrinsic to mitochondrial inner membrane|mitochondrion
YPL107W_p	YPL107W	YPL107W	hom	Uncharacterized	0.470594955030995	0.318965005503061	no	1549	0.305047788728276	1041	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene	biological_process	molecular_function	mitochondrion
YNL128W	YNL128W	TEP1	hom	Verified	0.47056922722215	0.318974193612333	no	1550	0.305155453603571	1018	NA	FT	CELL WALL ORG/BIOGENESIS			PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1	ascospore wall assembly|phosphatidylinositol dephosphorylation	molecular_function	cytoplasm
YPR120C	YPR120C	CLB5	hom	Verified	0.470546241272993	0.318982402622068	no	1551	0.336101589669955	1098	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase	spindle assembly|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation|premeiotic DNA replication|positive regulation of DNA replication	cyclin-dependent protein kinase regulator activity	nucleus
YPL112C	YPL112C	PEX25	hom	Verified	0.469829979488331	0.319238246841585	no	1552	0.323147077837215	1107	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p	protein import into peroxisome matrix|peroxisome organization	molecular_function	peroxisomal membrane
YKL117W	YKL117W	SBA1	hom	Verified	0.467578872727336	0.320042888191868	no	1553	0.305665813500126	989	NA	FT		NUCLEUS		Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress	protein folding|positive regulation of telomere maintenance via telomerase|regulation of telomerase activity	chaperone binding	nucleus|cytoplasm
YMR300C	YMR300C	ADE4	hom	Verified	0.467466872366072	0.320082944042461	no	1554	0.32898390521902	1115	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway	'de novo' IMP biosynthetic process	amidophosphoribosyltransferase activity	cytoplasm
YMR272W-B_p	YMR272W-B	YMR272W-B	hom	Uncharacterized	0.46728053612731	0.320149590050668	no	1555	0.278760562686967	962	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YER065C	YER065C	ICL1	hom	Verified	0.465097960512947	0.320930653225855	no	1556	0.28136805284997	961	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose	glyoxylate cycle	isocitrate lyase activity	cellular_component
YPL004C	YPL004C	LSP1	hom	Verified	0.465091689036513	0.320932898699938	no	1557	0.309837259097656	1047	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family	negative regulation of protein kinase activity|endocytosis|response to heat	lipid binding	mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YBR113W_d	YBR113W	YBR113W	hom	Dubious	0.463807846248108	0.321392710675626	no	1558	0.290040662275051	960	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8	Unknown	Unknown	Unknown
YDR119W_p	YDR119W	VBA4	hom	Uncharacterized	0.463045752727394	0.321665786233948	no	1559	0.29287107798066	989	NA					Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YKL010C	YKL010C	UFD4	hom	Verified	0.462389341172593	0.321901070788229	no	1560	0.324118967864956	1070	NA	FT	PROTEOLYSIS	MITOCHONDRION		Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress	protein monoubiquitination|protein polyubiquitination	ubiquitin-protein ligase activity	mitochondrion|cytoplasm
YIR034C	YIR034C	LYS1	hom	Verified	0.46119102928655	0.322330778576647	no	1561	0.34149759567105	1156	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity	lysine biosynthetic process|lysine biosynthetic process via aminoadipic acid	saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|mRNA binding	cytoplasm
YGL132W_d	YGL132W	YGL132W	hom	Dubious	0.458795400917206	0.323190548860603	no	1562	0.310888626437783	1054	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C	Unknown	Unknown	Unknown
YGL156W	YGL156W	AMS1	hom	Verified	0.45861842288152	0.323254102297818	no	1563	0.324233565715505	1099	NA	FT	CARBOHYDRATE METABOLISM			Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway	oligosaccharide catabolic process|cellular carbohydrate metabolic process	alpha-mannosidase activity	fungal-type vacuole membrane
YBR085W	YBR085W	AAC3	hom	Verified	0.458489980339481	0.323300229698532	no	1564	0.311489088094743	1036	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication	heme biosynthetic process|heme transport|anaerobic respiration|transmembrane transport	ATP:ADP antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YBL104C	YBL104C	SEA4	hom	Verified	0.458327599591585	0.32335854917028	no	1565	0.424958788739922	1413	NA					Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites	biological_process	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane|cytoplasm
YDR154C_d	YDR154C	YDR154C	hom	Dubious	0.458192160285763	0.323407195872468	no	1566	0.294580950532796	972	NA					Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein	Unknown	Unknown	Unknown
YLR193C	YLR193C	UPS1	hom	Verified	0.458018755538725	0.323469483300035	no	1567	0.292480541565265	1016	NA	FT	LIPID METABOLISM	MITOCHONDRION		Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI	Unknown|cardiolipin metabolic process	molecular_function	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial intermembrane space
YOR268C_p	YOR268C	YOR268C	hom	Uncharacterized	0.457706823155243	0.323581542661209	no	1568	0.285843470905462	982	NA					Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene	biological_process	molecular_function	cellular_component
YOR316C-A_p	YOR316C-A	YOR316C-A	hom	Uncharacterized	0.456413442261433	0.324046350628181	no	1569	0.30163447804877	1004	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YGL080W	YGL080W	FMP37	hom	Verified	0.456380640755619	0.324058142220478	no	1570	0.321988817181698	1077	NA	FT		MITOCHONDRION		Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|integral to mitochondrial inner membrane
YIL043C	YIL043C	CBR1	hom	Verified	0.456303474424986	0.324085882920788	no	1571	0.333703646490853	1100	NA	FT	OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia	biological_process	cytochrome-b5 reductase activity	mitochondrial outer membrane|mitochondrion
YHR007C-A_p	YHR007C-A	YHR007C-A	hom	Uncharacterized	0.455913528277905	0.324226080488319	no	1572	0.305108366885453	1035	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YOR083W	YOR083W	WHI5	hom	Verified	0.455632347422347	0.324327189075016	no	1573	0.310237739383172	1039	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1	negative regulation of transcription involved in G1/S phase of mitotic cell cycle|regulation of cell size	RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	SBF transcription complex|nucleus|cytoplasm
YJL057C	YJL057C	IKS1	hom	Verified	0.454798373705368	0.324627150180848	no	1574	0.321786783486977	1084	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p	protein phosphorylation	protein kinase activity	cellular_component
YKR077W	YKR077W	MSA2	hom	Verified	0.454628759371843	0.324688170474126	no	1575	0.324354625510653	1105	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation	regulation of transcription involved in G1 phase of mitotic cell cycle	molecular_function	nucleus|cytoplasm
YDR110W	YDR110W	FOB1	hom	Verified	0.453784868937532	0.324991837623211	no	1576	0.320187163238049	1070	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases	extrachromosomal circular DNA accumulation involved in cell aging|negative regulation of DNA replication|rDNA condensation|chromatin silencing at rDNA|replicative cell aging|protein localization to nucleolar rDNA repeats|DNA recombination	rDNA spacer replication fork barrier binding	nucleolus|rDNA heterochromatin
YFR016C	YFR016C	YFR016C	hom	Verified	0.453750913068773	0.325004058803321	no	1577	0.291997886251747	994	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene	biological_process	molecular_function	cellular bud|cytoplasm
YLR285W	YLR285W	NNT1	hom	Verified	0.453380075123325	0.325137540691022	no	1578	0.311232092870126	1047	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING			S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination	chromatin silencing at rDNA|nicotinamide metabolic process	S-adenosylmethionine-dependent methyltransferase activity|nicotinamide N-methyltransferase activity	cytoplasm
YDR248C_p	YDR248C	YDR248C	hom	Uncharacterized	0.451867507033588	0.325682216869297	no	1579	0.313111625526167	1033	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM			Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1	biological_process	molecular_function	cytoplasm
YPL051W	YPL051W	ARL3	hom	Verified	0.450856196504188	0.326046597858849	no	1580	0.356423144763223	1172	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor	intracellular protein transport|Golgi to plasma membrane protein transport|protein localization to organelle	GTPase activity	Golgi apparatus|nuclear outer membrane-endoplasmic reticulum membrane network
YDL077C	YDL077C	VAM6	hom	Verified	0.450706824928647	0.326100431387276	no	1581	0.365191013764664	1207	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION			Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle-mediated transport|vacuole organization|vacuole fusion, non-autophagic	Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding	fungal-type vacuole membrane|HOPS complex|fungal-type vacuole
YPL273W	YPL273W	SAM4	hom	Verified	0.450547773306773	0.326157757589466	no	1582	0.315659418018409	1099	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio	homocysteine metabolic process|L-methionine biosynthetic process from S-adenosylmethionine|S-adenosylhomocysteine metabolic process	homocysteine S-methyltransferase activity	nucleus|cytoplasm
YGR144W	YGR144W	THI4	hom	Verified	0.450515600637788	0.326169353927588	no	1583	0.344460508649402	1149	NA	FT	MITOCHONDRION ORGANIZATION	NUCLEUS		Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents	thiamine biosynthetic process|mitochondrial genome maintenance|thiazole biosynthetic process	ferrous iron binding	cytosol
YLR125W_p	YLR125W	YLR125W	hom	Uncharacterized	0.448997778081489	0.326716629743099	no	1584	0.319381970491934	1079	NA					Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene	biological_process	molecular_function	cellular_component
YMR132C_p	YMR132C	JLP2	hom	Uncharacterized	0.448310741165545	0.326964474892736	no	1585	0.305491875833296	1014	NA					Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)	biological_process	molecular_function	cytoplasm
YKL046C	YKL046C	DCW1	hom	Verified	0.448249797559316	0.326986463683554	no	1586	0.290376780280889	1000	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p	fungal-type cell wall biogenesis|budding cell bud growth	mannosidase activity	anchored to plasma membrane
YER049W	YER049W	TPA1	hom	Verified	0.448083360970597	0.32704651798715	no	1587	0.315875791010513	1035	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS	NUCLEUS		Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|translational termination	poly(A) RNA binding	nucleus
YOL044W	YOL044W	PEX15	hom	Verified	0.448034421714726	0.327064177293822	no	1588	0.31579535394164	1082	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly	protein import into peroxisome matrix, receptor recycling	protein anchor	integral to peroxisomal membrane
YJL133W	YJL133W	MRS3	hom	Verified	0.447191275492288	0.327368480079062	no	1589	0.308859664253719	1039	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication	mitochondrial iron ion transport|RNA splicing	iron ion transmembrane transporter activity	mitochondrion|integral to membrane
YER184C_p	YER184C	YER184C	hom	Uncharacterized	0.447180628160782	0.327372323577975	no	1590	0.337879997518667	1154	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source	biological_process	sequence-specific DNA binding	cellular_component
YLR307C-A_p	YLR307C-A	YLR307C-A	hom	Uncharacterized	0.446891864660617	0.32747656908647	no	1591	0.311879783234925	1030	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YIL006W	YIL006W	YIA6	hom	Verified	0.446838795504779	0.327495728861776	no	1592	0.340068401494783	1153	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs	transport|mitochondrial pyruvate transport|NAD transmembrane transport	pyruvate secondary active transmembrane transporter activity|transporter activity|NAD transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YFR017C	YFR017C	IGD1	hom	Verified	0.445452508442277	0.327996386597492	no	1593	0.337012677545936	1131	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication	negative regulation of glycogen catabolic process	enzyme inhibitor activity	cytoplasm
YDR431W_d	YDR431W	YDR431W	hom	Dubious	0.445451795268893	0.327996644239801	no	1594	0.302785550008448	1025	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR015W_d	YOR015W	YOR015W	hom	Dubious	0.444505922441932	0.32833842397215	no	1595	0.319793795569522	1064	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR058W	YKR058W	GLG1	hom	Verified	0.444417178527763	0.328370497893626	no	1596	0.320321736000232	1112	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication	glycogen biosynthetic process	glycogenin glucosyltransferase activity	cellular_component
YOR330C	YOR330C	MIP1	hom	Verified	0.444098374723427	0.328485730742892	no	1597	0.305018284642398	1006	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit	mitochondrial DNA replication	3'-5' exonuclease activity|DNA-directed DNA polymerase activity	mitochondrion
YER134C	YER134C	YER134C	hom	Verified	0.443192767737525	0.328813154807516	no	1598	0.327825410730016	1107	NA	FT		NUCLEUS		Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene	biological_process	acid phosphatase activity	nucleus|cytoplasm
YLR202C_d	YLR202C	YLR202C	hom	Dubious	0.442774641433394	0.328964373597673	no	1599	0.329022859037409	1122	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron	Unknown	Unknown	Unknown
YLL046C	YLL046C	RNP1	hom	Verified	0.44275150621939	0.328972741454266	no	1600	0.30655476406151	1032	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS			Ribonucleoprotein that contains two RNA recognition motifs (RRM)	ribosome biogenesis	RNA binding	cytoplasm
YDL215C	YDL215C	GDH2	hom	Verified	0.442670513490923	0.329002036673191	no	1601	0.319765350165838	1068	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels	nitrogen compound metabolic process	glutamate dehydrogenase (NAD+) activity	mitochondrion
YDR159W	YDR159W	SAC3	hom	Verified	0.441826161781988	0.329307502762361	no	1602	0.396715983447531	1313	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)	ribosomal small subunit biogenesis|actin filament-based process|mRNA export from nucleus|mRNA 3'-end processing|mitosis|protein export from nucleus|transcription-coupled nucleotide-excision repair|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery	protein binding	transcription export complex 2|nuclear pore
YDL186W_p	YDL186W	YDL186W	hom	Uncharacterized	0.441508016972377	0.329422629456457	no	1603	0.32467064229555	1077	NA					Putative protein of unknown function; YDL186W is not an essential gene	biological_process	molecular_function	cellular_component
YLR095C	YLR095C	IOC2	hom	Verified	0.441247202050271	0.329517022314362	no	1604	0.327424628495221	1131	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif	chromatin remodeling	protein binding|nucleosome binding|ATPase activity|DNA binding	ISW1 complex
YPL155C	YPL155C	KIP2	hom	Verified	0.441221894683214	0.329526182010861	no	1605	0.290931909572285	1013	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	MITOCHONDRION|CYTOSKELETON		Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle	nuclear migration along microtubule|mitotic anaphase B|negative regulation of microtubule depolymerization	microtubule motor activity	mitochondrion|kinesin complex|cytoplasmic microtubule
YBR062C_p	YBR062C	YBR062C	hom	Uncharacterized	0.440760292569642	0.329693271274311	no	1606	0.318855206596491	1073	NA					Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.	biological_process	molecular_function	cellular_component
YNL296W_d	YNL296W	YNL296W	hom	Dubious	0.440528492250065	0.329777190441006	no	1607	0.370490770503819	1227	NA					Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog	Unknown	Unknown	Unknown
YJL043W_p	YJL043W	YJL043W	hom	Uncharacterized	0.438313480322265	0.330579527640478	no	1608	0.289430205177476	977	NA	FT		MITOCHONDRION		Putative protein of unknown function; YJL043W is a non-essential gene	biological_process	molecular_function	mitochondrion|cytoplasm
YER123W	YER123W	YCK3	hom	Verified	0.437408641365423	0.330907509160219	no	1609	0.366015947943114	1236	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE		Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway	vesicle-mediated transport|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	fungal-type vacuole membrane|plasma membrane|nucleus|fungal-type vacuole
YBL046W	YBL046W	PSY4	hom	Verified	0.437398642918262	0.330911134073229	no	1610	0.327024146962021	1140	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2	Unknown|protein dephosphorylation	protein phosphatase regulator activity	nucleus|cytoplasm
YPR076W_d	YPR076W	YPR076W	hom	Dubious	0.436715983292934	0.331158668157461	no	1611	0.341630324816582	1144	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL041W_d	YDL041W	YDL041W	hom	Dubious	0.436617987553464	0.331194207717428	no	1612	0.357477040442427	1219	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C	Unknown	Unknown	Unknown
YNR002C	YNR002C	ATO2	hom	Verified	0.435997301389424	0.33141934376059	no	1613	0.305398829026773	1022	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication	ammonium transport|nitrogen utilization	ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YNL220W	YNL220W	ADE12	hom	Verified	0.435386117434269	0.331641092693154	no	1614	0.324323112280109	1100	NA	FT	NUCLEOTIDE METABOLISM			Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence	purine nucleotide biosynthetic process	DNA replication origin binding|adenylosuccinate synthase activity	cytoplasm
YMR144W_p	YMR144W	YMR144W	hom	Uncharacterized	0.434040335615733	0.332129575371414	no	1615	0.328016313716326	1080	NA	FT		NUCLEUS		Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene	biological_process	molecular_function	nucleus
YBL071C_d	YBL071C	YBL071C	hom	Dubious	0.433124426215222	0.332462189169005	no	1616	0.324301898164305	1078	NA					Dubious open reading frame, predicted protein contains a peroxisomal targeting signal	Unknown	Unknown	Unknown
YIL016W	YIL016W	SNL1	hom	Verified	0.432881003224972	0.332550610781058	no	1617	0.326222099821373	1124	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein	protein folding|nuclear pore organization	ribosome binding	nuclear envelope|mitochondrion|cytosolic ribosome|endoplasmic reticulum membrane|membrane
YDL191W	YDL191W	RPL35A	hom	Verified	0.432450495309237	0.3327070124261	no	1618	0.336327326674863	1140	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication	cytoplasmic translation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic large ribosomal subunit|preribosome, large subunit precursor
YDL240W	YDL240W	LRG1	hom	Verified	0.43241221601677	0.332720920535936	no	1619	0.338760291143189	1133	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	MITOCHONDRION|SITE OF POLARIZED GROWTH		Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis	fungal-type cell wall biogenesis|small GTPase mediated signal transduction	Rho GTPase activator activity	mitochondrion|cellular bud neck|cytoplasm
YGL007W_d	YGL007W	BRP1	hom	Dubious	0.432370851766536	0.332735949769884	no	1620	0.374402938970229	1235	NA	FF				Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1	Unknown	Unknown	Unknown
YDR219C	YDR219C	MFB1	hom	Verified	0.432031075425032	0.332859413843082	no	1621	0.318279381783928	1085	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|mitochondrion organization	molecular_function	extrinsic to mitochondrial outer membrane|SCF ubiquitin ligase complex
YDR391C_p	YDR391C	YDR391C	hom	Uncharacterized	0.430497536097244	0.333416879313705	no	1622	0.334657982631657	1097	NA	FT		NUCLEUS		Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YMR194C-B	YMR194C-B	CMC4	hom	Verified	0.430118589812402	0.333554688967651	no	1623	0.321331699166861	1047	NA	FT		MITOCHONDRION		Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs	biological_process	molecular_function	mitochondrial intermembrane space
YLR130C	YLR130C	ZRT2	hom	Verified	0.427736468321149	0.334421497933962	no	1624	0.332906008893388	1083	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor	low-affinity zinc ion transport	low-affinity zinc ion transmembrane transporter activity	integral to membrane|plasma membrane
YNL016W	YNL016W	PUB1	hom	Verified	0.427419891520456	0.334536760854199	no	1625	0.313341352025872	1066	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|stress granule assembly|regulation of mRNA stability	mRNA binding|poly(U) RNA binding	nucleus|cytoplasmic stress granule|cytoplasm
YNR031C	YNR031C	SSK2	hom	Verified	0.427218459482415	0.334610108665926	no	1626	0.335044140599522	1136	NA	FT	SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress	MAPK cascade involved in osmosensory signaling pathway|protein autophosphorylation|protein phosphorylation|response to osmotic stress|actin cytoskeleton organization|osmosensory signaling pathway via two-component system	MAP kinase kinase kinase activity	cytosol|cellular bud neck|cellular bud tip
YBR015C	YBR015C	MNN2	hom	Verified	0.427123632787888	0.334644640266816	no	1627	0.420697195073976	1399	NA	FF|FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment	protein glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YIL023C	YIL023C	YKE4	hom	Verified	0.426771003904917	0.334773064054588	no	1628	0.305833657078296	1016	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family	zinc ion transport	zinc ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YDR049W	YDR049W	VMS1	hom	Verified	0.425594975131733	0.335201501201021	no	1629	0.334900467227751	1131	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans	ER-associated protein catabolic process|mitochondria-associated protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process	molecular_function	cytosol|mitochondrion|endoplasmic reticulum membrane|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytoplasm
YMR273C	YMR273C	ZDS1	hom	Verified	0.425541971255855	0.335220816012673	no	1630	0.354028351026897	1196	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL WALL ORG/BIOGENESIS|RNA LOCALIZATION|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|SITE OF POLARIZED GROWTH	NUCLEAR PORE	Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication	mRNA export from nucleus|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|chromatin silencing|establishment of cell polarity|regulation of protein localization|cell aging	protein phosphatase type 2A regulator activity	incipient cellular bud site|nuclear pore|cellular bud neck|cellular bud tip|cytoplasm
YEL024W	YEL024W	RIP1	hom	Verified	0.425256470217681	0.335324861156575	no	1631	0.351418553177981	1174	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|mitochondrial respiratory chain complex III
YOL050C_d	YOL050C	YOL050C	hom	Dubious	0.423965896009688	0.335795342639595	no	1632	0.348128307329043	1150	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	Unknown	Unknown	Unknown
YAL053W	YAL053W	FLC2	hom	Verified	0.423604356468947	0.335927188822352	no	1633	0.352215433572296	1214	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication	protein folding|fungal-type cell wall biogenesis|FAD transport|transmembrane transport	FAD transmembrane transporter activity	integral to membrane|endoplasmic reticulum|cytoplasm
YOL045W	YOL045W	PSK2	hom	Verified	0.422441405645878	0.336351430424211	no	1634	0.351044643128299	1149	NA	FT	SIGNALING|TRANSLATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication	regulation of (1->6)-beta-D-glucan biosynthetic process|negative regulation of glycogen biosynthetic process|protein phosphorylation	protein serine/threonine kinase activity	mitochondrion|cytoplasm
YDL146W	YDL146W	LDB17	hom	Verified	0.422114540437086	0.336470707600865	no	1635	0.322078553654026	1071	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck	endocytosis	molecular_function	cellular bud|cellular bud neck|cytoplasm|actin cortical patch
YOR233W	YOR233W	KIN4	hom	Verified	0.421793358286731	0.336587926990537	no	1636	0.311331640459307	1066	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication	mitotic cell cycle spindle orientation checkpoint|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cell cortex|spindle pole body|cellular bud neck
YJR063W	YJR063W	RPA12	hom	Verified	0.421584576735598	0.33666413291192	no	1637	0.36424760470234	1242	NA	FF|FT		NUCLEUS		RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex	termination of RNA polymerase I transcription|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	molecular_function	DNA-directed RNA polymerase I complex
YEL060C	YEL060C	PRB1	hom	Verified	0.421555728793374	0.336674663028882	no	1638	0.318861039084835	1055	NA	FT	PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS			Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress	vacuolar protein catabolic process|sporulation resulting in formation of a cellular spore|cellular response to starvation	serine-type endopeptidase activity	fungal-type vacuole lumen|fungal-type vacuole
YGL162W	YGL162W	SUT1	hom	Verified	0.421349103701199	0.33675008935735	no	1639	0.333691079007798	1125	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress	positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding	nucleus
YPL256C	YPL256C	CLN2	hom	Verified	0.420599100121276	0.337023925478653	no	1640	0.327030553643667	1082	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)	regulation of cyclin-dependent protein kinase activity|re-entry into mitotic cell cycle after pheromone arrest	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YDR210W_p	YDR210W	YDR210W	hom	Uncharacterized	0.419675514473651	0.33736125737347	no	1641	0.293333770568215	1012	NA	FT		PLASMA MEMBRANE		Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YJR053W	YJR053W	BFA1	hom	Verified	0.419664020318412	0.33736545634145	no	1642	0.313670039580356	1044	NA	FT	CELL CYCLE|CELL DIVISION	CYTOSKELETON		Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint	GTPase activator activity	spindle pole body
YMR103C_d	YMR103C	YMR103C	hom	Dubious	0.418344246154593	0.337847721984094	no	1643	0.332754797346858	1094	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR410W	YLR410W	VIP1	hom	Verified	0.418022081976994	0.337965486166158	no	1644	0.318717891942924	1079	NA	FT		CYTOSKELETON		Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1	inositol phosphate biosynthetic process	inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 4-kinase activity|inositol hexakisphosphate 6-kinase activity	cytoplasm
YLR231C	YLR231C	BNA5	hom	Verified	0.417876429427273	0.338018733336548	no	1645	0.304750919496238	1032	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p	de novo NAD biosynthetic process from tryptophan	kynureninase activity	nucleus|cytoplasm
YGR109C	YGR109C	CLB6	hom	Verified	0.417719402407855	0.33807614237788	no	1646	0.332293092105144	1113	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1	regulation of cyclin-dependent protein kinase activity|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|premeiotic DNA replication	cyclin-dependent protein kinase regulator activity	cellular_component
YIL071C	YIL071C	PCI8	hom	Verified	0.417597815566165	0.338120597085446	no	1647	0.344699751290208	1179	NA	FT		NUCLEUS		Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain	cullin deneddylation	molecular_function	signalosome
YMR145C	YMR145C	NDE1	hom	Verified	0.417185883926236	0.338271224735215	no	1648	0.340010971592213	1147	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain	glucose catabolic process to ethanol|NADH oxidation|chronological cell aging	NADH dehydrogenase activity	mitochondrion
YDR506C	YDR506C	GMC1	hom	Verified	0.41716276123845	0.338279680585556	no	1649	0.327043833824731	1096	NA	FT	CELL CYCLE|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS			Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein	meiosis|synaptonemal complex organization	molecular_function	cellular_component
YPL220W	YPL220W	RPL1A	hom	Verified	0.416248338462972	0.33861414573934	no	1650	0.327373151105074	1121	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOR345C_d	YOR345C	YOR345C	hom	Dubious	0.415551939237795	0.338868950621079	no	1651	0.331082820590684	1106	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	Unknown	Unknown	Unknown
YKL030W_d	YKL030W	YKL030W	hom	Dubious	0.415073075436706	0.339044204460931	no	1652	0.333078486594001	1075	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene MAE1	Unknown	Unknown	Unknown
YJL153C	YJL153C	INO1	hom	Verified	0.414327113149796	0.33931727998686	no	1653	0.35233082116361	1156	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM			Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element	inositol biosynthetic process	inositol-3-phosphate synthase activity	cytoplasm
YKR013W	YKR013W	PRY2	hom	Verified	0.414222360911781	0.339355633556783	no	1654	0.35870265078304	1222	NA					Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication	biological_process	molecular_function	extracellular region|fungal-type vacuole
YMR163C	YMR163C	INP2	hom	Verified	0.413529892162589	0.339609213171494	no	1655	0.3280975081825	1080	NA	FT	PEROXISOME ORGANIZATION			Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene	peroxisome inheritance	protein anchor	peroxisome|integral to peroxisomal membrane|cytoplasm
YBL029C-A	YBL029C-A	YBL029C-A	hom	Verified	0.413105683420145	0.33976459279631	no	1656	0.347304399655705	1152	NA	FT		PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica	biological_process	molecular_function	plasma membrane
YDR360W_d	YDR360W	OPI7	hom	Dubious	0.412160774073272	0.340110793037303	no	1657	0.339025081421678	1123	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.	Unknown	Unknown	Unknown
YOR346W	YOR346W	REV1	hom	Verified	0.411541514930193	0.34033775322192	no	1658	0.317111124491865	1032	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress	error-prone translesion synthesis|error-free translesion synthesis	deoxycytidyl transferase activity|DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|replication fork
YKR103W	YKR103W	NFT1	hom	Verified	0.411226796445883	0.340453120589817	no	1659	0.34508732467931	1161	NA	FT	NUCLEOTIDE METABOLISM			Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.	transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YML111W	YML111W	BUL2	hom	Verified	0.411070072951474	0.340510576795585	no	1660	0.331840336286049	1112	NA	FT			UBIQUITIN LIGASE COMPLEX	Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication	protein polyubiquitination|protein monoubiquitination	ubiquitin-ubiquitin ligase activity	ubiquitin ligase complex|cytoplasm
YNL212W	YNL212W	VID27	hom	Verified	0.410896512521396	0.340574209888967	no	1661	0.33894242606833	1119	NA					Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth	biological_process	molecular_function	cytoplasm
YKL124W	YKL124W	SSH4	hom	Verified	0.41025784915471	0.340808404430684	no	1662	0.299473508173392	1026	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT			Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|vesicle-mediated transport	molecular_function	fungal-type vacuole
YDR380W	YDR380W	ARO10	hom	Verified	0.410184410734705	0.340835337853814	no	1663	0.32855504930209	1104	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway	L-phenylalanine catabolic process|methionine catabolic process to 3-methylthiopropanol|tryptophan catabolic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway|leucine catabolic process	pyruvate decarboxylase activity|carboxy-lyase activity|phenylpyruvate decarboxylase activity	cytoplasm
YDR221W	YDR221W	GTB1	hom	Verified	0.41009417943889	0.340868431148122	no	1664	0.333335459323632	1124	NA	FT	CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM		Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress	polysaccharide biosynthetic process|protein N-linked glycosylation	alpha-glucosidase activity	glucosidase II complex|endoplasmic reticulum|endoplasmic reticulum lumen
YJR117W	YJR117W	STE24	hom	Verified	0.409968556006652	0.340914506926817	no	1665	0.326802914841583	1098	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans	CAAX-box protein processing|peptide pheromone maturation	metalloendopeptidase activity	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|integral to membrane|nuclear inner membrane
YLR335W	YLR335W	NUP2	hom	Verified	0.40956603016413	0.341062160106578	no	1666	0.356054617945438	1199	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CHROMOSOME	NUCLEAR PORE	Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization	rRNA export from nucleus|snRNA export from nucleus|nuclear pore organization|tRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA-binding (hnRNP) protein import into nucleus|ribosomal protein import into nucleus|snRNP protein import into nucleus|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|protein targeting to membrane|poly(A)+ mRNA export from nucleus|protein export from nucleus|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, non-stop decay	nucleocytoplasmic transporter activity	nuclear chromatin|mitochondrion|integral to membrane|nuclear pore
YHL046C	YHL046C	PAU13	hom	Verified	0.4086014103755	0.341416097736765	no	1667	0.326182755429557	1074	NA					Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock	biological_process	molecular_function	cellular_component
YER084W_p	YER084W	YER084W	hom	Uncharacterized	0.40775838652983	0.341725533732446	no	1668	0.34566988415786	1163	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YIR025W	YIR025W	MND2	hom	Verified	0.407153741405559	0.341947537187829	no	1669	0.350259398818267	1149	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CHROMOSOME SEGREGATION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|reciprocal meiotic recombination|regulation of mitotic metaphase/anaphase transition|protein ubiquitination|mitotic sister chromatid segregation	molecular_function	nucleus|anaphase-promoting complex
YER053C	YER053C	PIC2	hom	Verified	0.406969631696705	0.342015146361631	no	1670	0.307123410366141	1018	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature	phosphate ion transport|transmembrane transport	inorganic phosphate transmembrane transporter activity	mitochondrion|integral to membrane
YGL260W_p	YGL260W	YGL260W	hom	Uncharacterized	0.406600908831687	0.342150564816838	no	1671	0.33366224652205	1145	NA					Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium	biological_process	molecular_function	cellular_component
YKL018C-A_p	YKL018C-A	YKL018C-A	hom	Uncharacterized	0.406538575701078	0.342173459508189	no	1672	0.323662074521388	1119	NA					Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YOR087W	YOR087W	YVC1	hom	Verified	0.405618327198311	0.342511530303872	no	1673	0.339627198907203	1107	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock	cellular cation homeostasis	voltage-gated ion channel activity|calcium activated cation channel activity|sodium channel activity|calcium channel activity|potassium channel activity	fungal-type vacuole membrane|fungal-type vacuole
YPL030W	YPL030W	TRM44	hom	Verified	0.404890360266047	0.342779052230381	no	1674	0.331685951305721	1139	NA	FT	RNA PROCESSING			tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene	tRNA methylation	tRNA (uracil) methyltransferase activity	cytoplasm
YGL217C_d	YGL217C	YGL217C	hom	Dubious	0.403888958772669	0.34314718796884	no	1675	0.330496797344492	1113	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W	Unknown	Unknown	Unknown
YNL034W_p	YNL034W	YNL034W	hom	Uncharacterized	0.403605847595855	0.343251292463665	no	1676	0.341640338507518	1128	NA					Putative protein of unknown function; YNL034W is not an essential gene	biological_process	molecular_function	cellular_component
YGR012W	YGR012W	YGR012W	hom	Verified	0.40347847199342	0.343298134384673	no	1677	0.333321853365401	1099	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Putative cysteine synthase, localized to the mitochondrial outer membrane	cysteine biosynthetic process	cysteine synthase activity	mitochondrial outer membrane|mitochondrion
YLR284C	YLR284C	ECI1	hom	Verified	0.403190964305407	0.34340387315455	no	1678	0.340321642861054	1134	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced	fatty acid beta-oxidation	dodecenoyl-CoA delta-isomerase activity	peroxisome
YKL120W	YKL120W	OAC1	hom	Verified	0.403112325991254	0.343432796668048	no	1679	0.337443324793938	1140	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family	sulfate transport|oxaloacetate transport|isopropylmalate transport	secondary active sulfate transmembrane transporter activity|oxaloacetate secondary active transmembrane transporter activity|isopropylmalate transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YOR118W	YOR118W	RTC5	hom	Verified	0.40208595445475	0.343810384601436	no	1680	0.361958977813934	1207	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity	biological_process	molecular_function	cytoplasm
YDR399W	YDR399W	HPT1	hom	Verified	0.401785275143014	0.343921029906126	no	1681	0.336490763241746	1143	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome	GMP salvage|IMP salvage	hypoxanthine phosphoribosyltransferase activity	nucleus|cytoplasm
YHR120W	YHR120W	MSH1	hom	Verified	0.401754572611973	0.343932328711787	no	1682	0.322161589239078	1114	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	MITOCHONDRION		DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis	DNA repair|mismatch repair|mitochondrial DNA repair|mitochondrion organization|reciprocal meiotic recombination|mitochondrial genome maintenance	guanine/thymine mispair binding|dinucleotide insertion or deletion binding|DNA-dependent ATPase activity	mitochondrion
YDR283C	YDR283C	GCN2	hom	Verified	0.401382238998856	0.344069361897984	no	1683	0.386746789066276	1282	NA	FF|FT	KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION		RIBOSOME	Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control	cellular amino acid biosynthetic process|protein phosphorylation|regulation of translational initiation|DNA damage checkpoint	protein homodimerization activity|protein kinase activity|eukaryotic translation initiation factor 2alpha kinase activity	cytosolic ribosome
YNL218W	YNL218W	MGS1	hom	Verified	0.401109789069106	0.344169646998576	no	1684	0.312428484872504	1052	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress	regulation of DNA repair|DNA replication, Okazaki fragment processing|DNA strand renaturation	ubiquitin binding|single-stranded DNA-dependent ATPase activity|enzyme activator activity	nucleus|cytoplasm
YJR129C_p	YJR129C	YJR129C	hom	Uncharacterized	0.400919063811133	0.344239856884973	no	1685	0.33290223741493	1137	NA					Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cytoplasm
YPL212C	YPL212C	PUS1	hom	Verified	0.400779771550162	0.344291136620797	no	1686	0.329076971871819	1097	NA	FT	RNA PROCESSING	NUCLEUS		tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA	snRNA pseudouridine synthesis|tRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus
YEL010W_d	YEL010W	YEL010W	hom	Dubious	0.400538837865201	0.344379841886693	no	1687	0.305983901863816	1058	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNR063W_p	YNR063W	YNR063W	hom	Uncharacterized	0.400353211580201	0.34444819030271	no	1688	0.330352733966486	1116	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc-cluster protein of unknown function	biological_process	sequence-specific DNA binding	cellular_component
YNL246W	YNL246W	VPS75	hom	Verified	0.399018651860447	0.344939730490055	no	1689	0.362681753860458	1194	NA	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress	double-strand break repair via nonhomologous end joining|nucleosome assembly|positive regulation of histone acetylation	histone binding|acetyltransferase activator activity	chromatin|nucleus
YER093C-A	YER093C-A	AIM11	hom	Verified	0.39874086459553	0.345042077031488	no	1690	0.343687544998347	1163	NA					Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YCL037C	YCL037C	SRO9	hom	Verified	0.398409076256615	0.345164334313315	no	1691	0.36633336195121	1244	NA	FT	TRANSLATION			Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication	cytoplasmic translation	RNA binding	polysome
YLR285C-A_p	YLR285C-A	YLR285C-A	hom	Uncharacterized	0.3978719391886	0.345362292698818	no	1692	0.334266915598077	1118	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YLR217W_d	YLR217W	YLR217W	hom	Dubious	0.397582597251116	0.345468945332294	no	1693	0.355462874017027	1198	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6	Unknown	Unknown	Unknown
YDR286C_p	YDR286C	YDR286C	hom	Uncharacterized	0.397368799583257	0.345547759919003	no	1694	0.328470835523851	1109	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site	biological_process	molecular_function	cellular_component
YJL135W_d	YJL135W	YJL135W	hom	Dubious	0.3969026032047	0.345719642235303	no	1695	0.335079555801389	1099	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3	Unknown	Unknown	Unknown
YGL041C-B_p	YGL041C-B	YGL041C-B	hom	Uncharacterized	0.396835375260227	0.345744431184843	no	1696	0.336407064065759	1127	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YBR017C	YBR017C	KAP104	hom	Verified	0.396747136571206	0.345776968426616	no	1697	0.32714938093821	1072	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE	SITE OF POLARIZED GROWTH		Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis	protein import into nucleus|cell cycle|mRNA-binding (hnRNP) protein import into nucleus|transcription factor import into nucleus	nuclear localization sequence binding	cytosol|integral to membrane|cellular bud neck|cellular bud tip
YNL279W	YNL279W	PRM1	hom	Verified	0.396462307812786	0.345882004302108	no	1698	0.351027223030115	1172	NA	FT	MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p	plasma membrane fusion involved in cytogamy|response to pheromone	molecular_function	integral to membrane|mating projection tip
YPR200C	YPR200C	ARR2	hom	Verified	0.396283795574379	0.345947840040595	no	1699	0.338043172092589	1140	NA					Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p	response to arsenic-containing substance	arsenate reductase activity	cellular_component
YER048C	YER048C	CAJ1	hom	Verified	0.394973164776856	0.346431346311387	no	1700	0.336106769332867	1114	NA	FT		NUCLEUS		Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly	protein folding	chaperone binding	nucleus
YIL002W-A_p	YIL002W-A	YIL002W-A	hom	Uncharacterized	0.394134751496435	0.346740777638059	no	1701	0.324951820293291	1101	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YDR357C_p	YDR357C	CNL1	hom	Uncharacterized	0.392722460573092	0.347262239841777	no	1702	0.340732236635165	1128	NA					Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	BLOC-1 complex|cytoplasm
YPR063C_p	YPR063C	YPR063C	hom	Uncharacterized	0.392625378920758	0.347298096076521	no	1703	0.35104762480527	1167	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER-localized protein of unknown function	biological_process	molecular_function	endoplasmic reticulum
YDL076C	YDL076C	RXT3	hom	Verified	0.390873076616503	0.347945527860091	no	1704	0.355406588965711	1186	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase I promoter	molecular_function	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YPL070W	YPL070W	MUK1	hom	Verified	0.39015615310754	0.348210541095395	no	1705	0.341512504739621	1132	NA					Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation	biological_process	molecular_function	cytoplasm
YDR423C	YDR423C	CAD1	hom	Verified	0.388640923147721	0.348770894839372	no	1706	0.359914852694111	1200	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication	cellular response to cadmium ion|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YJR126C	YJR126C	VPS70	hom	Verified	0.388323504840477	0.34888832252858	no	1707	0.338852796394571	1140	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Protein of unknown function involved in vacuolar protein sorting	protein targeting to vacuole	molecular_function	cellular_component
YHR143W	YHR143W	DSE2	hom	Verified	0.38826253169384	0.348910880968704	no	1708	0.414766906152484	1367	NA	FF|FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION			Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP	cytokinesis, completion of separation|pseudohyphal growth	glucosidase activity	extracellular region|fungal-type cell wall
YGL010W_p	YGL010W	YGL010W	hom	Uncharacterized	0.387983194743958	0.349014235026122	no	1709	0.350793231585985	1153	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; YGL010W is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YDL037C	YDL037C	BSC1	hom	Verified	0.386355367347666	0.349616750209607	no	1710	0.343627362672456	1168	NA					Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression	biological_process	molecular_function	cellular_component
YNR037C	YNR037C	RSM19	hom	Verified	0.385415832829423	0.349964677021349	no	1711	0.364970688649128	1233	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YFL028C	YFL028C	CAF16	hom	Verified	0.385212805659224	0.350039878261069	no	1712	0.340775525799262	1135	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator	regulation of transcription from RNA polymerase II promoter	ATPase activity	CCR4-NOT complex|cytoplasm
YDL009C_p	YDL009C	YDL009C	hom	Uncharacterized	0.38482405586817	0.350183887548196	no	1713	0.348266826022548	1152	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene	biological_process	molecular_function	cellular_component
YML059C	YML059C	NTE1	hom	Verified	0.384440396744929	0.350326032161832	no	1714	0.351004645233112	1163	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes	phosphatidylcholine catabolic process|regulation of phospholipid biosynthetic process	lysophospholipase activity|carboxylesterase activity	integral to membrane|endoplasmic reticulum
YBL057C	YBL057C	PTH2	hom	Verified	0.384395066040533	0.350342828444207	no	1715	0.369338682035601	1240	NA	FT	PROTEOLYSIS	MITOCHONDRION		One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	aminoacyl-tRNA hydrolase activity	mitochondrial outer membrane|mitochondrion|cytoplasm
YGR061C	YGR061C	ADE6	hom	Verified	0.382514692533228	0.351039816468691	no	1716	0.336020262422823	1123	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway	'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process	phosphoribosylformylglycinamidine synthase activity	cytoplasm
YDR036C	YDR036C	EHD3	hom	Verified	0.381374058733143	0.351462853626767	no	1717	0.342241150237311	1126	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis	fatty acid beta-oxidation|biological_process	3-hydroxyisobutyryl-CoA hydrolase activity	mitochondrion
YDR411C	YDR411C	DFM1	hom	Verified	0.380790039775407	0.351679525289927	no	1718	0.336168360347289	1108	NA	FT	SIGNALING|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p	endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process	molecular_function	Doa10p ubiquitin ligase complex|integral to membrane|endoplasmic reticulum|Hrd1p ubiquitin ligase ERAD-L complex
YBR205W	YBR205W	KTR3	hom	Verified	0.380261377057674	0.351875701285582	no	1719	0.326629178274194	1085	NA	FT	CARBOHYDRATE METABOLISM			Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress	N-glycan processing|protein O-linked glycosylation	mannosyltransferase activity	fungal-type vacuole
YER072W	YER072W	VTC1	hom	Verified	0.379757600642654	0.352062679180447	no	1720	0.355925572671206	1169	NA	FT	MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress	polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic	mRNA binding	integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex|intrinsic to vacuolar membrane
YHL031C	YHL031C	GOS1	hom	Verified	0.378674105805076	0.35246494219898	no	1721	0.42939853331116	1426	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28	Golgi vesicle transport|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|Golgi medial cisterna
YDR084C	YDR084C	TVP23	hom	Verified	0.37860776812029	0.352489576384185	no	1722	0.319704255079042	1090	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|cytoplasm
YCL045C	YCL045C	EMC1	hom	Verified	0.378358596423789	0.352582110639895	no	1723	0.347475582851391	1130	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YIR038C	YIR038C	GTT1	hom	Verified	0.378017699679498	0.352708722723687	no	1724	0.347341374507756	1179	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p	glutathione metabolic process	glutathione transferase activity|glutathione peroxidase activity	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum|plasma membrane
YDR536W	YDR536W	STL1	hom	Verified	0.377682414572831	0.352833266511635	no	1725	0.339831997816623	1150	NA	FT		PLASMA MEMBRANE		Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock	transport|glycerol transport|transmembrane transport	solute:hydrogen symporter activity|transporter activity	integral to membrane|plasma membrane|membrane
YDR191W	YDR191W	HST4	hom	Verified	0.377375042062875	0.352947455845322	no	1726	0.353692404374381	1195	NA	FT	KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism	short-chain fatty acid metabolic process|chromatin silencing at telomere|histone deacetylation	histone deacetylase activity|DNA binding	nucleus|cytoplasm
YEL044W	YEL044W	IES6	hom	Verified	0.377131737083906	0.353037853391105	no	1727	0.373660185335814	1253	NA	FT		NUCLEUS		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes	biological_process	molecular_function	nucleus
YMR320W_d	YMR320W	YMR320W	hom	Dubious	0.375311384356207	0.353714450230218	no	1728	0.347009118831375	1182	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAR031W	YAR031W	PRM9	hom	Verified	0.374658951464731	0.353957062070008	no	1729	0.352943009232738	1171	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family	vesicle organization	molecular_function	integral to membrane|endoplasmic reticulum|plasma membrane
YPR044C_d	YPR044C	OPI11	hom	Dubious	0.373122229768467	0.354528737244308	no	1730	0.355938136919021	1183	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YCR069W	YCR069W	CPR4	hom	Verified	0.372961068047791	0.354588709962801	no	1731	0.335364595351323	1143	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	membrane
YJR038C_d	YJR038C	YJR038C	hom	Dubious	0.372867475518515	0.354623539977427	no	1732	0.349816819428853	1188	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML072C	YML072C	TCB3	hom	Verified	0.372673375393383	0.35469577728987	no	1733	0.357842001004043	1208	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact	biological_process	lipid binding	mitochondrion|cortical endoplasmic reticulum|cellular bud
YDL229W	YDL229W	SSB1	hom	Verified	0.372333572858571	0.354822252549433	no	1734	0.336615245239862	1130	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS			Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication	cytoplasmic translation|cellular response to glucose starvation|translational termination|ribosomal subunit export from nucleus|regulation of translational fidelity|rRNA processing|'de novo' cotranslational protein folding	unfolded protein binding|ATPase activity|calmodulin binding	plasma membrane|polysome|cytoplasm
YNL159C	YNL159C	ASI2	hom	Verified	0.372200180715233	0.354871905776694	no	1735	0.322416804786469	1102	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS		Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals	ubiquitin-dependent protein catabolic process	molecular_function	nuclear inner membrane
YHR050W-A_p	YHR050W-A	YHR050W-A	hom	Uncharacterized	0.371799447215805	0.355021087643861	no	1736	0.35806604338384	1199	NA					Protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YOL017W	YOL017W	ESC8	hom	Verified	0.371495181816311	0.355134371984327	no	1737	0.368854722736978	1223	NA	FT	GENE SILENCING	NUCLEUS		Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication	chromatin silencing	molecular_function	nucleus
YMR316C-B_d	YMR316C-B	YMR316C-B	hom	Dubious	0.371115585164847	0.355275721670396	no	1738	0.317055625756432	1059	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR057W	YKR057W	RPS21A	hom	Verified	0.371106866730844	0.355278968371158	no	1739	0.345205153666148	1165	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YIL069C	YIL069C	RPS24B	hom	Verified	0.370898211642405	0.355356673605206	no	1740	0.340103735085894	1125	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YOR248W_d	YOR248W	YOR248W	hom	Dubious	0.370848837797927	0.355375061796867	no	1741	0.352733747347491	1166	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR228C	YLR228C	ECM22	hom	Verified	0.370442385976505	0.355526448540337	no	1742	0.33347510718958	1131	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication	positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|membrane|perinuclear region of cytoplasm
YER086W	YER086W	ILV1	hom	Verified	0.370031719514725	0.355679428216897	no	1743	0.388136586342545	1295	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation	threonine catabolic process|isoleucine biosynthetic process	L-threonine ammonia-lyase activity	mitochondrion
YOL008W	YOL008W	COQ10	hom	Verified	0.369868613251189	0.355740194301541	no	1744	0.343438511001424	1154	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes	cellular respiration	ubiquinone binding	mitochondrion|mitochondrial inner membrane
YJL080C	YJL080C	SCP160	hom	Verified	0.369837884560487	0.355751642845109	no	1745	0.340556458569083	1177	NA	FT	CELL CYCLE|SIGNALING|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins	meiotic telomere clustering|pheromone-dependent signal transduction involved in conjugation with cellular fusion|chromosome segregation|intracellular mRNA localization|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	G-protein alpha-subunit binding|RNA binding	endoplasmic reticulum membrane|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YBR066C	YBR066C	NRG2	hom	Verified	0.369255510804897	0.355968641576426	no	1746	0.308384360613579	1040	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter by glucose|biofilm formation|pseudohyphal growth|Unknown	sequence-specific DNA binding	nucleus
YLR438W	YLR438W	CAR2	hom	Verified	0.368807865412816	0.356135470795623	no	1747	0.35934561263956	1202	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress	ornithine metabolic process|arginine catabolic process	ornithine-oxo-acid transaminase activity	cytosol|nucleus|cytoplasm
YOR265W	YOR265W	RBL2	hom	Verified	0.368747208780058	0.356158078528746	no	1748	0.371362928493083	1241	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress	tubulin complex assembly|tubulin complex biogenesis	tubulin binding|beta-tubulin binding	cytoplasm
YHL024W	YHL024W	RIM4	hom	Verified	0.368721003367472	0.356167845877107	no	1749	0.371781058749053	1246	NA	FT	CELL CYCLE			Putative RNA-binding protein required for the expression of early and middle sporulation genes	meiosis|reciprocal meiotic recombination|sporulation resulting in formation of a cellular spore|premeiotic DNA replication	RNA binding	cytoplasm
YBR178W_d	YBR178W	YBR178W	hom	Dubious	0.368485169203091	0.356255750835441	no	1750	0.36209686563443	1233	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C	Unknown	Unknown	Unknown
YOR080W	YOR080W	DIA2	hom	Verified	0.368196693018331	0.356363287997035	no	1751	0.363190024317252	1220	NA	FT	CELL CYCLE|PROTEOLYSIS	NUCLEUS|CHROMOSOME	UBIQUITIN LIGASE COMPLEX	Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA replication|invasive growth in response to glucose limitation|protein ubiquitination	ubiquitin-protein ligase activity|DNA replication origin binding	SCF ubiquitin ligase complex|nucleus|nuclear replication fork
YER152C	YER152C	YER152C	hom	Verified	0.367907710516921	0.356471025354469	no	1752	0.331869485309418	1103	NA	FT		NUCLEUS		Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene	biological_process	2-aminoadipate transaminase activity	nucleus|cytoplasm
YGR268C	YGR268C	HUA1	hom	Verified	0.367621712392176	0.356577661366255	no	1753	0.36672819769464	1227	NA					Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly	biological_process	molecular_function	cytoplasm
YDR149C_d	YDR149C	YDR149C	hom	Dubious	0.367133084369433	0.356759875014869	no	1754	0.35579737083565	1200	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth	Unknown	Unknown	Unknown
YIL066C	YIL066C	RNR3	hom	Verified	0.366890112005424	0.356850493698835	no	1755	0.357575193477937	1204	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM	MITOCHONDRION		Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits	deoxyribonucleotide biosynthetic process	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	mitochondrion|ribonucleoside-diphosphate reductase complex|cytoplasm
YOL150C_d	YOL150C	YOL150C	hom	Dubious	0.366226275578377	0.35709811851695	no	1756	0.350123982265381	1165	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL173W	YIL173W	VTH1	hom	Verified	0.36587020430227	0.357230965336244	no	1757	0.341580461492666	1122	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting	Golgi to vacuole transport	signal sequence binding	endosome|integral to membrane
YHL003C	YHL003C	LAG1	hom	Verified	0.364404261643452	0.357778076801563	no	1758	0.338939845245814	1115	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress	replicative cell aging|ceramide biosynthetic process	sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YKR102W	YKR102W	FLO10	hom	Verified	0.364213459269806	0.357849308590457	no	1759	0.347424943484117	1160	NA					Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth	filamentous growth of a population of unicellular organisms|flocculation via cell wall protein-carbohydrate interaction|flocculation|invasive growth in response to glucose limitation	mannose binding	fungal-type cell wall
YLR211C_p	YLR211C	YLR211C	hom	Uncharacterized	0.364191053199635	0.3578576737193	no	1760	0.3490685160192	1176	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron	biological_process	molecular_function	cytoplasm
YNL004W	YNL004W	HRB1	hom	Verified	0.363995444229353	0.357930705677976	no	1761	0.374048054429107	1238	NA	FT	RNA LOCALIZATION	NUCLEUS		Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication	poly(A)+ mRNA export from nucleus	RNA binding	integral to membrane|nucleus|cytoplasm
YDL122W	YDL122W	UBP1	hom	Verified	0.363775761528597	0.358012731929376	no	1762	0.348683382891706	1155	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains	protein deubiquitination	ubiquitin-specific protease activity	endoplasmic reticulum|cytoplasm
YKR021W	YKR021W	ALY1	hom	Verified	0.362837841933393	0.35836301084707	no	1763	0.357257725610479	1170	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication	Unknown|regulation of intracellular transport|ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	late endosome|cytoplasm|early endosome
YHR077C	YHR077C	NMD2	hom	Verified	0.362793986552819	0.358379392159322	no	1764	0.358970824819998	1215	NA					Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|translational frameshifting	molecular_function	polysome|cytoplasm
YPL164C	YPL164C	MLH3	hom	Verified	0.362705100429661	0.358412594616556	no	1765	0.359480597834699	1187	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability	mismatch repair|reciprocal meiotic recombination	molecular_function	nucleus|MutLbeta complex
YGR173W	YGR173W	RBG2	hom	Verified	0.360856319340728	0.359103429285776	no	1766	0.354318602829869	1177	NA	FT	TRANSLATION			Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein	cytoplasmic translation	GTP binding	cytoplasm
YEL062W	YEL062W	NPR2	hom	Verified	0.360510474104385	0.359232712646134	no	1767	0.372432008986055	1216	NA	FT	SIGNALING|RESPONSE TO NUTRIENT LEVELS			Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline	proline transport|urea transport|regulation of TOR signaling cascade|cellular response to amino acid starvation|response to drug|cellular response to nitrogen starvation	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YKL065C	YKL065C	YET1	hom	Verified	0.360056320590661	0.359402508129358	no	1768	0.343209180329848	1161	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein	biological_process	molecular_function	ribosome|integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YKL026C	YKL026C	GPX1	hom	Verified	0.359569502326556	0.359584546896685	no	1769	0.364485741749837	1194	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress	cellular response to oxidative stress|peroxisome organization	phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity	extrinsic to mitochondrial outer membrane|peroxisomal matrix
YLR431C	YLR431C	ATG23	hom	Verified	0.359032374573722	0.359785435158347	no	1770	0.369779898753646	1228	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p	protein localization to pre-autophagosomal structure|positive regulation of macroautophagy|CVT pathway	molecular_function	pre-autophagosomal structure|extrinsic to membrane
YDL239C	YDL239C	ADY3	hom	Verified	0.358859844046659	0.359849970596414	no	1771	0.360972763503538	1178	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION	NUCLEUS|CYTOSKELETON		Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication	mitochondrion inheritance|ascospore wall assembly|sporulation resulting in formation of a cellular spore	molecular_function	spindle pole body|prospore membrane
YNR045W	YNR045W	PET494	hom	Verified	0.358565161276701	0.359960206600093	no	1772	0.337731973955141	1147	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrion|mitochondrial inner membrane
YGR132C	YGR132C	PHB1	hom	Verified	0.35850793421883	0.359981615657266	no	1773	0.34298358120664	1141	NA	FT	MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation	mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging|mitochondrion morphogenesis|inner mitochondrial membrane organization	molecular_function	mitochondrion|mitochondrial inner membrane
YGL243W	YGL243W	TAD1	hom	Verified	0.358206104263478	0.360094539697676	no	1774	0.349690840887671	1161	NA	FT	RNA PROCESSING	NUCLEUS		tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala	tRNA modification	tRNA-specific adenosine-37 deaminase activity	nucleus
YLR408C_p	YLR408C	BLS1	hom	Uncharacterized	0.357394607345591	0.360398206630316	no	1775	0.342425806171673	1131	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene	biological_process	molecular_function	endosome|BLOC-1 complex
YDL079C	YDL079C	MRK1	hom	Verified	0.357274750620739	0.360443065193503	no	1776	0.356240867606049	1170	NA	FT	PROTEIN PHOSPHORYLATION			Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation	regulation of protein catabolic process|protein phosphorylation|response to stress	protein serine/threonine kinase activity	cellular_component
YNL202W	YNL202W	SPS19	hom	Verified	0.35669391790209	0.360660479622401	no	1777	0.378123377046282	1277	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate	fatty acid catabolic process|ascospore formation	2,4-dienoyl-CoA reductase (NADPH) activity	peroxisomal matrix
YDR485C	YDR485C	VPS72	hom	Verified	0.35668565018878	0.360663574677264	no	1778	0.400917994474474	1325	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting	chromatin remodeling|histone exchange	histone binding	Swr1 complex|nucleus|cytoplasm
YLR040C_p	YLR040C	YLR040C	hom	Uncharacterized	0.356226219831608	0.360835578793896	no	1779	0.364004419338747	1186	NA					Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential	biological_process	molecular_function	fungal-type cell wall
YJL066C	YJL066C	MPM1	hom	Verified	0.355678885744025	0.361040529547788	no	1780	0.370451792420956	1196	NA	FT		MITOCHONDRION		Mitochondrial intermembrane space protein of unknown function	biological_process	molecular_function	mitochondrion|extrinsic to membrane
YFL040W_p	YFL040W	YFL040W	hom	Uncharacterized	0.354383975154439	0.361525571155518	no	1781	0.359800798137097	1185	NA					Putative transporter, member of the sugar porter family; YFL040W is not an essential gene	transmembrane transport	substrate-specific transmembrane transporter activity	integral to membrane|membrane
YML029W	YML029W	USA1	hom	Verified	0.354326919100107	0.361546948074103	no	1782	0.349822827890823	1159	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p	ER-associated protein catabolic process|mRNA splicing, via spliceosome|positive regulation of protein oligomerization	protein complex scaffold	Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YPL272C_p	YPL272C	YPL272C	hom	Uncharacterized	0.352654666359226	0.362173674697116	no	1783	0.388162719129855	1286	NA					Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene	biological_process	molecular_function	cellular_component
YML107C	YML107C	PML39	hom	Verified	0.352117744992581	0.362374980486106	no	1784	0.346239045036166	1145	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes	maintenance of RNA location	molecular_function	ribosome|nuclear pore
YIL002C	YIL002C	INP51	hom	Verified	0.351844719303671	0.362477359521536	no	1785	0.39366004341027	1308	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	CYTOSKELETON		Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth	phosphatidylinositol dephosphorylation	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	membrane|cytoplasm
YPL208W	YPL208W	RKM1	hom	Verified	0.351388398456722	0.362648492435766	no	1786	0.362871410555288	1212	NA	FT		NUCLEUS		SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)	peptidyl-lysine dimethylation	protein-lysine N-methyltransferase activity	nucleus|cytoplasm
YLR209C	YLR209C	PNP1	hom	Verified	0.351231776183813	0.362707236439202	no	1787	0.372146614405462	1238	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway	guanosine catabolic process|inosine catabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinate nucleotide salvage	nicotinamide riboside hydrolase activity|inosine nucleosidase activity|purine-nucleoside phosphorylase activity	intracellular
YNL077W	YNL077W	APJ1	hom	Verified	0.351017938163359	0.362787445456775	no	1788	0.38224194531258	1276	NA	FT		NUCLEUS|MITOCHONDRION		Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress	biological_process	unfolded protein binding	mitochondrion|nucleus|cytoplasm
YMR011W	YMR011W	HXT2	hom	Verified	0.350560954452222	0.362958876754257	no	1789	0.361586086540245	1215	NA	FT		PLASMA MEMBRANE		High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose	glucose transport	pentose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YMR250W	YMR250W	GAD1	hom	Verified	0.350558627394489	0.362959749789004	no	1790	0.368958439105841	1242	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS			Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress	cellular response to oxidative stress|glutamate catabolic process	calmodulin binding|glutamate decarboxylase activity	cytoplasm
YGR295C	YGR295C	COS6	hom	Verified	0.350151420287342	0.36311253132904	no	1791	0.352898669752908	1163	NA					Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YGR067C_p	YGR067C	YGR067C	hom	Uncharacterized	0.350076122037145	0.363140785145291	no	1792	0.351274955946739	1180	NA	FT		NUCLEUS		Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p	biological_process	sequence-specific DNA binding	cellular_component
YPL207W	YPL207W	TYW1	hom	Verified	0.350050406533536	0.363150434426105	no	1793	0.360276671742098	1219	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM		Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron	wybutosine biosynthetic process	molecular_function	endoplasmic reticulum
YBL051C	YBL051C	PIN4	hom	Verified	0.349012751708518	0.363539868165953	no	1794	0.373218171780895	1257	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE			Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage	G2/M transition of mitotic cell cycle|DNA damage checkpoint	molecular_function	cytoplasm
YBR012C_d	YBR012C	YBR012C	hom	Dubious	0.348557000946128	0.363710956859987	no	1795	0.36123039205773	1183	NA					Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p	Unknown	Unknown	Unknown
YOR065W	YOR065W	CYT1	hom	Verified	0.348298529472014	0.363807999051389	no	1796	0.34983508497715	1153	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex	oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c	electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity	mitochondrion|mitochondrial respiratory chain|integral to membrane|mitochondrial inner membrane|mitochondrial respiratory chain complex III
YJL042W	YJL042W	MHP1	hom	Verified	0.348043271129556	0.363903843458416	no	1797	0.355111543516567	1185	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins	fungal-type cell wall organization|negative regulation of microtubule depolymerization	structural constituent of cytoskeleton	microtubule
YNL073W	YNL073W	MSK1	hom	Verified	0.347912151840449	0.363953079442257	no	1798	0.365833829721689	1213	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION	MITOCHONDRION		Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)	tRNA import into mitochondrion|lysyl-tRNA aminoacylation|mitochondrial lysyl-tRNA aminoacylation|mitochondrial translation	lysine-tRNA ligase activity	mitochondrion
YOL097W-A_p	YOL097W-A	YOL097W-A	hom	Uncharacterized	0.347893059401718	0.363960248940944	no	1799	0.367370613143371	1209	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YOR037W	YOR037W	CYC2	hom	Verified	0.347861290314055	0.363972178818032	no	1800	0.333198609448474	1111	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)	cytochrome c-heme linkage|mitochondrial membrane organization	oxidoreductase activity	extrinsic to mitochondrial inner membrane|mitochondrion
YAL028W	YAL028W	FRT2	hom	Verified	0.347620016341863	0.364062785936981	no	1801	0.329480960776945	1103	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication	response to stress	molecular_function	endoplasmic reticulum
YGR107W_d	YGR107W	YGR107W	hom	Dubious	0.347563257350003	0.364084102099408	no	1802	0.372145656255422	1263	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR199W	YBR199W	KTR4	hom	Verified	0.347181059422829	0.364227649652626	no	1803	0.332645644561025	1128	NA	FT	CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family	protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YLR144C	YLR144C	ACF2	hom	Verified	0.347098203496016	0.364258771553598	no	1804	0.360311421229101	1208	NA	FT	CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION			Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress	actin cytoskeleton organization	glucan endo-1,3-beta-D-glucosidase activity	intracellular
YDR114C_p	YDR114C	YDR114C	hom	Uncharacterized	0.346907202374968	0.36433051778469	no	1805	0.377785819563613	1254	NA					Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium	biological_process	molecular_function	cellular_component
YGL241W	YGL241W	KAP114	hom	Verified	0.346623661048524	0.364437033892032	no	1806	0.356901652266001	1180	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress	protein import into nucleus|transcription factor import into nucleus	protein transporter activity	integral to membrane|nucleus|cytoplasm
YNL136W	YNL136W	EAF7	hom	Verified	0.346584464519364	0.364451759418462	no	1807	0.375308106808078	1253	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A	DNA repair|histone acetylation|regulation of transcription from RNA polymerase II promoter	molecular_function	histone acetyltransferase complex|nucleus|NuA4 histone acetyltransferase complex
YKL015W	YKL015W	PUT3	hom	Verified	0.346176751421972	0.364604942747377	no	1808	0.353828740249444	1177	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YIL065C	YIL065C	FIS1	hom	Verified	0.345886071980711	0.364714168151891	no	1809	0.358694979274621	1189	NA	FT	MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	MITOCHONDRION		Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation	peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization	molecular_function	mitochondrial outer membrane|mitochondrion|peroxisome
YKL166C	YKL166C	TPK3	hom	Verified	0.345203779535613	0.364970588779555	no	1810	0.348268356862076	1144	NA	FT	SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication	protein phosphorylation|mitochondrion organization|Ras protein signal transduction	cAMP-dependent protein kinase activity|protein kinase activity	cAMP-dependent protein kinase complex|nucleus|cytoplasm
YBL054W	YBL054W	TOD6	hom	Verified	0.344531256112986	0.36522339710327	no	1811	0.351416307991464	1194	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	Rpd3L-Expanded complex|nucleus|Rpd3L complex|cytoplasm
YPL127C	YPL127C	HHO1	hom	Verified	0.343432899801028	0.36563640621991	no	1812	0.360687880619563	1205	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination	negative regulation of DNA recombination|negative regulation of chromatin silencing|regulation of transcription, DNA-dependent	DNA binding	nucleus|nuclear nucleosome
YLR173W_p	YLR173W	YLR173W	hom	Uncharacterized	0.34262779944866	0.365939242843361	no	1813	0.370457044500982	1217	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL046C	YPL046C	ELC1	hom	Verified	0.341707262557876	0.366285603018679	no	1814	0.341668856257352	1142	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair	global genome nucleotide-excision repair|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	elongin complex|Cul3-RING ubiquitin ligase complex
YDR070C	YDR070C	FMP16	hom	Verified	0.340880812677159	0.366596654958289	no	1815	0.357588106740931	1183	NA	FT		MITOCHONDRION		Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrion
YOR308C	YOR308C	SNU66	hom	Verified	0.340627352164397	0.366692067767203	no	1816	0.365653039936911	1221	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1	maturation of 5S rRNA|mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YCL009C	YCL009C	ILV6	hom	Verified	0.340575685938948	0.366711518039266	no	1817	0.357889803890095	1169	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria	branched-chain amino acid biosynthetic process	enzyme regulator activity|acetolactate synthase activity	mitochondrial nucleoid|acetolactate synthase complex|mitochondrion
YBR085C-A	YBR085C-A	YBR085C-A	hom	Verified	0.340296639499706	0.366816573802789	no	1818	0.357549161759213	1225	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YHR126C_p	YHR126C	ANS1	hom	Uncharacterized	0.340030354941233	0.366916834259535	no	1819	0.367974387525126	1200	NA	FT		PLASMA MEMBRANE		Putative GPI protein; transcription dependent upon Azf1p	biological_process	molecular_function	cellular_component
YPL019C	YPL019C	VTC3	hom	Verified	0.340008432177446	0.36692508894036	no	1820	0.348848945707127	1175	NA	FT	MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion	polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane|integral to membrane|vacuolar transporter chaperone complex|endoplasmic reticulum
YDR321W	YDR321W	ASP1	hom	Verified	0.339894042427517	0.366968161646179	no	1821	0.358031197346867	1205	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively	asparagine catabolic process	asparaginase activity	intracellular
YAL054C	YAL054C	ACS1	hom	Verified	0.339561976311747	0.367093208437213	no	1822	0.359164898431614	1185	NA	FT	KETONE METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions	acetate fermentation|histone acetylation|acetyl-CoA biosynthetic process	acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity	cytosol|mitochondrion|integral to membrane
YMR140W	YMR140W	SIP5	hom	Verified	0.338536891685068	0.367479315470554	no	1823	0.349827506346887	1149	NA	FT	RESPONSE TO NUTRIENT LEVELS			Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress	cellular response to glucose starvation	molecular_function	cytoplasm
YJR087W_d	YJR087W	YJR087W	hom	Dubious	0.338097643042616	0.367644803325719	no	1824	0.364944601607977	1224	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2	Unknown	Unknown	Unknown
YDR347W	YDR347W	MRP1	hom	Verified	0.337906164207975	0.367716951075774	no	1825	0.374741084398198	1235	NA	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YLR376C	YLR376C	PSY3	hom	Verified	0.337402853193438	0.367906617045709	no	1826	0.357682746683578	1203	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C	recombinational repair|error-free translesion synthesis	molecular_function	nucleus|Shu complex|cytoplasm
YHR204W	YHR204W	MNL1	hom	Verified	0.337382264845076	0.367914376173266	no	1827	0.367199887646403	1233	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation	ER-associated protein catabolic process	carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum lumen
YHR114W	YHR114W	BZZ1	hom	Verified	0.337012063313674	0.368053903159857	no	1828	0.346177630170562	1156	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins	response to salt stress|actin filament organization|endocytosis	molecular_function	mating projection tip|cytoplasm|actin cortical patch
YLR224W_p	YLR224W	YLR224W	hom	Uncharacterized	0.336980257967452	0.368065891237864	no	1829	0.356305452434919	1191	NA	FT	PROTEOLYSIS			F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YDR333C	YDR333C	RQC1	hom	Verified	0.336840575735727	0.368118541816089	no	1830	0.355508128458609	1156	NA					Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC	biological_process	molecular_function	cytoplasm
YGL203C	YGL203C	KEX1	hom	Verified	0.33677570746528	0.368142993527493	no	1831	0.370374504790946	1236	NA	FT	PROTEOLYSIS	GOLGI APPARATUS		Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins	protein processing	serine-type carboxypeptidase activity	trans-Golgi network
YCR092C	YCR092C	MSH3	hom	Verified	0.336758231131798	0.368149581219523	no	1832	0.36775884930948	1232	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability	mismatch repair|mitotic recombination|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination	DNA insertion or deletion binding|mismatched DNA binding|double-strand/single-strand DNA junction binding|loop DNA binding|Y-form DNA binding	MutSbeta complex|nucleus|cytoplasm
YNL303W_d	YNL303W	YNL303W	hom	Dubious	0.336297935967455	0.368323103121706	no	1833	0.360729295331278	1218	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR010W	YHR010W	RPL27A	hom	Verified	0.335959158463846	0.368450832503715	no	1834	0.330088483464979	1095	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YNL241C	YNL241C	ZWF1	hom	Verified	0.335910352554994	0.368469235008323	no	1835	0.350102801529205	1168	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress	NADPH regeneration|response to hydrogen peroxide|pentose-phosphate shunt, oxidative branch|carbon catabolite repression of transcription	glucose-6-phosphate dehydrogenase activity	cytoplasm
YJL130C	YJL130C	URA2	hom	Verified	0.334374336693468	0.369048551197676	no	1836	0.347836199102404	1119	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM	MITOCHONDRION		Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP	glutamine metabolic process|'de novo' pyrimidine nucleobase biosynthetic process|negative regulation of pyrimidine nucleobase metabolic process	aspartate carbamoyltransferase activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	mitochondrion|integral to membrane|cytoplasm
YLR361C	YLR361C	DCR2	hom	Verified	0.334086669669379	0.369157079402773	no	1837	0.346236880902457	1175	NA	FT	CELL CYCLE|SIGNALING			Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START	endoplasmic reticulum unfolded protein response|traversing start control point of mitotic cell cycle|protein dephosphorylation	hydrolase activity, acting on ester bonds|phosphoprotein phosphatase activity|phosphoric ester hydrolase activity	cellular_component
YGR151C_d	YGR151C	YGR151C	hom	Dubious	0.333693957509595	0.369305254848532	no	1838	0.366815953254456	1235	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress	Unknown	Unknown	Unknown
YBR141C_p	YBR141C	YBR141C	hom	Uncharacterized	0.33361071469052	0.369336665950417	no	1839	0.35207566952411	1158	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleolus
YHL009C	YHL009C	YAP3	hom	Verified	0.332439782838188	0.369778601331003	no	1840	0.385409302352374	1269	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YAL046C	YAL046C	AIM1	hom	Verified	0.331782547796254	0.370026731688343	no	1841	0.375687491697229	1250	NA					Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YKL006W	YKL006W	RPL14A	hom	Verified	0.331462728453114	0.370147494810608	no	1842	0.386619569870315	1266	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YOR239W	YOR239W	ABP140	hom	Verified	0.330944561276641	0.370343180834202	no	1843	0.368621426494768	1213	NA	FT	RNA PROCESSING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift	actin filament bundle assembly|tRNA methylation	tRNA (cytosine-3-)-methyltransferase activity|actin filament binding|protein binding, bridging	actin filament|actin filament bundle|mating projection tip|actin cortical patch
YBL009W	YBL009W	ALK2	hom	Verified	0.330516563898308	0.370504839510754	no	1844	0.365464387377413	1183	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION			Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins	meiosis|mitosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YDR169C	YDR169C	STB3	hom	Verified	0.330310487657276	0.370582684623511	no	1845	0.360337750793092	1194	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter by glucose	sequence-specific DNA binding	nucleus|cytoplasm
YLL025W	YLL025W	PAU17	hom	Verified	0.329886576804126	0.370742833221356	no	1846	0.349014606084909	1154	NA					Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene	biological_process	molecular_function	cellular_component
YDR504C	YDR504C	SPG3	hom	Verified	0.329795036314941	0.370777419096532	no	1847	0.357999770000424	1184	NA					Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	biological_process	molecular_function	cellular_component
YLR282C_d	YLR282C	YLR282C	hom	Dubious	0.328620754533114	0.371221179367579	no	1848	0.360871493006861	1185	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition	Unknown	Unknown	Unknown
YGR087C	YGR087C	PDC6	hom	Verified	0.328511272100957	0.37126256143998	no	1849	0.378854894811385	1244	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation	L-phenylalanine catabolic process|ethanol metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	pyruvate decarboxylase activity	cytoplasm
YPL144W	YPL144W	POC4	hom	Verified	0.327146796964928	0.371778429263944	no	1850	0.360712922757319	1208	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions	proteasome assembly|chaperone-mediated protein complex assembly	molecular_function	intracellular|cytoplasm
YOL009C	YOL009C	MDM12	hom	Verified	0.327072986924877	0.3718063412385	no	1851	0.373384206084265	1214	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins	mitochondrion inheritance|mitochondrion organization|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrion|ERMES complex
YDL176W	YDL176W	YDL176W	hom	Verified	0.326888963627503	0.371875934347387	no	1852	0.35458980591435	1177	NA					Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene	biological_process	molecular_function	cellular_component
YIL132C	YIL132C	CSM2	hom	Verified	0.326722134216734	0.371939028767117	no	1853	0.344811286595412	1170	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis	meiotic chromosome segregation|recombinational repair|maintenance of rDNA|error-free translesion synthesis	molecular_function	nucleus|Shu complex|cytoplasm
YHL044W_p	YHL044W	YHL044W	hom	Uncharacterized	0.32643239827399	0.372048614267959	no	1854	0.362896623288723	1211	NA	FT		PLASMA MEMBRANE		Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern	biological_process	molecular_function	plasma membrane
YJR037W_d	YJR037W	YJR037W	hom	Dubious	0.326153182279275	0.372154230664375	no	1855	0.357100457885059	1175	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces	Unknown	Unknown	Unknown
YMR194C-A_d	YMR194C-A	YMR194C-A	hom	Dubious	0.325413504782635	0.372434067954848	no	1856	0.367970724894035	1227	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR415C_p	YLR415C	YLR415C	hom	Uncharacterized	0.325394544414169	0.37244124199164	no	1857	0.373442530812261	1252	NA	FT		MITOCHONDRION		Putative protein of unknown function; YLR415C is not an essential gene	biological_process	molecular_function	cellular_component
YBL096C_d	YBL096C	YBL096C	hom	Dubious	0.325281442397351	0.372484037334136	no	1858	0.364094405943851	1213	NA					Non-essential protein of unknown function	Unknown	Unknown	Unknown
YOR178C	YOR178C	GAC1	hom	Verified	0.325226956800638	0.3725046540605	no	1859	0.375703015404738	1245	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock	meiosis|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|response to heat|mitotic cell cycle spindle assembly checkpoint	protein phosphatase type 1 regulator activity|structural molecule activity|heat shock protein binding	protein phosphatase type 1 complex
YDR007W	YDR007W	TRP1	hom	Verified	0.3244504477579	0.372798515875872	no	1860	0.454400771466418	1496	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)	tryptophan biosynthetic process	phosphoribosylanthranilate isomerase activity	cytoplasm
YJR111C_p	YJR111C	YJR111C	hom	Uncharacterized	0.323044597197375	0.373330733750179	no	1861	0.365212758146486	1219	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria	biological_process	molecular_function	mitochondrion
YOR089C	YOR089C	VPS21	hom	Verified	0.322985315072704	0.373353181715025	no	1862	0.401841956401182	1320	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	MITOCHONDRION		Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication	endocytosis|vacuole inheritance|protein targeting to vacuole	GTP binding|GTPase activity	mitochondrial outer membrane|late endosome|mitochondrion
YOR234C	YOR234C	RPL33B	hom	Verified	0.322894120813422	0.37338771447315	no	1863	0.360404280373431	1205	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR196C	YGR196C	FYV8	hom	Verified	0.322491621933745	0.373540141875049	no	1864	0.374710269420855	1216	NA					Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	cytoplasm
YOL093W	YOL093W	TRM10	hom	Verified	0.322381317655725	0.373581917855275	no	1865	0.392802047101842	1319	NA	FT	RNA PROCESSING	NUCLEUS		tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress	tRNA methylation	tRNA (guanine) methyltransferase activity	nucleus|cytoplasm
YOR129C	YOR129C	AFI1	hom	Verified	0.320462193117859	0.374308992936742	no	1866	0.367537543179983	1225	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p	asymmetric protein localization|actin cortical patch localization|cellular bud site selection	molecular_function	nucleus|plasma membrane|cellular bud neck|cytoplasm
YHL028W	YHL028W	WSC4	hom	Verified	0.320174513714295	0.374418021098973	no	1867	0.364916313912733	1212	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3	response to heat|SRP-dependent cotranslational protein targeting to membrane, translocation|protein targeting to ER|response to stress	transmembrane signaling receptor activity	endoplasmic reticulum membrane
YJL147C_p	YJL147C	YJL147C	hom	Uncharacterized	0.31988177622881	0.374528976542409	no	1868	0.365910296490934	1240	NA	FT		MITOCHONDRION		Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene	biological_process	molecular_function	mitochondrion
YDR059C	YDR059C	UBC5	hom	Verified	0.318990012129793	0.374867043314459	no	1869	0.376793328558955	1242	NA					Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication	protein polyubiquitination|response to stress	ubiquitin-protein ligase activity	proteasome complex
YOR091W	YOR091W	TMA46	hom	Verified	0.318439560510308	0.375075766930509	no	1870	0.390957637624182	1312	NA	FT	TRANSLATION			Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p	cytoplasmic translation	molecular_function	polysomal ribosome|ribosome|cytoplasm
YJL004C	YJL004C	SYS1	hom	Verified	0.318321415143614	0.375120570785569	no	1871	0.389867907302041	1298	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation	vesicle organization|Golgi to plasma membrane protein transport|Golgi to endosome transport	molecular_function	trans-Golgi network|integral to membrane|integral to Golgi membrane
YGL179C	YGL179C	TOS3	hom	Verified	0.318034327679871	0.375229448983347	no	1872	0.362132441932698	1242	NA	FT	CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION			Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome	protein phosphorylation|glucose metabolic process	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YER067C-A_d	YER067C-A	YER067C-A	hom	Dubious	0.316909367123294	0.375656187087413	no	1873	0.363735643035911	1185	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W	Unknown	Unknown	Unknown
YNL254C	YNL254C	RTC4	hom	Verified	0.316525428254994	0.375801863797068	no	1874	0.352997726995418	1164	NA	FT		NUCLEUS		Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YKR001C	YKR001C	VPS1	hom	Verified	0.315801148082248	0.37607672331718	no	1875	0.42372217586523	1367	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION	MITOCHONDRION|CYTOSKELETON		Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis	vacuolar transport|peroxisome fission|endocytosis|actin cytoskeleton organization|protein retention in Golgi apparatus|peroxisome organization|lipid tube assembly|protein targeting to vacuole	GTPase activity	mitochondrial outer membrane|fungal-type vacuole membrane|peroxisome|actin cortical patch
YMR116C	YMR116C	ASC1	hom	Verified	0.31536842629358	0.376240968377362	no	1876	0.375157573983445	1244	NA	FT	SIGNALING|TRANSLATION		RIBOSOME	G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation	negative regulation of translation|glucose mediated signaling pathway|G-protein coupled receptor signaling pathway|invasive growth in response to glucose limitation	G-protein alpha-subunit binding|GDP-dissociation inhibitor activity|signal transducer activity	cytosolic small ribosomal subunit|cytoplasm
YLR189C	YLR189C	ATG26	hom	Verified	0.31504099273935	0.376365264848094	no	1877	0.349614296341905	1171	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM			UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy	sterol metabolic process|ascospore-type prospore membrane assembly	sterol 3-beta-glucosyltransferase activity	cytoplasm
YDR173C	YDR173C	ARG82	hom	Verified	0.314893311279812	0.376421330141565	no	1878	0.358169107914616	1183	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes	protein stabilization|negative regulation of transcription from RNA polymerase II promoter|phosphatidylinositol phosphorylation|regulation of arginine metabolic process|inositol phosphate biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	inositol-1,4,5-trisphosphate 3-kinase activity|inositol-1,4,5-trisphosphate 6-kinase activity|phosphatidylinositol 3-kinase activity|protein binding, bridging|inositol tetrakisphosphate 6-kinase activity|inositol tetrakisphosphate 3-kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity	nucleus
YDR046C	YDR046C	BAP3	hom	Verified	0.31418362449282	0.376690789601375	no	1879	0.355497684486227	1188	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YHR033W_p	YHR033W	YHR033W	hom	Uncharacterized	0.314049054907155	0.376741890820752	no	1880	0.362267516097445	1213	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YOR093C_p	YOR093C	YOR093C	hom	Uncharacterized	0.313769626943229	0.376848007204762	no	1881	0.343128054677208	1130	NA	FT		NUCLEUS		Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents	biological_process	molecular_function	integral to membrane
YBR095C	YBR095C	RXT2	hom	Verified	0.313435020729399	0.376975090483942	no	1882	0.399443874254675	1291	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth	conjugation with cellular fusion|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|invasive growth in response to glucose limitation	histone deacetylase activity	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YKL090W	YKL090W	CUE2	hom	Verified	0.313396372300399	0.376989769997624	no	1883	0.369008880921766	1197	NA					Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination	biological_process	ubiquitin binding	cellular_component
YFL063W_d	YFL063W	YFL063W	hom	Dubious	0.312943867847584	0.377161654250282	no	1884	0.343953838212295	1160	NA					Dubious open reading frame, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR356W	YOR356W	CIR2	hom	Verified	0.312168171553556	0.377456359847161	no	1885	0.374168156134385	1245	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YIL030C	YIL030C	SSM4	hom	Verified	0.312150890384321	0.377462926190483	no	1886	0.390262349662662	1321	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation	ER-associated protein catabolic process	ubiquitin-protein ligase activity	nuclear envelope|integral to endoplasmic reticulum membrane|Doa10p ubiquitin ligase complex|integral to membrane|nuclear inner membrane
YKL190W	YKL190W	CNB1	hom	Verified	0.310792853013332	0.377979051642943	no	1887	0.377255781366404	1258	NA	FF|FT	SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding	calcineurin complex
YGL237C	YGL237C	HAP2	hom	Verified	0.310756459660942	0.37799288602787	no	1888	0.372121234214414	1234	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex|nucleus
YBR097W	YBR097W	VPS15	hom	Verified	0.310705084966408	0.37801241561076	no	1889	0.378712152194266	1221	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery	protein retention in Golgi apparatus|vacuole inheritance|peroxisome degradation|protein phosphorylation|macroautophagy|inositol lipid-mediated signaling|late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding|protein serine/threonine kinase activity	mitochondrion|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|Golgi membrane
YBL043W	YBL043W	ECM13	hom	Verified	0.310081619971115	0.378249444506535	no	1890	0.350545162342306	1164	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cellular_component
YNR070W_p	YNR070W	PDR18	hom	Uncharacterized	0.310032913514139	0.378267963656324	no	1891	0.356754630088549	1202	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	transport	ATPase activity, coupled to transmembrane movement of substances	mitochondrion|integral to membrane|membrane
YCR048W	YCR048W	ARE1	hom	Verified	0.309865068111831	0.378331783910827	no	1892	0.363776983390961	1208	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication	sterol metabolic process	ergosterol O-acyltransferase activity|lanosterol O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YCL051W	YCL051W	LRE1	hom	Verified	0.307330233459543	0.379296012755818	no	1893	0.390299514525164	1286	NA	FT	CELL WALL ORG/BIOGENESIS			Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; <br>LRE1 has a paralog, HLR1, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cellular_component
YDR124W_p	YDR124W	YDR124W	hom	Uncharacterized	0.306454094023123	0.37962946354307	no	1894	0.369332979709874	1195	NA					Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor	biological_process	molecular_function	cellular_component
YIR003W	YIR003W	AIM21	hom	Verified	0.306004377957454	0.379800656222955	no	1895	0.355853407291022	1178	NA	FT		SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton	mitochondrion migration along actin filament	molecular_function	ribosome|mating projection tip|actin cytoskeleton
YNL089C_d	YNL089C	YNL089C	hom	Dubious	0.305753547950571	0.379896149508893	no	1896	0.388216447282236	1253	NA					Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins	Unknown	Unknown	Unknown
YBR056W	YBR056W	YBR056W	hom	Verified	0.305137465476532	0.380130728836488	no	1897	0.36295535356791	1226	NA	FT	CARBOHYDRATE METABOLISM			Putative glycoside hydrolase of the mitochondrial intermembrane space	biological_process	molecular_function	cytoplasm
YBR258C	YBR258C	SHG1	hom	Verified	0.303809454356672	0.380636531732395	no	1898	0.378778287323209	1250	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres	histone H3-K4 methylation	histone methyltransferase activity (H3-K4 specific)	nucleus|Set1C/COMPASS complex
YPL096W	YPL096W	PNG1	hom	Verified	0.302260943475808	0.381226574626581	no	1899	0.390105743007617	1298	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS|MITOCHONDRION		Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p	misfolded or incompletely synthesized protein catabolic process|protein deglycosylation	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity	cytosol|mitochondrion|nucleus
YPL236C	YPL236C	ENV7	hom	Verified	0.301888696564906	0.381368456415171	no	1900	0.360836802225528	1203	NA	FT	PROTEIN PHOSPHORYLATION|VACUOLAR PROTEIN PROCESSING			Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)	vacuolar protein processing	protein serine/threonine kinase activity	fungal-type vacuole membrane
YKR024C	YKR024C	DBP7	hom	Verified	0.301606963553118	0.381475849462428	no	1901	0.386067007715813	1276	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus
YNR039C	YNR039C	ZRG17	hom	Verified	0.300791099738369	0.381786897841746	no	1902	0.361909784805434	1193	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency	zinc ion transport	zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YOR170W_d	YOR170W	YOR170W	hom	Dubious	0.299363063995139	0.382331520636219	no	1903	0.383582846381862	1277	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4	Unknown	Unknown	Unknown
YMR262W_p	YMR262W	YMR262W	hom	Uncharacterized	0.298503345559419	0.382659511529499	no	1904	0.37558252908205	1264	NA					Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene	biological_process	molecular_function	cellular_component
YHL035C	YHL035C	VMR1	hom	Verified	0.296979717076209	0.383240997181777	no	1905	0.390868235260874	1304	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions	transport|response to drug|response to metal ion|drug transport	ATPase activity, coupled to transmembrane movement of substances	fungal-type vacuole membrane|mitochondrion|integral to membrane|ribosome
YKR106W	YKR106W	GEX2	hom	Verified	0.296571402586823	0.383396873253392	no	1906	0.370464496469892	1234	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway	glutathione transmembrane transport	solute:hydrogen antiporter activity	integral to membrane|plasma membrane|vacuolar membrane
YKL133C_p	YKL133C	YKL133C	hom	Uncharacterized	0.29595091148844	0.383633784924102	no	1907	0.395836204865522	1300	NA					Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)	biological_process	molecular_function	cellular_component
YLR081W	YLR081W	GAL2	hom	Verified	0.295615731142831	0.383761779297869	no	1908	0.364853850936039	1228	NA	FT	CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Galactose permease, required for utilization of galactose; also able to transport glucose	galactose transport|galactose metabolic process	galactose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YJL191W	YJL191W	RPS14B	hom	Verified	0.295200783651615	0.383920251694755	no	1909	0.391866606675621	1297	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome|SSU rRNA binding	small-subunit processome|cytosolic small ribosomal subunit
YFL044C	YFL044C	OTU1	hom	Verified	0.294248111397718	0.384284159705119	no	1910	0.369103823244945	1229	NA	FT	PROTEOLYSIS	NUCLEUS		Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress	protein deubiquitination|regulation of transcription, DNA-dependent	ubiquitin-specific protease activity	nucleus|cytoplasm
YGR289C	YGR289C	MAL11	hom	Verified	0.293793224110857	0.384457956548354	no	1911	0.396112278729359	1322	NA	FT	CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization	trehalose transport|maltose transport|disaccharide catabolic process	trehalose transmembrane transporter activity|alpha-glucoside:hydrogen symporter activity|maltose:hydrogen symporter activity	integral to membrane|plasma membrane
YEL038W	YEL038W	UTR4	hom	Verified	0.293269670764626	0.384658017090042	no	1912	0.356049499958354	1210	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus	L-methionine salvage from methylthioadenosine	acireductone synthase activity	nucleus|cytoplasm
YGL015C_p	YGL015C	YGL015C	hom	Uncharacterized	0.291671397022502	0.385268940303352	no	1913	0.375656963409416	1245	NA					Putative protein of unknown function; null mutants accumulate cargo in the Golgi	biological_process	molecular_function	cellular_component
YOR263C_d	YOR263C	YOR263C	hom	Dubious	0.291522879615648	0.385325723996364	no	1914	0.384081700003744	1288	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W	Unknown	Unknown	Unknown
YBR232C_d	YBR232C	YBR232C	hom	Dubious	0.291433237105993	0.385359998830384	no	1915	0.382154581214432	1281	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR173W	YMR173W	DDR48	hom	Verified	0.290888626916258	0.3855682498968	no	1916	0.375789761196267	1266	NA	FT	RESPONSE TO DNA DAMAGE			DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress	DNA repair	ATPase activity|GTPase activity	cytoplasm
YPR001W	YPR001W	CIT3	hom	Verified	0.288527637308985	0.386471439036363	no	1917	0.398791592403854	1299	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate	propionate catabolic process, 2-methylcitrate cycle|propionate metabolic process|tricarboxylic acid cycle	2-methylcitrate synthase activity|citrate (Si)-synthase activity	mitochondrion
YBR262C	YBR262C	AIM5	hom	Verified	0.288096405679113	0.386636471948064	no	1918	0.349340747752009	1144	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YPR013C_p	YPR013C	CMR3	hom	Uncharacterized	0.28732799966039	0.386930592743595	no	1919	0.381480950937825	1257	NA					Putative zinc finger protein; YPR013C is not an essential gene	biological_process	sequence-specific DNA binding	cellular_component
YMR071C	YMR071C	TVP18	hom	Verified	0.287123749485916	0.387008783989916	no	1920	0.400961307190866	1315	NA	FF|FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments	vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|clathrin-coated vesicle
YJR083C	YJR083C	ACF4	hom	Verified	0.285821502736098	0.387507419027216	no	1921	0.377359282976856	1262	NA					Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate	biological_process	molecular_function	cellular_component
YAR014C	YAR014C	BUD14	hom	Verified	0.28563264164457	0.387579750060389	no	1922	0.385485586771507	1309	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress	regulation of cell shape during vegetative growth phase|regulation of protein localization|regulation of transcription, DNA-dependent|cytoskeleton organization|negative regulation of actin filament polymerization	protein phosphatase type 1 regulator activity	incipient cellular bud site|cellular bud neck|cellular bud tip
YGL170C	YGL170C	SPO74	hom	Verified	0.285448489732644	0.387650281304001	no	1923	0.388822888555384	1282	NA	FT		NUCLEUS|CYTOSKELETON		Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation	ascospore formation	structural molecule activity	spindle pole body
YDR258C	YDR258C	HSP78	hom	Verified	0.28509033937384	0.387787465571087	no	1924	0.383241066538646	1296	NA	FT	PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates	positive regulation of mitochondrial translation in response to stress|protein refolding|protein stabilization|protein import into mitochondrial matrix|mitochondrial genome maintenance|protein unfolding|cellular response to heat	misfolded protein binding|ATPase activity	mitochondrion|mitochondrial matrix
YKL092C	YKL092C	BUD2	hom	Verified	0.28307823485881	0.388558432783292	no	1925	0.386609395497257	1280	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		GTPase activating factor for Rsr1p/Bud1p; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; mutant deficient in mitotic spindle position checkpoint	bipolar cellular bud site selection|small GTPase mediated signal transduction|filamentous growth|cellular bud site selection|axial cellular bud site selection	GTPase activator activity|Ras GTPase activator activity	intracellular
YCR031C	YCR031C	RPS14A	hom	Verified	0.282955135630645	0.388605614337113	no	1926	0.38922859284326	1270	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome|mRNA binding	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YJR137C	YJR137C	MET5	hom	Verified	0.282870656629576	0.388637994455634	no	1927	0.35290674657076	1180	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS			Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine	fungal-type cell wall organization|sulfate assimilation	sulfite reductase (NADPH) activity	sulfite reductase complex (NADPH)|cytoplasm
YOL082W	YOL082W	ATG19	hom	Verified	0.282546545378012	0.388762230856859	no	1928	0.368931170190671	1217	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles	vesicle organization|ER-associated protein catabolic process|protein processing|protein complex localization|CVT pathway	protein binding, bridging	pre-autophagosomal structure|cytoplasm|CVT complex|extrinsic to membrane
YER087C-A_d	YER087C-A	YER087C-A	hom	Dubious	0.282268852758341	0.388868683394188	no	1929	0.380082712843187	1275	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase	Unknown	Unknown	Unknown
YBR233W	YBR233W	PBP2	hom	Verified	0.281170134238138	0.389289955215649	no	1930	0.401065759290833	1307	NA	FT		NUCLEUS		RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress	telomere maintenance via telomere shortening	mRNA binding	cytoplasm
YKL116C	YKL116C	PRR1	hom	Verified	0.280840960542665	0.389416192704498	no	1931	0.353112805107191	1192	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION			Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor	negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation	protein kinase activity|receptor signaling protein serine/threonine kinase activity	cytoplasm
YDR130C	YDR130C	FIN1	hom	Verified	0.280335492034361	0.389610061635827	no	1932	0.400138504343643	1339	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress	intermediate filament cytoskeleton organization|mitotic cell cycle spindle checkpoint|mitotic spindle stabilization|mitotic sister chromatid segregation	microtubule binding|structural constituent of cytoskeleton	spindle microtubule|condensed nuclear chromosome kinetochore|intermediate filament|nucleus|spindle pole body|astral microtubule|spindle
YNL217W_p	YNL217W	YNL217W	hom	Uncharacterized	0.279596406390964	0.389893582236098	no	1933	0.387328485814759	1285	NA					Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate	biological_process	phosphatase activity	fungal-type vacuole
YHR140W_p	YHR140W	YHR140W	hom	Uncharacterized	0.279543051785163	0.389914051862649	no	1934	0.375711396599628	1244	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative integral membrane protein of unknown function	biological_process	molecular_function	integral to membrane
YPL156C	YPL156C	PRM4	hom	Verified	0.279354610533245	0.389986350258261	no	1935	0.378262289655916	1276	NA					Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift	biological_process	molecular_function	integral to membrane
YLR177W_p	YLR177W	YLR177W	hom	Uncharacterized	0.277926554081522	0.390534369706334	no	1936	0.39145938836458	1282	NA					Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YNL270C	YNL270C	ALP1	hom	Verified	0.277828534689271	0.39057199282956	no	1937	0.384532062346206	1290	NA	FT		PLASMA MEMBRANE		Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication	basic amino acid transport	basic amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YEL065W	YEL065W	SIT1	hom	Verified	0.277478357651536	0.390706410862493	no	1938	0.379859927814577	1278	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p	cellular iron ion homeostasis|siderophore transport|transmembrane transport	siderophore uptake transmembrane transporter activity	endosome|integral to membrane|cytoplasmic membrane-bounded vesicle
YLR200W	YLR200W	YKE2	hom	Verified	0.276738072420351	0.390990617770942	no	1939	0.417051880561722	1393	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin	protein folding|tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YLL017W	YLL017W	YLL017W	hom	pseudogene	0.276623484379693	0.391034615093508	no	1940	0.358901638152792	1183	NA	FT	SIGNALING			Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication	Ras protein signal transduction	Ras guanyl-nucleotide exchange factor activity	membrane
YOR337W	YOR337W	TEA1	hom	Verified	0.275793384345713	0.391353382628616	no	1941	0.379802151070294	1268	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein	transcription, DNA-dependent	sequence-specific DNA binding|DNA binding	nucleus
YLR288C	YLR288C	MEC3	hom	Verified	0.275406534389479	0.391501962207596	no	1942	0.384919486770494	1256	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1	telomere maintenance via recombination|DNA damage checkpoint|DNA metabolic process|chromatin silencing at telomere	DNA binding	nucleus|checkpoint clamp complex
YPL205C_d	YPL205C	YPL205C	hom	Dubious	0.273818392854027	0.392112094089105	no	1943	0.359901094032883	1238	NA					Hypothetical protein; deletion of locus affects telomere length	Unknown	Unknown	Unknown
YDL222C	YDL222C	FMP45	hom	Verified	0.272994737957253	0.392428630251815	no	1944	0.378890847708769	1265	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C	fungal-type cell wall organization|ascospore formation	molecular_function	cell cortex|mitochondrion|integral to membrane|plasma membrane
YNL180C	YNL180C	RHO5	hom	Verified	0.272976219724355	0.392435747753236	no	1945	0.386043908534897	1230	NA	FT	SIGNALING	NUCLEUS|PLASMA MEMBRANE		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity	Rho protein signal transduction	GTPase activity	endomembrane system|fungal-type vacuole membrane|plasma membrane|nucleus|cytoplasm
YLR265C	YLR265C	NEJ1	hom	Verified	0.272969317521609	0.392438400631	no	1946	0.381674743684384	1269	NA	FT	RESPONSE TO DNA DAMAGE	ENDOMEMBRANE SYSTEM|NUCLEUS		Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p	double-strand break repair via nonhomologous end joining|double-strand break repair via single-strand annealing	DNA end binding	DNA ligase IV complex|nucleus
YOR107W	YOR107W	RGS2	hom	Verified	0.272357629909315	0.392673524030877	no	1947	0.403947896115014	1365	NA	FT	SIGNALING	NUCLEUS|PLASMA MEMBRANE		Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	GTPase activator activity	nucleus|cytoplasm
YGR157W	YGR157W	CHO2	hom	Verified	0.272186533498731	0.392739297899406	no	1948	0.393806203928337	1314	NA	FT	LIPID METABOLISM			Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis	phosphatidylcholine biosynthetic process	phosphatidylethanolamine N-methyltransferase activity	integral to membrane|endoplasmic reticulum
YOR376W_d	YOR376W	YOR376W	hom	Dubious	0.271218673017696	0.393111426027029	no	1949	0.384920599560315	1259	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.	Unknown	Unknown	Unknown
YPL077C_p	YPL077C	YPL077C	hom	Uncharacterized	0.271164308130581	0.39313233142794	no	1950	0.395413967932898	1300	NA					Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDR108W	YDR108W	TRS85	hom	Verified	0.270033577899219	0.393567210696437	no	1951	0.416798379860261	1387	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	GOLGI APPARATUS		Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role	meiosis|vesicle organization|piecemeal microautophagy of nucleus|ER to Golgi vesicle-mediated transport|peroxisome degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway	molecular_function	TRAPP complex|pre-autophagosomal structure
YJL132W_p	YJL132W	YJL132W	hom	Uncharacterized	0.269002407908657	0.393963914851364	no	1952	0.399858048949687	1339	NA					Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene	biological_process	molecular_function	membrane
YNL332W	YNL332W	THI12	hom	Verified	0.268918751446598	0.393996103383536	no	1953	0.377702115122425	1236	NA					Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13	thiamine biosynthetic process	molecular_function	cellular_component
YKL002W	YKL002W	DID4	hom	Verified	0.268513721398854	0.394151957202329	no	1954	0.392916316223343	1306	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis	protein retention in Golgi apparatus|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	molecular_function	ESCRT III complex|cytoplasm
YBL011W	YBL011W	SCT1	hom	Verified	0.2681023632187	0.394310263409412	no	1955	0.386947300731742	1271	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed	phospholipid biosynthetic process	glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YLR018C	YLR018C	POM34	hom	Verified	0.26797786841957	0.394358177165915	no	1956	0.338744445812145	1135	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication	nuclear pore organization|protein import into nucleus|spindle pole body duplication associated with nuclear envelope	structural constituent of nuclear pore	nuclear pore transmembrane ring|integral to membrane|integral to nuclear outer membrane|nuclear pore
YHR158C	YHR158C	KEL1	hom	Verified	0.267903789147799	0.394386688482531	no	1957	0.375458128453925	1261	NA	FT	CELL CYCLE|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH		Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate	negative regulation of exit from mitosis|regulation of cell shape|cell morphogenesis|cytogamy|plasma membrane fusion	molecular_function	mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YMR255W	YMR255W	GFD1	hom	Verified	0.267441350816425	0.394564682575942	no	1958	0.390604890943495	1318	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress	mRNA export from nucleus	molecular_function	integral to membrane|nuclear pore|cytoplasm
YLR264W	YLR264W	RPS28B	hom	Verified	0.265835479670163	0.395182958602907	no	1959	0.373313451651748	1250	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR253C	YDR253C	MET32	hom	Verified	0.265414886647201	0.395344934698425	no	1960	0.415306529739273	1384	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication	regulation of mitotic cell cycle|regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YCR095W-A_p	YCR095W-A	YCR095W-A	hom	Uncharacterized	0.265265257777905	0.39540256317396	no	1961	0.395827037927553	1297	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBL072C	YBL072C	RPS8A	hom	Verified	0.264332527928559	0.395761848845548	no	1962	0.371544514924264	1263	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YKL041W	YKL041W	VPS24	hom	Verified	0.263734177904905	0.395992378741333	no	1963	0.408805432115773	1339	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway	intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	molecular_function	ESCRT III complex|cytoplasm
YDR273W	YDR273W	DON1	hom	Verified	0.263270343098042	0.396171108190801	no	1964	0.383011260821203	1306	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION			Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II	meiosis|ascospore wall assembly	molecular_function	prospore membrane
YDR179C	YDR179C	CSN9	hom	Verified	0.262367142064555	0.396519201212056	no	1965	0.396933306581287	1313	NA	FT	SIGNALING	NUCLEUS		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	molecular_function	signalosome
YDR102C_d	YDR102C	YDR102C	hom	Dubious	0.261949079092156	0.396680350323659	no	1966	0.389653794812658	1287	NA					Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index	Unknown	Unknown	Unknown
YOR020W-A_p	YOR020W-A	YOR020W-A	hom	Uncharacterized	0.261112898804511	0.397002722419485	no	1967	0.400220933508539	1310	NA	FT		MITOCHONDRION		Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YIL094C	YIL094C	LYS12	hom	Verified	0.260320552283165	0.397308260267595	no	1968	0.400375849102863	1335	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate	lysine biosynthetic process	homoisocitrate dehydrogenase activity	mitochondrion
YLR053C_p	YLR053C	YLR053C	hom	Uncharacterized	0.259204418517362	0.397738761050116	no	1969	0.382943092617666	1253	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPR154W	YPR154W	PIN3	hom	Verified	0.258933093121891	0.397843432037351	no	1970	0.397830999535322	1321	NA	FT	CYTOSKELETON ORGANIZATION	NUCLEUS		Protein that induces appearance of [PIN+] prion when overproduced	actin cytoskeleton organization	molecular_function	nucleus|cytoplasm
YGL043W	YGL043W	DST1	hom	Verified	0.258834135461748	0.397881609417093	no	1971	0.400527271580015	1302	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION	NUCLEUS		General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress	transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|mRNA cleavage|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|tRNA transcription from RNA polymerase III promoter|regulation of mRNA 3'-end processing|positive regulation of transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|transcription antitermination|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter	RNA polymerase II regulatory region DNA binding|RNA polymerase II core binding|core RNA polymerase II recruiting transcription factor activity	nucleus
YIL029C_p	YIL029C	YIL029C	hom	Uncharacterized	0.258809913357663	0.397890954334987	no	1972	0.405367853087184	1363	NA					Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W	biological_process	molecular_function	integral to membrane
YML087C	YML087C	AIM33	hom	Verified	0.258466721095529	0.398023364629524	no	1973	0.391701977373851	1256	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YNL233W	YNL233W	BNI4	hom	Verified	0.258445138263513	0.398031692101431	no	1974	0.433087473079238	1422	NA	FT	PROTEIN LOCALIZATION|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|CYTOSKELETON		Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p	asymmetric protein localization|barrier septum assembly|chitin biosynthetic process	protein binding	incipient cellular bud site|cellular bud neck septin collar|cellular bud neck|septin ring
YEL007W	YEL007W	MIT1	hom	Verified	0.258366794907672	0.398061920317919	no	1975	0.381341270536054	1267	NA	FT		NUCLEUS		Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1	biological_process	molecular_function	nucleus|cytoplasm
YFR054C_d	YFR054C	YFR054C	hom	Dubious	0.256810013367297	0.398662719857127	no	1976	0.373437591848924	1256	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER101C	YER101C	AST2	hom	Verified	0.255986061732599	0.398980799975613	no	1977	0.407048816409424	1333	NA	FT	PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS			Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication	protein targeting to membrane	molecular_function	cytoplasm
YJL193W_p	YJL193W	YJL193W	hom	Uncharacterized	0.254766408049351	0.39945176090091	no	1978	0.401592714822797	1306	NA					Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect	biological_process	molecular_function	integral to membrane
YBL098W	YBL098W	BNA4	hom	Verified	0.254598591237688	0.399516573684115	no	1979	0.389752063359989	1279	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease	de novo NAD biosynthetic process from tryptophan	kynurenine 3-monooxygenase activity	mitochondrial outer membrane|mitochondrion
YJL100W	YJL100W	LSB6	hom	Verified	0.254212547897605	0.399665678572509	no	1980	0.418867544170045	1416	NA	FT	LIPID METABOLISM	PLASMA MEMBRANE		Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization	phosphatidylinositol phosphorylation	1-phosphatidylinositol 4-kinase activity	fungal-type vacuole membrane|plasma membrane|cytoplasm
YDR323C	YDR323C	PEP7	hom	Verified	0.25324222278768	0.400040520277665	no	1981	0.42290127822518	1364	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance	Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol-3-phosphate binding	external side of endosome membrane|cytoplasm
YOR292C_p	YOR292C	YOR292C	hom	Uncharacterized	0.253198324970657	0.400057480416322	no	1982	0.380407866481711	1263	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YLR309C	YLR309C	IMH1	hom	Verified	0.252527809356785	0.400316560851301	no	1983	0.384811999127224	1282	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi	Golgi to plasma membrane protein transport|vesicle-mediated transport	molecular_function	cytosol|Golgi apparatus
YPL194W	YPL194W	DDC1	hom	Verified	0.251631404983039	0.400662990925575	no	1984	0.394282661456736	1294	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress	meiosis|mitotic cell cycle G1/S transition checkpoint|intra-S DNA damage checkpoint|recombinational repair|G2/M transition checkpoint|cell cycle checkpoint	molecular_function	condensed nuclear chromosome|checkpoint clamp complex
YGL234W	YGL234W	ADE5,7	hom	Verified	0.251467744438883	0.400726248653545	no	1985	0.400251992867083	1322	NA	FT	NUCLEOTIDE METABOLISM			Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities	purine nucleobase metabolic process|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity	cytoplasm
YNL058C_p	YNL058C	YNL058C	hom	Uncharacterized	0.251334251364453	0.400777848042724	no	1986	0.381051406097059	1267	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene	biological_process	molecular_function	fungal-type vacuole
YEL064C	YEL064C	AVT2	hom	Verified	0.250000507636563	0.401293478030215	no	1987	0.386064552013389	1297	NA	FT		ENDOPLASMIC RETICULUM		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	transport	transporter activity	integral to membrane|endoplasmic reticulum
YGL222C	YGL222C	EDC1	hom	Verified	0.249938670355926	0.401317388716839	no	1988	0.396428155236098	1314	NA	FT	RNA PROCESSING|TRANSLATION	NUCLEUS		RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of translation in response to stress	mRNA binding	nucleus|cytoplasm
YIL111W	YIL111W	COX5B	hom	Verified	0.249891197744429	0.401335745252433	no	1989	0.38525669530451	1300	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity|nitrite reductase (NO-forming) activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YGL121C	YGL121C	GPG1	hom	Verified	0.249490881219847	0.401490546837194	no	1990	0.384351894156148	1286	NA	FT	SIGNALING			Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing	signal transduction|invasive growth in response to glucose limitation	signal transducer activity	cellular_component
YBL095W_p	YBL095W	YBL095W	hom	Uncharacterized	0.248617434683232	0.401828360473636	no	1991	0.364786431603081	1234	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPL061W	YPL061W	ALD6	hom	Verified	0.248220335547336	0.401981966561043	no	1992	0.38698213162283	1278	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress	response to salt stress|NADPH regeneration|acetate biosynthetic process	aldehyde dehydrogenase [NAD(P)+] activity	cytosol|mitochondrion
YFR032C-B_p	YFR032C-B	YFR032C-B	hom	Uncharacterized	0.246898300033692	0.402493465992641	no	1993	0.390228603739753	1310	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YER091C	YER091C	MET6	hom	Verified	0.246738123387839	0.402555450166604	no	1994	0.324169126299094	1092	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs	methionine biosynthetic process	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	plasma membrane|cytoplasm
YGL190C	YGL190C	CDC55	hom	Verified	0.24377034326767	0.403704345086847	no	1995	0.481920127917403	1758	NA	FT	CELL CYCLE|SIGNALING	NUCLEUS|SITE OF POLARIZED GROWTH		Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion	negative regulation of exit from mitosis|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|protein dephosphorylation	protein phosphatase type 2A regulator activity	nucleus|cellular bud neck|cytoplasm|cellular bud tip
YLR181C	YLR181C	VTA1	hom	Verified	0.243467901849968	0.403821473856276	no	1996	0.402527442109939	1329	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT			Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain	late endosome to vacuole transport via multivesicular body sorting pathway|positive regulation of protein oligomerization|late endosome to vacuole transport	ATPase activator activity	endosome|endosome membrane|multivesicular body
YCL076W_d	YCL076W	YCL076W	hom	Dubious	0.243388877497515	0.40385207963505	no	1997	0.384417078976496	1281	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAL030W	YAL030W	SNC1	hom	Verified	0.241934886079763	0.40441530888852	no	1998	0.396697237835089	1310	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication	endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion	SNAP receptor activity	SNARE complex|trans-Golgi network|endosome|transport vesicle membrane|plasma membrane|cellular bud neck
YIL163C_p	YIL163C	YIL163C	hom	Uncharacterized	0.241616569402608	0.404538640954235	no	1999	0.401807469732818	1313	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YJR128W_d	YJR128W	YJR128W	hom	Dubious	0.240422185762335	0.405001490381327	no	2000	0.398171640685161	1332	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2	Unknown	Unknown	Unknown
YOR226C	YOR226C	ISU2	hom	Verified	0.239760070695032	0.405258131564052	no	2001	0.400571180466943	1315	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved	cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification	molecular_function	mitochondrial matrix
YHR117W	YHR117W	TOM71	hom	Verified	0.239063618750015	0.405528125966723	no	2002	0.404505629981158	1328	NA	FT		MITOCHONDRION		Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication	biological_process	protein transporter activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane
YPL026C	YPL026C	SKS1	hom	Verified	0.238676894154226	0.405678067398364	no	2003	0.357005246892159	1217	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION	NUCLEUS		Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway	glucose transport|protein phosphorylation|response to glucose stimulus|positive regulation of transcription from RNA polymerase II promoter	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YFL030W	YFL030W	AGX1	hom	Verified	0.238649607673535	0.405688647475951	no	2004	0.405579210334927	1342	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases	glycine biosynthetic process, by transamination of glyoxylate	alanine-glyoxylate transaminase activity	mitochondrion
YIR007W_p	YIR007W	YIR007W	hom	Uncharacterized	0.238434873317885	0.405771911117162	no	2005	0.398574870567265	1296	NA	FT	CARBOHYDRATE METABOLISM			Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene	biological_process	molecular_function	cytoplasm
YPL170W	YPL170W	DAP1	hom	Verified	0.238166487659592	0.405875984143222	no	2006	0.433465871109272	1422	NA	FT	LIPID METABOLISM			Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis	regulation of ergosterol biosynthetic process	heme binding	endosome|membrane
YML003W_p	YML003W	YML003W	hom	Uncharacterized	0.237627943758806	0.406084837618371	no	2007	0.393456709861223	1297	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YFL046W_p	YFL046W	FMP32	hom	Uncharacterized	0.236395147389153	0.406563030662926	no	2008	0.414029957752967	1364	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YNL211C_p	YNL211C	YNL211C	hom	Uncharacterized	0.236149700362627	0.406658254498234	no	2009	0.406253855561091	1361	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene	biological_process	molecular_function	mitochondrion
YML041C	YML041C	VPS71	hom	Verified	0.235888045743456	0.406759772323003	no	2010	0.408038720859786	1355	NA	FF|FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|VACUOLAR TRANSPORT	NUCLEUS|CHROMOSOME		Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting	chromatin remodeling|protein targeting to vacuole|histone exchange	nucleosome binding	Swr1 complex|nucleus
YHR100C	YHR100C	GEP4	hom	Verified	0.235709260534314	0.406829141740445	no	2011	0.440186158229271	1461	NA	FF|FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT	cardiolipin biosynthetic process|phosphorylated carbohydrate dephosphorylation	phosphatidylglycerophosphatase activity	mitochondrion|mitochondrial matrix
YKL076C_d	YKL076C	PSY1	hom	Dubious	0.235483773351159	0.406916635889683	no	2012	0.412379787232196	1391	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C	Unknown	Unknown	Unknown
YPR006C	YPR006C	ICL2	hom	Verified	0.235247642223788	0.407008265111069	no	2013	0.410537976387305	1356	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol	threonine catabolic process|propionate metabolic process	methylisocitrate lyase activity	mitochondrion|mitochondrial matrix
YMR302C	YMR302C	YME2	hom	Verified	0.235084197059627	0.407071691975923	no	2014	0.377833266206915	1237	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases	mitochondrial genome maintenance	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YCL022C_d	YCL022C	YCL022C	hom	Dubious	0.234152121734131	0.407433441563342	no	2015	0.373787140107359	1226	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W	Unknown	Unknown	Unknown
YDL119C_p	YDL119C	YDL119C	hom	Uncharacterized	0.234020005525355	0.40748472384103	no	2016	0.407197141267683	1353	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria	transport	transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YPR092W_d	YPR092W	YPR092W	hom	Dubious	0.233737095345079	0.407594543695705	no	2017	0.410245944048274	1357	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR147W	YDR147W	EKI1	hom	Verified	0.233039958800536	0.407865188598578	no	2018	0.422158462493242	1412	NA	FT	LIPID METABOLISM			Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolamine kinase activity|choline kinase activity	cytoplasm
YIL010W	YIL010W	DOT5	hom	Verified	0.23200456453235	0.408267234269757	no	2019	0.381315158865898	1259	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|CHROMOSOME		Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth	cellular response to oxidative stress|cell redox homeostasis	thioredoxin peroxidase activity	nucleus
YOR384W	YOR384W	FRE5	hom	Verified	0.231779727943306	0.408354551546883	no	2020	0.418683983614544	1371	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION|PLASMA MEMBRANE		Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	ferric-chelate reductase activity	mitochondrion|integral to membrane
YDR406W	YDR406W	PDR15	hom	Verified	0.228945400102752	0.409455676685319	no	2021	0.416027088362732	1373	NA	FT	NUCLEOTIDE METABOLISM			Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element	transport|response to drug	ATPase activity, coupled to transmembrane movement of substances	integral to membrane
YDR479C	YDR479C	PEX29	hom	Verified	0.228861344797287	0.409488342792742	no	2022	0.419428903693108	1401	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress	peroxisome organization	molecular_function	integral to membrane|peroxisomal membrane
YER007C-A	YER007C-A	TMA20	hom	Verified	0.227655060525467	0.409957205771645	no	2023	0.396731785706758	1326	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION			Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress	ribosome biogenesis	RNA binding	ribosome|cytoplasm
YPL017C	YPL017C	IRC15	hom	Verified	0.226723267611323	0.410319466634969	no	2024	0.427393941749329	1398	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci	microtubule nucleation|mitotic recombination|microtubule anchoring|meiotic sister chromatid segregation|attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|positive regulation of mitotic cell cycle	microtubule binding|S-adenosylmethionine-dependent methyltransferase activity	microtubule|cytoplasm
YKL222C	YKL222C	YKL222C	hom	Verified	0.226276819295392	0.41049306319107	no	2025	0.408509641845864	1331	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CYTOSKELETON		Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine	biological_process	sequence-specific DNA binding	ribosome|nucleus|mitotic spindle
YER011W	YER011W	TIR1	hom	Verified	0.225867276618879	0.410652324815835	no	2026	0.385135424981172	1280	NA					Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking	response to stress	structural constituent of cell wall	fungal-type cell wall
YJL029C	YJL029C	VPS53	hom	Verified	0.224264493863022	0.411275751180875	no	2027	0.367540253843264	1235	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting	Golgi to vacuole transport|retrograde transport, endosome to Golgi	molecular_function	Golgi apparatus|GARP complex|cytoplasm
YLR419W_p	YLR419W	YLR419W	hom	Uncharacterized	0.223907512858067	0.411414634863375	no	2028	0.41445703889767	1347	NA	FT		MITOCHONDRION		Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene	biological_process	molecular_function	mitochondrion|cytoplasm
YBR201W	YBR201W	DER1	hom	Verified	0.223830445195027	0.411444619543341	no	2029	0.417495087008572	1381	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p	ER-associated protein catabolic process	molecular_function	integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YIL121W	YIL121W	QDR2	hom	Verified	0.22353393824969	0.411559986184912	no	2030	0.400012209428298	1308	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper	drug transmembrane transport|potassium ion import	drug transmembrane transporter activity	integral to membrane|integral to plasma membrane
YLR151C	YLR151C	PCD1	hom	Verified	0.223392266475856	0.411615111360396	no	2031	0.41320718873593	1350	NA	FT	NUCLEOTIDE METABOLISM			Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member	biological_process	pyrophosphatase activity	peroxisome
YPL145C	YPL145C	KES1	hom	Verified	0.223380680595982	0.411619619559729	no	2032	0.407480684902918	1316	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication	post-Golgi vesicle-mediated transport|positive regulation of phosphatase activity|maintenance of cell polarity|endocytosis|exocytosis|sterol transport	phosphatidic acid binding|lipid binding|phosphatidylinositol-4,5-bisphosphate binding|oxysterol binding|sterol transporter activity|phosphatidylinositol-4-phosphate binding	Golgi membrane|extrinsic to membrane|cytoplasm
YGR168C_p	YGR168C	YGR168C	hom	Uncharacterized	0.223110295020127	0.411724833014481	no	2033	0.431282803274172	1427	NA					Putative protein of unknown function; YGR168C is not an essential gene	biological_process	molecular_function	integral to membrane
YNR018W	YNR018W	RCF2	hom	Verified	0.222268982530757	0.412052248270363	no	2034	0.41226905611933	1339	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion|mitochondrial respiratory chain supercomplex|mitochondrial respiratory chain complex IV|integral to mitochondrial inner membrane
YIR044C	YIR044C	YIR044C	hom	pseudogene	0.222151435935897	0.412097998992897	no	2035	0.409771903738995	1373	NA					Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family	biological_process	molecular_function	cellular_component
YDR249C_p	YDR249C	YDR249C	hom	Uncharacterized	0.221077102610509	0.41251619931811	no	2036	0.426216836303627	1394	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR307C	YOR307C	SLY41	hom	Verified	0.220996384069416	0.412547624236195	no	2037	0.426553499106655	1405	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM		Protein involved in ER-to-Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum
YLR187W	YLR187W	SKG3	hom	Verified	0.220866195641423	0.412598309691703	no	2038	0.41430184650331	1362	NA	FT		SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication	biological_process	molecular_function	cellular bud|cellular bud neck|cytoplasm
YIL085C	YIL085C	KTR7	hom	Verified	0.219554630567809	0.413109014373668	no	2039	0.403245797347324	1300	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication	fungal-type cell wall organization|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YDR457W	YDR457W	TOM1	hom	Verified	0.218067554155212	0.413688238540221	no	2040	0.389191668877051	1299	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|PROTEOLYSIS|RNA LOCALIZATION	NUCLEUS		E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mitosis|nucleocytoplasmic transport|nucleus organization|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell size|protein ubiquitination	ubiquitin-protein ligase activity	integral to membrane|nucleolus|nucleus
YML067C	YML067C	ERV41	hom	Verified	0.217775222168512	0.413802125536366	no	2041	0.415951449927217	1350	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein	ER to Golgi vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YLR390W-A	YLR390W-A	CCW14	hom	Verified	0.217179103067813	0.414034384686582	no	2042	0.412506340286839	1336	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall	fungal-type cell wall organization	structural constituent of cell wall	mitochondrion|fungal-type cell wall
YDL144C	YDL144C	YDL144C	hom	Verified	0.21711706920297	0.414058555969302	no	2043	0.409455406857028	1352	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YKL094W	YKL094W	YJU3	hom	Verified	0.216286009284945	0.414382406976788	no	2044	0.412441805880912	1369	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM|MITOCHONDRION		Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family	triglyceride metabolic process	serine hydrolase activity|acylglycerol lipase activity	mitochondrial outer membrane|lipid particle|plasma membrane|membrane|cytoplasm
YNL293W	YNL293W	MSB3	hom	Verified	0.216043320859823	0.414476989839343	no	2045	0.409221546771158	1346	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress	actin filament organization|exocytosis	Rab GTPase activator activity	incipient cellular bud site|polarisome|cellular bud tip
YDR387C_p	YDR387C	YDR387C	hom	Uncharacterized	0.215860066064805	0.414548412943559	no	2046	0.406066636402963	1331	NA					Putative transporter, member of the sugar porter family; YDR387C is not an essential gene	transport|transmembrane transport	substrate-specific transmembrane transporter activity	integral to membrane|membrane
YEL052W	YEL052W	AFG1	hom	Verified	0.21566435297279	0.414624694758249	no	2047	0.409896541745584	1371	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|RESPONSE TO OXIDATIVE STRESS|PEROXISOME ORGANIZATION	MITOCHONDRION		Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain	protein import into peroxisome matrix|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process	molecular_function	mitochondrion|mitochondrial inner membrane
YLR341W	YLR341W	SPO77	hom	Verified	0.215663446689996	0.414625048001671	no	2048	0.418125429753074	1368	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis	ascospore wall assembly|ascospore formation	molecular_function	intracellular
YMR269W	YMR269W	TMA23	hom	Verified	0.215388997157826	0.414732023848458	no	2049	0.414884307290568	1368	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan	ribosomal small subunit biogenesis	molecular_function	ribosome|nucleolus
YDR482C	YDR482C	CWC21	hom	Verified	0.213899287556872	0.415312797911908	no	2050	0.423550811773496	1389	NA	FT	RNA PROCESSING	NUCLEUS		Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YLR299W	YLR299W	ECM38	hom	Verified	0.213087432489599	0.415629383482053	no	2051	0.391317709426381	1271	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation	xenobiotic metabolic process|glutathione catabolic process	gamma-glutamyltransferase activity	fungal-type vacuole
YEL011W	YEL011W	GLC3	hom	Verified	0.212824252155498	0.415732023289761	no	2052	0.392519479589807	1301	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	glycogen biosynthetic process	1,4-alpha-glucan branching enzyme activity	cytoplasm
YMR087W	YMR087W	YMR087W	hom	Verified	0.212537631651068	0.415843811257132	no	2053	0.417094192934305	1396	NA	FT	RNA PROCESSING			Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain	tRNA splicing, via endonucleolytic cleavage and ligation	phosphatase activity	cellular_component
YLR247C	YLR247C	IRC20	hom	Verified	0.210870578845948	0.416494131290721	no	2054	0.401346475271388	1338	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci	double-strand break repair via synthesis-dependent strand annealing	helicase activity	mitochondrion|nucleus
YGL067W	YGL067W	NPY1	hom	Verified	0.210025309260722	0.416823959810382	no	2055	0.390263772397852	1275	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member	NADH metabolic process	NAD+ diphosphatase activity	peroxisome|cytoplasm
YIL001W_p	YIL001W	YIL001W	hom	Uncharacterized	0.20825539238706	0.417514779852831	no	2056	0.42358286130083	1399	NA					Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm	biological_process	molecular_function	cytoplasm
YLR262C	YLR262C	YPT6	hom	Verified	0.207521481273952	0.417801309085933	no	2057	0.456729950403944	1509	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	GOLGI APPARATUS|PLASMA MEMBRANE		Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6	intracellular protein transport|retrograde transport, endosome to Golgi	GTPase activity	Golgi apparatus
YFR035C_p	YFR035C	YFR035C	hom	Uncharacterized	0.207492939197006	0.417812453197281	no	2058	0.402818944401397	1292	NA					Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein	biological_process	molecular_function	cellular_component
YGL006W	YGL006W	PMC1	hom	Verified	0.207320417080836	0.417879815000434	no	2059	0.414396161900645	1367	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a	cellular calcium ion homeostasis|calcium ion transport|transmembrane transport	calcium-transporting ATPase activity	fungal-type vacuole membrane|integral to membrane
YNL314W	YNL314W	DAL82	hom	Verified	0.206306226888875	0.418275857403232	no	2060	0.425755487356688	1387	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain	allantoin catabolic process|nitrogen catabolite activation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YLR385C	YLR385C	SWC7	hom	Verified	0.205571146330292	0.418562959006262	no	2061	0.410306935531928	1361	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin	chromatin remodeling	molecular_function	Swr1 complex|nucleus
YFL052W_p	YFL052W	YFL052W	hom	Uncharacterized	0.203903712939954	0.419214371765087	no	2062	0.397875460624753	1326	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity	biological_process	DNA binding	cellular_component
YDR414C	YDR414C	ERD1	hom	Verified	0.20264571594399	0.419705977551467	no	2063	0.432487162387654	1431	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)	protein retention in ER lumen|protein glycosylation	molecular_function	integral to membrane|membrane
YLR416C_d	YLR416C	YLR416C	hom	Dubious	0.202210684251324	0.419876010418911	no	2064	0.413466148695	1341	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER167W	YER167W	BCK2	hom	Verified	0.202167357389801	0.419892945615046	no	2065	0.447042319323465	1481	NA	FT	CELL CYCLE	NUCLEUS		Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations	regulation of cell cycle|positive regulation of gene expression|G1/S transition of mitotic cell cycle	molecular_function	nucleus|cytoplasm
YAL019W	YAL019W	FUN30	hom	Verified	0.20136507137826	0.420206562398464	no	2066	0.418839383119503	1375	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|MITOCHONDRION|CHROMOSOME		Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate	chromosome organization|chromatin silencing at rDNA|heterochromatin maintenance involved in chromatin silencing|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|heterochromatin assembly involved in chromatin silencing	chromatin binding|DNA-dependent ATPase activity|DNA binding|protein homodimerization activity	mitochondrion|mating-type region heterochromatin|nucleus
YJL092W	YJL092W	SRS2	hom	Verified	0.201013604799112	0.42034396805029	no	2067	0.430045564870154	1423	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability	DNA repair|double-strand break repair via nonhomologous end joining|DNA duplex unwinding	DNA helicase activity	nucleus
YPL201C	YPL201C	YIG1	hom	Verified	0.200906924156009	0.420385676706074	no	2068	0.419386490777833	1397	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol	glycerol biosynthetic process	molecular_function	cytosol|nucleus
YNL193W_p	YNL193W	YNL193W	hom	Uncharacterized	0.200659354201878	0.420482471935945	no	2069	0.396627326354573	1319	NA					Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis	biological_process	molecular_function	cellular_component
YOR144C	YOR144C	ELG1	hom	Verified	0.198828260170472	0.421198544448954	no	2070	0.416497208908654	1368	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication	negative regulation of DNA recombination|negative regulation of transposition, RNA-mediated|telomere maintenance|double-strand break repair via homologous recombination|DNA-dependent DNA replication|mitotic sister chromatid cohesion	chromatin binding	Elg1 RFC-like complex|mitochondrion|nucleus|cytoplasm
YJR015W_p	YJR015W	YJR015W	hom	Uncharacterized	0.198759215620108	0.421225550310728	no	2071	0.41218539138897	1337	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum|cytoplasm
YDR532C	YDR532C	KRE28	hom	Verified	0.197980348345158	0.421530219575337	no	2072	0.436742084059445	1421	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components	biological_process	molecular_function	chromosome, centromeric region|condensed nuclear chromosome kinetochore|spindle pole body
YBR022W	YBR022W	POA1	hom	Verified	0.197815190848779	0.421594830224456	no	2073	0.416813794566681	1382	NA	FT	RNA PROCESSING			Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing	tRNA splicing, via endonucleolytic cleavage and ligation	phosphatase activity	cellular_component
YOR343C_d	YOR343C	YOR343C	hom	Dubious	0.196916730007666	0.421946350677013	no	2074	0.417226418777126	1373	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR133W	YJR133W	XPT1	hom	Verified	0.196915259303505	0.42194692613723	no	2075	0.433373483478241	1409	NA	FT	NUCLEOTIDE METABOLISM			Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine	XMP salvage|hypoxanthine metabolic process	xanthine phosphoribosyltransferase activity|hypoxanthine phosphoribosyltransferase activity	cytoplasm
YBL093C	YBL093C	ROX3	hom	Verified	0.196819119117906	0.421984544432723	no	2076	0.432544582618967	1418	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme	negative regulation of transcription from RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription factor recruiting transcription factor activity	core mediator complex|nucleus
YJL175W_d	YJL175W	YJL175W	hom	Dubious	0.19679734690362	0.421993063691246	no	2077	0.420627854929286	1387	NA					Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor	Unknown	Unknown	Unknown
YLR400W_d	YLR400W	YLR400W	hom	Dubious	0.196124997787277	0.422256165398378	no	2078	0.425784078520755	1393	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL087W	YNL087W	TCB2	hom	Verified	0.195670589994277	0.422434002594466	no	2079	0.419524352809003	1386	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud	biological_process	lipid binding	cellular bud|cortical endoplasmic reticulum
YBR125C	YBR125C	PTC4	hom	Verified	0.194839872919083	0.422759153178416	no	2080	0.409110697996509	1333	NA					Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity	protein dephosphorylation	protein serine/threonine phosphatase activity	cytoplasm
YDR385W	YDR385W	EFT2	hom	Verified	0.191055427800627	0.424241083886897	no	2081	0.421649027718996	1395	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication	translational elongation|positive regulation of translational elongation	translation elongation factor activity	ribosome
YHL036W	YHL036W	MUP3	hom	Verified	0.189933779196472	0.424680511134649	no	2082	0.43588967078317	1437	NA					Low affinity methionine permease, similar to Mup1p	amino acid transport	L-methionine transmembrane transporter activity	integral to membrane|membrane
YJL036W	YJL036W	SNX4	hom	Verified	0.189539818421451	0.424834875031676	no	2083	0.44703163430893	1461	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p	piecemeal microautophagy of nucleus|mitochondrion degradation|early endosome to Golgi transport|CVT pathway|protein targeting to vacuole	phosphatidylinositol-3-phosphate binding	cytosol|pre-autophagosomal structure|extrinsic to membrane|early endosome
YPR002W	YPR002W	PDH1	hom	Verified	0.188666192536239	0.42517722506327	no	2084	0.415570770302915	1376	NA	FT	KETONE METABOLISM	MITOCHONDRION		Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate	propionate metabolic process|propionate catabolic process, 2-methylcitrate cycle	2-methylcitrate dehydratase activity	mitochondrial outer membrane|mitochondrion|cytoplasm
YMR158W-B_d	YMR158W-B	YMR158W-B	hom	Dubious	0.187680655691898	0.425563497656896	no	2085	0.409119378159157	1355	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C	Unknown	Unknown	Unknown
YNL109W_d	YNL109W	YNL109W	hom	Dubious	0.187411937025584	0.425668832013497	no	2086	0.431948644103464	1404	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C	Unknown	Unknown	Unknown
YFR046C	YFR046C	CNN1	hom	Verified	0.186615293014815	0.425981137650055	no	2087	0.420063819819155	1365	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T	chromosome segregation	molecular_function	nucleus|kinetochore
YOL103W	YOL103W	ITR2	hom	Verified	0.186614354880525	0.425981505451053	no	2088	0.43025137686301	1439	NA	FT		PLASMA MEMBRANE		Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively	myo-inositol transport	myo-inositol transmembrane transporter activity	integral to membrane|plasma membrane|membrane
YGR027C	YGR027C	RPS25A	hom	Verified	0.186594445357797	0.425989311110276	no	2089	0.435440320619696	1452	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YFL054C_p	YFL054C	YFL054C	hom	Uncharacterized	0.185901585716649	0.426260969328762	no	2090	0.420986927347163	1395	NA					Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol	water transport|transmembrane transport	water channel activity|glycerol transmembrane transporter activity|transporter activity	integral to membrane
YJL075C_d	YJL075C	APQ13	hom	Dubious	0.185833551364193	0.426287646304217	no	2091	0.429873985831971	1422	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate	Unknown	Unknown	Unknown
YML057C-A_d	YML057C-A	YML057C-A	hom	Dubious	0.185826839207511	0.426290278228772	no	2092	0.407289606570416	1327	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W	Unknown	Unknown	Unknown
YGR068C	YGR068C	ART5	hom	Verified	0.185694282965047	0.426342255940176	no	2093	0.431257083757648	1414	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane	ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	cellular_component
YNL085W	YNL085W	MKT1	hom	Verified	0.184323241273901	0.426879941193797	no	2094	0.427345866442122	1392	NA	FT	RESPONSE TO DNA DAMAGE|TRANSLATION			Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress	positive regulation of translation|interspecies interaction between organisms|response to DNA damage stimulus	nuclease activity	polysome|cytoplasm
YBR053C_p	YBR053C	YBR053C	hom	Uncharacterized	0.184249924064714	0.426908698045331	no	2095	0.41755996456305	1362	NA					Putative protein of unknown function; induced by cell wall perturbation	biological_process	molecular_function	cellular_component
YHR014W	YHR014W	SPO13	hom	Verified	0.183775623326681	0.42709474009027	no	2096	0.412729583988064	1342	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II	protein localization to chromosome, centromeric region|meiotic sister chromatid cohesion|positive regulation of sister chromatid cohesion	molecular_function	nucleus|condensed nuclear chromosome, centromeric region
YNL133C	YNL133C	FYV6	hom	Verified	0.182795194762912	0.427479359555519	no	2097	0.441797086786643	1453	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining	double-strand break repair via nonhomologous end joining	molecular_function	nucleus
YFR043C	YFR043C	IRC6	hom	Verified	0.182648637929643	0.427536859334857	no	2098	0.425835167471176	1414	NA					Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YKR094C	YKR094C	RPL40B	hom	Verified	0.182624246992925	0.427546428969707	no	2099	0.415305289033408	1360	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION	NUCLEUS|MITOCHONDRION	RIBOSOME	Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication	cytoplasmic translation|protein ubiquitination|ribosome biogenesis	structural constituent of ribosome|protein tag	mitochondrion|cytosolic large ribosomal subunit
YFL004W	YFL004W	VTC2	hom	Verified	0.181728147936231	0.427898037459679	no	2100	0.425749374163667	1425	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion	polyphosphate metabolic process|vacuolar transport|microautophagy|protein localization|vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex
YER185W	YER185W	PUG1	hom	Verified	0.181486240333812	0.427992966220388	no	2101	0.40966267620842	1359	NA	FT		PLASMA MEMBRANE		Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins	heme transport	molecular_function	integral to membrane|plasma membrane
YDL173W	YDL173W	PAR32	hom	Verified	0.181384247810168	0.428032991114185	no	2102	0.43854262949022	1459	NA					Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene	biological_process	molecular_function	cytoplasm
YOL003C	YOL003C	PFA4	hom	Verified	0.180064372677711	0.428551015942855	no	2103	0.428815406161149	1432	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases	protein palmitoylation	palmitoyltransferase activity	integral to membrane|endoplasmic reticulum
YBR191W	YBR191W	RPL21A	hom	Verified	0.179895198467933	0.42861742238786	no	2104	0.427989360505951	1394	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YMR009W	YMR009W	ADI1	hom	Verified	0.179694685789354	0.428696132830367	no	2105	0.417981502487254	1374	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions	L-methionine salvage from methylthioadenosine	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	nucleus|cytoplasm
YML062C	YML062C	MFT1	hom	Verified	0.17888139227469	0.429015416965054	no	2106	0.432047127626096	1426	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION	NUCLEUS		Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance	mRNA export from nucleus|DNA recombination|transcription elongation from RNA polymerase II promoter	protein complex scaffold|nucleic acid binding	THO complex part of transcription export complex|nucleoplasmic THO complex
YLR266C	YLR266C	PDR8	hom	Verified	0.177595786572654	0.429520216884909	no	2107	0.416371300093749	1379	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YGL083W	YGL083W	SCY1	hom	Verified	0.176812712449258	0.429827751646423	no	2108	0.431932674701384	1418	NA	FT	PROTEIN PHOSPHORYLATION			Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase	biological_process	molecular_function	clathrin-coated vesicle
YER095W	YER095W	RAD51	hom	Verified	0.176661925987097	0.42988697453532	no	2109	0.442853988378379	1453	NA	FF|FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein	strand invasion|telomere maintenance via recombination|heteroduplex formation|meiotic joint molecule formation|reciprocal meiotic recombination|double-strand break repair via single-strand annealing	recombinase activity|single-stranded DNA binding|DNA-dependent ATPase activity	condensed nuclear chromosome|nuclear chromosome
YOR219C	YOR219C	STE13	hom	Verified	0.176220832862657	0.430060227317802	no	2110	0.443419168130194	1466	NA	FT	PROTEOLYSIS	GOLGI APPARATUS		Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor	peptide pheromone maturation	aminopeptidase activity	trans-Golgi network
YHR200W	YHR200W	RPN10	hom	Verified	0.175337356590574	0.4304072800467	no	2111	0.436627033643336	1440	NA	FT	PROTEOLYSIS			Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein	ubiquitin-dependent protein catabolic process	structural molecule activity|polyubiquitin binding	proteasome complex|proteasome regulatory particle, base subcomplex
YNL080C	YNL080C	EOS1	hom	Verified	0.175128348298295	0.430489391878116	no	2112	0.441242718152128	1443	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene	cellular response to oxidative stress|protein N-linked glycosylation	molecular_function	integral to membrane|endoplasmic reticulum membrane
YGL258W	YGL258W	VEL1	hom	Verified	0.174770454105653	0.430630002596068	no	2113	0.442887010802185	1468	NA					Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C	biological_process	molecular_function	cytosol
YIR023W	YIR023W	DAL81	hom	Verified	0.174538842089893	0.430721003821021	no	2114	0.480479429600985	1576	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism	nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process|urea catabolic process	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YMR055C	YMR055C	BUB2	hom	Verified	0.173990490513948	0.430936467857357	no	2115	0.429495756380109	1421	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM	CYTOSKELETON		Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint	GTPase activator activity	spindle pole body
YGR269W_d	YGR269W	YGR269W	hom	Dubious	0.173696205289355	0.431052109966657	no	2116	0.468603414863301	1549	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C	Unknown	Unknown	Unknown
YBR156C	YBR156C	SLI15	hom	Verified	0.172583734241876	0.431489319115107	no	2117	0.434820524344827	1434	NA	FT	CELL DIVISION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON		Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly	chromosome segregation|protein phosphorylation|regulation of cytokinesis	protein kinase activator activity	spindle microtubule|spindle midzone|chromosome passenger complex|kinetochore microtubule
YJR082C	YJR082C	EAF6	hom	Verified	0.170598737631338	0.432269645299128	no	2118	0.429108237997869	1432	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3	DNA repair|histone acetylation	histone acetyltransferase activity	nucleus|NuA4 histone acetyltransferase complex|NuA3 histone acetyltransferase complex
YDR379W	YDR379W	RGA2	hom	Verified	0.170400750507639	0.432347490977196	no	2119	0.427543360011418	1407	NA	FT	SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p	budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|actin filament organization|pseudohyphal growth|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth	Rho GTPase activator activity	cellular bud neck split septin rings
YDL124W	YDL124W	YDL124W	hom	Verified	0.170385914810376	0.432353324264939	no	2120	0.421649427112578	1411	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress|cellular ketone metabolic process|cellular amide metabolic process|cellular aromatic compound metabolic process	alpha-keto amide reductase activity|aldo-keto reductase (NADP) activity|alditol:NADP+ 1-oxidoreductase activity|alpha-keto ester reductase activity	nucleus|plasma membrane|cytoplasm
YKL055C	YKL055C	OAR1	hom	Verified	0.169108863799276	0.432855506521155	no	2121	0.440862539273271	1451	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p	fatty acid metabolic process|aerobic respiration	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	mitochondrion
YNR056C	YNR056C	BIO5	hom	Verified	0.169103759505894	0.432857513930525	no	2122	0.422128843656147	1386	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	PLASMA MEMBRANE		Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis	biotin biosynthetic process|vitamin transport	transmembrane transporter activity	integral to membrane|plasma membrane
YLR094C	YLR094C	GIS3	hom	Verified	0.168148088773039	0.433233389257308	no	2123	0.438317504625937	1444	NA	FT	SIGNALING	NUCLEUS		Protein of unknown function	intracellular signal transduction	molecular_function	nucleus|cytoplasm
YDR490C	YDR490C	PKH1	hom	Verified	0.167870425523902	0.433342608466241	no	2124	0.427725202452331	1410	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION			Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p	regulation of nuclear-transcribed mRNA poly(A) tail shortening|endocytosis|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly	protein kinase activity	cytosol|cell cortex|eisosome
YDL001W	YDL001W	RMD1	hom	Verified	0.16717360146759	0.43361672753885	no	2125	0.430154285040375	1423	NA	FT	CELL CYCLE			Cytoplasmic protein required for sporulation	biological_process	molecular_function	cytoplasm
YDR035W	YDR035W	ARO3	hom	Verified	0.166210258300144	0.433995743390926	no	2126	0.465521654263301	1547	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan	aromatic amino acid family biosynthetic process	3-deoxy-7-phosphoheptulonate synthase activity	mitochondrion|nucleus|cytoplasm
YGR223C	YGR223C	HSV2	hom	Verified	0.166047496303719	0.434059786155258	no	2127	0.435300354725377	1407	NA	FT	MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS			Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization	piecemeal microautophagy of nucleus	phosphatidylinositol binding	endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YIL159W	YIL159W	BNR1	hom	Verified	0.165688461330058	0.434201063532409	no	2128	0.430806572226869	1425	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1	barbed-end actin filament capping|actin filament bundle assembly|formin-nucleated actin cable assembly	profilin binding	cellular bud neck
YKR078W	YKR078W	YKR078W	hom	Verified	0.165067151306041	0.434445563880505	no	2129	0.441570451751857	1437	NA					Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)	biological_process	phosphatidylinositol-3-phosphate binding	cytoplasm
YBR159W	YBR159W	IFA38	hom	Verified	0.165032394061342	0.434459242428746	no	2130	0.437966203210075	1464	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides	fatty acid elongation	ketoreductase activity	integral to membrane|endoplasmic reticulum
YOL162W_p	YOL162W	YOL162W	hom	Uncharacterized	0.163873691399885	0.434915289154795	no	2131	0.432984950168975	1429	NA					Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family	transmembrane transport	transmembrane transporter activity	integral to membrane|membrane
YOL164W-A_p	YOL164W-A	YOL164W-A	hom	Uncharacterized	0.162616254172473	0.435410294184862	no	2132	0.4311027860814	1407	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YHR160C	YHR160C	PEX18	hom	Verified	0.16224399229469	0.435556858928634	no	2133	0.445198759341139	1462	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p	protein import into peroxisome matrix	protein binding	cytosol|peroxisome
YOR328W	YOR328W	PDR10	hom	Verified	0.161538103772234	0.435834801472526	no	2134	0.433372461433523	1400	NA	FT	NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p	drug transmembrane transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|plasma membrane
YMR202W	YMR202W	ERG2	hom	Verified	0.161103194249408	0.436006062231136	no	2135	0.493423339756463	1647	NA	FF|FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis	ergosterol biosynthetic process	C-8 sterol isomerase activity	endoplasmic reticulum
YKL008C	YKL008C	LAC1	hom	Verified	0.160650283660781	0.436184424290501	no	2136	0.435078330174797	1441	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p	replicative cell aging|ceramide biosynthetic process	sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YHR137W	YHR137W	ARO9	hom	Verified	0.160603478115174	0.43620285766146	no	2137	0.435757392667812	1449	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism	aromatic amino acid family metabolic process	aromatic-amino-acid:2-oxoglutarate aminotransferase activity	nucleus|cytoplasm
YPR078C_p	YPR078C	YPR078C	hom	Uncharacterized	0.15888220116394	0.436880841985611	no	2138	0.438971956203569	1436	NA					Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible	biological_process	molecular_function	cellular_component
YJR100C	YJR100C	AIM25	hom	Verified	0.158736382386564	0.436938286290641	no	2139	0.425827848428705	1403	NA	FT		MITOCHONDRION		Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YEL053C	YEL053C	MAK10	hom	Verified	0.158233361854689	0.437136457968968	no	2140	0.43881078792887	1447	NA					Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex|cytoplasm
YGR238C	YGR238C	KEL2	hom	Verified	0.157837735321533	0.437292331426951	no	2141	0.424117314368711	1392	NA	FT	CELL CYCLE	SITE OF POLARIZED GROWTH		Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate	conjugation with cellular fusion|negative regulation of exit from mitosis	molecular_function	mating projection tip|cellular bud neck|cellular bud tip
YPL178W	YPL178W	CBC2	hom	Verified	0.157827538018665	0.437296349205526	no	2142	0.389752048733571	1282	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif	mRNA splicing, via spliceosome	RNA cap binding	commitment complex|nuclear cap binding complex
YDR250C_d	YDR250C	YDR250C	hom	Dubious	0.157533822723367	0.437412076993688	no	2143	0.438077697733836	1457	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YCL057C-A	YCL057C-A	MOS1	hom	Verified	0.157064443388282	0.437597029895442	no	2144	0.410669531036045	1371	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein essential for proper inner membrane organization; conserved component of the mitochondrial inner membrane organizing system (MICOS, MINOS, or MitOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture; ortholog of human MINOS1	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YNL322C	YNL322C	KRE1	hom	Verified	0.156812998018092	0.437696114327249	no	2145	0.458750488929468	1517	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall|integral to membrane
YML129C	YML129C	COX14	hom	Verified	0.156225245045528	0.437927739187205	no	2146	0.429479114250793	1405	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes	mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation	molecular_function	mitochondrial envelope|mitochondrion|integral to membrane|mitochondrial inner membrane|mitochondrial matrix|extrinsic to membrane
YHL045W_d	YHL045W	YHL045W	hom	Dubious	0.156115926801372	0.43797082225838	no	2147	0.435601396936514	1433	NA					Putative protein of unknown function; not an essential gene	Unknown	Unknown	Unknown
YKL051W	YKL051W	SFK1	hom	Verified	0.156025331419694	0.438006527077988	no	2148	0.425376724636466	1394	NA	FT	LIPID METABOLISM|SIGNALING|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane	vacuole organization|inositol lipid-mediated signaling|actin cytoskeleton organization	molecular_function	integral to membrane|plasma membrane
YDR019C	YDR019C	GCV1	hom	Verified	0.155833621668151	0.438082084051068	no	2149	0.447784207084741	1488	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm	glycine catabolic process|glycine metabolic process|one-carbon metabolic process	glycine dehydrogenase (decarboxylating) activity	mitochondrion|glycine cleavage complex
YOR025W	YOR025W	HST3	hom	Verified	0.154874610165197	0.438460085129376	no	2150	0.430209555162174	1415	NA	FT	KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism	short-chain fatty acid metabolic process|histone deacetylation|chromatin silencing at telomere	histone deacetylase activity|DNA binding	nucleus
YOR068C	YOR068C	VAM10	hom	Verified	0.154257171405771	0.438703482659366	no	2151	0.439817844812195	1456	NA	FT	MEMBRANE ORGANIZATION			Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering	vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane
YNL329C	YNL329C	PEX6	hom	Verified	0.152912097059581	0.439233798014741	no	2152	0.439751584277229	1450	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol	protein import into peroxisome matrix, receptor recycling|replicative cell aging	ATPase activity|protein heterodimerization activity	cytosol|peroxisome
YDR073W	YDR073W	SNF11	hom	Verified	0.152885834230524	0.439244153610385	no	2153	0.427260062751019	1398	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex
YKL038W	YKL038W	RGT1	hom	Verified	0.151960087596199	0.439609207737691	no	2154	0.44384410103993	1459	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication	glucose transport|regulation of glucose import|negative regulation of transcription from RNA polymerase II promoter|glucose metabolic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nucleus
YLR308W	YLR308W	CDA2	hom	Verified	0.150398185703648	0.44022523629477	no	2155	0.439843717351556	1469	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOL